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JaLCDOI 10.18926/AMO/31097
FullText URL fulltext.pdf
Author Moriwaki, Akiyoshi| Hattori, Yukio| Hayashi, Yasushi| lu, Yun-fei| Islam, Nadira| Hori, Yasuo|
Abstract

A unilateral 30-min application of anodal direct current to the promotor cortex of rabbits was repeated 10 times, and cyclic AMP accumulation in response to histamine was investigated in slices of different cortical areas. Polarization with 1.0 microA decreased the cyclic AMP accumulation in the cortical area contralateral to the polarization, by which regional dominance in cyclic AMP accumulation was produced in the polarized cortex. In contrast, the regional difference in cyclic AMP accumulation was reversed when 10.0 or 30.0 microA was applied. The histamine-elicited accumulation of cyclic AMP was almost completely inhibited by the selective H2-receptor antagonist cimetidine. These results suggest that repeated anodal polarization regionally alters H2-receptor-mediated cyclic AMP generation in the cortex depending on the intensity of the polarizing currents and this pattern of cyclic AMP accumulation is responsible for the characteristic motor behavior induced by anodal polarization.

Keywords anodal polarization cyclic AMP histamine cerebral cortex rabbit
Amo Type Article
Publication Title Acta Medica Okayama
Published Date 1994-12
Volume volume48
Issue issue6
Publisher Okayama University Medical School
Start Page 323
End Page 326
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 7709760
Web of Science KeyUT A1994PZ34600007
JaLCDOI 10.18926/AMO/31018
FullText URL fulltext.pdf
Author Hayashi, Yasushi| Hattori, Yukio| Moriwaki, Akiyoshi| Asaki, Hideki| Hori, Yasuo|
Abstract

The effects of prolonged weak anodal direct current (DC) on the electrocorticogram (ECoG) were investigated in awake rabbits. When the current (20-40 microA) was applied to the motor region of the cerebral cortex, seizure activity in the ECoG appeared from the frontal cortex. Repeated application of the DC decreased the threshold current for producing the seizure activity. Diazepam significantly elevated the threshold of the seizure activity. In contrast to the marked changes in the ECoG, no behavioral changes were observed during or after the application of weak anodal DC. The changes in the ECoG are discussed in relation to the intensity and duration of the DC.

Keywords rabbit cerebral cortex anodal direct current electrocorticogram seizure activity diazepam
Amo Type Article
Publication Title Acta Medica Okayama
Published Date 1988-10
Volume volume42
Issue issue5
Publisher Okayama University Medical School
Start Page 293
End Page 296
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 3223340
Web of Science KeyUT A1988Q771900007
JaLCDOI 10.18926/AMO/30700
FullText URL fulltext.pdf
Author Uezu, Eiko| Hori, Yasuo|
Abstract

Under barbiturate anesthesia, male Wistar rats weighing 250-300 g were injected with 2.5 microliters of 0.2 M FeCl3 solution into the left sensori-motor cortex to induce an epileptic focus with minimal abnormal activities. Polygraphy started 1 week after the surgery, showed a spindle-like hypersynchronous activity that appeared not only in the slow wave sleep period but also during paradoxical sleep (PS). This activity had a frequency of 8-14 Hz. The amplitude was more than 200 mu v in the right (non-injected side) cortex but very small in the left cortex (injected side). Isolated spike discharges were observed in an ECoG of slow wave sleep. Apart from this activity there was nothing resembling the usual sleep spindles.

Keywords iron-induced focus paradoxical sleep spindle-like activity
Amo Type Brief Note
Publication Title Acta Medica Okayama
Published Date 1982-06
Volume volume36
Issue issue3
Publisher Okayama University Medical School
Start Page 237
End Page 240
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 7113750
Web of Science KeyUT A1982NV62100010
Author Michinaka, Tomokatsu|
Published Date 1956-07-31
Publication Title 岡山医学会雑誌
Volume volume68
Issue issue7
Content Type Journal Article
Author Michinaka, Tomokatsu|
Published Date 1956-07-31
Publication Title 岡山医学会雑誌
Volume volume68
Issue issue7
Content Type Journal Article
Author Kosaka, Futami|
Published Date 1956-07-31
Publication Title 岡山医学会雑誌
Volume volume68
Issue issue7
Content Type Journal Article
Author Kosaka, Futami|
Published Date 1956-07-31
Publication Title 岡山医学会雑誌
Volume volume68
Issue issue7
Content Type Journal Article
Author Inoue, Masayuki|
Published Date 1956-06-30
Publication Title 岡山医学会雑誌
Volume volume68
Issue issue6
Content Type Journal Article
Author Tanaka, Toshihiko|
Published Date 1956-04-30
Publication Title 岡山医学会雑誌
Volume volume68
Issue issue1-4
Content Type Journal Article
Author Fujii, Shinichiro|
Published Date 1959-04-05
Publication Title 岡山医学会雑誌
Volume volume71
Issue issue4-2
Content Type Journal Article
Author Onishi, C|
Published Date 1959-03-15
Publication Title 岡山医学会雑誌
Volume volume71
Issue issue3-2
Content Type Journal Article
Author Kusumoto, Tsuyoshi|
Published Date 1959-01-31
Publication Title 岡山医学会雑誌
Volume volume71
Issue issue1
Content Type Journal Article
Author Okumura, Shuzo|
Published Date 1958-03-31
Publication Title 岡山医学会雑誌
Volume volume70
Issue issue3
Content Type Journal Article
Author Miyake, Shintaro|
Published Date 1963-10-30
Publication Title 岡山医学会雑誌
Volume volume75
Issue issue10
Content Type Journal Article
Author Takahara, Jiro|
Published Date 1967-04-30
Publication Title 岡山医学会雑誌
Volume volume79
Issue issue3-4
Content Type Journal Article
Author Sugatani, Hiroshi|
Published Date 1970-03-30
Publication Title 岡山医学会雑誌
Volume volume81
Issue issue9-10
Content Type Journal Article
Author Suemaru, Koso|
Published Date 1979-06-30
Publication Title 岡山医学会雑誌
Volume volume91
Issue issue5-6
Content Type Journal Article