大脳皮質における燐酸代謝に関する研究 第1編 真正癲癇および非癲癇患者大脳皮質の燐酸代謝について

Phosphoric acid metabolism in the cerebral cortex of epileptic patients, on whom corticoectomy was performed in this department, was studied in vitro by radioisotope tracer method, in comparison with that of the normal cerebral cortex obtained from non-epileptic patients. Brain homogenate was incubated with (32)P-phosphoric acid and glucose at 38°C, then fractionized into inorganic, acid soluble-organic, lipid. nucleic acid and phosphoprotein fraction, according to Schneider's method after 1, 3, 6, 12 and 24 hours of incubation and the radioactivity of each fraction was measured with Geiger-Müller counter. The results were as follows: 1) The rate of (32)P incorporation into acid soluble-organic, lipid, nucleic acid and phosphoprotein fraction in homogenate of epileptic patients was accelerated as compared with that of non-epileptics, but 2) no significant difference was observed in the accelerating ratio in each fraction.