result 781 件
| Author | Hasei, Joe| Sasaki, Tsuyoshi| Tazawa, Hiroshi| Osaki, Shuhei| Yamakawa, Yasuaki| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Onishi, Teppei| Uno, Futoshi| Kagawa, Shunsuke| Urata, Yasuo| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-03 |
| Publication Title | Molecular Cancer Therapeutics |
| Volume | volume12 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/51068 |
|---|---|
| FullText URL | 67_4_239.pdf |
| Author | Nakamura, Shinichiro| Nouso, Kazuhiro| Kobayashi, Yoshiyuki| Shiraha, Hidenori| Ohnishi, Hideki| Toshimori, Junichi| Kuwaki, Kenji| Hagihara, Hiroaki| Takayama, Hiroki| Yamamoto, Kazuhide| |
| Abstract | The aim of this study was to evaluate the histologic diagnosis of hypovascular hepatic lesions showing hypointensity on hepatobiliary phase images of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI (EOB-MRI). In 38 patients with hepatocellular carcinoma (HCC) after curative treatments and 18 patients with liver cirrhosis, 105 hypovascular nodules that were hypointense at the hepatobiliary phase of EOB-MRI were biopsied and the clinical usefulness of these EOB-MRI findings for the diagnosis of HCC was examined. Of the 105 nodules (median diameter＝12mm), 78 (74.3%), 11 (10.5%), and 16 (15.2%) were diagnosed as HCC, dysplastic, and non-neoplastic, respectively. The positive predictive value (PPV) of hypointensity at the hepatobiliary phase of EOB-MRI for the diagnosis of HCC increased to 77-90% when combined with the following factors: washout appearance on the delayed phase of triple-phase CT, hyperintensity in diffusion-weighted image of MRI, or the appearance of a hypoechoic part in ultrasonography. PPV increased to 100% when all 3 factors were positive. A relatively large proportion of hypovascular lesions that showed hypo-intensity in the hepatobiliary phase were confirmed to be HCC, and the accuracy of HCC increased when combined with other imaging findings. |
| Keywords | hepatocellular carcinoma hypovascular diagnosis gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-08 |
| Volume | volume67 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 239 |
| End Page | 244 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23970322 |
| Web of Science KeyUT | 000323470100005 |
| Author | Tanaka, Toshiyuki| |
|---|---|
| Published Date | 2013-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | jinno, Yasutaka| |
|---|---|
| Published Date | 2013-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Ogawa, Daisuke| |
|---|---|
| Published Date | 2013-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Watanabe, Yoshihisa| |
|---|---|
| Published Date | 2013-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| FullText URL | K0004710.pdf K0004710_honbun.pdf |
|---|---|
| Author | Ika, Katsuhiko| |
| Published Date | 2013-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4710号 |
| Granted Date | 2013-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| Author | Onishi, Manabu| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Fujii, Kentaro| Yoshida, Koichi| Inoue, Satoshi| Michiue, Hiroyuki| Chiocca, E. Antonio| Kaur, Balveen| Date, Isao| |
|---|---|
| Published Date | 2013-04 |
| Publication Title | Neuropathology |
| Volume | volume33 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Shimzu, K.| Takahashi, T.| Iwasaki, T.| Shimizu, H.| Inoue, K.| Morimatsu, H.| Omori, E.| Matsumi, M.| Akagi, R.| Morita, K.| |
|---|---|
| Published Date | 2008-11 |
| Publication Title | Medicinal Chemistry |
| Volume | volume4 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Chowdhury, Goutam| P. Pazhani, Gururaja| Dutta, Devarati| Guin, Sucharita| Dutta, Sanjucta| Ghosh, Santanu| Izumiya, Hidemasa| Asakura, Masahiro| Yamasaki, Shinji| Takeda, Yoshifumi| Arakawa, Eiji| Watanabe, Haruo| Mukhopadhyay, Asish K.| Bhattacharya, Mihir K.| Rajendran, K.| Nair, Gopinath Balakrish| Ramamurthy, Thandavarayan| |
|---|---|
| Published Date | 2012-11 |
| Publication Title | Emerging Infectious Diseases |
| Volume | volume18 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | 西門 義一| 大島 俊市| 野田 二郎| |
|---|---|
| Published Date | 1953-03-31 |
| Publication Title | 農学研究 |
| Volume | volume41 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| Author | Takamiya, M.| Miyamoto, Y.| Yamashita, T.| Deguchi, K.| Ohta, Y.| Abe, K.| |
|---|---|
| Published Date | 2012-09-27 |
| Publication Title | Neuroscience |
| Volume | volume221 |
| Content Type | Journal Article |
| FullText URL | O0004388.pdf O0004388_honbun.pdf |
|---|---|
| Author | Hanayama, Yoshihisa| |
| Published Date | 2012-12-31 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4388号 |
| Granted Date | 2012-12-31 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| JaLCDOI | 10.18926/AMO/49672 |
|---|---|
| FullText URL | 67_2_123.pdf |
| Author | Tanabe, Shunsuke| Shirakawa, Yasuhiro| Takehara, Yuko| Maeda, Naoaki| Katsube, Ryoichi| Ohara, Toshiaki| Sakurama, Kazufumi| Noma, Kazuhiro| Fujiwara, Toshiyoshi| |
| Abstract | An 80-year-old woman, who had been administered α-glucosidase inhibitor for diabetes, was brought to the hospital with the sensation of abdominal fullness and pain. Abdominal computed tomography indicated pneumatosis cystoides intestinalis (PCI) in the small intestinal wall, with free air within the abdomen. A blood examination showed no increases in white blood cells or C-reactive protein level. The patientʼs condition improved with conservative therapy. PCI with pneumoperitoneum induced by α-glucosidase inhibitor is rare, with only 27 cases (excluding the present case) reported in Japan to date. In PCI with pneumoperitoneum, differentiation from gastrointestinal perforation is important and following the clinical symptoms over time is vital. |
| Keywords | pneumatosis cystoides intestinalis pneumoperitoneum α-glucosidase inhibitor |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-04 |
| Volume | volume67 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 123 |
| End Page | 128 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23603930 |
| Web of Science KeyUT | 000317801700008 |
| Author | 岡山大学大学院教育学研究科| |
|---|---|
| Published Date | 2013-02-25 |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Volume | volume152 |
| Content Type | Others |
| JaLCDOI | 10.18926/bgeou/49308 |
|---|---|
| Title Alternative | Acoustic features and evaluation of singing production by nursery school teachers (I) |
| FullText URL | bgeou_152_035_043.pdf |
| Author | Ogawa, Yoko| Shimada, Yumi| |
| Abstract | 本研究は，幼稚園や保育園・所などの保育現場で歌われる保育者の歌声を採取し，印象評 価実験と音響分析により，どのような歌声が保育現場にふさわしいのか検討したものである。 音圧，ピッチ，フォルマントの各音響特徴と照らし合わせたところ，安定した基本周波数や ３～４kHz 付近の明確なスペクトルピーク，緩やかな音圧の推移が「美しい」印象を与え ていること，第３フォルマントと第４フォルマントの接近の有無，高周波数帯域でのエネル ギーの濃淡が，個性的な声質に影響を与えていることが示唆された。さらに大学生が判断す る「良い」声と，子どもたちが「歌ってほしい」声との間にかなりの共通点が認められた。 保育者の歌声に関して偏ったプロトタイプが形成されることのないよう，保育現場でのお手 本のあり方について慎重を期すべきであるとの提案をおこなった。 |
| Keywords | 保育者の歌声 フォルマント スペクトル分析 印象評価実験 SD法 |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Published Date | 2013-02-25 |
| Volume | volume152 |
| Start Page | 35 |
| End Page | 43 |
| ISSN | 1883-2423 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005232364 |
| Author | 岡山大学大学院教育学研究科| |
|---|---|
| Published Date | 2013-02-25 |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Volume | volume152 |
| Content Type | Others |
| JaLCDOI | 10.18926/AMO/49256 |
|---|---|
| FullText URL | 67_1_45.pdf |
| Author | Hashizume, Hiroaki| Sato, Ken| Yamazaki, Yuichi| Horiguchi, Norio| Kakizaki, Satoru| Mori, Masatomo| |
| Abstract | In patients with nonalcoholic steatohepatitis (NASH), the prevalence of cirrhosis is higher among women than men, and hepatocellular carcinoma (HCC) develops mainly in the cirrhotic stage among women. However, the long-term outcomes in female patients with NASH have not been fully elucidated, and age, gender and BMI were not simultaneously adjusted in previous studies on the prognosis of NASH. To elucidate the outcomes in female patients with NASH, we prospectively compared NASH patients with advanced fibrosis (advanced NASH) with hepatitis C virus-related advanced fibrosis (advanced CHC) patients and NASH patients with mild fibrosis (mild NASH) using study cohorts that were adjusted for body mass index (BMI) in addition to age. The median follow-up period was 92.5 months. Liver-related complication-free survival was significantly reduced in the advanced NASH group compared to the mild NASH group. No liver-related complications developed in the mild NASH group. The overall survival, liver-related complication- and cardiovascular/cerebrovascular disease-free survival were not significantly different between the advanced NASH and CHC groups. Female patients with NASH and advanced fibrosis may have a less favorable prognosis for liver-related complications than the matched cohorts with NASH and mild fibrosis, but may have a similar prognosis to the matched cohorts with CHC. |
| Keywords | nonalcoholic steatohepatitis chronic hepatitis C prognosis female |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-02 |
| Volume | volume67 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 45 |
| End Page | 53 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23439508 |
| Web of Science KeyUT | 000316829900006 |
| JaLCDOI | 10.18926/AMO/49254 |
|---|---|
| FullText URL | 67_1_25.pdf |
| Author | Ika, Katsuhiko| Suzuki, Etsuji| Mitsuhashi, Toshiharu| Takao, Soshi| Doi, Hiroyuki| |
| Abstract | The purpose of this study was to examine the association between shift work and diabetes mellitus by separating shift workers according to the intensity of their shift work (seasonal shift work and continuous shift work). Between May and October 2009, we collected data from annual health checkups and questionnaires at a manufacturing company in Shizuoka, Japan. Questionnaires were returned by 1,601 workers (response rate:96.2%, men/women＝1,314/287). Diabetes mellitus was defined as hemoglobin A1c≥6.5% and fasting blood sugar≥126mg/dl. After exclusions, which included all the women and clerical workers because they did not work in shifts, we analyzed 475 skilled male workers. After adjusting for age, smoking status, frequency of alcohol consumption, and cohabitation status, odds ratios for diabetes mellitus were 0.98 (95% confidence interval [CI]:0.28-4.81) and 2.10 (95% CI:0.77-5.71) among seasonal shift workers and continuous shift workers, respectively, compared with non-shift workers. In an age-stratified analysis (＜45 years vs.≥45 years), the association between continuous shift work and diabetes mellitus was more pronounced among older participants. Compared with non-shift workers, the risk of diabetes mellitus was increased among continuous shift workers, whereas its effect is limited among seasonal shift workers. |
| Keywords | cross-sectional study diabetes mellitus intensity Japan shift work |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-02 |
| Volume | volume67 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 25 |
| End Page | 33 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23439506 |
| Web of Science KeyUT | 000316829900004 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/50693 |
| JaLCDOI | 10.18926/AMO/49041 |
|---|---|
| FullText URL | 66_6_449.pdf |
| Author | Hanayama, Yoshihisa| Uchida, Haruhito Adam| Nakamura, Yoshio| Makino, Hirofumi| |
| Abstract | Angiotensin receptor blockers (ARBs) are the first-line antihypertensive agents. In clinical practice, it is often difficult to achieve the recommended blood pressure level by ARBs in their ordinal dosages alone. This study examined the practical efficacy of a combination therapy of ARB with thiazide diuretics for lowering morning home blood pressure (MHBP) in comparison to high-dose ARB therapy in patients with morning hypertension administered an ordinal dosage of ARB. This study was performed in a prospective, randomized, open-labeled and blind-endpoint fashion. Patients were considered to have morning hypertension when their self-measured systolic MHBPs were 135mmHg or higher, irrespective of their diastolic MHBP and office blood pressures (OBPs). Forty-eight outpatients with morning hypertension receiving the ordinal dosage of ARB were given either losartan/hydrochlorothiazide (n＝26) or high-dose ARB (n＝22) in place of their previously prescribed ARB. No change in any medication was permitted during this period. Decreases of both systolic and diastolic MHBP after 3 months of treatment were significantly greater in the losartan/hydrochlorothiazide group than in the high-dose ARB group (p＜0.05, respectively). The ratio of adverse events was somewhat high (23.1% in the losartan/hydrochlorothiazide group, 9.1% in the high-dose ARB group, respectively). However, there were no significant differences in any particular adverse event between groups. This study suggested losartan/hydrochlorothiazide might be superior to high-dose ARB for reducing morning home blood pressure. |
| Keywords | losartan hydrochlorothiazide morning blood pressure angiotensin II hyperuricemia |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-12 |
| Volume | volume66 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 449 |
| End Page | 459 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23254579 |
| Web of Science KeyUT | 000312966100004 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/49736 |
