result 5238 件
| JaLCDOI | 10.18926/15316 |
|---|---|
| Title Alternative | 老年者の気管支喘息. アレルギー反応と気道細胞反応 |
| FullText URL | 063_039_043.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Ochi, Koji| Harada, Hideo| Kimura, Ikuro| |
| Abstract | Clinical features of bronchial asthma in the elderly were analyzed by observlng IgE-mediated allerglc reactions evaluated by immediate skin reaction and specific IgE antibodies to allergens, ventilatory function and cellular composition in bronchoalveolar lavage (BAL) fluid. 1. The frequency of positive immediate skin reaction and positive RAST score to allergens was in general low in the elderly patients over age 70. 2. Ventilatory function was widely variegated, and fifteen cases (60%) of the 25 Subjects showed considerably high values of FEV(l.0%), % PEFR, % MMF, % V(50) and % V(25), and the mean value of FEV(1.0%) in these cases was 71.3%. 3. The decreased value of % V(25) was related to BAL neutrophilia in 2 cases, but any correlation was not found between BAL neutrophilia and decreased value of % V(25) in 9 csese of the eleven subjects who had the BAL examination. The results show that in asthma of elderly patients, IgE-mediated allergic reactions are weak, and that a decreased value of % V(25) can be observed without BAL neutrophilia. |
| Keywords | elderly subjects (老年者) lgE-mediated allergic reaction (IgE系反応) ventilatory function (換気機能) BAL neutrophilia (BAL好中球) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 39 |
| End Page | 43 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307727 |
| JaLCDOI | 10.18926/15315 |
|---|---|
| Title Alternative | Effects of the spring water on the dissolution of aminophylline tablet and theophylline sustained-release preparations |
| FullText URL | 064_060_064.pdf |
| Author | Mimaki, Yuichi| Fujii, Yoshihiro| Furuno, Katsushi| Gomita, Yutaka| Araki, Yasunori| Tanizaki, Yoshiro| |
| Abstract | 薬物のbioavailabilityに影響する因子の一つとして,製剤からの薬物の溶出速度が考えられる｡今回,温泉水による薬物溶出への影響を知る目的で,気管支喘息治療薬のアミノフィリン製剤およびテオフィリン徐放製剤の溶出挙動について検討した｡溶出試験は第12改正日本薬局方に従い,第1法(回転バスケット法)および第2法(パドル法)で行い,試験液を蒸留水および三朝温泉水として両者の溶出挙動を比較した｡アミノフィリン製剤では,10分後まで 温泉水の方が有意に高い溶出率を示した｡また,テオフィリン徐放製剤においても温泉水が8時間後まで蒸留水に比べて有意に高い溶出率を示した｡以上の結果より,アミノフィリン製剤およびテオフィリン徐放製剤は温泉水により薬物の溶出が促進されることか示唆された。 |
| Keywords | 溶出試験 (Dissolutionte test) 温泉水 (Spring water) 気管支喘息治療薬 (Bronchial asthma therapeutic drug) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 60 |
| End Page | 64. |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307434 |
| JaLCDOI | 10.18926/15314 |
|---|---|
| Title Alternative | 気管支肺胞洗浄液中に一過性の好中球増多をきたしたアトピー型喘息 |
| FullText URL | 064_052_059.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Nakagiri, Yoshiyasu| Tada, Shinya| Kimura, Ikuro| |
| Abstract | Clinical course of one asthma patient (64 years old, female), who had an increased proportion of neutrophils in bronchoalveolar lavage (BAL) fluid, was observed in relation to the proportion of BAL cells and ventilatory function. The patient had large asthma attacks two times during her clinical course for 15 months observed. 1. An increased proportion of BAL neutrophils and suppression of ventilatory function were found after her first large asthma attacks. The increased proportion of BAL neutrophils continued for more than 5 months. A reduction in the proportion of BAL neutrophils was found 3 months after her second large asthma attack, accompanied by improvement of clinical symptoms and ventilatory function. The numbers of total cells and neutrophils in BAL fluid were also reduced. Transient increase in number of BAL lymphocytes was found 13 months after the first large attack when the number of BAL neutrophils was markedly decreased. The number of BAL eosinophils did not change during her clinical course. |
| Keywords | Bronchial asthma (気管支喘息) transient BAL neutrophilia(一過性BAL液中好中球増多) ventilatory function (換気機能) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 52 |
| End Page | 59 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307805 |
| JaLCDOI | 10.18926/15313 |
|---|---|
| FullText URL | 063_034_038.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Kimura, Ikuro| |
| Abstract | The serum levels of total IgE, IgG and IgG(4) were compared among five age groups of patients with bronchial asthma. 1. The level of serum IgE was significantly higher in the patients before the age of 29 than in those between the ages of 30 and 49 (p < 0.02), between 50 and 59 (p < 0.01) and between 60 and 69 (p < 0.01). The serum IgE level tended to increase in the patients over age 70. 2. The serum level of total IgG was significantly higher in the patients over age 70 compared with the level in the 30-49 (p < 0.05) and the 60-69 year old groups (p < 0.05). 3. The serum IgG(4) level was increased with aging, although no significant difference was found among the five age groups. 4. The IgG(4) level correlated to a certain extent with the level of serum IgE. The results reveal that the levels of total IgE, IgG and IgG(4) are increased in the elderly patients over age 70, and that there is a relationship between serum levels of total IgE and IgG(4). |
| Keywords | Total IgE IgG IgG(4) aging bronchial asthma |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 34 |
| End Page | 38 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307767 |
| JaLCDOI | 10.18926/15312 |
|---|---|
| Title Alternative | 老年者気管支喘息における気道炎症細胞.喘息重症度と関連した気道細胞反応の特徴 |
| FullText URL | 064_083_088.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Nakagiri, Yoshiyasu| Harada, Hideo| Kimura, Ikuro| |
| Abstract | Cellular composition of bronchoalveolar lavage (BAL) fluid was examined in 11 elderly asthmatics over the age of 70, and the results were compared with those of 11 younger asthmatics under the age of 50. In the subjects with mild asthma, the proportion of BAL cells in the elderly subjects was 86.2% macrophages, 11.0% lymphocytes, 1.9% neutrophils, 0.9% eosinophils and 0.08% basophilic cells. The proportion of neutrophils and eosinophils in the BAL fluid was slightly higher in younger subjects with mild asthma compared with that in elderly subjects, although no significant difference was found between the two groups. In subjects with severe asthma, the proportions of lymphocytes, neutrophils, eosinophils and basophilic cells were more increased in both younger and older patients compared to those with mild asthma, and a significant increase in the number of BAL eosinophils was found in younger subjects with severe asthma compared to those with mild asthma (p < 0.05). However, no significant difference was present in the proportion of BAL cells between younger and older patients with severe asthma. The results reveal that BAL cells are more increased in subjects with suvere asthma than in those with mild asthma in both younger and older subjects, and show the possibility that this increase is more predominant in neutrophils in older subjects and in eosinophils in younger subjects. |
| Keywords | Neutrophils (好中球) Eosinophils (好酸球) Bronchoalveolar lavage (気管支肺胞洗浄) asthma severity (喘息重症度) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 83 |
| End Page | 88 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307736 |
| JaLCDOI | 10.18926/15311 |
|---|---|
| Title Alternative | 抗原および Ca ionophore A23187 刺激時におけるアトピー型気管支喘息末梢血好塩基球の運動能 |
| FullText URL | 064_043_051.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Ochi, Koji| Harada, Hideo| Nakagawa, Saburo| Soda, Ryo| Takahashi, Kiyoshi| Kimura, Ikuro| |
| Abstract | We examined histamine release and morphological changes in basophilic granulocytes from atopic subjects, in response to stimulation with antigen and Ca ionophore A23187. 1. Histamine release and a reduction in the rumber of basophils were more rapid and greater in extent at an early stage of antigen stimulation compared with Ca ionophore A23187 stimulation. 2. Morphological changes in basophils, represented by increased motility, in terms of an increased ratio of short to long axis diameter (L/S ratio), as well as the increased frequency of basophils with localized granules and those with pseudopods, were more often observed antigen stimulation than with Ca ionophore A23187 stimulation. In contrast, morphogical changes in which basophils appeared swollen, showing an increased mean cell diameter and an increased frequency of cells with 5 vacuoles or more were more predominant with Ca ionophore A23187 than with antigen stimulation. The results obtained here show that bridging of IgE receptors is essential to activate basophils and induce increased motility in these cells. |
| Keywords | histamine release (ヒスタミン遊離) increased basophil motility (好塩基球の運動能の亢進) bridging of IgE receptors (LgE 受容体) antigen (抗原) Ca ionophore A23187 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 43 |
| End Page | 51 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307677 |
| JaLCDOI | 10.18926/15310 |
|---|---|
| Title Alternative | 気管支喘息の臨床分類とその細胞性および液性因子の特徴 |
| FullText URL | 064_036_042.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Nakagiri, Yoshiyasu| Tada, Shinya| Kimura, Ikuro| |
| Abstract | Characteristics of each asthma type classified by clinical symptoms and findings were studied in 72 patients with bronchial asthma. 1. Ventilatory function tests showed that the values of % MMF, % V(50) and % V(25) were significantly lower in patients with bronchiolar obstruction (type II) compared to the values of those with simple bronchoconstriction type (type Ia) and those with bronchoconstriction + hypersecretion (type Ib). 2. The proportion of neutrophils in bronchoalveolar lavage (BAL) fluid was significantly higher in type II than in type Ia and type Ib. Several patients with type Ib showed higher proportion of BAL eosinophils. 3. The release of LTC(4) from leucocytes was significantly lower in type II compared with type Ia and type Ib. There was no significant difference in the release of histamine and LTB(4) among the three asthma types. |
| Keywords | Bronchial asthma Asthma classification BAL fluid chemical mediators |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 36 |
| End Page | 42 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307662 |
| JaLCDOI | 10.18926/15309 |
|---|---|
| Title Alternative | Correlations between bone mineral density measured by QCT and risk factors of Osteoporosis |
| FullText URL | 063_030_033.pdf |
| Author | Honke, Naoko| Kusaura, Yasuhiro| Tanimizu, Masakuni| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Kitani, Hikaru| Tanizaki, Yoshiro| Takatori, Akimasa| Okuda, Hiroyuki| Nakai, Mutsuro| Akiyama, Tsuneo| |
| Abstract | 27～85才の女性143例における骨塩量を,定量的QCT法 (quantitative computed tomography)を用いて測定し,年令,身長,体重及び原疾患(慢性関節リウマチ),使用薬剤(ステロイド･骨強化剤)の因子の骨塩量に及ぼす影響について検討した｡その結果,1)加令とともに骨塩量は低下するが,特に40才代後半から60才代にかけての低下が顕著であり,また, 他因子の影響を受けやすい｡2)体型的因子としては.痩せ型で低身長の人に低値の傾向がある｡3)ステロイド使用の有無における検討において,特に50才代で使用群が著明に低値であることが明らかとなった｡また,薬剤の因子の考察に関しては,さらに経時的検討か必要であると思われた｡ |
| Keywords | 骨粗鬆症 (Osteoporosis) 定量的コンピューター断層法 (QCT (quantitative computed tomograpy)) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 30 |
| End Page | 33 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307603 |
| JaLCDOI | 10.18926/15308 |
|---|---|
| Title Alternative | 老年者気管支喘息における液性および細胞性免疫反応について |
| FullText URL | 064_075_082.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Ochi, Koji| Harada, Hideo| Tada, Shinya| Kimura, Ikuro| |
| Abstract | Humoral and cellular immune responses in bronchial asthma were examined by comparing the results of older asthmatics (group OA) with those of older healthy subjects (group OH) and of younger asthmatics (group YA). In humoral immune response, IgE-mediated immune system expressed by elevated serum IgE levels and IgE antibodies for house dust mite (HDm) and/or Candida albicans was clearly found in older asthmatics, while there was no finding showing the presence of IgE-mediated immune response in older healthy subjects. There was no significant difference in levels of serum IgG and IgA among the three groups. However, the serum IgM level was significantly lower in older asthmatics than in younger asthmatics. IgE antibodies to HDm and/or Candida albicans were more frequently found in older asthmatics compared with older healthy subjects. In contrast, IgG(4) antibodies to HDm were not different among the three groups. IgG(4) antibodies to Candida albicans were significantly higher in both older groups than in younger group. However, there was no significant difference between asthmatic and healthy subjects in the elderly. Delayed skin reaction to PPD was significantly more decreased in older asthmatics. These results show that bronchial asthma in the elderly is characterized by the presence of IgE-mediated immune response and by the changes of immune response with aging. |
| Keywords | IgE IgG(4) Immunoglobulings (免疫グロブリン) PPD Bronchial asthma (気管支喘息) 加齢 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 75 |
| End Page | 82 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307261 |
| JaLCDOI | 10.18926/15307 |
|---|---|
| Title Alternative | 気管支喘息におけるハウスダストアレルギー. 血清IgE値とIgE抗体価と年齢との関連 |
| FullText URL | 064_031_035.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Ochi, Koji| Harada, Hideo| Tada, Shinya| Kimura, Ikuro| |
| Abstract | Serum IgE levels and IgE antibody values in relation to patient age were examined in 50 patients with house dust mite (HDm) sensitive asthma, 1. IgE antibody values to HDm were highest in patients between the ages of 10 and 19, and the values generally low in those over the age of 40. 2. High IgE antibody values to HDm were accompanied by high serum IgE levels in patients between 10 and 19. IgE antibody values and serum IgE levels were in general low in patients over age 40. In patient under age 9, serum IgE levels were less than 500 IU/ml in 5 of the 10 subjects despite an increased value of IgE antibodies to HDm. These results suggest that an increased production of IgE antibodies to HDm is usually accompanied by an increased production of total IgE in younger subjects. However, an increase in production of IgE antibodies is not always related to an increase in production of total IgE in patients under age 9. The results also show that production of IgE antibodies to HDm and total IgE is in general low in older patients despite the hyperreactivity to HDm. |
| Keywords | Serum IgE (血清IgE) IgE antibodies (IgE抗体) house dust mite (ダニ) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 31 |
| End Page | 35 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307674 |
| JaLCDOI | 10.18926/15306 |
|---|---|
| Title Alternative | 気管支喘息における気道内への好中球の出現とその意義 換気機能と関連して |
| FullText URL | 063_025_029.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuharu| Kimura, Ikuro| |
| Abstract | Ventilatory function was compared between two age-matched asthma groups : group A (study group) consists of 8 patients with bronchial asthma with marked neutrophilia (20% or more) in the BAL fluid and group B (control group) of 8 patients with neutrophils (less than 5% of total BAL cells). The values of six ventilatory parameters were lower in group A than in group B, and a significant difference was found in FEV(1.0%), % MMF, % V(50) and % V(25) between groups A and B. Of these parameters, the value of % V(25) was markedly decreased in group A compared with group B. The results show that ventilatory dysfunction in airways, especially in small airways, is closely correlated to increased number of neutrophils in BAL fluid. |
| Keywords | ventilatory function (換気機能) neutrophils in BAL fluid (好中球, BAL) small airways (細気管支) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 25 |
| End Page | 29 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307993 |
| JaLCDOI | 10.18926/15305 |
|---|---|
| Title Alternative | 気管支喘息における気道炎症反応の臨床的意義｡慢性閉塞性細気管支炎との比較検討 |
| FullText URL | 064_024_030.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Ochi, Koji| Harada, Hideo| Tada, Shinya| Kimura, Ikuro| |
| Abstract | Clinical significanoce of airway inflammation was assessed in 28 patients with bronchial asthma, and the results were compared with those in 9 patients with chronic obstructive bronchiolitis (COB). 1. Total cell number in bronchoalveolar lavage(BAL) fluid was markedly increased in patients with COB (51.0×10(6)), which was significantly greater than that in those with bronchial asthma (9.6×10(6) ). 2. The proportion of BAL macrophages was significantly higher in patients with bronchial asthma than in those with COB. However, the, absolute number of BAL macrophages was not significantly different between them. 3. The proportion of BAL lymphocytes was higher in patients with bronchial asthma than in those with COB, but this difference was not signifcant. In contrast, the absolute number of BAL lymphocytes was significantly greater in patients with COB than in those with bronchial asthma. 4. The proportion and the number of BAL neutrophils were markedly increased in patients with COB compared to those with bronchial asthma. 5. The proportion and the number of BAL eosinophils were higher in patients with bronchial asthma than in those with COB, although these defferences were not significant. The results suggest that airway inflammation in bronchial asthma is not so intensive as that in COB. |
| Keywords | airway inflammation (気道炎症反応) bronchial asthma (気管支喘息) chronic obstructive bronchiolitis (慢性閉塞性細気管支炎) lymphocytes (リンパ球) neutrophils (好中球) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 24 |
| End Page | 30 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307730 |
| JaLCDOI | 10.18926/15304 |
|---|---|
| Title Alternative | 気管支喘息における気道内への好酸球の出現とその意義. 過分泌と関連して. |
| FullText URL | 063_014_018.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro| |
| Abstract | A correlation between the proportion of eosinophils in bronochoalveolar lavage (BAL) fluid and amount of expectoration was examined in patients with atopic asthma. The subjects were divided into two groups : cases with high proportion (20% of more) (group A) and low proportion (less than 5%) (group B) of eosinophils in the BAL fluid. Any significant difference was not paesent in the value of each ventilatory parameter between the two groups. The amount of expectoration/day was significantly higher in group A compared with group B (p<0.001). These results suggest that eosinophilia in BAL fluid correlates to mucus hypersecretion in the airways of patients with atopic asthma. |
| Keywords | Eosinophilia (好酸球) Hypersecretion (過分泌) BAL fluid (BAL) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 14 |
| End Page | 18 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307156 |
| JaLCDOI | 10.18926/15303 |
|---|---|
| Title Alternative | 気管支喘息におけるActivated Tリンパ球について,喘息発作との関連 |
| FullText URL | 064_011_016.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Harada, Hideo| Tada, Shinya| Kimura, Ikuro| |
| Abstract | The number of CD4(+) T-Iymphocytes, CD4/CD8 ratio, and the number of IL2R(+) T-Iymphocytes (CD25) were examined in 14 patients with bronchial asthma, and the results were compared in three different asthma stages : symptom-free stage, wheeze stage, and attack stage. 1. The proportion of blood CD4(+) T-lymphocytes was more decreased in patients with asthma attacks than in those without symptoms. The CD4/CD8 ratio was also more decreased in patients with attacks than in those without symptoms. However, these differences were not significant. 2. The proportion of blood activated T cells (IL2R(+) cells, CD25) was significantly increased in patients with attacks than in those without symptoms. The proportion of activated T cells in 5 asthma patients was 2.9±0.8% in symptom-free stage and 6.6±1.1% in attack stage(p<0.001). These findings show that numbers of activated T-lymphocytes in peripheral blood were increased during asthma attacks, and this increase suggests the participation of activated T cells in the pathogenesis of asthma. |
| Keywords | CD4(+) T cells (CD4(+)リンパ球) CD4／CD8 ratio (CD4／CD8比) IL2R(+) T cells (IL2R(+)Tリンパ球) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 11 |
| End Page | 16 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307394 |
| JaLCDOI | 10.18926/15302 |
|---|---|
| Title Alternative | 気管支喘息における気道内リンパ球の出現とその意義.IgE系反応との関連について. |
| FullText URL | 063_019_024.pdf |
| Author | Tanizaki, Yosihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Kimura, Ikuro| |
| Abstract | Relationship of the proportion of lymphocytes in bronchoalveolar lavage (BAL) fiutd to IgE-mediated reactions and to ventilatory function was studied in two age-matched asthma groups : group A of 11 subjects with BAL lymphocytes over 30% and group B of 11 subjects with BAL leyphocytes less than 10%. Of the eleven subjects in group A, 3 (27.3%) were atopic and 4 (36.4%) were non-atopic. The proportion of BAL lymphocytes in subjects with serum IgE level more than 300 IU/ml, who were all older than 50 years, was significantly higher than that in subjects with serum IgE less than 100 IU/ml in group A (p<0.05). While of the eleven subjects of group B, 5 (45.5%) were atopic and 4 (36.4%) were non-atopic. The value of % V(25) was significantly higher in the atopics compared with the non-atopics in group A (p<0.05), although no significant difference was found in the value of % V(25) between the two asthma types in group B. The results show that an increased number of lymphocytes in BAL fluid may be enhanced by IgE-mediated allergic reactions in the elderly, and that the decreased value of % V(25) may be associated withan increased number of lymphocytes in BAL fluid in non-atopics. |
| Keywords | Lymphocytes (リンパ球) BAL fluid (BAL液) IgE antibody (IgE抗体) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 19 |
| End Page | 24 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307202 |
| JaLCDOI | 10.18926/15301 |
|---|---|
| Title Alternative | 気管支喘息における副腎皮質ホルモン長期投与による免疫抑制と気管支肺胞洗浄液中好中球増多との関連 |
| FullText URL | 064_017_023.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Harada, Hideo| Kimura, Ikuro| |
| Abstract | Cellular composition of bronchoalveolar lavage (BAL) fluid was compared between two age-matched steroid-dependent intractable asthma (SDIA) groups : 17 group A patients (serum IgG level < 1000mg/dℓ) whose immunity was regarded as being suppressed by long-term glucocorticoid therapy and 17 group B patients (serum IgG level > 1200mg/dℓ). 1. The levels of serum IgA and IgM were significantly decreased in group A compared to the levels in group B patients. 2. The number of blood lymphocytes was also significantly lower in group A than in group B patients. However, the number of blood neutrophils was not different between the two asthma groups. 3.The number of BAL lymphocytes was significantly lower in group A than in group B patients. 4. BAL neutrophilia (more than 1.5×10 (4)/mℓ) was observed in 6 of the 17(35.3%) patients in group A, but not observed in any patients in group B. The number of BAL neutrophils was significantly greater in group A than in group B patients. These results suggest that there is a correlation between immunosuppression by glucocorticoids and BAL neutrophilia in patients with bronchial asthma. |
| Keywords | immunosuppression (免疫抑制) BAL neutrophilia (BAL好中球増多) glucocorticoids (副腎皮質ホルモン) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 17 |
| End Page | 23 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307882 |
| JaLCDOI | 10.18926/15300 |
|---|---|
| Title Alternative | Clinical effects of spa therapy on bronchial asthma. |
| FullText URL | 063_007_013.pdf |
| Author | Mifune, Takashi| Kusaura, Yasuhiro| Honke, Naoko| Tanimizu, Masahiro| Mitunobu, Fumihiro| Okazaki, Morihiro| Kitani, Hikaru| Tanizaki, Yoshiro| |
| Abstract | ステロイド依存性重症難治性喘息を中心に,喘息に対する温泉療法の臨床効果を,症例の背景因子に基づいて検討した｡1.現年令あるいは発症年令が高い症例でより有効であった｡2.非アトピー性の症例において有効率が高率であった｡3.臨床病型別では,細気管支閉塞型において最も有効率が高く,17例中16例(94.1%)が有効であった｡4.ステロイド減量効果は.71症例中43例(60.6%)で認められた｡細気管支閉塞型の症例でステロイド減量不能の症例を多く認めた｡ |
| Keywords | 気管支喘息 (Bronchial asthma) 温泉療法 (Spa therapy) 臨床病型 (clinical asthmaty) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 7 |
| End Page | 13 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307411 |
| JaLCDOI | 10.18926/15299 |
|---|---|
| Title Alternative | ステロイド依存性重症難治性喘息に対する温泉療法の重要性｡過去10年間の181例を対象に。 |
| FullText URL | 064_001_010.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Ochi, Koji| Harada, Hideo| Tada, Shinya| Kimura, Ikuro| |
| Abstract | Characteristics of 181 patients with steroid-dependent intractable asthma (SDIA) who were admitted to our hospital and had spa therapy for last 10 years were examined in relation to the methods of spa therapy. For last 10 years, three kinds ofspa therapies were administered: spa therapy A (swimming training in a hot spring pool) in the first atage (1982-1985), spa therapy B (swimming training + inhalation of iodine salt solution) in the middle stage (1986 -1989), and spa therapy C (swimming training + inhalation of iodine salt solution + fango therapy) in the last stage (1990-1991) of this study. 1. The number of patients with SDIA who were admitted to our hospital and had spa therapy tended to increase from 2 in 1986 to 35 in 1991. 2. The number of SDIA patients over the age of 60 or over the age at onset of 40 tended to increase from the first stage to the last stage. 3. The proportion of patients from distant areas (prefectures other than Tottori) was decreasing for the last stage, although the number of these patients was increasing in recent years. 4. The proportions of patients divided by serum IgE levels and by clinical asthma types did not change for last 10 years. 5. The proportion of type Ib and type II asthma was considerably high in patients with SDIA for last 10 years. 6. Clinical effects of spa therapy were observed in 21 of the 30 (70.0%)patients with SDIA in the first stage (1982-1985) with spa therapy A, 68 of the 83 (74.7%) patients with SDIA in the middle stage (1986-1989) with spa therapy B, and 61 of the 68 (89.7%) patients with SDIA in the last stage (1990-1991) with spa therapy C. |
| Keywords | swimming training in a hot spring pool (温泉プール水泳訓練) inhalation of iodine salt solution (ヨードゾル吸入) fango therapy (鉱泥湿布療法) SDIA |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 1 |
| End Page | 10 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307391 |
| JaLCDOI | 10.18926/15298 |
|---|---|
| Title Alternative | ステロイド依存性重症難治性喘息に対する複合温泉療法の作用機序 |
| FullText URL | 063_001_006.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Takatori, Akimasa| Okuda, Hiroyuki| Ochi, Koji| Harada, Hideo| Kimura, Ikuro| |
| Abstract | Effects of complex spa therapy, which comprises swimming training in a hot spring pool, inhalation of iodine salt solution and fango therapy, were analyzed in patients with steroid-dependent intractable asthma (SDIA) by comparison between the subjects with and without efficacy of the therapy. 1. The complex spa therapy was effective in the patients with lower levels of FEV(1.0%) and % PEFR. 2. The complex spa therapy was not always effective in the patients with a low value of % V(25), which represents depressed airflow in the small airways. 3. The efficacy of the complex spa therapy was found in the patients showing a low value of % V(25) accompanied by BAL neutrophilia, but not found in those without increased proportion (more than 10% ) of neutrophils in BAL fluid. The results reveal that the complex spa therapy is effective in patients with SDIA showing low values of FEV(1.0%) and % PEFR, and in those with a low value of % V(25) and BAL neutrophilia. |
| Keywords | complex spa therapy (複合温泉療法) ventilatory function (換気機能) BAL neutrophilia (BAL好中球増多) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307537 |
| JaLCDOI | 10.18926/15295 |
|---|---|
| Title Alternative | A study on actual conditions of care for the elderly in urban and rural areas of Okayama prefecture |
| FullText URL | 007_2_149_157.pdf |
| Author | Ohta, Niwa| |
| Abstract | 高齢者の在宅ケアの必要性が増大している一方,女性の就労者の増加や核家族化は在宅でのケアを困難にしている。そこで,実際にどのような現状や問題があるのかを検討する必要があると考えた｡今回,全国の高齢化率(14.1%)より高い高齢化率(16.9%)の岡山県で,在宅ケアの実態を1995年8月から9月にかけて調査した｡都市部(岡山市)･農村部(高梁市･邑久町･久米南町)で比較すると,在宅ケアは都市部に比べ農村部が少なく,農村部では施設での介護の方が多いことを認めた｡分析対象は140名で都市部が39名,農村部が101名である｡在宅でケアを受ける75歳以上の高齢者は77.1%と多かった｡農村部の方が高年齢で障害度も重く,特に過疎地域では介護期間も長く5年以上が過半数を占めていた｡主たる介護者は都市部では配偶者が63%と多かった｡過疎の農村部では息子の妻および孫の妻が多く,また70歳以上の高齢の介護者が3分の1を占めていた｡入浴･更衣回数などのケア回数は県北の農村部では特に少なかった｡また家族の介護時間は都市部は1日につき約7時間であったが,農村部では約3時間のみであった｡保健婦･看護婦などの専門職者によるサービスは都市部に多く,ホームヘルパーによるサービスは農村部に多かった。民間のサービス利用率は都市部･農村部いづれも低かった｡以上のごとく農村部における高齢者の介護がより問題が多く,深刻な状況であることが明らかになった｡ |
| Keywords | 高齢者 (the elderly) 在宅ケア (home care) 都市部 (urban area) 農村部 (rural area) 岡山県 (Okayama prefecture) |
| Publication Title | 岡山大学医療技術短期大学部紀要 |
| Published Date | 1997-01-31 |
| Volume | volume7 |
| Issue | issue2 |
| Start Page | 149 |
| End Page | 157 |
| ISSN | 0917-4494 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307982 |
