| ID | 68459 |
| Author |
Eguchi, Takanori
Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Calderwood, Stuart K.
Division of Molecular and Cellular Biology, Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
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| Abstract | Myeloid zinc finger 1 (MZF1) is a multifaceted transcription factor that can act either as a transcriptional activator or a gene repressor. We examined its production of nuclear bodies (NBs) and subcellular localization. Proteomic and protein–protein interaction analysis were used to identify its cofactors and interactions. These revealed the presence of MZF1-NBs (intranuclear oligomers containing MZF1). MZF-NBs are similar to some other nuclear bodies, notably promyelocytic leukemia (PML) -NBs in terms of size and morphology. However the two structures appear to be different. MZF-NBs and PML-NBs were found to associate in the nucleus. Both MZF1 and PML are SUMO1-SUMOylated in PC-3 cells. Sumoylated MZF1 can interact with proteins containing SUMO-interaction motifs (SIM) through SUMO-SIM interaction. Interactome analysis revealed that its NBs participate in the stress response (TPR and UBAP2L), protein folding (CALR and ANKRD40), transcription, post-translational modification (TRIM33, ACOT7, CAMK2D, and CAMK2G), and RNA binding (ALURBP and CPSF5).
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| Keywords | Myeloid zinc finger 1
MZF1
Nuclear body
PML
Sumoylation
SCAN domain protein
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| Note | © 2025 Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
This fulltext file will be available in Feb. 2026.
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| Published Date | 2025-03-08
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| Publication Title |
Biochemical and Biophysical Research Communications
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| Volume | volume752
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| Publisher | Elsevier BV
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| Start Page | 151481
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| ISSN | 0006-291X
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| NCID | AA00564395
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| Copyright Holders | © 2025 Published by Elsevier Inc.
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| File Version | author
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| PubMed ID | |
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| Related Url | isVersionOf https://doi.org/10.1016/j.bbrc.2025.151481
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| License | https://creativecommons.org/licenses/by-nc-nd/4.0/
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| Funder Name |
Japan Society for the Promotion of Science
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| 助成番号 | 23K28000
22F22409
23K2148606
24K1323906
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