result 749 件
| FullText URL | J_ChemPhys_151_064702_p.pdf |
|---|---|
| Author | Yagasaki, Takuma| Yamasaki, Masaru| Matsumoto, Masakazu| Tanaka, Hideki| |
| Note | This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Takuma Yagasaki et. al. Formation of hot ice caused by carbon nanobrushes. The Journal of Chemical Physics 151(6), 064702 (2019)(citation of published article) and may be found at https://doi.org/10.1063/1.5111843.| |
| Published Date | 2019-08-08 |
| Publication Title | The Journal of Chemical Physics |
| Volume | volume151 |
| Issue | issue6 |
| Publisher | American Institute of Physics |
| Start Page | 064702 |
| ISSN | 00219606 |
| NCID | AA00694991 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright (2019) Author(s) |
| File Version | publisher |
| DOI | 10.1063/1.5111843 |
| Related Url | isVersionOf https://doi.org/10.1063/1.5111843 |
| FullText URL | J_Chem_Phys_150_21_214504.pdf J_Chem_Phys_150_21_214504_p.pdf |
|---|---|
| Author | Matsumoto, Masakazu| Yagasaki, Takuma| Tanaka, Hideki| |
| Published Date | 2019-06-05 |
| Publication Title | Journal of Chemical Physics |
| Volume | volume150 |
| Issue | issue21 |
| Publisher | American Institute of Physics |
| Start Page | 214504 |
| ISSN | 0021-9606 |
| NCID | AA00694991 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright 2019 Author(s). |
| File Version | author |
| PubMed ID | 31176318 |
| DOI | 10.1063/1.5096556 |
| Related Url | isVersionOf https://doi.org/10.1063/1.5096556 |
| FullText URL | Allergol_Int_201908007.pdf |
|---|---|
| Author | Matsumoto, Naomi| Yorifuji, Takashi| Nakamura, Kazue| Ikeda, Masanori| Tsukahara, Hirokazu| Doi, Hiroyuki| |
| Keywords | Breastfeeding Cohort Colostrum Eczema Food allergy |
| Published Date | 2019-09-17 |
| Publication Title | Allergology International |
| Publisher | Elsevier |
| ISSN | 13238930 |
| NCID | AA11091750 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 Japanese Society of Allergology. Production and hosting by Elsevier B.V. |
| File Version | publisher |
| PubMed ID | 31540813 |
| DOI | 10.1016/j.alit.2019.08.007 |
| Related Url | isVersionOf https://doi.org/10.1016/j.alit.2019.08.007 |
| FullText URL | Biomed_Pharmacother_2019109038.pdf |
|---|---|
| Author | Ueno, Hiroshi| Suemitsu, Shunsuke| Murakami, Shinji| Kitamura, Naoya| Wani, Kenta| Takahashi, Yu| Matsumoto, Yosuke| Okamoto, Motoi| Ishihara, Takeshi| |
| Keywords | Inhalation Dizocilpine MK-801 Mouse Drug Schizophrenia |
| Published Date | 2019-09-30 |
| Publication Title | Biomedicine & Pharmacotherapy |
| Volume | volume117 |
| Publisher | Elsevier |
| Start Page | 109038 |
| ISSN | 07533322 |
| NCID | AA10506249 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. Published by Elsevier Masson SAS. |
| File Version | publisher |
| PubMed ID | 31177060 |
| DOI | 10.1016/j.biopha.2019.109038 |
| Web of Science KeyUT | 000477804500018 |
| Related Url | isVersionOf https://doi.org/10.1016/j.biopha.2019.109038 |
| FullText URL | PMU8_41.pdf Fig.pdf Suppl.pdf |
|---|---|
| Author | Matsumoto, Jun| Nakamura, Hiroyoshi| San, Su Nwe| Sato, Hikari| Takezawa, Manami| Kishi, Ryuto| Kito, Yutaro| Sugano, Junko| Izuki, Mai| Yanagisawa, Nao| Ikeda, Naoki| Saito, Yusuke| Kato, Yoshinori| Yamada, Harumi| Fujiyoshi, Masachika| Ariyoshi, Noritaka| |
| Keywords | CYP3A CYP3A5*3 allele P450 Glo Assay system Pharmacokinetics Pharmacogenetics |
| Published Date | 2019-07-31 |
| Publication Title | Personalized Medicine Universe |
| Volume | volume8 |
| Publisher | Elsevier B.V. |
| Start Page | 41 |
| End Page | 44 |
| ISSN | 21867070 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1016/j.pmu.2019.04.001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.pmu.2019.04.001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ueno, Hiroshi| Shimada, Atsumi| Suemitsu, Shunsuke| Murakami, Shinji| Kitamura, Naoya| Wani, Kenta| Takahashi, Yu| Matsumoto, Yosuke| Okamoto, Motoi| Fujiwara, Yuko| Ishihara, Takeshi| |
| Keywords | Anti-nociceptive Vanillin Essential oil Inhalation Analgesia |
| Published Date | 2019-07 |
| Publication Title | Biomedicine and Pharmacotherapy |
| Volume | volume115 |
| Publisher | Elsevier |
| Start Page | 108879 |
| ISSN | 0753-3322 |
| NCID | AA10506249 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. |
| File Version | publisher |
| PubMed ID | 31035009 |
| DOI | 10.1016/j.biopha.2019.108879 |
| Web of Science KeyUT | 000470664600018 |
| Related Url | isVersionOf https://doi.org/10.1016/j.biopha.2019.108879 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ueno, Hiroshi| Suemitsu, Shunsuke| Murakami, Shinji| Kitamura, Naoya| Wani, Kenta| Matsumoto, Yosuke| Okamoto, Motoi| Ishihara, Takeshi| |
| Keywords | Extracellular matrix Perineuronal nets Piriform cortex Proteoglycans Somatosensory cortex Wisteria floribunda |
| Published Date | 2019-06 |
| Publication Title | IBRO Reports |
| Volume | volume6 |
| Publisher | Elsevier |
| Start Page | 1 |
| End Page | 17 |
| ISSN | 24518301 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2018 The Authors. |
| File Version | publisher |
| PubMed ID | 30582064 |
| DOI | 10.1016/j.ibror.2018.11.006 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ibror.2018.11.006 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ueno, Hiroshi| Shimada, Atsumi| Suemitsu, Shunsuke| Murakami, Shinji| Kitamura, Naoya| Wani, Kenta| Matsumoto, Yosuke| Okamoto, Motoi| Fujiwara, Yuko| Ishihara, Takeshi| |
| Keywords | Neuroscience Physiology |
| Published Date | 2019-06 |
| Publication Title | Heliyon |
| Volume | volume5 |
| Issue | issue6 |
| Publisher | Elsevier |
| Start Page | e01945 |
| ISSN | 2405-8440 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. |
| File Version | publisher |
| PubMed ID | 31431930 |
| DOI | 10.1016/j.heliyon.2019.e01945 |
| Web of Science KeyUT | 000473818300016 |
| Related Url | isVersionOf https://doi.org/10.1016/j.heliyon.2019.e01945 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hayami, Hiroshi| Takahashi, Satoshi| Ishikawa, Kiyohito| Yasuda, Mitsuru| Yamamoto, Shingo| Wada, Koichiro| Kobayashi, Kanao| Hamasuna, Ryoichi| Minamitani, Shinichi| Matsumoto, Tetsuya| Kiyota, Hiroshi| Tateda, Kazuhiro| Sato, Junko| Hanaki, Hideaki| Masumori, Naoya| Nishiyama, Hiroyuki| Miyazaki, Jun| Fujimoto, Kiyohide| Tanaka, Kazushi| Uehara, Shinya| Matsubara, Akio| Ito, Kenji| Hayashi, Kenji| Kurimura, Yuichiro| Ito, Shin| Takeuchi, Toshimi| Narita, Harunori| Izumitani, Masanobu| Nishimura, Hirofumi| Kawahara, Motoshi| Hara, Makoto| Hosobe, Takahide| Takashima, Kenji| Chokyu, Hirofumi| Matsumura, Masaru| Ihara, Hideari| Uno, Satoshi| Monden, Koichi| Sumii, Toru| Kawai, Shuichi| Kariya, Satoru| Sato, Takashi| Yoshioka, Masaru| Kadena, Hitoshi| Matsushita, Shinji| Nishi, Shohei| Hosokawa, Yukinari| Shirane, Takeshi| Yoh, Mutsumasa| Watanabe, Syuji| Makinose, Shinichi| Uemura, Tetsuji| Goto, Hirokazu| |
| Keywords | Surveillance Susceptibility Resistance Acute uncomplicated cystitis |
| Published Date | 2019-06 |
| Publication Title | Journal of Infection and Chemotherapy |
| Volume | volume25 |
| Issue | issue6 |
| Publisher | Elsevier |
| Start Page | 413 |
| End Page | 422 |
| ISSN | 1341-321X |
| NCID | AA11057978 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. |
| File Version | publisher |
| PubMed ID | 30905628 |
| DOI | 10.1016/j.jiac.2019.02.021 |
| Web of Science KeyUT | 000466427000002 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jiac.2019.02.021 |
| Title Alternative | A Morgagni hernia repaired laparoscopically using Ventralight ST® mesh |
|---|---|
| FullText URL | 131_35.pdf |
| Author | Murakami , Takayoshi | Fujimoto , Yoshimi | Murashima , Nobutaka | Nishina, Takuya | Sugiu, Kumi| Matsumoto, Takamasa | |
| Abstract | A 78-year-old Japanese woman was referred to our hospital because of fecal occult blood. Barium enema and CT colonography revealed the herniation of the transverse colon and the greater omentum into the right hemithorax through a retrosternal defect. We diagnosed a Morgagni hernia, and we performed a laparoscopic hernia repair with a three-port approach. The invaginated transverse colon and omentum were easily reduced into the abdominal cavity. The size of the hernial orifice was estimated to be approx. 2.5×4 cm. We placed Ventralight ST® mesh over the hernial orifice without hernial sac resection, and we used the double-crown technique to fix the mesh with a hernia stapler. The postoperative course was uneventful, and the patient was discharged on the 5th postoperative day with no complications. There has been no recurrence at 2 years after the surgery. Laparoscopic repair is a safe, less-invasive and useful method for repairing a Morgagni hernia. |
| Keywords | Morgagni 孔ヘルニア (Morgagni hernia) 胸骨後ヘルニア (retrosternal hernia) 腹腔鏡下手術 (laparoscopic repair) Ventralight ST® |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2019-04-01 |
| Volume | volume131 |
| Issue | issue1 |
| Start Page | 35 |
| End Page | 39 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.131.35 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2019 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.131.35 |
| NAID | 130007642656 |
| JaLCDOI | 10.18926/AMO/56939 |
|---|---|
| FullText URL | 73_4_361.pdf |
| Author | Watanabe, Ayako| Kadowaki, Yoshihiko| Hattori, Kenji| Ohmori, Mika| Tsukayama, Hiroyuki| Kubota, Nobuhito| Okumoto, Tatsuo| Ishido, Nobuhiro| Okino, Takeshi| |
| Abstract | A 35-year-old man was referred to our hospital for chronic abdominal pain and diarrhea. Computed tomography showed wall thickening, poor contrast enhancement and calcification of the ascending colon, which were consistent with phlebosclerotic colitis. Malignant character was not detected from a biopsy specimen. Operatively, we observed a scirrhous mass of the ascending colon invading surrounding tissue, which was diagnosed as signet ring cell carcinoma based on analysis of an intraoperative frozen section. Right hemicolectomy with regional lymph node dissection was performed. This case was extremely similar to phlebosclerotic colitis in clinical findings; surgical resection was required for correct diagnosis. |
| Keywords | phlebosclerotic colitis colorectal cancer signet ring cell carcinoma young colorectal cancer |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 361 |
| End Page | 365 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439960 |
| JaLCDOI | 10.18926/AMO/56937 |
|---|---|
| FullText URL | 73_4_349.pdf |
| Author | Isozaki, Hiroshi| Yamamoto, Yasuhisa| Murakami, Shigeki| Matsumoto, Sasau| Takama, Takehiro| |
| Abstract | To clarify the surgical outcomes of breast cancer patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) by core needle biopsy (CNB) (abbreviated as CNBDCIS), we retrospectively analyzed the cases of 131 patients with CNBDCIS who underwent surgery at Oomoto Hospital (32 total mastectomies, 99 conservative mastectomies). Our analysis of underestimation and predictors of invasive breast cancer of CNBDCIS revealed that the underestimation rate of CNBDCIS was 40.5% (53/131). A logistic regression analysis revealed that palpable tumors (yes to no, odds ratio [OR] 3.25), mammography (MMG) category group (category 4 or 5 to categories 1 , 2, or 3, OR 4.69) and MMG microcalcifications (no to yes, OR 0.24) were significant predictive factors for CNBDCIS invasion. In our analysis of the predictors of positive margins during CNBDCIS surgery, 36 (27.5%) of the 131 patients had positive margins after postoperative pathological examination. A logistic regression analysis revealed that the operative procedure (conservative surgery to total mastectomy, OR 21.4) and MMG microcalcifications (yes to no, OR 3.35) were significant factors related to positive margins during CNBDCIS surgery. Thus, MMG microcalcifications are a negative predictor of upgrading of CNBDCIS and a positive predictor of positive surgical margins for CNBDCIS. |
| Keywords | ductal carcinoma in situ core needle biopsy underestimation positive margins microcalcifications on mammography |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 349 |
| End Page | 356 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439958 |
| JaLCDOI | 10.18926/AMO/56930 |
|---|---|
| FullText URL | 73_4_285.pdf |
| Author | Otani, Yoshihiro| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| Abstract | Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion. |
| Keywords | glioma cytoskeletons invasion microtubules |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439951 |
| FullText URL | rpkj_2019_prelim.pdf |
|---|---|
| Author | Nakatani, Ayami| Matsumoto, Naoko| Mitsumoto, Jun| |
| Publication Title | 岡山大学文学部プロジェクト研究「ジェンダーの多層性に関する領域横断的研究」記録集 |
| Published Date | 2019-03-29 |
| language | Japanese |
| File Version | publisher |
| FullText URL | Tissue_Eng_A_2018_0348.pdf |
|---|---|
| Author | Sogawa, Chiharu| Eguchi, Takanori| Okusha, Yuka| Ono, Kisho| Ohyama, Kazumi| Iizuka, Motoharu| Kawasaki, Ryu| Hamada, Yusaku| Takigawa, Masaharu| Sogawa, Norio| Okamoto, Kuniaki| Kozaki , Ken-ichi| |
| Keywords | 3D tumoroid reporter assay Wnt/β-catenin signaling cancer metastasis metalloproteinase syngeneic transplantation tumoroid (tumor organoid) |
| Note | This is an Accepted Manuscript of an article published by Mary Ann Liebert| |
| Published Date | 2019-02-08 |
| Publication Title | Tissue Engineering Part A. |
| Volume | volume25 |
| Issue | issue19-20 |
| Publisher | Mary Ann Liebert |
| Start Page | 1413 |
| End Page | 1425 |
| ISSN | 19373341 |
| NCID | AA12306003 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 30734664 |
| DOI | 10.1089/ten.TEA.2018.0348 |
| NAID | 120006788780 |
| Web of Science KeyUT | 000489035900008 |
| Related Url | isVersionOf https://doi.org/10.1089/ten.TEA.2018.0348 |
| JaLCDOI | 10.18926/ESR/56692 |
|---|---|
| Title Alternative | Synoptic climatological analyses on the large day-to-day variation of air temperature around Germany in winter (Relating to the “seasonal feeling” in “Fasnacht”, the festival for driving the winter away) |
| FullText URL | esr_025_007_017.pdf |
| Author | Hamaki, Tatsuya| Kato, Kuranoshin| Otani, Kazuo| Kato, Haruko| Matsumoto, Kengo| |
| Abstract | Synoptic climatological analyses associated with the large day-to-day variation of air temperature around Germany in winter were performed based mainly on the NCEP/NCAR reanalysis data for 2000/2001 to 2010/2011 winters, with an interest in the relationship to the “seasonal feeling” in “Fasnacht”, the festival for driving the winter away. The intermittent appearance of the extremely cold days with rather large day-to-day variation in winter as pointed out by Kato et al. (2017) for around Germany was seen also to the north and to the east of Germany. According to a case study for the 2000/2001 winter, such large daily mean temperature fluctuation was closely related to the intraseasonal variation of the Icelandic low with about one month period, i.e., while the temperature around Germany was relatively higher at the eastward shift phase of the Icelandic low due to the strong warm air advection by the SW-ly wind, the temperature was extremely low there when the Icelandic low was weakened and retreated westward. |
| Keywords | Comparative climatology Climate around Europe Synoptic climatology on daily temperature variation in winter around Germany seasonal cycle and “seasonal feeling” |
| Publication Title | Okayama University Earth Science Report |
| Published Date | 2018-12-27 |
| Volume | volume25 |
| Issue | issue1 |
| Start Page | 7 |
| End Page | 17 |
| ISSN | 1340-7414 |
| language | Japanese |
| Copyright Holders | © 2018 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| File Version | publisher |
| Title Alternative | The 2017 Incentive Award of the Okayama Medical Association in Cancer Research (2017 Hayashibara Prize and Yamada Prize) |
|---|---|
| FullText URL | 130_117.pdf |
| Author | Otani, Yoshihiro| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-12-03 |
| Volume | volume130 |
| Issue | issue3 |
| Start Page | 117 |
| End Page | 118 |
| ISSN | 0030-1558 |
| Related Url | references https://doi.org/10.1038/onc.2017.373 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.117 |
| NAID | 130007542865 |
| JaLCDOI | 10.18926/AMO/56462 |
|---|---|
| FullText URL | 73_1_77.pdf |
| Author | Morita, Mio| Matsumoto, Hiroshi| Shirakawa, Yasuhiro| Noma, Kazuhiro| Tanabe, Shunsuke| Kimata, Yoshihiro| |
| Abstract | Anterior cervical plate fixation is a common surgical treatment for cervical spine trauma, disc herniation, or cervical spondylosis. Esophageal perforation following anterior cervical plate fixation is a rare but serious complication. Management of esophageal perforation is controversial; however, we suggest treating most cases surgically because this condition is slow to heal and often fatal. We managed 2 cases of esophageal perforation following anterior cervical plate fixation by flap reconstruction with the pectoralis major muscle in one case and a jejunal free flap in the other. Here, we report our experience and review the surgical indications. |
| Keywords | anterior cervical plate fixation esophageal perforation reconstruction pectoralis major flap jejunal free flap |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 77 |
| End Page | 80 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820058 |
| JaLCDOI | 10.18926/AMO/56456 |
|---|---|
| FullText URL | 73_1_29.pdf |
| Author | Matsumoto, Atsushi| Nakamura, Takehiro| Shinomiya, Aya| Kawakita, Kenya| Kawanishi, Masahiko| Miyake, Keisuke| Kuroda, Yasuhiro| Keep, Richard F.| Tamiya, Takashi| |
| Abstract | Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS. |
| Keywords | biomarker histidine-rich glycoprotein predictor subarachnoid hemorrhage vasospasm |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 29 |
| End Page | 39 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820052 |
| JaLCDOI | 10.18926/AMO/56453 |
|---|---|
| FullText URL | 73_1_7.pdf |
| Author | Fukumori, Norio| Sonohata, Motoki| Kitajima, Masaru| Kawano, Shunsuke| Kurata, Tsuyoshi| Sakanishi, Yuta| Sugioka, Takashi| Mawatari, Masaaki| |
| Abstract | We evaluated the analgesic effects of multimodal pain control in which intravenous acetaminophen (IV APAP) was added to the standard protocol for Japanese patients who had undergone a total hip arthroplasty (THA). We performed a retrospective cohort study of 180 patients aged 66.4±10.5 years (30% male) who had undergone a THA (Oct. 2014 to Feb. 2015) at our hospital. The control patients were administered the standard analgesic protocol: flurbiprofen axetil as a continuous intravenous infusion and oral celecoxib (NAPAP; n=109). The patients in the new analgesic protocol group received IV APAP in addition to the standard analgesic protocol (APAP; n=71). The primary outcome was the maximum value of postoperative pain the patients reported on a numerical rating scale (NRS) during the first 24 h post-surgery. A univariate analysis and multivariate analyses adjusted for age, sex, the stage of hip osteoarthritis, preoperative pain, and surgical time showed that the maximum postoperative pain NRS scores during the first 24 h after surgery was significantly lower when the APAP protocol was used. The addition of IV APAP to the current standard multimodal analgesia protocol for Japanese patients who have undergone a THA may decrease the patients’ postoperative pain. |
| Keywords | intravenous acetaminophen postoperative pain total hip arthroplasty osteoarthritis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 7 |
| End Page | 14 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820049 |
