精神疾患者体液くえん酸量 第2編 ぶどう糖蔗糖経口投与および食事による血清くえん酸量の変化

The author carried out periodically follow-up studies on the changes of citric acid concentration in serum of various psychotic patients after oral administration of glucose, saccarose and food; and obtained the following results. After the oral administration of glucose, those that showed abnormal responses, namely, delayed responses, were the chronic schizophrenic and the acute excitator schizophrenic patients. Since these abnormal responses are observable in diabetic patients as wall as in the children with fits of convulsion, from the standpoint of the citric acid metabolism it is assumed that there is some correlation between these two groups mentioned above. In the case of oral administration of saccarose, a transient increase of the citric acid concentration in blood can be recognized contrary to the case in glucose administration. Abnormal response has been recognized in one of acute excitatory schizophrenic patients. After taking food, a certain number of shizophrenic patients show abnormal nesponses. From these findings, in schizophrenic patients biochemically no metabolic abnormalities can be recognized at the onset of disease, but with gradual chronic deterioration irreversible metabolic abnormalities seem to occur.