| ID | 11641 |
| Eprint ID | 11641
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| FullText URL | |
| Title Alternative | Ｔ細胞性造血器腫瘍において過剰発現が認められるHelios short isoformの機能解析
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| Author |
Tabayashi, Takayuki
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| Abstract | In an earlier report, we demonstrated overexpression of a short isoform of Helios, Hel-5, which lacks three of four N-terminal zinc fingers, in patients with adult T-cell leukemia/lymphoma. Here, we characterized Hel-5 using immunoprecipitation, and gel shift and luciferase promoter assays, and found that Hel-5 lacks the repressor function observed with a full-length isoform of Helios. Moreover, Hel-5 associates with the full-length isoforms of the Ikaros gene family, Ikaros, Aiolos and Helios, and inhibits their DNA binding activity when present in excess, leading to dominant-negative effects on the full-length isoforms of the Ikaros gene family. Our results suggest a critical role for Helios in the mechanism of leukemogenesis.
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| Keywords | Mutation
Carcinogenesis
Multivariate analysis
Case-control study
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| Note | http://dx.doi.org/10.1111/j.1349-7006.2006.00372.x
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| Published Date | 2007-03-23
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| Publication Title | |
| Content Type |
Thesis or Dissertation
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| Grant Number | 甲第3299号
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| Granted Date | 2007-03-23
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| Thesis Type |
Doctor of Philosophy in Medical Science
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| Grantor | 岡山大学
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| Official Url | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17297655&dopt=Abstract
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| language |
Japanese
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| File Version | none
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| Refereed |
Unknown
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