result 58 件
JaLCDOI | 10.18926/AMO/31097 |
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FullText URL | fulltext.pdf |
Author | Moriwaki, Akiyoshi| Hattori, Yukio| Hayashi, Yasushi| lu, Yun-fei| Islam, Nadira| Hori, Yasuo| |
Abstract | A unilateral 30-min application of anodal direct current to the promotor cortex of rabbits was repeated 10 times, and cyclic AMP accumulation in response to histamine was investigated in slices of different cortical areas. Polarization with 1.0 microA decreased the cyclic AMP accumulation in the cortical area contralateral to the polarization, by which regional dominance in cyclic AMP accumulation was produced in the polarized cortex. In contrast, the regional difference in cyclic AMP accumulation was reversed when 10.0 or 30.0 microA was applied. The histamine-elicited accumulation of cyclic AMP was almost completely inhibited by the selective H2-receptor antagonist cimetidine. These results suggest that repeated anodal polarization regionally alters H2-receptor-mediated cyclic AMP generation in the cortex depending on the intensity of the polarizing currents and this pattern of cyclic AMP accumulation is responsible for the characteristic motor behavior induced by anodal polarization. |
Keywords | anodal polarization cyclic AMP histamine cerebral cortex rabbit |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1994-12 |
Volume | volume48 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 323 |
End Page | 326 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 7709760 |
Web of Science KeyUT | A1994PZ34600007 |
JaLCDOI | 10.18926/AMO/31018 |
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FullText URL | fulltext.pdf |
Author | Hayashi, Yasushi| Hattori, Yukio| Moriwaki, Akiyoshi| Asaki, Hideki| Hori, Yasuo| |
Abstract | The effects of prolonged weak anodal direct current (DC) on the electrocorticogram (ECoG) were investigated in awake rabbits. When the current (20-40 microA) was applied to the motor region of the cerebral cortex, seizure activity in the ECoG appeared from the frontal cortex. Repeated application of the DC decreased the threshold current for producing the seizure activity. Diazepam significantly elevated the threshold of the seizure activity. In contrast to the marked changes in the ECoG, no behavioral changes were observed during or after the application of weak anodal DC. The changes in the ECoG are discussed in relation to the intensity and duration of the DC. |
Keywords | rabbit cerebral cortex anodal direct current electrocorticogram seizure activity diazepam |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1988-10 |
Volume | volume42 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 293 |
End Page | 296 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 3223340 |
Web of Science KeyUT | A1988Q771900007 |
JaLCDOI | 10.18926/AMO/30700 |
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FullText URL | fulltext.pdf |
Author | Uezu, Eiko| Hori, Yasuo| |
Abstract | Under barbiturate anesthesia, male Wistar rats weighing 250-300 g were injected with 2.5 microliters of 0.2 M FeCl3 solution into the left sensori-motor cortex to induce an epileptic focus with minimal abnormal activities. Polygraphy started 1 week after the surgery, showed a spindle-like hypersynchronous activity that appeared not only in the slow wave sleep period but also during paradoxical sleep (PS). This activity had a frequency of 8-14 Hz. The amplitude was more than 200 mu v in the right (non-injected side) cortex but very small in the left cortex (injected side). Isolated spike discharges were observed in an ECoG of slow wave sleep. Apart from this activity there was nothing resembling the usual sleep spindles. |
Keywords | iron-induced focus paradoxical sleep spindle-like activity |
Amo Type | Brief Note |
Publication Title | Acta Medica Okayama |
Published Date | 1982-06 |
Volume | volume36 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 237 |
End Page | 240 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 7113750 |
Web of Science KeyUT | A1982NV62100010 |
Author | Michinaka, Tomokatsu| |
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Published Date | 1956-07-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume68 |
Issue | issue7 |
Content Type | Journal Article |
Author | Michinaka, Tomokatsu| |
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Published Date | 1956-07-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume68 |
Issue | issue7 |
Content Type | Journal Article |
Author | Kosaka, Futami| |
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Published Date | 1956-07-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume68 |
Issue | issue7 |
Content Type | Journal Article |
Author | Kosaka, Futami| |
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Published Date | 1956-07-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume68 |
Issue | issue7 |
Content Type | Journal Article |
Author | Inoue, Masayuki| |
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Published Date | 1956-06-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume68 |
Issue | issue6 |
Content Type | Journal Article |
Author | Hatakeyama, Tetsuro| |
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Published Date | 1956-06-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume68 |
Issue | issue6 |
Content Type | Journal Article |
Author | Hatakeyama, Tetsuro| |
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Published Date | 1956-06-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume68 |
Issue | issue6 |
Content Type | Journal Article |
Author | Tanaka, Toshihiko| |
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Published Date | 1956-04-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume68 |
Issue | issue1-4 |
Content Type | Journal Article |
Author | Fujii, Shinichiro| |
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Published Date | 1959-04-05 |
Publication Title | 岡山医学会雑誌 |
Volume | volume71 |
Issue | issue4-2 |
Content Type | Journal Article |
Author | Miyatake, Shozaburo| |
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Published Date | 1959-04-05 |
Publication Title | 岡山医学会雑誌 |
Volume | volume71 |
Issue | issue4-2 |
Content Type | Journal Article |
Author | Onishi, C| |
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Published Date | 1959-03-15 |
Publication Title | 岡山医学会雑誌 |
Volume | volume71 |
Issue | issue3-2 |
Content Type | Journal Article |
Author | Kusumoto, Tsuyoshi| |
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Published Date | 1959-01-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume71 |
Issue | issue1 |
Content Type | Journal Article |
Author | Okumura, Shuzo| |
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Published Date | 1958-03-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume70 |
Issue | issue3 |
Content Type | Journal Article |
Author | Miyake, Shintaro| |
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Published Date | 1963-10-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume75 |
Issue | issue10 |
Content Type | Journal Article |
Author | Takahara, Jiro| |
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Published Date | 1967-04-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume79 |
Issue | issue3-4 |
Content Type | Journal Article |
Author | Sugatani, Hiroshi| |
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Published Date | 1970-03-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume81 |
Issue | issue9-10 |
Content Type | Journal Article |
Author | Suemaru, Koso| |
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Published Date | 1979-06-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume91 |
Issue | issue5-6 |
Content Type | Journal Article |