start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=1 article-no= start-page=21 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250724 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Market Reactions to Earnings Announcements in Profitable and Loss Firm-Quarters: Changes Around the Market Restructuring kn-title=黒字企業と赤字企業における決算発表に対する市場の反応―市場区分変更前後における分析― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of this paper is to examine whether the market reaction to earnings announcements in each market segment （prime market segment, standard market segment, and growth market segment） differs between profitable and loss-making firms around the time of market restructuring. We have previously studied market reactions to quarterly earnings announcements in the context of the revision of market segmentation at the Tokyo Stock Exchange. However, we have not studied the differences between profitable firm quarters and loss firm quarters. Therefore, the analysis in this paper focuses on whether the net income attributable to owners of the parent is positive or negative. In the growth market segment, significant differences between profitable and loss-making firms were observed in the results of the analysis. en-copyright= kn-copyright= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=1 ORCID= en-aut-name=YamanishiYuki en-aut-sei=Yamanishi en-aut-mei=Yuki kn-aut-name=山西佑季 kn-aut-sei=山西 kn-aut-mei=佑季 aut-affil-num=2 ORCID= en-aut-name=KobayashiHiroaki en-aut-sei=Kobayashi en-aut-mei=Hiroaki kn-aut-name=小林裕明 kn-aut-sei=小林 kn-aut-mei=裕明 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil=熊本県立大学総合管理学部 affil-num=3 en-affil= kn-affil=青山学院大学大学院会計プロフェッション研究科 END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=3 article-no= start-page=1 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250321 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Market Segmentation and Market Reactions to Earnings Announcements: A Quarterly Analysis kn-title=市場区分と決算発表に対する市場の反応 ―四半期データを利用した分析― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of this paper is to examine, using quarterly financial data, how the market reaction to earnings announcements in each market segment （prime market segment, standard market segment, and growth market segment） has changed after the revision of market segmentation at the Tokyo Stock Exchange. For the research design, the abnormal volume and residual returns for the 12 quarters around April 1, 2022, when the market segmentation was changed, were calculated using the analysis method of Beaver et al. ［2020］. The results of the analysis suggest that volume is significantly affected by changes in market segmentation. In addition, for the group of stocks in the growth market, there appears to have been some change in the trend of stock price fluctuations after the market segmentation revision. en-copyright= kn-copyright= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=1 ORCID= en-aut-name=YamanishiYuki en-aut-sei=Yamanishi en-aut-mei=Yuki kn-aut-name=山西佑季 kn-aut-sei=山西 kn-aut-mei=佑季 aut-affil-num=2 ORCID= en-aut-name=KobayashiHiroaki en-aut-sei=Kobayashi en-aut-mei=Hiroaki kn-aut-name=小林裕明 kn-aut-sei=小林 kn-aut-mei=裕明 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil=熊本県立大学総合管理学部 affil-num=3 en-affil= kn-affil=青山学院大学大学院会計プロフェッション研究科 END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Newsletter from Course for Prospective Museum Workers, Faculty of Letters, Okayama University kn-title=学芸員課程 Newsletter 第8号 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=光本順 kn-aut-sei=光本 kn-aut-mei=順 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=坂下奈津紀 kn-aut-sei=坂下 kn-aut-mei=奈津紀 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=土井朱夏 kn-aut-sei=土井 kn-aut-mei=朱夏 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=長谷川奈保 kn-aut-sei=長谷川 kn-aut-mei=奈保 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三島太仁 kn-aut-sei=三島 kn-aut-mei=太仁 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川朋美 kn-aut-sei=中川 kn-aut-mei=朋美 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=新納沙也果 kn-aut-sei=新納 kn-aut-mei=沙也果 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=久野修義 kn-aut-sei=久野 kn-aut-mei=修義 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=森永理恵 kn-aut-sei=森永 kn-aut-mei=理恵 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=文学部 affil-num=2 en-affil= kn-affil=文学部歴史文化学専修コース affil-num=3 en-affil= kn-affil=文学部歴史文化学専修コース affil-num=4 en-affil= kn-affil=文学部歴史文化学専修コース affil-num=5 en-affil= kn-affil=文学部歴史文化学専修コース affil-num=6 en-affil= kn-affil=社会文化科学研究科社会文化学専攻 affil-num=7 en-affil= kn-affil=文学部哲学芸術学専修コース affil-num=8 en-affil= kn-affil=岡山大学大学院社会文化科学研究科・文学部 affil-num=9 en-affil= kn-affil=文学部人文学科言語文化学専修コース END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue= article-no= start-page=33 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240329 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Role of Teachers in the Development of Play Using Grasses and Flowers in a Kindergarten Class for 4-year-olds kn-title=幼稚園４歳児学級における草花を使った遊びの展開に見る教師の役割 en-subtitle= kn-subtitle= en-abstract=This paper aims to organize and examine the role of teachers in the play using grasses and flowers in a kindergarten class for 4-year-olds. In early childhood education, harmonious and diverse learning deepens and develops alongside the development of play, with play and learning seemingly occurring spontaneously and child-directed. However, the roles of teachers, such as “environmental constitution anticipating the child's presence,” “maintenance of the physical environment in accordance with changes in play,” and “bridging to the development of play,” were identified as underlying the background of the development of play and learning. kn-abstract=　本論は，幼稚園４歳児学級における草花を使った遊びにおいて，教師の役割を整理し，考察するものである。幼児教育では，遊びの展開に伴って，調和的で多様な学びが深化・発展し，遊びや学びは，幼児主体で偶発的に生じているように見える。しかし，遊びの展開や学びの背景には，「幼児の姿を予想した環境構成」「遊び方の変化に合わせた物的環境の整備」「遊びの発展への架け橋」といった教師の役割が見出された。 en-copyright= kn-copyright= en-aut-name=YOKOTASaki en-aut-sei=YOKOTA en-aut-mei=Saki kn-aut-name=横田咲樹 kn-aut-sei=横田 kn-aut-mei=咲樹 aut-affil-num=1 ORCID= en-aut-name=NISHIMURA (NAKAGAWA)Kana en-aut-sei=NISHIMURA (NAKAGAWA) en-aut-mei=Kana kn-aut-name=西村（中川）華那 kn-aut-sei=西村（中川） kn-aut-mei=華那 aut-affil-num=2 ORCID= en-aut-name=KATAYAMAMika en-aut-sei=KATAYAMA en-aut-mei=Mika kn-aut-name=片山美香 kn-aut-sei=片山 kn-aut-mei=美香 aut-affil-num=3 ORCID= en-aut-name=TAKAHASHIToshiyuki en-aut-sei=TAKAHASHI en-aut-mei=Toshiyuki kn-aut-name=髙橋敏之 kn-aut-sei=髙橋 kn-aut-mei=敏之 aut-affil-num=4 ORCID= affil-num=1 en-affil=Minan Certified Child Center kn-affil=社会福祉法人橘会 御南認定こども園 affil-num=2 en-affil=Former The Kindergarten Attached to the Faculty of Education, Okayama University kn-affil=元 岡山大学教育学部附属幼稚園 affil-num=3 en-affil=Faculty of Education，Okayama University kn-affil=岡山大学学術研究院教育学域 幼児教育講座 affil-num=4 en-affil=Faculty of Education，Okayama University kn-affil=岡山大学学術研究院教育学域 幼児教育講座 en-keyword=幼稚園 (kindergarten) kn-keyword=幼稚園 (kindergarten) en-keyword=４歳児学級 (4-year-old class) kn-keyword=４歳児学級 (4-year-old class) en-keyword=草花遊び (play using grasses and flowers) kn-keyword=草花遊び (play using grasses and flowers) en-keyword=遊びの展開と学び (development of play and learning) kn-keyword=遊びの展開と学び (development of play and learning) en-keyword=教師の役割 (teacher's role) kn-keyword=教師の役割 (teacher's role) END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue= article-no= start-page=327 end-page=339 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diverse Learning of Children that Can Be Observed during Developing Play with Flowers in the Class of Kindergarten for Four-year-old Children kn-title=幼稚園４歳児学級における草花を使った遊びの展開に見る幼児の多様な学び en-subtitle= kn-subtitle= en-abstract=The purpose of this paper is to clarify the development of play in early childhood education. The learning in childhood is diverse and comprehensive therefore it was difficult to capture the complete picture and it has been empirically understood. Accordingly, we considered play with flowers in the class of kindergarten for four-year-old children. As their play was developed, the learning was deepened, developed, and related to five fields of childcare contents. In addition, the background of learning in childhood that seemed incidental involved effective approaches by te achers. kn-abstract=本論の目的は，幼児教育における遊びの展開を捕捉することである。幼児期の学びは，多様且つ総合的で，全体像の捕捉は困難であり，これまで経験的に理解されてきた。そこで，幼稚園４歳児学級における草花を使った遊びを考察した。遊びの展開に伴って学びは，深化・発展し，保育内容５領域に関係した。偶発的に見える幼児期の学びの背景には，教師の効果的な働きかけがある。 en-copyright= kn-copyright= en-aut-name=YokotaSaki en-aut-sei=Yokota en-aut-mei=Saki kn-aut-name=横田咲樹 kn-aut-sei=横田 kn-aut-mei=咲樹 aut-affil-num=1 ORCID= en-aut-name=NISHIMURA (NAKAGAWA)Kana en-aut-sei=NISHIMURA (NAKAGAWA) en-aut-mei=Kana kn-aut-name=西村（中川）華那 kn-aut-sei=西村（中川） kn-aut-mei=華那 aut-affil-num=2 ORCID= en-aut-name=TakahashiToshiyuki en-aut-sei=Takahashi en-aut-mei=Toshiyuki kn-aut-name=髙橋敏之 kn-aut-sei=髙橋 kn-aut-mei=敏之 aut-affil-num=3 ORCID= affil-num=1 en-affil=Social welfare corporation Tachibana kai Minan Manmaru childcare center kn-affil=社会福祉法人橘会 御南まんまるこども園 affil-num=2 en-affil=Former The Kindergarten Attached to the Faculty of Education, Okayama University kn-affil=元 岡山大学教育学部附属幼稚園 affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 en-keyword=幼児の多様な学び (diverse learning of children) kn-keyword=幼児の多様な学び (diverse learning of children) en-keyword=遊びの展開 (development of play) kn-keyword=遊びの展開 (development of play) en-keyword=幼稚園４歳児学級 (the class of kindergarten for four-year-old children) kn-keyword=幼稚園４歳児学級 (the class of kindergarten for four-year-old children) en-keyword=草花遊び (play with flowers) kn-keyword=草花遊び (play with flowers) END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=3 article-no= start-page=107 end-page=113 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Market Reaction to More Informative Earnings Announcements kn-title=決算発表の充実と市場の反応 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=1 article-no= start-page=1 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220729 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Preliminary Study of the Relationship Between Accounting Fundamentals and Stock Prices for the Prime Market kn-title=プライム市場を対象とした会計のファンダメンタルズと株価の関係に関する予備的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of this paper is to examine the relationship between accounting fundamentals and future abnormal returns for prime market issues on the Tokyo Stock Exchange. The background of the study is the revision of market segmentation in Japan starting April 2022. To elaborate, the market classification on the Tokyo Stock Exchange has been reorganized from the four categories of“ First Section,”“ Second Section,”“ Mothers,” and“ JASDAQ” to three categories of“ Prime Market,”“ Standard Market,” and“ Growth Market.” By examining the relationship between accounting fundamentals and future abnormal returns for prime market stocks, this paper provides empirical evidence on how the introduction of this new market classification affects the relationship between value based on accounting fundamentals and stock prices. en-copyright= kn-copyright= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=1 ORCID= en-aut-name=YamanishiYuki en-aut-sei=Yamanishi en-aut-mei=Yuki kn-aut-name=山西佑季 kn-aut-sei=山西 kn-aut-mei=佑季 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil=熊本県立大学総合管理学部准教授 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=皮膚B細胞リンパ腫とB細胞偽リンパ腫における皮膚FCMを用いたクロナリティの検討：免疫表現型と遺伝子再構成との比較 kn-title=Analysis of clonality in cutaneous B-cell lymphoma and B-cell pseudolymphoma using skin flow cytometry: Comparison of immunophenotyping and gene rearrangement studies　 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaYuki en-aut-sei=Nakagawa en-aut-mei=Yuki kn-aut-name=中川裕貴 kn-aut-sei=中川 kn-aut-mei=裕貴 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Iimoriyama-higashi Mounded Tomb No. 1 -Survey of a mounded tomb with a small stone coffin kn-title=飯盛山東1号墳 －墳丘測量調査・石棺発掘調査報告－ en-subtitle= kn-subtitle= en-abstract= kn-abstract=本書は、岡山市北区芳賀3082番1に所在する飯盛山東1号墳において、2019年3月に行われた墳丘測量調査と石棺の発掘調査報告である。本古墳は周知の埋蔵文化財包蔵地として登録されていたが、名称を持たなかったため、調査に当たり岡山市と協議の上、飯盛山東1号墳の名称を与えた。本調査は、岡山大学考古学研究室が主体となり、清家章（岡山大学大学院社会文化科学研究科教授）が担当して調査を実施した。 en-copyright= kn-copyright= en-aut-name=SeikeAkira en-aut-sei=Seike en-aut-mei=Akira kn-aut-name=清家章 kn-aut-sei=清家 kn-aut-mei=章 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=清山隆 kn-aut-sei=清山 kn-aut-mei=隆 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=阿部誠悟 kn-aut-sei=阿部 kn-aut-mei=誠悟 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川朋美 kn-aut-sei=中川 kn-aut-mei=朋美 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=額田千夏 kn-aut-sei=額田 kn-aut-mei=千夏 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=坂本稔 kn-aut-sei=坂本 kn-aut-mei=稔 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=瀧上舞 kn-aut-sei=瀧上 kn-aut-mei=舞 aut-affil-num=7 ORCID= affil-num=1 en-affil=The Department of Archaeology, Okayama University kn-affil=岡山大学大学院社会文化科学研究科考古学研究室 affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= affil-num=4 en-affil= kn-affil= affil-num=5 en-affil= kn-affil= affil-num=6 en-affil= kn-affil=国立歴史民俗博物館 affil-num=7 en-affil= kn-affil=国立科学博物館 END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue= article-no= start-page=1 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=水汲み問題をめぐって en-subtitle= kn-subtitle= en-abstract= kn-abstract=現行の多くの中学校1年生用の教科書の中で取り上げられている「水汲み問題」について，その内容の数学的な豊かさ，面白さを概観し，併せて，この問題が持つ教材開発の可能性について考察する． en-copyright= kn-copyright= en-aut-name=なかがわまさき en-aut-sei=なかがわ en-aut-mei=まさき kn-aut-name=中川征樹 kn-aut-sei=中川 kn-aut-mei=征樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院教育学研究科 en-keyword=水汲み問題 kn-keyword=水汲み問題 en-keyword=最短経路問題 kn-keyword=最短経路問題 en-keyword=最大・最小問題 kn-keyword=最大・最小問題 en-keyword=初等幾何学 kn-keyword=初等幾何学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210506 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=難聴をもつ小・中・高校生の学校生活で大切なこと : 先生編 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaYuko en-aut-sei=Kataoka en-aut-mei=Yuko kn-aut-name=片岡祐子 kn-aut-sei=片岡 kn-aut-mei=祐子 aut-affil-num=1 ORCID= en-aut-name=NakagawaAtsuko en-aut-sei=Nakagawa en-aut-mei=Atsuko kn-aut-name=中川敦子 kn-aut-sei=中川 kn-aut-mei=敦子 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院 耳鼻咽喉科 affil-num=2 en-affil= kn-affil=岡山大学病院 耳鼻咽喉科 END start-ver=1.4 cd-journal=joma no-vol=175 cd-vols= no-issue= article-no= start-page=1 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20201127 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=幼稚園における「言葉による伝え合い」の力を育む「振り返り」の時間の意義と課題 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　本稿では，まず，平成29（2017）年に改訂（改定）された幼稚園教育要領に提示された，これからの時代を生き抜くために幼児教育において育てたい資質・能力としての三つの柱を示すと共に，その育成に際して「言葉」の力を育む重要性について述べた。続いて，３つの資質・能力の育成を目指しつつ，子どもが５領域を通じた経験を積み重ねることによって幼稚園修了時に育まれるとされる「言葉による伝え合い」に焦点を当て，幼稚園生活における「言葉による伝え合い」の場と年齢別の姿を描出した。さらに，幼稚園生活の中でほぼ毎日，「言葉による伝え合い」を交えて実践されている「振り返り」の時間を取り上げ，幼児や教師にとっての意義，及び有用な「振り返り」に求められる教師の専門性について論じた。幼児にとっては，ある体験の前後で自らの違いに気付いて学びを自覚したり，小学校での学び方の型を身に付けたりする機会として，教師にとっては新たな幼児理解，適切な環境構成の手がかりとしての意義があることを論じた。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片山美香 kn-aut-sei=片山 kn-aut-mei=美香 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西村華那 kn-aut-sei=西村 kn-aut-mei=華那 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院教育学研究科　発達支援学系 affil-num=2 en-affil= kn-affil=学校法人　大阪慈幸学園　中野幼稚園 en-keyword=言葉による伝え合い kn-keyword=言葉による伝え合い en-keyword=振り返り kn-keyword=振り返り en-keyword=幼稚園 kn-keyword=幼稚園 en-keyword=教師 kn-keyword=教師 en-keyword=言語力の育成 kn-keyword=言語力の育成 END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=1 article-no= start-page=1 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200703 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Accounting Research and Fundamental Analysis kn-title=会計研究とファンダメンタル分析 en-subtitle= kn-subtitle= en-abstract= kn-abstract= The purpose of this paper is to examine fundamental analysis from an accounting perspective and clarify its value and significance. For that purpose, I focus on quantitative investment strategies, capital market research in accounting, accounting anomalies, mispricing, and research paths. Fundamental analysis is one of the important directions in empirical accounting research that has been studied since Ball and Brown（ 1968）. Fundamental analysis influences neighboring research areas, and thus it should not be ignored or downplayed in accounting research because of the dissemination of quantitative investment strategies. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院社会文化科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=先史時代における暴力の文化的背景 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaTomomi en-aut-sei=Nakagawa en-aut-mei=Tomomi kn-aut-name=中川朋美 kn-aut-sei=中川 kn-aut-mei=朋美 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Humanities and Social Sciences, Okayama University kn-affil=岡山大学大学院社会文化科学研究科 END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=23 article-no= start-page=5885 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20191123 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Current Treatment Strategies and Nanoparticle-Mediated Drug Delivery Systems for Pulmonary Arterial Hypertension en-subtitle= kn-subtitle= en-abstract= kn-abstract=There are three critical pathways for the pathogenesis and progression of pulmonary arterial hypertension (PAH): the prostacyclin (prostaglandin I-2) (PGI(2)), nitric oxide (NO), and endothelin pathways. The current approved drugs targeting these three pathways, including prostacyclin (PGI(2)), phosphodiesterase type-5 (PDE5) inhibitors, and endothelin receptor antagonists (ERAs), have been shown to be effective, however, PAH remains a severe clinical condition and the long-term survival of patients with PAH is still suboptimal. The full therapeutic abilities of available drugs are reduced by medication, patient non-compliance, and side effects. Nanoparticles are expected to address these problems by providing a novel drug delivery approach for the treatment of PAH. Drug-loaded nanoparticles for local delivery can optimize the efficacy and minimize the adverse effects of drugs. Prostacyclin (PGI(2)) analogue, PDE5 inhibitors, ERA, pitavastatin, imatinib, rapamycin, fasudil, and oligonucleotides-loaded nanoparticles have been reported to be effective in animal PAH models and in vitro studies. However, the efficacy and safety of nanoparticle mediated-drug delivery systems for PAH treatment in humans are unknown and further clinical studies are required to clarify these points. en-copyright= kn-copyright= en-aut-name=NakamuraKazufumi en-aut-sei=Nakamura en-aut-mei=Kazufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AkagiSatoshi en-aut-sei=Akagi en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=EjiriKentaro en-aut-sei=Ejiri en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshidaMasashi en-aut-sei=Yoshida en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyoshiToru en-aut-sei=Miyoshi en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TohNorihisa en-aut-sei=Toh en-aut-mei=Norihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakagawaKoji en-aut-sei=Nakagawa en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakayaYoichi en-aut-sei=Takaya en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MatsubaraHiromi en-aut-sei=Matsubara en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ItoHiroshi en-aut-sei=Ito en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil= Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil= Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil= Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil= Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Division of Cardiology, National Hospital Organization Okayama Medical Center kn-affil= affil-num=10 en-affil= Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=pulmonary arterial hypertension kn-keyword=pulmonary arterial hypertension en-keyword=prostaglandin I-2 kn-keyword=prostaglandin I-2 en-keyword=nitric oxide kn-keyword=nitric oxide en-keyword=endothelin kn-keyword=endothelin END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue=2-3 article-no= start-page=1 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200319 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Preliminary Study on Classification of Financial Ratios Using Factor Analysis kn-title=因子分析による財務比率の分類に関する予備的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of this paper is to perform factor analysis on financial ratios calculated using consolidated financial statement data from the fiscal year ended March 31, 2006 to the fiscal year ended March 31, 2017, which are disclosed by Japanese companies, and to classify financial ratios.
　The analysis provided evidence to suggest that both net income and cash flows from operating activities are functioned as financial performance measures with similar properties. We also find that capital efficiency is an important factor. Furthermore, there is also evidence that cash flows from investing activities and cash flows from financing activities have a common factor. en-copyright= kn-copyright= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=1 ORCID= en-aut-name=NagahataHidekazu en-aut-sei=Nagahata en-aut-mei=Hidekazu kn-aut-name=長畑秀和 kn-aut-sei=長畑 kn-aut-mei=秀和 aut-affil-num=2 ORCID= en-aut-name=YamanishiYuki en-aut-sei=Yamanishi en-aut-mei=Yuki kn-aut-name=山西佑季 kn-aut-sei=山西 kn-aut-mei=佑季 aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Humanities and Social Sciences, Okayama University kn-affil=岡山大学大学院社会文化科学研究科 affil-num=2 en-affil=Graduate School of Humanities and Social Sciences, Okayama University kn-affil=岡山大学大学院社会文化科学研究科 affil-num=3 en-affil= kn-affil=熊本県立大学総合管理学部 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue= article-no= start-page=93 end-page=111 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190322 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Key Factors of Growth over the Industry Lifecycle kn-title=ライフサイクルを考慮した企業の成長要因 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KoshidaTakahisa en-aut-sei=Koshida en-aut-mei=Takahisa kn-aut-name=越田孝久 kn-aut-sei=越田 kn-aut-mei=孝久 aut-affil-num=1 ORCID= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=2 ORCID= en-aut-name=NagahataHidekazu en-aut-sei=Nagahata en-aut-mei=Hidekazu kn-aut-name=長畑秀和 kn-aut-sei=長畑 kn-aut-mei=秀和 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院社会文化科学研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院社会文化科学研究科 affil-num=3 en-affil= kn-affil=岡山大学大学院社会文化科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=真菌二次代謝産物である(+)-terreinがマウス骨髄由来マクロファージにおいてRANKL誘導性破骨細胞分化に及ぼす影響と標的分子の解明 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaSaki en-aut-sei=Nakagawa en-aut-mei=Saki kn-aut-name=中川沙紀 kn-aut-sei=中川 kn-aut-mei=沙紀 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=166 cd-vols= no-issue= article-no= start-page=31 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20171128 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Attempt to Analyze the Transformation in the Concept of the Environment during Class Practice for a Childcare Contents “Environment” kn-title=保育内容「環境」の授業実践における 環境概念の変容を捉える試み en-subtitle= kn-subtitle= en-abstract= kn-abstract=　“Environmentˮ has special meanings in early childhood education and care in Japan. The present study, we identified characteristic that is a problem faced by students in understanding the concept of the environment in a class on child care in the context of the “environmentˮ in a training school for child care providers. Specifically, this study used a sentence completion test to detect the transformation in the concept of environment in the students. These data were quantitatively analyzed using text mining. In addition, we examined the transformation in the environmental concept qualitatively. As a result, the tendency to use the captured environment as a method was seen, and some characteristics became clear. Based on these findings, we considered it necessary for class improvement to be expedited. en-copyright= kn-copyright= en-aut-name=NishiyamaOsamu en-aut-sei=Nishiyama en-aut-mei=Osamu kn-aut-name=西山修 kn-aut-sei=西山 kn-aut-mei=修 aut-affil-num=1 ORCID= en-aut-name=OkamuraSachiyo en-aut-sei=Okamura en-aut-mei=Sachiyo kn-aut-name=岡村幸代 kn-aut-sei=岡村 kn-aut-mei=幸代 aut-affil-num=2 ORCID= en-aut-name=NakagawaTomoyuki en-aut-sei=Nakagawa en-aut-mei=Tomoyuki kn-aut-name=中川智之 kn-aut-sei=中川 kn-aut-mei=智之 aut-affil-num=3 ORCID= en-aut-name=KatayamaMika en-aut-sei=Katayama en-aut-mei=Mika kn-aut-name=片山美香 kn-aut-sei=片山 kn-aut-mei=美香 aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科 affil-num=2 en-affil=Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科 affil-num=3 en-affil=Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科 affil-num=4 en-affil=Graduate School of Education, Okayama University kn-affil=岡山大学大学院教育学研究科 END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=2 article-no= start-page=111 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Adenocarcinoma in the jejunum 20 years after surgery for familial adenomatous polyposis kn-title=家族性大腸腺腫症術後20年後に小腸癌を発症した1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 58-year-old Japanese man visited a local clinic for the evaluation of a stomachache. He was diagnosed with intestinal obstruction. His medical history included a proctocolectomy at the age of 38 years, due to familial adenomatous polyposis (FAP). He was referred to our institution, where he underwent a computed tomography examination and endoscopy of the small intestine. The pathological diagnosis was adenocarcinoma. No invasive or metastatic lesions were observed. Therefore, partial resection of the ileum with lymphadenectomy and reconstruction of the ileostomy were performed. Pathological examination revealed that the tumor was type 2, pT3 (SS) , pN1, pPM0, pDM0, pRM0, INFb, ly1, v1, pEX0, PN0. Twenty-nine days after the surgery, the patient was diagnosed with lung metastasis and he underwent lung radiofrequency ablation. We suggest that long-term follow-up is necessary for patients after surgery for FAP, because of the risk of malignant disease developing in other organs. en-copyright= kn-copyright= en-aut-name=SugiharaYuusaku en-aut-sei=Sugihara en-aut-mei=Yuusaku kn-aut-name=杉原雄策 kn-aut-sei=杉原 kn-aut-mei=雄策 aut-affil-num=1 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=川野誠司 kn-aut-sei=川野 kn-aut-mei=誠司 aut-affil-num=2 ORCID= en-aut-name=HaradaKeita en-aut-sei=Harada en-aut-mei=Keita kn-aut-name=原田馨太 kn-aut-sei=原田 kn-aut-mei=馨太 aut-affil-num=3 ORCID= en-aut-name=TakashimaShiho en-aut-sei=Takashima en-aut-mei=Shiho kn-aut-name=高嶋志保 kn-aut-sei=高嶋 kn-aut-mei=志保 aut-affil-num=4 ORCID= en-aut-name=TakeiDaisuke en-aut-sei=Takei en-aut-mei=Daisuke kn-aut-name=竹井大介 kn-aut-sei=竹井 kn-aut-mei=大介 aut-affil-num=5 ORCID= en-aut-name=InokuchiToshihiro en-aut-sei=Inokuchi en-aut-mei=Toshihiro kn-aut-name=井口俊博 kn-aut-sei=井口 kn-aut-mei=俊博 aut-affil-num=6 ORCID= en-aut-name=TakaharaMasahiro en-aut-sei=Takahara en-aut-mei=Masahiro kn-aut-name=高原政宏 kn-aut-sei=高原 kn-aut-mei=政宏 aut-affil-num=7 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name=平岡佐規子 kn-aut-sei=平岡 kn-aut-mei=佐規子 aut-affil-num=8 ORCID= en-aut-name=MoriYoshiko en-aut-sei=Mori en-aut-mei=Yoshiko kn-aut-name=母里淑子 kn-aut-sei=母里 kn-aut-mei=淑子 aut-affil-num=9 ORCID= en-aut-name=KishimotoHiroyuki en-aut-sei=Kishimoto en-aut-mei=Hiroyuki kn-aut-name=岸本浩行 kn-aut-sei=岸本 kn-aut-mei=浩行 aut-affil-num=10 ORCID= en-aut-name=NagasakaTakeshi en-aut-sei=Nagasaka en-aut-mei=Takeshi kn-aut-name=永坂岳司 kn-aut-sei=永坂 kn-aut-mei=岳司 aut-affil-num=11 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=3 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=5 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 affil-num=9 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=10 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=11 en-affil=Division of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　消化管外科 affil-num=12 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil=岡山大学病院　消化器内科 en-keyword=家族性大腸腺腫症 (familial adenomatous polyposis) kn-keyword=家族性大腸腺腫症 (familial adenomatous polyposis) en-keyword=小腸癌 (jejunal cancer) kn-keyword=小腸癌 (jejunal cancer) en-keyword=小腸内視鏡検査 (small intestine endoscope) kn-keyword=小腸内視鏡検査 (small intestine endoscope) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=固定性架工義歯と可撤性部分床義歯の治療効果判定のための口腔関連QOL質問票とその最小有効差 : 最小有効差の測定に及ぼす天井効果とレスポンスシフトの影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaShinsuke en-aut-sei=Nakagawa en-aut-mei=Shinsuke kn-aut-name=中川晋輔 kn-aut-sei=中川 kn-aut-mei=晋輔 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=191 end-page=196 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Our experience with the significance of collaborative medical and dental surgeries at the Head and Neck Cancer Center, Okayama University Hospital kn-title=岡山大学病院頭頸部がんセンターにおける医科歯科合同手術の現状解析とその意義 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　　We have been collaborating with head and neck surgeons, plastic surgeons and oral surgeons in surgeries for many patients with head and neck carcinomas（ especially oral carcinomas） since 2006（ fiscal year 2005）. The Head and Neck Cancer Center was established at Okayama University Hospital in 2012. 　This Center was the first of its kind at a national university hospital in Japan. 　At the Center, 174 operations on head and neck carcinomas and 96 reconstructive operations were performed in 2014（ fiscal year）. 　Medical and dental collaborative operations have been increasing almost every year since the 2005 fiscal year. There were 45 collaborative operations in the 2014 fiscal year, which included 30 cases of bone or metal plate reconstruction or plate reinforcement of the jaws. 　There were 76 medical and dental collaborative operations in the 7 years before the establishment of the Center, with a mean of 10.9 operations per year. Since the establishment of the Center, there have been 112 cases over 3 years with a mean of 37.3 operations per year. The number of surgeries has been markedly increased by the establishment of the Head and Neck Cancer Center. en-copyright= kn-copyright= en-aut-name=MizukawaNobuyoshi en-aut-sei=Mizukawa en-aut-mei=Nobuyoshi kn-aut-name=水川展吉 kn-aut-sei=水川 kn-aut-mei=展吉 aut-affil-num=1 ORCID= en-aut-name=OnodaTomoo en-aut-sei=Onoda en-aut-mei=Tomoo kn-aut-name=小野田友男 kn-aut-sei=小野田 kn-aut-mei=友男 aut-affil-num=2 ORCID= en-aut-name=MatsumotoHiroshi en-aut-sei=Matsumoto en-aut-mei=Hiroshi kn-aut-name=松本洋 kn-aut-sei=松本 kn-aut-mei=洋 aut-affil-num=3 ORCID= en-aut-name=TakedaSeiko en-aut-sei=Takeda en-aut-mei=Seiko kn-aut-name=武田斉子 kn-aut-sei=武田 kn-aut-mei=斉子 aut-affil-num=4 ORCID= en-aut-name=NodaYouhei en-aut-sei=Noda en-aut-mei=Youhei kn-aut-name=野田洋平 kn-aut-sei=野田 kn-aut-mei=洋平 aut-affil-num=5 ORCID= en-aut-name=OnodaSatoshi en-aut-sei=Onoda en-aut-mei=Satoshi kn-aut-name=小野田聡 kn-aut-sei=小野田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=FukushimaMai en-aut-sei=Fukushima en-aut-mei=Mai kn-aut-name=福島麻衣 kn-aut-sei=福島 kn-aut-mei=麻衣 aut-affil-num=7 ORCID= en-aut-name=TsumuraMunechika en-aut-sei=Tsumura en-aut-mei=Munechika kn-aut-name=津村宗近 kn-aut-sei=津村 kn-aut-mei=宗近 aut-affil-num=8 ORCID= en-aut-name=TakeuchiTetsuo en-aut-sei=Takeuchi en-aut-mei=Tetsuo kn-aut-name=竹内哲男 kn-aut-sei=竹内 kn-aut-mei=哲男 aut-affil-num=9 ORCID= en-aut-name=SugiyamaNarushi en-aut-sei=Sugiyama en-aut-mei=Narushi kn-aut-name=杉山成史 kn-aut-sei=杉山 kn-aut-mei=成史 aut-affil-num=10 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name=木股敬裕 kn-aut-sei=木股 kn-aut-mei=敬裕 aut-affil-num=11 ORCID= affil-num=1 en-affil=Departments of Oral and Maxillofacial Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=岡山大学病院　頭頸部がんセンター， 顎口腔再建外科 affil-num=2 en-affil=Departments of Otorhinolaryngology, Head and Neck Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=岡山大学病院　頭頸部がんセンター，耳鼻咽喉・頭頸部外科 affil-num=3 en-affil=Departments of Plastic and Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=岡山大学病院　頭頸部がんセンター，形成外科 affil-num=4 en-affil=Departments of Oral and Maxillofacial Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=岡山大学病院　頭頸部がんセンター，顎口腔再建外科 affil-num=5 en-affil=Departments of Otorhinolaryngology, Head and Neck Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=岡山大学病院　頭頸部がんセンター，耳鼻咽喉・頭頸部外科 affil-num=6 en-affil=Departments of Plastic and Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=岡山大学病院　頭頸部がんセンター，形成外科 affil-num=7 en-affil=Departments of Oral and Maxillofacial Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=岡山大学病院　頭頸部がんセンター，顎口腔再建外科 affil-num=8 en-affil=Departments of Otorhinolaryngology, Head and Neck Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=岡山大学病院　頭頸部がんセンター，耳鼻咽喉・頭頸部外科 affil-num=9 en-affil=Departments of Dental Laboratory, Head and Neck Cancer Center, Okayama University Hospital kn-affil=岡山大学病院　頭頸部がんセンター，歯科技工室 affil-num=10 en-affil=Departments of Plastic and Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=岡山大学病院　頭頸部がんセンター，形成外科 affil-num=11 en-affil=Departments of Plastic and Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital kn-affil=岡山大学病院　頭頸部がんセンター，形成外科 en-keyword=頭頸部がん（head and neck carcinoma） kn-keyword=頭頸部がん（head and neck carcinoma） en-keyword=口腔がん（oral carcinoma） kn-keyword=口腔がん（oral carcinoma） en-keyword=頭頸部がんセンター（Head and Neck Cancer Center） kn-keyword=頭頸部がんセンター（Head and Neck Cancer Center） en-keyword=医科歯科合同手術（collaborative medical and dental surgeries） kn-keyword=医科歯科合同手術（collaborative medical and dental surgeries） en-keyword=顎骨再建（reconstructive operations of the jaw） kn-keyword=顎骨再建（reconstructive operations of the jaw） END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=5 article-no= start-page=397 end-page=400 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Feasibility of Repairing Defects Followed by Treatment with Pulmonary Hypertension-specific Drugs (Repair and Treat) in Patients with Pulmonary Hypertension Associated with Atrial Septal Defect: Study Protocol for Interventional Trial en-subtitle= kn-subtitle= en-abstract= kn-abstract=A treatment strategy for patients with pulmonary hypertension (PH) and atrial septal defect (ASD) remains unclear. This study was designed to evaluate the effects of initial repair of ASD followed by treatment with PH-specific drugs in patients with PH and ASD. Eligible patients receive transcatheter ASD closure followed by treatment with bosentan and sildenafil. Right heart catheterization is performed at baseline and at 12, 24 and 48 weeks. The primary endpoint is change in pulmonary artery pressure and pulmonary vascular resistance from baseline to follow-up. This study should provide valuable information to establish a therapeutic strategy for PH and ASD. en-copyright= kn-copyright= en-aut-name=AkagiSatoshi en-aut-sei=Akagi en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakamuraKazufumi en-aut-sei=Nakamura en-aut-mei=Kazufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AkagiTeiji en-aut-sei=Akagi en-aut-mei=Teiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakagawaKoji en-aut-sei=Nakagawa en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakayaYoichi en-aut-sei=Takaya en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SarashinaToshihiro en-aut-sei=Sarashina en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=EjiriKentaro en-aut-sei=Ejiri en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ItoHiroshi en-aut-sei=Ito en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=2 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=3 en-affil=Cardiac Intensive Care Unit, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=5 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=6 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=7 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=8 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= en-keyword=pulmonary hypertension kn-keyword=pulmonary hypertension en-keyword=atrial septal defect kn-keyword=atrial septal defect en-keyword=repair and treat kn-keyword=repair and treat en-keyword=transcatheter closure kn-keyword=transcatheter closure END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=3 article-no= start-page=173 end-page=184 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160319 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Analysis of Accruals and Management Earnings Forecast Revisions kn-title=会計発生高と経営者予想利益の修正に関する分析 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=1 ORCID= en-aut-name=YamanishiYuuki en-aut-sei=Yamanishi en-aut-mei=Yuuki kn-aut-name=山西佑季 kn-aut-sei=山西 kn-aut-mei=佑季 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=熊本県立大学 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=2 article-no= start-page=129 end-page=140 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160223 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=What is Value Relevance? kn-title=Value Relevanceとは何か en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=1 article-no= start-page=53 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction (35. Opioid-analgesic drug interactions) kn-title=薬物相互作用 (35―オピオイド鎮痛薬の薬物相互作用） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SadaHikaru en-aut-sei=Sada en-aut-mei=Hikaru kn-aut-name=佐田光 kn-aut-sei=佐田 kn-aut-mei=光 aut-affil-num=1 ORCID= en-aut-name=KajizonoMakoto en-aut-sei=Kajizono en-aut-mei=Makoto kn-aut-name=鍛治園誠 kn-aut-sei=鍛治園 kn-aut-mei=誠 aut-affil-num=2 ORCID= en-aut-name=KitamuraYoshihisa en-aut-sei=Kitamura en-aut-mei=Yoshihisa kn-aut-name=北村佳久 kn-aut-sei=北村 kn-aut-mei=佳久 aut-affil-num=3 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=2 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=3 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=4 en-affil= kn-affil=岡山大学病院　薬剤部 END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=1 article-no= start-page=21 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of mucinous adenocarcinoma of the duodenum and literature review of 16 cases reported in Japan kn-title=原発性十二指腸粘液癌の一例― 本邦報告16例の検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Primary mucinous adenocarcinoma of the duodenum is rare. Here we report a case we recently encountered, and we review 16 cases reported in Japan. An 82-year-old Japanese woman was admitted to our hospital complaining of abdominal pain and heartburn. An endoscopic examination revealed a Type 2 tumor in the descending limb of the duodenum, and endoscopically obtained specimens revealed a poorly differentiated adenocarcinoma. We performed a curative pancreatoduodenectomy with lymph node resection, and the surgical specimen revealed that the duodenum was the primary site of the mucinous adenocarcinoma. The patient is currently alive ＞ 1 year after the operation without any evidence of recurrence. Of the 16 patients reviewed, all patients had advanced tumors those depth were T3-T4. 9 patients had lymph node metastasis and 4 patients had peritoneal dissemination at the time of surgery. Since mucinous adenocarcinoma of the duodenum is often progressive cancer at a diagnosis, which is tend to have a worse prognosis than other histological types. en-copyright= kn-copyright= en-aut-name=HamanoIkumi en-aut-sei=Hamano en-aut-mei=Ikumi kn-aut-name=浜野郁美 kn-aut-sei=浜野 kn-aut-mei=郁美 aut-affil-num=1 ORCID= en-aut-name=MatsumotoYusuke en-aut-sei=Matsumoto en-aut-mei=Yusuke kn-aut-name=松本祐介 kn-aut-sei=松本 kn-aut-mei=祐介 aut-affil-num=2 ORCID= en-aut-name=EndoYoshikatsu en-aut-sei=Endo en-aut-mei=Yoshikatsu kn-aut-name=遠藤芳克 kn-aut-sei=遠藤 kn-aut-mei=芳克 aut-affil-num=3 ORCID= en-aut-name=WatanabeNaoki en-aut-sei=Watanabe en-aut-mei=Naoki kn-aut-name=渡邊直樹 kn-aut-sei=渡邊 kn-aut-mei=直樹 aut-affil-num=4 ORCID= en-aut-name=KaiKyouhei en-aut-sei=Kai en-aut-mei=Kyouhei kn-aut-name=甲斐恭平 kn-aut-sei=甲斐 kn-aut-mei=恭平 aut-affil-num=5 ORCID= en-aut-name=SatoShizou en-aut-sei=Sato en-aut-mei=Shizou kn-aut-name=佐藤四三 kn-aut-sei=佐藤 kn-aut-mei=四三 aut-affil-num=6 ORCID= en-aut-name=WaniYoji en-aut-sei=Wani en-aut-mei=Yoji kn-aut-name=和仁洋治 kn-aut-sei=和仁 kn-aut-mei=洋治 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=2 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=3 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=4 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=5 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=6 en-affil= kn-affil=姫路赤十字病院　外科 affil-num=7 en-affil= kn-affil=姫路赤十字病院　病理診断科 en-keyword=原発性十二指腸癌（primary duodenal cancer） kn-keyword=原発性十二指腸癌（primary duodenal cancer） en-keyword=粘液癌（mucinous carcinoma） kn-keyword=粘液癌（mucinous carcinoma） en-keyword=膵頭十二指腸切除（pancreatoduodenectomy） kn-keyword=膵頭十二指腸切除（pancreatoduodenectomy） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=卵巣子宮内膜症と上皮性卵巣腫瘍の組織学的サブタイプにおけるCA19 -9と CA125の反応性 kn-title=Reactivity of CA19-9 and CA125 in Histological Subtypes of Epithelial Ovarian Tumors and Ovarian Endometriosis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaNaohisa en-aut-sei=Nakagawa en-aut-mei=Naohisa kn-aut-name=中川尚久 kn-aut-sei=中川 kn-aut-mei=尚久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=1 article-no= start-page=31 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150702 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Development of Studies for Accounting Anomalies and Market Efficiency kn-title=会計アノマリー研究の進展と市場の効率性 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=1 article-no= start-page=25 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laparoscopic total colectomy with lymph node dissection for familial adenomatous polyposis with multiple colorectal cancers kn-title=家族性大腸腺腫症（FAP）に合併した同時性５多発大腸癌に対してリンパ節郭清を伴う腹腔鏡下大腸全摘術を施行した１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 49-year-old Japanese man visited our hospital with chief complaints of difficulty with and bleeding during defecation. After a detailed examination, he was diagnosed with familial adenomatous polyposis (FAP) with multiple (five) colorectal cancers. The tumors were located in the right-sided, left-sided, and sigmoid colon, and the lower rectum. Regional lymph node involvement was observed, but no metastasis to other organs was detected. We, therefore, performed a laparoscopic total colectomy with superior mesenteric artery (SMA) and inferior mesenteric artery (IMA) lymph node dissection. We were able to perform minimally invasive and cosmetically acceptable surgery using laparoscopy instead of highly-invasive open abdominal surgery. Our search of the literature revealed no reported cases of laparoscopic total colectomy with lymph node dissection for FAP with multiple colorectal cancers, making the present case the first to be reported in the literature. en-copyright= kn-copyright= en-aut-name=KatoHiroshi en-aut-sei=Kato en-aut-mei=Hiroshi kn-aut-name=加藤大 kn-aut-sei=加藤 kn-aut-mei=大 aut-affil-num=1 ORCID= en-aut-name=OishiMasahiro en-aut-sei=Oishi en-aut-mei=Masahiro kn-aut-name=大石正博 kn-aut-sei=大石 kn-aut-mei=正博 aut-affil-num=2 ORCID= en-aut-name=KoderaMasahito en-aut-sei=Kodera en-aut-mei=Masahito kn-aut-name=小寺正人 kn-aut-sei=小寺 kn-aut-mei=正人 aut-affil-num=3 ORCID= en-aut-name=YamamuraMasao en-aut-sei=Yamamura en-aut-mei=Masao kn-aut-name=山村方夫 kn-aut-sei=山村 kn-aut-mei=方夫 aut-affil-num=4 ORCID= en-aut-name=IkedaHideaki en-aut-sei=Ikeda en-aut-mei=Hideaki kn-aut-name=池田秀明 kn-aut-sei=池田 kn-aut-mei=秀明 aut-affil-num=5 ORCID= en-aut-name=MizunoKenji en-aut-sei=Mizuno en-aut-mei=Kenji kn-aut-name=水野憲治 kn-aut-sei=水野 kn-aut-mei=憲治 aut-affil-num=6 ORCID= en-aut-name=YamashitaYutaka en-aut-sei=Yamashita en-aut-mei=Yutaka kn-aut-name=山下裕 kn-aut-sei=山下 kn-aut-mei=裕 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=鳥取市立病院　外科 affil-num=2 en-affil= kn-affil=鳥取市立病院　外科 affil-num=3 en-affil= kn-affil=鳥取市立病院　外科 affil-num=4 en-affil= kn-affil=鳥取市立病院　外科 affil-num=5 en-affil= kn-affil=鳥取市立病院　外科 affil-num=6 en-affil= kn-affil=鳥取市立病院　外科 affil-num=7 en-affil= kn-affil=鳥取市立病院　外科 en-keyword=家族性大腸腺腫症（FAP）（familial adenomatous polyposis） kn-keyword=家族性大腸腺腫症（FAP）（familial adenomatous polyposis） en-keyword=同時性多発大腸癌（synchronous colorectal cancer） kn-keyword=同時性多発大腸癌（synchronous colorectal cancer） en-keyword=大腸全摘術（colorectal surgery） kn-keyword=大腸全摘術（colorectal surgery） en-keyword=腹腔鏡下手術（laparoscopic surgery） kn-keyword=腹腔鏡下手術（laparoscopic surgery） END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=73 end-page=82 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study for Significance of Child Expression Activity by Music and Support of Childcare Worker　For Fostering Interpersonal Relationships of Children kn-title=音楽による幼児の表現活動の意義と保育者の援助に関する研究　― 人とかかわる力を育むために ― en-subtitle= kn-subtitle= en-abstract= kn-abstract=　音楽は，園生活の中で領域「表現」の活動の一つとして取り入れられているが，活動の在り方は様々である。 本研究では，園生活における観察から，幼児の自発的な音楽を介した表現の実態を明らかにすることを試みた。 その結果，幼児が自分の感情や状況を歌詞になぞらえたりして，自発的に音楽を介した表現を行う姿が見られた。 音楽を介した表現によって，自他の感情調整の役割を果たすことが明らかになった。また，歌詞に合わせた身体 表現は，未熟な言語力を補完する役割を担っていた。共通に知っている歌は表現したい意図や，感情を共有する 際の媒体となって，幼児間のコミュニケーションを円滑にする役割も担っていることが示された。 　幼児の自発的な表現を引き出すためには，保育者が音楽技術の習得を目指した指導的なかかわりをするのでは なく，音楽を介した自己表現として肯定的に受け止め，応答する援助が欠かせないことが明らかにされた。 en-copyright= kn-copyright= en-aut-name=NakagawaKana en-aut-sei=Nakagawa en-aut-mei=Kana kn-aut-name=中川華那 kn-aut-sei=中川 kn-aut-mei=華那 aut-affil-num=1 ORCID= en-aut-name=KatayamaMika en-aut-sei=Katayama en-aut-mei=Mika kn-aut-name=片山美香 kn-aut-sei=片山 kn-aut-mei=美香 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山市立伊島幼稚園 affil-num=2 en-affil= kn-affil=岡山大学大学院教育学研究科 en-keyword=幼児 kn-keyword=幼児 en-keyword=音楽 kn-keyword=音楽 en-keyword=自己表現 kn-keyword=自己表現 en-keyword=援助 kn-keyword=援助 END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=2 article-no= start-page=119 end-page=131 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20141218 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Relations Between Management Earnings Forecast Revisions and Returns kn-title=経営者予想利益の修正とリターンの関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=1 ORCID= en-aut-name=YamanishiYuuki en-aut-sei=Yamanishi en-aut-mei=Yuuki kn-aut-name=山西佑季 kn-aut-sei=山西 kn-aut-mei=佑季 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=熊本県立大学総合管理学部 END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=3 article-no= start-page=33 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131220 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Post-Earnings Announcement Drift and Accruals Anomaly kn-title=利益発表後ドリフトと会計発生高アノマリー en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=3 article-no= start-page=239 end-page=242 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of appendiceal diverticulum resected by laparoscopic surgery with preoperative diagnosis of appendiceal tumor kn-title=虫垂腫瘍と術前診断し腹腔鏡下手術を行った虫垂仮性憩室症の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Appendiceal diverticulum is rare. We encountered a case of appendiceal diverticulum with chronic appendicitis. A 56-year-old man presented to our hospital with right lower abdominal pain. An abdominal computed tomography (CT) scan showed swelling of the appendix body and the wall thickness of the base of the appendix. Due to the possibility of appendiceal tumor, we performed a laparoscopy-assisted ileocecal resection with lymph node dissection. The appendix had a diverticulum with chronic inflammation, but it did not have a neoplastic lesion. en-copyright= kn-copyright= en-aut-name=NinomiyaTakayuki en-aut-sei=Ninomiya en-aut-mei=Takayuki kn-aut-name=二宮卓之 kn-aut-sei=二宮 kn-aut-mei=卓之 aut-affil-num=1 ORCID= en-aut-name=OjimaYasutomo en-aut-sei=Ojima en-aut-mei=Yasutomo kn-aut-name=小島康知 kn-aut-sei=小島 kn-aut-mei=康知 aut-affil-num=2 ORCID= en-aut-name=HaranoMasao en-aut-sei=Harano en-aut-mei=Masao kn-aut-name=原野雅生 kn-aut-sei=原野 kn-aut-mei=雅生 aut-affil-num=3 ORCID= en-aut-name=OhnoSatoshi en-aut-sei=Ohno en-aut-mei=Satoshi kn-aut-name=大野聡 kn-aut-sei=大野 kn-aut-mei=聡 aut-affil-num=4 ORCID= en-aut-name=ShiozakiShigehiro en-aut-sei=Shiozaki en-aut-mei=Shigehiro kn-aut-name=塩崎滋弘 kn-aut-sei=塩崎 kn-aut-mei=滋弘 aut-affil-num=5 ORCID= en-aut-name=NinomiyaMotoki en-aut-sei=Ninomiya en-aut-mei=Motoki kn-aut-name=二宮基樹 kn-aut-sei=二宮 kn-aut-mei=基樹 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=2 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=3 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=4 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=5 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=6 en-affil= kn-affil=広島市立広島市民病院　外科 en-keyword=虫垂憩室症（appendiceal diverculum） kn-keyword=虫垂憩室症（appendiceal diverculum） en-keyword=腹腔鏡手術（laparoscopic surgery） kn-keyword=腹腔鏡手術（laparoscopic surgery） en-keyword=虫垂腫瘍（appendiceal tumor） kn-keyword=虫垂腫瘍（appendiceal tumor） END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=29 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=19950610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=小学校算数科における課題学習に通ずる教材の研究について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川陽子 kn-aut-sei=中川 kn-aut-mei=陽子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院教育学研究科 END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue=3 article-no= start-page=125 end-page=139 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fluctuation of water quality and growth characteristics of water hyacinth, Eichhornia crassipes (Mart.) Solms, in natural water area kn-title=自然水域における水質変動とホテイアオイEichhornia crassipes(Mart.) Solmsの生長特性 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AoyamaI. en-aut-sei=Aoyama en-aut-mei=I. kn-aut-name=青山勲 kn-aut-sei=青山 kn-aut-mei=勲 aut-affil-num=1 ORCID= en-aut-name=OkiY. en-aut-sei=Oki en-aut-mei=Y. kn-aut-name=沖陽子 kn-aut-sei=沖 kn-aut-mei=陽子 aut-affil-num=2 ORCID= en-aut-name=NishizakiH. en-aut-sei=Nishizaki en-aut-mei=H. kn-aut-name=西崎日佐夫 kn-aut-sei=西崎 kn-aut-mei=日佐夫 aut-affil-num=3 ORCID= en-aut-name=NakagawaK. en-aut-sei=Nakagawa en-aut-mei=K. kn-aut-name=中川恭二郎 kn-aut-sei=中川 kn-aut-mei=恭二郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= affil-num=4 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=高頻度のマイクロサテライト不安定性を伴った大腸癌におけるMLH1の特別な3’ プロモーターのメチル化あるいはBRAFの突然変異によるLynch症候群の効率的な分子学的検索 kn-title=Efficient molecular screening of Lynch syndrome by specific 3' promoter methylation of the MLH1 or BRAF mutation in colorectal cancer with high-frequency microsatellite instability en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaHitoshi en-aut-sei=Nakagawa en-aut-mei=Hitoshi kn-aut-name=中川仁志 kn-aut-sei=中川 kn-aut-mei=仁志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=1 article-no= start-page=49 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Preliminary Experiments on Sprouting of Hydrilla Vegetative Propagules. kn-title=沈水雑草クロモの繁殖器官の萌芽に関する予報 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ImanishiKiso en-aut-sei=Imanishi en-aut-mei=Kiso kn-aut-name=今西競 kn-aut-sei=今西 kn-aut-mei=競 aut-affil-num=1 ORCID= en-aut-name=OkiYoko en-aut-sei=Oki en-aut-mei=Yoko kn-aut-name=沖陽子 kn-aut-sei=沖 kn-aut-mei=陽子 aut-affil-num=2 ORCID= en-aut-name=NakagawaKyojiro en-aut-sei=Nakagawa en-aut-mei=Kyojiro kn-aut-name=中川恭二郎 kn-aut-sei=中川 kn-aut-mei=恭二郎 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=1 article-no= start-page=31 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Habitats and Morphological Variation of Three Submerged Aquatic Weeds, Egeria, Hydrilla and Elodea. kn-title=沈水雑草オオカナダモ,クロモ,コカナダモの生育環境及び外部形態の変異性に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkiYoko en-aut-sei=Oki en-aut-mei=Yoko kn-aut-name=沖陽子 kn-aut-sei=沖 kn-aut-mei=陽子 aut-affil-num=1 ORCID= en-aut-name=ImanishiKiso en-aut-sei=Imanishi en-aut-mei=Kiso kn-aut-name=今西競 kn-aut-sei=今西 kn-aut-mei=競 aut-affil-num=2 ORCID= en-aut-name=NakagawaKyojiro en-aut-sei=Nakagawa en-aut-mei=Kyojiro kn-aut-name=中川恭二郎 kn-aut-sei=中川 kn-aut-mei=恭二郎 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=1 article-no= start-page=5 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Burial Conditions on Seedling Emergence of Crabgrass (Digitaria adscendens Henrard) kn-title=メヒシバ種子の越冬時の埋土位置が畑地での出芽動態に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TsuyuzakiHiroshi en-aut-sei=Tsuyuzaki en-aut-mei=Hiroshi kn-aut-name=露崎浩 kn-aut-sei=露崎 kn-aut-mei=浩 aut-affil-num=1 ORCID= en-aut-name=NakagawaKyojiro en-aut-sei=Nakagawa en-aut-mei=Kyojiro kn-aut-name=中川恭二郎 kn-aut-sei=中川 kn-aut-mei=恭二郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=1 article-no= start-page=1 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Curriculum Vitae of Emeritus Professor Kyojiro NAKAGAWA kn-title=中川恭二郎博士略歴、中川恭二郎博士研究論文および著書目録 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大原農業研究所 kn-aut-sei=大原農業研究所 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue=2 article-no= start-page=51 end-page=78 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197909 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ecological studies on water nutsedge (Cyperus serotinus Rottb.) III. The intraspecific variations kn-title=ミズガヤツリの防除に関する生態学的研究 III. 種内変異について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaK. en-aut-sei=Nakagawa en-aut-mei=K. kn-aut-name=中川恭二郎 kn-aut-sei=中川 kn-aut-mei=恭二郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=4 article-no= start-page=195 end-page=215 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=197703 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ecological studies on water nutsedge (Cyperus serotinus Rottb.) II. The methods of cultural control kn-title=ミズガヤツリの防除に関する生態学的研究 II. 耕種的防除法について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaK. en-aut-sei=Nakagawa en-aut-mei=K. kn-aut-name=中川恭二郎 kn-aut-sei=中川 kn-aut-mei=恭二郎 aut-affil-num=1 ORCID= en-aut-name=HattoriK. en-aut-sei=Hattori en-aut-mei=K. kn-aut-name=服部金次郎 kn-aut-sei=服部 kn-aut-mei=金次郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=1 article-no= start-page=15 end-page=31 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=197702 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ecological studies on water nutsedge (Cyperus serotinus Rottb.) I. Individual ecological characteristics kn-title=ミズガヤツリの防除に関する生態学的研究 Ⅰ 個体生態について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaK. en-aut-sei=Nakagawa en-aut-mei=K. kn-aut-name=中川恭二郎 kn-aut-sei=中川 kn-aut-mei=恭二郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=2 article-no= start-page=67 end-page=77 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=197503 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The distribution of tall goldenrod (Solidago altissima L.) in Japan kn-title=セイタカアワダチソウ(Solidago altissima L.)の日本における分布 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaK. en-aut-sei=Nakagawa en-aut-mei=K. kn-aut-name=中川恭二郎 kn-aut-sei=中川 kn-aut-mei=恭二郎 aut-affil-num=1 ORCID= en-aut-name=EnomotoT. en-aut-sei=Enomoto en-aut-mei=T. kn-aut-name=榎本敬 kn-aut-sei=榎本 kn-aut-mei=敬 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=57 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lung cancer and molecular targeted drugs kn-title=肺癌と分子標的薬 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name=木浦勝行 kn-aut-sei=木浦 kn-aut-mei=勝行 aut-affil-num=1 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　呼吸器・アレルギー内科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 en-keyword=肺癌 kn-keyword=肺癌 en-keyword=分子プロファイリング kn-keyword=分子プロファイリング en-keyword=分子標的薬 kn-keyword=分子標的薬 en-keyword=EGFR遺伝子変異 kn-keyword=EGFR遺伝子変異 en-keyword=ALK融合遺伝子 kn-keyword=ALK融合遺伝子 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An epidemiologically rare case of Vibrio vulnificus infection that occurred in October in an inland city of Japan kn-title=内陸地津山で発症した季節外れのVibrio vulnificus感染症 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 68-year-old man with alcohol addiction, who lived in the suburbs of Tsuyama, an inland city located in northeast Okayama prefecture, was transported to the emergency unit of the Tsuyama Central Hospital in a state of cardiopulmonary arrest (CPA). Despite rigorous systemic investigation and treatment, the patient died 2 hours after arrival. After his death, Vibrio vulnificus was isolated from his blood culture. 　Vibrio vulnificus causes fatal infection in humans, usually only in areas located close to the sea where appropriate temperature and suitable salt concentration for its growth are available. Therefore, its occurrence is epidemiologically restricted ; in Japan, the western coastal areas, especially in summers, are reported to be the high-risk regions. This is a rare case because it occurred in a city approximately 50 kilometers from both the Sea of Japan and the Pacific coast of Okayama, and at the end of October in 2011. Economic development and distribution systems have made it possible to transport various food products from coastal areas or abroad to any place in a short time, such that these infections can potentially develop in areas other than expected. We should be aware of the increasing risk of Vibrio vulnificus infection during any season and at any place, especially in patients with abnormal liver function. en-copyright= kn-copyright= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name=萩谷英大 kn-aut-sei=萩谷 kn-aut-mei=英大 aut-affil-num=1 ORCID= en-aut-name=ShiotaSumiko en-aut-sei=Shiota en-aut-mei=Sumiko kn-aut-name=塩田澄子 kn-aut-sei=塩田 kn-aut-mei=澄子 aut-affil-num=2 ORCID= en-aut-name=MiyoshiShin-ichi en-aut-sei=Miyoshi en-aut-mei=Shin-ichi kn-aut-name=三好伸一 kn-aut-sei=三好 kn-aut-mei=伸一 aut-affil-num=3 ORCID= en-aut-name=KuroeYasutoshi en-aut-sei=Kuroe en-aut-mei=Yasutoshi kn-aut-name=黒江泰利 kn-aut-sei=黒江 kn-aut-mei=泰利 aut-affil-num=4 ORCID= en-aut-name=NojimaHiroyoshi en-aut-sei=Nojima en-aut-mei=Hiroyoshi kn-aut-name=野島宏悦 kn-aut-sei=野島 kn-aut-mei=宏悦 aut-affil-num=5 ORCID= en-aut-name=OtaniShinkichi en-aut-sei=Otani en-aut-mei=Shinkichi kn-aut-name=大谷晋吉 kn-aut-sei=大谷 kn-aut-mei=晋吉 aut-affil-num=6 ORCID= en-aut-name=SugiyamaJunichi en-aut-sei=Sugiyama en-aut-mei=Junichi kn-aut-name=杉山淳一 kn-aut-sei=杉山 kn-aut-mei=淳一 aut-affil-num=7 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name=内藤宏道 kn-aut-sei=内藤 kn-aut-mei=宏道 aut-affil-num=8 ORCID= en-aut-name=KawanishiSusumu en-aut-sei=Kawanishi en-aut-mei=Susumu kn-aut-name=川西進 kn-aut-sei=川西 kn-aut-mei=進 aut-affil-num=9 ORCID= en-aut-name=HagiokaShingo en-aut-sei=Hagioka en-aut-mei=Shingo kn-aut-name=萩岡信吾 kn-aut-sei=萩岡 kn-aut-mei=信吾 aut-affil-num=10 ORCID= en-aut-name=MorimotoNaoki en-aut-sei=Morimoto en-aut-mei=Naoki kn-aut-name=森本直樹 kn-aut-sei=森本 kn-aut-mei=直樹 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=2 en-affil= kn-affil=就実大学薬学部　病原微生物学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　衛生微生物化学 affil-num=4 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=5 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=6 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=7 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=8 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=9 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=10 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=11 en-affil= kn-affil=津山中央病院　救命救急センター en-keyword=Vibrio vulnificus kn-keyword=Vibrio vulnificus END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=3 article-no= start-page=243 end-page=247 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20121203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of intracystic carcinoma of the breast showing pathological complete response by neoadjuvant chemotherapy kn-title=術前化学療法により壁が菲薄化し組織学的寛解（pCR）となった巨大嚢胞内乳癌の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 31-year-old woman presented to our hospital because of a lump 5cm in diameter in her right breast. Ultrasonography revealed a multilocular cystic mass with partial thickening of the wall and the septum. Core needle biopsy (CNB) of the septum confirmed invasive ductal carcinoma. The patient was administered neoadjuvant chemotherapy consisting of 12 cycles of weekly paclitaxel followed by 4 cycles of FEC (5FU, Epilubicin and cyclophosphamide). While the thickness of the wall and septum became thinner, the tumor size did not change in diameter. She underwent right mastectomy and sentinel node biopsy. Post-surgical histopathological findings showed a pathological complete response (pCR).
　We report a rare case of invasive ductal carcinoma presenting a multilobular phenotype which showed pCR by neoadjuvant chemotherapy despite no size reduction of the tumor. en-copyright= kn-copyright= en-aut-name=ImadaTakako en-aut-sei=Imada en-aut-mei=Takako kn-aut-name=今田孝子 kn-aut-sei=今田 kn-aut-mei=孝子 aut-affil-num=1 ORCID= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=2 ORCID= en-aut-name=MotokiTakayuki en-aut-sei=Motoki en-aut-mei=Takayuki kn-aut-name=元木崇之 kn-aut-sei=元木 kn-aut-mei=崇之 aut-affil-num=3 ORCID= en-aut-name=IwamotoTakayuki en-aut-sei=Iwamoto en-aut-mei=Takayuki kn-aut-name=岩本高行 kn-aut-sei=岩本 kn-aut-mei=高行 aut-affil-num=4 ORCID= en-aut-name=OomoriMasako en-aut-sei=Oomori en-aut-mei=Masako kn-aut-name=大森昌子 kn-aut-sei=大森 kn-aut-mei=昌子 aut-affil-num=5 ORCID= en-aut-name=IhaSigemichi en-aut-sei=Iha en-aut-mei=Sigemichi kn-aut-name=伊波茂道 kn-aut-sei=伊波 kn-aut-mei=茂道 aut-affil-num=6 ORCID= en-aut-name=HongoToshie en-aut-sei=Hongo en-aut-mei=Toshie kn-aut-name=本後登志江 kn-aut-sei=本後 kn-aut-mei=登志江 aut-affil-num=7 ORCID= en-aut-name=HenmiNoriko en-aut-sei=Henmi en-aut-mei=Noriko kn-aut-name=逸見典子 kn-aut-sei=逸見 kn-aut-mei=典子 aut-affil-num=8 ORCID= en-aut-name=MakabeMikio en-aut-sei=Makabe en-aut-mei=Mikio kn-aut-name=真壁幹夫 kn-aut-sei=真壁 kn-aut-mei=幹夫 aut-affil-num=9 ORCID= en-aut-name=NogamiHiromi en-aut-sei=Nogami en-aut-mei=Hiromi kn-aut-name=野上浩實 kn-aut-sei=野上 kn-aut-mei=浩實 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=5 en-affil= kn-affil=岡山大学病院　病理診断科 affil-num=6 en-affil= kn-affil=岡山大福クリニック affil-num=7 en-affil= kn-affil=岡山大福クリニック affil-num=8 en-affil= kn-affil=岡山大福クリニック affil-num=9 en-affil= kn-affil=岡山中央病院 affil-num=10 en-affil= kn-affil=野上病院 en-keyword=嚢胞内乳癌（intracystic breast cancer） kn-keyword=嚢胞内乳癌（intracystic breast cancer） en-keyword=術前化学療法（neoadjuvant chemotherapy） kn-keyword=術前化学療法（neoadjuvant chemotherapy） en-keyword=組織学的完全奏功（pahthological CR） kn-keyword=組織学的完全奏功（pahthological CR） END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=4 article-no= start-page=241 end-page=251 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080425 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Basic Study on Activation of Antioxidation Function in Some Organs of Mice by Radon Inhalation Using New Radon Exposure Device kn-title=ラドン吸入試作装置によるマウス諸臓器中の抗酸化機能の亢進に関する研究 en-subtitle= kn-subtitle= en-abstract=There are a lot of life style diseases that are related to reactive oxygen species in indications of the radon therapy, and, the further clarification of mechanism is expected. Therefore, in this study, we investigated the activation of antioxidation function in some organs of mice by radon inhalation using the new radon exposure device. It was enable that this device was the adjustments of radon concentration by changing the air flow rate to the specially processed radon source and so on. The mice were made to inhale the radon of 400Bq/m3 or 4000Bq/m3 with this device. Results show that in brain, lungs, liver, and kidney, both the activities of superoxide dismutase(SOD) and catalase increased, and lipid peroxide levels decreased. This suggests that radon inhalation enhanced the antioxidation function. These findings are important in understanding the mechanism of diseases in which radon therapy is used as treatment, and most of which are called activated oxygen-related diseases. kn-abstract=ラドン療法の適応症には活性酸素に由来する生活習慣病が多く，その機構の更なる解明が期待されている。また，汎用性があり医学的効果が再現できるラドン吸入装置の構築は意義が大きい。このため，著者らは共同で開発したラドン吸入試作装置を用い，マウス諸臓器中の抗酸化機能の変化特性を検討した。ラドン吸入試作装置は，特殊加工したラドン線源を収納したユニットの数量，それへの送風量及び湿度などを調節することによりラドン濃度を自在に調整可能にするものである。この装置によりマウスに400Bq/m3あるいは4000Bq/m3のラドンを吸入させた。その結果，脳・肺・肝臓・腎臓において，抗酸化系酵素であるSODとカタラーゼの両活性が増加し，過酸化脂質量が減少した。この抗酸化機能の亢進により，本実験条件でのラドン吸入は活性酸素障害の抑制，すなわち，生活習慣病の予防や症状緩和に効果のある可能性が改めて示唆できた。 en-copyright= kn-copyright= en-aut-name=NakagawaShinya en-aut-sei=Nakagawa en-aut-mei=Shinya kn-aut-name=中川慎也 kn-aut-sei=中川 kn-aut-mei=慎也 aut-affil-num=1 ORCID= en-aut-name=KataokaTakahiro en-aut-sei=Kataoka en-aut-mei=Takahiro kn-aut-name=片岡隆浩 kn-aut-sei=片岡 kn-aut-mei=隆浩 aut-affil-num=2 ORCID= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name=迫田晃弘 kn-aut-sei=迫田 kn-aut-mei=晃弘 aut-affil-num=3 ORCID= en-aut-name=IshimoriYuu en-aut-sei=Ishimori en-aut-mei=Yuu kn-aut-name=石森有 kn-aut-sei=石森 kn-aut-mei=有 aut-affil-num=4 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name=花元克巳 kn-aut-sei=花元 kn-aut-mei=克巳 aut-affil-num=5 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name=山岡聖典 kn-aut-sei=山岡 kn-aut-mei=聖典 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=3 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=4 en-affil= kn-affil=独立行政法人　日本原子力研究開発機構人形峠環境技術センター affil-num=5 en-affil= kn-affil=岡山大学大学院保健学研究科 affil-num=6 en-affil= kn-affil=岡山大学大学院保健学研究科 en-keyword=new radon exposure device kn-keyword=new radon exposure device en-keyword=radon inhalation kn-keyword=radon inhalation en-keyword=antioxidative function kn-keyword=antioxidative function en-keyword=superoxide dismutase kn-keyword=superoxide dismutase en-keyword=catalase kn-keyword=catalase en-keyword=lipid peroxide kn-keyword=lipid peroxide en-keyword=active oxygen kn-keyword=active oxygen en-keyword=mouse kn-keyword=mouse en-keyword=radon-222 kn-keyword=radon-222 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=2 article-no= start-page=149 end-page=153 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of strangulated ileus caused by transomental hernia with reference to previously reported cases kn-title=術前診断し得た大網裂孔ヘルニアの一例―本邦報告203例の臨床病理学的検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Transomental hernia often develops into strangulated ileus. We report on an 81-year-old man with strangulated ileus due to transomental hernia, diagnosed preoperatively by abdominal CT. The patient was referred to our surgical division because of progressive abdominal pain and vomiting. He had no history of laparotomy. An abdominal CT scan showed dilated small intestinal loops with intraluminal air and strangulated small intestinal loops with engorged mesenteric vessels. We diagnosed this as a strangulated internal hernia due to transomental hernia and conducted an emergency laparotomy. The jejunum had herniated through an abnormal hiatus of the greater omentum to the peritoneal cavity. The strangulated intestinal loop, about 15 cm long, was released and the postoperative course was uneventful. In the absence of a previous laparotomy, the differential diagnosis of intestinal obstruction should include internal hernia. An abdominal CT scan is useful for the preoperative and prompt diagnosis of transomental hernia. en-copyright= kn-copyright= en-aut-name=KimuraYuji en-aut-sei=Kimura en-aut-mei=Yuji kn-aut-name=木村裕司 kn-aut-sei=木村 kn-aut-mei=裕司 aut-affil-num=1 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=岩川和秀 kn-aut-sei=岩川 kn-aut-mei=和秀 aut-affil-num=2 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=3 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=4 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　外科 en-keyword=大網裂孔ヘルニア（transomental hernia） kn-keyword=大網裂孔ヘルニア（transomental hernia） en-keyword=絞扼性イレウス（strangulated ileus） kn-keyword=絞扼性イレウス（strangulated ileus） END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue= article-no= start-page=59 end-page=62 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201204 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Usefulness of ICR mice as genetic resources kn-title=ICRマウスの遺伝子資源としての有用性 en-subtitle= kn-subtitle= en-abstract= kn-abstract=ICR(Yok:ICR)mice were introduced into the National Instltute of Infectious Diseases in 1965,and have been bred and produced there.Two inbred mutant mouse strains,MPS and ICGN,were created using(originated from)Yok:ICR mice in 1986.The MPS and ICGN mouse strains have served as the animal disease models of mycoplasma infectious disease and congenital nephritic syndrome,respectively. Genetic variations were detected by the genetic monitoring of Yok:ICR mice using biochemical markers.However, no difference was detected in gene expression profiles between the MPS and ICGN mouse strains.ICR mice may harbor genes that are spontaneously mutated,thereby allowing the creation of new pathological models through the segregation and/or selection(screening)of mutant genes. en-copyright= kn-copyright= en-aut-name=YamamotoYoshie en-aut-sei=Yamamoto en-aut-mei=Yoshie kn-aut-name=山本美江 kn-aut-sei=山本 kn-aut-mei=美江 aut-affil-num=1 ORCID= en-aut-name=Uchio-YamadaKozue en-aut-sei=Uchio-Yamada en-aut-mei=Kozue kn-aut-name=内尾-山田こずえ kn-aut-sei=内尾-山田 kn-aut-mei=こずえ aut-affil-num=2 ORCID= en-aut-name=TakanoKaoru en-aut-sei=Takano en-aut-mei=Kaoru kn-aut-name=高野薫 kn-aut-sei=高野 kn-aut-mei=薫 aut-affil-num=3 ORCID= en-aut-name=OguraAtsuo en-aut-sei=Ogura en-aut-mei=Atsuo kn-aut-name=小倉淳郎 kn-aut-sei=小倉 kn-aut-mei=淳郎 aut-affil-num=4 ORCID= en-aut-name=AsanoToshihiko en-aut-sei=Asano en-aut-mei=Toshihiko kn-aut-name=浅野敏彦 kn-aut-sei=浅野 kn-aut-mei=敏彦 aut-affil-num=5 ORCID= en-aut-name=NakagawaMasarou en-aut-sei=Nakagawa en-aut-mei=Masarou kn-aut-name=中川雅郎 kn-aut-sei=中川 kn-aut-mei=雅郎 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=国立感染症研究所 affil-num=2 en-affil= kn-affil=医薬基盤研究所 affil-num=3 en-affil= kn-affil=医薬基盤研究所 affil-num=4 en-affil= kn-affil=理化学研究所 affil-num=5 en-affil= kn-affil=国立感染症研究所 affil-num=6 en-affil= kn-affil=国立感染症研究所 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=1 article-no= start-page=63 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pathological complete response of advanced gastric cancer with pyloric stenosis to neoadjuvant S-1/CDDP chemotherapy: A case report kn-title=S-1/CDDP術前化学療法により組織学的CRが得られた幽門狭窄合併進行胃癌の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 59-year-old man with epigastric discomfort and anorexia was referred to our hospital. Endoscopy revealed a type 3 advanced gastric cancer with pyloric stenosis diagnosed as a poorly differentiated adenocarcinoma in the biopsy specimens. A gastrojejunal bypass operation was performed because of direct invasion to the pancreas. The patient was treated by three courses of neoadjuvant chemotherapy with S-1/CDDP. Follow-up abdominal CT scan revealed that the primary tumor had become smaller, suggesting that a partial response had been achieved. Distal gastrectomy with D2 lymphadenectomy was performed. The histopathological examination showed no residual cancer cells in the primary lesion or dissected lymph nodes. Final chemotherapy efficacy was evaluated as Grade 3. The patient was treated with S-1 for one year after the gastrectomy and lymphadenectomy and has been followed up for 18 months without evidence of recurrence. en-copyright= kn-copyright= en-aut-name=NishizakiMasahiko en-aut-sei=Nishizaki en-aut-mei=Masahiko kn-aut-name=西崎正彦 kn-aut-sei=西崎 kn-aut-mei=正彦 aut-affil-num=1 ORCID= en-aut-name=FujiwaraYasuhiro en-aut-sei=Fujiwara en-aut-mei=Yasuhiro kn-aut-name=藤原康宏 kn-aut-sei=藤原 kn-aut-mei=康宏 aut-affil-num=2 ORCID= en-aut-name=ChoudaYasuhiro en-aut-sei=Chouda en-aut-mei=Yasuhiro kn-aut-name=丁田泰宏 kn-aut-sei=丁田 kn-aut-mei=泰宏 aut-affil-num=3 ORCID= en-aut-name=KanazawaTakashi en-aut-sei=Kanazawa en-aut-mei=Takashi kn-aut-name=金澤卓 kn-aut-sei=金澤 kn-aut-mei=卓 aut-affil-num=4 ORCID= en-aut-name=NinomiyaMotoki en-aut-sei=Ninomiya en-aut-mei=Motoki kn-aut-name=二宮基樹 kn-aut-sei=二宮 kn-aut-mei=基樹 aut-affil-num=5 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 affil-num=2 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=3 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=4 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=5 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学 en-keyword=幽門狭窄 (pyloric stenosis) kn-keyword=幽門狭窄 (pyloric stenosis) en-keyword=進行胃癌 (advanced gastric cancer) kn-keyword=進行胃癌 (advanced gastric cancer) en-keyword=S-1/CDDP kn-keyword=S-1/CDDP en-keyword=術前化学療法 (neoadjuvant chemotherapy) kn-keyword=術前化学療法 (neoadjuvant chemotherapy) en-keyword=組織学的CR (pathological CR) kn-keyword=組織学的CR (pathological CR) END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=383 article-no= start-page=853 end-page=855 dt-received= dt-revised= dt-accepted= dt-pub-year=1921 dt-pub=19211231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=惡性脈絡膜上皮腫ノ急速轉移ノ一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川武雄 kn-aut-sei=中川 kn-aut-mei=武雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫學専門學校産婦人科 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=373 article-no= start-page=127 end-page=158 dt-received= dt-revised= dt-accepted= dt-pub-year=1921 dt-pub=19210228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=バーンス氏「ソリウム」液ニ依ル「ピエログラフィー」ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川小四郎 kn-aut-sei=中川 kn-aut-mei=小四郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=村松篤治 kn-aut-sei=村松 kn-aut-mei=篤治 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫學専門學校皮花泌尿科及「レントゲン」科 affil-num=2 en-affil= kn-affil=岡山醫學専門學校皮花泌尿科及「レントゲン」科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ニフェカラント抵抗性不整脈に対する静注アミオダロン投与について―重症心不全患者連続11例での検討― kn-title=Use of Intravenous Amiodarone in the Treatment of Nifekalant-Resistant Arrhythmia : A Review of 11 Consecutive Cases with Severe Heart Failure en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaKoji en-aut-sei=Nakagawa en-aut-mei=Koji kn-aut-name=中川晃志 kn-aut-sei=中川 kn-aut-mei=晃志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=129 end-page=132 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laparoscopic surgery for mesenteric Castleman's disease kn-title=腹腔鏡下に摘出しえた上行結腸間膜発生のCastleman病の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report herein a case of mesenteric Castleman's disease which was confirmed on pathology. A 60-year-old man was admitted to our hospital complaining of abdominal pain. On the physical examination, there was no palpable mass. Computed tomography findings and magnetic resonance imaging revealed a well circumscribed, lobulated round mass on the right side of the superior mesenteric vein. Laparoscopic surgery for the mesenteric tumor was carried out to obtain a definite diagnosis and treatment. In the operative field, the mass was located on the ascending colic mesentery and measured about 3 cm in size. It was solid and surrounded by a thin fibrous capsule. The histological diagnosis of the mesenteric tumor was hyaline vascular type Castleman's disease. The postoperative course of the patient was uneventful, and he was discharged on the 10th postoperative day. en-copyright= kn-copyright= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=1 ORCID= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=大塚真哉 kn-aut-sei=大塚 kn-aut-mei=真哉 aut-affil-num=2 ORCID= en-aut-name=TomodaJun en-aut-sei=Tomoda en-aut-mei=Jun kn-aut-name=友田純 kn-aut-sei=友田 kn-aut-mei=純 aut-affil-num=3 ORCID= en-aut-name=FujiwaraKeishi en-aut-sei=Fujiwara en-aut-mei=Keishi kn-aut-name=藤原敬士 kn-aut-sei=藤原 kn-aut-mei=敬士 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　内科 affil-num=4 en-affil= kn-affil=光生病院　内科 en-keyword=結腸間膜 (mesocolon) kn-keyword=結腸間膜 (mesocolon) en-keyword=Castleman病 (Castleman's disease) kn-keyword=Castleman病 (Castleman's disease) en-keyword=腹腔鏡手術 (laparoscopic surgery) kn-keyword=腹腔鏡手術 (laparoscopic surgery) END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=6 article-no= start-page=1193 end-page=1205 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19410630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Über die Wirkung der reinen Lipage auf Blutbefunde kn-title=「リパーゼ」ノ血液所見ニ及ボス影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nach dem Yerfahren von Willstätter und Waldschmidt-Leitz hat der Verf. aus dem Pankreas von Schweinen Lipaselösung hergestellt, indem er zunächst das Pankreas durch Anwendung von Azeton und Äther getrocknet, durch Glyzerin extrahiert, nach Ansätuerung die Lipase an Tonerde-B adsorbieren liess und schliesslich mittels einer Lösung von Ammonphosphatglyzerin extrahiert hatte. Die auf diese Weise erhaltene Lipaselösung hat er sodann den Versuchskaninchen intravenös eingeführt, um die Zahl der Leukozyten, Erythrozyten und Blutplättchen, Blutsenkungsgeschwindigkeit, Blutungs-und gerinnungszeit festzugtellen.Als Kontrolle dienten die Kaninchen, denen die Lösung von Ammonphosphatglyzerin intravenös eingeführt worden war. Ausserdem hat der Verf. anderen Kaninchen vegetative Rizinuslipase intrapelitoneal injiziert und gleiche Bestimmungen vorgenommen. Aus diesen Versuchen erhielt der Verf.folgende Ergebnisse: 1) Die Leukozyten scheinen quantitativ zuzunehmen. 2) Die Erythrozyten nehmen im allgemeinen an Mengeg ab, ab, aber nach intraperitonealer Einführungmng der Rizinuslipase tritt bei ihnen vielmehr Vermehrung ein. 3) Die Senkungsgeschwindigkeit der Erythrozyten wird zwar beschleunigt, aber in nur versch windend geringem Masse. 4) Blutungs- und Gerinnungszeit wird ohne allen Zweifel velängertb. 5) Die Blutplättchen nehmen auch an Zahl ab. en-copyright= kn-copyright= en-aut-name=NakagawaYoshio en-aut-sei=Nakagawa en-aut-mei=Yoshio kn-aut-name=中川美雄 kn-aut-sei=中川 kn-aut-mei=美雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=6 article-no= start-page=1179 end-page=1192 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19410630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Untersuchungen der Lipase und der Toxizitat des Pankreas bei der experimentell hervorgerufenen akuten Pankreasnekrose (VI. Mitteilung). Über die Giftigkeit des Pankreas bei experimcntell hervorgerufener akuter Pankreasnekrose kn-title=實驗的急性膵臓壞死時ニ於ケル「リパーゼ」竝ニ毒性ニ關スル研究（第4編）實驗的急性膵臓壞死時ニ於ケル膵臓ノ毒性ニ關スル研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Es ist bereits von vielen Autoren festgestellt worden, dass bei tödlicher Nekrose der Bauchspeicheldrüse die Spaltungsprodukte von Eiweiss eine wichtige Rolle spielen. Um diese Verhältnisse noch häher zu erörtern, hat der Verf. 50%ige Emulsion von Hundpankreas in die Schwanzvenen von Mäusen eingeführt und fand, dass zwischen dem normalen und dem nekrotischen Pankreas an Toxizität kein erheblicher Unterschied vorhanden war. Beim Kochen der Emulsion auf 10'-30' aber gingen die Fermente des Pankreas fast vollstandig verloren und es ergab sich, dass in diesen Fall das durch Einführung von Olivenöl nekrotisierte Pankreas die stärkste Giftigkeit hervorbrachte. Als er ferner gesundes und nekrotisiertes Pankreas von Hunden nach Goodpasture und Clark auf autolytischem Wege verflüssigte und sodann das angesäuerte Filtrat durch Hinzufügung von Eisessig zum Fall brachte, konnte er zwischen den beiden Niederschlägen keinen grossen Unterschied an Giftigkeit feststellen. Das Kommt nach dem Erachten des Verf.s daher, dass beim gesunden Pankreas durch Autolyse giftige Substanzen in reichlicher Menge entstehen. Wenn man aber das Pankreas ohne Ausführung der Autolyse emulgierte und das sauer reagierende Filtrat sofort durch Eisessig zum Fall brachte, ergab sich, dass das in stärkerem Masse nekrotisierte Pankreas viel beträchtlichere Giftigkeit aufwies als das nicht so stark krankhaft veränderte Pankreas. Um den Einfluss der Autolyse auf die Giftigkeit festzustellen, liess der Verf. das Pankreas nach der Einfübrung von Galle, Ölusw. 24-48 Stunden lang der Autolyse verfallen. Daraus stellte sich heraus, dass die Giftigkeit um so stärker auftrat, je länger das Pankreas auf der Autolyse verlassen worden waren. Um schliesslich das Wesen dieser giftigen Substanzen festzustellen, hat der Verf. bei der Pankreasemulsion die Phosphorwolframsäure-Isolierung durchgeführt und fand, dass der basische Rückstand viel stärkere Giftigkeit aufwies als das saure Filtrat. en-copyright= kn-copyright= en-aut-name=NakagawaYoshio en-aut-sei=Nakagawa en-aut-mei=Yoshio kn-aut-name=中川美雄 kn-aut-sei=中川 kn-aut-mei=美雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=5 article-no= start-page=1147 end-page=1158 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19410531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ein Fall von traumatischer Pankreasnekrose kn-title=外傷性膵臟壊死ノ1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) Der Verf. konnte bei einem 33 jährigen Mann, der infolge von stumpfer Gewalteinwirkung auf den Oberbauch akute Pankreasnekrose erlitt, bald nach dem Auftritt diesen Krankheit (1 Stunde 50 Minuten später) die Operation ausführen und den Kranken zur Heilung bringen. 2) Es handelte sich um eine ausgedehnte Blutung am Kopf- und Körperteile des Pankreas ohne Schädigungen anderer Organe der Bäuchhöhle. Gesunder Herd wurde nur am Schwanzteil des Pankreas beobachtet, 3) Der Kranke wurde nüchtern verwundet, was die Annahme nahe legte, dass sich das Pankreas, vom topographisch-anatomischen Standpunkt aus betrachtet, in einer leicht zu verletzenden l. age befand. An Hand von Statistiken weist der Verf. darauf hin, dass bei jugendlichen Personen die Verletzung des Pankreas auch nach Mahlzeit leicht zustande kommt. 4) Allgemeines Symptom bestand in traumatischer Schock. Als lokale Symptome zeigte der Oberbauch grosse Schmerzhaftigkeit gegen die r-Oberbauchgegend hin. Der Muskel dieser Gegend befand sich im Zustand der sog. Défense musculaire. Vor der Operation wurden eine Vermehrung der weissen Zellen sowie eine leichtgradige Linksverschiebung und eine Verringerung der roten Zellen beobachtet. Die Menge der Harndiastase war normal, wahread die der Serum-Diastase eine kleine Vermehrung aufwies, 5) Bei der Operation wurde das Exsudat der Pankreasgegend durch eine Drainage, welche durch das Lig. gastrocolica hindurchgezogen wurde, auf das möglichste ausgeschieden. Das Exsudat das sich vom Foramen Winslowi her in der Umgebung der Gallenblase stagnierte, wurde durch Anlegung einer Drainage an dieser Gegend abgelassen. 6) Der Verf. sammelte sodann in der japanischen Literatur I8 Fälle der subkutanen Schädigung des Pankreas, an denen er stätistische Beobachtung angestellt hat. Daraus stellte sich heraus, dass die Schädigung meistens durch Stoss Von Holz und Stein, durch Hufschlag, Eingeklemmtwerden zwischen den Pufferapparaten usw. verursacht wurde. Das Alter der Patienten lag zwischen 6 und 40 Jahren. Die Krankheit kamen fast ausschliesslich bei Männern vor. Nach Art der Verletzungen nimmt unvollständige Zerreissung die erste Stelle ein, ihr folgen dann Blutung, Vollständige Zerreissung, Quetschung und Quetschungsnekrose. Bezüglich des Ausgangs der Krankheit ergibt sich, dass von den 18 Fallen 13 Fälle zur Heilung kamen, 4 Fälle tödlich ausgingen and 1 Fall unklar war. en-copyright= kn-copyright= en-aut-name=NakagawaYoshio en-aut-sei=Nakagawa en-aut-mei=Yoshio kn-aut-name=中川美雄 kn-aut-sei=中川 kn-aut-mei=美雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=5 article-no= start-page=1074 end-page=1080 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19410531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Untersuchungen der Lipase und der Toxizität des Pankreas bei der experimentell hervorgerufenen akuten Pankreasnekrose (III. Mitteilung). Über die Menge der Fettsäuren im nekrotischen Pankreas bei experimentell hervorgerufener akuter Pankreasnekrose kn-title=實驗的急性膵臟壊死時ニ於ケル「リパーゼ」竝ニ毒性ニ關スル研究（第3編）實驗的急性膵臟壊死時ニ於ケル壊死膵臟中ノ脂肪酸量ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Es ist schon längst allgemein anerkannt, dass bei akuter Pankreasnekrose die Fette durch Einwirkung von Lipasen in Fettsäuren und Glyzerin abgebaut werden, und dass die Fettsäuren dann mit dem im Blut enthaltenen Kalzium in Verbindung treten, wodurch toxische Seifen entstehen, die das Pankreasgewebe zur Nekrose führen. Der Verf. hat bei Versuchshunden durch Einfubräng von Galle und Olivenöl oder durch Unterbindung der Arterien des Pankreas usw. akute Paekreasnekrose hervorgerufen. Als er nach dem Tode der Hunden durch Anwepdung der Modifikation der Methode von Bloor, Pelkan und Allen die Menge der Fettsöueren im Pankreas bestimmt hatte, ergab sich, dass die Fettsöuren des Pankreas bei nekrotjsierten Partien am starksten zunahmen, weniger stark bei Blutungspartien. Bei Ödematösen Partien wurde bisweilen beobachtet, dass die Fettsäuren eine stärkere Verminderung als bei der noch gesund gebliebenen Partien zeigten. Das kommt wohl nach dem Erachten des Verf. s daher, dass diese ödematösen Partien reichlich Wasser enthielten. Eine besonders starke Vermehrnng der Fettsäuren nach Einfuhrung von Olivenöl findet ihre Erklärung in der Spaltung des Olivenöls. In einem klinischen Fall von akuter Pankreasnekrose konnte der Verf. in dem bei der Sektion herausgenommenen Pankreas eine beträchtliohe Vermehung der Festsäuren feststellen. en-copyright= kn-copyright= en-aut-name=NakagawaYoshio en-aut-sei=Nakagawa en-aut-mei=Yoshio kn-aut-name=中川美雄 kn-aut-sei=中川 kn-aut-mei=美雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=5 article-no= start-page=1063 end-page=1074 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19410531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Unterauchungen der Lipase und der Toxizitat des Pankreae bei der experimentell hervorgerufenen akuten Pankreasnekrose (II. Mitteilung) Über die Menge der Lipase in der Lunge, Leber, Milz, den Nieren und dem Pankreas bei experimentell hervorgerufener akuter Pankreasnekrose kn-title=實驗的急性膵臓壊死時ニ於ケル「リパーゼ」竝ニ毒性ニ關スル研究（第2編）實驗的急性膵臓壊死時ニ於ケル肺肝脾腎膵臓中ノ「リペーゼ」量ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Um die quantitative Verteilung der Lipase in den wichtigeren Organen des Körpersbei akuter Pankreasnekrose featzustellen, hat der Verf. bei Versuchshunden akute Pankreasnekrose experimentell hervorgerufen und nach dem Tode bzw. nach kunstlicher Tötung der Hunde die Lunge, Leber, Milz und die Nieren aus ihnen herausgenommen. Als er sodann diese Organe in 50% ige. Emulsion verwandelt und die Menge der Lipase durch Anwendung der Imokawaschen Methode bestimmt hatte, fand er, dass die Menge derLipase in jedem Organ mit den Veranderungen des Pankreas in einer bestimmten Bezie-hung stand. Es ergab sich namlich, dass, wenn die Krankheitsveränderung nur in leichterem Grade auftrat, die Lipase in den einzelnen genannten Organen im Frühstadium der Krankheit keine Vermehrung aufwies, und das die Vermehrung erst nach 50-80 Stundenzur Beobachtung kam. Wenn aber die Veranderungen ziemlich stark eintraten, nahm die Lipase im Gegensatz zum leichten Fall vor dem Ablauf von 20-30 Stunden an Menge ab, um sich danach nicht nur nicht zu vermehren, sondern sich im allgemeinen vielmehr zu vermindern. Wenn ferner die Veranderung im hochsten Grade auftrat, d.h. bei der hochgradigen Nekrose, zeigte die Lipase in jedem Organ fast keine Vermehrung mehr. Aus der Erwägung über die Stärke der Veranderungen und die Menge der Lipase im Pankreas geht hervor, dass es, obwohl sich das Pankreas bei leichterer Veranderung in ziemlich lebhafter Tätigkeit befindet, sehr lang dauert, bis die Lipase in die Blutbahn geNangt und weiterhin in die einzelnen Organe eintritt da die Lipase nur schwer absorbiert werden kann. Daher kommt es, dass die Vermehrung der Lipase bei leichteier Krankheitsform nicht im Frühstadium, sondern erst im Spätstadium eintritt, und zwar in gerin-gem Masse. Wenn die krankhafte Veränderung in ziemlich starkem Masse auftritt, ge- langt die Lipase yerhältnismassig schnell in die einzelnen Organe, da die Pankreasfunktion dem Grad der Veränderungen entsprechend gesteigert wird. Was die Verringerung der Lipase im Spätstadium angeht, so liegt die Annahme nahe, dass die Lipase vom Pankreas nicht mehr abgesondert wird, da das Pankreas schliesslich zerstört wird und ihm die Funktionen verloren gehen. Wenn die Krankheitsveranderung den höchsten Grad erreicht, so wird die Lipase im vollständig zerstörten Pankreas gar nicht erzeugt, was ihren Übergang in die Blutbahn und auch ihre Vermehrung in den Organen unmöglich machen muss. Die Lipase wurde in den Nieren am reichlichsten angetroffen, weniger reichlich in der Leber und Milz, am wenigsten in der Lunge. en-copyright= kn-copyright= en-aut-name=NakagawaYoshio en-aut-sei=Nakagawa en-aut-mei=Yoshio kn-aut-name=中川美雄 kn-aut-sei=中川 kn-aut-mei=美雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=5 article-no= start-page=1039 end-page=1062 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19410531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Uutersuchungen der Lipase und der ToxizitAus der Chirurgischen Klinik der Medizinischen Fakultät Okayamat des Pankreas bei der experimentell hervorgerufenenakuten Pankreasnekrose (I. Mitteilung.) Über die quantitativen Schwankungen der Lipase im Blutserum und im Bauchexsudat bei experimentell hervorgerufener akuter Pankreasnekrose) kn-title=實驗的急性膵臓壞死時ニ於ケル「リパーゼ」竝ニ毒性ニ關スル研究（第1編)實驗的急性膵臓壞死時ニ於ケル血清及ビ腹腔浸出液中「リパーゼ」ノ消長ニ就テ） en-subtitle= kn-subtitle= en-abstract= kn-abstract=Was das quantitative Verhalten der Lipase im Blutserum bei akuter Pankreasnekrose angeht, ist man noch nicht zu einer Einigung gekommen. Während einige Forscher eine Vermehrung der Lipase annehmen, behaupten andere, sie erleide quantitativ keine Veranderungen. Auch für die Bestimmung der Lipase haben wir verschiedene Verfahren, unter denen das am meisten Angewandte das Verfahren von Rona-Michaelis ist. Natürlich hat dieses Verfahren auch manches Nacheilige. Der Verfasser hat Willstätter, Waldschmitz und Leitz'sche methode angewandt. Er hat bei Versuchshunden durch Einführung von Olivenöl, Galle, in den Ductus pancreaticus akute Pankreasnekrose hervorgerufen, um die Menge der Serumlipase in bestimmten Zeitabständen festzustellen. Dadurch konnte er das quantitative Verhalten der Lipase im Serum in folgende 5 Formen eingeteilt: 1) Steigende Form, bei der die Lipase nach der Operation allmählich zunimmt. 2) Bergform, bei der sie nach einer Zunahme wieder abnimmt. 3) Talform, bei der sie nach einer Abnahme quantitative gesteigert wird. 4) Absteigform, bei der sie nach der Operation allmahlich abnimmt. 5) Wellenform, bei der die Zu- und Abnahme sich entsprechend folgen. Unter diesen Formen zeigen die 1. und 2. eine ganz steile Erhöhung an, d.h. die quantitativen Veränderungen der Serunmlipase Bind auffallend gross, während die übrigen drei Formen nur langsame Veränderungen geben. Die Tiere, die den ersteren Formen angehören, sterben in kurzer Zeit, während die Tiere, die zu den letzteren Formen gehören, verhältnismässig lang am Leben bleiben. Ferner hat der Verf. in bestimmten Zeitäbstanden Blutserum und Bauchexsudate herausgenommen und die Menge der Lipase in heiden Flüssigkeiten bestimmt, um quantitativen Zusammenhang zwischen den Lipasen der beiden Flüssigkeiten festzustellen Dabei wurden folgende 4 Formen beobachtet: 1) I. Form, bei der die Lipase der Bauchexsudate abnimmt, während die Serumlipase zunimmt. 2) II. Form, bei der die Lipase der Bauchexsudate zunimmt, während die Serumlipase abnimmt. 3) III. Form, bei der die Lipase der Bauchexsudate sowie die Serumlipase zunehmen. 4) IV. Form, bei der die beiden Lipasen abnehmen. Es muss angenommen werden, dass bei der I. Form die Lipase der Bauchexunate ins Blut resorbiert wird, und class bei der II. Form dagegen eine solche Resorption nicht zustande kommt und infolgedessen das Serum nicht zunimmt. Ferner nimmt der Verf. an, dass bei der III. Form die Vermehrung der Lipase in den Exsudaten so intensiv vonstatten ging, dass auch die Serumlipase zunahm. Bei der IV. Form muss die Lipase der Bauchexsudate zwar in das Blut resorbiert worden sein, wurde aber sofort aus der Niere ausgeschieden, so dass ihre Vermehrune in den beiden Flüssigkeiten nicht eintrat. en-copyright= kn-copyright= en-aut-name=NakagawaYoshio en-aut-sei=Nakagawa en-aut-mei=Yoshio kn-aut-name=中川美雄 kn-aut-sei=中川 kn-aut-mei=美雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=3 article-no= start-page=626 end-page=634 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19410331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ein Fall von Dottergangfisteln kn-title=臍腸管瘻ノ1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) Bericht über einen Fall. von Dottergangfisteln, die sich bei einem Knaben von 7 Lebensmonaten infolge von angeborener Missbildung entwickelt hatten. Die Schleimhaut der Fistel prolabierte ein wenig. Durch Ausschneidung des Fistelgangs wurde eine vollständige Heilung erzielt. 2) Beim Vorhandensein einer solchen Fistel kann es schliesslich zum Prolaps von Darmkanälchen kommen. Die Prognose ist dann eine durchaus ungünstige. Die-moglichst frühzeitige Exstirpation des Fistelgangs wird als die Methode der Wahl angesehen. en-copyright= kn-copyright= en-aut-name=NakagawaYoshio en-aut-sei=Nakagawa en-aut-mei=Yoshio kn-aut-name=中川美雄 kn-aut-sei=中川 kn-aut-mei=美雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=2 article-no= start-page=380 end-page=388 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19410228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ein Fall von Mischgeschwulst an der Inguinalgegend kn-title=鼠蹊部混合腫瘍ノ1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Der Pat. war ein 45 jähriger Mann. Vor drei Jahren hat er einen Tumor in der Mitte der rechten Inguinalgegend bemerkt. Der Tumor, der am Anfang nicht grosser als die Spitze des Kleinfingers war, nahm allmahlich an Grösse. zu und wurde endlich so gross wie eine Faust. Beim operativen Eingriff liess sich der Tumor ohne Schwierigkeit exstirpieren, da er unter der Haut entstanden und mit der Umgebung nicht verwachsen war. Er war 11×6×9cm gross. Seine Schnittflämche zeigte eine Reihe von kleinen rundlichen Teilen. Seine Peripherie zeigte eine myxomatöse braune Farbe. In der Mitte lag ein lipomatöser Teil, der gelblich gefämrbt war. An der Grenze dieser beiden Teile war ein Knorpel vorhanden. Die histologische Untersuchung ergab, dass es sich hier um ein Fibro-myxo-lipo-chondrom handelte. Es war nämlich eine mesenchymare Mischgeschwulst, die subkutan in der rechten Inguinalgegend auftrat. Wegen dieser Lage stellte dieser Tumor eine besondere Seltenheit dar. en-copyright= kn-copyright= en-aut-name=NakagawaYoshio en-aut-sei=Nakagawa en-aut-mei=Yoshio kn-aut-name=中川美雄 kn-aut-sei=中川 kn-aut-mei=美雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=1 article-no= start-page=154 end-page=161 dt-received= dt-revised= dt-accepted= dt-pub-year=1941 dt-pub=19410131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ein Fall von kleinem Hodentumor kn-title=最小ナル睾丸腫瘍 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Der Verf. berichtet über einen Fall von einem äusserst kleinen Seminom, das er operativ behandelt hat. Der Pat. war ein Knabe von 31 Monaten; er hatte in dem rechten Hoden einen 2.5×1.5cm grossen Tumor. Aus statistischen Beobachtungen wissen wir, dass unter den Hodentumoren von Kindern Krebs am häufigsten vorkommt. weniger häufig Teratam, am wenigsten oder vielmehr sehr selten Mischgeschwulst und Seminom. Was das Entstehungsalter anbetrifft, so begegnetman diese Neubildungen am häufigsten im Zeitraum von der Geburt bis zum Alter von 5 Jahren., Die Therapie besteht in sofortiger Exstirpation der Neubildungen, und zwar nicht nur in malignen Fällen, sondern auch in solchen Fällen, in denen die Bösartigkeit des Tumors nicht sicher ist.Nur die sofortige Exstirpation befreit das Kind von den so oft eintretenden Metastasen und Rezidiven von Hodentumor, die sich oft äusserst bösartig entwickeln können. en-copyright= kn-copyright= en-aut-name=NakagawaYoshio en-aut-sei=Nakagawa en-aut-mei=Yoshio kn-aut-name=中川美雄 kn-aut-sei=中川 kn-aut-mei=美雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue=2 article-no= start-page=37 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=1951 dt-pub=19510331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=過去五ケ年間當教室に入院した膽嚢症患者に試みた臨牀的諸統計（承前） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山岡憲二 kn-aut-sei=山岡 kn-aut-mei=憲二 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川二郎 kn-aut-sei=中川 kn-aut-mei=二郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學第一（山岡）内科教室 affil-num=2 en-affil= kn-affil=岡山醫科大學第一（山岡）内科教室 END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue=1 article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=1951 dt-pub=19510131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=過去五ケ年間當教室に入院した膽嚢症患者に試みた臨牀的諸統計 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山岡憲二 kn-aut-sei=山岡 kn-aut-mei=憲二 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川二郎 kn-aut-sei=中川 kn-aut-mei=二郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學第一（山岡）内科教室 affil-num=2 en-affil= kn-affil=岡山醫科大學第一（山岡）内科教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=8 article-no= start-page=1675 end-page=1685 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the immunity of Newcastle disease virus Part III: The toxin of Newcastle disease virus kn-title=Newcastle Disease Virusの免疫に関する研究 第3編 Newcastle disease virusの毒素の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=There have been made few reports on the virus toxins except those of psitacossis-lymphogranuloma and influenza groups, and, as to the Newcastle disease virus, the existence of its toxin is only presumed by Upton. Considering the fact that this toxin is neutralized by the immune serum of Newcastle disease virus, this toxin seems to have some relationship with the immunity of the virus. Therefore, the author makes reports on the fact that the Newcastle disease virus has its toxin, and about the various results gained by studying its properties. 1) The intraveneous and intraabdominal injection of the chorioallantoic fluid inoculated with this virus, could kill the injected hosts such as chickens and mice. In the case of chickens, it took less than 24 hours to kill, and in the case of mice, the animals died with convulsion. 2) This toxic substance seems to be the virus itself, because the virulence of this toxin and the concentration of virus went parallel to each other and this toxin was not able to be separated from the virus by means of kaolin-adsorption and-dissociation. 3) This virus proliferated for 48 hours in embryonated eggs showed greater virulence than that proliferated for 24 hours. In this test, however, the quantities of virus were adjusted that their infectious titer might be the same one. 4) If this virus is kept at 6°C, it lost its virulence earlier than the infectious titer. Against heating, however, this virulence was a little more stable than the infectious titer, and, in the presence of formalin, these two were lost parallel to each other. 5) The lethal toxin of Newcastle disease virus was neutralized by antiserum and was also neutralized in the bodies of immunized hosts. en-copyright= kn-copyright= en-aut-name=NakagawaFumio en-aut-sei=Nakagawa en-aut-mei=Fumio kn-aut-name=中川文雄 kn-aut-sei=中川 kn-aut-mei=文雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=8 article-no= start-page=1661 end-page=1673 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the immunity of Newcastle disease virus Part II: The antigenicity of Newcastle disease virus produced from the hosts' organs infected with it kn-title=Newcastle Disease Virusの免疫に関する研究 第2編 感染動物臓器よりつくつたNewcastle virus vaccineの抗原性に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although there are many investigations about the effects of various antigens of the Newcastle disease virus, the author makes reports on the antigenicity of this virus and also on the immune effects of various fractions obtained on the way of purification of the used materials. The materials chosen for this research were the fowl brains and chick-embryos infected with this virus. 1) In the case where the tissue emulsion was chosen as vaccine, the emulsized tissue as it was had very remarkable effect. 2) Whether formal dehyde or merzonin may be used for inactivation, the immune effect remained to the same degree. 3) The condensation of chorioallantoic fluid to one-fifth of it by Brumfield's methanol sedimentation method, showed great loss of antigenicity, having the hemagglutination and infectious titers of only one-second of those of the original chorioallantoic fluid. 4) The purified and non-purified antigens of the infected chorioallantoic fluid and of 10% emulsions of the fowl brains and chick-embyros were inoculated into the hearts of chickens. Then the purified antigen of chorioallantoic fluid and non-purified antigen of emulsized chick-embryos showed better results than the others, in all of the tests of sen sitized cell agglutination, hemagglutination and of protection against infection. 5) The Newcastle disease virus had its kaolin-adsorption and -dissociation points at pH 4.0 and 8.0 respectively, and the adsorption on kaolin was well performed by repeating it twice. 6) Studying the nitrogen quantity and infectious titer of the kaolin-adsorption and -dissociation products of 10% fowl brain emulsions, the supernatant of adsorption was rich in tissue components and poor in viruses, but that of dissociation was rich in viruses and poor in tissue components. 7) The portion, which is rich in tissue elements and poor in viruses, showed greater antigenicity than the other portion, when they were inactivated and inoculated into chick-hearts. Considering the above-mentioned results, the emulsized chick-embryos as these are seem to be the best one as the antigen of Newcastle disease virus, in view of the intensity of the antigenicity, and the possibility of intramuscular injection and mass production. en-copyright= kn-copyright= en-aut-name=NakagawaFumio en-aut-sei=Nakagawa en-aut-mei=Fumio kn-aut-name=中川文雄 kn-aut-sei=中川 kn-aut-mei=文雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学教室 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=8 article-no= start-page=1647 end-page=1660 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the immunity of Newcastle disease virus Part I: The immune reaction of Newcastle diease virus kn-title=Newcastle Disease Virusの免疫に関する研究 第1編 Newcastle Disease Virusの免疫反応に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although there have been made many reports that the infection and vaccination of Neweastle disease virus can produce high immunity, the vaccination in the case of virus diseases is, still now, not sufficiently effective. This experiment is performed to make some contribution to the production of general virus vaccines, by studying the problems of immunity engendered with inactivated vaccines. Here the author makes reports on the results of re-examination of various serum reactions, which are often applied to immune rections, and, at the same time, on the various new facts observed through this experiment. The materials used for this experiment were the emulsions of the fowl brains and embryos, and chorioallantoic fluid. The strain of virus used was Miyadera strain of Newcastle disease virus. 1) The LD50 of this strain for the embryonated eggs, 3-day chickens, 20-day chickens and 35-day chickens were 10-11.5, 10-15.5, 10-13.1 and 10-4.8 respectively. Therefore, the infectious titer falls remarkably as the age of chickens increases. 2) The positive titers of Hirst's phenomenon of this Miyadera strain were from 320 to 1280, and hemagglutination test with fowl immune serum showed inhibitation titers from 320 to 640. 3) The guinea-pig serum, immunized with Newcastle disease virus-infected chorioallantoic fluid, showed complement fixation with the antigen of chorioallantoic membrane, with the antigen separated with kaolin from chorioallantoic fluid, and the antigen purified from chick-embryos. In this case, the condensation of purified antigen is not so necessary. 4) Complement fixation inhibitation is completed by using the fowl immune serum. 5) The neutralization with fowl immune serum drawn on the fifteenth and thirty-fifth day after injection of the antigen, showed the log. neutralization of 3.1 and 3.7 respectively. 6) The sensitized red cell agglutination was tested with the serum drawn, as days went by after the inoculation, from the adult fowls inoculated with Newcastle disease virus-infected chorioallantoic fluid. This agglutination test showed the maximum positive titer of 640 on the sixth or eighth day and disappeared on the twenty-second day after the inoculation. 7) As to the hemagglutination inhibitation test, however, it showed the maximum titer of 640 on the twenty-second day, but, on the thirty-fifth day, it fell to fairly low titer. 8) The log. neutralization showed the maximum titer of 5.5 on the twenty-second day after inoculation, but, on the thirty-fifth day, it fell to 5.2, the same titer as that on tho twenty-second day. en-copyright= kn-copyright= en-aut-name=NakagawaFumio en-aut-sei=Nakagawa en-aut-mei=Fumio kn-aut-name=中川文雄 kn-aut-sei=中川 kn-aut-mei=文雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学教室 END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=3 article-no= start-page=1 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=19921125 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lural Life in Kanagawa Prefecture in the Late Meiji Era (I) kn-title=明治後期の神奈川県一農村における村民生活―神奈川県都筑郡中川村の「村是調査書］による検討―（I） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KandatsuHaruki en-aut-sei=Kandatsu en-aut-mei=Haruki kn-aut-name=神立春樹 kn-aut-sei=神立 kn-aut-mei=春樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=1-2 article-no= start-page=125 end-page=150 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930525 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Rural Life in Kanagawa Prefecture in the Late Meiji Era (II) kn-title=明治後期の神奈川県一農村における村民生活―神奈川県都筑郡中川村の「村是調査書」による検討―(2) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KandatsuHaruki en-aut-sei=Kandatsu en-aut-mei=Haruki kn-aut-name=神立春樹 kn-aut-sei=神立 kn-aut-mei=春樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=9-10 article-no= start-page=1127 end-page=1134 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the reactivity of human basophilic leukocytes Part 2. Correlation between morphological changes of human basophilic leukocytes and histamine release after stimulation with Ca. ionophore A23187 kn-title=好塩基球の反応性に関する研究 第2編 Ca. ionophore A23187刺激時の好塩基球の経時的形態的変化とヒスタミン遊離 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Morphological changes in human basophils from 11 atopic asthmatics were observed in whole blood smears with respect to histamine release after the cells were challenged by Ca. ionophore A23187. A decreased number of basophils and granules in the cells as well as increase in cell diameters were observed upon histamine release after stimulation with Ca. ionophore A23187. Compared to cell reactions to antigen or anti-IgE, Ca. ionophore A23187 produced both more gradual morphological changes and histamine release and induced greater increases in the diameter of the basophils. No change in the ratio of the short to long axis diameter was observed after stimulation with Ca. ionophore A23187. The results suggest that basophils do not show any increased mobility upon stimulaion with Ca. ionophore A23187, though antigen and anti-IgE stimulation induces increased motility in these cells. en-copyright= kn-copyright= en-aut-name=NakagawaSaburo en-aut-sei=Nakagawa en-aut-mei=Saburo kn-aut-name=中川三郎 kn-aut-sei=中川 kn-aut-mei=三郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=好塩基球 kn-keyword=好塩基球 en-keyword=ヒスタミン遊離 kn-keyword=ヒスタミン遊離 en-keyword=形態的変化 kn-keyword=形態的変化 en-keyword=Ca. ionophore A23187 kn-keyword=Ca. ionophore A23187 END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=9-10 article-no= start-page=1119 end-page=1126 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the reactivity of human basophilic leukocytes Part 1. Correlation between morphological changes of human basophilic leukocytes and histamine release after stimulation with antigen or anti-IgE kn-title=好塩基球の反応性に関する研究 第1編 抗原，抗ヒトIgE刺激時の好塩基球の経時的形態的変化とヒスタミン遊離 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Morphological changes in human basophils from atopic asthmatics were observed in whole blood smears with respect to histamine release after stimulation with antigen or anti-IgE. Histamine was rapidly released and was accompanied by morphological changes in basophils upon stimulation with antigen and anti-IgE. A decreased number of basophils and morphological changes including increased cell diameters, increased ratios of the short to long axis diameters, and decreased intracellular granule counts were observed upon the release of histamine after antigen and anti-IgE stimulation. Antigen stimulus induced both more rapid histamine release and morphological changes than anti-IgE stimulation. en-copyright= kn-copyright= en-aut-name=NakagawaSaburo en-aut-sei=Nakagawa en-aut-mei=Saburo kn-aut-name=中川三郎 kn-aut-sei=中川 kn-aut-mei=三郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=好塩基球 kn-keyword=好塩基球 en-keyword=形態的変化 kn-keyword=形態的変化 en-keyword=特異抗原 kn-keyword=特異抗原 en-keyword=抗ヒトIgE kn-keyword=抗ヒトIgE END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=3 article-no= start-page=231 end-page=236 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of transverse colon cancer with remarkable extramural invasion to stomach and jejunum kn-title=壁外性に腫瘤を形成し胃・小腸浸潤を示した横行結腸癌の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 77-year-old woman was admitted to our hospital due to abdominal pain and body weight loss. A palpable mass the size of an infant's head was tender on palpation and identified as an epigastric lesion. Colonoscopic examination revealed stenosis of the transverse colon, although no intraluminal growth of the tumor was found. The histologic findings of the biopsy material were poorly differentiated and/or undifferentiated cells. Abdominal CT scan showed an irregular-shaped tumor with a diameter of 10cm invading the stomach and jejunum. We performed an operation under a diagnosis of extramurally growing cancer or malignant lymphoma of the colon. Partial resection of the transverse colon was done by distal gastrectomy and partial resection of the jejunum. Histologic examination of the operative specimens revealed moderately differentiated adenocarcinoma of the transverse colon, prominently proliferating into the surrounding tissues. The finding of a long stenotic lesion and extramural compression by colonography are characteristic of this tumor, based on a review of 43 literature reports in Japan. en-copyright= kn-copyright= en-aut-name=HamanoRyosuke en-aut-sei=Hamano en-aut-mei=Ryosuke kn-aut-name=濱野亮輔 kn-aut-sei=濱野 kn-aut-mei=亮輔 aut-affil-num=1 ORCID= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=大塚眞哉 kn-aut-sei=大塚 kn-aut-mei=眞哉 aut-affil-num=2 ORCID= en-aut-name=KimuraYuuji en-aut-sei=Kimura en-aut-mei=Yuuji kn-aut-name=木村裕司 kn-aut-sei=木村 kn-aut-mei=裕司 aut-affil-num=3 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=4 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=徳永尚之 kn-aut-sei=徳永 kn-aut-mei=尚之 aut-affil-num=5 ORCID= en-aut-name=MiyasouHideaki en-aut-sei=Miyasou en-aut-mei=Hideaki kn-aut-name=宮宗秀明 kn-aut-sei=宮宗 kn-aut-mei=秀明 aut-affil-num=6 ORCID= en-aut-name=TsunemituYousuke en-aut-sei=Tsunemitu en-aut-mei=Yousuke kn-aut-name=常光洋輔 kn-aut-sei=常光 kn-aut-mei=洋輔 aut-affil-num=7 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=8 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=岩川和秀 kn-aut-sei=岩川 kn-aut-mei=和秀 aut-affil-num=9 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=6 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=7 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=8 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=9 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=10 en-affil= kn-affil=国立病院機構福山医療センター　外科 en-keyword=大腸癌 (colon cancer) kn-keyword=大腸癌 (colon cancer) en-keyword=壁外性発育 (extraluminal growth) kn-keyword=壁外性発育 (extraluminal growth) END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=正常とアカタラセミアなマウスの間に全身照射による放射線感受性に差異はない kn-title=No Different Sensitivity in Terms of Whole-body Irradiation Between Normal and Acatalasemic Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaShinya en-aut-sei=Nakagawa en-aut-mei=Shinya kn-aut-name=中川慎也 kn-aut-sei=中川 kn-aut-mei=慎也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue= article-no= start-page=35 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=好塩基球からのヒスタミン遊離に関する研究. 3. 抗ヒトIgE に対する好塩基球の反応性と末梢血好酸球増多 kn-title=Studies on the release of histamine from basophils. 3. Correlation between basophil reactivity to anti-IgE and blood eosinophilia en-subtitle= kn-subtitle= en-abstract=末梢血好酸球増多を示す気管支喘息14症例について,抗ヒトIgE による好塩基球からのヒスタミン遊離を検討した. ハウスダストに対する皮内反応およびRASTが陽性を示す症例群(groupI)では,血清IgE値が高く,また抗ヒトIgEによるMax. % ヒスタミン遊離も高く(50.7士5.0%),そのdoseresponse curveは抗ヒトIgE添加濃度が高くなるにつれて上昇する傾向を示した.一方種々のアレルゲンエキスに対する皮内反応が陰性で,かつRAST も陰性を示す症例群(group II)では,血清IgE値が低く,また抗ヒトIgEによるMax. % ヒスタミン遊離も低く(10.5士1.7%),そのdose-response curveは全般的に低く,抗ヒトIgE添加濃度が高いところではむしろ抑制される傾向を示した. kn-abstract=Histamine release from basophils induced by anti-IgE was examined in 14 asthmatic subjects with blood eosinophilia. The subjects were divided into two groups; group I (with blood eosinophilia, positive skin test and positive RAST to house dust) and group II (with blood eosinophilia, negative skin test to various allergens and negative RAST to house dust). 1. Serum IgE levels in group I were much higher than those in group II. 2. Maximum percent histamine release induced by anti-IgE was much higher in group I than in group II. 3. Dose-response curve of anti-IgE-induced histamine release in group I showed consistent increase as anti-IgE concentrations increased. while, dose-response curve in group II was very low. These findings suggested that blood eosinophilia in group I might be elicited relating to IgE-mediated reaction. However, mechanism causing eosinophilia in group II was not clear in the present study. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=3 ORCID= en-aut-name=MifuneMasaaki en-aut-sei=Mifune en-aut-mei=Masaaki kn-aut-name=御般政明 kn-aut-sei=御般 kn-aut-mei=政明 aut-affil-num=4 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=5 ORCID= en-aut-name=NakagawaSaburo en-aut-sei=Nakagawa en-aut-mei=Saburo kn-aut-name=中川三郎 kn-aut-sei=中川 kn-aut-mei=三郎 aut-affil-num=6 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue= article-no= start-page=7 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19841130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for patients with chronic obstructive lung disease kn-title=Studies on the release of histamine from basophils 4. Difference between house dust- and Candida-induced secretion en-subtitle= kn-subtitle= en-abstract=ハウスダストあるいはカンジダが特異抗原である気管支喘息30例を対象に,それぞれの抗原刺激時の好塩基球からのヒスタミン遊離を,抗ヒトIgEによる遊離と比較検討した. 1. ハウスダストが原因抗原である症例の好塩基球からのヒスタミン遊離は,抗原刺激時41.8%,抗ヒトIgE刺激時40.8%であった. 2. カンジダが原因抗原である症例の好塩基球からのヒスタミン遊離は,抗原刺激時27.1%,抗ヒトIgE刺激時32.2%であった. 3. ハウスダストと抗ヒトIgEによる好塩基球からのヒスタミン遊離は,ほぼ同様の値を示した. 一方カンジダと抗ヒトIgEによるヒスタミン遊離の間には有意の 相関関係はみられなかった. kn-abstract=Histamine releasse from basophils induced by house dust and C. albicans was examined in 30 patients with bronchial asthma. House dust and C. albicans caused a significant amount of histamine release in subjects with a RAST score to corresponding allergen. A close correlation was found between house dust- and anti-IgE-induced histamine release. However, histamine release induced by C. albicans was considerably different from the release induced by anti-IgE. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=3 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=4 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=5 ORCID= en-aut-name=NakagawaSaburo en-aut-sei=Nakagawa en-aut-mei=Saburo kn-aut-name=中川三郎 kn-aut-sei=中川 kn-aut-mei=三郎 aut-affil-num=6 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学第2内科 affil-num=6 en-affil= kn-affil=岡山大学第2内科 affil-num=7 en-affil= kn-affil=岡山大学第2内科 END start-ver=1.4 cd-journal=joma no-vol=2009 cd-vols= no-issue=1 article-no= start-page=111 end-page=116 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20091111 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Design Support of Transportation Routing for a Multi Layered Factory en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recently, it becomes important to improve transportation capability to attain high productivity in manufacturing. One of the necessary schemes to attain the purpose is that the floor layout is initially to be optimized. After the floor layout is determined, reasonable equipment position for transportation is decided. Then the design of the transportation route is to be determined. In this paper, design support system for transportation routing, based on agent method is proposed. To optimize the transportation route, the working space by the side of the equipment is to be prepared. Starting from given floor layout of a three layered factory, an appropriate transportation route is pursuit using Ant algorithm. To check the applicability of the proposed method, case studies are carried out under various constraints and objective functions, and its effects were verified. en-copyright= kn-copyright= en-aut-name=NakagawaKoji en-aut-sei=Nakagawa en-aut-mei=Koji kn-aut-name=中川光路 kn-aut-sei=中川 kn-aut-mei=光路 aut-affil-num=1 ORCID= en-aut-name=KonishiMasami en-aut-sei=Konishi en-aut-mei=Masami kn-aut-name=小西正躬 kn-aut-sei=小西 kn-aut-mei=正躬 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=5 article-no= start-page=1609 end-page=1615 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and Experimental Studies on the Artificial Hypotensive Operation. Part Ⅴ. Experimental Comparative Studies on Anesthesia under Normal Blood Pressure and Hypotention Nucleic Acid in Dogs kn-title=人為低血圧下手術に関する臨床的ならびに実験的研究 第5編 核酸の消長からみた正常血圧下麻酔と人為低血圧下麻酔との実験的比較検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Male dogs were anesthetized with endotracheal anesthesia under the normal and the artificial hypotensive blood pressure and the influences of the anesthesia on the nucleic acid metabolism in the liver and the kidney were studied. 1) No marked degenerative changes were generally observed in both normal and hypotensive groups by anesthesia. 2) The influences on the nucleic acid metabolism were very slight in both groups. 3) In the hypotensive group, dilatation of the capillary vessels in the kidney and liver was observed. 4) The changes of R.N.A. seemed a little greater than those of D.N.A. in both groups, but no definite tendency was hardly observed. 5) Histological changes including the change of nucleic acid seemed stronger as the duration of anesthesia became longer and the grade of hypotention became greater. However, no marked difference observed between 2 and 3.5 hours of anesthesia and between 20% and 40% of hypotensive rate. en-copyright= kn-copyright= en-aut-name=NakagawaToshimi en-aut-sei=Nakagawa en-aut-mei=Toshimi kn-aut-name=中川俊美 kn-aut-sei=中川 kn-aut-mei=俊美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=5 article-no= start-page=1601 end-page=1608 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and Experimental Studies on the Artificial Hypotensive Operation. Part Ⅳ. Comparative Studies of Surgical Operations under Normal Blood Pressure and Hypotension regarding Renal Function kn-title=人為低血圧下手術に関する臨床的ならびに実験的研究 第4編 腎機能からみた正常血圧下手術と人為低血圧下手術との比較検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The cases of pulmonary resection under endotracheal anesthsia of closed circulation were divided into two groups, i.e. the normal blood pressure group and the hypotensive group, and the glomerular filtration rate (C.F.R.) and the tubular reabsorption rate (T.R.R.) were evaluated in each group. 1) G.F.R. markedly decreased during operation in both groups and restored almost to the preoperative G.F.R. after recovery. 2) The hypotensive group showed a little more marked decrease of G.F.R. during and after operation than the normal group. The volume of urine showed a similar change to G.F.R. 3) T.R.R. showed no change before, during and after operation proved to be due to the decrease of G.F.R. en-copyright= kn-copyright= en-aut-name=NakagawaToshimi en-aut-sei=Nakagawa en-aut-mei=Toshimi kn-aut-name=中川俊美 kn-aut-sei=中川 kn-aut-mei=俊美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=5 article-no= start-page=1589 end-page=1600 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and Experimental Studies on the Artificial Hypotensive Operation. Part Ⅲ. Comparative Studies of Surgical Operations under Normal Blood Pressure and Hypotension with Measuring of the Liver Function kn-title=人為低血圧下手術に関する臨床的ならびに実験的研究 第3編 肝機能からみた正常血圧下手術と人為低血圧下手術との比較検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influences of endothracheal anesthesia upon the liver function in the preoprative stage, during the operation and after the recovery was estimated measuring the serum bilirubin and BSP test and the results in both groups were compared. 1) The total serum bilirubin increased in both groups slightly during the opeartion and mostly after the recovery. It showed a tendency to decrease gradually at the third postoperative day. But its mean value was larger in the hypotensive group than in the normal group during the operation. After the operation, however, it was rather more in the normal group. 2) The increase of the total serum bilirubin during the operation was mostly dut to the increase of the direct and indirect bilirubin. 3) BSP-test during the operation showed an increase of 22.5%-25.7% in the blood, but it showed a marked restoratation after recovery in both groups. BSP in the blood of the normal group during the operation seemed more than that of the hypotensive group, but not different after recovery. en-copyright= kn-copyright= en-aut-name=NakagawaToshimi en-aut-sei=Nakagawa en-aut-mei=Toshimi kn-aut-name=中川俊美 kn-aut-sei=中川 kn-aut-mei=俊美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=5 article-no= start-page=1575 end-page=1587 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and Experimental Studies on the Artificial Hypotensive Operation. Part Ⅱ. Comparative Studies of Surgical Operations under Normal Blood Pressure and Hypotension with Analysis of Blood Gases kn-title=人為低血圧下手術に関する臨床的ならびに実験的研究 第2編 血液ガスからみた正常血圧下手術と人為低血圧下手術との比較検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The group of pulmonary resections under normal blood pressure and the group of those under endotracheal anesthesia of closed circulation type were compared. The arterial blood gas content was measured at the pre-operative stage, directly after the intubation, during operation and after recovery using Van Slyke manometer. The results were as follows: 1) The O(2) content of the arterial blood showed a decreasing either under normal blood pressure of under hypotensive group, most strikingly during the operation moderately after recovery, and slightly directly after the intubation. The mean values of both groups were compared. The O(2) content of the arterial blood had more definite tendency of decreasing in the hypotensive group than the normal group, but it was not significant. 2) The CO(2) content in the arterial blood in both groups generally decreased slightly directly after intubation and most strikingly during the operation. After recovery it became rather more in the normal group than before the operation, while that in the hypotensive group decreased slightly and still less than before the operation. 3) Throughout all cases we found the decreasing of total blood gases especially during the operation, namely there was a decreasing tendency of general metabolic function of gases, which was regarded to be stronger in the hypotensive group than in the normal group. 4) Though the decreasing tendency of metabolic function of gases was rather stronger in the hypotensive group than that in the normal group, the value of arterial blood was rather better in the hypotensive group. This value in both groups increased with the lapse of the stages of operation. 5) In the cases, in which the arterial blood value more than 3.0 already before the operation, we must be careful to determine the indication of pulmonary resection. We must pay close attention to it, because the patient is apt to fall into risk postoperatively even if we can safely finish the operation. en-copyright= kn-copyright= en-aut-name=NakagawaToshimi en-aut-sei=Nakagawa en-aut-mei=Toshimi kn-aut-name=中川俊美 kn-aut-sei=中川 kn-aut-mei=俊美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=5 article-no= start-page=1567 end-page=1574 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=19580531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and Experimental Studies on the Artificial Hypotensive Operation. Part 1. Comparative Studies of Surgical Operations and Ⅲ Effects under the Normal Blood Pressure and Artificial Hypotensive Anesthesia kn-title=人為低血圧下手術に関する臨床的ならびに実験的研究 第1編 正常血圧下手術と人為低血圧下手術との臨床成績ならびに副作用の比較検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) The endotracheal anesthesia of closed circulation type was applicated to 259 cases and Hexamethonium bromide (C(6)) and inclining of the operating table were used for 30 cases of pulmonary resection. 2) The dose of C(6) for the artificial hypotensive operation was on the average of 63 mg and the maximum descending of blood pressure was on the average of 34% . Generally we got to the aimed hypotention by the intravenous injection of C(6) 50 mg and inclining of the operating table. But the additional intravenous injection of C(6) did not effected so strongly as the first one. 3) The mean amount of the lost blood in the hypotensive group less than half of that in normal groups. In the hypotensive group there was a tendency to decrease the bleeding even in those cases, in which we could not get the aimed hypotension. 4) The blood and saline used during pneumectomy for hypotensive group, were less than half of those used in the normal group. 5) The tendency of postoperative bleeding as a complication was stronger in the hypotensive group. In one hypotensive case we could only make thoracotomy, because of hypoxia, but in other cases we found no noted complication. en-copyright= kn-copyright= en-aut-name=NakagawaToshimi en-aut-sei=Nakagawa en-aut-mei=Toshimi kn-aut-name=中川俊美 kn-aut-sei=中川 kn-aut-mei=俊美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1（陣内）外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=11-12 article-no= start-page=2145 end-page=2150 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Autopsy Case of Hypoplastic Anemia occurring during the Treatment with Dilantin (Aleviatin) kn-title=Dilantin（Aleviatin）使用中に発症した再生不良性貧血の一剖検例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The authors report a case of hypoplastic anemia which suddenly attacked a female, age 23, under the treatment with Dilantin (Aleviatin), an anticonvulsant and drove her to death three weeks after the onset of the disease in spite of various therapies. The chief complaints were a high fever, subcutaneous and gingival bleeding and pharyngealgia. On admission severe hyperchromic anemia, severe leukopenia with lymphocytosis (95%), thrombopenia, hemorrhagic diathesis, angina and typical myelogram were noticed. At autopsy the bone marrow showed hypoplasia and maturation arrest. It is emphasized that the single treatment with Dilantin may produce severe hematopoietic disturbance such as hypoplastic anemia that have not been reported. en-copyright= kn-copyright= en-aut-name=NakagawaShoso en-aut-sei=Nakagawa en-aut-mei=Shoso kn-aut-name=中川昌壮 kn-aut-sei=中川 kn-aut-mei=昌壮 aut-affil-num=1 ORCID= en-aut-name=NishimuraAtsushi en-aut-sei=Nishimura en-aut-mei=Atsushi kn-aut-name=西村惇 kn-aut-sei=西村 kn-aut-mei=惇 aut-affil-num=2 ORCID= en-aut-name=OgoHiroshi en-aut-sei=Ogo en-aut-mei=Hiroshi kn-aut-name=小河博之 kn-aut-sei=小河 kn-aut-mei=博之 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部妹尾病理学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=11-12 article-no= start-page=2137 end-page=2144 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Case of Cushing's Syndrom kn-title=Cushing氏症候群の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The authors report a case of Cushing's syndrom with typical clinical pictures, that is, generalized adipositas, full moon face, cutaneous striae, hypertension, osteoporosis, hyperglycemia and excessive secretion of 17-ketosteroid and 17-hydrooxycorticoid. Although the patient had various clinical examination, the primary pathologic site was not found. It might be thought that the site is benign, since no general symptoms became worse during long course. en-copyright= kn-copyright= en-aut-name=WatanabeHaruo en-aut-sei=Watanabe en-aut-mei=Haruo kn-aut-name=渡辺春生 kn-aut-sei=渡辺 kn-aut-mei=春生 aut-affil-num=1 ORCID= en-aut-name=MonobeTaisei en-aut-sei=Monobe en-aut-mei=Taisei kn-aut-name=物部大成 kn-aut-sei=物部 kn-aut-mei=大成 aut-affil-num=2 ORCID= en-aut-name=NakagawaShoso en-aut-sei=Nakagawa en-aut-mei=Shoso kn-aut-name=中川昌壮 kn-aut-sei=中川 kn-aut-mei=昌壮 aut-affil-num=3 ORCID= en-aut-name=ShindoMinoru en-aut-sei=Shindo en-aut-mei=Minoru kn-aut-name=進藤稔 kn-aut-sei=進藤 kn-aut-mei=稔 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=11-12 article-no= start-page=2133 end-page=2136 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Experimental Study on Occult Blood in Feces (Experiment by Oral Administration of Human Blood) kn-title=糞便潜血反応の実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Examinations of occult blood in feces were performed after a certain amount of blood treated previously with hydrochloric acid limonnde was given into the stomach or duodenum through a Levin tube. The follwing results were obtained. 1. All the cases were positive in the reaction after the administration of more than 2 ml. of the blood. 2. No significant difference in the reaction between intragastric and intraduodenal administration. 3. The intensity of the positive reaction became weak as the acidity in gastric juice became high. 4. The longevity of the positive reaction was prolonged with larger amount of the blood given but they were not proportional when the amount of more than 3 ml. of the blood was administrated. After 4 days all the cases showed negative reaction. en-copyright= kn-copyright= en-aut-name=NakagawaShoso en-aut-sei=Nakagawa en-aut-mei=Shoso kn-aut-name=中川昌壮 kn-aut-sei=中川 kn-aut-mei=昌壮 aut-affil-num=1 ORCID= en-aut-name=HiranoYutaka en-aut-sei=Hirano en-aut-mei=Yutaka kn-aut-name=平野寛 kn-aut-sei=平野 kn-aut-mei=寛 aut-affil-num=2 ORCID= en-aut-name=YamamotoYuushi en-aut-sei=Yamamoto en-aut-mei=Yuushi kn-aut-name=山本裕士 kn-aut-sei=山本 kn-aut-mei=裕士 aut-affil-num=3 ORCID= en-aut-name=GotoShoichiro en-aut-sei=Goto en-aut-mei=Shoichiro kn-aut-name=後藤昭一郎 kn-aut-sei=後藤 kn-aut-mei=昭一郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1711 end-page=1722 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Bile Pigment Precursors in Erythrocytes Part 2. Relationship between Bile Pigment Precursors and Free Porphyrin in Erythrocytes kn-title=赤血球内Bile Pigment Precursorsに関する研究 第2編 赤血球内Bile Pigment Precursorsと赤血球内遊離Parphyrinとの関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to study the possibility of porphyrin to become bile pigment precursors, the relations between free porphyrin in erythrocytes, especially protoporphyrin, and intracorpuscular bile pigment precursors were experimentally observed. The results were as follows: 1. A part of protoporphyrin which increased was observed to change quickly into bile pigment precursors in the erythrocytes of a phlebotomized anemic or phenylhydrazine HC1 administered rabbits where reticulocytosis occurred. 2. This transformation of protoporphyrin into bile pigment precursors were also observed in preserving canine erythrocytes where reticulocytosis was caused by phlebotomies. 3. Judging from the variations of intracorpuscular easily split off blood iron, it seemed appropriate to consider that this transformation occurred after the formation of hems or hemoglobin. In the above experiment, however, of preserving erythrocytes of a phlebotomized anemic dog, the plainly direct transformation of protoporphyrin into bile pigment precursors were also observed. 4. In preserving canine erythrocytes with or without the addition of ascorbic acid, the increase of protoporphyrin and of bile pigment precursors were also observed. However, it is difficult to account for the relations betwaen these two; the increase of bile pigment precursors may be ascribable to the breakdown of hemoglobin. 5. Intracorpuscular free coproporphyrin was obsarvei to increase in those erythrocytes after phlebotomies. phenylhydrazine HC1 aiministratioa, or preservation with the addition of ascorbic acid. This increase may more properly be ascribed to protoporphyrin in the formation process of hemoglobin than to bile pigment precursors. On the other hand, free uroporphyrin in erythrocytes did not show any significant variations. 6. Protoporphyrin mixed with chloroform extract did not hinder the microquantitative analysis of bile pigment precursors by fluorescence. en-copyright= kn-copyright= en-aut-name=NakagawaShoso en-aut-sei=Nakagawa en-aut-mei=Shoso kn-aut-name=中川昌壮 kn-aut-sei=中川 kn-aut-mei=昌壮 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1695 end-page=1709 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Bile Pigment Precursors in Erythrocytes Part 1. Micro-quantitative Analysis of Bile Pigment Precursors in Erythrocytes and its Alteration in Various Experimental Conditions kn-title=赤血球内Bile Pigment Precursorsに関する研究 第1編 赤血球内Bile Pigment Precursorsの微量定量法の検討及び実験的考察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The method of micro-quantitative analysis of bile pigment precursors in erythrocytes was studied and various experimental observations were made for the elucidation of its physiological significance. The following results were obtained: 1. Studies of the fluorescent micro-quantitative analysis made it clear that bile pigment precursors in erythrocytes can be determined in the 0.1-5.0μg/ml biliverdin chloroform solution. Observing its absorption spectrum and fluorescent spectral characteristics, it was also made clear that all the bile pigment precursors were determined by the fluorescence of choleterin zincic complex salt. 2. Gardikas' method of extracting intracorpuscular bile pigment precursors under an anaerobic condition without adding ascorbic acid proved to be better than that of R. Lemberg of extracting by adding ascorbic acid under an aerobic condition. 3. Among normal erythrocytes of various animals were found no significant specific differences, the amount of bile pigment precursors being about 15μg/Hb. 4. When dog's erythrocytes were iucubated at 37℃. after the addition of ascorbic acid, bile pigment precursors in them attained to a remarkably great amount within several hours. This is considered to have resulted from the action of ascorbic acid in choleglobin formation in erythrocytes. 5. 4 hours after phenylhydrazine HCl was administered to a rabbit, the amount of bile pigment precursors in erythrocytes in circulating blood began to increase and attained to its maximum in 4-48 hours. The amount of easily split off blood iron also increased in parallel with it. 6. When canine blood was taken in A.C.D. solution and kept at 4℃., the amount of bile pigment precursors in erythrocytes gradually increased with the course of time, showing a sudden increase after 4 weeks. The amount of easily split off blood iron showed a similar variations. 7. In the erythrocytes of a phlebotomized anemic rabbit, the amount of bile pigment precursors decreased at the same time as reticulocytes showed a remarkable increase. The amount of easily split off blood iron showed a similar tendency of decrease. 8. From the above results the following conclusions were drawn. Bile pigment precursors which are usually observed in normal erythrocytes are increased by chemicals such as ascorbic acid and phenylhydrazine HCl, or by preservation, while in the case of anemia by phlebotomies where immature erythrocytes increase, the amount of bile pigment precursors decreases. Consequently, bile pigment precursors in erythrocytes physiologically increase with deterioration. en-copyright= kn-copyright= en-aut-name=NakagawaShoso en-aut-sei=Nakagawa en-aut-mei=Shoso kn-aut-name=中川昌壮 kn-aut-sei=中川 kn-aut-mei=昌壮 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=801 end-page=810 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Epidemiological Observations on Infectious Hepatitis Prevailed in Okayama Prefecture kn-title=岡山県における流行性肝炎の流行に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=6246 infectious hepatitis cases treated at 25 hospitals located in Okayama Prefecture during the last six years, 1952 to 1957, were studied mainly from the epidemiological point of view, and the following results were obtained. 1) Infectious hepatitis has been prevailed all over the prefecture since the initial epidemic in 1951. As the mode of epidemic became protracted, chronic and abortive forms were prone to increase in number. The ratio of total patients to infectious hepatitis cases was 1.27 per cent. 2) Extensive infections among villagers were noted in 73 hamlets, and it was presumed that the epidemic has been prevailed over the whole prefecture taking a hamlet, village or a town as unit. Infections among family were noted in 62 families, however, fnrther detailed study in the epidemic areas might show the higher morbidity. It was not certain whether these infections were entirely family or simultaneous infections. 3) As to seasonal occurence, considerable number of cases had onset of the disease during the period of early summer to early fall. 4) As to age, it has ranged mostly from the second to third decade, rather many in children but not rare in the aged. As to sex, predominant in males in general, but considerable differences were seen among hospitals and times. No definite relationship was noted between the epidemc and sex. 5) Throughout the last six years there have been 38.7 per cent of chronic hepatitis cases. In 41.3 per cent of the whole patients presented jaundice in their clinical courses. The fact that the longer the period of the epidemic the more increase increase in anicteric cases was noted. 6) Two year's follow-up studies after the epidemic, showed 209 of relapsed cases in whom 36.4 per cent were icteric. 7) 110 cases has jaundice, which was thought to be infectious hepatitis, in the past. Some of them were presumably reinfections or superinfections but definite conclusion could not be made. 8) 20 cases of fulminant hepatitis, malignant type of infectious hepatitis, and 6 cases of protracted form were studied. 22 cases of them were fatal. Such severe hepatitis patients were seen mainly in males of the second and third decades. 9) 61 cases (0.98%) developed postnecrotic cirrhosis, and 10 cases of them were fatal. 10) Serum hepatitis was noted in 1.6 per cent of the whole patients seen in Medical Services at 18 hospitals in Okayama Prefecture during the last six years, 1952 to 1957. No definite correlation between the epidemic of infectious hepatitis and outbreak of serum hepatitis was noted. en-copyright= kn-copyright= en-aut-name=KosakaKiyowo en-aut-sei=Kosaka en-aut-mei=Kiyowo kn-aut-name=小坂淳夫 kn-aut-sei=小坂 kn-aut-mei=淳夫 aut-affil-num=1 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name=長島秀夫 kn-aut-sei=長島 kn-aut-mei=秀夫 aut-affil-num=2 ORCID= en-aut-name=ShimadaYoshihiro en-aut-sei=Shimada en-aut-mei=Yoshihiro kn-aut-name=島田宜浩 kn-aut-sei=島田 kn-aut-mei=宜浩 aut-affil-num=3 ORCID= en-aut-name=YamabukiTakahiro en-aut-sei=Yamabuki en-aut-mei=Takahiro kn-aut-name=山吹隆寛 kn-aut-sei=山吹 kn-aut-mei=隆寛 aut-affil-num=4 ORCID= en-aut-name=KawaguchiMasamitsu en-aut-sei=Kawaguchi en-aut-mei=Masamitsu kn-aut-name=川口正光 kn-aut-sei=川口 kn-aut-mei=正光 aut-affil-num=5 ORCID= en-aut-name=YamamotoShigeru en-aut-sei=Yamamoto en-aut-mei=Shigeru kn-aut-name=山本繁 kn-aut-sei=山本 kn-aut-mei=繁 aut-affil-num=6 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name=太田康幸 kn-aut-sei=太田 kn-aut-mei=康幸 aut-affil-num=7 ORCID= en-aut-name=UjikeMutsuo en-aut-sei=Ujike en-aut-mei=Mutsuo kn-aut-name=氏家睦夫 kn-aut-sei=氏家 kn-aut-mei=睦夫 aut-affil-num=8 ORCID= en-aut-name=KusakaYoshiro en-aut-sei=Kusaka en-aut-mei=Yoshiro kn-aut-name=草加芳郎 kn-aut-sei=草加 kn-aut-mei=芳郎 aut-affil-num=9 ORCID= en-aut-name=MitsudaToshihiro en-aut-sei=Mitsuda en-aut-mei=Toshihiro kn-aut-name=光田利弘 kn-aut-sei=光田 kn-aut-mei=利弘 aut-affil-num=10 ORCID= en-aut-name=KiharaTsuyoshi en-aut-sei=Kihara en-aut-mei=Tsuyoshi kn-aut-name=木原彊 kn-aut-sei=木原 kn-aut-mei=彊 aut-affil-num=11 ORCID= en-aut-name=KondoTadasuke en-aut-sei=Kondo en-aut-mei=Tadasuke kn-aut-name=近藤忠亮 kn-aut-sei=近藤 kn-aut-mei=忠亮 aut-affil-num=12 ORCID= en-aut-name=HaraokaSyoichi en-aut-sei=Haraoka en-aut-mei=Syoichi kn-aut-name=原岡昭一 kn-aut-sei=原岡 kn-aut-mei=昭一 aut-affil-num=13 ORCID= en-aut-name=AmiokaTadashi en-aut-sei=Amioka en-aut-mei=Tadashi kn-aut-name=網岡忠 kn-aut-sei=網岡 kn-aut-mei=忠 aut-affil-num=14 ORCID= en-aut-name=IshimitsuTetsusaburo en-aut-sei=Ishimitsu en-aut-mei=Tetsusaburo kn-aut-name=石光鉄三郎 kn-aut-sei=石光 kn-aut-mei=鉄三郎 aut-affil-num=15 ORCID= en-aut-name=KonoHiroya en-aut-sei=Kono en-aut-mei=Hiroya kn-aut-name=河野浩哉 kn-aut-sei=河野 kn-aut-mei=浩哉 aut-affil-num=16 ORCID= en-aut-name=MitsumotoToshiro en-aut-sei=Mitsumoto en-aut-mei=Toshiro kn-aut-name=光本敏郎 kn-aut-sei=光本 kn-aut-mei=敏郎 aut-affil-num=17 ORCID= en-aut-name=AisakaTadakazu en-aut-sei=Aisaka en-aut-mei=Tadakazu kn-aut-name=相坂忠一 kn-aut-sei=相坂 kn-aut-mei=忠一 aut-affil-num=18 ORCID= en-aut-name=KosakaChuihiro en-aut-sei=Kosaka en-aut-mei=Chuihiro kn-aut-name=小坂忠一郎 kn-aut-sei=小坂 kn-aut-mei=忠一郎 aut-affil-num=19 ORCID= en-aut-name=MoritaniYui en-aut-sei=Moritani en-aut-mei=Yui kn-aut-name=森谷有為 kn-aut-sei=森谷 kn-aut-mei=有為 aut-affil-num=20 ORCID= en-aut-name=TabuchiHiroshi en-aut-sei=Tabuchi en-aut-mei=Hiroshi kn-aut-name=田渊博司 kn-aut-sei=田渊 kn-aut-mei=博司 aut-affil-num=21 ORCID= en-aut-name=HashimotoKyoji en-aut-sei=Hashimoto en-aut-mei=Kyoji kn-aut-name=橋本恭治 kn-aut-sei=橋本 kn-aut-mei=恭治 aut-affil-num=22 ORCID= en-aut-name=KimuraKenichi en-aut-sei=Kimura en-aut-mei=Kenichi kn-aut-name=木村健一 kn-aut-sei=木村 kn-aut-mei=健一 aut-affil-num=23 ORCID= en-aut-name=KonoHiroshi en-aut-sei=Kono en-aut-mei=Hiroshi kn-aut-name=河野宏 kn-aut-sei=河野 kn-aut-mei=宏 aut-affil-num=24 ORCID= en-aut-name=TamaoHiroyasu en-aut-sei=Tamao en-aut-mei=Hiroyasu kn-aut-name=玉尾博康 kn-aut-sei=玉尾 kn-aut-mei=博康 aut-affil-num=25 ORCID= en-aut-name=HiguchiYosimitsu en-aut-sei=Higuchi en-aut-mei=Yosimitsu kn-aut-name=樋口祥光 kn-aut-sei=樋口 kn-aut-mei=祥光 aut-affil-num=26 ORCID= en-aut-name=YahataKatsumi en-aut-sei=Yahata en-aut-mei=Katsumi kn-aut-name=八幡勝美 kn-aut-sei=八幡 kn-aut-mei=勝美 aut-affil-num=27 ORCID= en-aut-name=ImaiHarujiro en-aut-sei=Imai en-aut-mei=Harujiro kn-aut-name=今井春路郎 kn-aut-sei=今井 kn-aut-mei=春路郎 aut-affil-num=28 ORCID= en-aut-name=KameyamaIchiro en-aut-sei=Kameyama en-aut-mei=Ichiro kn-aut-name=亀山一郎 kn-aut-sei=亀山 kn-aut-mei=一郎 aut-affil-num=29 ORCID= en-aut-name=ArijiSumiro en-aut-sei=Ariji en-aut-mei=Sumiro kn-aut-name=有地澄郎 kn-aut-sei=有地 kn-aut-mei=澄郎 aut-affil-num=30 ORCID= en-aut-name=FujimoriYasuhiko en-aut-sei=Fujimori en-aut-mei=Yasuhiko kn-aut-name=藤森恭彦 kn-aut-sei=藤森 kn-aut-mei=恭彦 aut-affil-num=31 ORCID= en-aut-name=NakagawaSyoso en-aut-sei=Nakagawa en-aut-mei=Syoso kn-aut-name=中川昌壮 kn-aut-sei=中川 kn-aut-mei=昌壮 aut-affil-num=32 ORCID= en-aut-name=HiranoYutaka en-aut-sei=Hirano en-aut-mei=Yutaka kn-aut-name=平野寛 kn-aut-sei=平野 kn-aut-mei=寛 aut-affil-num=33 ORCID= en-aut-name=KobayashiToshinari en-aut-sei=Kobayashi en-aut-mei=Toshinari kn-aut-name=小林敏成 kn-aut-sei=小林 kn-aut-mei=敏成 aut-affil-num=34 ORCID= en-aut-name=SeidoIchiro en-aut-sei=Seido en-aut-mei=Ichiro kn-aut-name=清藤一郎 kn-aut-sei=清藤 kn-aut-mei=一郎 aut-affil-num=35 ORCID= en-aut-name=TanabeIsao en-aut-sei=Tanabe en-aut-mei=Isao kn-aut-name=田辺功 kn-aut-sei=田辺 kn-aut-mei=功 aut-affil-num=36 ORCID= en-aut-name=TakedaKazuhisa en-aut-sei=Takeda en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=37 ORCID= en-aut-name=HayashiShinichiro en-aut-sei=Hayashi en-aut-mei=Shinichiro kn-aut-name=林愼一郎 kn-aut-sei=林 kn-aut-mei=愼一郎 aut-affil-num=38 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=13 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=14 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=15 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=16 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=17 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=18 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=19 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=20 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=21 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=22 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=23 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=24 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=25 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=26 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=27 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=28 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=29 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=30 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=31 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=32 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=33 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=34 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=35 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=36 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=37 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=38 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=631 end-page=635 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Measurement of Human Blood Catalase Activity and the Screening Method of Hypocatalasemia by Spectrophotometry Part 4. A simple method of measuring human blood catalase activity and the screening test for hypocatalasemia kn-title=分光光度法による人血液カタラーゼ活性の定量および低カタラーゼ血液症のスクリーニング法について 第4編 本法による活性の直接定量法と低「カ」血症のスクリーニング法 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is generally accepted that modified Euler-Josephson's method of titration gives the value of catalase activity, “Kcat” as the standard value. Whereas by the author's method taking the value of catalase activity as "k" measured, for example, at room temperature, recorded on an autorecording apparatus, it will be seen that we get the formula, Kcat=1/1.035 (100/90K+0.513) The present study has led to the following conclusions: This method is characterized by the fact that it is useful for the screening test for hypocatalasemia as well as for simultaneous measurement of the catalase activity in human blood. It is suggested that the level of the screening be fixed more appropriately at 2.4. Attempts have been made to use a portable UV-colorimeter to the screening but it seemed that this apparatus is not suitable for the purpose. This method can measure not only the activity of purified catalase but also that of a partially purified catalase. It can also be applied for the measurement of catalase activity in tissues other than blood. It is anticipated that this method can also be useful for the investigation of hypocatalasemic blood catalase from the aspect of enzyme kinetics. en-copyright= kn-copyright= en-aut-name=NakagawaYoshito en-aut-sei=Nakagawa en-aut-mei=Yoshito kn-aut-name=中川嘉人 kn-aut-sei=中川 kn-aut-mei=嘉人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=625 end-page=630 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Measurement of Human Blood Catalase Activity and the Screening Method of Hypocatalasemia by Spectrophotometry Part 3. Evaluation of UV method supplemented with basic experiments on the measurement of human blood catalase activity kn-title=分光光度法による入血液カタラーゼ活性の定量および低カタラーゼ血液症のスクリーニング法について 第3編 本法の検討と活性測定に関する基礎的実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The present communication deals with the principle of measuring and calculating the catalase activity of human blood by UV method. Under the conditions previously described, it has been clarified that the reaction of catalase-hydrogen peroxide practically follows the first order kinetics within 30-120 seconds. The velocity constant, k, seems to have no concern with the substrate concentration within the range of 0.005-0.025 mole. Catalase values, Kcat, measured under room temperature, are about 10% lower than those taken at 37℃. It has been found that measurements of the catalase activity have to be taken within 5 minutes after hemolysis en-copyright= kn-copyright= en-aut-name=NakagawaYoshito en-aut-sei=Nakagawa en-aut-mei=Yoshito kn-aut-name=中川嘉人 kn-aut-sei=中川 kn-aut-mei=嘉人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=619 end-page=623 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Measurement of Human Blood Catalase Activity and the Screening Method of Hypocatalasemia by Spectrophotometry Part 2. Measurement of human blood catalase activity by spectrophotometry with a temperature controlled cell chamber and autorecorder kn-title=分光光度計による人血液カタラーゼ活性の定量および低カタラーゼ血液症のスクリーニング法について 第2編 恒温ならびに自記記録装置を装着して正常及び低「カ」血症血液の測定 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaYoshito en-aut-sei=Nakagawa en-aut-mei=Yoshito kn-aut-name=中川嘉人 kn-aut-sei=中川 kn-aut-mei=嘉人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=613 end-page=618 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Measurement of Human Blood Catalase Activity and the Screening Method of Hypocatalasemia by Spectrophotometry Part 1. Measurement of Human Blood Catalase Activity by Spectrophotometry (with a Hitachi GPO Model) kn-title=分光々度法による人血液カタラーゼ活性の定量および低カタラーゼ血液症のスクリーニング法について 第1編 直読式分光々電光度計による正常血カタラーゼ活性の測定 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaYoshito en-aut-sei=Nakagawa en-aut-mei=Yoshito kn-aut-name=中川嘉人 kn-aut-sei=中川 kn-aut-mei=嘉人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=5-6 article-no= start-page=363 end-page=371 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on vectorcardiography Part Ⅰ. Basic studies on vectorcardiography by Kimura system with special reference to Frank system kn-title=ベクトル心電図に関する研究 第Ⅰ編 木村法ベクトル心電図の基礎的検討(とくにFrank法との対比) en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using a human torso model which had been made up with reference to normal stature of Japanese adult male and using four types of elliptical cylinder model which have different longitudinal diameter, Kimura system and Frank system were studied from the standpoint of transfer impedeance, and following results were obtained. 1) In Kimura system, elevation of transfer impedance of X and Z leads deviated to upward about 15 degrees in comparison with the latter. Nevertheless, the former's orthogonality was maintained relatively well, and have been scarcely affected by the type of elliptical cylinder. 2) In Frank system, according to narrowing of longitudinal diameter of thorax, orthogonality of X and Z leads became worse and included angles of their transfer impedance became narrow. 3) In Kimura system, the ratio of transfer impedance of X to Y leads was about 1:3 in each model, therefore, frontal plane vectorcardiogram of Kimura system could be useful for diagnosis of cases whose heart-electromotive forces change vertically. 4) Much axis deviation could not be caused by the changes of position of artificial current dipole and longitudinal diameter of the thorax. en-copyright= kn-copyright= en-aut-name=NakagawaMasahiro en-aut-sei=Nakagawa en-aut-mei=Masahiro kn-aut-name=中川雅博 kn-aut-sei=中川 kn-aut-mei=雅博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第I内科学教室 END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=9-10 article-no= start-page=915 end-page=922 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19751030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Study on Lead Systems of Vectorcardiogram with Canine Homogenious Torso Model kn-title=犬のベクトル心電図誘導法の基礎的検討（伝達インピーダンスの観点から） en-subtitle= kn-subtitle= en-abstract= kn-abstract=The transfer impedance determined on Frank's lead system and McFee, Parungao's lead system using canine torso model was studied and following results were obtained. A simplyfied canine torso model was made, which was a cylinderic type imitated faithfully the transverse section in the fifth intercostal space of the canine. The canine which was used as a model has a body weight of 16.2kg. Its torso dimensions were left to right of 14.0cm, front to back of 19.0cm and height of 55.0cm. Its form was an oval on the whole shape with more gently curved surface on the front. Heart center on the dog determined by the X-ray located on the position which was 0.75cm to the left, 2.9cm to the front from the body center in the fifth intercostal soace. The definite dipole was placed on the heart center of the torso filled with 0.1% NaCl solution. Electrode position on the torso surface is defined by two quantities; levels (number 1 throngh 10) and angles in the transverse plane. The levels were separated each other at a distance of 3cm. Thus determined level 6 correspond to heart center level of the canine. The angles were taken each 5 or 10 around the cylinder whose plane passed precisely through the center of the body. Thus, potentials were determined and image surface was drawned on the loops. Image loops were oval and located on left anteriorly and slightly inferiorly from the heart center. As a result, canine image loop was found to be clearly different from the shape of the human's one which has a shape of a pear projecting slightly to the back. Then, normality and orthogonality were examined on the torso with the Frank's orthogonal lead system for human and with the McFee, Parungao's axial lead system for dog resulting the latter to be better than the former. en-copyright= kn-copyright= en-aut-name=FujitaTakashi en-aut-sei=Fujita en-aut-mei=Takashi kn-aut-name=藤田興 kn-aut-sei=藤田 kn-aut-mei=興 aut-affil-num=1 ORCID= en-aut-name=SaitoDaiji en-aut-sei=Saito en-aut-mei=Daiji kn-aut-name=斉藤大治 kn-aut-sei=斉藤 kn-aut-mei=大治 aut-affil-num=2 ORCID= en-aut-name=InoueKatsutoshi en-aut-sei=Inoue en-aut-mei=Katsutoshi kn-aut-name=井上勝稔 kn-aut-sei=井上 kn-aut-mei=勝稔 aut-affil-num=3 ORCID= en-aut-name=NakagawaMasahiro en-aut-sei=Nakagawa en-aut-mei=Masahiro kn-aut-name=中川雅博 kn-aut-sei=中川 kn-aut-mei=雅博 aut-affil-num=4 ORCID= en-aut-name=HiranoKazuhiro en-aut-sei=Hirano en-aut-mei=Kazuhiro kn-aut-name=平野和博 kn-aut-sei=平野 kn-aut-mei=和博 aut-affil-num=5 ORCID= en-aut-name=UedaMinoru en-aut-sei=Ueda en-aut-mei=Minoru kn-aut-name=上田稔 kn-aut-sei=上田 kn-aut-mei=稔 aut-affil-num=6 ORCID= en-aut-name=HisamatsuMitsuo en-aut-sei=Hisamatsu en-aut-mei=Mitsuo kn-aut-name=久松三生 kn-aut-sei=久松 kn-aut-mei=三生 aut-affil-num=7 ORCID= en-aut-name=HaraokaShoichi en-aut-sei=Haraoka en-aut-mei=Shoichi kn-aut-name=原岡昭一 kn-aut-sei=原岡 kn-aut-mei=昭一 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院中央検査部 END start-ver=1.4 cd-journal=joma no-vol=90 cd-vols= no-issue=11-12 article-no= start-page=1399 end-page=1405 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19781230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of electrode position (I,E,C,A,M) on Frank lead system of vectorcariography kn-title=ベクトル心電図（Frank法）の胸部誘導子（I,E,C,A,M）の位置に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The transverse level of electrodes, A, C, E, I and M in Frank system vectorcardiography is important, since it affects the accuracy of the vectorcardiogram. 1. Using a Japanese male torso mode, the effects of shift in electrode position from the fifth to the fourth intercostal space level on lead vector were studied, and results were as follows. The magnitude of elad vector decreased in lead Z and increased in lead Y with moving all electrodes downward from the level of artificial dipole. 2. The transverse level of the center of heart vector was determined in healthy Japanese males in supine position using three-step technique. Following results were obtained. The level was upper than the fifth intercostal space, and in association with an increase in cardio-thoracic ratio, it shifted upward from the fifth intercostal space. en-copyright= kn-copyright= en-aut-name=HaraokaShoichi en-aut-sei=Haraoka en-aut-mei=Shoichi kn-aut-name=原岡昭一 kn-aut-sei=原岡 kn-aut-mei=昭一 aut-affil-num=1 ORCID= en-aut-name=NakagawaMasahiro en-aut-sei=Nakagawa en-aut-mei=Masahiro kn-aut-name=中川雅博 kn-aut-sei=中川 kn-aut-mei=雅博 aut-affil-num=2 ORCID= en-aut-name=SaitoDaiji en-aut-sei=Saito en-aut-mei=Daiji kn-aut-name=斉藤大治 kn-aut-sei=斉藤 kn-aut-mei=大治 aut-affil-num=3 ORCID= en-aut-name=MiyasakaMinoru en-aut-sei=Miyasaka en-aut-mei=Minoru kn-aut-name=宮阪実 kn-aut-sei=宮阪 kn-aut-mei=実 aut-affil-num=4 ORCID= en-aut-name=KawasakiTomoko en-aut-sei=Kawasaki en-aut-mei=Tomoko kn-aut-name=川崎智子 kn-aut-sei=川崎 kn-aut-mei=智子 aut-affil-num=5 ORCID= en-aut-name=IkenagaToyotake en-aut-sei=Ikenaga en-aut-mei=Toyotake kn-aut-name=生長豊健 kn-aut-sei=生長 kn-aut-mei=豊健 aut-affil-num=6 ORCID= en-aut-name=YoshiokaNobuhiko en-aut-sei=Yoshioka en-aut-mei=Nobuhiko kn-aut-name=吉岡信彦 kn-aut-sei=吉岡 kn-aut-mei=信彦 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=9-10 article-no= start-page=1267 end-page=1283 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19771030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on vectorcardiography Part II. Vectrocardiographic studies on left axis deviation by comparison of the Frank lead system with Kimura lead system kn-title=ベクトル心電図に関する研究 第II編 Frank法と木村法の対比による左軸偏位例の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To elucidate the cause of high degree left axis deviation (LAD) revealed in ECG, 86 subjects in total, 60 males and 26 females, whose ECG indicated a QRS-interval less than 0.12 sec and a mean QRS electrical axis in-between -30℃ to -90℃, were selected for analysis of VCG. Lead systems of VCG introduced by Frank and Kimura were employed for this study. As described in preceeding paper, the Kimura lead system is considered to be useful for the analysis of LAD since in experiments of human torso models, this system was demonstrated to have a value in use to detect vertical changes of heart-electromotive-forces. Then, by the analysis of configurations of QRS-loop in the frontal plane of VCG, they were divided as follows; in the Frank lead system: 6 types, F-1 to F-6, in the Kimura lead system: 5 types, CCW(L), CCW(R), CCW(R'), CW(L), CW(R). In the latter, they were furthermore sub-divided into 3 types, a, b, and c, according to the length of the vertical component of QRS-loop. (See the text, Fig. 1 and Fig. 2) Results were as follows: 1) F-4 and F-5 types which are considered to represent the left anterior hemiblock (LAH) in the Frank lead system showed CCW(L) type, left superiorly deviated QRS-loop with elongation, in the Kimura lead system. 2) The S(I) S(II) S(III) type in the ECG was determined to corespond to F-1, F-2, or F-6 type in the Frank lead system, and to CCW(R), CCW(R'), or CW(R) type in the Kimura lead system in which the right component of QRS-loop was dominant. 3) Several cases classified as F-3 or F-6 type in the Frank lead system which could not be defined as LAH were determined as CCW(L)a type in the Kimura lead system suggesting the LAH. 4) There could not be found correlations between Rosenbaum's diagnostic criteria for LAH and these VCG configurations. Therefore, it was suggested by the present study that the analysis of VCG configurations are useful for the diagnosis of LAH. 5) VCGs of ostium primum atrial septal defect were classified as F-6 and CCW(R') types whose configurations of QRS-loop were different from the one of LAH. 6) Several cases of pulmonary emphysema associating with LAD were disclosed to be classified as F-4 and CCW(L)a types suggesting the LAH. en-copyright= kn-copyright= en-aut-name=NakagawaMasahiro en-aut-sei=Nakagawa en-aut-mei=Masahiro kn-aut-name=中川雅博 kn-aut-sei=中川 kn-aut-mei=雅博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=7-8 article-no= start-page=687 end-page=695 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Radiation Therapy of Angioblastoma (Nakagawa) of the Skin kn-title=血管芽細胞腫(中川)の放射線治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Percent depth dose curves of Lineac electron beam and Dermopan soft X-ray, which are used for radiation therapy of surface tumors, were studied in 2 patients with angioblastoma (Nakagawa) who had been followed up for a long time after radiation therapy. The results are discussed with a review of the literature. Lineac electron beam therapy at low doses that do not cause remote complications appeared to be useful in the treatment of surface tumors selected after careful consideration of the indications. en-copyright= kn-copyright= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name=平木祥夫 kn-aut-sei=平木 kn-aut-mei=祥夫 aut-affil-num=1 ORCID= en-aut-name=MorimotoSetsuo en-aut-sei=Morimoto en-aut-mei=Setsuo kn-aut-name=森本節夫 kn-aut-sei=森本 kn-aut-mei=節夫 aut-affil-num=2 ORCID= en-aut-name=SatohNobuo en-aut-sei=Satoh en-aut-mei=Nobuo kn-aut-name=佐藤伸夫 kn-aut-sei=佐藤 kn-aut-mei=伸夫 aut-affil-num=3 ORCID= en-aut-name=YamamotoYoshio en-aut-sei=Yamamoto en-aut-mei=Yoshio kn-aut-name=山本淑雄 kn-aut-sei=山本 kn-aut-mei=淑雄 aut-affil-num=4 ORCID= en-aut-name=ShirakamiToshiaki en-aut-sei=Shirakami en-aut-mei=Toshiaki kn-aut-name=白神敏明 kn-aut-sei=白神 kn-aut-mei=敏明 aut-affil-num=5 ORCID= en-aut-name=JojaIkuo en-aut-sei=Joja en-aut-mei=Ikuo kn-aut-name=上者郁夫 kn-aut-sei=上者 kn-aut-mei=郁夫 aut-affil-num=6 ORCID= en-aut-name=KimotoShin en-aut-sei=Kimoto en-aut-mei=Shin kn-aut-name=木本真 kn-aut-sei=木本 kn-aut-mei=真 aut-affil-num=7 ORCID= en-aut-name=HashimotoKeiji en-aut-sei=Hashimoto en-aut-mei=Keiji kn-aut-name=橋本啓二 kn-aut-sei=橋本 kn-aut-mei=啓二 aut-affil-num=8 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=9 ORCID= en-aut-name=NakagiriYoshitada en-aut-sei=Nakagiri en-aut-mei=Yoshitada kn-aut-name=中桐義忠 kn-aut-sei=中桐 kn-aut-mei=義忠 aut-affil-num=10 ORCID= en-aut-name=ArakawaKenzo en-aut-sei=Arakawa en-aut-mei=Kenzo kn-aut-name=荒川謙三 kn-aut-sei=荒川 kn-aut-mei=謙三 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院中央放射線部 affil-num=11 en-affil= kn-affil=岡山大学医学部皮膚科学教室 en-keyword=血管芽細胞腫(中川) kn-keyword=血管芽細胞腫(中川) en-keyword=放射線治療 kn-keyword=放射線治療 en-keyword=電子線治療 kn-keyword=電子線治療 en-keyword=Dermopan 軟 X線治療 kn-keyword=Dermopan 軟 X線治療 END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=50 end-page=57 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=IgE受容体を介する刺激に対する好塩基球の形態的変化の顕微鏡的観察. 抗原と抗IgE刺激の特徴とその相違点 kn-title=Microscopic observation on morphological changes of basophils induced by cross-linking of IgE receptors en-subtitle= kn-subtitle= en-abstract=抗原および抗IgE刺激時の好塩基球の形態変化の特徴について,ヒスタミン遊離との関連のもとに,顕微鏡下に経時的に観察した｡1.抗原刺激時のヒスタミン遊離は,15分間のincubationのいずれの時期においても,抗IgE刺激に比べ有意に多く,incubation時間3分と9分では両者間に有意の差が見られた｡2.抗原刺激時の好塩基球数の減少も抗IgE刺激に比べより高度であった｡3.運動亢進により洋梨型を示す抗塩基球では,長径/短径比の増大が見られた｡この長径/短径比の増大を示す好塩基球は,抗原刺激時に抗IgE刺激に比べより高頻度に見られ,特にincubation6分と15分では両者間に有意の差が見られた｡4.膨化型を示す好塩基球ではその平均直径の増大が見られるが,この平均直径の増大については,抗原と抗lgE刺激との間に差は見られなかった｡以上の結果より,抗原刺激では,好塩基球のactivate,運動亢進へ の過程が抗IgE刺激時と比べより高度であるが,膨化への過程には両者間に差が見られないことが示唆された｡ kn-abstract=Differences in morphological changes of basophils between antigen and anti-IgE　stimulation were examined in atopic subjects in relation to histamine release.　1. Antigen-　induced release of histamine was remarkably more rapid and larger at any incubation time than the release by anit-IgE, and a significant difference was found at 3 to 9 min. 2. Decrease in number of basophils induced by antigen was significantly higher for 12 to 15 min incubation time than that by anti-IgE. 3. Morphological changes of basophils representing increased motility such as an increased ratio of short to long axis diameter (L/S ratio) and an increased incidence of basophils with localized granules (LG) were more often observed in antigen stimulation compared with anti-IgE, and the L/S ratio of the cells was significantly more increased in antigen stimulation at 6 and 15 min. 4. There was no difference in morphological changes of basophils showimg swollen type (degranulation) such as an increased mean diameter (MD) of the cells between antigen and anti-IgE. These results suggest that antigen activates basophils and induces increased motility more strongly than anti-IgE, but the action on degranulation was not different between the two agents. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=NakagawaSaburo en-aut-sei=Nakagawa en-aut-mei=Saburo kn-aut-name=中川三郎 kn-aut-sei=中川 kn-aut-mei=三郎 aut-affil-num=2 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=3 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=Histamine release (ヒスタミン遊離) kn-keyword=Histamine release (ヒスタミン遊離) en-keyword=Morphological changes of basophils (好塩基球の形態的変化) kn-keyword=Morphological changes of basophils (好塩基球の形態的変化) en-keyword=Antigen (抗原) kn-keyword=Antigen (抗原) en-keyword=Anti-IgE (抗IgE) kn-keyword=Anti-IgE (抗IgE) en-keyword=IgE receptors (IgE受容体) kn-keyword=IgE receptors (IgE受容体) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=43 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=抗原および Ca ionophore A23187 刺激時におけるアトピー型気管支喘息末梢血好塩基球の運動能 kn-title=Difference in motility of basophilic, granulocytes from atopic subjects following antigen- and Ca inophore A23187-stimulation en-subtitle= kn-subtitle= en-abstract=アトピー型気管支喘息末梢血好塩基球を用い,抗原および Ca ionophore A23187 刺激時のヒスタミン遊離およびその形態的変化について比較検討した｡1.抗原刺激時には, Ca ionophore A23187 刺激時に比べ,好塩基球からのヒスタミン遊離および好塩基球数の減少の程度は,より急激でかつ高度であった｡2.好塩基球の形態的変化,すなわち,長経/短経比の増大,限局性顆粒あるいは偽足を有する好塩基球の出現頻度の増加などの運動能の亢進を示唆する好塩基球の形態的変化は, Ca ionophore A23187 に比べ抗原刺激時により高度であった｡一方,平均直径の増大,5個以上の空砲を有する好塩基球の出現頻度の増加などの,むしろ膨化傾向を示唆する好塩基球の形態的変化は,抗原刺激時に比べ, Co ionophore A23187 刺激時により高度であった｡これらの結果より,抗原刺激によるIgE受容体のbridgingが,好塩基球を活性化し,運動能の亢進をひき起こすものと判断された。 kn-abstract=We examined histamine release and morphological changes in basophilic granulocytes from atopic subjects, in response to stimulation with antigen and Ca ionophore A23187. 1. Histamine release and a reduction in the rumber of basophils were more rapid and greater in extent at an early stage of antigen stimulation compared with Ca ionophore A23187 stimulation. 2. Morphological changes in basophils, represented by increased motility, in terms of an increased ratio of short to long axis diameter (L/S ratio), as well as the increased frequency of basophils with localized granules and those with pseudopods, were more often observed antigen stimulation than with Ca ionophore A23187 stimulation. In contrast, morphogical changes in which basophils appeared swollen, showing an increased mean cell diameter and an increased frequency of cells with 5 vacuoles or more were more predominant with Ca ionophore A23187 than with antigen stimulation. The results obtained here show that bridging of IgE receptors is essential to activate basophils and induce increased motility in these cells. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=NakagawaSaburo en-aut-sei=Nakagawa en-aut-mei=Saburo kn-aut-name=中川二郎 kn-aut-sei=中川 kn-aut-mei=二郎 aut-affil-num=7 ORCID= en-aut-name=SodaRyo en-aut-sei=Soda en-aut-mei=Ryo kn-aut-name=宗田良 kn-aut-sei=宗田 kn-aut-mei=良 aut-affil-num=8 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=9 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=6 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=histamine release (ヒスタミン遊離) kn-keyword=histamine release (ヒスタミン遊離) en-keyword=increased basophil motility (好塩基球の運動能の亢進) kn-keyword=increased basophil motility (好塩基球の運動能の亢進) en-keyword=bridging of IgE receptors (LgE 受容体) kn-keyword=bridging of IgE receptors (LgE 受容体) en-keyword=antigen (抗原) kn-keyword=antigen (抗原) en-keyword=Ca ionophore A23187 kn-keyword=Ca ionophore A23187 END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=37 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influence of the Bone for Electron-beam Therapy kn-title=電子線治療における骨の線量分布に対する影響に関する検討 en-subtitle= kn-subtitle= en-abstract=The Electron-beam therapy is often used for the treatment to malignant tumors on the surface or its neighborhood of the body. An electron-beam has the range depended on its energy, and its dose is rapidly decreased at the points beyond the range. This property is available to irradiating a tumor with leaving the critical organs unexposed. However, we should take notice that the dose-distributions are disordered if materials of various densities are in the irradiation field. In this paper, we examined how the dose-distribution are disordered by using the phantom made from human bones of various volumes. As a result, the peculiar disorders of the dose-distribution due to the difference of the bone width were found at the back and edge of a bone. Moreover, the dose at the edge of a bone was decreased, but the dose at the side of a bone was rapidly increased in the distance position from the bone. It is necessary to take account of that the above peculiar phenomenon affect the total dose for the treatment when bones exist near the target volume in the irradiation field. kn-abstract=電子線治療は,体表面またはその近傍に発生する悪性腫瘍の治療にしばしば用いられる治療法である｡電子線はエネルギーに対応した飛程を持っており,飛程を越えると急激に線量は減少する。この性質は腫瘍に一定の線量を照射し,腫瘍後方に存在する決定臓器を保護することができるので,病巣を選択的 に治療するのに好都合である｡しかし,照射野内に人体軌部組織より密度の違う物質が存在する場合,散乱,吸収の影響が大きく,電子線線量分布は乱れたものとなる｡今回,人体内にある骨を想定してVolumeの違う骨Phantomを使 用して影響を調べたところ,骨幅によって骨後方および断端に線量の乱れが生じることがわかった｡すなわち,骨の中央ではある程度後方に距離が離れると,線量は大きく減少する現象が見られた。また,横方向の線量分布は骨断端近くで一旦線量の減少が見られ,断端を離れると急激に増加する｡したがって,実際の臨床において,Target Volume近くに骨が存在する場合は総線量の決定に際して注意が必要である｡ en-copyright= kn-copyright= en-aut-name=NakagiriYoshitada en-aut-sei=Nakagiri en-aut-mei=Yoshitada kn-aut-name=中桐義忠 kn-aut-sei=中桐 kn-aut-mei=義忠 aut-affil-num=1 ORCID= en-aut-name=InamuraKeiji en-aut-sei=Inamura en-aut-mei=Keiji kn-aut-name=稲村圭司 kn-aut-sei=稲村 kn-aut-mei=圭司 aut-affil-num=2 ORCID= en-aut-name=TaharaSeiji en-aut-sei=Tahara en-aut-mei=Seiji kn-aut-name=田原誠司 kn-aut-sei=田原 kn-aut-mei=誠司 aut-affil-num=3 ORCID= en-aut-name=UnoHirofumi en-aut-sei=Uno en-aut-mei=Hirofumi kn-aut-name=宇野弘文 kn-aut-sei=宇野 kn-aut-mei=弘文 aut-affil-num=4 ORCID= en-aut-name=AzumaYoshiharu en-aut-sei=Azuma en-aut-mei=Yoshiharu kn-aut-name=東義晴 kn-aut-sei=東 kn-aut-mei=義晴 aut-affil-num=5 ORCID= en-aut-name=SibuyaKoichi en-aut-sei=Sibuya en-aut-mei=Koichi kn-aut-name=渋谷光一 kn-aut-sei=渋谷 kn-aut-mei=光一 aut-affil-num=6 ORCID= en-aut-name=GotoSachiko en-aut-sei=Goto en-aut-mei=Sachiko kn-aut-name=後藤佐知子 kn-aut-sei=後藤 kn-aut-mei=佐知子 aut-affil-num=7 ORCID= en-aut-name=MaruyamaToshinori en-aut-sei=Maruyama en-aut-mei=Toshinori kn-aut-name=丸山敏則 kn-aut-sei=丸山 kn-aut-mei=敏則 aut-affil-num=8 ORCID= en-aut-name=MoriokaYasuki en-aut-sei=Morioka en-aut-mei=Yasuki kn-aut-name=森岡泰樹 kn-aut-sei=森岡 kn-aut-mei=泰樹 aut-affil-num=9 ORCID= en-aut-name=SakaeKatsuyosi en-aut-sei=Sakae en-aut-mei=Katsuyosi kn-aut-name=栄勝美 kn-aut-sei=栄 kn-aut-mei=勝美 aut-affil-num=10 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川富夫 kn-aut-sei=中川 kn-aut-mei=富夫 aut-affil-num=11 ORCID= en-aut-name=TakemotoMitsuhiro en-aut-sei=Takemoto en-aut-mei=Mitsuhiro kn-aut-name=武本充広 kn-aut-sei=武本 kn-aut-mei=充広 aut-affil-num=12 ORCID= en-aut-name=SugitaKatsuhiko en-aut-sei=Sugita en-aut-mei=Katsuhiko kn-aut-name=杉田勝彦 kn-aut-sei=杉田 kn-aut-mei=勝彦 aut-affil-num=13 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name=平木祥夫 kn-aut-sei=平木 kn-aut-mei=祥夫 aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院中央放射線部 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院中央放射線部 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院中央放射線部 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=7 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=8 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院中央放射線部 affil-num=10 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=13 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=14 en-affil= kn-affil=岡山大学医学部放射線医学教室 en-keyword=電子線治療 (electron-beam therapy) kn-keyword=電子線治療 (electron-beam therapy) en-keyword=線量分布 (dose distribution) kn-keyword=線量分布 (dose distribution) en-keyword=不均質物質 (inhomogeneity) kn-keyword=不均質物質 (inhomogeneity) END start-ver=1.4 cd-journal=joma no-vol=121 cd-vols= no-issue=1 article-no= start-page=17 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two cases of mandibular and masticatory reconstruction with vascularized fibra bone flaps and implants kn-title=血管柄付腓骨皮弁移植とインプラントによる顎骨咬合再建の２例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Defects of the jawbone have conventionally been repaired using free bone grafts and metallic plates, but patients undergoing reconstruction using these materials experience difficulty using dentures and restoring masticatory function. The use of vascularized bone grafts, which has recently been enabled, has improved bone graft survival rates, and its combination with dental implants has enabled both morphological and functional reconstruction, leading to a higher quality of life. 　We experienced two patients with tumors of the jaw that were treated by resecting and reconstructing it using a vascularized bone graft with the cooperation of the Department of Plastic Surgery in the School of Medicine. We subsequently inserted dental implants, and the superstructure was created by the Department of Prosthetics. We report the course of these patients, who achieved sufficient jaw morphology as well as masticatory function and who are presently satisfied overall three years to three years and nine months postoperatively. en-copyright= kn-copyright= en-aut-name=TakagiShin en-aut-sei=Takagi en-aut-mei=Shin kn-aut-name=高木愼 kn-aut-sei=高木 kn-aut-mei=愼 aut-affil-num=1 ORCID= en-aut-name=MizukawaNobuyoshi en-aut-sei=Mizukawa en-aut-mei=Nobuyoshi kn-aut-name=水川展吉 kn-aut-sei=水川 kn-aut-mei=展吉 aut-affil-num=2 ORCID= en-aut-name=FukunagaJoji en-aut-sei=Fukunaga en-aut-mei=Joji kn-aut-name=福永城司 kn-aut-sei=福永 kn-aut-mei=城司 aut-affil-num=3 ORCID= en-aut-name=IshidaNobuhisa en-aut-sei=Ishida en-aut-mei=Nobuhisa kn-aut-name=石田展久 kn-aut-sei=石田 kn-aut-mei=展久 aut-affil-num=4 ORCID= en-aut-name=MaruoYukinori en-aut-sei=Maruo en-aut-mei=Yukinori kn-aut-name=丸尾幸憲 kn-aut-sei=丸尾 kn-aut-mei=幸憲 aut-affil-num=5 ORCID= en-aut-name=KannyamaManabu en-aut-sei=Kannyama en-aut-mei=Manabu kn-aut-name=完山学 kn-aut-sei=完山 kn-aut-mei=学 aut-affil-num=6 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name=木股啓裕 kn-aut-sei=木股 kn-aut-mei=啓裕 aut-affil-num=7 ORCID= en-aut-name=KoushimaIsao en-aut-sei=Koushima en-aut-mei=Isao kn-aut-name=光嶋勲 kn-aut-sei=光嶋 kn-aut-mei=勲 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬総合研究科　顎口腔再建外科学 affil-num=2 en-affil= kn-affil=岡山大学医学部歯学部附属病院　口腔外科（再建系） affil-num=3 en-affil= kn-affil=姫路市 affil-num=4 en-affil= kn-affil=岡山大学医学部歯学部附属病院　口腔外科（再建系） affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬総合研究科　咬合・有床義歯補綴学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬総合研究科　インプラント再生補綴学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬総合研究科　形成再建外科学 affil-num=8 en-affil= kn-affil=東京大学大学院医学系研究科　感覚・運動機能医学 en-keyword=血管柄付骨移植　（vascularized bone graft） kn-keyword=血管柄付骨移植　（vascularized bone graft） en-keyword=顎骨再建　（mandibular reconstruction） kn-keyword=顎骨再建　（mandibular reconstruction） en-keyword=インプラント　（implant） kn-keyword=インプラント　（implant） en-keyword=咬合再建　（occlusal reconstruction） kn-keyword=咬合再建　（occlusal reconstruction） END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=11-12 article-no= start-page=1287 end-page=1299 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Nutritional effects of branched chain amino acids and lipids in surgical stress after partial hepatectomy in the rat kn-title=高濃度分岐鎖アミノ酸を窒素源とする成分栄養剤の侵襲下における効果―肝切除ラットを用いて― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The nutritional influence of branched chain amino acids (BCAA) and lipids in surgical stress was examined after 70% hepatectomy in rats. Two types of elemental diet (ED) were given through the gastrostomy tude for 7 days. Group A : ED containing 33% BCAA and 30% lipid (medium chain triglycerides 8.5g＋soy bean oil 1.5g/300 kcal). Group B : ED containing 17% BCAA and 1.5% lipid (soy bean oil 0.49g/300 kcal). Up to the 7th postoperative day, the excretion of nitrogen into urine decreased in group A, but no change occurred in group B. Up to the 5th postoperative day, molar ratio of 3MH to creatinine in urine in group A decreased more rapidly than in group B. Plasma concentration of albumin in group A was higher than in group B on the 7th postoperative day. Fischer ratio was significantly higher in group A than in group B on the 7th postoperative day. Both plasma and muscle levels of Tyr, Met and Gln were higher in group B than in group A, Glu and Ala were lower in group B than in group A. Essential fatty acid deficiency occurred more severely in group B than in group A. While fatty livers were microscopically observed in some livers in group B, there were few fatty deposits in group A. en-copyright= kn-copyright= en-aut-name=MizutaMinoru en-aut-sei=Mizuta en-aut-mei=Minoru kn-aut-name=水田稔 kn-aut-sei=水田 kn-aut-mei=稔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=分岐鎖アミノ酸 kn-keyword=分岐鎖アミノ酸 en-keyword=脂肪乳剤 kn-keyword=脂肪乳剤 en-keyword=経腸栄養 kn-keyword=経腸栄養 en-keyword=脂肪肝 kn-keyword=脂肪肝 END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=1-2 article-no= start-page=165 end-page=176 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Magnetic resonance image database system and its clinical applications kn-title=MR 画像データベースシステムの開発とその臨床応用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A magnetic resonance (MR) image detabase system has been developed. The purpose of this paper is to present this system and its application. It consists of an image processing system and database system to handle data of clinical cases and a medical knowledge base. Using the image processing system and the database system with stored data of clinical cases, the MR image data of cases can be retrieved by diagnosis as well as ID number, patient's name, etc., and MR images can be processed. By using the database system with the medical knowledge base, differential diagnoses can be offered. en-copyright= kn-copyright= en-aut-name=NoriyasuToshiaki en-aut-sei=Noriyasu en-aut-mei=Toshiaki kn-aut-name=則安俊昭 kn-aut-sei=則安 kn-aut-mei=俊昭 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 en-keyword=MRI kn-keyword=MRI en-keyword=database kn-keyword=database en-keyword=medical image kn-keyword=medical image en-keyword=knowledge base kn-keyword=knowledge base en-keyword=PACS kn-keyword=PACS END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=4 article-no= start-page=247 end-page=255 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Oncogene mRNA in gastric cancer by in situ hybridization by using a biotin-labeled probe kn-title=Biotin 標識 probe を用いた histo in situ hydridization 法による胃癌組織における癌遺伝子 mRNA の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Expression of oncogene mRNA in gastric cancer was studied by in situ hybridization. Cancer tissues were fixed in formalin and embeded in paraffin. Then, DNA-mRNA hybridization was performed by using two biotin-labeled cDNA probes (c-myc, c-Ha ras). Oncogene mRNA was intracuelularly localized, mainly in the cytoplasm, and also found in the nucleus of partial cells. Higher concentrations of oncogene mRNA vere found in advanced cancers than in early cancers, and in metastatic positive cases of the above n2 than of n0 or n1. This suggests that the expression of oncogene mRNA is related to the malignant potency of cancer. en-copyright= kn-copyright= en-aut-name=TanakaIzuru en-aut-sei=Tanaka en-aut-mei=Izuru kn-aut-name=田中出 kn-aut-sei=田中 kn-aut-mei=出 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=histo in situ hybridization 法 kn-keyword=histo in situ hybridization 法 en-keyword=胃癌 kn-keyword=胃癌 en-keyword=癌遺伝子 kn-keyword=癌遺伝子 en-keyword=ｍRNA kn-keyword=ｍRNA END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=1-2 article-no= start-page=183 end-page=197 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study on pathogenesis and treatment of cerebral vasospasm Part 2. Effects of PGI2 analogue, thromboxane A2 synthetase inhibitor and Ca blocker on experimental delayed spasm models kn-title=脳血管攣縮の発生機序と治療に関する実験的研究 第2編 実験的遅発性脳血管攣縮に対する PGI2 analogue, Thromboxane A2 合成酵素阻害剤, Ca 拮抗剤の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of a PGI2 analogue (OP-41483), a thromboxane A2 synthetase inhibitor (OKY-046) and a Ca blocker (nifedipine) on the diameter of constricted basilar arteries and on the regional cerebral blood flow (r-CBF) in the brain stem were investigated in the cat delayed spasm model. The experiment was performed three days (72 hours) after artificial subarachnoid hemorrhage. The basilar artery was exposed transclivally, and more advanced vasospasm was produced by topical application of a lysed erythrocyte solution for 5 to 6 hours which domonstrated no more vascular dilatation even by topical application of papaverine hydrochloride (0.01mg/ml). In the delayed spasm model, the intravenous administration of neither OP-41483 (8μg/kg), OKY-046 (60mg/kg) nor nifedipine (0.003mg/kg) affected the vascular diameter. OP-41483 increased r-CBF in the brain stem in 3, and nifedipine increased it in 4 out of the 5 studied delayed spasm models, whereas OKY-046 never increased r-CBF (n=5). There was no significant difference in the amount of fatty acids including arachidonic acid between normal and constricted arteries. This study suggested that thromboxane A2 is not the major factor of cerebral vasospasm and OKY-046 might not be effective on vascular diameter or r-CBF at the late spasm stage. However, the PGI2 analogue (OP-41483) and Ca blocker (nifedipine) may be effective in increasing r-CBF even at the late spasm stage. en-copyright= kn-copyright= en-aut-name=MotokiMototsugu en-aut-sei=Motoki en-aut-mei=Mototsugu kn-aut-name=元木基嗣 kn-aut-sei=元木 kn-aut-mei=基嗣 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科教室 en-keyword=cerebral vasospasm kn-keyword=cerebral vasospasm en-keyword=thromboxane A2 kn-keyword=thromboxane A2 en-keyword=OP-41483 kn-keyword=OP-41483 en-keyword=OKY-046 kn-keyword=OKY-046 en-keyword=nifedipine kn-keyword=nifedipine END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=47 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Motility of basophilic granulocytes and histaminerelease kn-title=好塩基球の運動能とヒスタミン遊離 en-subtitle= kn-subtitle= en-abstract=Morphological changes of basophilic leucocytes from atopic asthmatics were observed in relation to histamine release after the cells were challeuged by a specific allergen, anti-IgE and Ca ionophore A 23187 . 1. Increase in motility and degranulation of basophilic granulocytes were observed after the stimulation with antigen and anti-IgE. The incidence of basophils with oriented movement was siguificantly increased at 36 min and reached the peak at 12-15 min after addition of antigen. 2. A decreased number of basophils, increased cell diameter and increased ratio of the short to long axis diameters were observed with a significant amount of histamine release after antigen and anti-IgE stimulation. 3. Compared to cell reactions to antigen and anti-IgE, Ca ionophore A 23187 stimulation showed more decreased motility and greater increase in the diameter of the cells. kn-abstract=各種刺激物質添加時の好塩基球の形態的変化―運動亢進と膨化，脱顆粒―と化学伝達物質遊離との関連を中心に若干の知見をのべた。まず，抗原刺激時には，(1)運動亢進をきたし，洋梨状を示す好塩基球と膨化，脱顆粒を示す好塩基球の2種類が観察されること，(2)アトピー型喘息の好塩基球は健康人と比べて全般的に運動が抑制されていること，(3)運動亢進の状態としては，random movementとoriented movementがあり，抗原に対応した特徴的な運動亢進はoriented movementであること，(4)運動亢進と膨化，脱顆粒は，連続した一連のものではなく，それぞれ独立した過程を持っていること，などが観察されている。また，刺激物質の種類によって，好塩基球の形態的変化や化学伝達物質遊離の状態が異なることについても報告した。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=NakagawaSaburo en-aut-sei=Nakagawa en-aut-mei=Saburo kn-aut-name=中川三郎 kn-aut-sei=中川 kn-aut-mei=三郎 aut-affil-num=6 ORCID= en-aut-name=SodaRyo en-aut-sei=Soda en-aut-mei=Ryo kn-aut-name=宗田良 kn-aut-sei=宗田 kn-aut-mei=良 aut-affil-num=7 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=8 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=9 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=好塩基球 (Basophils) kn-keyword=好塩基球 (Basophils) en-keyword=抗原 (Antigen) kn-keyword=抗原 (Antigen) en-keyword=運動亢進 (lncreased motility) kn-keyword=運動亢進 (lncreased motility) en-keyword=脱顆粒 (Degranulation) kn-keyword=脱顆粒 (Degranulation) en-keyword=ヒスタミン遊離 (Histamine release) kn-keyword=ヒスタミン遊離 (Histamine release) END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=1-2 article-no= start-page=53 end-page=63 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The role of endogenous thyrotropin releasing hormone (TRH) in maintenance of the blood pressure in awake and unrestrained rats with hemorrhagic hypotension kn-title=無麻酔･無拘束下ラットの出血性低血圧モデルにおける内因性 Thyrotropin releasing hormone (TRH) の血圧維持作用ならびにその作用部位に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A pressor effect of TRH in hemorrhagic hypotensive rats was studied. First, TRH (1mg/kg, 2mg/kg, 5mg/kg), its analogue MK771 (0.2mg/kg) and anti-TRH antibody were given intravenously. The change in the mean arterial blood pressure (MAP) was observed. After administration of TRH, MAP rose dose-dependently, and it also rose after administration of MK771. The anti-TRH antibody significantly suppressed the compensatory and reflective increase of MAP following the hemorrhage. This suggested that the endogenous TRH plays an important role in the maintenance of MAP in the hemorrhagic hypotensive state. Next, the same hypotention models were made using adreno-demedullated rats. TRH or anti-TRH antibody was given intravenously. TRH significantly increased MAP, while the anti-TRH antibody suppressed MAP. This indicates that the pressor effect of TRH is not mediated by the adrenal medulla. The endogenous TRH may play its maintenance role of blood pressure via medulla oblongata. en-copyright= kn-copyright= en-aut-name=MiyazakiMineo en-aut-sei=Miyazaki en-aut-mei=Mineo kn-aut-name=宮崎峰生 kn-aut-sei=宮崎 kn-aut-mei=峰生 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部麻酔・蘇生学教室 en-keyword=出血性低血圧 kn-keyword=出血性低血圧 en-keyword=TRH kn-keyword=TRH en-keyword=MK771 kn-keyword=MK771 en-keyword=抗 TRH 抗体 kn-keyword=抗 TRH 抗体 en-keyword=副腎髄質除去ラット kn-keyword=副腎髄質除去ラット END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=483 end-page=487 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of fibromuscular dysplasia with large cerebral aneurysm at the bifurcation of the vertebral artery to cerebellar artery associated with renal hypertensin kn-title=腎動脈性高血圧に推骨動脈―後下小脳動脈分岐部巨大動脈瘤を合併した線維筋性異形成の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 27-year-old man was admitted with symptoms of hypertension and headache. His soft palate and uvula were deviated to the right. The left side of his tongue was atrophic with fasciculation. Plasma renin activity, plasma angiotensin-I and aldosteron levels were elevated. Renal arteriography revealed membranous-stenosis with poststenotic dilation at the mid and peripheral portion of the renal artery, which was consistent with the findings of fibromus-cular dysplasia (FMD). Large aneurysm at the bifucation of the vertebral artery to postero-inferior cerebellar artery was observed by cerebral arteriography. The patient was treated with medication for renal hypertension. Percutaneous embolization of the aneurysm was performed. In conclusion, the present case had a giant cerebral aneurysm, located at a rare portion and was diagnosed before its rupture. Examination of the cerebral artery was essential in renal FMD. en-copyright= kn-copyright= en-aut-name=NakagawaHiroshi en-aut-sei=Nakagawa en-aut-mei=Hiroshi kn-aut-name=中川裕 kn-aut-sei=中川 kn-aut-mei=裕 aut-affil-num=1 ORCID= en-aut-name=KusachiShozo en-aut-sei=Kusachi en-aut-mei=Shozo kn-aut-name=草地省蔵 kn-aut-sei=草地 kn-aut-mei=省蔵 aut-affil-num=2 ORCID= en-aut-name=OkaTakefumi en-aut-sei=Oka en-aut-mei=Takefumi kn-aut-name=岡岳文 kn-aut-sei=岡 kn-aut-mei=岳文 aut-affil-num=3 ORCID= en-aut-name=UrabeNorio en-aut-sei=Urabe en-aut-mei=Norio kn-aut-name=占部則生 kn-aut-sei=占部 kn-aut-mei=則生 aut-affil-num=4 ORCID= en-aut-name=NogamiKunio en-aut-sei=Nogami en-aut-mei=Kunio kn-aut-name=野上邦夫 kn-aut-sei=野上 kn-aut-mei=邦夫 aut-affil-num=5 ORCID= en-aut-name=TakemotoMasao en-aut-sei=Takemoto en-aut-mei=Masao kn-aut-name=竹本雅雄 kn-aut-sei=竹本 kn-aut-mei=雅雄 aut-affil-num=6 ORCID= en-aut-name=MorishitaNaoya en-aut-sei=Morishita en-aut-mei=Naoya kn-aut-name=森下直也 kn-aut-sei=森下 kn-aut-mei=直也 aut-affil-num=7 ORCID= en-aut-name=InoueKimihito en-aut-sei=Inoue en-aut-mei=Kimihito kn-aut-name=井上公仁 kn-aut-sei=井上 kn-aut-mei=公仁 aut-affil-num=8 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=辻孝夫 kn-aut-sei=辻 kn-aut-mei=孝夫 aut-affil-num=9 ORCID= en-aut-name=TomitaSusumu en-aut-sei=Tomita en-aut-mei=Susumu kn-aut-name=富田亨 kn-aut-sei=富田 kn-aut-mei=亨 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一内科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部脳神経外科学教室 en-keyword=線維筋性異形成 kn-keyword=線維筋性異形成 en-keyword=脳動脈瘤 kn-keyword=脳動脈瘤 en-keyword=腎動脈性高血圧 kn-keyword=腎動脈性高血圧 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1135 end-page=1144 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Examination of ANP secretion-atrial specific granules and hemodynamics kn-title=ANP 分泌―血行動態と特殊顆粒に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify factors affecting atrial natriuretic peptide (ANP) secretion, the relationship between blood ANP level and intracardiac pressure, and that between the number of atrial specific granules (ASG) in the right atrial auricle and ANP level were investigated in 21 patients undergoing extracorporeal circulation. In the atrial loaded group, the Group TR (Tricuspid regurgitation) served as right atrial load and Group M (Mitral valve disease) as left atrial load, ANP and the number of ASG were compared with those in the control group. Accordingly, the effect of atrial load on ANP secretion and the number of ASG were investigated. Moreover, ANP and the number of ASG in the atrial myolysis group {Group A f(atrial fibrillation)} were compared with those of the sinus rhythm group to determine effect of atrio-myolysis. The ANP level showed a positive correlation with left atrial pressure (r=0.820 p<0.01) and with left ventricular end-diastolic pressure (r=0.726 p<0.01), but no correlation with right atrial pressure nor ventricular pressure. The ANP level in Group M was significantly higher than other groups, but there was no significant difference compared with Group TR. Consequently, the left atrium and rihgt atrium were considered to have different effects on ANP secretion. en-copyright= kn-copyright= en-aut-name=AsanoHirotaka en-aut-sei=Asano en-aut-mei=Hirotaka kn-aut-name=浅野弘孝 kn-aut-sei=浅野 kn-aut-mei=弘孝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=特殊顆粒 kn-keyword=特殊顆粒 en-keyword=ANP kn-keyword=ANP en-keyword=分泌調節 kn-keyword=分泌調節 en-keyword=左心房 kn-keyword=左心房 en-keyword=右心房 kn-keyword=右心房 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1117 end-page=1125 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the role of interferon gamma (IFN-γ) in the pathogenesis of bronchial asthma : Evaluation of IFN-γ production induced by Candida or mite antigen in comparison with other factors of lymphocytic function kn-title=気管支喘息における interferon-γ (IFN-γ) 産生能に関する研究 第2編 気管支喘息における IFN-γ 産生能と各種リンパ球機能との比較検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is known that IFN-γ, T-cell lymphokine, has potent effects on immunoglobulin synthesis, leukotrienes synthesis and delayed-type hypersensitivity. These factors are thought to be closely related to allergic reactions in bronchial asthma. Therefore, IFN-γ production from peripheral blood mononuclear cells induced by Candida or mite antigen was examined in asthmatics, and relations with other lymphocytic functions were studied to eluciate the role of IFN-γ. The results were as follows : (1) There was a significant correlation between IFN-γ production and Candida specific serum IgG1 antibody. (2) There was a significant correlation between IFN-γ production and lymphocyte blastgenesis induced by Candida antigen. (3) High levels of IFN-γ production were observed in asthmatics with positive late phase or delayed phase skin reaction to Candida antigen compared to asthmatics with negative late phase or delayed phase skin reaction. (4) Asthmatics with positive Candida or mite specific IgE radioallergosorbent test(RAST) showed a low level of IFN-γ production compared to asthmatics with negative IgE RAST. These results indicate that asthmatics with low IgE antibody and activated lymphocytes show high levels of IFN-γ production, and in these low IgE asthmatics, IFN-γ may play an important role in the allergic reactions of bronchial asthma. en-copyright= kn-copyright= en-aut-name=KimuraGoro en-aut-sei=Kimura en-aut-mei=Goro kn-aut-name=木村五郎 kn-aut-sei=木村 kn-aut-mei=五郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=delayed-type hypersensitivity kn-keyword=delayed-type hypersensitivity en-keyword=IFN-γ kn-keyword=IFN-γ en-keyword=IgE antibody kn-keyword=IgE antibody en-keyword=IgG1 antibody kn-keyword=IgG1 antibody END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1087 end-page=1091 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of gallbladder torsion diagnosed by abdominal CT prior to surgery kn-title=腹部 CT 検査が術前診断に有用であった胆嚢捻転症の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 77-year-old female with a chief complaint of epigastralgia was diagnosed with torsion of the gallbladder by abdominal CT prior to surgery and successfully treated by an emergency operation. Only 16 cases of gallbladder torsion including the present case have been diagnosed prior to surgery in Japan. Almost all of them were diagnosed with abdominal ultrasonography. With the growing use of CT in the evaluation of abdominal pain, preoperative diagnosis of the condition may be expedited. CT shows characteristic findings of torsion of the gallbladder such as 1) pronounded swelling of the gallbladder and circumscribed thickening of the gallbladder wall, 2) displacement of the gallbladder, and 3) volvulated gallbladder neck. We found CT to be useful for preoperative diagnosis of patients with abdominal pain. en-copyright= kn-copyright= en-aut-name=YunokiYasuhiro en-aut-sei=Yunoki en-aut-mei=Yasuhiro kn-aut-name=柚木靖弘 kn-aut-sei=柚木 kn-aut-mei=靖弘 aut-affil-num=1 ORCID= en-aut-name=MiyakeMikio en-aut-sei=Miyake en-aut-mei=Mikio kn-aut-name=三宅三喜男 kn-aut-sei=三宅 kn-aut-mei=三喜男 aut-affil-num=2 ORCID= en-aut-name=MiyagiKouji en-aut-sei=Miyagi en-aut-mei=Kouji kn-aut-name=宮木功次 kn-aut-sei=宮木 kn-aut-mei=功次 aut-affil-num=3 ORCID= en-aut-name=NakagawaHidekazu en-aut-sei=Nakagawa en-aut-mei=Hidekazu kn-aut-name=中川秀和 kn-aut-sei=中川 kn-aut-mei=秀和 aut-affil-num=4 ORCID= en-aut-name=MatsuoYouji en-aut-sei=Matsuo en-aut-mei=Youji kn-aut-name=松尾洋二 kn-aut-sei=松尾 kn-aut-mei=洋二 aut-affil-num=5 ORCID= en-aut-name=NakagouJitsuo en-aut-sei=Nakagou en-aut-mei=Jitsuo kn-aut-name=中郷実雄 kn-aut-sei=中郷 kn-aut-mei=実雄 aut-affil-num=6 ORCID= en-aut-name=LiuMiao en-aut-sei=Liu en-aut-mei=Miao kn-aut-name=劉淼 kn-aut-sei=劉 kn-aut-mei=淼 aut-affil-num=7 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=8 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=玉野三井病院外科 affil-num=2 en-affil= kn-affil=玉野三井病院外科 affil-num=3 en-affil= kn-affil=玉野三井病院外科 affil-num=4 en-affil= kn-affil=玉野三井病院外科 affil-num=5 en-affil= kn-affil=玉野三井病院外科 affil-num=6 en-affil= kn-affil=玉野三井病院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第一病理学教室 affil-num=8 en-affil= kn-affil=中国電力株式会社中電病院外科 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=胆嚢捻転症 kn-keyword=胆嚢捻転症 en-keyword=術前診断 kn-keyword=術前診断 en-keyword=腹部 CT 検査 kn-keyword=腹部 CT 検査 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=187 end-page=194 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An expert system for valvular heart disease using MRI and its clinical applications kn-title=心臓弁膜症のMR画像診断支援システムの開発とその臨床応用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=MRI is a valuable tool for diagnosing heart disease today. The cardiac blood flow is determined by an MRI image analysis and expert system. Image data are taken by a TV camera and digitalized. After gray level thresholding and region segmentation, the boundary of the regurgitant flow region is precisely extracted. Using this expert system, a doctor can easily make an accurate diagnosis of the valvular heart disease. This method should prove useful for the diagnosis of various heart diseases. en-copyright= kn-copyright= en-aut-name=NakagawaTomio en-aut-sei=Nakagawa en-aut-mei=Tomio kn-aut-name=中川富夫 kn-aut-sei=中川 kn-aut-mei=富夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 en-keyword=expert system kn-keyword=expert system en-keyword=MRI kn-keyword=MRI en-keyword=valvular heart disease kn-keyword=valvular heart disease END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1059 end-page=1068 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of myocardial damage and cardiac residual capacity by Tl-201 myocardial scintigraphy in valvular heart diseases kn-title=Tl-201心筋シンチグラフィーを用いた心臓弁膜症における心筋性状及び心予備能の評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study was performed to clarify whether the extent-score (Ex-Score) calculated by Tl-201 myocardial scintigraphy is a reliable indicator of the severity of myocardial damage and cardiac residual capacity in valvular heart diseases. The subjects consisted of 38 patients (10 with aortic regurgitation (AR), 4 with aortic stenosis (AS), 13 with mitral regurgitation (MR) and 11 with mitral stenosis (MS)). Ex-Score were significantly correlated with the severity of myocardial damage found in biopsied specimens obtained intraoperatively (correlation efficiency to Ex-Score with cell diameter in AR, % fibrosis in AR, cell diameter in AS, electron microscopic score in MR and % fibrosis in MS was 0.873, 0.734, 0.970, 0.913 and 0.659, respectively). Ex-Score were also correlated with cardiac residual capacity determined by radioisotope angiography (correlation efficiency to Ex-Score with % ⊿ ejection fraction in AR, % ⊿ end-systolic volume in MR, % ⊿ end-diastolic volume in MS was -0.764, 0.790 and -0.763, respectively). These results suggest that the severity of myocardial damage and cardiac residual capacity can be estimated by Tl-201 myocardial scintigraphy (Ex-Score) in valvular heart diseases. en-copyright= kn-copyright= en-aut-name=IndoShunju en-aut-sei=Indo en-aut-mei=Shunju kn-aut-name=因藤春秋 kn-aut-sei=因藤 kn-aut-mei=春秋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=Tl-201心筋シンチグラフィー kn-keyword=Tl-201心筋シンチグラフィー en-keyword=Extent Score kn-keyword=Extent Score en-keyword=心筋間線維量 kn-keyword=心筋間線維量 en-keyword=心筋細胞横径 kn-keyword=心筋細胞横径 en-keyword=電顕スコア kn-keyword=電顕スコア END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=9-10 article-no= start-page=923 end-page=929 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Combined resection of lung cancer and invaded aorta with the use of simple temporary bypass : A case reort kn-title=肺癌における簡易式一時バイパス法を用いた大動脈合併切除の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Left pneumonectomy and concomitant resection of the invaded aorta were performed by the simple temporary bypass method. The patient was a 59-year-old male with the chief complaint of left thoracic pain. The 57×43×35 mm tumor was in a region centering on segment 6 of the left lung and had infiltrated the descending aorta. It was diagnosed as T4NOMO, Stage IIIb. A bypass for blood flow was established between the aortic arch avobe the invasion and the left femoral artery, after ligation of the pulmonary artery and vein and closure of the left bronchial stump. Vascular blocking forceps were applied to the descending aorta above and below the tumor infiltration, and two thirds of the circumference of the invaded aortic wall, 4.0×3.0 cm, along with the tumor, was resected. Reconstruction was performed with an 18mm Cooly double velour graft. Blood pressure was monitored with a pressure probe inserted into the right femoral artery. It did not fall below 60 mmHg during the operation. Local recurrence was observed 10 montns post-operatively, and the patient is now receiving radiation therapy. en-copyright= kn-copyright= en-aut-name=InoueFumiyuki en-aut-sei=Inoue en-aut-mei=Fumiyuki kn-aut-name=井上文之 kn-aut-sei=井上 kn-aut-mei=文之 aut-affil-num=1 ORCID= en-aut-name=KamikawaYasuaki en-aut-sei=Kamikawa en-aut-mei=Yasuaki kn-aut-name=上川康明 kn-aut-sei=上川 kn-aut-mei=康明 aut-affil-num=2 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=3 ORCID= en-aut-name=GouchiAkira en-aut-sei=Gouchi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=4 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=5 ORCID= en-aut-name=HataTakato en-aut-sei=Hata en-aut-mei=Takato kn-aut-name=畑隆登 kn-aut-sei=畑 kn-aut-mei=隆登 aut-affil-num=6 ORCID= en-aut-name=KuinoseMasahiko en-aut-sei=Kuinose en-aut-mei=Masahiko kn-aut-name=杭ノ瀬昌彦 kn-aut-sei=杭ノ瀬 kn-aut-mei=昌彦 aut-affil-num=7 ORCID= en-aut-name=NanbaHirofumi en-aut-sei=Nanba en-aut-mei=Hirofumi kn-aut-name=難波宏文 kn-aut-sei=難波 kn-aut-mei=宏文 aut-affil-num=8 ORCID= en-aut-name=TaniguchiGyou en-aut-sei=Taniguchi en-aut-mei=Gyou kn-aut-name=谷口堯 kn-aut-sei=谷口 kn-aut-mei=堯 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=心臓病センター榊原病院外科 affil-num=7 en-affil= kn-affil=心臓病センター榊原病院外科 affil-num=8 en-affil= kn-affil=心臓病センター榊原病院外科 affil-num=9 en-affil= kn-affil=心臓病センター榊原病院外科 en-keyword=簡易式一時バイパス kn-keyword=簡易式一時バイパス en-keyword=大動脈合併切除 kn-keyword=大動脈合併切除 en-keyword=進行性肺癌 kn-keyword=進行性肺癌 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=97 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Attitude toward mental disorders : A comparative study of a attitude of nurses and attendants between Japan and Brazil kn-title=精神障害の対する態度―日本, ブラジルの看護婦, 看護士の態度の比較研究― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Attitude of nureses and attendants toward mental disorders was studied by using question-naire in Japan and Brazil. By factor analysis, three factors, negative attitude toward mental disorders and misunder-standing, positive attitude toward mental disorders and mental health ideology were extracted. The score of negative attitude toward mental disorders and misunderstanding was high in Brazil. This was suspected to be caused by poor knowledge about mental disorders. The score of positive attitude toward mental disorders was similar in Japan and Brazil. The score of mental health ideology was high in Japan. Mental health ideology is important to improve the attitude toward mental disorders both Japan and Brazil. It is important to spread knowledge about mental disorders in Brazil. In Japan, it is important to increase the interest in mental disorders. en-copyright= kn-copyright= en-aut-name=TakenamiKatsuko en-aut-sei=Takenami en-aut-mei=Katsuko kn-aut-name=武南克子 kn-aut-sei=武南 kn-aut-mei=克子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 en-keyword=精神障害に対する態度 kn-keyword=精神障害に対する態度 en-keyword=因子分析 kn-keyword=因子分析 en-keyword=精神保健的観念 kn-keyword=精神保健的観念 en-keyword=関心度 kn-keyword=関心度 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=9-10 article-no= start-page=885 end-page=895 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effect of nutritional intake on energy metabolism in postoperative patients after gastrointestinal surgery kn-title=間接熱量測定による消化器手術後のエネルギー代謝の検討―投与量･投与経路の比較― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Many studies have shown that enteral nutrition (EN) has nutritional effects comparable to total parenteral nutrition (TPN). However, the energy metabolism of the two different nutritioanl methods remains undefined. The two nutritional methods were compared by measuring the resting energy expenditure (REE) and nutritional assessment in postoperative patients after gastrointestinal surgery. The effects of different amounts of EN were also evaluated. Patients were diveded into three groups : Patients who were fed by EN of 30 Cal/kg/day (Group I, EN 30 : n=8), patients who were fed by EN of 40 Cal/kg/day (Group II, EN 40 : n=8), and patients who were fed by TPN of 30 Cal/kg/day (Group III, TPN : n=8). REE was measured by the Datex indirect calorimetry and nutritional assessment included the measurements of triceps skinfold thickness (TSF), arm muscle circumference (AMC), albumin and rapid turnover proteins. ％REE/BEE of EN30, EN40 and TPN was 122.5±14.3%, 138.2±16.8% and 107.6±10.5% respectively. The RQ for the three groups was about 1.0, which means the energy source of all regimens is carbohydrate. The TPN group showed a significantly higher RQ than the EN groups, but there was no difference in albumin or transferrin. There was no difference in nutritional effect between EN 30 and EN 40. No difference was found in anthropometric effects among the three groups. These findings suggest that 30 Cal/kg/day would be preferable to 40 Cal/kg/day in energy supply of enteral nutrition and that the energy expenditure of EN is higher than that of TPN under 30 Cal/kg/day nutrition. There is no difference among the three mehtods in terms of nutritional effects. en-copyright= kn-copyright= en-aut-name=YoshizaneKen en-aut-sei=Yoshizane en-aut-mei=Ken kn-aut-name=吉實憲 kn-aut-sei=吉實 kn-aut-mei=憲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=間接熱量計 kn-keyword=間接熱量計 en-keyword=経腸栄養 kn-keyword=経腸栄養 en-keyword=経静脈栄養 kn-keyword=経静脈栄養 en-keyword=代謝熱量 kn-keyword=代謝熱量 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=9-10 article-no= start-page=871 end-page=884 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study on cerebral venous circulatory disturbance kn-title=脳静脈環流障害に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A new experimental model of cerebral venous occlusion was developed and the cerebral hemodynamics and water content using this model were studied. An anatomical study of the cerebral venous system using methacyrl resin showed that the venous system was composed of superficial and deep veins. The superficial veins drained into the superior sagittal sinus (SSS). The SSS was connected to internal and external jugular veins via the transverse sinuses and diploic veins (DV), respectively. The cats were divided into three groups on the basis of the occlusion sites as follows ; Group I : SSS occlusion, Group II : DV occlusion, Group III : occlusion of both the SSS and DV. Intracranial pressure (ICP) and cerebral blood volume (CBV, photoelectric method) were monitored continuously. Local cerebral blood flow (1-CBF) and water content were measured by hydrogen clearance and gravimetric methods, respectively. Somatosensory evoked potential (SEP) was also recorded. Evans blue was injected intravenously to evaluate blood brain barrier permeability. There were no siginificant changes in ICP, 1-CBF or N1 latency of SEP after the occlusioon in Group I or II. However, in Group III, 1-CBF decreased significantly 2 hours after the occlusion as ICP increased gradually. N1 latency of SEP was prolonged and water content increased significantly. CBV increased immediately after the occlusion. There was no extravasated Evans blue. The increase in CBV and water content during sinus occlusion appeared to have led to intracranial hypertension and decrease of 1-CBF, which resulted in neural dysfunction. The brain edema in this model seemed to be hydrostatic edema or cytotoxic edema. en-copyright= kn-copyright= en-aut-name=SaijoToshikazu en-aut-sei=Saijo en-aut-mei=Toshikazu kn-aut-name=西条寿一 kn-aut-sei=西条 kn-aut-mei=寿一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科学教室 en-keyword=cerebral venous circulatory disturbance kn-keyword=cerebral venous circulatory disturbance en-keyword=dural sinus occlusion kn-keyword=dural sinus occlusion en-keyword=brain edema kn-keyword=brain edema en-keyword=cerebral blood flow kn-keyword=cerebral blood flow en-keyword=cerebral blood volume kn-keyword=cerebral blood volume END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=809 end-page=820 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on IgG subclass antibodies in asthmatics with late asthmatic responses Part 2. Antigen-specific IgG subclass antibodies in the BALF of asthmatics with late asthmatic responses kn-title=遅発型気道反応におけるIgG サブクラス抗体に関する研究　第2編　気管支肺胞洗浄液中抗原特異的 IgG サブクラス抗体と遅発型気道反応の関連について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Immunoglobulin classes which induce a non-immediate asthmatic response (non-IAR) in the case of low level of IgE antibody are still unknown, although IAR is mediated by IgE. To elucidate the relationship between antibodies and late asthmatic responses (LAR), antigen-specific IgG subclass antibodies in the serum and bronchoalveolar lavage fluid (BALF) of asthmatics were measured by avidin-biotin ELISA before provocation by antigen. The BALF levels of IgG and IgG1 antibodies to mite and Candida antigen in bronchial asthmatics were higher than those in healthy subjects (p<0.05). Followed by inhalation of house dust or Candida antigen, bronchial asthmatics were divided into group A (higher levels of BALF IgG1 antibody) and gourp B (lower levels of BALF IgG1 antibody). The percentages of LAR including DAR after inhalation of house dust antigen in group A were significantly higher than those in group B (p<0.05). The percentages of LAR including DAR after inhalation of Candida antigen in group A were significantly higher than those in group B (p<0.01). In asthmatics with LAR after inhalation of house dust antigen or Candida antigen, the BALF levels of antigen-specific IgG and IgG1 antibodies were significantly higher than those in asthmatics without LAR of healthy subjects (p<0.01). In asthmatics with LAR after inhalation of house dust antigen or Candida antigen, the BALF levels of antigen-specific IgG and IgG1 antibodies were significantly higher than those in asthmatics without LAR of healthy subjects (p<0.01). In asthmatics with LAR, the relative (to albumin) of coefficients of excretion (RCE) in the BALF of antigen-specific IgG and IgG1 antibodies were higher than those in asthmatics without LAR of healthy subjects. These findings suggest that local production of antigen-specific IgG and IgG1 antibodies incerases in asthmatics with LAR, and that these antibodies may induce LAR. en-copyright= kn-copyright= en-aut-name=OgurusuKazuro en-aut-sei=Ogurusu en-aut-mei=Kazuro kn-aut-name=小栗栖和郎 kn-aut-sei=小栗栖 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=遅発型気道反応 kn-keyword=遅発型気道反応 en-keyword=IgG サブクラス抗体 kn-keyword=IgG サブクラス抗体 en-keyword=気管支肺胞洗浄 kn-keyword=気管支肺胞洗浄 en-keyword=難治性喘息 kn-keyword=難治性喘息 en-keyword=抗原吸入誘発試験 kn-keyword=抗原吸入誘発試験 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=797 end-page=807 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on IgG subclass antibodies in asthmatics with late asthmatic responses Part 1. Serum antigen-specific IgG subclass antibodies in asthmatics with late asthmatic response kn-title=遅発型気道反応におけるIgG サブクラス抗体に関する研究　第1編　血清中抗原特異的 IgG サブクラス抗体と遅発型気道反応の関連について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The immediate asthmatic response is mainly induced by IgE-dependent mechanisms. However, the late asthmatic response (LAR) is induced by inhalation of antigens without the participation of antigen-specific IgE antibodies in some asthmatics, especially in intractable asthma induced by Candida antigen. To elucidate the relationship between antibodies and those bronchial responses, the antigen-specific IgG subclass antibodies in sera from asthmatics were measureed and compared with IgE antibody. The avidin-biotin ELISA (enzyme-linked immunosorbent assay) method was established for the measurement of specific IgG and IgG subclass antibodies to mite or Candida antigen. Serum levels of IgG and IgG1 antibodies to mite and Candida antigen in bronchial asthmatics were significantly higher than those in healthy subjects (p<0.01). Bronchial asthmatics who were tested with inhalation of house dust or Candida antigen were divided into group A (higher levels of serum IgG1 antibody) and group B (lower levels of serum IgG1 antibody). The percentage of LAR including DAR after inhalation of house dust antigen in group A were significantly higher than those in group B (p<0.01). The percentages of LAR and LAR including DAR after inhalation of Candida antigen in group A were significantly higherSerum levels of house du than those in group B(p<0.01). Serum levels of antigen-specific IgG and IgG1 antibodies in asthmatics with LAR after inhalation of house dust or Candida antigen were significantly higher than those in asthmatics with IAR or non-responders (p<0.01). The serum level of specific IgE antibody to these antigens in asthmatics with LAR after inhalation of house dust or Candida antigen was slightly lower than that in the asthmatics without LAR, though the difference was not significant. These findings suggest that high serum levels of specific IgG and IgG1 antibodies to adequate antigens play a role in inducing an attack in asthmatics with LAR. en-copyright= kn-copyright= en-aut-name=OgurusuKazuro en-aut-sei=Ogurusu en-aut-mei=Kazuro kn-aut-name=小栗栖和郎 kn-aut-sei=小栗栖 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=遅発型気道反応 kn-keyword=遅発型気道反応 en-keyword=IｇG サブクラス抗体 kn-keyword=IｇG サブクラス抗体 en-keyword=IgE 抗体 kn-keyword=IgE 抗体 en-keyword=抗原吸入誘発試験 kn-keyword=抗原吸入誘発試験 en-keyword=難治性喘息 kn-keyword=難治性喘息 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=539 end-page=547 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mechanism of immunotherapy related to the production of antigen specific IgG subclass antibodies and leukotrienes in bronchial asthmatics kn-title=気管支喘息患者における減感作療法に作用機序に関する研究―抗原特異的IgGサブクラス抗体とロイコトリエン産生能に及ぼす影響について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the mechanism of immunotherapy in bronchial asthma, the level of mite specific IgG subclass asntibodies (total IgG, IgG(1), IgG(4)) and the production of leukotrienes (LTB(4), LTC(4)) released from leukocytes were examined. Eighteen mite-sensitive asthmatic patiens who received immunotherapy with house dust extract for 1 year were dividel into two groups, the responsive patients and non-responsive patients. Before treatment and 1 year after treatment, the levels of mite specific serum IgG subclass antibodies were measured by enzyme-linked immunosorbent assay (ELISA) and the levels of LTs were measured by high performance liquid chromatography (HPLC). In the responsive group, the level of mite specific serum IgG(4) antibody was significantly increased (p<0.05), and the level of mite specific serum total IgG and IgG(1) antibody was decreased. The release of LTB(4) and LTC(4) from leukocytes stimulated by mite antigen was significantly decreased (p<0.05,p<0.05). These results indicate that increases in the antigen specific IgG(4) and the inhibiton of chemical madiators play important roles in the mechanism of immunotherapy. en-copyright= kn-copyright= en-aut-name=KatagiSachie en-aut-sei=Katagi en-aut-mei=Sachie kn-aut-name=片木幸恵 kn-aut-sei=片木 kn-aut-mei=幸恵 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=immunotherapy kn-keyword=immunotherapy en-keyword=IgG subclass antibodies kn-keyword=IgG subclass antibodies en-keyword=leukotrienes kn-keyword=leukotrienes END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=489 end-page=498 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical trial of enhancement method fro ultrasonographic diagnosis of thyroid nodules kn-title=結節性甲状腺腫の超音波診断における Enhancement 法の試み en-subtitle= kn-subtitle= en-abstract= kn-abstract=Enhancement in thyroid ultrasonography was investigated with thyroid lymphography by injection of Lipiodol into thyroid nodules in 50 patients. On plain thyroid ultrasonography (PU), the echo levels of normal and tumorous portions of the thyroid glands were evaluated. Then, the echo level ratios (P-N/T) were calculated. Moreover, by the same method, the echo level ratios between normal and tumorous portions of the thyroid glands were culculated 6 hours after Lipiodol injection (E-N/T), when the greatest enhancement was anticipated. The mean value of P-N/T was 1.305, and that of E-N/T was 1.474. The echo level ratio was significantly elevated in the enhancement method (p<0.0014). We concluded that the enhancement is obtained with Lipiodol injection into the normal portion of the thyroid glands, regardless of whether the tumor is benign or malignant and with or without cystic degeneration. This method is useful in promoting quality and location diagnosis of thyroid nodules. N : echo level value in the normal portion of thyroid gland T : echo level value in the tumorous portion of thyroid gland N/T : echo level raito en-copyright= kn-copyright= en-aut-name=TakeuchiRyuzo en-aut-sei=Takeuchi en-aut-mei=Ryuzo kn-aut-name=竹内龍三 kn-aut-sei=竹内 kn-aut-mei=龍三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=超音波診断 kn-keyword=超音波診断 en-keyword=結節性甲状腺腫 kn-keyword=結節性甲状腺腫 en-keyword=Enhancement kn-keyword=Enhancement en-keyword=甲状腺リンパ造影 kn-keyword=甲状腺リンパ造影 en-keyword=エコーレベル kn-keyword=エコーレベル END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=415 end-page=428 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of the dynamic states of pulmonary ventilation and perfusion in bronchial asthmatics using (133)Xe gas ventilation scintigraphy and (99m)Tc-MAA lung perfusion scintigraphy kn-title=気管支喘息における換気血流動態の研究―(133)Xe換気シンチ及び(99m)Tc-MAA血流シンチによる検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the organic changes and pathophysiology of the lungs in intractable asthmatics, the dynamic states of pulmonary ventilation and perfusion were analyzed in 15 bronchial asthmatic in the stable state using (133)Xe gas ventilation scintigraphy and (99m)Tc-MAA lung perfusion scintigraphy, respectively. Dysfunction of pulmonary ventilation and impairment of pulmonary perfusin were significantly severer in intractable asthmatics than in non-intractable asthmatics (p<0.01, P<0.05, respectively) and those of asthma caused by aging. Late onset asthmatics with a long duration of disease tended to show severe impairment of pulmonary perfusion. Above all the longer the duration of the disease the severer became the impairment of pulmonary perfusion in late onset intractable asthmatics (LOIA). These findings suggest that the progression of irreversible organic changes of lungs in LOIA is involved in the severity of brochial asthma. en-copyright= kn-copyright= en-aut-name=IshihamaHidenobu en-aut-sei=Ishihama en-aut-mei=Hidenobu kn-aut-name=石濱英暢 kn-aut-sei=石濱 kn-aut-mei=英暢 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=中高年発症型難治性喘息 (LOIA) kn-keyword=中高年発症型難治性喘息 (LOIA) en-keyword=換気シンチ kn-keyword=換気シンチ en-keyword=血流シンチ kn-keyword=血流シンチ END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=97 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of allergic gastroenteropathy Part 2. Existence of allergic gastroenteropathy caused by house dust kn-title=アレルギー性胃腸症の病態に関する研究 第2編 ハウスダストに起因するアレルギー性胃腸症の存在に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Not only many food substances but also other substances such as house dust(HD) may serve as causative allergens of allergic gastroenteropathy. To clarify the causative allergens and the pathogenesis of allergic gastroenteropathy, an oral loading test using HD, was applied to two patients with allergic gastroenteropathy caused by an unknown antigen, and with HD-sensitivity, and 24 bronchial asthmatics with or without HD-sensitivity, ther were examined using the ultrasonography of stomach reported previously. Two patients with gastroenteropathy showed a positive skin test and IgE RAST to HD, although they had bronchial asthma in the past history. Peripheral blood eosinophils in the 1st and 2nd patients showed a high (max 78%) and slightly increased (9%) value. The precipitating antibody in the two cases was negative, but lymphocyte blastogenesis to HD was enhanced in one case. During the oral loading test using HD, both patients had abdominal pain at immediate and late phase and acceleration of gastric peristalic movements was confirmed by ultrasonography. One of the 2 patients showed a strong gastrointestinal reaction during the delayed phase. LTC4 and histamine were considered to be involved in the abdominal pain of these cases. One of the 12 patients with bronchial asthma and HD-sensitivity showed an immediate reaction in oral loading test without abdominal pain, suggensting a correlation of the hypersensitivity between the bronchi and the digestive tract, including 2 former cases. en-copyright= kn-copyright= en-aut-name=ToyotaYuji en-aut-sei=Toyota en-aut-mei=Yuji kn-aut-name=豊田裕治 kn-aut-sei=豊田 kn-aut-mei=裕治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=アレルギー性胃腸症 kn-keyword=アレルギー性胃腸症 en-keyword=経口負荷試験 kn-keyword=経口負荷試験 en-keyword=超音波走査法 kn-keyword=超音波走査法 en-keyword=ハウスダスト kn-keyword=ハウスダスト en-keyword=気管支喘息 kn-keyword=気管支喘息 END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue=1 article-no= start-page=43 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Sulfur isotope ratios of some Roseki deposits in the Inner Zone of Southwest Japan kn-title=西南日本内帯のろう石鉱床の硫黄同位体比 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Sulfur isotope ratios of pyrite and alunite from 5 Roseki deposits in the Inner Zone of Southwest Japan were determined. The δ34S values of all pyrite samples were in the range from -13.2 to +2.3%, the variation range for each deposit being within 8%. In each deposit δ34S values of alunite were always higher than those of pyrite, which may be interpreted as that alunite was precipirated under more oxidizing conditions than pyrite. Sulfur isotope rations of the Roseki pyrite showed a distribution similar to that of ore sulfur from skarn and vein deposits in the same Zone. This suggests that the origin of sulfur of the Roseki deposits is also host igneous rocks. en-copyright= kn-copyright= en-aut-name=YamamotoMasahiro en-aut-sei=Yamamoto en-aut-mei=Masahiro kn-aut-name=山本雅弘 kn-aut-sei=山本 kn-aut-mei=雅弘 aut-affil-num=1 ORCID= en-aut-name=MatsudaToshihiko en-aut-sei=Matsuda en-aut-mei=Toshihiko kn-aut-name=松田敏彦 kn-aut-sei=松田 kn-aut-mei=敏彦 aut-affil-num=2 ORCID= en-aut-name=NakagawaRaiki en-aut-sei=Nakagawa en-aut-mei=Raiki kn-aut-name=中川頼記 kn-aut-sei=中川 kn-aut-mei=頼記 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学理学部地球科学科 affil-num=2 en-affil= kn-affil=岡山大学理学部地球科学科 affil-num=3 en-affil= kn-affil=株式会社ヨータイ en-keyword=sulfur isotope ratio kn-keyword=sulfur isotope ratio en-keyword=Roseki deposit kn-keyword=Roseki deposit en-keyword=pyrite kn-keyword=pyrite en-keyword=alunite kn-keyword=alunite END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=35 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Operative morbidity of elderly patients with gastrointestinal disease kn-title=高齢者消化器手術における術後合併症 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The operative morbidity and its relating factors were studied on 95 patients, 80 years old or older, operated for gastrointestinal (GI) diseases under general anesthesia at the department in a recent 11-year period. Among a total of 98 cases of GI diseases including 32 of gastric cancer, 17 of colorectal cancer, 16 of cholelithiasis and 33 of others, 108 procedures were performed for 38 gastric, 27 colorectal, 31 hepato-biliary-pancreatic and 12 other surgical conditions. Fifty-four operative complications occurred in 39 cases(41%), which were 13 respiratory, 11 delirium, 9 cardiovascular and 21 other complications. The respiratory morbidity rate was significantly high in males and significantly low in the cases receiving halanced epidural anesthesia. Postoperative delirium occurred more frequently in patients having an intraoperative blood loss of over 200 ml, and the cardiovascular morbidity rate was significantly high for an operative time of over 3 hours. The operative morbidity and 30-day operative mortality rate were significantly higher for emergency operations than for non-emergency operations. These findings suggest that, in the surgery for elderly patients and especially in an emergent situation, special care must be paid to decrease the quantity of bleeding and shorten the duration of operation by employing a proper procedure and anesthesia. en-copyright= kn-copyright= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=1 ORCID= en-aut-name=NakagawaKazuhiro en-aut-sei=Nakagawa en-aut-mei=Kazuhiro kn-aut-name=中川和彦 kn-aut-sei=中川 kn-aut-mei=和彦 aut-affil-num=2 ORCID= en-aut-name=SasakiHiroshi en-aut-sei=Sasaki en-aut-mei=Hiroshi kn-aut-name=佐々木寛 kn-aut-sei=佐々木 kn-aut-mei=寛 aut-affil-num=3 ORCID= en-aut-name=YamashitaYutaka en-aut-sei=Yamashita en-aut-mei=Yutaka kn-aut-name=山下裕 kn-aut-sei=山下 kn-aut-mei=裕 aut-affil-num=4 ORCID= en-aut-name=YumuraMasahito en-aut-sei=Yumura en-aut-mei=Masahito kn-aut-name=湯村正仁 kn-aut-sei=湯村 kn-aut-mei=正仁 aut-affil-num=5 ORCID= en-aut-name=KodaniJohji en-aut-sei=Kodani en-aut-mei=Johji kn-aut-name=小谷穣治 kn-aut-sei=小谷 kn-aut-mei=穣治 aut-affil-num=6 ORCID= en-aut-name=YunokiYasuhiro en-aut-sei=Yunoki en-aut-mei=Yasuhiro kn-aut-name=柚木靖弘 kn-aut-sei=柚木 kn-aut-mei=靖弘 aut-affil-num=7 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=鳥取市立病院外科 affil-num=2 en-affil= kn-affil=鳥取市立病院外科 affil-num=3 en-affil= kn-affil=鳥取市立病院外科 affil-num=4 en-affil= kn-affil=鳥取市立病院外科 affil-num=5 en-affil= kn-affil=鳥取市立病院外科 affil-num=6 en-affil= kn-affil=鳥取市立病院外科 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=高齢者 kn-keyword=高齢者 en-keyword=消化器手術 kn-keyword=消化器手術 en-keyword=術後合併症 kn-keyword=術後合併症 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=9-10 article-no= start-page=947 end-page=962 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Low dose melphalan for myelodysplastic syndrome kn-title=骨髄異形成症候群における melphalan 少量療法の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Myelodysplastic syndrome (MDS) is a disorder of multipotential hematopoietic stem cells. There is no effective therapy for MDS, especially for MDS associated with an excess of blasts, such as refractory anemia with excess blasts (RAEB) or RAEB in transformation (RAEBt). We previously reported the effect of K-18 (a human IgG-melphalan conjugate) in 15 patients with RAEB or RAEBt. The overall response rate was not high, but no side effects were noted. Although the mode of action of K-18 is not certain, it was suggested that the effect was associated with the activity of melpahlan itself. Therefore, low-dose melphalan therapy was initiated in eldery patients with RAEB or RAEBt. Six patients with RAEB and 12 patients with RAEBt received 2mg oral administration daily. Median age of the patients was 64. Six patients achieved complete remission (CR), one patient showed a partial response and four patients had a minor response. Total dosage of melpahlan for patients who achieved CR was 143±18 mg. Median duration of CR was 14.5 months. Serious toxicity was not encountered in any case and neither marrow suppression nor pancytopenia were observed in cases that achieved CR during the administration of melphalan. Changes in cell surface markers (CD34, CD33, CD13) were examined during the time course of CR in two cases. CD34 + cells decreased rapidly during the first two weeks and CD34-CD33+cells increased after four weeks of melpahlan administration. Studying the clinical course of CR with cell surface marker analysis provided evidence that melphalan therapy induced differentiation of transformed hemopoietic precursors. We conclude that daily chronic administration of melpahlan is a useful therapy for elderly patients with RAEB or RAEBt. en-copyright= kn-copyright= en-aut-name=TakabaSeiji en-aut-sei=Takaba en-aut-mei=Seiji kn-aut-name=高場成治 kn-aut-sei=高場 kn-aut-mei=成治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=RAEB kn-keyword=RAEB en-keyword=RAEBt kn-keyword=RAEBt en-keyword=low dose melpahlan therapy kn-keyword=low dose melpahlan therapy en-keyword=CD34 kn-keyword=CD34 en-keyword=CD33 kn-keyword=CD33 END start-ver=1.4 cd-journal=joma no-vol=109 cd-vols= no-issue=1-2 article-no= start-page=7 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Choroidal arteriole changes after experimental destruction of the outer layer of the retina kn-title=実験的網膜外層障害モデルの脈絡膜血管の変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of the present study is to clarify the changes of choroidal circulation developing in the selective injuries of the outer layer of the retina. One, 2, 3 weeks and 3 months after intravenous administration of Monoiodoacetic acid in the rabbits, choroidal vessels were observed using indocyanine green angiography (ICG). The diameter of retinal arterioles decreased significantly at 3 weeks and 3 months after the treatment and hypofluorescence in the background was observed at 3 months. Histological examination revealed significant decrease in choriocapillaris at 3 weeks, a thickening of the endothelial cytoplasma and a disappearance of fenestration in choriocapillaris after 3 months. These histological findings were considered to be a cause of hypofluorescence of background in ICG. The results suggest that the selective damage of the outer layer of the retina induce changes in the choroidal circulation. en-copyright= kn-copyright= en-aut-name=FujikawaEtsuko en-aut-sei=Fujikawa en-aut-mei=Etsuko kn-aut-name=藤川えつこ kn-aut-sei=藤川 kn-aut-mei=えつこ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部眼科学教室 en-keyword=網膜外層障害 kn-keyword=網膜外層障害 en-keyword=脈絡膜循環 kn-keyword=脈絡膜循環 en-keyword=モノヨード酢酸 kn-keyword=モノヨード酢酸 en-keyword=インドシアニングリーン蛍光眼底造影 kn-keyword=インドシアニングリーン蛍光眼底造影 END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=3-6 article-no= start-page=155 end-page=159 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laparoscopic cholecystectomy in 3 cases of hemodialysis patients kn-title=透析患者における腹腔鏡下胆囊摘出術の経験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Laparoscopic cholecystectomy has proven to be a safe and effective treatment for symptomatic gall stone disease. However, laparoscopic cholecystectomy in hemodialysis patients is considered to be relatively contraindicated because of anemia and bleeding tendency. We performed laparoscopic cholecystectomy in three patients being treated by hemodialysis for chronic renal failure. No significant complications were observed after surgery. Laparoscopic cholecystectomy should be considered for hemodialysis patients requiring cholecystectomy. en-copyright= kn-copyright= en-aut-name=TakaiKenichi en-aut-sei=Takai en-aut-mei=Kenichi kn-aut-name=高井研一 kn-aut-sei=高井 kn-aut-mei=研一 aut-affil-num=1 ORCID= en-aut-name=TaniaiKazuhi en-aut-sei=Taniai en-aut-mei=Kazuhi kn-aut-name=谷合一陽 kn-aut-sei=谷合 kn-aut-mei=一陽 aut-affil-num=2 ORCID= en-aut-name=TakatoriKatsuhiko en-aut-sei=Takatori en-aut-mei=Katsuhiko kn-aut-name=高取克彦 kn-aut-sei=高取 kn-aut-mei=克彦 aut-affil-num=3 ORCID= en-aut-name=OhtaSachiko en-aut-sei=Ohta en-aut-mei=Sachiko kn-aut-name=大田祥子 kn-aut-sei=大田 kn-aut-mei=祥子 aut-affil-num=4 ORCID= en-aut-name=KunitomiMie en-aut-sei=Kunitomi en-aut-mei=Mie kn-aut-name=国富三絵 kn-aut-sei=国富 kn-aut-mei=三絵 aut-affil-num=5 ORCID= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=6 ORCID= en-aut-name=KuroseMasao en-aut-sei=Kurose en-aut-mei=Masao kn-aut-name=黒瀬匤雄 kn-aut-sei=黒瀬 kn-aut-mei=匤雄 aut-affil-num=7 ORCID= en-aut-name=KojimaKazushi en-aut-sei=Kojima en-aut-mei=Kazushi kn-aut-name=小島一志 kn-aut-sei=小島 kn-aut-mei=一志 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山中央病院内科 affil-num=2 en-affil= kn-affil=岡山中央病院内科 affil-num=3 en-affil= kn-affil=岡山中央病院内科 affil-num=4 en-affil= kn-affil=岡山中央病院内科 affil-num=5 en-affil= kn-affil=岡山中央病院内科 affil-num=6 en-affil= kn-affil=岡山中央病院外科 affil-num=7 en-affil= kn-affil=岡山中央病院外科 affil-num=8 en-affil= kn-affil=岡山中央病院外科 en-keyword=腹腔鏡下胆囊摘出術 kn-keyword=腹腔鏡下胆囊摘出術 en-keyword=透析 kn-keyword=透析 END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=3-6 article-no= start-page=139 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Radioprotective effect of epinephrine as a vasoconstrictor in mouse oral mucosa and scalp kn-title=マウス口腔粘膜および頭部皮膚に対する血管収縮剤エピネフリンの放射線防護効果の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Epinephrine is the most widely used vasoconstrictive drug. However, its radioprotective potential has not yet been studied for radiation-induced mucositis and dermatitis. Other vasoconstrictive drugs induce a radioprotective effect, but are not used because of their severe side effects. We studied the radioprotective effect of epinephrine on the oral mucosa and scalp of the mice. The radiation dose was 20Gy in a single fraction to the head of the mouse. In the group treated with epinephrine ointment, secretion from the oral cavity was slight, body wieght loss was less and hair loss was observed in fewer cases compared to those in the group without of epinephrine ointment. The mechanism is thought to be related to oxygenation. Epinephrine causes vasoconstriction, therefore the blood supply is lowered and the oxygen concentration in the tissue decline. In conclusion, epinephrine is considered to have potential as a radioprotective ointment for mucous membranes and skin. en-copyright= kn-copyright= en-aut-name=GaoXianshu en-aut-sei=Gao en-aut-mei=Xianshu kn-aut-name=高献書 kn-aut-sei=高 kn-aut-mei=献書 aut-affil-num=1 ORCID= en-aut-name=NakagawaTomio en-aut-sei=Nakagawa en-aut-mei=Tomio kn-aut-name=中川富夫 kn-aut-sei=中川 kn-aut-mei=富夫 aut-affil-num=2 ORCID= en-aut-name=YamamotoMichinori en-aut-sei=Yamamoto en-aut-mei=Michinori kn-aut-name=山本道法 kn-aut-sei=山本 kn-aut-mei=道法 aut-affil-num=3 ORCID= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name=黒田昌宏 kn-aut-sei=黒田 kn-aut-mei=昌宏 aut-affil-num=4 ORCID= en-aut-name=SakaeKatsuyoshi en-aut-sei=Sakae en-aut-mei=Katsuyoshi kn-aut-name=栄勝美 kn-aut-sei=栄 kn-aut-mei=勝美 aut-affil-num=5 ORCID= en-aut-name=ShimizuMitsuharu en-aut-sei=Shimizu en-aut-mei=Mitsuharu kn-aut-name=清水光春 kn-aut-sei=清水 kn-aut-mei=光春 aut-affil-num=6 ORCID= en-aut-name=NiiyaHarutaka en-aut-sei=Niiya en-aut-mei=Harutaka kn-aut-name=新屋晴孝 kn-aut-sei=新屋 kn-aut-mei=晴孝 aut-affil-num=7 ORCID= en-aut-name=TakedaYoshihiro en-aut-sei=Takeda en-aut-mei=Yoshihiro kn-aut-name=竹田芳弘 kn-aut-sei=竹田 kn-aut-mei=芳弘 aut-affil-num=8 ORCID= en-aut-name=JojaIkuo en-aut-sei=Joja en-aut-mei=Ikuo kn-aut-name=上者郁夫 kn-aut-sei=上者 kn-aut-mei=郁夫 aut-affil-num=9 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name=平木祥夫 kn-aut-sei=平木 kn-aut-mei=祥夫 aut-affil-num=10 ORCID= en-aut-name=KawasakiShoji en-aut-sei=Kawasaki en-aut-mei=Shoji kn-aut-name=川崎祥二 kn-aut-sei=川崎 kn-aut-mei=祥二 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=11 en-affil= kn-affil=岡山大学医療技術短期大学部診療放射線技術学科 en-keyword=エピネフリン kn-keyword=エピネフリン en-keyword=放射線防護剤 kn-keyword=放射線防護剤 en-keyword=血管収縮 kn-keyword=血管収縮 en-keyword=酸素効果 kn-keyword=酸素効果 en-keyword=マウス粘膜皮膚 kn-keyword=マウス粘膜皮膚 END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=3-6 article-no= start-page=129 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Suppression of liver metastasis by biological response modifiers (BRMs) and the significance of local immunity in the liver kn-title=Biological response modifier (BRM) による肝転移抑制と肝局所免疫に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Efficacy of a combination therapy with two biological response modifiers (BRMs), oral PSK and systemic IL-2, was evaluated in a mouse model system of hepatic metastasis from colon cancer. Hepatic metastasis was significantly suppressed and the duration of survival was significantly prolonged by combination therapy, but not by either therapy alone. The therapeutic effects were attributable to the mechanism that non-MHC restricted cytotoxicity of hepatic non-parenchymal lymphocytes activated by IL-2 was augmented by PSK-activated Kupffer cells with direct cell-to-cell contact. These results suggest that local immunity in the liver plays an important role in the formation and development of hepatic metastasis and that the combination of these two BRMs may provide an effective new clinical therapy. en-copyright= kn-copyright= en-aut-name=TakahashiMasahiko en-aut-sei=Takahashi en-aut-mei=Masahiko kn-aut-name=高橋正彦 kn-aut-sei=高橋 kn-aut-mei=正彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科教室 en-keyword=肝移転 kn-keyword=肝移転 en-keyword=肝リンパ球 kn-keyword=肝リンパ球 en-keyword=クッパー細胞 kn-keyword=クッパー細胞 en-keyword=PSK kn-keyword=PSK en-keyword=interleukin 2 (IL-2) kn-keyword=interleukin 2 (IL-2) END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=3-6 article-no= start-page=83 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Comparison of postoperative circulatory, respiratory and immunological parameters between one-stage and two-stage surgery of intrathoracic esophageal carcinoma kn-title=循環，呼吸，免疫動態よりみた胸部食道癌に対する1期的手術と分割手術との比較検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=There are two major surgical procedures for excision of esophageal carcinoma and reconstruction of the esophagus: the one-stage procedure and the two-stage procedure. In the present study, we evaluated the two methods by comparing the cardiovascular, respiratory and immune parameters of 10 patients who underwent one-stage procedure with those of 10 other patients who underwent two-stage procedure. To estimate cardiovascular function, we measured the left ventricular stroke work index (LVSWI)-pulmonary capillary wedge pressure (PCWP). Most of the patients treated by the one-stage procedure showed a significant decrease in LVSWI-PCWP, whereas the index of patients treated by the two-stage procedure did not change much. When we assessed the respiratory system by forced vital capacity (FVC) and peak expiratory flow (PEF), the patients treated by the two-stage procedure recovered much faster and better than those receiving the one-stage procedure. Natural killer (NK) activity in lymphocytes was also measured as a marker of the immuno-reactive system. Although most patients show a drop in NK activity one week after major surgery, NK activity did not demonstrate a significant change in any of the patients who underwent the two-stage procedume. Thus, our systemic comparison of the three different parameters demonstrated better results after the two-stage procedure and we recommend it over the one-stage procedure, especially for aged and high risk patients. en-copyright= kn-copyright= en-aut-name=MuramatsuTomoyoshi en-aut-sei=Muramatsu en-aut-mei=Tomoyoshi kn-aut-name=村松友義 kn-aut-sei=村松 kn-aut-mei=友義 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=intrathoracic esophageal carcinoma kn-keyword=intrathoracic esophageal carcinoma en-keyword=one-stage procedure kn-keyword=one-stage procedure en-keyword=two-stage procedure kn-keyword=two-stage procedure en-keyword=reduction of operative stress kn-keyword=reduction of operative stress END start-ver=1.4 cd-journal=joma no-vol=111 cd-vols= no-issue=3-8 article-no= start-page=95 end-page=104 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Stress raises intraocular pressure in rabbits kn-title=ストレスが眼圧に与える影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose. To test whether encagement and volume load as stressors influence the intraocular pressure in rabbits. Method. Rabbits were encaged for an hour in a horizontally-plastic tube with an internal diameter of 13.2 cm and a length of 33.2cm. After the encagement, rabbits received a rapid intraveonus drip infusion of 5% glucose solution, 20 ml per kilogram of body weight, for 5-6 minutes. All experiments were performed at the same time of day. Results. The intraocular pressure after encagement (11.2±3.0mmHg as a mean and standard deviation) was significantly higher compared with that of control rabbits without encagement (9.2±1.0mmHg, Student t-test,p=0.046). This differnce became signifficantly larger when volume load was exerted on both groups of rabbits (p=0.0007). Serum levels of cortisol, adrenaline, and nordrenaline were significantly elevated afte encagement (n=6, p=0.0002, p=0.027, p=0.030, respectively). Venous pressure of the ear tended to increase in rabbits after encagement (15.8±3.1mmHg) compared with that of control rabbits (8.5±2.3mmHg,p=0.11), and the difference became significant when volume load was placed on each group of rabbits (p=0.021). Conclusions.Encagement, especially in combination with volume losd, increased the intraocular pressure in rabbits. The elevation of peripheral venous pressure caused by an increase in serum catecholamines would underlie the elevation of intraocular pressure proh-ably through the increased outflow resistance. en-copyright= kn-copyright= en-aut-name=MiyazakiYoshinori en-aut-sei=Miyazaki en-aut-mei=Yoshinori kn-aut-name=宮﨑義則 kn-aut-sei=宮﨑 kn-aut-mei=義則 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部眼科学講座 en-keyword=stress kn-keyword=stress en-keyword=intraocular pressure kn-keyword=intraocular pressure en-keyword=cortisol kn-keyword=cortisol en-keyword=catecholamines kn-keyword=catecholamines en-keyword=venus pressure kn-keyword=venus pressure END start-ver=1.4 cd-journal=joma no-vol=112 cd-vols= no-issue=3-8 article-no= start-page=39 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effects of health services facilities on medical expenditure for the elderly kn-title=老人保健施設が老人医療費に与える影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The first Health Services Facility was started in 1988, to provide the elderly with medical care services in Japan. The facilities have encouraged home care and their numbers have been increasing rapidly. In order to examine the effects of the facilities on medical expenditure for the elderly, cross-sectional and follow-up surveys were conducted with epidemiological analyses of the data from all 47 prefectures in 1990, 1993 and 1996. Multiple regression models were performed using several costs that used medical expenditure for the elderly as the explanatory variables. Furthermore, correlation coefficients between the changes in admission rates, duration of hospitalization, and the change of the numbers of beds in the facilities were calculated. The results are as follows. 1) There was a positive correlation between the cost of the facilities and medical expenditure for the elderly, but the effects have been decreasing with increased construction. 2) There was no relationship between the numbers of beds in the facilities and admission rate to the hospitals, but there was a correlation with the duration of hospitalization. en-copyright= kn-copyright= en-aut-name=OhtsuTadahiro en-aut-sei=Ohtsu en-aut-mei=Tadahiro kn-aut-name=大津忠弘 kn-aut-sei=大津 kn-aut-mei=忠弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部衛生学講座 en-keyword=老人保健施設 kn-keyword=老人保健施設 en-keyword=老人医療費 kn-keyword=老人医療費 en-keyword=入院受診率 kn-keyword=入院受診率 en-keyword=入院日数 kn-keyword=入院日数 END start-ver=1.4 cd-journal=joma no-vol=114 cd-vols= no-issue=3 article-no= start-page=289 end-page=296 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of phospholipase A(2) on proliferation of the primary cultured biliary epithelial cells from the extra-hepatic bile duct to rats using D-valine containing medium kn-title=D-バリン培地法により選択的に初代培養したラット胆管上皮細胞に対する Phospholipase A(2) の細胞増殖促進効果の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We hypothesized that a high level of phospholipase A(2) (PLA(2)) in bile juice works as a growth factor of biliary epithelial cells and causes hyperplastic change of the bile duct in pancreaticobiliary maljunction. in order to examine this hypothesis, we established a primary culture system of biliary epithelial cells from the extra-hepatic bile duct of rats. We successfully excluded fibroblasts from the epithelial cells using D-valine-containing medium and the single-cell cloning method. The established cells exhibited the characteristic features of rat bile duct epithelial cells. They were stained with anti-cytokeratin antibody, a marker protein of epithelial cells, were positive with PAS stain, and possessed the architectures of microvilli, tonofilament fibers and desmosomes. The effect of PLA(2) on proliferation of these cells was then examined. We clearly demonstrated that PLA(2) at nano-molar concentration (50nM, 100nM), that is, equivalent to the level of PLA(2) in the bile juice of pancreaticobiliary maljunction cases, caused a significant enhancement of epithelial cell proliferation. en-copyright= kn-copyright= en-aut-name=OguraKaoru en-aut-sei=Ogura en-aut-mei=Kaoru kn-aut-name=小倉薫 kn-aut-sei=小倉 kn-aut-mei=薫 aut-affil-num=1 ORCID= en-aut-name=WatanabeYasuhiro en-aut-sei=Watanabe en-aut-mei=Yasuhiro kn-aut-name=渡辺泰宏 kn-aut-sei=渡辺 kn-aut-mei=泰宏 aut-affil-num=2 ORCID= en-aut-name=HiramineChiharu en-aut-sei=Hiramine en-aut-mei=Chiharu kn-aut-name=平峯千春 kn-aut-sei=平峯 kn-aut-mei=千春 aut-affil-num=3 ORCID= en-aut-name=NakagawaToshitaka en-aut-sei=Nakagawa en-aut-mei=Toshitaka kn-aut-name=中川利孝 kn-aut-sei=中川 kn-aut-mei=利孝 aut-affil-num=4 ORCID= en-aut-name=TokiAkira en-aut-sei=Toki en-aut-mei=Akira kn-aut-name=土岐彰 kn-aut-sei=土岐 kn-aut-mei=彰 aut-affil-num=5 ORCID= en-aut-name=TokudaMasaaki en-aut-sei=Tokuda en-aut-mei=Masaaki kn-aut-name=徳田雅明 kn-aut-sei=徳田 kn-aut-mei=雅明 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=香川医科大学小児外科学 affil-num=2 en-affil= kn-affil=香川医科大学小児外科学 affil-num=3 en-affil= kn-affil=香川医科大学基礎看護学 affil-num=4 en-affil= kn-affil=香川医科大学附属実験実習機器センター affil-num=5 en-affil= kn-affil=香川医科大学小児外科学 affil-num=6 en-affil= kn-affil=香川医科大学生理学 en-keyword=膵・胆管合流異常 kn-keyword=膵・胆管合流異常 en-keyword=胆管上皮細胞 kn-keyword=胆管上皮細胞 en-keyword=D－バリン kn-keyword=D－バリン en-keyword=Phospholipase A(2) kn-keyword=Phospholipase A(2) en-keyword=細胞増殖 kn-keyword=細胞増殖 END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=2 article-no= start-page=119 end-page=123 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of adult Meckel's diveticul um with gastrointestinal bleeding kn-title=下血を主訴として発見された成人 Meckel 憩室に1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Gastrointestinal bleeding is often intermittent and its souree may be difficult to locate, resulting in delay of definitve diagnosis. Melena usually denotes bleeding not only from the upper, and lower gastrointestine but from the small int estine. Adult Meckel's diverticulum with gastrointestinal beeding is a relatively rare disease and often presents difficulty in preoperative diagnosis. A 65-year-old man was admitted to our hospital due to melena. Upper and lower gastrointestional endoscopy revealed no bleeding stie. (99m)Tc-pertechnetate scintigraphy is well known as a useful tool for preoperative delineation of Meckel's diverticulm. (99m)Tc-pertechnetate scintigraphy was performed in this patient and succesfully depicted the lesion noninvasively. In surgery, Meckel's diverticulum was found at an oral stie 90 cm from the terminalileum, and a sleevereseection was performed. Histopathologically, the diver ticulum had ectopic gastric muco sa and two 5mm ulcers on the border of the gastric mucosa. en-copyright= kn-copyright= en-aut-name=MorimotoYoshinori en-aut-sei=Morimoto en-aut-mei=Yoshinori kn-aut-name=守本芳典 kn-aut-sei=守本 kn-aut-mei=芳典 aut-affil-num=1 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博己 kn-aut-sei=岩垣 kn-aut-mei=博己 aut-affil-num=2 ORCID= en-aut-name=MorishitaNorio en-aut-sei=Morishita en-aut-mei=Norio kn-aut-name=森下紀夫 kn-aut-sei=森下 kn-aut-mei=紀夫 aut-affil-num=3 ORCID= en-aut-name=NakagawaHitoshi en-aut-sei=Nakagawa en-aut-mei=Hitoshi kn-aut-name=中川仁志 kn-aut-sei=中川 kn-aut-mei=仁志 aut-affil-num=4 ORCID= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=5 ORCID= en-aut-name=IsozakiHiroshi en-aut-sei=Isozaki en-aut-mei=Hiroshi kn-aut-name=磯崎博司 kn-aut-sei=磯崎 kn-aut-mei=博司 aut-affil-num=6 ORCID= en-aut-name=KajiEisuke en-aut-sei=Kaji en-aut-mei=Eisuke kn-aut-name=加地英輔 kn-aut-sei=加地 kn-aut-mei=英輔 aut-affil-num=7 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=8 ORCID= en-aut-name=MizunoMotoo en-aut-sei=Mizuno en-aut-mei=Motoo kn-aut-name=水野元夫 kn-aut-sei=水野 kn-aut-mei=元夫 aut-affil-num=9 ORCID= en-aut-name=ShiratoriYasushi en-aut-sei=Shiratori en-aut-mei=Yasushi kn-aut-name=白鳥康史 kn-aut-sei=白鳥 kn-aut-mei=康史 aut-affil-num=10 ORCID= en-aut-name=TnakaNoriaki en-aut-sei=Tnaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・肝臓・感染症内科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・肝臓・感染症内科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・肝臓・感染症内科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・肝臓・感染症内科学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 en-keyword=下血 kn-keyword=下血 en-keyword=成人 kn-keyword=成人 en-keyword=Meckel憩室 kn-keyword=Meckel憩室 en-keyword=異所性胃粘膜 kn-keyword=異所性胃粘膜 en-keyword=99mTc-pertechnetateシンチグラフィ kn-keyword=99mTc-pertechnetateシンチグラフィ END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=3 article-no= start-page=211 end-page=217 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨軟部腫瘍診断と治療における近年の進歩 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=尾﨑敏文 kn-aut-sei=尾﨑 kn-aut-mei=敏文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 整形外科学 en-keyword=骨軟部腫瘍 kn-keyword=骨軟部腫瘍 en-keyword=治療 kn-keyword=治療 en-keyword=生存率 kn-keyword=生存率 en-keyword=機能再建 kn-keyword=機能再建 END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=2 article-no= start-page=97 end-page=103 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=大腸癌におけるKRAS，BRAF 遺伝子突然変異とDNA メチル化 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=永坂岳司 kn-aut-sei=永坂 kn-aut-mei=岳司 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=笹本博美 kn-aut-sei=笹本 kn-aut-mei=博美 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高畑隆臣 kn-aut-sei=高畑 kn-aut-mei=隆臣 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=竹田正範 kn-aut-sei=竹田 kn-aut-mei=正範 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=木村圭吾 kn-aut-sei=木村 kn-aut-mei=圭吾 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=内田卓之 kn-aut-sei=内田 kn-aut-mei=卓之 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石井龍宏 kn-aut-sei=石井 kn-aut-mei=龍宏 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=長尾厚樹 kn-aut-sei=長尾 kn-aut-mei=厚樹 aut-affil-num=9 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小南賢吉郎 kn-aut-sei=小南 kn-aut-mei=賢吉郎 aut-affil-num=10 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川仁志 kn-aut-sei=中川 kn-aut-mei=仁志 aut-affil-num=11 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=神原健 kn-aut-sei=神原 kn-aut-mei=健 aut-affil-num=12 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=能登原憲司 kn-aut-sei=能登原 kn-aut-mei=憲司 aut-affil-num=13 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=磯崎博司 kn-aut-sei=磯崎 kn-aut-mei=博司 aut-affil-num=14 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=13 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=14 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=15 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 en-keyword=Colorectal Cancer kn-keyword=Colorectal Cancer en-keyword=MSI kn-keyword=MSI en-keyword=DNA Methylation kn-keyword=DNA Methylation en-keyword=KRAS mutation kn-keyword=KRAS mutation en-keyword=BRAF mutation kn-keyword=BRAF mutation END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=1 article-no= start-page=41 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two cases of acute pulmonary embolism after esophageal cancer operation kn-title=早期診断し得た食道癌術後静脈血栓塞栓症の2例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We encountered two cases of pulmonary embolism (PE)/venous thrombs (DVT) after surgery for esophageal cancer. The first case was a 58-year-old male. He underwent a subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. His postoperative course was stable; however, 13 days after the operation､ he had an elevated fever and pulmonary thrombi were observed on CT-scan screening. Scintigraphy confirmed the thrombi. An inferior vena cava filter (IVCF) was inserted and anti-coagulation therapy using heparin was started. His fever subsided, and 35 days after the operation, the thrombi disappeared. He was discharged thereafter and is being followed up using warfarin. The second case was a 74-year-old male. He also underwent subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. A central line was inserted via right femoral vein; however, the artery was injured and pressurization to the vessel was needed. His post-operative course was stable and symptom-free; however, ultrasound screening detected DVT in his right femoral vein. IVCF was mserted and anti-coagulation therapy was begun, thrombi disappeared 8 days after the therapy. en-copyright= kn-copyright= en-aut-name=KanazawaTakashi en-aut-sei=Kanazawa en-aut-mei=Takashi kn-aut-name=金澤卓 kn-aut-sei=金澤 kn-aut-mei=卓 aut-affil-num=1 ORCID= en-aut-name=WatababeNobuyuki en-aut-sei=Watababe en-aut-mei=Nobuyuki kn-aut-name=渡辺信之 kn-aut-sei=渡辺 kn-aut-mei=信之 aut-affil-num=2 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=3 ORCID= en-aut-name=KobayashiMasahiko en-aut-sei=Kobayashi en-aut-mei=Masahiko kn-aut-name=小林正彦 kn-aut-sei=小林 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=5 ORCID= en-aut-name=YamatsujiTomoki en-aut-sei=Yamatsuji en-aut-mei=Tomoki kn-aut-name=山辻知樹 kn-aut-sei=山辻 kn-aut-mei=知樹 aut-affil-num=6 ORCID= en-aut-name=KobayashiNaoya en-aut-sei=Kobayashi en-aut-mei=Naoya kn-aut-name=小林直哉 kn-aut-sei=小林 kn-aut-mei=直哉 aut-affil-num=7 ORCID= en-aut-name=FujiwaraTohsiyoshi en-aut-sei=Fujiwara en-aut-mei=Tohsiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=8 ORCID= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=9 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=10 ORCID= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=11 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 en-keyword=食道癌 (esophageal cancer) kn-keyword=食道癌 (esophageal cancer) en-keyword=肺塞栓症 (pulmonary embolism) kn-keyword=肺塞栓症 (pulmonary embolism) en-keyword=深部静脈血栓症 (deep venous thrombs) kn-keyword=深部静脈血栓症 (deep venous thrombs) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=267 end-page=272 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A collaborative approach to head and neck carcinoma for oral surgeons, head and neck surgeons, and plastic surgeons: The role of oral surgeons in two cases kn-title=頭頸部癌における耳鼻咽喉科, 形成外科, 口腔外科3科合同手術の意義 : 2症例における口腔外科の役割を中心に en-subtitle= kn-subtitle= en-abstract= kn-abstract=There is a medical team approach used in many hospitals for oral cancer patients. The members are head & neck surgeons and plastic surgeons, or oral surgeons and plastic surgeons. However, in Japan, it is very difficult for oral surgeons to cooperate with head & neck surgeons, except in the case of extractions and oral health care, because both surgeons treat oral carcinomas and there is therefore a conflict in their scope of practice. We believe it desirable for head & neck surgeons to treat oral cancer patients with tumors extending to other regions, and oral surgeons should be in charge of occlusion in head and neck carcinomas. We treated two patients with oral carcinomas in collaboration with head and neck surgeons and plastic surgeons, with head & neck surgeons resecting the tumors, plastic surgeons reconstructing, and oral surgeons (dentists) taking charge of the occlusion for patients in the operating room. This collaboration resulted in patients having good position of the temporomandibular joint and occlusions after the operation. We therefore conclude that this collaborative team approach may be of benefit to the patients. en-copyright= kn-copyright= en-aut-name=MizukawaNobuyoshi en-aut-sei=Mizukawa en-aut-mei=Nobuyoshi kn-aut-name=水川展吉 kn-aut-sei=水川 kn-aut-mei=展吉 aut-affil-num=1 ORCID= en-aut-name=TominagaSusumu en-aut-sei=Tominaga en-aut-mei=Susumu kn-aut-name=冨永進 kn-aut-sei=冨永 kn-aut-mei=進 aut-affil-num=2 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name=木股敬裕 kn-aut-sei=木股 kn-aut-mei=敬裕 aut-affil-num=3 ORCID= en-aut-name=OnodaTomoo en-aut-sei=Onoda en-aut-mei=Tomoo kn-aut-name=小野田友男 kn-aut-sei=小野田 kn-aut-mei=友男 aut-affil-num=4 ORCID= en-aut-name=NomiyaShigenobu en-aut-sei=Nomiya en-aut-mei=Shigenobu kn-aut-name=野宮重信 kn-aut-sei=野宮 kn-aut-mei=重信 aut-affil-num=5 ORCID= en-aut-name=SugiyamaNarushi en-aut-sei=Sugiyama en-aut-mei=Narushi kn-aut-name=杉山成史 kn-aut-sei=杉山 kn-aut-mei=成史 aut-affil-num=6 ORCID= en-aut-name=KawamotoTomoaki en-aut-sei=Kawamoto en-aut-mei=Tomoaki kn-aut-name=川本知明 kn-aut-sei=川本 kn-aut-mei=知明 aut-affil-num=7 ORCID= en-aut-name=YamachikaEiki en-aut-sei=Yamachika en-aut-mei=Eiki kn-aut-name=山近英樹 kn-aut-sei=山近 kn-aut-mei=英樹 aut-affil-num=8 ORCID= en-aut-name=UenoTakaaki en-aut-sei=Ueno en-aut-mei=Takaaki kn-aut-name=植野高章 kn-aut-sei=植野 kn-aut-mei=高章 aut-affil-num=9 ORCID= en-aut-name=TakagiShin en-aut-sei=Takagi en-aut-mei=Shin kn-aut-name=高木慎 kn-aut-sei=高木 kn-aut-mei=慎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 口腔外科再建系 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 形成再建外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 形成再建外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 歯顎口腔機能再建外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 歯顎口腔機能再建外科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 歯顎口腔機能再建外科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 歯顎口腔機能再建外科学 en-keyword=チーム医療 (medical team approach) kn-keyword=チーム医療 (medical team approach) en-keyword=頭頸部癌 (head and neck carcinoma) kn-keyword=頭頸部癌 (head and neck carcinoma) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=127 end-page=129 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=XAGE-1expression in non-small cell Lung cancer and antibody response in patients kn-title=非小細胞肺癌における癌・精巣抗原XAGE-1の発現と免疫応答の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaKazuhiko en-aut-sei=Nakagawa en-aut-mei=Kazuhiko kn-aut-name=中川和彦 kn-aut-sei=中川 kn-aut-mei=和彦 aut-affil-num=1 ORCID= en-aut-name=NoguchiYuji en-aut-sei=Noguchi en-aut-mei=Yuji kn-aut-name=野口雄司 kn-aut-sei=野口 kn-aut-mei=雄司 aut-affil-num=2 ORCID= en-aut-name=OkumuraHideo en-aut-sei=Okumura en-aut-mei=Hideo kn-aut-name=奥村英雄 kn-aut-sei=奥村 kn-aut-mei=英雄 aut-affil-num=3 ORCID= en-aut-name=SatoShuichiro en-aut-sei=Sato en-aut-mei=Shuichiro kn-aut-name=佐藤修一郎 kn-aut-sei=佐藤 kn-aut-mei=修一郎 aut-affil-num=4 ORCID= en-aut-name=TanakaMotoyuki en-aut-sei=Tanaka en-aut-mei=Motoyuki kn-aut-name=田中志幸 kn-aut-sei=田中 kn-aut-mei=志幸 aut-affil-num=5 ORCID= en-aut-name=ShimonoMichihide en-aut-sei=Shimono en-aut-mei=Michihide kn-aut-name=下野玄英 kn-aut-sei=下野 kn-aut-mei=玄英 aut-affil-num=6 ORCID= en-aut-name=Ali EldibAli Mohamed en-aut-sei=Ali Eldib en-aut-mei=Ali Mohamed kn-aut-name=アリ・エルディブ アリモハメド kn-aut-sei=アリ・エルディブ アリ kn-aut-mei=モハメド aut-affil-num=7 ORCID= en-aut-name=AoeMotoi en-aut-sei=Aoe en-aut-mei=Motoi kn-aut-name=青江基 kn-aut-sei=青江 kn-aut-mei=基 aut-affil-num=8 ORCID= en-aut-name=OnoToshiro en-aut-sei=Ono en-aut-mei=Toshiro kn-aut-name=小野俊朗 kn-aut-sei=小野 kn-aut-mei=俊朗 aut-affil-num=9 ORCID= en-aut-name=UenakaAkiko en-aut-sei=Uenaka en-aut-mei=Akiko kn-aut-name=上中明子 kn-aut-sei=上中 kn-aut-mei=明子 aut-affil-num=10 ORCID= en-aut-name=OharaNobuya en-aut-sei=Ohara en-aut-mei=Nobuya kn-aut-name=大原信哉 kn-aut-sei=大原 kn-aut-mei=信哉 aut-affil-num=11 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name=吉野正 kn-aut-sei=吉野 kn-aut-mei=正 aut-affil-num=12 ORCID= en-aut-name=YamashitaKazuki en-aut-sei=Yamashita en-aut-mei=Kazuki kn-aut-name=山下和城 kn-aut-sei=山下 kn-aut-mei=和城 aut-affil-num=13 ORCID= en-aut-name=TsunodaTsukasa en-aut-sei=Tsunoda en-aut-mei=Tsukasa kn-aut-name=角田司 kn-aut-sei=角田 kn-aut-mei=司 aut-affil-num=14 ORCID= en-aut-name=ShimizuNobuyoshi en-aut-sei=Shimizu en-aut-mei=Nobuyoshi kn-aut-name=清水信義 kn-aut-sei=清水 kn-aut-mei=信義 aut-affil-num=15 ORCID= en-aut-name=NakayamaEiichi en-aut-sei=Nakayama en-aut-mei=Eiichi kn-aut-name=中山睿一 kn-aut-sei=中山 kn-aut-mei=睿一 aut-affil-num=16 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学 affil-num=9 en-affil= kn-affil=岡山大学自然生命科学研究支援センター affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理・病態学 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理・病態学 affil-num=13 en-affil= kn-affil=川崎医科大学附属病院 消化器外科学 affil-num=14 en-affil= kn-affil=川崎医科大学附属病院 消化器外科学 affil-num=15 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学 affil-num=16 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 en-keyword=XAGE-1b kn-keyword=XAGE-1b en-keyword=癌精巣抗原 kn-keyword=癌精巣抗原 en-keyword=非小細胞肺癌 kn-keyword=非小細胞肺癌 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=CT index を用いた（漏斗胸に対する）Nuss法の評価 kn-title=Evaluation of the Nuss procedure using pre and postoperative CT index en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaYoshikiyo en-aut-sei=Nakagawa en-aut-mei=Yoshikiyo kn-aut-name=中川賀清 kn-aut-sei=中川 kn-aut-mei=賀清 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=HGF・PGIS遺伝子の局所的共導入による皮弁生着率の向上 kn-title=Improvement of survival of skin flaps by combined gene transfer of hepatocyte growth factor and prostacyclin synthase en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaAya en-aut-sei=Nakagawa en-aut-mei=Aya kn-aut-name=中川彩 kn-aut-sei=中川 kn-aut-mei=彩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=1 article-no= start-page=7 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200803 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Statistical modeling for analysis of malaria epidemic behavior at Ishigaki　Island kn-title=石垣島におけるマラリア流行解析のための統計モデリング en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is necessary to consider a stochastic variability in modeling malaria epidemic behavior since the　malaria infection cycle essentially depends on stochastic elements. For this requirement, we need to construct an appropriate statistical model from available data in advance. In this report, we provide some statistical models for the analysis of malaria epidemic behavior at Ishigaki Island. These models can be used for recurrence of past malaria epidemic and prediction of future malaria epidemic at Ishigaki Island. en-copyright= kn-copyright= en-aut-name=UekiMasao en-aut-sei=Ueki en-aut-mei=Masao kn-aut-name=植木優夫 kn-aut-sei=植木 kn-aut-mei=優夫 aut-affil-num=1 ORCID= en-aut-name=NakagawaYuuki en-aut-sei=Nakagawa en-aut-mei=Yuuki kn-aut-name=中川祐希 kn-aut-sei=中川 kn-aut-mei=祐希 aut-affil-num=2 ORCID= en-aut-name=FuedaKaoru en-aut-sei=Fueda en-aut-mei=Kaoru kn-aut-name=笛田薫 kn-aut-sei=笛田 kn-aut-mei=薫 aut-affil-num=3 ORCID= en-aut-name=IshikawaHirofumi en-aut-sei=Ishikawa en-aut-mei=Hirofumi kn-aut-name=石川洋文 kn-aut-sei=石川 kn-aut-mei=洋文 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 en-keyword=Anopheles minimus, kn-keyword=Anopheles minimus, en-keyword=generalized liner model kn-keyword=generalized liner model en-keyword=Ishigaki Island kn-keyword=Ishigaki Island en-keyword=malaria epidemic behavior kn-keyword=malaria epidemic behavior en-keyword=prediction kn-keyword=prediction en-keyword=stochastic model kn-keyword=stochastic model END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue=2 article-no= start-page=57 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200709 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Inflation and Announcement−Drift −Discussion about the Inflation Illusion Hypothesis− kn-title=インフレーションとアナウンスメントドリフト －インフレーション錯覚仮説に関する検討－ en-subtitle= kn-subtitle= en-abstract= kn-abstract=本稿の目的は，利益のポストアナウンスメントドリフト（post−earnings−announcement−drift）を説明する一つの仮説であるインフレーション錯覚仮説（inflation illusion hypothesis）について概観しながら，この仮説のポストアナウンスメントドリフト（post−announcement−drift）研究における意義について考察することである。ポストアナウンスメントドリフトの検証は，財務情報と決算発表後の株価との関連性を判断する上で有効であるが，その関連性がインフレーションと関係しているということは，インフレーションが生じている場合の財務情報の有用性について考察する上で役立つかもしれない。ポストアナウンスメントドリフトは，財務情報が発表された後，数ヶ月間にわたり，プラスのサプライズに対して株価が市場平均よりも上昇し，マイナスのサプライズに対して下落するアノマリー現象である。また，ポストアナウンスメントドリフトに関するこれまでの研究では，利益のポストアナウンスメントドリフトだけではなく，キャッシュフローのポストアナウンスメントドリフト （post−cash−flow−announcement−drift）についても検証が行われており，それらの存在が確認されているが，このことは利益情報やキャッシュフロー情報の決算発表後における株価との関連性を証拠付けている。しかしながら，利益情報もキャッシュフロー情報も一般に公表されており，誰でもコストをかけることなく利用可能であるにもかかわらず，ポストアナウンスメントドリフトが生じるのはなぜかという疑問点は依然として存在している。ポストアナウンスメントドリフトの存在が何度も確認される一方で，その現象が発生する原因については，いまだ完全には突き止められていないのである。このような状況において，インフレーション錯覚仮説は，利益のポストアナウンスメントドリフトが生じる原因をインフレーションで説明することを試みるものである。その仮説の主旨は，インフレーション下では，投資家は企業の将来業績にイリュージョン（錯覚）をいだいており，そのことが投資家の合理性を低下させて，ポストアナウンスメントドリフトを生じさせるということである。本稿の構成は以下のとおりである。まず，次節では，アナウンスメントドリフト研究におけるインフレーション錯覚仮説の位置づけについて説明する。第３節では，インフレーション錯覚仮説を検証したChordia and Shivakumar（２００５）を概観して，その分析手法と主な分析結果を確認し，第４節では，日本で検証を行う際に認識しておくべき点を指摘して，最後にむすびとしたい。 en-copyright= kn-copyright= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=38 cd-vols= no-issue=1 article-no= start-page=21 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=200606 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Post−Announcement Drift and Cash Flows kn-title=ポストアナウンスメントドリフトとキャッシュフロー en-subtitle= kn-subtitle= en-abstract=The purpose of this paper is to discuss the relationship between post−announcement drift and the usefulness of cash flow information. The post−announcement drift is the phenomenon that stock prices continue changing for a direction even after the announcement days. The first evidence of the post−announcement drift was indicated by the Ball and Brown (1968), and then many papers have been illustrated the robustness of the evidences for the post−announcement drift phenomenon and tried to explain why the phenomenon occur. On the other hand, the listed companies disclose the statement of cash flows, but the many papers focused on only the post “earnings” announcement drift. So, this paper addresses not only earnings but also “cash flows” and “accruals”. As for the causes of the post−earnings−announcement drift, we could classify roughly into two explanations. First, the error of abnormal returns estimations causes the post−earnings−announcement drift. In other words, the explanation asserts that the capital asset pricing model (CAPM) is not adequate to calculate the capital cost enough to reflect the risk of stocks. That is to say, the explanation addresses the methodological issues. Bernard and Thomas (1989) said it “explanation based on incomplete risk adjustment”. The other is said “explanation based on delayed response to information” by them. In the case, we could interpret the phenomenon as the insufficiency of the investors’ understanding for the accounting information and other the limitations in the real　transactions. Many papers, for example Rayburn (1986), Wilson (1986) (1987), Ali (1994), Pfeiffer et al. (1998), Barth et al. (1999) (2001), documented the usefulness of cash flows information, and many papers investigated the post− earnings−announcement drift, but did not for cash flows one. So, this paper addressed the post−cash−flows− announcement drift and post−accruals−announcement drift, especially the relationship between them and　usefulness of cash flows information. This paper has two conclusions, which are (1) the usefulness of cash flows information might influence the interpretation of post−earnings−announcement drift, (2) it is necessary that we will investigate the post−cash− flows−announcement drift. kn-abstract=ポストアナウンスメントドリフト（post−announcement drift）と呼ばれる現象がある。その大意は，決算発表後における株価の変化ないしは動向というほどの意味合いであるが，より厳密に言えば，決算発表後における決算発表で開示されたある財務情報と整合的な株価変化を意味する。例えば，利益額ないしは営業活動によるキャッシュフローの金額が前期よりも増加した（期待を上回った）という情報が公表された後しばらくの間生じる市場リターンを超える株価上昇や，前期よりも減少した（期待を下回った）場合に生じる株価下落といった現象のことである。なお，財務情報が発表される前の そのような株価動向は，プレアナウンスメントドリフト（pre−announcement drift）と呼ばれ，それらの二つをあわせてアナウンスメントドリフト（announcement drift）と呼ばれている。ポストアナウンスメントドリフト現象は，Ball and Brown（１９６８）がこの現象を裏付ける証拠を示して以来，実証的な会計学の領域で関心を集めてきた。 本稿では財務情報の有用性の視点から，この現象とキャッシュフロー情報の有用性との関係を探ってみたい。敷衍すれば，本稿の目的は，利益のポストアナウンスメントドリフト（post−earnings−announcement drift）に関するこれまでの研究を眺めた上で，キャッシュフローのポストアナウンスメントドリフト（post−cash−flows−announcement drift）を扱っているShivakumar（２００６）の検証内容について考察しながら，ポストアナウンスメントドリフト現象とキャッシュフロー情報の有用性との関係について検討することである。ポストアナウンスメントドリフトについては，米国を中心にこれまでに多くの研究が展開されてきた。しかしながら，それらの先行研究は利益のポストアナウンスメントドリフトに関するものがほとんどである。これに対して，本稿ではキャッシュフローのポストアナウンスメントドリフトについても目を向けている。また，キャッシュフロー情報の有用性に関する研究は，これまで期待外キャッシュフロー変数とリターンとの関連性（情報内容）やキャッシュフローモデルの株価説明力（持分価値評価）という視点から行われることが多かったが，本稿では，キャッシュフロー情報の有用性とポストアナウンスメントドリフトとの関係について検討している。これらが本稿の意義である。本稿の構成は以下のとおりである。まず次節では，利益のポストアナウンスメントドリフトに関するこれまでの研究について，その現象の説明方法を交えながら説明する。次に，第３節では，キャッシュフローのポストアナウンスメントドリフトを検証する意義について，その前提となる考え方やキャッシュフロー情報の有用性との結びつきと関係づけて考察する。最後に，本稿の検討事項を整理し，今後の検討課題について考察することで結びとしたい。 en-copyright= kn-copyright= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=中川豊隆 kn-aut-sei=中川 kn-aut-mei=豊隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=1 cd-vols= no-issue= article-no= start-page=91 end-page=97 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Neurophysiological Implications of an Atypical Slow Negative Potential in Short Interval CNV　Paradigm kn-title=CNVの記録条件と非定型波形の生理学的意義 en-subtitle= kn-subtitle= en-abstract=CNVの記録条件を検討する目的で、健康若年成人49名（男12、女37）を対象にS(1)-S(2)+Rパラダイムを用いてCNVを記録した。S(1)-S(2)間隔2秒のほうが3秒よりも安定してCNVが記録されたが、刺激間隔とは無関係に26～30％の試行で二峰性の陰性変動をもつ非定型な緩電位が記録された。この緩電位は同一被検者でも出現性が一貫せず、個体差よりも被検者の状態に依存していた。二峰性陰性波のうち、後期成分は準備電位に対応するものと思われたが、前期成分はS(1)後900～1100msecにピークをもつ陰性波で、これまで報告されたCNVの要素波とは対応しなかった。また、この非定型CNVを示す被検者ではCNV出現が不安定で、SVRおよびパターンVEPの振幅が低い傾向があり、試行時の被検者の覚醒水準低下よるものではないかと考えられた。 kn-abstract=We recorded a slow negative potential from Cz (10/20 method) in 49 healthy students (12 male, 37 female, mean age 19.1) by a short interstumulus interval CNV paradigm. The interstimulus interval was 2 or 3 seconds, the warning stimulus presented at random or regular interval at 0.2 Hz. An atypical negative variation with two separated negative peaks was recorded in 26.0-30.6% trials regardless of interstimulus interval or modality of warning stimulus presentation, while a typical CNV was recorded in 32.0-59.2% of trials. No apparent negative variation was recorded in 14.3-18.4% in 2 seconds interstimulus interval, and 28-38% in 3 seconds interstimulus interval, showing that 2 seconds interval is better to get stable CNV recording than 3 seconds interval. The first negative wave of the atypical negative variation was 692-799msec in duration, but frequently prolonged to 1000msec or more in 3 seconds interval. It usually had negative peak around 900-1100msec, but sometimes around 1500msec. This features are different from any reported negative components of CNV. The second negative wave began 800-1200msec before second stimulus, and had its peak just before second stimulus, showing common features with readiness potential. The appearance of CNV was unsatble in the students in which the atypical negative variation was recorded in regular, 2 seconds intersitimulus interval, and the amplitude of slow vertex response and pattern reversal visual evoked potential was lower in thses students than in the students in which a typical CNV was recorded more than 3 times in total 4 times of trials. These findings indicate that the atypical variation observed in this study is due to a lowered arousal level or cortical neuronal activity, rather than a separated appearance of different components of CNV. en-copyright= kn-copyright= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=岡本基 kn-aut-sei=岡本 kn-aut-mei=基 aut-affil-num=1 ORCID= en-aut-name=TeminoMasato en-aut-sei=Temino en-aut-mei=Masato kn-aut-name=手蓑正人 kn-aut-sei=手蓑 kn-aut-mei=正人 aut-affil-num=2 ORCID= en-aut-name=NakagawaNaohisa en-aut-sei=Nakagawa en-aut-mei=Naohisa kn-aut-name=中川尚久 kn-aut-sei=中川 kn-aut-mei=尚久 aut-affil-num=3 ORCID= en-aut-name=MoriHirokazu en-aut-sei=Mori en-aut-mei=Hirokazu kn-aut-name=森宏和 kn-aut-sei=森 kn-aut-mei=宏和 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 en-keyword=contingent negative variation kn-keyword=contingent negative variation en-keyword=atypical slow negative potential kn-keyword=atypical slow negative potential en-keyword=arousal level kn-keyword=arousal level en-keyword=slow vertex response kn-keyword=slow vertex response en-keyword=visual evoked potential kn-keyword=visual evoked potential END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=1 article-no= start-page=85 end-page=90 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Photodecomposition of Ergosterol by Near-UV irradiation in the Plasma Membrane of the Yeast Rhodotorula minuta kn-title=長波長紫外光照射による酵母 Rhodotorula minuta 細胞膜エルゴステロールの分解 en-subtitle= kn-subtitle= en-abstract=酵母Rhodotorula minutaにおけるカロテノイドの光誘導合成および細胞膜の機能損傷に関わる初期光化学反応についての知見を得る目的で、長波長紫外光(UV-A光)による細胞膜エルゴステロールの分解を調べ、次の結果を得た。酵母菌体および菌体から調製した細胞膜調製品に長波長紫外光を照射すると吸収スペクトルに微細な変化が生じることを認めた。細胞膜調製品に生じた吸収スペクトルの変化は細胞膜エルゴステロールが光化学分解を受けることを予想させ、この予想はHPLC分析によって確かめられた。また、モデル系での実験によって、細胞膜中のエルゴステロールの光化学反応には特別な光受容体あるいは光増感剤は介在しておらず、エルゴステロール自身が光受容体であり反応基質となっていることが明らかになった。 kn-abstract=In search for primary photochemical reaction related to photoinduced carotenogenesis and photoinactivivation in yeast Rhodotorula minuta, the influence of near-UV radiation (300-400 nm) on ergosterol in the plasma membrane of the yeast. Irradiation by near-UV of intact cells and the plasma membrane preparation from the yeast caused changes in their absorption spectra. For the plasma membrane, difference spectra measured after irradiation of near-UV suggested the decomposition of ergosterol and the suggestion was proved by HPLC analysis. Experiments in model systems revealed that ergosterol itself was the photoreceptor in the photochemical reaction, and that there was not any other photoreceptor or photosensitizer which was related to photochemical reaction of ergosterol decomposition in the plasma membrane. en-copyright= kn-copyright= en-aut-name=NakaumaMakoto en-aut-sei=Nakauma en-aut-mei=Makoto kn-aut-name=中馬誠 kn-aut-sei=中馬 kn-aut-mei=誠 aut-affil-num=1 ORCID= en-aut-name=AramiShin-ichiro en-aut-sei=Arami en-aut-mei=Shin-ichiro kn-aut-name=荒見真一郎 kn-aut-sei=荒見 kn-aut-mei=真一郎 aut-affil-num=2 ORCID= en-aut-name=HadaMegumi en-aut-sei=Hada en-aut-mei=Megumi kn-aut-name=秦恵 kn-aut-sei=秦 kn-aut-mei=恵 aut-affil-num=3 ORCID= en-aut-name=NakagawaIchiro en-aut-sei=Nakagawa en-aut-mei=Ichiro kn-aut-name=中川一郎 kn-aut-sei=中川 kn-aut-mei=一郎 aut-affil-num=4 ORCID= en-aut-name=MurataYoshiyuki en-aut-sei=Murata en-aut-mei=Yoshiyuki kn-aut-name=村田芳行 kn-aut-sei=村田 kn-aut-mei=芳行 aut-affil-num=5 ORCID= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=農林水産省食品総合研究所 affil-num=3 en-affil= kn-affil=神戸大学理学部 affil-num=4 en-affil= kn-affil=九州農政局 affil-num=5 en-affil= kn-affil=岡山大学 affil-num=6 en-affil= kn-affil=岡山大学 en-keyword=Rhodotorula minuta kn-keyword=Rhodotorula minuta en-keyword=near-UV kn-keyword=near-UV en-keyword=ergosterol kn-keyword=ergosterol en-keyword=absorbance change kn-keyword=absorbance change END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=比較ゲノムハイブリダイゼーション法により解析された滑膜肉腫における染色体・遺伝子不安定性 kn-title=Chromosomal and genetic imbalances in synovial sarcoma detected by conventional and microarray comparative genomic hybridization en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaYasuko en-aut-sei=Nakagawa en-aut-mei=Yasuko kn-aut-name=中川寧子 kn-aut-sei=中川 kn-aut-mei=寧子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞性肺癌におけるXAGE-1の発現及び肺癌患者における抗体反応 kn-title=XAGE-1 Expression in Non-Small Cell Lung Cancer and Antibody Response in Patients en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川和彦 kn-aut-sei=中川 kn-aut-mei=和彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=84 cd-vols= no-issue= article-no= start-page=11 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=19900716 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=正徹「なぐさめ草」(松平文庫本)注釈(上) en-subtitle= kn-subtitle= en-abstract= kn-abstract=歌僧正徹（永徳元年～長禄三年）に「なぐさめ草」と称する紀行分が現存する。この作品は、東国旅行を思い立った正徹が、応永二十五年（一四一八）春三月末に都を浮かれ出て、やがて逢坂の関を越え、近江・美濃から尾張の黒田を経て、さらに清須に滞在、土地の翁や越の国へ旅する途中の童形達との談話や「源氏物語」談義などの様子を綴ったもので、同年六月頃までで閉じられている。「なぐさめ草」の伝本には、扶桑拾葉集本、これをもと系統と松平文庫本系統に大別される。前者に属する伝本には、扶桑拾葉集本、これももとに転写したとおぼしき群書類従本、祐徳神社寄托中川文庫本（「桑孤」収録 ）などのほか、やや系統を異にするが、早稲田大学図書館本も、この系統に属している。これに対して、松平文庫本系統は、島原市立図書館松平文庫本のみの孤本である。両系統を比較してみると、その本文異同は、書写階梯における誤写で生じたのではなく、大幅なものである。これは作者自身の推敲、追加などを考慮に入れなければ説明のつかない性格の異文で、両系統は初稿本と再稿本とに位置する伝本と思われる。この点に関しては、すでに拙稿「正徹の「なぐさめ草」の諸本と成立」(岡山大学教育学部研究集録、第四十九号、昭和五十三年七月)で実証したように、扶桑拾葉集本系統の方が初稿本の姿を伝え、松平文庫本系統は、その後、作者自身が用例の追加や表現の削除、推敲、和歌の差し換えなどの手を加えた再稿本とみなされる。今回行なう、この｢なぐさめ草｣の注釈は、再稿本の松平文庫本を底本に、扶桑拾葉集本系統との校合をもって校訂本文を作成し、その語釈、通釈を企図するものである。なお、島原市立図書館松平文庫本の｢なぐさめ草｣の書誌は以下の通りである。縦二七・五糎、横二〇・一糎。袋綴写本一冊。表紙は薄青色下地に唐草模様入り。題簽は左肩に｢慰草｣と貼付。本文料紙は斐紙。一面は一〇行書き、和歌は一首一行書き。墨付一八丁。江戸初期頃の書写本で、松平文庫本が多くの写本にある｢尚舎源忠房｣｢文庫｣の蔵書印で巻尾にある。なお、この｢慰草｣は、三浦三夫氏の手で翻刻されている(｢慰草(松平文庫本)｣、昭和四十四年三月刊。私家版)。 en-copyright= kn-copyright= en-aut-name=InadaToshinori en-aut-sei=Inada en-aut-mei=Toshinori kn-aut-name=稲田利徳 kn-aut-sei=稲田 kn-aut-mei=利徳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue= article-no= start-page=1 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=19901115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=正徹「なぐさめ草」(松平文庫本)注釈(中) en-subtitle= kn-subtitle= en-abstract= kn-abstract=歌僧正徹（永徳元年～長禄三年）に「なぐさめ草」と称する紀行分が現存する。この作品は、東国旅行を思い立った正徹が、応永二十五年（一四一八）春三月末に都を浮かれ出て、やがて逢坂の関を越え、近江・美濃から尾張の黒田を経て、さらに清須に滞在、土地の翁や越の国へ旅する途中の童形達との談話や「源氏物語」談義などの様子を綴ったもので、同年六月頃までで閉じられている。「なぐさめ草」の伝本には、扶桑拾葉集本、これをもと系統と松平文庫本系統に大別される。前者に属する伝本には、扶桑拾葉集本、これももとに転写したとおぼしき群書類従本、祐徳神社寄托中川文庫本（「桑孤」収録 ）などのほか、やや系統を異にするが、早稲田大学図書館本も、この系統に属している。これに対して、松平文庫本系統は、島原市立図書館松平文庫本のみの孤本である。両系統を比較してみると、その本文異同は、書写階梯における誤写で生じたのではなく、大幅なものである。これは作者自身の推敲、追加などを考慮に入れなければ説明のつかない性格の異文で、両系統は初稿本と再稿本とに位置する伝本と思われる。この点に関しては、すでに拙稿「正徹の「なぐさめ草」の諸本と成立」(岡山大学教育学部研究集録、第四十九号、昭和五十三年七月)で実証したように、扶桑拾葉集本系統の方が初稿本の姿を伝え、松平文庫本系統は、その後、作者自身が用例の追加や表現の削除、推敲、和歌の差し換えなどの手を加えた再稿本とみなされる。今回行なう、この｢なぐさめ草｣の注釈は、再稿本の松平文庫本を底本に、扶桑拾葉集本系統との校合をもって校訂本文を作成し、その語釈、通釈を企図するものである。なお、島原市立図書館松平文庫本の｢なぐさめ草｣の書誌は以下の通りである。縦二七・五糎、横二〇・一糎。袋綴写本一冊。表紙は薄青色下地に唐草模様入り。題簽は左肩に｢慰草｣と貼付。本文料紙は斐紙。一面は一〇行書き、和歌は一首一行書き。墨付一八丁。江戸初期頃の書写本で、松平文庫本が多くの写本にある｢尚舎源忠房｣｢文庫｣の蔵書印で巻尾にある。なお、この｢慰草｣は、三浦三夫氏の手で翻刻されている(｢慰草(松平文庫本)｣、昭和四十四年三月刊。私家版)。 en-copyright= kn-copyright= en-aut-name=InadaToshinori en-aut-sei=Inada en-aut-mei=Toshinori kn-aut-name=稲田利徳 kn-aut-sei=稲田 kn-aut-mei=利徳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue= article-no= start-page=1 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910715 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=正徹「なぐさめ草」(松平文庫本)注釈(下) en-subtitle= kn-subtitle= en-abstract= kn-abstract=一　本稿は正徹の紀行文『なぐさめ草』の注釈である。一　島原市立図書館松平文庫本「慰草」（一一六-四一）を底本とし、次の方針で校訂本文を作成した。(1）漢字・仮名を原則として通行の字体に替え、新字体のある漢字はそれを用い、濁点・句読点を施した。（2）底本の仮名を漢字に改めた場合は、表記を改めた本文の右側にもとの仮名を記した。漢字の読みを（）の内に示した所もある。（3）仮名遣いは原文のままとし、送り仮名を補った場合は（）内に記入した。また歴史的仮名遣いと一致しない場合は、（）を付して、歴史的仮名遣いを傍記した。ただし、仮名に漢字を宛てた場合は、これを省略した。（4）反復記号は底本のままとし、踊り字の場合は、もとの仮名に直し、右側に「ゝ」を付した。（5）底本の丁数は省略し、また本文も適宜改行した。（6）適当な箇所で区切り、番号と内容に即した見出しを付けた。一.校異・校訂本文は次の原則で作成した。（1）校合伝本としては、早稲田大学図書館本（略称-早）、扶桑拾葉集本（扶）、中川文庫本（中）、群書類従本（群）の四本を用いた。（2）異同のあるときは、その文字や表記の右肩に番号を付し、校異欄に異同を記した。ただし、さしたる意味もない独自異文や明らかな誤字などは、校異欄に省略したものがある。（3）底本の本文を他本で校訂したときは[]で示した。 en-copyright= kn-copyright= en-aut-name=InadaToshinori en-aut-sei=Inada en-aut-mei=Toshinori kn-aut-name=稲田利徳 kn-aut-sei=稲田 kn-aut-mei=利徳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=シアニン系感光色素のマクロフｧージに及ぼす作用と癌治療への応用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川美典 kn-aut-sei=中川 kn-aut-mei=美典 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=腎移植長期生着症例における免疫状態の解析 kn-title=Analysis of the Immune Status in the Recipients with Long-Term Well-Functioning Kidneys Allografts en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川和彦 kn-aut-sei=中川 kn-aut-mei=和彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=DNAの塩基欠落部位修復因子とともに精製されたマウス44kDa核タンパク質のcDNAクローニング, 一次構造解析および発現 kn-title=cDNA cloning, sequence analysis and expression of a mouse nuclear 44 kDa protein copurified with DNA repair factors for acid-depurinated DNA en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川雄公 kn-aut-sei=中川 kn-aut-mei=雄公 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肝組織ならびに血清中におけるC型肝炎ウｨルスのマイナス鎖リポ核酸の検出 kn-title=Detection of the 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en-article= kn-article= en-subject= kn-subject= en-title= kn-title=赤血球内Bile Pigment Precursorsに関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川昌壮 kn-aut-sei=中川 kn-aut-mei=昌壮 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=19690331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=接触アレルギーの担体に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川昌次郎 kn-aut-sei=中川 kn-aut-mei=昌次郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒト大腸癌におけるDAFの多様な発現 kn-title=Polymorphic expression of decay-accelerating factor in human colorectal cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川昌浩 kn-aut-sei=中川 kn-aut-mei=昌浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1967 dt-pub=19670331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=アデノウｨルス12型の発癌に関する病理組織学的研究 特に腹腔内に於ける腫瘍芽の分布について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川潤 kn-aut-sei=中川 kn-aut-mei=潤 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19681231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=胸部大動脈手術に関する実験的研究 とくに大動脈瘤を対象として en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川準平 kn-aut-sei=中川 kn-aut-mei=準平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1972 dt-pub=19720630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ステロ胆汁酸および胆汁アルコールに関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川俊彦 kn-aut-sei=中川 kn-aut-mei=俊彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=肝蓄積性を有するヒドロキシルラジカルスカベンジャーEPC-K1のブタ温阻血ドナー肝摘出前投与の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川秀和 kn-aut-sei=中川 kn-aut-mei=秀和 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=エンドセリン-1の脈絡膜血管に対する作用-第2報インドシアニングリーン蛍光造影による観察- en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川秀樹 kn-aut-sei=中川 kn-aut-mei=秀樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=19950325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=組織内照射加温によるサル正常脳組織への急性期における影響 Magnetic Resonance Imaging 上の変化と温熱による血液脳関門への影響 kn-title=Acute Effects of Interstitial Hyperthermia on Normal Monkey Brain Magnetic Resonance Imaging Appearance and Effects on Blood-Brain Barrier en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川実 kn-aut-sei=中川 kn-aut-mei=実 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=19901231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=好塩基球の反応性に関する研究 第1編 抗原,抗ヒト IgE 刺激時の好塩基球の経時的形態的変化とヒスタミン遊離 第2編 Ca. ionophore A23187 刺激時の好塩基球の経時的形態的変化とヒスタミン遊離 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= 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en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川雅博 kn-aut-sei=中川 kn-aut-mei=雅博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19681231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=分光光度法による人血液カタラーゼ活性の定量および低力タラーゼ血液症のスクリーニング法について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川嘉人 kn-aut-sei=中川 kn-aut-mei=嘉人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=1 article-no= start-page=113 end-page=122 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Investigation of Proteins Produced by Porcine Oviduct Epithelial Cells Cultured in a Serum-free Medium. kn-title=無血清培養ブタ卵管上皮細胞における産生タンパク質の探求 en-subtitle= kn-subtitle= en-abstract= kn-abstract=本研究ではブタ卵管上皮細胞の無血清培養法を検討し,この培養法によってブタの卵管上皮細胞から産生されるタンパク質の解析と培養上清中の高分子画分の細胞増殖活性を探索した. 未成熟のブタの卵管をEDTAとコラーゲナーゼで処理して,上皮細胞を分離した,無血清培地にはDMEM/Ham'sF12の1:1混合液にインスリン,トランスフェリン,亜セレン酸ナトリウム,ヒドロコルチゾン,レチノール,硫酸ストレプトマイシン,およびペニシリンを添加したものを用いた.卵管細胞は培養6日目には単層コンフルーエントの状態に達し,この状態は2週間保持された.また,電子顕微鏡観察の結果,培養細胞には上皮細胞の特徴である徴絨毛とスポットデスモゾームが認められ,上皮細胞と判定された.初代培養卵管上皮細胞の凍結保存を試み,10% DMSOを含む凍結用培地に0.1% メチルセルロースを添加すると融解後に高い生存率が得られた. 培養6日目から8日目まで10-6MのE2を培地に添加すると培養期間は2週間から3週間へと延長された.しかし,培養上清をSDS-電気泳動によって解析した結果,エストロジェン依存タンパクバンドは見いだせなかった. ブタの卵管膨大部と峡部の上皮細胞を別々に培養した結果,E2の添加によってそれぞれの細胞において培養期間の延長が認められた.さらに,膨大部と峡部細胞の培養上清の電気泳動の結果,タンパクバンドの相違がみられた. 卵管膨大部と峡部の上皮細胞から産生される10KDa以上の高分子画分の細胞増殖活性をブタ卵管峡部培養細胞のコロニー形成によって調べた.それぞれの培養上清中の高分子画分を10% 血清加培地に加えて検定培地とした.その結果,培養5日後に対照とした10% 血清区のコロニー形成率は極めて低く(2% ),卵管峡部の産生物質を含む培地で19% ,卵管膨大部画分を含む培地では33% であり膨大部の細胞増殖活性が最も高かった. この研究から,卵管膨大部と峡部細胞から細胞増殖因子が生産・放出されること,ならびに両者の活性に違いのあることが明らかにされた。 en-copyright= kn-copyright= en-aut-name=YuharaMasataka en-aut-sei=Yuhara en-aut-mei=Masataka kn-aut-name=湯原正高 kn-aut-sei=湯原 kn-aut-mei=正高 aut-affil-num=1 ORCID= en-aut-name=NakagawaYutaka en-aut-sei=Nakagawa en-aut-mei=Yutaka kn-aut-name=中川豊 kn-aut-sei=中川 kn-aut-mei=豊 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=小野薬品工業株式会社福井安全性研究所 END