result 5815 件
| Author | Kimura, Keigo| |
|---|---|
| Published Date | 2008-12-31 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Kawasaki, Kensuke| |
|---|---|
| Published Date | 2008-12-31 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Sakamoto, Michiko| |
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| Published Date | 2008-12-31 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Takahashi, Kazuya| |
|---|---|
| Published Date | 2008-12-31 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Kobayashi, Tomoko| |
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| Published Date | 2008-12-31 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Masaka, Takuro| |
|---|---|
| Published Date | 2008-12-31 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Ueda, Naoki| |
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| Published Date | 2008-12-31 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Fujikawa, Tatsuya| Shiraha, Hidenori| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2009-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume121 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/14835 |
|---|---|
| Title Alternative | 気管支喘息における気管支肺胞洗浄液中の細胞成分に対する加齢および副腎皮質ホルモンの影響 |
| FullText URL | 72_016_022.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| |
| Abstract | Effects of aging and glucocorticoid therapy on bronchoalveolar lavage (BAL) cells, particularly lymphocytes, neutrophils and eosinophils, were examined in 81 patients with asthma. 1. The proportion of BAL lymphocytes tended to increase with aging in asthmatics under age 69 years, and the proportion was significantly higher in patients with asthma between the ages of 60 and 69 than in those under age 39 and between the ages of 40 and 49. 2. The proportions of BAL neutrophils and eosinophils were not related to aging. 3. The proportion of BAL lymphocytes was higher in patients without glucocorticoid therapy than in those with steroid-dependent intractable asthma (SOIA) in those under age 69 years. In patients between the ages of 50 and 59, the proportion of BAL lymphocytes was significantly higher in patients without glucocorticoids than in those with SOIA. 4. The proportion of BAL neutrophils was higher in patients without glucocorticoid therapy than in those with SOIA, and the difference was significant in patients between the ages of 60 and 69. 5. The proportion of BAL eosinophils was not related to glucocorticoid therapy. These results suggest that the proportion of BAL lymphocytes and neutrophils is affected by aging and glucocorticoid therapy, but not BAL eosinophils. |
| Keywords | aging asthma glucocorticoid therapy BAL cells |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 16 |
| End Page | 22 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308605 |
| Author | Sakamoto Yasuaki| Ichimura Takumi| Hara Akira| Takahama Tetsuyuki| |
|---|---|
| Published Date | 2008-12-11 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| JaLCDOI | 10.18926/14771 |
|---|---|
| Title Alternative | 食道痛細胞におけるWntのベータカテ二ンTCF経路の活性化の検討 |
| FullText URL | 73_075_080.pdf |
| Author | Mizushima, Takaaki| Ochi, Koji| Emori, Yasuyuki| Tanioka, Hiroaki| Sawa, Kiminari| Fujioka, Shinichi| Shinji, Toshiyuki| Koide, Norio| Tanizaki, Yoshiro| |
| Abstract | Although, accumulation of nuclear and cytoplasmic beta-catenin has been observed in ESCCs, mutation of APC and beta-catenin are not found in ESCCs. Therefore, another mechanism for cytoplasmic beta- catenin accumulation might exist in ESCCs. Materials and Methods: Human ESCCs cell lines and the 293 stable transfectants expressing Wnt-1, Wnt-5A, and Wnt-7A were cultured under standard conditions. The TOPFlash or FOPFlash reporter plasmids were transfected. Results: Transfected mutant beta-catenin as well as an axin fragment harbing the GSK3 beta interaction domain, the latter a potent GSK3 beta inhibitor. both robustly activated pTOPFlash in ESCCs cells. When pTOPFlash/pFOPFlash reporters were transfected in ESCCs cell lines followed by cocultivation with 293 cells that stably express Wnt -1, all cell lines except one demonstrated TCF mediated transcriptional. But, cells were co- cultured, Wnt - 7A or Wnt - 5A did not activate TCF mediated transcription in a cell number dependent fashion. Discussion; We report the activation of TCF promoter gene by extemal Wnt stimuli in ESCCs cells. |
| Keywords | esophageal carcinoma Wnt TCF beta-catenin |
| Publication Title | 岡大三朝医療センター研究報告 |
| Published Date | 2003-02-01 |
| Volume | volume73 |
| Start Page | 75 |
| End Page | 80 |
| ISSN | 1348-1258 |
| language | English |
| File Version | publisher |
| NAID | 120002308224 |
| Author | Yamashita, Hidetoshi| |
|---|---|
| Published Date | 1991 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume103 |
| Issue | issue11-12 |
| Content Type | Journal Article |
| Author | Yamashita, Hidetoshi| |
|---|---|
| Published Date | 1991 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume103 |
| Issue | issue11-12 |
| Content Type | Journal Article |
| Author | Fujiwara, Noriaki| |
|---|---|
| Published Date | 1990-04 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume102 |
| Issue | issue3-4 |
| Content Type | Journal Article |
| Author | Hiraki, Kiyoshi| Ota, Zensuke| Suzuki, Shinya| Takahashi, Kenji| Muguruma, Masahito| |
|---|---|
| Published Date | 1966-01-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume78 |
| Issue | issue1.suppl |
| Content Type | Journal Article |
| Author | Okino, Takeshi| |
|---|---|
| Published Date | 1990-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume102 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| Author | Hirakawa, Eiichiro| |
|---|---|
| Published Date | 1990-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume102 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| Author | Kusaura, Tsutomu| |
|---|---|
| Published Date | 1966-09-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume78 |
| Issue | issue7-9 |
| Content Type | Journal Article |
| Author | Nakatsuka, Ayako| |
|---|---|
| Published Date | 1966-09-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume78 |
| Issue | issue7-9 |
| Content Type | Journal Article |
| Author | Takemoto, Shigeru| |
|---|---|
| Published Date | 1966-09-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume78 |
| Issue | issue7-9 |
| Content Type | Journal Article |
