result 47942 件
| FullText URL | fulltext20220630-11.pdf Tables20220630-11.pdf SI20220630-11.pdf |
|---|---|
| Author | Uchida, Tetsuya| Nishioka, Ryohei| Yanai, Risa| |
| Keywords | cellulose nanocrystals composite dispersibility mechanical properties surface treatment |
| Note | This is the peer reviewed version of the following article: [Uchida, T, Nishioka, R, Yanai, R. Preparation of cellulose nanocrystals coated with polymer crystals and their application in composite films. Polym Adv Technol. 2022; 1- 8.], which has been published in final form at [https://doi.org/10.1002/pat.5705]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. This fulltext is available in April 2023.| |
| Published Date | 2022-04-26 |
| Publication Title | Polymers for Advanced Technologies |
| Volume | volume33 |
| Issue | issue8 |
| Publisher | Wiley |
| Start Page | 2511 |
| End Page | 2518 |
| ISSN | 1042-7147 |
| NCID | AA10838191 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 John Wiley & Sons Ltd. |
| File Version | author |
| DOI | 10.1002/pat.5705 |
| Web of Science KeyUT | 000787505800001 |
| Related Url | isVersionOf https://doi.org/10.1002/pat.5705 |
| FullText URL | fulltext20220630-10.pdf |
|---|---|
| Author | Sumi, Nanako| Nagahiro, Shota| Nakata, Eiji| Watanabe, Kazunori| Ohtsuki, Takashi| |
| Keywords | Ultrasound Sonosensitizer Rose Bengal RNAi RNA delivery |
| Note | © 2022 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/.
This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.bmcl.2022.128767. This fulltext is available in May 2024. | |
| Published Date | 2022-07 |
| Publication Title | Bioorganic & Medicinal Chemistry Letters |
| Volume | volume68 |
| Publisher | Elsevier BV |
| Start Page | 128767 |
| ISSN | 0960-894X |
| NCID | AA1079577X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Elsevier Ltd. |
| File Version | author |
| PubMed ID | 35513220 |
| DOI | 10.1016/j.bmcl.2022.128767 |
| Web of Science KeyUT | 000800009100005 |
| Related Url | isVersionOf https://doi.org/10.1016/j.bmcl.2022.128767 |
| FullText URL | fulltext20220630-9.pdf |
|---|---|
| Author | Naito, Hiromichi| Nojima, Tsuyoshi| Yorifuji, Takashi| Fujisaki, Noritomo| Nakao, Atsunori| |
| Keywords | Post cardiac arrest syndrome Hypoxic ischemic brain injury Cardiopulmonary resuscitation Prognosis |
| Published Date | 2022-8 |
| Publication Title | The American Journal of Emergency Medicine |
| Volume | volume58 |
| Publisher | Elsevier BV |
| Start Page | 27 |
| End Page | 32 |
| ISSN | 0735-6757 |
| NCID | AA10642870 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 35623180 |
| DOI | 10.1016/j.ajem.2022.05.017 |
| Web of Science KeyUT | 000808614800006 |
| FullText URL | fulltext20220630-8.pdf |
|---|---|
| Author | Nishimura, Takeshi| Nojima, Tsuyoshi| Naito, Hiromichi| Ishihara, Satoshi| Nakayama, Shinichi| Nakao, Atsunori| |
| Keywords | JTDB Prehospital Emergency life-saving technician Trauma |
| Published Date | 2022-06 |
| Publication Title | The American Journal of Emergency Medicine |
| Volume | volume56 |
| Publisher | Elsevier BV |
| Start Page | 218 |
| End Page | 222 |
| ISSN | 0735-6757 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 35447563 |
| DOI | 10.1016/j.ajem.2022.04.004 |
| Web of Science KeyUT | 000799775900035 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ajem.2022.04.004 |
| FullText URL | fulltext20220630-1.pdf |
|---|---|
| Author | Udono, Heiichiro| Nishida, Mikako| |
| Keywords | Mitochondrial ROS Oxidative stress Apoptosis Ageing Nrf2 |
| Note | © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/.
This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.bbagen.2022.130171] . This fulltext is available in Aug. 2023.| |
| Published Date | 2022-08 |
| Publication Title | Biochimica et Biophysica Acta (BBA) - General Subjects |
| Volume | volume1866 |
| Issue | issue8 |
| Publisher | Elsevier BV |
| Start Page | 130171 |
| ISSN | 0304-4165 |
| NCID | AA00564679 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Elsevier B.V. |
| File Version | author |
| PubMed ID | 35588955 |
| DOI | 10.1016/j.bbagen.2022.130171 |
| Web of Science KeyUT | 000806942900004 |
| Related Url | isVersionOf https://doi.org/10.1016/j.bbagen.2022.130171 |
| FullText URL | fulltext20220630-7.pdf figure20220630-7.pdf |
|---|---|
| Author | Nagasaki, Joji| Togashi, Yosuke| |
| Keywords | CD4(+) T cell cytotoxic CD4(+ )T cell regulatory T cell T-cell exhaustion |
| Note | This is a pre-copyedited, author-produced version of an article accepted for publication in [International Immunology] following peer review. The version of record [Joji Nagasaki, Yosuke Togashi, A variety of ‘exhausted’ T cells in the tumor microenvironment, International Immunology, Volume 34, Issue 11, November 2022, Pages 563–570, https://doi.org/10.1093/intimm/dxac013] is available online at: [https://doi.org/10.1093/intimm/dxac013] This fulltext is available in April 2023.| |
| Published Date | 2022-4-23 |
| Publication Title | International Immunology |
| Volume | volume34 |
| Issue | issue11 |
| Publisher | Oxford University Press |
| Start Page | 563 |
| End Page | 570 |
| ISSN | 1460-2377 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | author |
| PubMed ID | 35460561 |
| DOI | 10.1093/intimm/dxac013 |
| Web of Science KeyUT | 000805278200001 |
| Related Url | isVersionOf https://doi.org/10.1093/intimm/dxac013 |
| FullText URL | fulltext20220630-6.pdf |
|---|---|
| Author | Tsunata, Ren| Takemoto, Masatsugu| Ogasawara, Satoshi| Saito, Tatsuya| Ueno, Tomoyuki| |
| Note | © 2022 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. | |
| Published Date | 2022-5 |
| Publication Title | IEEE Transactions on Industry Applications |
| Volume | volume58 |
| Issue | issue3 |
| Publisher | Institute of Electrical and Electronics Engineers (IEEE) |
| Start Page | 3470 |
| End Page | 3485 |
| ISSN | 0093-9994 |
| NCID | AA00667900 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright © 2022, IEEE |
| File Version | author |
| DOI | 10.1109/tia.2022.3154336 |
| Web of Science KeyUT | 000799279300052 |
| Related Url | isVersionOf https://doi.org/10.1109/tia.2022.3154336 |
| FullText URL | fulltext20220630-5.pdf figure20220630-5.pdf |
|---|---|
| Author | Okazaki, Yuki| Furumatsu, Takayuki| Kodama, Yuya| Hiranaka, Takaaki| Kintaka, Keisuke| Kamatsuki, Yusuke| Ozaki, Toshifumi| |
| Keywords | Anterior cruciate ligament Coronal inclination Knee kinematics Magnetic resonance imaging Medial meniscus Posterior root tear |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00590-022-03285-0 This fulltext is available in May 2023.| |
| Published Date | 2022-05-20 |
| Publication Title | European Journal of Orthopaedic Surgery and Traumatology |
| Volume | volume33 |
| Issue | issue4 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1255 |
| End Page | 1262 |
| ISSN | 1432-1068 |
| NCID | AA11622799 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature 2022 |
| File Version | author |
| PubMed ID | 35593940 |
| DOI | 10.1007/s00590-022-03285-0 |
| Web of Science KeyUT | 000800795900002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00590-022-03285-0 |
| FullText URL | fulltext20220630-4.pdf |
|---|---|
| Author | Kato, Kosaku| Uemura, Yohei| Asakura, Kiyotaka| Yamakata, Akira| |
| Note | This document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Physical Chemistry C, copyright © 2022 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jpcc.2c01662 This fulltext is available in May 2023.| |
| Published Date | 2022-05-25 |
| Publication Title | The Journal of Physical Chemistry C |
| Volume | volume126 |
| Issue | issue22 |
| Publisher | American Chemical Society |
| Start Page | 9257 |
| End Page | 9263 |
| ISSN | 1932-7447 |
| NCID | AA1217589X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 American Chemical Society |
| File Version | author |
| DOI | 10.1021/acs.jpcc.2c01662 |
| Web of Science KeyUT | 000810253900001 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.jpcc.2c01662 |
| FullText URL | fulltext20220630-3.pdf |
|---|---|
| Author | Maki, Yuta| Kawata, Kazuki| Liu, Yanbo| Goo, Kang‐Ying| Okamoto, Ryo| Kajihara, Yasuhiro| Satoh, Ayano| |
| Keywords | glycoprotein N-glycan cholera toxin native chemical ligation live imaging |
| Note | This is the peer reviewed version of the following article: [Y. Maki, K. Kawata, Y. Liu, K.-Y. Goo, R. Okamoto, Y. Kajihara, A. Satoh, Chem. Eur. J. 2022, 28, e202201253], which has been published in final form at [https://doi.org/10.1002/chem.202201253]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. This fulltext is available in May 2023.| |
| Published Date | 2022-05-23 |
| Publication Title | Chemistry - A European Journal |
| Volume | volume28 |
| Issue | issue37 |
| Publisher | Wiley |
| Start Page | e202201253 |
| ISSN | 0947-6539 |
| NCID | AA11076269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Wiley-VCH GmbH |
| File Version | author |
| PubMed ID | 35604098 |
| DOI | 10.1002/chem.202201253 |
| Web of Science KeyUT | 000798823300001 |
| Related Url | isVersionOf https://doi.org/10.1002/chem.202201253 |
| FullText URL | fulltext20220620-4.pdf |
|---|---|
| Author | Ren, Jianchao| Kaneta, Takashi| |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s44211-022-00078-7 This fulltext is available in Feb. 2023.| |
| Published Date | 2022-02-25 |
| Publication Title | Analytical Sciences |
| Volume | volume38 |
| Issue | issue4 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 651 |
| End Page | 655 |
| ISSN | 0910-6340 |
| NCID | AA10500785 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022. The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry. |
| File Version | author |
| PubMed ID | 35286641 |
| DOI | 10.1007/s44211-022-00078-7 |
| Web of Science KeyUT | 000808551700004 |
| Related Url | isVersionOf https://doi.org/10.1007/s44211-022-00078-7 |
| FullText URL | fulltext20220630-2.pdf |
|---|---|
| Author | Takahashi, Misa| Hagiya, Hideharu| Tanaka, Shuichi| Yamamoto, Koichiro| Honda, Hiroyuki| Hasegawa, Kou| Otsuka, Fumio| |
| Note | © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/.
This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jiac.2022.02.021] . This fulltext is available in March 2023.| |
| Published Date | 2022-7 |
| Publication Title | Journal of Infection and Chemotherapy |
| Volume | volume28 |
| Issue | issue7 |
| Publisher | Elsevier BV |
| Start Page | 978 |
| End Page | 981 |
| ISSN | 1341-321X |
| NCID | AA11057978 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Elsevier B.V. |
| File Version | author |
| PubMed ID | 35277342 |
| DOI | 10.1016/j.jiac.2022.02.021 |
| Web of Science KeyUT | 000808081000003 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jiac.2022.02.021 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tamura, Katsunori| Oshima, Yuri| Fuse, Yuta| Nagaoka, Noriyuki| Kunoh, Tatsuki| Nakanishi, Makoto| Fujii, Tatsuo| Nanba, Tokuro| Takada, Jun| |
| Published Date | 2022-04-10 |
| Publication Title | ACS Omega |
| Volume | volume7 |
| Issue | issue15 |
| Publisher | American Chemical Society |
| Start Page | 12795 |
| End Page | 12802 |
| ISSN | 2470-1343 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 35474768 |
| DOI | 10.1021/acsomega.1c07390 |
| Web of Science KeyUT | 000812569200001 |
| Related Url | isVersionOf https://doi.org/10.1021/acsomega.1c07390 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamada, Yuto| Fujiwara, Masaki| Shimazu, Taichi| Etoh, Tsuyoshi| Kodama, Masafumi| So, Ryuhei| Matsushita, Takanori| Yoshimura, Yusaku| Horii, Shigeo| Fujimori, Maiko| Takahashi, Hirokazu| Nakaya, Naoki| Miyaji, Tempei| Hinotsu, Shiro| Harada, Keita| Okada, Hiroyuki| Uchitomi, Yosuke| Yamada, Norihito| Inagaki, Masatoshi| |
| Published Date | 2022-06 |
| Publication Title | BMJ Open |
| Volume | volume12 |
| Issue | issue6 |
| Publisher | BMJ Publishing Group |
| Start Page | e060621 |
| ISSN | 2044-6055 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Author(s) (or their employer(s)) 2022. |
| File Version | publisher |
| PubMed ID | 35701062 |
| DOI | 10.1136/bmjopen-2021-060621 |
| Web of Science KeyUT | 000811702800009 |
| Related Url | isVersionOf https://doi.org/10.1136/bmjopen-2021-060621 |
| JaLCDOI | 10.18926/AMO/63722 |
|---|---|
| FullText URL | 76_3_281.pdf |
| Author | Yu, Bo| Wang, Rui| Luo, Huikun| Yang, Di| Wang, Simo| Yu, Yaqiong| Okamura, Hirohiko| Qiu, Lihong| |
| Abstract | Periodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of PDL cells’ inflammatory factors. Jmjd3 expression in periapical lesions was examined by immunostaining. Using siRNA specific for Jmjd3 or the specific Jmjd3 inhibitor GSK-J4, we determined Jmjd3’s roles in osteogenic differentiation and cytokine production by real-time RT-PCR. The locations of Jmjd3 and NF-κB were analyzed by immunocytochemistry. Compared to healthy PDLs, the periapical lesion samples showed higher Jmjd3 expression. Treatment with GSK-J4 or Jmjd3 siRNA suppressed PDL cells’ osteogenic differentiation by suppressing the expressions of bone-related genes (Runx2, Osterix, and osteocalcin) and mineralization. Jmjd3 knockdown decreased the expressions of cytokines (TNF-α, IL-1β, and IL-6) induced by lipopolysaccharide extracted from Porphyromonas endodontalis (Pe-LPS). Pe-LPS induced the nuclear translocations of Jmjd3 and NF-κB; the latter was inhibited by GSK-J4 treatment. Jmjd3 appears to regulate PDL cells’ osteogenic differentiation and proinflammatory cytokine expressions. |
| Keywords | periapical lesions histone demethylase Jmjd3 periodontal ligament cell osteogenic differentiation proinflammatory cytokines |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 281 |
| End Page | 290 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790358 |
| Web of Science KeyUT | 000823568300007 |
| JaLCDOI | 10.18926/AMO/63721 |
|---|---|
| FullText URL | 76_3_273.pdf |
| Author | Furuichi, Shuro| Mitani, Shigeru| Endo, Hirosuke| Namba, Yoshifumi| Kawamoto, Toyohiro| |
| Abstract | Following total hip arthroplasty (THA), some patients exhibit anterior or posterior pelvic tilt (PT). This case– control study investigated whether changes to PT following THA can be preoperatively predicted. Methods: 135 patients with hip osteoarthritis who underwent THA were assessed. The parameters measured preoperatively and one year postoperatively were lumbar lordosis (LL) based on plain X-ray and pelvic incidence (PI), PT, and sacral slope (SS), all of which were measured as pelvic morphological angles. Patients were classified into groups (A–E) based on the degree of post-THA PT, and their preoperative conditions were compared. PI minus LL was used to evaluate spinal alignment and pelvic balance. Results: Overall, 33%, 30%, 21%, 13%, and 3% of the hips of patients in Groups A, B, C, D, and E were postoperatively assessed. In Groups A–E, the SS values were 34.6°±8.9°, 37.6°±8.4°, 37.9°±8.9°, 42.6°±9.5°, and 60.0°±11.1°, whereas the PI minus LL values were 2.9°±15.0°, 1.2°±13.6°, 3.6°±17.7°, 12.7°±13.1°, and −1.3°±11.7°, respectively. Conclusions: Following THA, 70% of patients experienced posterior PT. Pre-THA SS ≥45° or PI minus LL ≥15° signified marked postoperative posterior tilt and could predict postoperative PT following THA. These findings are useful for implant placement, as they can predict pelvic inclination. |
| Keywords | hip total hip arthroplasty arthroplasty radiography lordosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 273 |
| End Page | 280 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790357 |
| Web of Science KeyUT | 000823568300006 |
| JaLCDOI | 10.18926/AMO/63720 |
|---|---|
| FullText URL | 76_3_265.pdf |
| Author | Kosaki, Yoshinori| Naito, Hiromichi| Iida, Atsuyoshi| Ihoriya, Hiromi| Nojima, Tsuyoshi| Yamada, Taihei| Yamamoto, Hirotsugu| Nakamura, Shunsuke| Mandai, Yasuhiro| Nakao, Atsunori| |
| Abstract | Basic life support (BLS) courses for laypersons, including cardiopulmonary resuscitation (CPR) training, is known to improve outcomes of out-of-hospital cardiac events. We asked medical students to provide BLS training for laypersons as a part of their emergency medicine education and evaluated the effects of training on the BLS skills of laypersons. We also used a questionnaire to determine whether the medical students who provided the BLS training were themselves more confident and motivated to perform BLS compared to students who did not provide BLS training. The proportions of laypersons who reported confidence in checking for a response, performing chest compressions, and automated external defibrillator (AED) use were significantly increased after the BLS training. The proportions of medical students who reported increased confidence/motivation in terms of understanding BLS, checking for a response, chest compression, use of AED, and willingness to perform BLS were significantly greater among medical students who provided BLS instructions compared to those who did not. BLS instruction by medical students was associated with an improvement in laypersons’ CPR accuracy and confidence in responding to cardiac arrest. The results indicate that medical students could gain understanding, confidence, and motivation in regard to their BLS skills by teaching BLS to laypersons. |
| Keywords | BLS medical education emergency medicine resuscitation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 265 |
| End Page | 271 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790356 |
| Web of Science KeyUT | 000823568300005 |
| JaLCDOI | 10.18926/AMO/63719 |
|---|---|
| FullText URL | 76_3_255.pdf |
| Author | Nakatsuka, Kosuke| Matsuoka, Yoshikazu| Kurita, Masako| Wang, Ruilin| Tsuboi, Chika| Sue, Nobutaka| Kaku, Ryuji| Morimatsu, Hiroshi| |
| Abstract | Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs. |
| Keywords | alpha adrenergic receptor glutamate transporter-1 mirror image pain neuropathic pain spared nerve injury |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 255 |
| End Page | 263 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790355 |
| Web of Science KeyUT | 000823568300004 |
| JaLCDOI | 10.18926/AMO/63718 |
|---|---|
| FullText URL | 76_3_247.pdf |
| Author | Yoshida, Shohei| Fujii, Nobuharu| Kamoi, Chihiro| Kitamura, Wataru| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Matsuoka, Ken-ichi| Maeda, Yoshinobu| |
| Abstract | Vaccine-preventable disease (VPD) infections are more severe in immunocompromised hosts. Vaccination against measles, mumps, rubella, and varicella zoster (VZV) (MMRV) is therefore recommended for hematopoietic stem cell transplantation (HCT) recipients. However, studies on adult HCT recipients with VPD infections are limited. At our institution, we have systematically conducted serological MMRV tests as a part of check-up examinations during long-term follow-up (LTFU) after HCT since 2015. This retrospective study aimed to evaluate changes in the serostatus between before and 2 years after allogeneic HCT. Among 161 patients, the pre-transplant seropositivity was 82.7% for measles, 86.8% for mumps, 84.2% for rubella, and 94.3% for VZV. Among 56 patients who underwent LTFU including serological MMRV tests at 2 years after HCT, the percentages maintaining seroprotective antibody levels for measles, mumps, rubella and VZV were 71.5% (40/56), 51.8% (29/56), 48.2% (27/56), and 60.7% (34/56), respectively. Vaccination was recommended for 22 patients, and 12 were vaccinated. Among the 12 vaccinated patients, rates of seroconversion were examined in 2-6 patients for each of the four viruses. They were 100% (3/3) for measles, 33.3% (1/3) for mumps, 50% (3/6) for rubella, and 0% (0/2) for VZV. Further studies are warranted to clarify the effect of vaccination in adult HCT recipients. |
| Keywords | vaccine-preventable disease vaccination allogeneic hematopoietic stem cell transplantation adult |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 247 |
| End Page | 253 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790354 |
| Web of Science KeyUT | 000823568300003 |
| JaLCDOI | 10.18926/AMO/63717 |
|---|---|
| FullText URL | 76_3_235.pdf |
| Author | Tenta, Masafumi| Eguchi, Jun| Wada, Jun| |
| Abstract | The combination of sarcopenia and obesity (sarcopenic obesity) is associated with the development of metabolic syndrome and cardiovascular events. The molecular pathways that develop sarcopenic obesity have studied intensively. Transmembrane protein 97 (TMEM97) is 176 amino acids conserved integral membrane protein with four transmembrane domains that is expressed in several types of cancer. Its physiological significance in adipose tissue and skeletal muscle has been unclear. We studied TMEM97-transgenic mice and mice lacking TMEM97, and our findings indicate that TMEM97 expression is regulated in adipose tissue and skeletal muscle from obesity. TMEM97 represses adipogenesis and promotes myogenesis in vitro. Fat-specific TMEM97 transgenic mice showed systemic insulin resistance. Mice overexpressing TMEM97 in skeletal muscle exhibited systemic insulin resistance. Mice lacking TMEM97 were protected against diet-induced obesity and insulin resistance. These phenotypes are associated with the effects of TMEM97 on inflammation genes in adipose tissue and skeletal muscle. Our findings indicates that there is a link between TMEM97 and chronic inflammation in obesity. |
| Keywords | adipose tissue skeletal muscle obesity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 235 |
| End Page | 245 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790353 |
| Web of Science KeyUT | 000823568300002 |
