result 20704 件
| Author | Furumatsu, Takayuki| Matsumoto, Emi| Kanazawa, Tomoko| Fujii, Masataka| Lu, Zhichao| Kajiki, Ryotaro| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2013-05-31 |
| Publication Title | Journal of Biomechanics |
| Volume | volume46 |
| Issue | issue9 |
| Content Type | Journal Article |
| Author | Inouye, N.| Maeda, T.| Mitsuhata, K.| |
|---|---|
| Published Date | 1982-11 |
| Publication Title | 農学研究 |
| Volume | volume60 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| Author | 大原農業研究所| |
|---|---|
| Published Date | 1979-12 |
| Publication Title | 農学研究 |
| Volume | volume58 |
| Issue | issue3-4 |
| Content Type | Departmental Bulletin Paper |
| Author | Takahashi, R.| Hayashi, J.| Moriya, I.| |
|---|---|
| Published Date | 1979-09 |
| Publication Title | 農学研究 |
| Volume | volume58 |
| Issue | issue2 |
| Content Type | Departmental Bulletin Paper |
| Author | Nakagawa, K.| |
|---|---|
| Published Date | 1979-09 |
| Publication Title | 農学研究 |
| Volume | volume58 |
| Issue | issue2 |
| Content Type | Departmental Bulletin Paper |
| Author | Muramoto, S.| |
|---|---|
| Published Date | 1979-03 |
| Publication Title | 農学研究 |
| Volume | volume58 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| Author | Muramoto, S.| |
|---|---|
| Published Date | 1979-03 |
| Publication Title | 農学研究 |
| Volume | volume58 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| Author | Maitani, T.| |
|---|---|
| Published Date | 1979-03 |
| Publication Title | 農学研究 |
| Volume | volume58 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| Author | Yamashita, T.| Kanehisa, K.| |
|---|---|
| Published Date | 1979-03 |
| Publication Title | 農学研究 |
| Volume | volume58 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| Author | Konishi, T.| |
|---|---|
| Published Date | 1979-03 |
| Publication Title | 農学研究 |
| Volume | volume58 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| Author | Kawasaki, T.| Moritsugu, M.| |
|---|---|
| Published Date | 1979-03 |
| Publication Title | 農学研究 |
| Volume | volume57 |
| Issue | issue3-4 |
| Content Type | Departmental Bulletin Paper |
| Author | 大原農業研究所| |
|---|---|
| Published Date | 1979-03 |
| Publication Title | 農学研究 |
| Volume | volume57 |
| Issue | issue3-4 |
| Content Type | Departmental Bulletin Paper |
| Author | Muramoto, S.| |
|---|---|
| Published Date | 1978-03 |
| Publication Title | 農学研究 |
| Volume | volume57 |
| Issue | issue2 |
| Content Type | Departmental Bulletin Paper |
| Author | Baba, I.| |
|---|---|
| Published Date | 1978-03 |
| Publication Title | 農学研究 |
| Volume | volume57 |
| Issue | issue2 |
| Content Type | Departmental Bulletin Paper |
| Author | Nishida, F.| Kasahara, Y.| |
|---|---|
| Published Date | 1978-02 |
| Publication Title | 農学研究 |
| Volume | volume57 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| Author | Kobayashi, J.| Morii, F.| Muramoto, S.| Nakashima, S.| Urakami, Y.| Nishizaki, H.| Teraoka, H.| Nagao, N.| |
|---|---|
| Published Date | 1978-02 |
| Publication Title | 農学研究 |
| Volume | volume57 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| JaLCDOI | 10.18926/AMO/51069 |
|---|---|
| FullText URL | 67_4_245.pdf |
| Author | Araki, Tohru| Monden, Koichi| Araki, Motoo| |
| Abstract | A crossover study was conducted to identify the best α1-adrenoceptor (α1AR) antagonist for individual patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). One hundred thirteen patients (mean age 70.8 years) were enrolled. All patients met BPH clinical study guidelines. Seven agents were utilized:tamsulosin 0.2mg, silodosin 8mg, urapidil 60mg, naftopidil 50mg, prazosin 1mg, terazosin 2mg, and doxazosin 1mg. Patients were initially prescribed tamsulosin or silodosin for a week and then urapidil for a week. Two weeks later, they were prescribed the better of the 2 agents for a week and a new agent for the next week. This cycle was repeated until all 7 agents were tested. Efficacy was evaluated with the International Prostate Symptom Score. The agent rankings were doxazosin (25 [22%]), silodosin (22 [19%]), urapidil (19 [17%]), naftopidil (17 [15%]), terazosin (12 [11%]), tamsulosin (11 [10%]), prazosin (7 [6%]). Only 12 patients (11%) changed agents after the crossover study was completed. The major reason was adverse events (83%). We found that each of the 7 α1AR antagonists has its own supporters. Further, the one-week crossover study was useful in identifying the best agent for the treatment of each individual with LUTS. |
| Keywords | alpha-1 blockers alpha1-adrenoceptor antagonists lower urinary tract symptoms benign prostatic hyperplasia crossover study |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-08 |
| Volume | volume67 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 245 |
| End Page | 251 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23970323 |
| Web of Science KeyUT | 000323470100006 |
| JaLCDOI | 10.18926/AMO/51064 |
|---|---|
| FullText URL | 67_4_203.pdf |
| Author | Ohuchi, Hideyo| |
| Abstract | A central issue of evolutionary developmental biology is how the eye is diverged morphologically and functionally. However, the unifying mechanisms or schemes that govern eye diversification remain unsolved. In this review, I first introduce the concept of evolutionary developmental biology of the eye with a focus on photoreception, the fundamental property of retinal cells. Second, I summarize the early development of vertebrate eyes and the role of a homeobox gene, Lhx1, in subdivision of the retina into 2 domains, the neural retina and retinal pigmented epithelium of the optic primordium. The 2 retinal domains are essential components of the eye as they are found in such prototypic eyes as the extant planarian eye. Finally, I propose the presence of novel retinal cell subtypes with photosensory functions based on our recent work on atypical photopigments (opsins) in vertebrates. Since human diseases are attributable to the aberration of various types of cells due to alterations in gene expression, understanding the precise mechanisms of cellular diversification and unraveling the molecular profiles of cellular subtypes are essential to future regenerative medicine. |
| Keywords | eye development evolution opsin photoreceptor |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-08 |
| Volume | volume67 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 203 |
| End Page | 212 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23970318 |
| Web of Science KeyUT | 000323470100001 |
| Author | Inouye, N.| Mitsuhata, K.| |
|---|---|
| Published Date | 1978-02 |
| Publication Title | 農学研究 |
| Volume | volume57 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| Author | Nakagawa, K.| Hattori, K.| |
|---|---|
| Published Date | 1977-03 |
| Publication Title | 農学研究 |
| Volume | volume56 |
| Issue | issue4 |
| Content Type | Departmental Bulletin Paper |
