result 781 件
| JaLCDOI | 10.18926/AMO/55202 |
|---|---|
| FullText URL | 71_3_201.pdf |
| Author | Matsuda, Miwa| Sasaki, Aiko| Shimizu, Keiko| Kamada, Yasuhiko| Noguchi, Soichi| Hiramatsu, Yuji| Nakatsuka, Mikiya| |
| Abstract | Vascular dysfunction has been reported in women with recurrent pregnancy loss (RPL). We investigated the severity of vascular dysfunction in non-pregnant women with RPL and its correlation with anti-heat shock protein (HSP) antibodies that are known to induce arteriosclerosis. We measured the serum anti-HSP60 antibodies, anti-HSP70 antibodies, and anti-phospholipid antibodies (APA) in 68 women with RPL and 29 healthy controls. Among the women with RPL, 14 had a diagnosis of antiphospholipid syndrome (APS), and in the remaining 54, the causes for RPL were unexplained. Compared to the controls, the brachial-ankle pulse wave velocity (baPWV), carotid augmentation index (cAI), and uterine artery pulsatility index (PI) were all significantly higher in the women with both APS and unexplained RPL. Compared to the controls, the anti-HSP60 antibody levels were significantly higher in the APA-positive group of women with unexplained RPL, and the anti-HSP70 antibody levels were significantly higher in APS and APA-positive group of women with unexplained RPL. However, the anti-HSP60 and anti-HSP70 antibody levels did not correlate with the values of baPWV or cAI. Our results demonstrated anti-HSP60 and anti-HSP70 antibodies are increased in women with unexplained RPL. Further studies are needed to elucidate the roles of anti-HSP antibodies and their pathophysiology in unexplained RPL. |
| Keywords | recurrent pregnancy loss autoantibody heat shock protein pulse wave velocity arterial stiffness |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-06 |
| Volume | volume71 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 201 |
| End Page | 208 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28655939 |
| FullText URL | J_Comp_Neurol_525_7_1586.pdf |
|---|---|
| Author | Tamura, Kei| Kobayashi, Yasuhisa| Hirooka, Asuka| Takanami, Keiko| Oti, Takumi| Jogahara, Takamichi| Oda, Sen-ichi| Sakamoto, Tatsuya| Sakamoto, Hirotaka| |
| Keywords | RRID AB_2060157 RRID: AB_2571636 RRID: AB_626757 Suncus murinus (suncus) gastrin-releasing peptide male reproductive function sexual dimorphism spinal cord |
| Note | This is the peer reviewed version of the following article: Tamura K. Kobayashi Y. Hirooka A. et al. Identification of the sexually dimorphic gastrin-releasing peptide system in the lumbosacral spinal cord that controls male reproductive function in the mouse and Asian house musk shrew (Suncus murinus). J Comp Neurol. 2017;525:1601–1613. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.| 2018年5月公開予定| |
| Published Date | 2017-05-01 |
| Publication Title | Journal of Comparative Neurology |
| Volume | volume525 |
| Issue | issue7 |
| Publisher | Wistar Institute of Anatomy and Biology |
| Start Page | 1586 |
| End Page | 1598 |
| ISSN | 0021-9967 |
| NCID | AA00695917 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 27804131 |
| DOI | 10.1002/cne.24138 |
| Web of Science KeyUT | 000397559700004 |
| Related Url | https://doi.org/10.1002/cne.24138 |
| FullText URL | K0005537_abstract_review.pdf K0005537_fulltext_1.pdf K0005537_fulltext_2.pdf |
|---|---|
| Author | Sunagawa, Masanori| |
| Published Date | 2017-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5537号 |
| Granted Date | 2017-03-24 |
| Thesis Type | Doctor of Philosophy in Science |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005535_abstract_review.pdf K0005535_fulltext .pdf |
|---|---|
| Author | Bui Thi Tra Mi| |
| Published Date | 2017-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5535号 |
| Granted Date | 2017-03-24 |
| Thesis Type | Doctor of Philosophy in Agriculture |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005534_abstract_review.pdf K0005534_fulltext.pdf |
|---|---|
| Author | Okudaira, Yuichi| |
| Published Date | 2017-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5534号 |
| Granted Date | 2017-03-24 |
| Thesis Type | Doctor of Philosophy |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005505 abstract_review.pdf K0005505_summary.pdf K0005505_fulltext.pdf K0005505_other.pdf |
|---|---|
| Author | Tanimura, Hiroshi| |
| Published Date | 2017-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5505号 |
| Granted Date | 2017-03-24 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005493 abstract_review.pdf K0005493_summary.pdf K0005493_fulltext.pdf K0005493_other.pdf |
|---|---|
| Author | Kunitomo, Masayoshi| |
| Published Date | 2017-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5493号 |
| Granted Date | 2017-03-24 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005468_abstract_review.pdf K0005468_summary.pdf K0005468_fulltext.pdf K0005468_others.pdf |
|---|---|
| Author | Kakio, Yuki| |
| Published Date | 2017-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5468号 |
| Granted Date | 2017-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005438_abstract_review.pdf K0005438_summary.pdf K0005438_fulltext.pdf |
|---|---|
| Author | Matsuda, Miwa| |
| Published Date | 2017-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5438号 |
| Granted Date | 2017-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/54989 |
|---|---|
| FullText URL | 71_2_187.pdf |
| Author | Takamoto, Atsushi| Araki, Motoo| Wada, Koichiro| Sugimoto, Morito| Kobayashi, Yasuyuki| Sasaki, Katsumi| Watanabe, Toyohiko| Nasu, Yasutomo| |
| Abstract | We report the case of a 58-year-old Japanese man with bilateral synchronous renal cell carcinoma (RCC). The diameters of the right and left tumors were 56 and 69 mm, respectively. Both tumors were endophytic. Cryoablation with prophylactic embolization was performed for the left tumor, and 1 month later, a right open partial nephrectomy was performed. No recurrence was observed during a 16-month follow-up, and the serum creatinine level has been stable. The prognosis of bilateral synchronous RCC is better than that of dialysis patients. The novel approach of combining cryoablation and partial nephrectomy can achieve good cancer control and renal function in bilateral RCC. |
| Keywords | cryoablation multiple renal masses nephron-sparing surgery renal cell carcinoma synchronous multiple primary |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 187 |
| End Page | 190 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420902 |
| JaLCDOI | 10.18926/AMO/54981 |
|---|---|
| FullText URL | 71_2_127.pdf |
| Author | Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Tanabe, Shunsuke| Kuroda, Shinji| Kagawa, Shunsuke| Katsui, Kuniaki| Katayama, Norihisa| Kanazawa, Susumu| Fujiwara, Toshiyoshi| |
| Abstract | Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified. |
| Keywords | esophageal cancer radiation therapy high-risk patient |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 127 |
| End Page | 133 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420894 |
| JaLCDOI | 10.18926/AMO/54979 |
|---|---|
| FullText URL | 71_2_113.pdf |
| Author | Morikawa Tatsuya| Okabayashi Takehiro| Shima, Yasuo| Sumiyoshi, Tatsuaki| Kozuki, Akihito| Saisaka, Yuichi| Tokumaru, Teppei| Sui, Kenta| Iwata, Jun| Matsumoto, Manabu| Morita, Sojiro| Nishioka, Yutaka| |
| Abstract | Some clinicians have proposed a relationship between gallbladder (GB) cancer and adenomyomatosis (ADM) of the gallbladder, although the latter condition is not considered to have malignant potential. We retrospectively reviewed the surgical pathology database of patients who underwent resection for ADM of the gallbladder at our institution from March 2005 to May 2015. In total, 624 patients underwent surgical resection of the gallbladder with Rokitansky-Aschoff sinuses. Of these cases, 93 were pathologically diagnosed with ADM of the gallbladder, with 44 (47.3%) classified macroscopically as fundal-type ADM, 26 (28.0%) as segmental type, and 23 (24.7%) as diffuse-type ADM. In 3 of the 93 (3.2%) resected specimens, early-stage GB carcinoma was detected, although preoperative imaging did not suggest a malignant neoplasm of the gallbladder in any of these patients. GB cancer subsequently developed in the mucosa of the fundal compartment distal to the annular stricture of the segmental-type ADM in 2 of these patients and against the background of the fundal-type ADM in 1 patient. This study revealed the difficulty of early diagnosis of primary GB cancer in the setting of concurrent ADM, and clinicians should be aware of this frequent coexistence. |
| Keywords | adenomyomatosis gallbladder carcinoma Rokitansky-Aschoff sinuses surgery carcinogenesis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 113 |
| End Page | 118 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420892 |
| FullText URL | K0005437_abstract_review.pdf K0005437_fulltext.PDF |
|---|---|
| Author | Funakubo, Narumi| |
| Published Date | 2016-12-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5437号 |
| Granted Date | 2016-12-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005426_abstract_review.pdf K0005426_fulltext.pdf |
|---|---|
| Author | Nishitani, Seishi| |
| Published Date | 2016-12-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5426号 |
| Granted Date | 2016-12-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Author | Iwasaki, Yuka| Nishiuchi, Rituo| Aoe, Michinori| Takahashi, Takahide| Watanabe, Hirokazu| Tokorotani, Chiho| Kikkawa, Kiyoshi| Shimada, Akira| |
|---|---|
| Published Date | 2017-02 |
| Publication Title | Acta Medica Okayama |
| Volume | volume71 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/54829 |
| JaLCDOI | 10.18926/AMO/54815 |
|---|---|
| FullText URL | 70_6_503.pdf |
| Author | Kanazawa, Yui| Yamashita, Yuka| Fujiwara, Mitsuhiro| Muraoka, Michiko| Washio, Kana| Kanamitsu, Kiichiro| Ishida, Hisashi| Nakano, Takae| Yamada, Miho| Horibe, Keizo| Tanaka, Takehiro| Yoshino, Tadashi| Shimada, Akira| |
| Abstract | Childhood anaplastic large cell lymphoma (ALCL) accounts for approx. 10–30 of cases of non-Hodgkin lymphoma, and the ALCL99 study reported 60–75 disease-free survival; however, a relatively high relapse rate was observed (25–30 ). We report 2 patients with Stage III ALCL who relapsed 6–18 months after the end of ALCL99 chemotherapy. A retrospective molecular analysis identified the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) fusion gene in the first diagnostic bone marrow samples taken from both patients. However, antibodies against the ALK protein appeared to be relatively low in the serum of both patients (×100 and ×750). An increase in chemotherapy intensity may be beneficial if Stage III ALCL patients are shown to be NPM-ALK chimera-positive in the first diagnostic bone marrow sample. |
| Keywords | ALCL NPM-ALK fusion lymphoma |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-12 |
| Volume | volume70 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 503 |
| End Page | 506 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28003677 |
| Author | Faculty of Agriculture, Okayama University| |
|---|---|
| Published Date | 2017-02-01 |
| Publication Title | Scientific Reports of the Faculty of Agriculture, Okayama University |
| Volume | volume106 |
| Content Type | Others |
| FullText URL | O0004464_abstract_review.pdf O0004464_fulltext.pdf |
|---|---|
| Author | Takai, Takafumi| |
| Published Date | 2016-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4464号 |
| Granted Date | 2016-09-30 |
| Thesis Type | Doctor of Philosophy in Agriculture |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005419_abstract_review.pdf K0005419_fulltext.pdf |
|---|---|
| Author | FERRÉ PUJOL Pilar| |
| Published Date | 2016-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5419号 |
| Granted Date | 2016-09-30 |
| Thesis Type | Doctor of Philosophy |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/54596 |
|---|---|
| FullText URL | 70_5_377.pdf |
| Author | Kawakami, Yoshio| Katayama, Takashi| Kishida, Masayuki| Oda, Wakako| Inoue, Yasuro| |
| Abstract | A 71-year-old man presented with a high fever, polyarthralgia, petechiae and palpable purpura accompanied by livedoid change on his legs and feet. Histopathological findings of the purpura revealed perivascular infiltration of neutrophils, mononuclear cells, and nuclear debris, and extravasation of red cells mainly in the upper dermis: all signs consistent with leukocytoclastic vasculitis. Small vessel thrombi, which are characteristic features of septic vasculopathy, were also observed. Direct immunofluorescence showed negative results. Blood culture revealed the growth of gram-negative bacilli. Subsequently, 16S rRNA sequencing of DNA confirmed the organism as Streptobacillus moniliformis, which is the causative pathogen of rat-bite fever. He had frequently encountered wild rats in his house although there was no evidence of rat bite on his body. Empiric therapy with intravenous administration of ceftriaxone in combination with azithromycin hydrate led to a prompt resolution of the symptoms. Precise history-taking related to contact with rats and detection of skin eruptions suggestive of leukocytoclastic vasculitis on the extremities, especially on the feet, can be clues to Streptobacillus moniliformis infection. Familiarity with its cutaneous features is important for early diagnosis; the evidence herein may also help in understanding its underlying pathogenesis. |
| Keywords | livedo vasculitis rat bite fever polyarteritis nodosa septic vasculopathy |
| Amo Type | Case Reports |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 377 |
| End Page | 381 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777430 |
| Web of Science KeyUT | 000388098700007 |
