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Author Okada, Tomoaki| Miyoshi, Toru| Doi, Masayuki| Seiyama, Kosuke| Takagi, Wataru| Sogo, Masahiro| Nosaka, Kazumasa| Takahashi, Masahiko| Okawa, Keisuke| Ito, Hiroshi|
Keywords atherosclerotic cardiovascular disease polyunsaturated fatty acids eicosapentaenoic acid docosahexaenoic acid arachidonic acid descriptive study
Published Date 2021-01-17
Publication Title Nutrients
Volume volume13
Issue issue1
Publisher MDPI
Start Page 253
ISSN 2072-6643
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 33477264
DOI 10.3390/nu13010253
Web of Science KeyUT 000610647500001
Related Url isVersionOf https://doi.org/10.3390/nu13010253
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Author Noda, Hiroshi| Kimura, Shuhei| Hosokawa Morizane, Mio| Shiode, Yusuke| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Kanzaki, Yuki| Fujiwara, Atsushi| Morizane, Yuki|
Published Date 2020-12-09
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature Research
Start Page 21497
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 33299123
DOI 10.1038/s41598-020-78693-5
Web of Science KeyUT 000608953600006
Related Url isVersionOf https://doi.org/10.1038/s41598-020-78693-5
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Author Sugihara, Yuusaku| Hiraoka, Sakiko| Yasutomi, Eriko| Oka, Shohei| Yamasaki, Yasushi| Inokuchi, Toshihiro| Kinugasa, Hideaki| Takahara, Masahiro| Morito, Yuki| Takahashi, Sakuma| Harada, Keita| Tanaka, Takehiro| Otsuka, Fumio| Okada, Hiroyuki|
Keywords graft-vs.-host disease terminal ileum allo-hematopoietic stem cell transplantation villous atrophy endoscopy
Published Date 2020-02-21
Publication Title Experimental and Therapeutic Medicine
Volume volume19
Issue issue4
Publisher Spandidos Publications
Start Page 3076
End Page 3080
ISSN 1792-0981
NCID AA12610820
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Sugiharaet al.
File Version publisher
PubMed ID 32256795
DOI 10.3892/etm.2020.8538
Web of Science KeyUT 000523637100082
Related Url isVersionOf https://doi.org/10.3892/etm.2020.8538
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Author Nishioka, Keiji| Kato, Yusuke| Ozawa, Shin-ichiro| Takahashi, Yuichiro| Sakamoto, Wataru|
Keywords Chloroplast Phos-tag Protein phosphorylation Thylakoid membrane STN7 STN8
Published Date 2021-01
Publication Title Photosynthesis Research
Volume volume147
Issue issue1
Publisher Springer
Start Page 107
End Page 124
ISSN 0166-8595
NCID AA00362200
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Authors.
File Version publisher
PubMed ID 33269435
DOI 10.1007/s11120-020-00803-1
Web of Science KeyUT 000595363200001
Related Url isVersionOf https://doi.org/10.1007/s11120-020-00803-1
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Author Hamada, Kenta| Kanzaki, Hiromitsu| Inoue, Masafumi| Ishiyama , Shuhei| Yamauchi, Kenji| Miyahara, Koji| Toyokawa, Tatsuya| Tsuzuki, Takao| Miyaike, Jiro| Matsubara, Minoru| Takahashi, Sakuma| Nishimura, Mamoru| Takenaka, Ryuta| Yunoki, Naoko| Hori, Shinichiro| Kobayashi, Sayo| Yamasaki, Yasushi| Kawahara, Yoshiro| Ishikawa, Hideki| Okada, Hiroyuki|
Keywords anticoagulant agent bleeding endoscopic submucosal dissection gastric cancer heparin replacement warfarin
Published Date 2020-11-01
Publication Title Internal Medicine
Volume volume59
Issue issue21
Publisher The Japanese Society of Internal Medicine
Start Page 2643
End Page 2651
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 32641658
DOI 10.2169/internalmedicine.4998-20
Web of Science KeyUT 000589268900003
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.4998-20
JaLCDOI 10.18926/AMO/61217
FullText URL 74_6_557.pdf
Author Ishiguro, Mikako| Takenaka, Ryuta| Ogura, Kenichiro| Hiratsuka, Akira| Takeda, Hiromasa| Kawai, Daisuke| Tsugeno, Hirofumi| Fujiki, Shigeatsu| Okada, Hiroyuki|
Abstract A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively.
Keywords 5-fluorouracil dihydropyrimidine dehydrogenase deficiency DPYD variant gastric cancer
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 557
End Page 562
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361878
Web of Science KeyUT 000601203600014
NAID 120006948944
JaLCDOI 10.18926/AMO/61215
FullText URL 74_6_545.pdf
Author Tatebe, Yasuhisa| Kanamitsu, Kiichiro| Kanzaki, Hirotaka| Ishida, Hisashi| Fujiwara, Kaori| Washio, Kana| Kitamura, Yoshihisa| Sendo, Toshiaki| Shimada, Akira| Tsukahara, Hirokazu|
Abstract Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. We present a case of a pediatric patient with acute lymphoblastic leukemia who suffered from persistently high plasma methotrexate concentrations and acute kidney injuries after the admin-istration of a medium dose of methotrexate. Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. This case highlights that polymorphisms of methotrexate transporter pathways can adversely affect methotrexate elimination in a clinically significant manner.
Keywords methotrexate polymorphism drug elimination acute kidney injury acute lymphoblastic leukemia
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 545
End Page 550
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361876
Web of Science KeyUT 000601203600012
NAID 120006948942
JaLCDOI 10.18926/AMO/61212
FullText URL 74_6_525.pdf
Author Aoki, Hideki| Utsumi, Masashi| Kimura, Yuji| Takahashi, Yosuke| Nagahisa, Seiichi| Nishimura, Seitaro| Une, Yuta| Watanabe, Megumi| Taniguchi, Fumitaka| Arata, Takashi| Katsuda, Koh| Tanakaya, Kohji|
Abstract Cardiac metastasis originating from hepatocellular carcinoma (HCC) is a rare condition with a poor prognosis. No therapeutic standards for cardiac metastasis originating from HCC have been established. At 19 months after a curative hepatectomy, a 64-year-old Japanese hepatitis B virus-positive male patient experienced solitary cardiac metastasis originating from HCC. The cardiac tumor was discovered in the right ventricle. The patient received three courses of radiotherapy and chemotherapy and survived > 3 years after the initial diagnosis of cardiac metastasis. His case demonstrates that radiotherapy combined with chemotherapy can be an effective treatment for cardiac metastasis.
Keywords hepatocellular carcinoma cardiac metastasis radiotherapy chemotherapy
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 525
End Page 530
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361873
Web of Science KeyUT 000601203600009
NAID 120006948951
JaLCDOI 10.18926/AMO/61211
FullText URL 74_6_521.pdf
Author Itazaki, Yujiro| Tsujimoto, Hironori| Sugasawa, Hidekazu| Yaguchi, Yoshihisa| Nomura, Shinsuke| Ito, Nozomi| Harada, Manabu| Sugihara, Takao| Tsuchiya, Satoshi| Ishibashi, Yusuke| Kouzu, Keita| Kishi, Yoji| Ueno, Hideki |
Abstract We report a successful dissection of metastatic posterior thoracic para-aortic lymph node (No. 112aoP) via bilateral thoracoscopic surgery. With the anesthetized patient (a 73-year-old Japanese woman) in the prone position, two working ports were inserted for the left-side approach, and artificial pneumothorax was created. Thoracoscopic examination revealed a swollen LN posterior to the descending aorta. Fat and metastatic LNs posterior to the aorta were dissected from the aortic arch level to the diaphragm while preserving intercostal arteries. For the right-side approach, two working ports were inserted and a routine thoracoscopic esophagec-tomy was performed. Gastric conduit reconstruction was achieved laparoscopically. Operation time for the left thoracic procedure: 54 min; estimated blood loss: almost none. No recurrence was detected 24 months post-operatively. There are several surgical options for approaching No. 112aoP, including transhiatal, left thora-cotomy, and thoracoscopy. Although a wide dissection of the posterior thoracic para-aortic area has not been reported, it may be feasible and safe if the artery of Adamkiewicz and intercostal arteries are preserved. A min-imally invasive bilateral thoracoscopic approach for a thoracoscopic esophagectomy is safe and useful for esophageal cancer patients with solitary No. 112aoP metastasis.
Keywords bilateral approach posterior thoracic para-aortic lymph node thoracoscopic esophagectomy
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 521
End Page 524
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361872
Web of Science KeyUT 000601203600008
NAID 120006948950
JaLCDOI 10.18926/AMO/61204
FullText URL 74_6_461.pdf
Author Kono, Yoshiyasu| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
Abstract Gastric cancer usually arises in middle-aged to older patients, and is rarely found in younger patients. The clin-ical characteristics, etiology, prognosis, preventive methods and treatment of gastric cancer in young patients have not been fully investigated because of its low prevalence. In this review, we discuss the current under-standing and clinical problems associated with gastric cancer in young patients. Helicobacter pylori (H. pylori), which is a major cause of gastric cancer, especially in older populations, is closely associated with gastric cancer in young patients as well as in older patients. Gastric cancer in young patients tends to be diagnosed at an advanced stage with alarm symptoms. However, young patients with advanced gastric cancer tend to have a favorable general condition and organ function, so they can tolerate intensive systematic chemotherapy. Unfortunately, the prognosis of gastric cancer in young patients with an advanced stage is not favorable. We should not take this rare disease lightly, given its poor prognosis if patients are diagnosed at an unresectable stage. The evaluation of the H. pylori infection status and performance of H. pylori eradication therapy to prevent gastric cancer in young patients as well as the development of more intensive chemotherapy regimens for unre-sectable gastric cancer in young patients are warranted.
Keywords gastric cancer young patients Helicobacter pylori
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 461
End Page 466
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361865
Web of Science KeyUT 000601203600001
NAID 120006948954
FullText URL fultext.pdf Fig 1.tif Fig 2.tif Fig 3.tif Fig 4.tif Suppl Fig.tif
Author Yamamoto, Haruchika| Yamamoto, Hiromasa| Soh, Junichi| Suzuki, Etsuji| Namba, Kei| Suzawa, Ken| Miyoshi, Kentaroh| Otani, Shinji| Okazaki, Mikio| Sugimoto, Seiichiro| Yamane, Masaomi| Yorifuji, Takashi| Takahashi, Katsuhito| Toyooka, Shinichi|
Note This is a post-peer-review, pre-copyedit version of an article published in Annals of Surgical Oncology. The final authenticated version is available online at: http://dx.doi.org/10.1245/s10434-020-09272-1.|
Published Date 2020-11-24
Publication Title Annals of Surgical Oncology
Volume volume28
Publisher Springer
Start Page 3884
End Page 3890
ISSN 1068-9265
NCID AA11016573
Content Type Journal Article
language English
File Version author
PubMed ID 33236252
DOI 10.1245/s10434-020-09272-1
Web of Science KeyUT 000592170800006
Related Url isVersionOf https://doi.org/10.1245/s10434-020-09272-1
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Author Tsurutani, Junji| Hara, Fumikata| Kitada, Masahiro| Takahashi, Masato| Kikawa, Yuichiro| Kato, Hiroaki| Sakata, Eiko| Naito, Yoichi| Hasegawa, Yoshie| Saito, Tsuyoshi| Iwasa, Tsutomu| Taira, Naruto| Takashima, Tsutomu| Kashiwabara, Kosuke| Aihara, Tomohiko| Mukai, Hirofumi|
Keywords Nab-paclitaxel Nanoparticle albumin–bound paclitaxel Metastatic breast cancer Solvent-base paclitaxel Chemotherapy-induced peripheral neuropathy
Published Date 2020-12-09
Publication Title The Breast
Volume volume55
Publisher Elsevier
Start Page 63
End Page 68
ISSN 0960-9776
NCID AA10844161
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
DOI 10.1016/j.breast.2020.12.002
Related Url isVersionOf https://doi.org/10.1016/j.breast.2020.12.002
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Author Morimoto, Nobutoshi| Morimoto, Mizuki| Takahashi, Yoshiaki| Takamiya, Motonori| Nishino, Ichizo| Abe, Koji|
Keywords Facioscapulohumeral muscular dystrophy (FSHD) Restrictive ventilatory defect (RVD) Congestive heart failure (CHF)
Published Date 2020-12
Publication Title eNeurologicalSci
Volume volume21
Publisher Elsevier
Start Page 100284
ISSN 2405-6502
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 33195829
DOI 10.1016/j.ensci.2020.100284
Related Url isVersionOf https://doi.org/10.1016/j.ensci.2020.100284
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Author Iwamuro, Masaya| Takahashi, Takahide| Watanabe, Natsuki| Omote, Sizuma| Matsueda, Katsunori| Tanaka, Takehiro| Ennishi, Daisuke| Otsuka, Fumio| Yoshino, Tadashi| Okada, Hiroyuki|
Keywords Flow cytometry Light chain restriction Gastrointestinal lymphoma Lymphocyte isolation
Published Date 2020
Publication Title MethodsX
Volume volume7
Publisher Elsevier
Start Page 101095
ISSN 2215-0161
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 33102158
DOI 10.1016/j.mex.2020.101095
Web of Science KeyUT 000607658800035
Related Url isVersionOf https://doi.org/10.1016/j.mex.2020.101095
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Author Ueno, Hiroshi| Shimada, Atsumi| Suemitsu, Shunsuke| Murakami, Shinji| Kitamura, Naoya| Wani, Kenta| Takahashi, Yu| Matsumoto, Yosuke| Okamoto, Motoi| Ishihara, Takeshi|
Keywords Epilepsy Kindling Pentylenetetrazol Perineuronal nets Wisteria floribunda
Published Date 2020
Publication Title IBRO Reports
Volume volume9
Publisher Elsevier
Start Page 102
End Page 114
ISSN 2451-8301
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32760846
DOI 10.1016/j.ibror.2020.07.007
Related Url isVersionOf https://doi.org/10.1016/j.ibror.2020.07.007
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Author Takahashi, Kosuke| Kimura, Shuhei| Hosokawa, Mio Morizane| Shiode, Yusuke| Doi, Shinichiro| Matoba, Ryo| Kanzaki, Yuki| Yonekawa, Yoshihiro| Morizane, Yuki|
Keywords Case report Perfluorocarbon Retinal detachment Subretinal injection Vitreoretinal surgery
Published Date 2020-10-23
Publication Title BMC Ophthalmology
Volume volume20
Issue issue1
Publisher BMC
Start Page 427
ISSN 1471-2415
NCID AA12035369
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 33097007
DOI 10.1186/s12886-020-01698-1
Web of Science KeyUT 000586445100002
Related Url isVersionOf https://doi.org/10.1186/s12886-020-01698-1
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Author Iwamuro, Masaya| Takahashi, Takahide| Tanaka, Takehiro| Toji, Tomohiro| Hiraoka, Sakiko| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
Published Date 2020-10-07
Publication Title Case Reports in Gastrointestinal Medicine
Volume volume2020
Publisher Hindawi
Start Page 8893604
ISSN 2090-6528
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Masaya Iwamuro et al.
File Version publisher
PubMed ID 33083067
DOI 10.1155/2020/8893604
Web of Science KeyUT 000583201400001
Related Url isVersionOf https://doi.org/10.1155/2020/8893604
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Author Satouchi, Miyako| Nosaki, Kaname| Takahashi, Toshiaki| Nakagawa, Kazuhiko| Aoe, Keisuke| Kurata, Takayasu| Sekine, Akimasa| Horiike, Atsushi| Fukuhara, Tatsuro| Sugawara, Shunichi| Umemura, Shigeki| Saka, Hideo| Okamoto, Isamu| Yamamoto, Nobuyuki| Sakai, Hiroshi| Kishi, Kazuma| Katakami, Nobuyuki| Horinouchi, Hidehito| Hida, Toyoaki| Okamoto, Hiroaki| Atagi, Shinji| Ohira, Tatsuo| Han, Shi Rong| Noguchi, Kazuo| Ebiana, Victoria| Hotta, Katsuyuki|
Keywords Japan non-small-cell lung carcinoma PD-L1 protein pembrolizumab treatment outcome
Published Date 2020-09-14
Publication Title Cancer Science
Volume volume111
Issue issue12
Publisher Wiley
Start Page 4480
End Page 4489
ISSN 1347-9032
NCID AA11808050
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 32926507
DOI 10.1111/cas.14647
Web of Science KeyUT 000577975700001
Related Url isVersionOf https://doi.org/10.1111/cas.14647
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Author Paul, Subha Sankar| Takahashi, Eizo| Chowdhury, Goutam| Miyoshi, Shin-ichi| Mizuno, Tamaki| Mukhopadhyay, Asish K.| Dutta, Shanta| Okamoto, Keinosuke|
Keywords Vibrio cholerae cholera toxin aquatic solution viability
Published Date 2020-08
Publication Title Biological and Pharmaceutical Bulletin
Volume volume43
Issue issue8
Publisher Pharmaceutical Society of Japan
Start Page 1288
End Page 1291
ISSN 0918-6158
NCID AA10885497
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Pharmaceutical Society of Japan
File Version publisher
PubMed ID 32522950
DOI 10.1248/bpb.b20-00350
NAID 130007883887
Web of Science KeyUT 000567184000022
Related Url isVersionOf https://doi.org/10.1248/bpb.b20-00350
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Author Matsuoka-Uchiyama, Natsumi| Tsuji, Kenji| Fukushima, Kazuhiko| Kitamura, Shinji| Uchida, Haruhito A.| Sugiyama, Hitoshi| Takahashi, Naoki| Iwano, Masayuki| Wada, Jun|
Published Date 2020-06-18
Publication Title Kidney International Reports
Volume volume5
Issue issue9
Publisher Elsevier
Start Page 1576
End Page 1580
ISSN 24680249
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 International Society of Nephrology
File Version publisher
PubMed ID 32954083
DOI 10.1016/j.ekir.2020.06.010
Related Url isVersionOf https://doi.org/10.1016/j.ekir.2020.06.010