result 47501 件
| JaLCDOI | 10.18926/AMO/62231 |
|---|---|
| FullText URL | 75_3_357.pdf |
| Author | Takabatake, Daisuke| Kajiwara, Yukiko| Ohtani, Shoichiro| Suzuki, Yoko| Yamamoto, Mari| Kubo, Shinichiro| Ikeda, Masahiko| Takahashi, Mina| Hara, Fumikata| Aogi, Kenjiro| Ohsumi, Shozo| Ogasawara, Yutaka| Nishiyama, Yoshitaka| Hikino, Hajime| Matsuoka, Kinya| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| |
| Abstract | Perioperative dose-dense chemotherapy (DDCT) with pegfilgrastim (Peg) prophylaxis is a standard treatment for high-risk breast cancer. We explored the optimal timing of administration of 3.6 mg Peg, the dose approved in Japan. In the phase II feasibility study of DDCT (adriamycin+cyclophosphamide or epirubicin+cyclophosphamide followed by paclitaxel) for breast cancer, we investigated the feasibility, safety, neutrophil transition, and optimal timing of Peg treatment by administering Peg at days 2, 3, and 4 post-chemotherapy (P2, P3, and P4 groups, respectively). Among the 52 women enrolled, 13 were aged > 60 years. The anthracycline sequence was administered to P2 (n=33), P3 (n=5), and P4 (n=14) patients, and the taxane sequence to P2 (n=38) and P3 (n=6) patients. Both sequences showed no interaction between Peg administration timing and treatment discontinuation, treatment delay, or dose reduction. However, the relative dose intensity (RDI) was significantly different among the groups. The neutrophil count transition differed significantly among the groups receiving the anthracycline sequence. However, the neutrophil count remained in the appropriate range for both sequences in the P2 group. The timing of Peg administration did not substantially affect the feasibility or safety of DDCT. Postoperative day 2 might be the optimal timing for DDCT. |
| Keywords | dose-dense chemotherapy breast cancer pegfilgrastim |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 357 |
| End Page | 362 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176940 |
| Web of Science KeyUT | 000667147700011 |
| NAID | 120007089828 |
| JaLCDOI | 10.18926/AMO/62230 |
|---|---|
| FullText URL | 75_3_351.pdf |
| Author | Mitamura, Katsuya| Norikane, Takashi| Yamamoto, Yuka| Ihara-Nishishita, Ayumi| Kobata, Takuya| Fujimoto, Kengo| Takami, Yasukage| Kudomi, Nobuyuki| Hoshikawa, Hiroshi| Nishiyama, Yoshihiro| |
| Abstract | We assessed the role of 18F-FDG PET/CT texture indices for the differentiation of squamous cell carcinoma (SCC) and non-Hodgkin’s lymphoma (NHL) in the oropharynx. 18F-FDG PET/CT data for 27 patients with SCC and 25 patients with NHL in the oropharynx were investigated. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and six texture indices (homogeneity, entropy, short-run emphasis, long-run emphasis, low gray-level zone emphasis [LGZE], and high graylevel zone emphasis [HGZE]) were derived from PET images. PET/CT parameters of the SCC patients were compared with those of the NHL patients. The diagnostic accuracy of the indices for differentiating SCC from NHL was calculated by a receiver operating characteristic curve analysis. 18F-FDG uptake in the oropharynx was observed in all of the patients. The SUVmax, MTV, and TLG did not differ significantly between the SCC and NHL groups, but two of the six texture indices (LGZE [p=0.004] and HGZE [p=0.03]) showed significant differences between the groups. LGZE was the best discriminative index for the differentiation of SCC and NHL (55.6% sensitivity, 88.0% specificity). The LGZE and HGZE texture indices derived from 18F-FDG PET/CT images may be useful in differentiating SCC and NHL in the oropharynx. |
| Keywords | 18F-FDG PET/CT oropharyngeal squamous cell carcinoma malignant lymphoma texture |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 351 |
| End Page | 356 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176939 |
| Web of Science KeyUT | 000667147700010 |
| NAID | 120007089827 |
| JaLCDOI | 10.18926/AMO/62229 |
|---|---|
| FullText URL | 75_3_345.pdf |
| Author | Koyama, Kanae| Miura, Noriyoshi| Watanabe, Ryuta| Sawada, Yuichiro| Noda, Terutaka| Nishimura, Kenichi| Asai, Seiji| Fukumoto, Tetsuya| Yanagihara, Yutaka| Miyauchi, Yuki| Kikugawa, Tadahiko| Saika, Takashi| |
| Abstract | The management of blood pressure is a significant concern for surgeons and anesthesiologists performing adrenalectomy for pheochromocytoma. We evaluated clinical factors in pheochromocytoma patients to identify the predictors of postoperative hypotension. The medical records of patients who underwent adrenalectomy for pheochromocytoma between 2001 and 2017 were retrospectively reviewed and clinical and biochemical data were evaluated. Of 29 patients, 13 patients needed catecholamine support in the perisurgical period while 16 patients did not. There were significant differences in median age, tumor size, and blood pressure drop (maxmin) between the 2 groups (68 vs 53 years old, p=0.045; 50 vs 32 mm diameter, p=0.022; 110 vs 71 mmHg, p=0.015 respectively). In univariate logistic analysis, age > 65.5 years, tumor size > 34.5 mm, urine metanephrine > 0.205 mg/day and urine normetanephrine > 0.665 mg/day were significant predictors of prolonged hypotension requiring postoperative catecholamine support. Tumor size and urine metanephrine and urine normetanephrine levels were correlated with postoperative hypotension. These predictors may help in the safe perioperative management of pheochromocytoma patients treated with adrenalectomy. |
| Keywords | urinary metanephrine urinary normetanephrine adrenalectomy pheochromocytoma |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 345 |
| End Page | 349 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176938 |
| Web of Science KeyUT | 000667147700009 |
| NAID | 120007089826 |
| JaLCDOI | 10.18926/AMO/62228 |
|---|---|
| FullText URL | 75_3_335.pdf |
| Author | Chikuie, Nobuyuki| Hamamoto, Takao| Ueda, Tsutomu| Taruya, Takayuki| Kono, Takashi| Furuie, Hiromi| Ishino, Takashi| Takeno, Sachio| |
| Abstract | Recurrent or metastatic head and neck squamous cell carcinoma (R/MHNSCC) has a poor prognosis. Although nivolumab is approved in Japan for treating R/MHNSCC, the response rate is low. Therefore, identifying pretreatment prognostic factors is necessary. This study assessed the utility of the neutrophil-to-lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS) as biomarkers of response to nivolumab. We retrospectively collected the data of 56 R/MHNSCC patients treated with nivolumab between May 2017 and December 2019. The Kaplan–Meier method and log-rank test were used to estimate overall survival (OS) and progression-free survival (PFS), and multivariate Cox hazard regression analysis was used to identify independent predictors of survival. Patients with a low pretreatment NLR had prolonged OS, and patients with a low pretreatment GPS had increased OS and PFS. A performance score (PS) of 0-1, development of immune-related adverse events, and GPS of 0-1 were significantly associated with OS in multivariate analysis. In summary, baseline pretreatment NLR and GPS are independently associated with OS in R/MHNSCC patients treated with nivolumab. Administration of nivolumab while maintaining the PS reflects a immune status of the host and leads to a good OS. |
| Keywords | neutrophil-to-lymphocyte ratio nivolumab Glasgow Prognostic Score recurrent or metastatic head and neck squamous cell carcinoma (R/MHNSCC) |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 335 |
| End Page | 343 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176937 |
| Web of Science KeyUT | 000667147700008 |
| NAID | 120007089825 |
| JaLCDOI | 10.18926/AMO/62227 |
|---|---|
| FullText URL | 75_3_323.pdf |
| Author | Furutani, Michiyo| Yu, Zhou| Nakatsuka, Mikiya| |
| Abstract | Gender expression is important for transgender women to improve their social passing as women. Herein, a questionnaire about the status of gender expression and support needs was distributed to 54 transgender women aged 17-71 in Japan. Most of the respondents noted that they had found it relatively difficult to handle physical changes and weight gain due to hormone treatment. They also found it difficult to enact and sustain practices such as a feminine use of voice and to use women-only services, whereas practicing and continuing with routine skin and hair care and feminine mannerisms were relatively easy for them. In the questionnaire regarding the support for gender transitioning, many items showed only a small percentage of the transgender women had received the support that they were looking for, and most of their needs for support were not addressed. Some of the factors that increased the respondents’ needs and achievement of gender expression as women included estrogen treatment, sex reassignment surgery, and living as a woman; these aspects met their support needs as well. Gender support professionals need to coordinate and collaborate with specialists in areas such as nutritional guidance and voice training to enable transgender women to improve the extent to which they can socially ‘pass’ as women. |
| Keywords | transgender gender expression social passing as a woman real life experience gender transition |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 323 |
| End Page | 334 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176936 |
| Web of Science KeyUT | 000667147700007 |
| NAID | 120007089824 |
| JaLCDOI | 10.18926/AMO/62226 |
|---|---|
| FullText URL | 75_3_315.pdf |
| Author | Wada, Riho| Fujiwara, Masaki| Yamada, Yuto| Nakaya, Naoki| Fujimori, Maiko| So, Ryuhei| Kodama, Masafumi| Higuchi, Yuji| Kakeda, Kyoko| Uchitomi, Yosuke| Yamada, Norihito| Inagaki, Masatoshi| |
| Abstract | It is necessary to assess functional impairment when treating schizophrenia. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) has been adopted as a measure of functional disability in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. This study was a secondary analysis from a cross-sectional study of health-related behaviors among patients with schizophrenia. We examined the validity and reliability of the Japanese version of the 12-item WHODAS 2.0 when self-administered by such patients. Participants were 350 outpatients with schizophrenia from a psychiatric hospital. The standard six-factor structure of the WHODAS 2.0 showed a good fit for these participants. The Cronbach’s alpha coefficient was 0.858, showing good internal consistency. The WHODAS 2.0 showed moderate correlations with the modified Global Assessment of Functioning and Kessler 6 scales (r=−0.434 and 0.555, respectively). The results of this study show that the Japanese version of the 12-item self-administered WHODAS 2.0 has good internal consistency and convergent validity among patients with schizophrenia. Further exploration of the usefulness of WHODAS 2.0 in clinical settings is needed. |
| Keywords | disability schizophrenia validity reliability WHODAS 2.0 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 315 |
| End Page | 322 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176935 |
| NAID | 120007089823 |
| JaLCDOI | 10.18926/AMO/62225 |
|---|---|
| FullText URL | 75_3_307.pdf |
| Author | Ishizaka, Hinata| Kuroda, Masahiro| Tekiki, Nouha| Khasawneh, Abdullah| Barham, Majd| Hamada, Kentaro| Konishi, Kohei| Sugimoto, Kohei| Katsui, Kuniaki| Sugiyama, Soichi| Watanabe, Kenta| Yoshio, Kotaro | Katayama, Norihisa| Ogata, Takeshi| Ihara, Hiroki| Oita, Masataka| Kanazawa, Susumu| Asaumi, Junichi| |
| Abstract | Reports on irradiation dose distribution in breast cancer radiotherapy with sufficient sample size are limited in Asian patients. Elucidating dose distribution in Asian patients is particularly important as their breast volume differs compared to patients in Europe and North America. Here, we examined dose distribution in the irradiation field relative to breast volume for three irradiation methods historically used in our facility. We investigated the influence of breast volume on each irradiation method for Asian women. A total of 573 women with early-stage breast cancer were treated with breast-conserving surgery and adjuvant radiotherapy. Three methods were compared: wedge (W), field-in-field (FIF), and wedge-field-in-field (W-FIF). In patients with small breast volume, FIF decreased low- and high-dose areas within the planning target volume, and increased optimal dose area more than W. In patients with medium and large breast volumes, FIF decreased high-dose area more than W. The absolute values of correlation coefficients of breast volume to low-, optimal-, and high-dose areas and mean dose were significantly lower in FIF than in W. The correlation coefficients of V107% were 0.00 and 0.28 for FIF and W, respectively. FIF is an excellent irradiation method that is less affected by breast volume than W in Asian breast cancer patients. |
| Keywords | breast cancer radiotherapy dose distribution irradiation method breast volume |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 307 |
| End Page | 314 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176934 |
| Web of Science KeyUT | 000667147700006 |
| NAID | 120007089838 |
| FullText URL | fulltext20210623-2.pdf figure20210623-2.pdf |
|---|---|
| Author | Otsuka, Yuki| Hagiya, Hideharu| Nakano, Yasuhiro| Omura, Daisuke| Hasegawa, Kou| Yamada, Haruto| Iio, Koji| Honda, Tomoyuki| Otsuka, Fumio| |
| Keywords | Human coronavirus Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 |
| Note | © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jiac.2021.05.001| |
| Published Date | 2021-7 |
| Publication Title | Journal of Infection and Chemotherapy |
| Volume | volume27 |
| Issue | issue7 |
| Publisher | Elsevier BV |
| Start Page | 1126 |
| End Page | 1128 |
| ISSN | 1341-321X |
| NCID | AA11057978 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. |
| File Version | author |
| PubMed ID | 33994323 |
| DOI | 10.1016/j.jiac.2021.05.001 |
| Web of Science KeyUT | 000656910200036 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jiac.2021.05.001 |
| FullText URL | fulltext20210623-1.pdf |
|---|---|
| Author | Matsuo, Toshihiko| Liu, Shihui| Uchida, Tetsuya| Onoue, Satomi| Nakagawa, Shinsaku| Ishii, Mayumi| Kanamitsu, Kayoko| |
| Keywords | NK-5962 photoelectric dye apoptosis retinal neuron neuroprotection pharmacokinetics ADME phototoxic/photosensitive assay reactive oxygen species assay photosafety |
| Published Date | 2021-6-21 |
| Publication Title | Life |
| Volume | volume11 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 591 |
| ISSN | 2075-1729 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors |
| File Version | publisher |
| NAID | 120007089837 |
| DOI | 10.3390/life11060591 |
| Related Url | isVersionOf https://doi.org/10.3390/life11060591 |
| JaLCDOI | 10.18926/AMO/62221 |
|---|---|
| FullText URL | 75_3_299.pdf |
| Author | Araki, Jo| Oka, Kosuke| Yamamoto, Koichiro| Hanayama, Yoshihisa | Tokumasu, Kazuki| Hagiya, Hideharu| Ogawa, Hiroko| Itoshima, Koichi| Otsuka, Fumio| |
| Abstract | Various laboratory markers of inflammation are utilized in general practice, but their clinical diagnostic significance is often ambiguous. In the present study, we determined the clinical significance of the examination of serum levels of procalcitonin (PCT) by comparing the PCT levels with the levels of other inflammatory markers, based on a retrospective review of 332 PCT-positive patients, including cases of bacterial infection (20.5%), non-specific inflammation (20.8%), neoplasm (9.9%), connective tissue diseases (8.4%), and non-bacterial infection (7.2%), were analyzed. The serum PCT level was highest in the bacterial infection group (1.94 ng/ml) followed by the non-specific inflammatory group (0.58 ng/ml) and neoplastic diseases group (0.34 ng/ml). The serum PCT level was positively correlated with serum levels of C-reactive protein (rho=0.62), soluble interleukin-2 receptor (sIL-2R; rho=0.69), and ferritin, the plasma level of D-dimer, and white blood cell count, and negatively correlated with the serum albumin level (rho=−0.52), hemoglobin concentration, and platelet count. The serum PCT level showed a stronger positive correlation with the serum sIL-2R level than the other biomarkers. The results suggest that an increased PCT level may indicate not only an infectious state but also a non-bacterial inflammatory condition in the diagnostic process in general practice. |
| Keywords | bacterial infection inflammation malignant lymphoma procalcitonin soluble interleukin-2 receptor |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 299 |
| End Page | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176933 |
| Web of Science KeyUT | 000667147700005 |
| NAID | 120007089836 |
| JaLCDOI | 10.18926/AMO/62220 |
|---|---|
| FullText URL | 75_3_289.pdf |
| Author | Miyamoto, Masakazu| Osawa, Kazuhiro| Miyoshi, Toru| Mori, Atsushi| Yoshikawa, Masaki| Oka, Takefumi| Ichikawa, Keishi| Nakamura, Kazufumi| Ito, Hiroshi| |
| Abstract | Early treatment with an oral β-blocker is recommended in patients with a ST-segment–elevation myocardial infarction (STEMI). In this multicenter study, we evaluated the effects of a continuous administration of landiolol, an ultrashort-acting β-blocker, before primary percutaneous coronary intervention (PCI) on myocardial salvage and its safety in STEMI patients. A total of 47 Japanese patients with anterior or lateral STEMI undergoing a primary PCI within 12 h of symptom onset were randomized to receive intravenous landiolol (started at 3 μg/min/kg dose and continued to a total of 50 mg; n=23) or not (control; n=24). Patients with Killip class III or more were excluded. The primary outcome was the myocardial salvage index on cardiac magnetic resonance imaging (MRI) performed 5-7 days after the PCI. Cardiac MRI was performed in 35 patients (74%). The myocardial salvage index in the landiolol group was significantly greater than that in the control group (44.4±14.6% vs. 31.7±18.9%, respectively; p=0.04). There were no significant differences in adverse events at 24 h between the landiolol and control groups. A continuous administration of landiolol before a primary PCI may increase the degree of myocardial salvage without additional hemodynamic adverse effects within the first 24 h after STEMI. |
| Keywords | myocardial infarction landiolol magnetic resonance imaging STEMI PCI |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 289 |
| End Page | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176932 |
| Web of Science KeyUT | 000667147700004 |
| NAID | 120007089835 |
| JaLCDOI | 10.18926/AMO/62219 |
|---|---|
| FullText URL | 75_3_279.pdf |
| Author | Nishinohara, Masa-aki| Nishimori, Hisakazu| Fujiwara, Hideaki| Asada, Noboru| Ennishi, Daisuke| Matsuoka, Ken-ichi| Fujii, Keiko| Fujii, Nobuharu| Maeda, Yoshinobu| |
| Abstract | A bloodstream infection (BSI) is the most common serious infectious complication of hematopoietic stem cell transplantation (HSCT). BSI promotes an inflammatory state, which exacerbates acute graft-versus-host disease (GVHD). We investigated whether a Gram-negative rod bloodstream infection (GNR-BSI), which develops early after allo-HSCT, affected the onset or exacerbated acute GVHD in 465 patients who underwent allo-HSCT from 1995 through 2015 at a single institution. Eighty-eight patients (19%) developed BSI during the study period. Among the cultures, 50 (57%) were Gram-positive cocci (GPC) and 31 (35%) were GNR. Of the 465 patients, 187 (40%) developed acute GVHD of grade II or higher within the first 100 days post-allogeneic HSCT: 124 (27%) had acute GVHD grade II, 47 (10%) had grade III, and 16 (3%) had grade IV. Multivariate analysis revealed that GNR-BSI was a significant risk factor for grade II-IV acute GVHD (grade II-IV: hazard ratio [HR] 1.75, 95% confidence interval [CI] 1.03-2.97; grade III-IV: HR 2.37, 95% CI 1.03-5.43). These results suggest that GNR-BSI may predict the onset and exacerbation of acute GVHD. |
| Keywords | blood stream infection graft-versus-host disease gram negative rods |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 279 |
| End Page | 287 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176931 |
| Web of Science KeyUT | 000667147700003 |
| NAID | 120007089834 |
| JaLCDOI | 10.18926/AMO/62218 |
|---|---|
| FullText URL | 75_3_269.pdf |
| Author | Katsui, Kuniaki| Ogata, Takeshi| Watanabe, Kenta| Yoshio, Kotaro| Kuroda, Masahiro| Hiraki, Takao| Kiura, Katsuyuki| Maeda, Yoshinobu| Toyooka, Shinichi| Kanazawa, Susumu| |
| Abstract | Palliative concurrent chemoradiotherapy (CCRT) is often administered to patients with stage III non-small cell lung cancer (NSCLC). We investigated the clinical outcomes of patients receiving palliative CCRT for NSCLC. Data of patients with NSCLC who underwent palliative CCRT (n=16), preoperative CCRT plus surgery (n=97), or definitive CCRT (n=48) were evaluated. In all groups, the concurrent chemotherapy regimens consisted of cisplatin and docetaxel. Rates of local control (LC), distant metastasis-free survival (DMFS), progression-free survival (PFS), overall survival (OS), and prognosis were compared. The 2-year rates of LC, DMFS, PFS, and OS in 16 patients who underwent palliative CCRT were 44.4%, 12.5%, 12.5%, and 18.8%, respectively. Univariate analysis showed that palliative CCRT was associated with poor LC (p<0.001), DMFS (p<0.001), PFS (p<0.001), and OS (p<0.001) outcomes in patients who completed CCRT as a preoperative treatment and poor LC (p=0.01), DMFS (p=0.003), PFS (p=0.04), and OS (p=0.004) outcomes in patients who were considered for definitive CCRT. Although there were some long-term survivors, the clinical outcomes of palliative CCRT were significantly inferior to those of the ideal treatments. Therefore, careful determination of the appropriate treatment indications and further studies are warranted. |
| Keywords | palliative concurrent chemoradiotherapy cisplatin/docetaxel stage III non-small cell lung cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 269 |
| End Page | 277 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176930 |
| Web of Science KeyUT | 000667147700002 |
| NAID | 120007089833 |
| JaLCDOI | 10.18926/AMO/62217 |
|---|---|
| FullText URL | 75_3_261.pdf |
| Author | Arapovic, Lidija Lasic| Karlovic, Zoran| Brzovic, Valentina Rajic| Bukvic, Amer| Coric, Anka| Vukojevic, Katarina| Verzak, Zeljko| |
| Abstract | We conducted a retrospective analysis of records of special needs patients (SNPs) who received dental treatment under orotracheal-intubation general anaesthesia (OIGA) at Caritas Centre St. Family in Mostar, Bosnia and Herzegovina during the 14-year period from January 2005 to December 2018. Of the 7,085 SNPs who received dental treatment, 1,220 (17.2%) received dental treatment under OIGA: 829 (67.9%) males and 391 (32.1%) females. The patients’ mean age was 18.3±10.9 years (747 paediatric and 473 adult patients). Mental retardation and psychiatric problems were the most common medical conditions (81.22%). The most common indication for dental treatment under OIGA was behaviour management (87.21%), and 81% of the patients had an urgent need for treatment. Many of the patients had restorative treatment (3,833) and tooth extractions (3,681). From 2011 onwards, the number of tooth extractions decreased significantly. Annual trends revealed a rapid increase of patients every year. The mean dental treatment duration was 95.3±12.1 min; the mean time under OIGA was 98±8.5 min. No serious adverse effects occurred. There was increase of annual trend of SNP in OIGA. The number of extractions decreased while the number of preventive and restorative dental treatments increased. |
| Keywords | special needs patients general anaesthesia dental treatment dental care mental retardation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-06 |
| Volume | volume75 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 261 |
| End Page | 268 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34176929 |
| Web of Science KeyUT | 000667147700001 |
| NAID | 120007089832 |
| FullText URL | fulltext20210622-1.pdf |
|---|---|
| Author | Hui, Kent Ngan-Cheung| Gong , Yuanyuan| Cui, Qi| Jiang, Naipeng| |
| Keywords | Problemistic search Vicarious learning Japan Turnaround Foreign investment and divestment |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Asia Pacific Journal of Management. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10490-021-09778-6| |
| Published Date | 2021-6-9 |
| Publication Title | Asia Pacific Journal of Management |
| Volume | volume39 |
| Issue | issue4 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1481 |
| End Page | 1509 |
| ISSN | 0217-4561 |
| NCID | AA10429308 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | (c) The author(s) |
| File Version | author |
| DOI | 10.1007/s10490-021-09778-6 |
| Web of Science KeyUT | 000659411800001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10490-021-09778-6 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Adachi, Takuya| Takeuchi, Yasuto| Takaki, Akinobu| Oyama, Atsushi| Wada, Nozomu| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki| |
| Keywords | tolvaptan liver cirrhosis ascites |
| Published Date | 2021-05-25 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume22 |
| Issue | issue11 |
| Publisher | MDPI |
| Start Page | 5582 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 34070416 |
| NAID | 120007089839 |
| DOI | 10.3390/ijms22115582 |
| Web of Science KeyUT | 000660134900001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms22115582 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | He, Fang| Matsumoto, Yoshinori| Asano, Yosuke| Yamamura, Yuriko| Katsuyama, Takayuki| La Rose, Jose| Tomonobu, Nahoko| Komalasari, Ni Luh Gede Yoni| Sakaguchi, Masakiyo| Rottapel, Robert| Wada, Jun| |
| Keywords | ABL Abelson murine leukemia viral oncogene homolog Runx2 (runt-related transcription factor 2) tyrosine phosphorylation invasion |
| Note | Erratum in https://ousar.lib.okayama-u.ac.jp/62331| |
| Published Date | 2021-05-31 |
| Publication Title | Frontiers In Oncology |
| Volume | volume11 |
| Publisher | Frontiers Media S.A. |
| Start Page | 665273 |
| ISSN | 2234-943X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 He, Matsumoto, Asano, Yamamura, Katsuyama, La Rose, Tomonobu, Komalasari, Sakaguchi, Rottapel and Wada. |
| File Version | publisher |
| PubMed ID | 34136397 |
| NAID | 120007089841 |
| DOI | 10.3389/fonc.2021.665273 |
| Web of Science KeyUT | 000661158800001 |
| Related Url | isVersionOf https://doi.org/10.3389/fonc.2021.665273 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Tanaka, Takehiro| Sugihara, Yuusaku| Harada, Keita| Hiraoka, Sakiko| Kondo, Yoshitaka| Okada, Hiroyuki| |
| Keywords | endometriosis subepithelial lesion submucosal tumor cecum colonoscopy |
| Published Date | 2021 |
| Publication Title | Internal Medicine |
| Volume | volume60 |
| Issue | issue11 |
| Publisher | Japanese Society of Internal Medicine |
| Start Page | 1697 |
| End Page | 1701 |
| ISSN | 0918-2918 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Japanese Society of Internal Medicine |
| File Version | publisher |
| PubMed ID | 33390498 |
| DOI | 10.2169/internalmedicine.6418-20 |
| Web of Science KeyUT | 000659353300007 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.6418-20 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kuroda, Kosuke| Ishii, Kenzo| Mihara, Yuko| Kawanoue, Naoya| Wake, Hidenori| Mori, Shuji| Yoshida, Michihiro| Nishibori, Masahiro| Morimatsu, Hiroshi| |
| Published Date | 2021-05-13 |
| Publication Title | Scientific Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 10223 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 33986340 |
| NAID | 120007053368 |
| DOI | 10.1038/s41598-021-89555-z |
| Web of Science KeyUT | 000656946100013 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-021-89555-z |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Masuda, Takahiko| Ang, Daniel G.| Hutzler, Nicholas R.| Meisenhelder, Cole| Sasao, Noboru| Uetake, Satoshi| Wu, Xing| DeMille, David| Gabrielse, Gerald| Doyle, John M.| Yoshimura, Koji| |
| Published Date | 2021-05-24 |
| Publication Title | Optics Express |
| Volume | volume29 |
| Issue | issue11 |
| Publisher | Optical Soc Amer |
| Start Page | 16914 |
| End Page | 16926 |
| ISSN | 1094-4087 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement |
| File Version | publisher |
| NAID | 120007053367 |
| DOI | 10.1364/OE.424460 |
| Web of Science KeyUT | 000654369300081 |
| Related Url | isVersionOf https://doi.org/10.1364/OE.424460 |
