result 115 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Umemori, Koki| Ono, Kisho| Eguchi, Takanori| Kawai, Hotaka| Nakamura, Tomoya| Ogawa, Tatsuo| Yoshida, Kunihiro| Kanemoto, Hideka| Sato, Kohei| Obata, Kyoichi| Ryumon, Shoji| Yutori, Hirokazu| Katase, Naoki| Okui, Tatsuo| Nagatsuka, Hitoshi| Ibaragi, Soichiro| |
| Keywords | Cetuximab epithelial cell adhesion molecule (EpCAM) EpEX EpICD epidermal growth factor receptor (EGFR) Drug resistance Head and neck squamous cell carcinoma (HNSC) |
| Published Date | 2023-07 |
| Publication Title | Oral Oncology |
| Volume | volume142 |
| Publisher | Elsevier |
| Start Page | 106433 |
| ISSN | 1368-8375 |
| NCID | AA10846349 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Author(s). |
| File Version | publisher |
| PubMed ID | 37236125 |
| DOI | 10.1016/j.oraloncology.2023.106433 |
| Web of Science KeyUT | 001012354300001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.oraloncology.2023.106433 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fiel'ardh, Khalifatulloh| Torkar, Gregor| Rožman, Hana| Fujii, Hiroki| |
| Keywords | sustainable development goals teacher education curricula qualitative content analysis semi-structured interview Japan Slovenia |
| Published Date | 2023-11-09 |
| Publication Title | Frontiers in Education |
| Volume | volume8 |
| Publisher | Frontiers Media |
| Start Page | 1215500 |
| ISSN | 2504-284X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Fiel’ardh, Torkar, Rožman and Fujii. |
| File Version | publisher |
| DOI | 10.3389/feduc.2023.1215500 |
| Web of Science KeyUT | 001115240200001 |
| Related Url | isVersionOf https://doi.org/10.3389/feduc.2023.1215500 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yumoto, Tetsuya| Hongo, Takashi| Koide, Yasuhiro| Obara, Takafumi| Tsukahara, Kohei| Naito, Hiromichi| Nakao, Atsunori| |
| Keywords | Emergency service Informed consent Radiation Treatment refusal |
| Note | The version of record of this article, first published in BMC Medical Ethics, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12910-023-00962-5| |
| Published Date | 2023-10-04 |
| Publication Title | BMC Medical Ethics |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 80 |
| ISSN | 1472-6939 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37794408 |
| DOI | 10.1186/s12910-023-00962-5 |
| Web of Science KeyUT | 001080177500004 |
| Related Url | isVersionOf https://doi.org/10.1186/s12910-023-00962-5 |
| JaLCDOI | 10.18926/AMO/65750 |
|---|---|
| FullText URL | 77_4_395.pdf |
| Author | Pavlovic, Marko| Babic, Dragan| Rastovic, Pejana| Arapovic, Jurica| Martinac, Marko| Jakovac, Sanja| Barbaric, Romana| |
| Abstract | We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia. |
| Keywords | tumor necrosis factor-alpha schizophrenia psychopathology immune system |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 395 |
| End Page | 405 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635140 |
| Web of Science KeyUT | 001163659800010 |
| JaLCDOI | 10.18926/AMO/65749 |
|---|---|
| FullText URL | 77_4_387.pdf |
| Author | Kataoka, Takahiro| Habu, Hiroshi| Tanaka, Ayumi| Naoe, Shota| Murakami, Kaito| Fujimoto, Yuki| Yukimine, Ryohei| Takao, Soshi| Mitsunobu, Fumihiro| Yorifuji, Takashi| Yamaoka, Kiyonori| |
| Abstract | No epidemiological studies have examined the health effects of daily bathing in radon hot springs. In this cross-sectional study, we investigated the associations between radon hot spring bathing and health conditions. The target population was 5,250 adults ≥ 20 years old in the town of Misasa, Japan. We collected information about the participants’ bathing habits and alleviation of a variety of disease symptoms, and their self-rated health (SRH). Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated. In both the adjusted and unadjusted models of hypertension, significant associations between the > 1×/week hot spring bathing and the alleviation of hypertension symptoms were observed compared to the group whose hot spring bathing was <1×/week: adjusted model, OR 5.40 (95%CI: 1.98-14.74); unadjusted model, 3.67 (1.50-8.99) and for gastroenteritis: adjusted model, 9.18 (1.15-72.96); unadjusted model, 7.62 (1.59-36.49). Compared to the no-bathing group, higher SRH was significantly associated with both bathing < 1×/week: unadjusted model, 2.27 (1.53-3.37) and > 1×/week: adjusted model, 1.91 (1.15-3.19). These findings suggest that bathing in radon hot springs is associated with higher SRH and the alleviation of hypertension and gastroenteritis. |
| Keywords | radon hot spring bathing habit self-rated health cross-section study |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 387 |
| End Page | 394 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635139 |
| Web of Science KeyUT | 001163659800003 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyoshi, Toru| Naoe, Satoko| Wakabayashi, Hiroyuki| Yano, Takashi| Mori, Takuya| Kanda, Shingo| Arita, Makoto| Ito, Hiroshi| |
| Keywords | Eicosapentaenoic acid MND-2119 Metablolite Inflammation |
| Published Date | 2023-12-01 |
| Publication Title | Journal of Atherosclerosis and Thrombosis |
| Volume | volume30 |
| Issue | issue12 |
| Publisher | Japan Atherosclerosis Society |
| Start Page | 1927 |
| End Page | 1949 |
| ISSN | 1340-3478 |
| NCID | AA11018976 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | ©2023 Japan Atherosclerosis Society |
| File Version | publisher |
| PubMed ID | 37532570 |
| DOI | 10.5551/jat.64135 |
| Web of Science KeyUT | 001044716000001 |
| Related Url | isVersionOf https://doi.org/10.5551/jat.64135 |
| JaLCDOI | 10.18926/AMO/65741 |
|---|---|
| FullText URL | 77_4_359.pdf |
| Author | Koshida, Tomohiro| Maruta, Toyoaki| Tanaka, Nobuhiko| Hidaka, Kotaro| Kurogi, Mio| Nemoto, Takayuki| Yanagita, Toshihiko| Takeya, Ryu| Tsuneyoshi, Isao| |
| Abstract | Pulsed radiofrequency (PRF) is a safe method of treating neuropathic pain by generating intermittent electric fields at the needle tip. Resiniferatoxin (RTX) is an ultrapotent agonist of transient receptor potential vanilloid subtype-1 (TRPV1) receptors. We investigated the mechanism of PRF using a rat model of RTX-induced neuropathic pain. After administering RTX intraperitoneally, PRF was applied to the right sciatic nerve. We observed the changes in TRPV1, calcitonin gene-related peptide (CGRP), and brain-derived neurotrophic factor (BDNF) in the dorsal root ganglia by western blotting. Expressions of TRPV1 and CGRP were significantly lower in the contralateral (RTX-treated, PRF-untreated) tissue than in control rats (p<0.0001 and p<0.0001, respectively) and the ipsilateral tissues (p<0.0001 and p<0.0001, respectively). BDNF levels were significantly higher in the contralateral tissues than in the control rats (p<0.0001) and the ipsilateral tissues (p<0.0001). These results suggest that, while TRPV1 and CGRP are decreased by RTX-induced neuronal damage, increased BDNF levels result in pain development. PRF may promote recovery from neuronal damage with concomitant restoration of TRPV1 and CGRP, and exert its analgesic effect by reversing BDNF increase. Further research is required to understand the role of TRPV1 and CGRP restoration in improving mechanical allodynia. |
| Keywords | pulsed radiofrequency resiniferatoxin transient receptor potential vanilloid subtype-1 (TRPV1) calcitonin gene-related peptide (CGRP) brain-derived neurotrophic factor (BDNF) |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 359 |
| End Page | 364 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635135 |
| Web of Science KeyUT | 001163659800011 |
| FullText URL | fulltext20230619-03.pdf fig1_20230619-03.pdf fig2_20230619-03.pdf fig3_20230619-03.pdf suppl20230619-03.pdf |
|---|---|
| Author | Akiyama, Mari| Akiyama, Tomoyuki| Saigusa, Daisuke| Hishinuma, Eiji| Matsukawa, Naomi| Shibata, Takashi| Tsuchiya, Hiroki| Mori, Atsushi| Fujii, Yuji| Mogami, Yukiko| Tokorodani, Chiho| Kuwahara, Kozue| Numata-Uematsu, Yurika| Inoue, Kenji| Kobayashi, Katsuhiro| |
| Keywords | Amino acids Biomarkers Intractable epilepsy Ketone bodies Organic acids |
| Note | © 2023 British Epilepsy Association. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.seizure.2023.03.014.| This fulltext file will be available in Apr. 2024.| |
| Published Date | 2023-04 |
| Publication Title | Seizure |
| Volume | volume107 |
| Publisher | Elsevier BV |
| Start Page | 52 |
| End Page | 59 |
| ISSN | 1059-1311 |
| NCID | AA1091615X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 British Epilepsy Association. |
| File Version | author |
| PubMed ID | 36958064 |
| DOI | 10.1016/j.seizure.2023.03.014 |
| Web of Science KeyUT | 000994635600001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.seizure.2023.03.014 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hirabayashi, Daisuke| Yamamoto, Ken-ichi| Maruyama, Akihiro| Tomonobu, Nahoko| Kinoshita, Rie| Chen, Youyi| Komalasari, Ni Luh Gede Yoni| Murata, Hitoshi| Gohara, Yuma| Jiang, Fan| Zhou, Jin| Ruma, I. Made Winarsa| Sumardika, I. Wayan| Yamauchi, Akira| Kuribayashi, Futoshi| Toyooka, Shinichi| Inoue, Yusuke| Sakaguchi, Masakiyo| |
| Keywords | epithelial-to-mesenchymal transition triple-negative breast cancer zinc ZEB1 metastasis |
| Published Date | 2023-02-23 |
| Publication Title | Frontiers in Oncology |
| Volume | volume13 |
| Publisher | Frontiers Media |
| Start Page | 1142886 |
| ISSN | 2234-943X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Hirabayashi, Yamamoto, Maruyama, Tomonobu, Kinoshita, Chen, Komalasari, Murata, Gohara, Jiang, Zhou, Ruma, Sumardika, Yamauchi, Kuribayashi, Toyooka, Inoue and Sakaguchi. |
| File Version | publisher |
| PubMed ID | 36910659 |
| DOI | 10.3389/fonc.2023.1142886 |
| Web of Science KeyUT | 000945660600001 |
| Related Url | isVersionOf https://doi.org/10.3389/fonc.2023.1142886 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Chen, Xiaoting| Arias, Zulema| Omori, Kazuhiro| Yamamoto, Tadashi| Shinoda-Ito, Yuki| Takashiba, Shogo| |
| Keywords | Vitamin D Autophagy Periodontitis Epithelial barrier Immunity Inflammation Alveolar bone loss |
| Published Date | 2023-02-13 |
| Publication Title | BMC Oral Health |
| Volume | volume23 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 90 |
| ISSN | 1472-6831 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 36782172 |
| DOI | 10.1186/s12903-023-02802-9 |
| Web of Science KeyUT | 000937967900001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12903-023-02802-9 |
| JaLCDOI | 10.18926/AMO/64122 |
|---|---|
| FullText URL | 76_6_715.pdf |
| Author | Mohammed Zahedul Islam Nizami| Gorduysus, Melahat| Shinoda-Ito, Yuki| Yamamoto, Tadashi| Nishina, Yuta| Takashiba, Shogo| Arias, Zulema| |
| Abstract | The failure of endodontic treatment is directly associated with microbial infection in the root canal or periapical areas. An endodontic sealer that is both bactericidal and biocompatible is essential for the success of root canal treatments. This is one of the vital issues yet to be solved in clinical dental practice. This in vitro study assessed the effectiveness of graphene oxide (GO) composites GO-CaF2 and GO-Ag-CaF2 as endodontic sealer materials. Dentin slices were coated with either the GO-based composites or commonly used root canal sealers (non-eugenol zinc oxide sealer). The coated slices were treated in 0.9% NaCl, phosphate-buffered saline (PBS), and simulated body fluid (SBF) at 37˚C for 24 hours to compare their sealing effect on the dentin surface. In addition, the radiopacity of these composites was examined to assess whether they complied with the requirements of a sealer for good radiographic visualization. Scanning electron microscopy showed the significant sealing capability of the composites as coating materials. Radiographic images confirmed their radiopacity. Mineral deposition indicated their bioactivity, especially of GO-Ag-CaF2, and thus it is potential for regenerative application. They were both previously shown to be bactericidal to oral microbes and cytocompatible with host cells. With such a unique assemblage of critical properties, these GO-based composites show promise as endodontic sealers for protection against reinfection in root canal treatment and enhanced success in endodontic treatment overall. |
| Keywords | bioactive sealer graphene oxide mineral deposition antimicrobial activity radiopacity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 715 |
| End Page | 721 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549774 |
| Web of Science KeyUT | 000905195100012 |
| JaLCDOI | 10.18926/bgeou/63924 |
|---|---|
| FullText URL | bgeou_180_061_067.pdf |
| Author | Takahashi, Toru| |
| Abstract | This study aims to re-examine the educational significance of learning bodily movement. To realize this goal while considering the related discussions in the previous studies, a potential cue from the concept of affordance developed by Gibson is taken into account. Understanding bodily movement from a perspective related to the concept of affordance generates a notion that learning movement will serve as a proof of using affordances in the environment, which will eventually lead to more options in life in the sense of expanding the possibilities for action. Furthermore, the sense of expanding the possibilities for action is human development, which is something that lasts a lifetime. Simply put, learning movement in itself constitutes a foundation for enriching life and living better, and this further can be recognized as possessing educational significance. |
| Keywords | affordance James J. Gibson possibilities of action |
| Publication Title | Bulletin of Graduate School of Education, Okayama University |
| Published Date | 2022-08-26 |
| Volume | volume180 |
| Start Page | 61 |
| End Page | 67 |
| ISSN | 1883-2423 |
| language | English |
| File Version | publisher |
| JaLCDOI | 10.18926/AMO/63425 |
|---|---|
| FullText URL | 76_2_203.pdf |
| Author | Masuda, Tomoya| Tazawa, Hiroshi| Hashimoto, Yuuri| Ieda, Takeshi| Kikuchi, Satoru| Kuroda, Shinji| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression. |
| Keywords | esophageal cancer EMT TGF-β oncolytic adenovirus E1A |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 203 |
| End Page | 215 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503449 |
| Web of Science KeyUT | 000792291900003 |
| FullText URL | fulltext.pdf Corrigendum.pdf |
|---|---|
| Author | Wang, Chen| Maeda, Masakazu| Chen, Jian| Wang, Mengxue| Naruse, Keiji| Takahashi, Ken| |
| Keywords | TRPM4 Cardiomyocyte H9c2 CRISPR/Cas9 Confocal microscopy DNA sequencing Flow cytometry Western blotting |
| Published Date | 2021 |
| Publication Title | MethodsX |
| Volume | volume8 |
| Publisher | ELSEVIER |
| Start Page | 101404 |
| ISSN | 2215-0161 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Authors. |
| File Version | publisher |
| PubMed ID | 34430300 |
| DOI | 10.1016/j.mex.2021.101404 |
| Web of Science KeyUT | 000707187100026 |
| Related Url | isVersionOf https://doi.org/10.1016/j.mex.2021.101404 |
| JaLCDOI | 10.18926/AMO/62767 |
|---|---|
| FullText URL | 75_5_549.pdf |
| Author | Isooka, Nami| Miyazaki, Ikuko| Asanuma, Masato| |
| Abstract | Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. The loss of nigrostriatal dopaminergic neurons produces its characteristic motor symptoms, but PD patients also have non-motor symptoms such as constipation and orthostatic hypotension. The pathological hallmark of PD is the presence of α-synuclein-containing Lewy bodies and neurites in the brain. However, the PD pathology is observed in not only the central nervous system (CNS) but also in parts of the peripheral nervous system such as the enteric nervous system (ENS). Since constipation is a typical prodromal non-motor symptom in PD, often preceding motor symptoms by 10-20 years, it has been hypothesized that PD pathology propagates from the ENS to the CNS via the vagal nerve. Discovery of pharmacological and other methods to halt this progression of neurodegeneration in PD has the potential to improve millions of lives. Astrocytes protect neurons in the CNS by secretion of neurotrophic and antioxidative factors. Similarly, astrocyte-like enteric glial cells (EGCs) are known to secrete neuroprotective factors in the ENS. In this article, we summarize the neuroprotective function of astrocytes and EGCs and discuss therapeutic strategies for the prevention of neurodegeneration in PD targeting neurotrophic and antioxidative molecules in glial cells. |
| Keywords | Parkinson’s disease astrocyte enteric glial cell neurotrophic factor antioxidative molecule |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 549 |
| End Page | 556 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703037 |
| Web of Science KeyUT | 000711561600001 |
| NAID | 120007166678 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hamaguchi, Hisashi| Yumoto, Tetsuya| Mae, Soichiro| Takeshita, Ayumu| Aoyama, Minae| Yamana, Keiya| Nakao, Atsunori| |
| Keywords | Hyperostosis diffuse idiopathic skeletal spinal injuries traumatology urinary retention |
| Published Date | 2021-06-23 |
| Publication Title | Clinical Medicine Insights-Case Reports |
| Volume | volume14 |
| Publisher | Sage Publications Ltd |
| Start Page | 1 |
| End Page | 3 |
| ISSN | 1179-5476 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 34248361 |
| DOI | 10.1177/11795476211027988 |
| Web of Science KeyUT | 000688111200001 |
| Related Url | isVersionOf https://doi.org/10.1177/11795476211027988 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsuo, Toshihiko| Uchida, Tetsuya| |
| Keywords | artificial retina retinal prosthesis photoelectric dye polyethylene film monkey surgery multielectrode array dish recording vitrectomy disposable injector sustainable development goals |
| Published Date | 2021 |
| Publication Title | Internal Medicine Review |
| Volume | volume7 |
| Issue | issue1 |
| Publisher | National Library of Medicine |
| ISSN | 2470-3524 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | 2020 Internal Medicine Review. |
| File Version | publisher |
| DOI | 10.18103/imr.v7i1.916 |
| Related Url | isVersionOf http://dx.doi.org/10.18103/imr.v7i1.916 |
| JaLCDOI | 10.18926/AMO/60797 |
|---|---|
| FullText URL | 74_5_381.pdf |
| Author | Yamamoto, Koichiro| Hanayama, Yoshihisa| Hasegawa, Kou| Tokumasu, Kazuki| Miyoshi, Tomoko| Hagiya, Hideharu| Ogawa, Hiroko| Obika, Mikako| Itoshima, Koichi| Otsuka, Fumio| |
| Abstract | To clarify the relevance of prolactin (PRL) to clinical parameters in patients who visited our general medicine department, medical records of 353 patients in whom serum PRL levels were measured during the period from 2016 to 2018 were retrospectively reviewed. Data for 140 patients (M/F: 42/98) were analyzed after excluding patients lacking detailed records and patients taking dopaminergic agents. Median serum PRL levels were significantly lower in males than females: 6.5 ng/ml (IQR: 4.2-10.3) versus 8.1 ng/ml (5.9-12.9), respectively. Pain and general fatigue were the major symptoms at the first visit, and past histories of hypertension and dyslipidemia were frequent. Male patients with relatively high PRL levels (≥ 10 ng/ml) had significantly lower levels of serum albumin and significantly higher levels of serum LDH than those with low PRL (< 10 ng/ml). There were significant correlations of male PRL level with the erythrocyte sedimentation rate (R=0.62), serum LDH level (R=0.39) and serum albumin level (R=−0.52), while the level of serum CRP (R=0.33) showed an insignificant but weak positive correlation with PRL level. Collectively, these results show that PRL levels had gender-specific relevance to various clinical factors, with PRL levels in males being significantly related to inflammatory status. |
| Keywords | hormones hyperprolactinemia inflammation pituitary prolactin |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 381 |
| End Page | 389 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106693 |
| Web of Science KeyUT | 000581970100002 |
| NAID | 120006892923 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sakamoto, Yumi| Okui, Tatsuo| Yoneda, Toshiyuki| Ryumon, Shoji| Nakamura, Tomoya| Kawai, Hotaka| Kunisada, Yuki| Ibaragi, Soichiro| Masui, Masanori| Ono, Kisho| Obata, Kyoichi| Shimo, Tsuyoshi| Sasaki, Akira| |
| Keywords | Oral squamous cell cancer HMGB1 Bone destruction Osteoclasts |
| Published Date | 2020-10-20 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume531 |
| Issue | issue3 |
| Publisher | Elsevier |
| Start Page | 422 |
| End Page | 430 |
| ISSN | 0006-291X |
| NCID | AA00564395 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors |
| File Version | publisher |
| PubMed ID | 32800556 |
| DOI | 10.1016/j.bbrc.2020.07.120 |
| Web of Science KeyUT | 000571663900011 |
| Related Url | isVersionOf https://doi.org/10.1016/j.bbrc.2020.07.120 |
| JaLCDOI | 10.18926/AMO/60368 |
|---|---|
| FullText URL | 74_4_301.pdf |
| Author | Takahashi, Kei| Kitamura, Yoshihisa| Ushio, Soichiro| Sendo, Toshiaki| |
| Abstract | Ketamine has been clinically proven to ameliorate depression, including treatment-resistant depression. The detailed mechanism of action of ketamine in treatment-resistant depression remains unclear. We examined the effects of ketamine on the immobility times of adrenocorticotropic hormone (ACTH)-treated rats during the forced swim test, and we explored the mechanism by which ketamine acts in this model. We investigated the neuroanatomical site of action by microinjecting ketamine into the medial prefrontal cortex of rats. A significant reduction of the rats’ immobility during the forced swim test was observed after the intraperitoneal injection of ketamine in both saline- and ACTH-treated rats. The microinjection of ketamine into the medial prefrontal cortex also decreased immobility during the forced swim test in both saline- and ACTH-treated rats. The immobility-decreasing effect of intraperitoneally injected ketamine was blocked by administering WAY100635, a 5-HT1A receptor antagonist, into the medial prefrontal cortex. These findings contribute to the evidence that ketamine can be useful against treatment-resistant depressive conditions. The immobility-reducing effects of ketamine might be mediated by 5-HT1A receptor activity in the medial prefrontal cortex. |
| Keywords | ketamine adrenocorticotropic hormone forced swim test medial prefrontal cortex 5-HT1A receptor |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 301 |
| End Page | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843761 |
| Web of Science KeyUT | 000562508700005 |
| NAID | 120006880207 |
