| ID | 14261 |
| Eprint ID | 14261
|
| FullText URL | |
| Title Alternative | The effect of human superoxide dismutase on reperfusion injury in clinical cases
|
| Author |
Takata, Kouji
|
| Abstract | In valve replacement surgery, human superoxide dismutase (h-SOD) was administered just before reperfusion, and the effect of h-SOD on reperfusion injury was studied. Release of cardiac enzymes (CPK-MB and HBD), increase of left ventricular volume, and recovery rate of cardiac function were measured. The release of the enzymes during 60 minutes after reperfusion in the group receiving h-SOD (3mg/kg) was less than that of the control (without h-SOD)group (p<0.01). Myocardial edema (volume increase) was also reduced by h-SOD (1mg/kg or 3mg/kg : p<0.01). Recovery of cardiac function after reperfusion of the h-SOD group was better than that of the control group. In conclusion, h-SOD can protect the myocardium from reperfusion injury and accelerate the rate of recovery of cardiac function after global ischemia.
|
| Keywords | 再灌流障害
h-SOD
心筋浮腫
心筋保護
|
| Note | 原著
|
| Published Date | 1992-12
|
| Publication Title |
岡山医学会雑誌
|
| Publication Title Alternative | Journal of Okayama Medical Association
|
| Volume | volume104
|
| Issue | issue11-12
|
| Publisher | 岡山医学会
|
| Publisher Alternative | Okayama Medical Association
|
| Start Page | 1127
|
| End Page | 1134
|
| ISSN | 0030-1558
|
| NCID | AN00032489
|
| Content Type |
Journal Article
|
| Official Url | https://www.jstage.jst.go.jp/article/joma1947/104/11-12/104_11-12_1127/_article/-char/ja/
|
| Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
|
| language |
Japanese
|
| Copyright Holders | 岡山医学会
|
| File Version | publisher
|
| Refereed |
True
|
| Eprints Journal Name | joma
|
