result 8456 件
| JaLCDOI | 10.18926/AMO/54187 |
|---|---|
| FullText URL | 70_2_89.pdf |
| Author | Umehara, Norifumi| Mitani, Shigeru| Namba, Yoshifumi| |
| Abstract | Total hip arthroplasty (THA) is an established treatment approach with which good recovery is expected in patients. However, the postoperative satisfaction of THA patients, and factors that affect their treatment outcomes are unclear. We investigated 125 Japanese patients who underwent a primary THA between January 2011 and August 2013. The posterolateral (PL) and muscle-sparing anterolateral (AL) surgical approaches were used. THA outcomes were evaluated using the Short Form-36 (SF-36) at preoperatively and 1 month, 3 months, 6 months, and 1 year postoperatively. Approach-based comparisons demonstrated a significantly higher mean score for physical functioning after 6 months, role physical at 1 year, and social functioning at 1 year in the AL group. No significant difference was observed for other subscale scores at any survey period. The age-based comparison often indicated significant increases of subscale scores in the younger patient group. Weight-based comparisons were not observed for any of the 8 subscales at any survey period. Surgical approach was not a factor affecting the patients’ postoperative quality of life, and the AL approach was not superior to the other surgical approaches involving myotenotomy. Moreover, the THA treatment outcomes were better in the younger patients, and obesity did not affect the outcomes. |
| Keywords | total hip arthroplasty quality of life approach |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-04 |
| Volume | volume70 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 89 |
| End Page | 95 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27094833 |
| Web of Science KeyUT | 000377626300003 |
| JaLCDOI | 10.18926/AMO/54186 |
|---|---|
| FullText URL | 70_2_75.pdf |
| Author | Sejima, Hiroe| Satoh, Shinya| Dansako, Hiromichi| Honda, Masao| Kaneko, Shuichi| Ikeda, Masanori| Kato, Nobuyuki| |
| Abstract | The mechanisms of hepatitis C virus (HCV)-associated hepatocarcinogenesis and disease progression are unclear. We previously observed that the expression level of carboxypeptidase B2 (CPB2) gene was remarkably suppressed by persistent HCV RNA replication in human hepatoma cell line Li23-derived cells. The results of the present study demonstrated that the CPB2 expression in patients with chronic hepatitis C was inversely correlated with several risk factors of hepatic fibrosis or steatosis, although ectopic CPB2 expression did not suppress the expression of fibrogenic or lipogenic genes. The suppressed CPB2 expression was restored by treatment with 5-azacytidine. To clarify the mechanism underlying this phenomenon, we analyzed the CPB2 promoter, and the results revealed that (1) hepatocyte nuclear factor 1 (HNF1), especially HNF1α, was essential for the CPB2 promoter, and (2) CPB2 promoter was not methylated by persistent HCV RNA replication. The expression levels of HNF1α and HNF1β were also not changed by persistent HCV RNA replication. These results suggest the existence of 5-azacytidine-inducible or -reducible unknown factor(s) that can control the CPB2 expression. To evaluate this idea we performed a microarray analysis, and several gene candidates corresponding to the suggested factor(s) were identified. |
| Keywords | persistent hepatitis C virus replication carboxypeptidase B2 suppression mechanism of CPB2 expression DNA methylation hepatocyte nuclear factor 1 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-04 |
| Volume | volume70 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 75 |
| End Page | 88 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27094832 |
| Web of Science KeyUT | 000377626300002 |
| JaLCDOI | 10.18926/AMO/54185 |
|---|---|
| FullText URL | 70_2_69.pdf |
| Author | Kobayashi, Yasuyuki| Kurahashi, Hiroaki| Matsumoto, Yuko| Wada, Koichiro| Sasaki, Katsumi| Araki, Motoo| Ebara, Shin| Watanabe, Toyohiko| Nasu, Yasutomo| |
| Abstract | In minimally invasive partial nephrectomy (MIPN), it is important to preoperatively predict the degree of difficulty of tumor resection. When severe adhesions occur between the renal capsule and perinephric adipose tissue, detachment can be difficult. Preoperative prediction of adhesion is thought to be useful in the selection of surgical procedure. Subjects were 63 patients of a single surgeon who had received MIPN between April 2008 and August 2013 at Okayama University Hospital. Of these patients, this study followed 47 in whom the presence or absence of adhesions between the renal capsule and perinephric adipose tissue was confirmed using intraoperative videos. Data collected included: sex, BMI, CT finding (presence of fibroids in perinephric adipose tissue), comorbidities and lifestyle. Adhesion was observed in 7 patients (14.9%). The mean operative time was 291.6min in the adhesion group, and 226.3min in the group without. The increased time in the adhesions group was significant (p＜0.05). Predictive factors were a positive CT finding for fibroid structure and comorbidity of hypertension (p＜0.05). In MIPN, difficulty of surgery can be affected by the presence of adhesion of the perinephric adipose tissue. Predicting such adhesion from preoperative CT is thus important. |
| Keywords | renal cell carcinoma partial nephrectomy renal capsule adhension |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-04 |
| Volume | volume70 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 69 |
| End Page | 74 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27094831 |
| Web of Science KeyUT | 000377626300001 |
| Title Alternative | Drug interaction (35. Opioid-analgesic drug interactions) |
|---|---|
| FullText URL | 128_53.pdf |
| Author | Sada, Hikaru| Kajizono, Makoto| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2016-04-01 |
| Volume | volume128 |
| Issue | issue1 |
| Start Page | 53 |
| End Page | 59 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.53 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.53 |
| NAID | 130005149610 |
| Title Alternative | Behçetʼs disease complicated by ileocecal and esophageal perforation |
|---|---|
| FullText URL | 128_27.pdf |
| Author | Tsukumo, Yuta| Kawamoto, Kazuyuki| Takagi, Kosei| Chin, Kai| Matsuba, Yuri| Nagahisa, Yoshio| Okabe, Michio| Shirakawa, Yasuhiro| Itoh, Tadashi| Fujiwara, Toshiyoshi| |
| Abstract | A 36-year-old Japanese man known to have incomplete Behçet’s disease (oral aphthous ulcers, genital ulcers, skin lesions, and esophageal and ileocecal ulcers) was admitted to our hospital in January 2011 for abdominal pain. We administered corticosteroids and immunosuppressants. Two months later, we performed an ileocecal resection to control gastrointestinal bleeding from the ileocecal ulcers. High fever persisted after this surgery, and upper gastrointestinal endoscopy demonstrated ulcer penetration between the lower and abdominal esophagus. Eighteen days after the initial ileocecal resection, we performed a lower esophagus resection, gastric tube reconstruction and enterostomy, during which we confirmed a 5-mm-dia. perforated site at the posterior wall of the abdominal esophagus. Postoperative anastomotic leakage and empyema occurred, but they were relieved by thoracic drainage and empyema dissection. |
| Keywords | ベーチェット病（Behçet’s disease） 食道（esophagus） 回盲部（ileocecal） 穿孔（perforation） 手術（surgery） |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2016-04-01 |
| Volume | volume128 |
| Issue | issue1 |
| Start Page | 27 |
| End Page | 32 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.27 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.27 |
| NAID | 130005149603 |
| Title Alternative | A case of mucinous adenocarcinoma of the duodenum and literature review of 16 cases reported in Japan |
|---|---|
| FullText URL | 128_21.pdf |
| Author | Hamano, Ikumi| Matsumoto, Yusuke| Endo, Yoshikatsu| Watanabe, Naoki| Kai, Kyouhei| Sato, Shizou| Wani, Yoji| |
| Abstract | Primary mucinous adenocarcinoma of the duodenum is rare. Here we report a case we recently encountered, and we review 16 cases reported in Japan. An 82-year-old Japanese woman was admitted to our hospital complaining of abdominal pain and heartburn. An endoscopic examination revealed a Type 2 tumor in the descending limb of the duodenum, and endoscopically obtained specimens revealed a poorly differentiated adenocarcinoma. We performed a curative pancreatoduodenectomy with lymph node resection, and the surgical specimen revealed that the duodenum was the primary site of the mucinous adenocarcinoma. The patient is currently alive ＞ 1 year after the operation without any evidence of recurrence. Of the 16 patients reviewed, all patients had advanced tumors those depth were T3-T4. 9 patients had lymph node metastasis and 4 patients had peritoneal dissemination at the time of surgery. Since mucinous adenocarcinoma of the duodenum is often progressive cancer at a diagnosis, which is tend to have a worse prognosis than other histological types. |
| Keywords | 原発性十二指腸癌（primary duodenal cancer） 粘液癌（mucinous carcinoma） 膵頭十二指腸切除（pancreatoduodenectomy） |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2016-04-01 |
| Volume | volume128 |
| Issue | issue1 |
| Start Page | 21 |
| End Page | 25 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.21 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.21 |
| NAID | 130005149602 |
| Title Alternative | Current state of and views regarding clinical approarches to Helicobacter pylori infection |
|---|---|
| FullText URL | 128_13.pdf |
| Author | Okada, Hiroyuki| |
| Keywords | Helicobacter pylori 除菌療法 胃癌 胃炎 MALT リンパ腫 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2016-04-01 |
| Volume | volume128 |
| Issue | issue1 |
| Start Page | 13 |
| End Page | 19 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.13 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.13 |
| NAID | 130005149601 |
| FullText URL | K0005254_abstract_review.pdf K0005254_fulltext.pdf |
|---|---|
| Author | Masaoka, Yoshihisa| |
| Published Date | 2015-12-31 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5254号 |
| Granted Date | 2015-12-31 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/CTED/54025 |
|---|---|
| Title Alternative | Study on the Factors for Development of Scientific Thinking in Science Education |
| FullText URL | cted_006_097_105.pdf |
| Author | Kaneta, Shinya| Kawasaki, Kousaku| Inada, Yoshihiko| |
| Abstract | これからの時代に必要とされる「科学的思考力」を育成するために，先行研究を分析することで科学的思考力を構成する6つの要素を抽出した。これらの要素の中で，現状の学校教育で育成が不十分な要素を教員養成学部の学生の予備的調査から抽出した結果，特に，批判的思考力の育成が十分でないことが明らかになった。初等中等教育の理科で科学的思考力を育成することを目指して，批判的思考力の育成に有効だと期待される仕掛けについて考察し，提案する。批判的思考力の情意面に存在する，児童・生徒が持つ心理的障壁を低くする仕掛けが重要な役割を果たすと考えられる。建設的な批判的思考力がもたらす価値や利益を児童・生徒が実感するプロセスが大切だと思われる。 |
| Keywords | 科学的リテラシー 理科 批判的思考 科学的思考力 初等中等教育 |
| Publication Title | 岡山大学教師教育開発センター紀要 |
| Published Date | 2016-03-04 |
| Volume | volume6 |
| Start Page | 97 |
| End Page | 105 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2016 岡山大学教師教育開発センター |
| File Version | publisher |
| NAID | 120005723293 |
| Author | Taniguchi, Masanari| Fukunaka, Ayako| Hagihara, Mitsue| Watanabe, Keiko| Kamino, Shinichiro| Kambe, Taiho| Enomoto, Shuichi| Hiromura, Makoto| |
|---|---|
| Published Date | 2013-03-07 |
| Publication Title | PLOS ONE |
| Volume | volume8 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/54008 |
|---|---|
| FullText URL | 70_1_67.pdf |
| Author | Senoo, Miki| Nakatsuka, Mikiya| |
| Abstract | Pregnant women with uterine leiomyomas may experience anxiety toward their pregnancies and unfavorable feelings toward their infants. From March to July 2010, we distributed anonymous self-recorded questionnaires to 200 pregnant women who visited Okayama Central Hospital for an antenatal check-up after informed consent was provided, and 132 women (23 pregnant women with uterine leiomyomas) were included in our study. Among the multiparous women in their first trimester, the women with uterine leiomyomas had a higher rate of anxiety than those without uterine leiomyomas. ʻAvoidanceʼ scores on the Feeling Toward the Baby Scale were significantly higher in the leiomyoma group. The conflict index scores tended to be higher in the leiomyoma group. A multivariate analysis revealed no factors associated with trait-anxiety scores, whereas high state-anxiety scores were correlated with low age;however, there was no correlation between these scores and uterine leiomyomas. Although no factors were associated with State-Trait Anxiety Inventory (STAI) and approach scores toward the baby, avoidance and conflict index scores were associated with the existence of uterine leiomyomas. In pregnant women with uterine leiomyomas, efforts should be made to reduce anxiety in the first trimester, and support should be provided to help these women develop positive feelings toward their babies. |
| Keywords | pregnancy uterine leiomyomas anxiety feelings toward the baby pregnancy loss |
| Amo Type | Erratum |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 67 |
| End Page | 68 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899613 |
| Related Url | http://doi.org/10.18926/AMO/53908 |
| JaLCDOI | 10.18926/AMO/54003 |
|---|---|
| FullText URL | 70_1_45.pdf |
| Author | Maruyama, Hidehiko| Nakata, Yusei| Kanazawa, Akane| Kikkawa, Kiyoshi| |
| Abstract | Mothers of preterm infants may find it difficult to express breast milk. There is a low breast milk rate among preterm infants at discharge at our hospital, and here we tested the hypothesis that milk expression factors were the cause of the low rate. The study subjects were born before 33 gestational weeks at our hospital between March 2005 and June 2014. Nutritional evaluation was performed at discharge and noted whether breast milk, infant formula, or a mix of the 2 was being given. We compared the group given breast milk or the mix versus the group given formula. Of the 337 infants, 40 cases were excluded. Data from 297 infants were analyzed. The mean (SD) gestational age and birth weight were 29.5 (2.4) weeks and 1,230 (391) g, respectively. At discharge, 26 (8.8%), 102 (33.3%), and 174 (57.9%) infants were given breast milk, formula, and the mix, respectively. A multivariate logistic regression analysis showed that the first milk expression (h) was the risk factor for the formula group: adjusted odds ratio (95% confidence interval) 1.06 (1.02-1.09) and p=0.002. Delayed first milk expression could affect the low breast milk rate at discharge. Improvement of milk expression should be achieved to promote breastfeeding. |
| Keywords | breast milk breastfeeding formula milk expression preterm |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 45 |
| End Page | 49 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899609 |
| Web of Science KeyUT | 000371288700006 |
| JaLCDOI | 10.18926/AMO/53999 |
|---|---|
| FullText URL | 70_1_13.pdf |
| Author | Arum Tri Wahyuningsih| Shen, Lianhua| Kobayashi, Kazuko| Sasaki, Takanori| Takenaka, Fumiaki| Hanada, Takahisa| Akehi, Masaru| Akahoshi, Akiya| Ozeki, Eiichi| Ando, Eiji| Matsuura, Eiji| |
| Abstract | Intact β2-glycoprotein I (iβ2GPI) is a glycoprotein that regulates coagulation and fibrinolysis. Nicked β2GPI (nβ2GPI) possesses an angiogenic property at a relatively low concentration, and an antiangiogenic property at a high concentration. Here we investigated the functions of βi 2GPI and nβ2GPI in vascular endothelial growth factor (VEGF)-A-induced endothelial cell proliferation and tube formation. We used noninvasive PET imaging to analyze the in vivo distribution of intravenously injected β2GPI variants in tumor lesions in mice. iβ2GPI was incubated with plasmin to obtain nβ2GPI, and its N-terminal sequence was analyzed. nβ2GPI had at least one other cleavage site upstream of the β2GPIʼs domain V, whereas the former plasmin-cleavage site locates between K317 and T318. Both of intact and nicked β2GPI significantly inhibited the VEGF-A-induced cell proliferation and the tube formation of human umbilical vein endothelial cells (HUVECs). PET imaging visualized considerably distributed intensities of all tested β2GPI variants in tumor lesions of pancreatic tumor cell-xenografts. These results indicate that β2GPI may be physiologically and pathophysiologically important in the regulation of not only coagulation and fibrinolysis, but also angiogenesis. |
| Keywords | β2-glycoprotein I (β2GPI) angiogenesis vascular endothelial growth factor-A (VEGF-A) positron emission tomography (PET) imaging |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 13 |
| End Page | 24 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899605 |
| Web of Science KeyUT | 000371288700002 |
| Author | Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-01-22 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Nakatsuka, Atsuko| Matsuyama, Makoto| Yamaguchi, Satoshi| Katayama, Akihiro| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Ogawa, Daisuke| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Watanabe, Eijiro| Wada, Jun| |
|---|---|
| Published Date | 2016-02-17 |
| Publication Title | Scientific Reports |
| Volume | volume6 |
| Content Type | Journal Article |
| Author | Subramanian, Venkateswaran| Moorleghen, Jessica J.| Balakrishnan, Anju| Howatt, Deborah A.| Chishti, Athar H.| Uchida, Haruhito A.| |
|---|---|
| Published Date | 2013-08-19 |
| Publication Title | PLOS ONE |
| Volume | volume8 |
| Issue | issue8 |
| Content Type | Journal Article |
| Author | 吉田 裕一| 後藤 丹十郎| 安場 健一郎| 田中 義行| |
|---|---|
| Published Date | 2015-04-01 |
| Publication Title | 岡山大学農学部センター報告 |
| Volume | volume37 |
| Content Type | Departmental Bulletin Paper |
| Author | 吉田 裕一| 宮地 大介| 後藤 丹十郎| 田中 義行| 安場 健一郎| 本村 翔| |
|---|---|
| Published Date | 2015-04-01 |
| Publication Title | 岡山大学農学部センター報告 |
| Volume | volume37 |
| Content Type | Departmental Bulletin Paper |
| Author | 齊藤 邦行| |
|---|---|
| Published Date | 2015-04-01 |
| Publication Title | 岡山大学農学部センター報告 |
| Volume | volume37 |
| Content Type | Others |
| Author | Yoshii, Taishi| Hermann-Luibl, Christiane| Kistenpfennig, Christa| Schmid, Benjamin| Tomioka, Kenji| Helfrich-Förster, Charlotte| |
|---|---|
| Published Date | 2015-04-15 |
| Publication Title | The Journal of neuroscience |
| Volume | volume35 |
| Issue | issue15 |
| Content Type | Journal Article |
