result 819 件
| JaLCDOI | 10.18926/47025 |
|---|---|
| FullText URL | mfe_36_2_051_060.pdf |
| Author | Hikida, Masaki| Magari, Masaki| Nakayama, Yasunori| Kanayama, Naoki| Ohmori, Hitoshi| |
| Abstract | A population of peripheral B cells have been shown to express recombination activating gene products, RAG-1 and RAG-2, which are considered to be involved in revising the B cell antigen receptor (BCR) in the periphery. BCR engagement has been reported to turn off RAG expression in peripheral B cells, whereas the same treatment has an opposite effect in immature B cells in the bone marrow. In contrast to receptor editing that is involved in the removal of autoreactivity in immature B cells, it has been shown that secondary V(D)J rearrangement in peripheral B cells, termed receptor revision, contributes to affinity maturation of antibodies. Here, we show that RAG-2 expression in murine splenic B cells was abrogated by the coligation of BCR with complement receptors (CD21/CD35) much more efficiently than by the engagement of BCR alone. On the other hand, the same coligation augmented proliferation of anti-CD40-stimulated B cells. Consistent with these observations, RAG-2 expression was lower in the draining lymph nodes of the quasi-monoclonal mice when they were immunized with a high-affinity antigen than with a low-affinity one. These findings suggest a crucial role for CD21/CD35 in directing the conservation or the revision of BCRs in peripheral B cells. |
| Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
| Published Date | 2002-03 |
| Volume | volume36 |
| Issue | issue2 |
| Start Page | 51 |
| End Page | 60 |
| ISSN | 0475-0071 |
| language | English |
| File Version | publisher |
| NAID | 80015582223 |
| JaLCDOI | 10.18926/47005 |
|---|---|
| FullText URL | mfe_36_1_117_121.pdf |
| Author | Shirosaki, Yuki| Tsuru, Kanji| Hayakawa, Satoshi| Osaka, Akiyoshi| Takashima, Seisuke| |
| Abstract | γ-Methacryloxypropyltrimethoxysilane (γ-MPS) was grafted to silicone due to emulsion polymerization to induce Si-OH groups, in order to provide silicone with bioactivity spontaneous deposition of apatite in body fluid and to improve cytocompatibility. Apatite deposited on the grafted silicone within 7 days of soaking in 1.5 times as concentrated as the Kokubo solution. Osteoblastic cells (MC3T3-E1) were cultured on the specimens up to 7 days. After 5 days of culture, the number of MC3T3-E1 cells on the grafted specimen was much greater than that on the original specimen. These results indicated that the biocompatibility of silicone elastomer was improved by the grafting γ-MPS. |
| Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
| Published Date | 2001-12 |
| Volume | volume36 |
| Issue | issue1 |
| Start Page | 117 |
| End Page | 121 |
| ISSN | 0475-0071 |
| language | English |
| File Version | publisher |
| NAID | 120003497031 |
| JaLCDOI | 10.18926/46955 |
|---|---|
| FullText URL | mfe_38_1-2_091_096.pdf |
| Author | Kanayama, Naoki| Yamakoshi, Kimi| Kiyomi, Masaaki| Magari, Masaki| Ohmori, Hitoshi| |
| Abstract | Generally, IgM antibodies (Abs) produced in a primary immune response show lower affinity for an inducing antigen (Ag) compared with the corresponding IgG Abs that are major switched isotypes formed in the secondary response. An IgM molecule is a pentamer with 10 Ag-binding sites that will contribute to an increase of avidity for an Ag. To estimate the contribution of the pentameric structure to the avidity of an IgM Ab, we generated IgM and IgG1 monoclonal Abs (mAbs) with identical V regions that are specific for 4-hydroxy-3-nitrophenylacetyl (NP) by in vitro class switching of B cells followed by the cell fusion with a mouse myeloma cell line. Compared with an anti-NP IgG1 mAb, the corresponding IgM mAb showed much higher avidity for NP-conjugated bovine serum albumin, which was drastically reduced after being dissociated into monomers. |
| Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
| Published Date | 2004-03 |
| Volume | volume38 |
| Issue | issue1-2 |
| Start Page | 91 |
| End Page | 96 |
| ISSN | 0475-0071 |
| language | English |
| File Version | publisher |
| NAID | 80017001822 |
| JaLCDOI | 10.18926/46946 |
|---|---|
| FullText URL | mfe_38_1-2_001_004.pdf |
| Author | Sakakibara, Akira| Kanadani, Teruto| |
| Abstract | The relationship between occurrence of serration and reversion heat treatment was studied by tensile test on Al-10mass%Zn alloy. Serration was observed for the furnace cooled specimen, but not for the as-quenched one and the shortly aged one, which result is difficult to be interpreted by the Cottrell theory. The stress amplitude in the serration increased with increasing the time of annealing for reversion up to 10ks and then stayed at a constant value which might be interpreted by the Cottrell theory. The stress amplitude in the serration decreased with increasing the annealing temperature, which is contrary to the prediction by the Cottrell theory. The specimen directly annealed without aging and the one annealed after aging agreed well with each other in the tensile strength and the stress amplitude in the serration, which suggests solute clusters as the cause of serration. |
| Publication Title | Memoirs of the Faculty of Engineering, Okayama University |
| Published Date | 2004-03 |
| Volume | volume38 |
| Issue | issue1-2 |
| Start Page | 1 |
| End Page | 4 |
| ISSN | 0475-0071 |
| language | English |
| File Version | publisher |
| NAID | 80016785932 |
| Author | Kitamatsu, Mizuki| Takahashi, Akiko| Ohtsuki, Takashi| Sisido, Masahiko| |
|---|---|
| Published Date | 2010-12-18 |
| Publication Title | Tetrahedron |
| Volume | volume66 |
| Issue | issue51 |
| Content Type | Journal Article |
| Author | Kitamatsu, Mizuki| Kubo, Takanori| Matsuzaki, Rino| Endoh, Tamaki| Ohtsuki, Takashi| Sisido, Masahiko| |
|---|---|
| Published Date | 2009-07-01 |
| Publication Title | Bioorganic & Medicinal Chemistry Letters |
| Volume | volume19 |
| Issue | issue13 |
| Content Type | Journal Article |
| Author | Kitamatsu, Mizuki| Kurami, Shunsuke| Ohtsuki, Takashi| Sisido, Masahiko| |
|---|---|
| Published Date | 2011-01 |
| Publication Title | Bioorganic & Medicinal Chemistry Letters |
| Volume | volume21 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Otani, Shinji| |
|---|---|
| Published Date | 2011-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Nakamura, Eri| |
|---|---|
| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Anabuki, Yuka| |
|---|---|
| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Aoyama, Hideki| |
|---|---|
| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Nishioka, Yasutaka| |
|---|---|
| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Sudarsono, Amang| |
|---|---|
| Published Date | 2011-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Abe, Nobuhiro| |
|---|---|
| Published Date | 2011-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/OER/42355 |
|---|---|
| Title Alternative | Economic System and Planning Process |
| FullText URL | oer_005_1_075_099.pdf |
| Author | Takemura, S.| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 1973-07-15 |
| Volume | volume5 |
| Issue | issue1 |
| Start Page | 75 |
| End Page | 99 |
| ISSN | 0386-3069 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002737738 |
| JaLCDOI | 10.18926/OER/42320 |
|---|---|
| Title Alternative | Logic of System and Fundamental Frame of Economic System |
| FullText URL | oer_008_1_001_015.pdf |
| Author | Takemura, S.| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 1976-08-10 |
| Volume | volume8 |
| Issue | issue1 |
| Start Page | 1 |
| End Page | 15 |
| ISSN | 0386-3069 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002737652 |
| JaLCDOI | 10.18926/OER/42302 |
|---|---|
| Title Alternative | Fundamental Frame of Economic System (II) |
| FullText URL | oer_009_1_082_102.pdf |
| Author | Takemura, S.| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 1977-07-15 |
| Volume | volume9 |
| Issue | issue1 |
| Start Page | 82 |
| End Page | 102 |
| ISSN | 0386-3069 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002737611 |
| JaLCDOI | 10.18926/OER/42130 |
|---|---|
| Title Alternative | On the Development of the Labour Market in the Southern Industrial Areas and its Influence on the Changes of the Farming Systems and the Organizations of Agriculture in the Mountainous and IIilly Districts of Okayama Prefecture 〔II〕 |
| FullText URL | oer_015_3_087_121.pdf |
| Author | Watanabe, Motoi| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 1983-11-30 |
| Volume | volume15 |
| Issue | issue3 |
| Start Page | 87 |
| End Page | 121 |
| ISSN | 0386-3069 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002737437 |
| JaLCDOI | 10.18926/OER/42123 |
|---|---|
| Title Alternative | On the Development of the Labour Market in the Soutern Industrial Areas and its Influence on the Changes of the Farming Systems and the Organizations of Agriculture in the Mountainous and Hilly District of Okayama Prefecture. 〔I〕 |
| FullText URL | oer_015_2_001_045.pdf |
| Author | Watanabe, Motoi| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 1983-09-10 |
| Volume | volume15 |
| Issue | issue2 |
| Start Page | 1 |
| End Page | 45 |
| ISSN | 0386-3069 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002737446 |
| JaLCDOI | 10.18926/OER/42033 |
|---|---|
| Title Alternative | Information System for Management Decision |
| FullText URL | oer_018_4_021_038.pdf |
| Author | Nishikado, Masami| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 1987-03-20 |
| Volume | volume18 |
| Issue | issue4 |
| Start Page | 21 |
| End Page | 38 |
| ISSN | 0386-3069 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002723019 |
