result 1175 件
| JaLCDOI | 10.18926/AMO/56866 |
|---|---|
| FullText URL | 73_3_235.pdf |
| Author | Horita, Masahiro| Nishida, Keiichiro| Hashizume, Kenzo| Sugimoto, Yoshihisa| Nasu, Yoshihisa| Nakahara, Ryuichi| Harada, Ryozo| Ozaki, Toshifumi| |
| Abstract | We investigated the prevalence of and risk factors for the progression of upper cervical lesions (UCLs) in patients with rheumatoid arthritis (RA). A retrospective analysis of 49 patients with RA (4 males, 45 females) was conducted. The UCLs included atlanto-axial subluxation and vertical subluxation. We investigated the clinical factors including the Disease Activity Score 28 based on C-reactive protein (DAS28-CRP) and the modified Health Assessment Questionnaire-Disability Index as well as radiographic changes between the baseline (at May 2010 to April 2013) and final follow-up. Forty patients (81.6%) were classified as the non-progressive group, and the other 9 patients (18.4%) comprised the progressive group. The progressive group’s final CRP values, baseline or final MMP-3 levels, DAS28-CRP, and rate of pre-existing lesions at baseline were all significantly higher than those of the non-progressive group (p=0.017, p=0.043, p=0.002, p=0.008, p<0.001, and p=0.008 respectively). A multivariate logistic regression analysis demonstrated that DAS28-CRP at baseline was a risk factor for radiographic progression (p=0.018, odds ratio: 2.54, 95% confidence interval: 1.17-5.51). Our findings indicate that higher disease activity might influence the progression of UCLs in patients with RA. |
| Keywords | rheumatoid arthritis upper cervical spine lesion risk factor radiological progression |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 235 |
| End Page | 240 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235971 |
| FullText URL | J_ClinMicrobiol_51_3_1040.pdf |
|---|---|
| Author | Naha, A.| Chowdhury, G.| Ghosh-Banerjee, J.| Senoh, M.| Takahashi, T.| Ley, B.| Thriemer, K.| Deen, J.| Seidlein, L. V.| Ali, S. M.| Khatib, A.| Ramamurthy, T.| Nandy, R. K.| Nair, G. B.| Takeda, Y.| Mukhopadhyay, A. K.| |
| Keywords | Vibrio cholerae ctxB Cholera PFGE |
| Note | This is an Accepted Manuscript of an article published by American Society for Microbiology| |
| Published Date | 2013-03 |
| Publication Title | Journal of Clinical Microbiology |
| Volume | volume51 |
| Issue | issue3 |
| Publisher | American Society for Microbiology |
| Start Page | 1040 |
| End Page | 1045 |
| ISSN | 00951137 |
| NCID | AA00695531 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 23325815 |
| DOI | 10.1128/JCM.03162-12 |
| Web of Science KeyUT | 000315121700055 |
| Related Url | isVersionOf https://doi.org/10.1128/JCM.03162-12 |
| JaLCDOI | 10.18926/AMO/56655 |
|---|---|
| FullText URL | 73_2_181.pdf |
| Author | Okamura, Tomoka| Washio, Yousuke| Yoshimoto, Junko| Tani, Kazumasa| Tsukahara, Hirokazu| Shimada, Akira| |
| Abstract | Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops fetalis (HF) show poor clinical outcomes. We report three infants with DS-TAM and HF who were treated with exchange transfusion (ET) followed by low-dose cytarabine (LD-CA). All of them survived without developing liver failure, acute leukemia, or other serious adverse events. Our results suggest that this combination treatment with ET and LD-CA would be safe, tolerable and effective as an novel approach for DS-TAM patients with HF. |
| Keywords | cytarabine Down syndrome exchange transfusion hydrops fetalis transient abnormal myelopoiesis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-04 |
| Volume | volume73 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 181 |
| End Page | 188 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31015754 |
| JaLCDOI | 10.18926/AMO/56647 |
|---|---|
| FullText URL | 73_2_117.pdf |
| Author | Yamasaki, Yukie| Tamiya, Nanako| Yamamoto, Hideki| Miyaishi, Satoru| |
| Abstract | According to the World Health Organization’s World Report, approx. 950,000 children and young people < 18 years old die from an injury each year, and unintentional injury deaths account for a large portion of these cases. Here we used medico-legal documents to epidemiologically analyze the cases of unintentional injury deaths among children < 5 years old in Okayama Prefecture, Japan from 2001 to 2015. Age, sex, manner/cause of death, and various circumstances of the incident were investigated. There were 73 unintentional injury deaths during the study period. Drowning (n=29), suffocation (n=24), and transport accidents (n=13) were the major categories of unintentional injury deaths. Twenty-two cases (30.1%) were autopsied. Differences in the characteristics of the unintentional injury deaths by age were observed. Information which cannot be obtained from Vital Statistics was available from medico-legal documents, and detailed characteristics of unintentional injury deaths among children < 5 years old were elucidated. Investigating medico-legal information is one of the meaningful measures for the prevention of unintentional injury deaths among children in Japan. |
| Keywords | child death unintentional injury prevention medico-legal document |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-04 |
| Volume | volume73 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 117 |
| End Page | 125 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31015746 |
| Title Alternative | The 2017 Incentive Award of the Okayama Medical Association in General Medical Science (2017 Yuuki Prize) |
|---|---|
| FullText URL | 130_113.pdf |
| Author | Wake, Hidenori| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-12-03 |
| Volume | volume130 |
| Issue | issue3 |
| Start Page | 113 |
| End Page | 115 |
| ISSN | 0030-1558 |
| Related Url | references https://doi.org/10.1016/j.ebiom.2016.06.003 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.113 |
| NAID | 130007542867 |
| JaLCDOI | 10.18926/CTED/56553 |
|---|---|
| Title Alternative | The Research Trends of Reading Picture-Books to Children in a Whole Group Activity in Early Childhood Education and Care |
| FullText URL | cted_009_215_228.pdf |
| Author | Aizawa, Nohara| Katayama, Mika| Takahashi, Toshiyuki| |
| Abstract | 本研究では，日常の保育で頻繁に行われる，集団での絵本の読み聞かせに関する実践的な研究を概観し，充実した絵本の読み聞かせのあり方に関する知見の整理を試みた。その結果，絵本の読み聞かせ場面における幼児の言動は年齢に沿って変化し，４歳児から５歳児に至る過程において，集団という特徴が活かされるようになることが明らかになった。 ３歳児では，保育者と幼児の個別の関係性が優位であったが，4歳児では徐々に幼児間の相互作用が広がり，他児の発話を繰り返したり，幼児と笑い合ったり等，他児を意識し，一緒に楽しむ共有化が進む。さらに，５歳児になると友達と共に内容の展開を楽しみながら，集団での読み聞かせのマナーを心得た態度を示しつつ，個別の言動の表出を調整する姿が見られるようになることが示された。質の高い読み聞かせにより，幼児の確かな言葉の発達を促す機会に成り得ることが確認された。 |
| Keywords | 幼児 絵本の読み聞かせ 集団 保育者 共有過程 |
| Publication Title | Bulletin of Center for Teacher Education and Development, Okayama University |
| Published Date | 2019-03-20 |
| Volume | volume9 |
| Start Page | 215 |
| End Page | 228 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2019 岡山大学教師教育開発センター |
| File Version | publisher |
| JaLCDOI | 10.18926/AMO/56461 |
|---|---|
| FullText URL | 73_1_71.pdf |
| Author | Takahashi-Arimasa, Keiko| Kohno-Yamanaka, Reiko| Soga, Yoshihiko| Miura, Rumi| Morita, Manabu| |
| Abstract | Preoperative oral care is helpful to prevent postoperative complications in patients who are undergoing esophagectomy. Here, we report the case of an 81-year-old Japanese man with an upper limb disability caused by post-polio syndrome who was receiving neoadjuvant chemotherapy for esophageal cancer. He had poor oral health status and developed oral complications as a side effect of chemotherapy. He could not brush his teeth by himself. However, infection control by oral care provided by an interprofessional collaboration successfully improved his oral hygiene, and his follow-up involved no severe complications. Interprofessional collaboration is useful especially for patients with upper limb disability. |
| Keywords | esophageal cancer preoperative oral care post-polio syndrome neoadjuvant chemotherapy oral mucositis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 71 |
| End Page | 76 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820057 |
| JaLCDOI | 10.18926/AMO/56456 |
|---|---|
| FullText URL | 73_1_29.pdf |
| Author | Matsumoto, Atsushi| Nakamura, Takehiro| Shinomiya, Aya| Kawakita, Kenya| Kawanishi, Masahiko| Miyake, Keisuke| Kuroda, Yasuhiro| Keep, Richard F.| Tamiya, Takashi| |
| Abstract | Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS. |
| Keywords | biomarker histidine-rich glycoprotein predictor subarachnoid hemorrhage vasospasm |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 29 |
| End Page | 39 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820052 |
| JaLCDOI | 10.18926/AMO/56455 |
|---|---|
| FullText URL | 73_1_21.pdf |
| Author | Oiwa, Yuko| Watanabe, Toyohiko| Sadahira, Takuya| Ishii, Ayano| Sako, Tomoko| Inoue, Miyabi| Wada, Koichiro| Kobayashi, Yasuyuki| Araki, Motoo| Nasu, Yasutomo| |
| Abstract | We measured basal clitoral blood flow by Doppler sonography to determine whether tension-free vaginal mesh(TVM) affects the clitoral blood flow and sexual function in women with pelvic organ prolapse (POP). We performed a prospective study of 22 patients who underwent TVM for POP. Clitoral blood flow was measured by Doppler ultrasound. The resistance index (RI), pulsatility index (PI), peak systolic velocity (PSV), and end-diastolic velocity (EDV) of the clitoral arteries were measured preoperatively and at 1, 3, and 6 months postoperatively. Female sexual function was also investigated with the Female Sexual Function Index (FSFI). The mean PI and RI were increased at 1 month and significantly decreased at 6 months postoperatively (p<0.05). In contrast, the mean PSV and EDV decreased at 1 month postoperatively and increased at 6 months postoperatively. These four parameters recovered to baseline levels at 6 months following surgery. Total FSFI scores improved significantly from 10.2±7.9 at baseline to 18.2±8.9 at 6 months postoperatively. Color Doppler ultrasonography is potentially useful in measuring clitoral blood flow in patients treated with TVM for POP. Prospective long-term studies are needed to evaluate the utility of this modality as a diagnostic and prognostic tool for female sexual dysfunction. |
| Keywords | clitoris pelvic organ prolapse Doppler ultrasound |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 21 |
| End Page | 27 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820051 |
| JaLCDOI | 10.18926/AMO/56453 |
|---|---|
| FullText URL | 73_1_7.pdf |
| Author | Fukumori, Norio| Sonohata, Motoki| Kitajima, Masaru| Kawano, Shunsuke| Kurata, Tsuyoshi| Sakanishi, Yuta| Sugioka, Takashi| Mawatari, Masaaki| |
| Abstract | We evaluated the analgesic effects of multimodal pain control in which intravenous acetaminophen (IV APAP) was added to the standard protocol for Japanese patients who had undergone a total hip arthroplasty (THA). We performed a retrospective cohort study of 180 patients aged 66.4±10.5 years (30% male) who had undergone a THA (Oct. 2014 to Feb. 2015) at our hospital. The control patients were administered the standard analgesic protocol: flurbiprofen axetil as a continuous intravenous infusion and oral celecoxib (NAPAP; n=109). The patients in the new analgesic protocol group received IV APAP in addition to the standard analgesic protocol (APAP; n=71). The primary outcome was the maximum value of postoperative pain the patients reported on a numerical rating scale (NRS) during the first 24 h post-surgery. A univariate analysis and multivariate analyses adjusted for age, sex, the stage of hip osteoarthritis, preoperative pain, and surgical time showed that the maximum postoperative pain NRS scores during the first 24 h after surgery was significantly lower when the APAP protocol was used. The addition of IV APAP to the current standard multimodal analgesia protocol for Japanese patients who have undergone a THA may decrease the patients’ postoperative pain. |
| Keywords | intravenous acetaminophen postoperative pain total hip arthroplasty osteoarthritis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 7 |
| End Page | 14 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820049 |
| JaLCDOI | 10.18926/AMO/56452 |
|---|---|
| FullText URL | 73_1_1.pdf |
| Author | Morizane, Shin| |
| Abstract | Excessive protease activity is a characteristic abnormality that affects the epidermal barrier in patients with atopic dermatitis (AD). Kallikrein-related peptidases (KLKs) are excessively expressed in AD lesions, and it is suggested that the abnormal action of KLKs is involved in the skin barrier dysfunction in AD. In other words, overexpressed KLKs disrupt the normal barrier function, and due to that breakdown, external substances that can become antigens of AD easily invade the epidermis, resulting in dermatitis, coupled with the induction of Th2 cytokines. Further investigations are required to elucidate the role of KLKs in AD; this knowledge could contribute to the design of new therapeutic and prophylactic drugs for AD. |
| Keywords | atopic dermatitis kallikrein-related peptidases epidermal barrier dysfunction |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820048 |
| Title Alternative | The 2017 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2017 Sunada Prize) |
|---|---|
| FullText URL | 130_57.pdf |
| Author | Haruma, Jun| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-08-01 |
| Volume | volume130 |
| Issue | issue2 |
| Start Page | 57 |
| End Page | 59 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.57 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.57 |
| NAID | 130007481048 |
| FullText URL | PhysRevA_81_063623.pdf |
|---|---|
| Author | Huhtamaki, J. A. M.| Takahashi, M.| Simula, T. P.| Mizushima, T.| Machida, K.| |
| Note | This is an article published by American Physical Society| |
| Published Date | 2010-06-14 |
| Publication Title | Physical Review A |
| Volume | volume81 |
| Issue | issue6 |
| Publisher | American Physical Society |
| Start Page | 063623 |
| ISSN | 24699926 |
| NCID | AA10764867 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| DOI | 10.1103/PhysRevA.81.063623 |
| Web of Science KeyUT | 000278719500005 |
| Related Url | isVersionOf https://doi.org/10.1103/PhysRevA.81.063623 |
| FullText URL | Support_care_cancer_22_12_3121.pdf |
|---|---|
| Author | Sugiura, Yuko| Soga, Yoshihiko| Tanimoto, Ichiro| Kokeguchi, Susumu| Morishige-Nishide, Sachiko| Itami-Kono, Kotoe| Takahashi, Kanayo| Fujii, Nobuharu| Ishimaru, Fumihiko| Tanimoto, Mitsune| Yamabe, Kokoro| Tsutani, Soichiro| Nishimura, Fusanori| Takashiba, Shogo| |
| Published Date | 2014-12 |
| Publication Title | Supportive Care in Cancer |
| Volume | volume22 |
| Issue | issue12 |
| Publisher | Springer |
| Start Page | 3121 |
| End Page | 3122 |
| ISSN | 0941-4355 |
| NCID | AA10996793 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 25239598 |
| DOI | 10.1007/s00520-014-2432-8 |
| Web of Science KeyUT | 000344644100001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00520-014-2432-8 |
| JaLCDOI | 10.18926/AMO/56186 |
|---|---|
| FullText URL | 72_4_441.pdf |
| Author | Kida, Daihei| Hashimoto, Hiroya| Saito, Akiko M.| Kito, Yukari| Mori, Kouichi| Terabe, Kenya| Takahashi, Nobunori| Tomita, Yasushi| |
| Abstract | There is no assistive device for extramedullary surgery coordinated with 3D surgical assistive software for the total knee arthroplasty (TKA). We developed a novel extramedullary universal guide coordinated with 3D surgical assistive software and a novel extramedullary patient-specific assistive guide for the placement of femoral components by referring to an area not affected by cartilage or bone spurs, and filed a patent application. In this study, we visualize and reconstruct the total alignment of the lower extremity in TKA using these surgical devices, and validate their precision. A report releasing study results will be submitted in an appropriate journal. |
| Keywords | total knee arthroplasty 3D surgical assistive software tibia femur extramedullary guide |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-08 |
| Volume | volume72 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 441 |
| End Page | 445 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30140096 |
| JaLCDOI | 10.18926/AMO/56172 |
|---|---|
| FullText URL | 72_4_369.pdf |
| Author | Iwamoto, Takayuki| Taira, Naruto| Fujisawa, Tomomi| Araki, Kazuhiro| Sakamaki, Kentaro| Sangai, Takafumi| Kikawa, Yuichiro| Shien, Tadahiko| Takao, Shintaro| Sato, Masako| Goto, Yoshinari| Yoshida, Takashi| Takahashi, Masato| Aihara, Tomohiko| Mukai, Hirofumi| |
| Abstract | The Hormonal therapy resistant estrogen-receptor positive metastatic breast cancer cohort (HORSE-BC) study is a multicenter observational study evaluating the efficacy and safety of secondary endocrine therapy (ET) for postmenopausal cases of metastatic breast cancer (MBC) with poor response to primary ET. In this initial report we analyze the HORSE-BC baseline data to clarify the current status of treatment selection for MBC in Japan. Baseline data for the 50 patients enrolled in HORSE-BC were analyzed, including patient characteristics, types of secondary ET, and reasons for selecting secondary ET. Postoperative recurrence was detected in 84% of patients (42/50) and de novo stage IV breast cancer in 16% (8/50). Forty-one patients (41/50; 82%) received fulvestrant, 5 patients (10%) received selective estrogen receptor modulators (SERMs), 3 patients (6%) received ET plus a mammalian target of rapamycin (mTOR) inhibitor, and 1 patient received an aromatase inhibitor (AI) as the secondary ET. Forty-five patients selected their secondary ET based on its therapeutic effect, while 14 patients selected it based on side effects. Most patients with progression after primary ET selected fulvestrant as the secondary ET based on its therapeutic and side effects. We await the final results from the HORSE-BC study. |
| Keywords | breast cancer secondary endocrine therapy low sensitivity primary endocrine therapy fulvestrant |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-08 |
| Volume | volume72 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 369 |
| End Page | 374 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30140084 |
| Title Alternative | Transcription factor Runx3 in the mouse hypothalamo-pituitary-gonadal system |
|---|---|
| FullText URL | poalas_034_002.pdf |
| Author | Takahashi, Sumio| |
| Abstract | Runx3 is a transcription factor that belongs to the Runx family. Female Runx3 knockout (Runx3−⁄−) mouse was anovulatory and infertile. Ovarian transplantation experiment suggested that lack of ovulation in Runx3−⁄− mice was caused by alteration of gonadotropin secretion in Runx3−⁄− mice. Cyp11a1 mRNA expression was less in Runx3−⁄− mouse ovaries than in wt ones. Hypothalamic Gnrh1 mRNA was increased, and Kiss1 mRNA expression in the anteroventral periventricular nucleus was decreased, but Kisspeptin mRNA in the arcuate nucleus was increased in Runx3-/- mice. Pituitary Fshb mRNA levels were increased in Runx3−⁄− mice. Cholesterol side-chain cleavage enzyme gene (Cyp11a1) expression was decreased in ovaries of Runx3−⁄− mice. These findings suggest that anovulation in Runx3−⁄− mice was partly due to the alterations in hypothalamus-pituitary-ovary system. Runx3 plays a key role in female reproduction through alteration of gonadotropin secretion. |
| Publication Title | Proceedings of Okayama Association for Laboratory Animal Science |
| Published Date | 2018-04 |
| Volume | volume34 |
| Start Page | 2 |
| End Page | 4 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/AMO/55861 |
|---|---|
| FullText URL | 72_2_189.pdf |
| Author | Nakao, Shinichiro| Hagiya, Hideharu| Kimura, Keigo| Mitsui, Tomomi| Oyama, Akane| Hongyo, Kazuhiro| Takahashi, Yusuke| Nakagami, Futoshi| Tomono, Kazunori| Rakugi, Hiromi| |
| Abstract | A 65-year-old Japanese man with bilateral carotid atherosclerosis presented with right neck pain and fever. Contrast-enhanced computed tomography suggested carotid arteritis, and carotid ultrasonography showed an unstable plaque. The patient developed a cerebral embolism, causing a transient ischemic attack. Helicobacter cinaedi was detected in blood culture, and H. cinaedi-associated carotid arteritis was diagnosed. Empirical antibiotic therapy was administered for 6 weeks. After readmission for recurrent fever, he was treated another 8 weeks. Although the relationship between H. cinaedi infection and atherosclerosis development remains unclear, the atherosclerotic changes in our patient’s carotid artery might have been attributable to H. cinaedi infection. |
| Keywords | atherosclerosis bacteremia bacterial translocation Helicobacter cinaedi vascular infection |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-04 |
| Volume | volume72 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 189 |
| End Page | 192 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29674769 |
| JaLCDOI | 10.18926/AMO/55854 |
|---|---|
| FullText URL | 72_2_137.pdf |
| Author | Takahashi, Yuko| Shien, Tadahiko| Sakamoto, Ai| Tsuyumu, Yuko| Yoshioka, Ryo| Uno, Maya| Hatono, Minami| Kochi, Mariko| Kawada, Kengo| Tsukioki, Takahiro| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Matsuoka, Junji| Nakatsuka, Mikiya| Doihara, Hiroyoshi| |
| Abstract | Adverse effects on fertility are a significant problem for premenopausal breast cancer patients. Since April 2009, we have been referring young patients for fertility counseling provided by a multidisciplinary team. Here we evaluated the efficacy and safety of our current fertility preservation approach. We retrospectively analyzed the cases of 277 patients < 45 years old at diagnosis, which was made between 2009 and 2016. Seventy-two (26%) patients received fertility counseling. Seventeen (6%) of the 277 patients decided to preserve their fertility before starting adjuvant systemic therapy. Six (35%) patients underwent oocyte cryopreservation, and 11 (65%) married patients opted for embryo cryopreservation. There were no pregnancies among the patients undergoing oocyte cryopreservation, whereas 3 (27%) of the patients who opted for embryo cryopreservation became pregnant. Two (12%) patients stopped endocrine therapy after 2 years in an effort to become pregnant, but their breast cancers recurred. Though the problem of fertility loss for breast cancer patients is important and we should assess the infertility risk for all patients, we should also consider the prognosis. In June 2016, we launched a prospective multicenter cohort study to evaluate the efficacy and safety of fertility preservation in greater detail. |
| Keywords | fertility preservation multidisciplinary breast cancer young patients |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-04 |
| Volume | volume72 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 137 |
| End Page | 142 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29674762 |
| JaLCDOI | 10.18926/CTED/55804 |
|---|---|
| Title Alternative | Development of Junior High School Home Economics Classes Related to Contact With Infants that Encourages Self-acceptance |
| FullText URL | cted_008_015_029.pdf |
| Author | Kando, Etsuko| Katayama, Mika| Takahashi, Toshiyuki| Nishiyama, Osamu| |
| Abstract | 中学生の幼児との触れ合い体験の意義については，先行研究によって示されてきたが，体験の何が効果を及ぼしているのか，実証的な研究は未だ少ない。そこで本論では，「他者から受容される経験が，自己受容を促す」との実践的な仮説を立て，触れ合い体験による他者から受容される経験が，自己受容を促す可能性を検討する。触れ合い体験において，幼児は先入観や条件なしに関わってくることが予想される。そのような幼児に受容される体験は，生徒にとって日常的な人間関係とは異なる，得難い経験となり得る。そこを意図的に強化することで，合理的に意義ある授業を作ることが可能となると考える。また，将来の子育てに繋がる，長期的な効果も期待できる。本論では，こうした仮説に基づき，生徒の自己受容に焦点を当て，これを促す中学校家庭科保育領域の授業を開発し報告した。 |
| Keywords | 幼児 (infants) 中学生 (junior high school students) 触れ合い体験 (interactive experiences) 自己受容 (self-acceptance) 授業開発 (development of home economics classes) |
| Publication Title | Bulletin of Center for Teacher Education and Development, Okayama University |
| Published Date | 2018-03-20 |
| Volume | volume8 |
| Start Page | 15 |
| End Page | 29 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2018 岡山大学教師教育開発センター |
| File Version | publisher |
