result 9366 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Umeyama, Tomokazu| Mizutani, Daizu| Ikeda, Yuki| Osterloh, W. Ryan| Yamamoto, Futa| Kato, Kosaku| Yamakata, Akira| Higashi, Masahiro| Urakami, Takumi| Sato, Hirofumi| Imahori, Hiroshi| |
| Published Date | 2023-10-17 |
| Publication Title | Chemical Science |
| Volume | volume14 |
| Issue | issue42 |
| Publisher | Royal Society of Chemistry |
| Start Page | 11914 |
| End Page | 11923 |
| ISSN | 2041-6520 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Author(s). |
| File Version | publisher |
| PubMed ID | 37920360 |
| DOI | 10.1039/d3sc03604a |
| Web of Science KeyUT | 001087000200001 |
| Related Url | isVersionOf https://doi.org/10.1039/d3sc03604a |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tsunata, Ren| Takemoto, Masatsugu| Imai, Jun| Saito, Tatsuya| Ueno, Tomoyuki| |
| Keywords | Pressing Stator cores Magnetic cores Torque Atmospheric modeling Presses Manufacturing Mass production Axial-flux permanent magnet machine soft magnetic composite (SMC) PMSM tooth-tips torque press process semi-closed slot structure axial gap motor mass production YASA motor shoe |
| Published Date | 2023-10-04 |
| Publication Title | IEEE Access |
| Volume | volume11 |
| Publisher | Institute of Electrical and Electronics Engineers |
| Start Page | 109435 |
| End Page | 109447 |
| ISSN | 2169-3536 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| DOI | 10.1109/ACCESS.2023.3321829 |
| Web of Science KeyUT | 001086321100001 |
| Related Url | isVersionOf https://doi.org/10.1109/ACCESS.2023.3321829 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Keywords | Choledochal cyst Congenital biliary dilatation Robot Surgical approach |
| Published Date | 2023-10 |
| Publication Title | Asian Journal of Surgery |
| Volume | volume46 |
| Issue | issue10 |
| Publisher | Elsevier |
| Start Page | 4399 |
| End Page | 4402 |
| ISSN | 1015-9584 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Asian Surgical Association and Taiwan Robotic Surgery Association. |
| File Version | publisher |
| PubMed ID | 36801184 |
| DOI | 10.1016/j.asjsur.2023.02.021 |
| Web of Science KeyUT | 001088748000001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.asjsur.2023.02.021 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Morizane, Shin| Mukai, Tomoyuki| Sunagawa, Ko| Tachibana, Kota| Kawakami, Yoshio| Ouchida, Mamoru| |
| Keywords | epidermal keratinocytes input cytokines output cytokines biologics inflammatory skin diseases |
| Published Date | 2023-10-10 |
| Publication Title | Frontiers in Immunology |
| Volume | volume14 |
| Publisher | Frontiers Media |
| Start Page | 1239598 |
| ISSN | 1664-3224 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Morizane, Mukai, Sunagawa, Tachibana, Kawakami and Ouchida. |
| File Version | publisher |
| PubMed ID | 37881433 |
| DOI | 10.3389/fimmu.2023.1239598 |
| Web of Science KeyUT | 001090269600001 |
| Related Url | isVersionOf https://doi.org/10.3389/fimmu.2023.1239598 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Otani, Yusuke| Yoshikawa, Soichiro| Nagao, Kei| Tanaka, Takehiro| Toyooka, Shinichi| Fujimura, Atsushi| |
| Keywords | Mast cells Connective tissue mast cells Noradrenaline Immunoelectron microscopy SLC22A3 |
| Note | The version of record of this article, first published in The Journal of Physiological Sciences, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12576-023-00883-3| |
| Published Date | 2023-10-12 |
| Publication Title | The Journal of Physiological Sciences |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 24 |
| ISSN | 1880-6546 |
| NCID | AA12129145 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37828465 |
| DOI | 10.1186/s12576-023-00883-3 |
| Web of Science KeyUT | 001089236900002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12576-023-00883-3 |
| FullText URL | mjou_066_135_157.pdf |
|---|---|
| Author | Davis, Daniel G.| |
| Abstract | Let n ≥ 1, p a prime, and T(n) any representative of the Bousfield class of the telescope v−1n F(n) of a finite type n complex. Also, let En be the Lubin-Tate spectrum, K(En) its algebraic K-theory spectrum, and Gn the extended Morava stabilizer group, a profinite group. Motivated by an Ausoni-Rognes conjecture, we show that there are two spectral sequences IEs,t2 ⇒ πt−s((LT(n+1)K(En))hGn) ⇐ IIEs,t2 with common abutment π∗(−) of the continuous homotopy fixed points of LT(n+1)K(En), where IEs,t2 is continuous cohomology with coefficients in a certain tower of discrete Gn-modules. If the tower satisfies the Mittag-Leffler condition, then there are isomorphisms with continuous cochain cohomology groups: IE∗,∗2 ≅ H∗cts(Gn, π∗(LT(n+1)K(En))) ≅ IIE∗,∗2. We isolate two hypotheses, the first of which is true when (n, p) = (1, 2), that imply (LT(n+1)K(En))hGn ≃ LT(n+1)K(LK(n)S0). Also, we show that there is a spectral sequence Hscts(Gn, πt(K(En) ⊗ T(n + 1))) ⇒ πt−s((K(En) ⊗ T(n + 1))hGn). |
| Keywords | Algebraic K-theory spectrum continuous homotopy fixed point spectrum Lubin-Tate spectrum Morava stabilizer group homotopy fixed point spectral sequence telescopic localization |
| Published Date | 2024-01 |
| Publication Title | Mathematical Journal of Okayama University |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Department of Mathematics, Faculty of Science, Okayama University |
| Start Page | 135 |
| End Page | 157 |
| ISSN | 0030-1566 |
| NCID | AA00723502 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright ©2024 by the Editorial Board of Mathematical Journal of Okayama University |
| FullText URL | fulltext20231101-01.pdf |
|---|---|
| Author | Ren, Jianchao| Danchana, Kaewta| Sasaki, Keiko| Kaneta, Takashi| |
| Keywords | Laccase Mushroom Fluorometry 2,2'-Azinobis(3-ethylbenzthiazolin-6-sulfonic acid) N-Benzoyl leucomethylene blue |
| Note | © 2023 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Aug. 2024.| |
| Published Date | 2023-10 |
| Publication Title | Journal of Food Composition and Analysis |
| Volume | volume123 |
| Publisher | Elsevier BV |
| Start Page | 105627 |
| ISSN | 0889-1575 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Elsevier Inc. |
| File Version | author |
| DOI | 10.1016/j.jfca.2023.105627 |
| Web of Science KeyUT | 001068657200001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jfca.2023.105627 |
| FullText URL | fulltext20231030-01.pdf fig20231030-01.pdf table20231030-01.pdf suppl20231030-01.pdf |
|---|---|
| Author | Kakiuchi, Yoshihiko| Kuroda, Shinji| Choda, Yasuhiro| Otsuka, Shinya| Ueyama, Satoshi| Tanaka, Norimitsu| Muraoka, Atsushi| Hato, Shinji| Kamikawa, Yasuaki| Fujiwara, Toshiyoshi| |
| Keywords | Double -flap technique Gastric cancer Prognostic factor Prognostic nutritional index Proximal gastrectomy |
| Note | © 2023 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Sep. 2024.| |
| Published Date | 2023-10 |
| Publication Title | Surgical Oncology |
| Volume | volume50 |
| Publisher | Elsevier BV |
| Start Page | 101990 |
| ISSN | 0960-7404 |
| NCID | AA10850448 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Elsevier Ltd. |
| File Version | author |
| PubMed ID | 37717376 |
| DOI | 10.1016/j.suronc.2023.101990 |
| Web of Science KeyUT | 001082185900001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.suronc.2023.101990 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yumoto, Tetsuya| Hongo, Takashi| Koide, Yasuhiro| Obara, Takafumi| Tsukahara, Kohei| Naito, Hiromichi| Nakao, Atsunori| |
| Keywords | Emergency service Informed consent Radiation Treatment refusal |
| Note | The version of record of this article, first published in BMC Medical Ethics, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12910-023-00962-5| |
| Published Date | 2023-10-04 |
| Publication Title | BMC Medical Ethics |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 80 |
| ISSN | 1472-6939 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37794408 |
| DOI | 10.1186/s12910-023-00962-5 |
| Web of Science KeyUT | 001080177500004 |
| Related Url | isVersionOf https://doi.org/10.1186/s12910-023-00962-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tomita, Koji| Matsui, Yusuke| Uka, Mayu| Umakoshi, Noriyuki| Kawabata, Takahiro| Munetomo, Kazuaki| Nagata, Shoma| Iguchi, Toshihiro| Hiraki, Takao| |
| Keywords | Ablation Liver Metastasis |
| Note | The version of record of this article, first published in Japanese Journal of Radiology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11604-022-01335-5| |
| Published Date | 2022-09-13 |
| Publication Title | Japanese Journal of Radiology |
| Volume | volume40 |
| Issue | issue10 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1035 |
| End Page | 1045 |
| ISSN | 1867-1071 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 36097234 |
| DOI | 10.1007/s11604-022-01335-5 |
| Web of Science KeyUT | 000852956100003 |
| Related Url | isVersionOf https://doi.org/10.1007/s11604-022-01335-5 |
| JaLCDOI | 10.18926/AMO/65980 |
|---|---|
| FullText URL | 77_5_561.pdf |
| Author | Tsuchiya, Hiroki| Shibata, Takashi| Sasaki, Tatsuya| Inoue, Takushi| Date, Isao| Akiyama, Tomoyuki| Kobayashi, Katsuhiro| |
| Abstract | West syndrome, an infantile developmental and epileptic encephalopathy with a deleterious impact on long-term development, requires early treatment to minimize developmental abnormality; in such cases, epilepsy surgery should be considered a powerful therapeutic option. We describe a 10-month-old female admitted with West syndrome associated with a hemispheric lesion following abusive head trauma. Her seizures were suppressed by hemispherotomy at 12 months of age, leading to developmental improvement. Surgical treatment of West syndrome following traumatic brain injury has not been reported previously but is worth considering as a treatment option, depending on patient age and brain plasticity. |
| Keywords | abusive head trauma developmental and epileptic encephalopathy epilepsy surgery epileptic spasms hemispherotomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 561 |
| End Page | 566 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899268 |
| Web of Science KeyUT | 001110832700002 |
| JaLCDOI | 10.18926/AMO/65979 |
|---|---|
| FullText URL | 77_5_553.pdf |
| Author | Murokawa, Takahiro| Sakamoto, Shinya| Tabuchi, Motoyasu| Sui, Kenta| Ozaki, Kazuhide| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| Yoshida, Hiroshi| |
| Abstract | Gastric cancer with peritoneal metastases is typically a devastating diagnosis. Ligamentum teres hepatis (LTH) metastasis is an extremely rare presentation with only four known cases. Herein, we report salvage surgery of successive metastases to the abdominal wall and LTH in a patient originally presenting with advanced gastric cancer with peritoneal metastasis, leading to long-term survival. A 72-year-old man with advanced gastric cancer underwent curative-intent distal gastrectomy with D2 lymph node dissection for gastric outlet obstruction. During this procedure, three small peritoneal metastases were detected in the lesser omentum, the small mesentery, and the mesocolon; however, intraoperative abdominal lavage cytology was negative. We added cytoreductive surgery for peritoneal metastasis. The pathological diagnosis of the gastric cancer was tubular adenocarcinoma with pT4aN1pM1(PER/P1b)CY0 stage IV (Japanese classification of gastric carcinoma/JCGC 15th), or T4N1M1b stage IV (UICC 7th). Post-operative adjuvant chemotherapy with S-1 (TS-1)+cisplatin (CDDP) was administered for 8 months followed by S-1 monotherapy for 4 months. At 28 months after the initial surgery, a follow-up computed tomography (CT) detected a small mass beneath the upper abdominal wall. The ass showed mild avidity on 18F-fluorodeoxyglucose positron-emission (FDG-PET) CT. Salvage resection was performed for diagnosis and treatment, and pathological findings were consistent with primary gastric cancer metastasis. At 49 months after the initial gastrectomy, a new lesion was detected in the LTH with a similar level of avidity on FDG-PET CT as the abdominal wall metastatic lesion. We performed a second salvage surgery for the LTH tumor, which also showed pathology of gastric cancer metastasis. There has been no recurrence up to 1 year after the LTH surgery. With multidisciplinary treatment the patient has survived almost 5 years after the initial gastrectomy. Curative-intent gastrectomy with cytoreductive surgery followed by adjuvant chemotherapy for advanced gastric cancer with localized peritoneal metastasis might have had a survival benefit in our patient. Successive salvage surgeries for oligometastatic lesions in the abdominal wall and the LTH also yielded favorable outcomes. |
| Keywords | gastric cancer peritoneal metastasis ligamentum teres hepatis oligometastasis salvage surgery |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 553 |
| End Page | 559 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899267 |
| Web of Science KeyUT | 001110832700001 |
| JaLCDOI | 10.18926/AMO/65978 |
|---|---|
| FullText URL | 77_5_545.pdf |
| Author | Iwamuro, Masaya| Tanaka, Shouichi| Toyokawa, Tatsuya| Nishimura, Mamoru| Tsuzuki, Takao| Miyahara, Koji| Negishi, Shin| Ohya, Shogen| Tanaka, Takehiro| Otsuka, Motoyuki| |
| Abstract | To determine the endoscopic and clinical features of localized gastric amyloid light-chain (AL) amyloidosis, we retrospectively examined the characteristics of nine patients (eight men and one woman) encountered by the hospitals in our network. Lesions were predominantly flat and depressed with surface vascular dilatation (n=5); others were characterized by subepithelial lesions (n=2), mucosal color change (n=1), and a mass-like morphology with swollen mucosal folds (n=1). Colonoscopy (n=7), video capsule enteroscopy (n=2), serum (n=5) and urine immunoelectrophoresis (n=4), and bone marrow examination (n=3) were performed to exclude involvement of organs other than the stomach. As treatment for gastric lesions of AL amyloidosis, one patient each underwent endoscopic submucosal dissection (n=1) and argon plasma coagulation (n=1), while the remaining seven patients underwent no specific treatment. During a mean follow-up of 4.2 years, one patient died 3.2 years after diagnosis, but the cause of death, which occurred in another hospital, was unknown. The remaining eight patients were alive at the last visit. In conclusion, although localized gastric AL amyloidosis can show various macroscopic features on esophagogastroduodenoscopy, flat, depressed lesions with vascular dilatation on the surface are predominant. |
| Keywords | esophagogastroduodenoscopy gastric lesion amyloidosis light chain |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 545 |
| End Page | 552 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899266 |
| Web of Science KeyUT | 001094245100001 |
| JaLCDOI | 10.18926/AMO/65976 |
|---|---|
| FullText URL | 77_5_537.pdf |
| Author | Song, Qingqing| Pan, Yu| Kanazawa, Tomoyuki| Morimatsu, Hiroshi| |
| Abstract | Elderly patients are at higher risk of postoperative hypoxemia due to their decreased respiratory function. The aim of this study was to investigate the relationship of intraoperative oxygen saturation (SpO2) and end-expiratory carbon dioxide (ETCO2) values with postoperative hypoxemia in elderly patients. The inclusion criteria were: 1) patients aged≥75 years; 2) underwent general anesthesia in non-cardiac surgery; 3) operative time longer than two hours; and 4) admission to the intensive care unit (ICU) following surgery performed between January and December 2019. Intraoperative SpO2 and ETCO2 values were collected every minute for the first two hours during surgery. The 253 patients were divided into two groups: SpO2≥92% and SpO2<92%. The time-weighted averages of intraoperative SpO2 and ETCO2 were used to compare differences between the two groups. The incidence of postoperative hypoxemia was 22.5%. For similar ventilator settings, patients with postoperative hypoxemia had lower intraoperative SpO2 and higher ETCO2 values. Sex, ASA classification, and intraoperative SpO2 were independent risk factors for postoperative hypoxemia. In conclusion, postoperative SpO2<92% was a frequent occurrence (> 20%) in elderly patients who underwent major non-cardiac surgery. Postoperative hypoxemia was associated with low intraoperative SpO2 and relatively higher ETCO2. |
| Keywords | oxygen saturation end-expiratory carbon dioxide postoperative hypoxemia |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 537 |
| End Page | 543 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899265 |
| Web of Science KeyUT | 001108661600011 |
| JaLCDOI | 10.18926/AMO/65975 |
|---|---|
| FullText URL | 77_5_527.pdf |
| Author | Ando, Miho| Hanayama, Yoshihisa| Nishimura, Yoshito| Hagiya, Hideharu| Otsuka, Fumio| |
| Abstract | Retroperitoneal fibrosis (RPF) is a rare cause of hydronephrosis and progressive renal dysfunction with unidentified origin. RPF is categorized into idiopathic RPF with/without immunoglobulin G4 (IgG4)-related disease (IgG4-RD), and secondary RPF. Identifying the underlying cause is challenging and often associated with delayed diagnosis or therapeutic interventions. We investigated RPF’s clinical characteristics based on different etiologies and factors that may help distinguish the underlying causes. We analyzed the cases of 49 patients with RPF that was radiographically diagnosed at our institution (2008-2022). The cohort was 77.6% males; 75.5% had idiopathic RPF and 24.5% had secondary RPF. Among the idiopathic patients, 54.1% had IgG4-RD. The patients were likely to have abdominal pain, lower back pain/lumbago, and constitutional symptoms including generalized fatigue and fever. The idiopathic patients were likely to have higher serum IgG4 and IgG levels and lower serum C3 levels compared to secondary RPF. The IgG4-RPF patients were likely to have higher serum IgG4 levels and lower serum C-reactive protein, ferritin, and C3 levels compared to the idiopathic RPF patients without IgG4-RD. These findings might reflect underlying systemic inflammatory responses. Comprehensive laboratory testing, including serum inflammatory markers and immunological panels, is recommended for radiologically diagnosed RPF patients. |
| Keywords | retroperitoneal fibrosis IgG4-related disease malignancy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 527 |
| End Page | 536 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899264 |
| Web of Science KeyUT | 001108661600010 |
| JaLCDOI | 10.18926/AMO/65974 |
|---|---|
| FullText URL | 77_5_517.pdf |
| Author | Horiguchi, Shigeru| Matsumoto, Kazuyuki| Morimoto, Kosaku| Matsumi, Akihiro| Terasawa, Hiroyuki| Fujii, Yuki| Yamazaki, Tatsuhiro| Tsutsumi, Koichiro| Kato, Hironari| |
| Abstract | We investigated the effect of modified FOLFIRINOX (mFFX) in unresectable pancreatic cancer by retrospectively analyzing the cases of 43 patients who underwent BRCA testing (germline, n=11; somatic, n=26; both germline and somatic, n=6). The association between BRCA mutations and therapeutic effect was clarified. Six patients tested positive for germline pathogenic variants. Familial pancreatic cancer (33% vs. 3%, p=0.006) and peritoneal disseminated lesions (66% vs. 8%, p<0.001) were significantly more common in patients with germline pathogenic variants. The partial response (PR) rate was 100% in the germline BRCA-positive patients, and 27% in the germline BRCA-negative patients (p<0.001). The median progression-free survival (PFS) was not reached for any germline BRCA-positive patients but was 9.0 months for the germline BRCA-negative patients (p=0.042). Patients with stage IV BRCA-associated pancreatic cancer had better overall survival than those with non-BRCA-associated pancreatic cancer, although the difference was nonsignificant (not reached vs. 655 days, p=0.061). Our results demonstrate that a PR and prolonged PFS can be expected in germline BRCA-positive patients after treatment with mFFX. Our findings also suggest that germline BRCA pathogenic variants may be useful as biomarkers for the therapeutic effect of mFFX in patients with pancreatic cancer. |
| Keywords | BRCA FOLFIRINOX pancreatic cancer progression-free survival pathogenic variant |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 517 |
| End Page | 525 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899263 |
| Web of Science KeyUT | 001108661600009 |
| JaLCDOI | 10.18926/AMO/65973 |
|---|---|
| FullText URL | 77_5_511.pdf |
| Author | Sato, Kohei| Tsuji, Hironori| Yorimitsu, Masanori| Uehara, Takenori| Okazaki, Yuki| Takao, Shinichiro| Hata, Toshiaki| Fukuoka, Shiro| Noda, Tomoyuki| Kanda, Hideyuki| Ozaki, Toshifumi| |
| Abstract | Sarcopenia and malnutrition are increasing in older adults and are reported risk factors for functional impairment after hip fracture surgery. This study aimed to investigate the associations between skeletal muscle mass loss, malnutrition, and postoperative walking ability in patients with hip fracture. We retrospectively reviewed patients who underwent intertrochanteric fracture surgery at our institute. The psoas muscle index, controlling nutritional status score, and functional ambulation category (FAC) were used to evaluate skeletal muscle mass, nutritional status, and walking ability, respectively. Six months after surgery, walking ability was assessed as either “gait disturbance” or “independent gait”. Multivariate binomial logistic regression analysis, with skeletal muscle mass, nutritional status, and other factors, was used to predict the risk of being assigned to the gait disturbance group. This study included 95 patients (mean age, 85.2 years; 70 women). Sixty-six patients had low skeletal muscle mass, 35 suffered from malnutrition, and 28 had both. Malnutrition and low skeletal muscle mass were significantly associated with postoperative gait disturbance (FAC < 3). Preoperative low skeletal muscle mass and malnutrition were risk factors for postoperative poor walking ability. Further preventive interventions focusing on skeletal muscle mass and nutritional status are required. |
| Keywords | sarcopenia nutrition geriatric hip fracture psoas muscle index controlling nutritional status score |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 511 |
| End Page | 516 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899262 |
| Web of Science KeyUT | 001108661600008 |
| JaLCDOI | 10.18926/AMO/65972 |
|---|---|
| FullText URL | 77_5_499.pdf |
| Author | Hatakeyama, Yuji| Hongo, Michio| Kido, Tadato| Urayama, Masakazu| Kasukawa, Yuji| Sasaki, Hiroshi| Aizawa, Toshiaki| Kudo, Daisuke| Kimura, Ryota| Ono, Yuichi| Kasama, Fumihito| Miyakoshi, Naohisa| |
| Abstract | This study aimed to clarify neurological differences among the epiconus, conus medullaris, and cauda equina syndromes. Eighty-seven patients who underwent surgery for acute thoracolumbar spinal injuries were assessed. We defined the epiconus as the region from the terminal end of the spinal cord to the proximal 1.0 to 2.25 vertebral bodies, the conus medullaris as the region proximal to < 1.0 vertebral bodies, and the cauda equina as the distal part of the nerve roots originating from the spinal cord. On the basis of the distance from the terminal end of the spinal cord to the narrowest level of the spinal canal, the narrowest levels were ordered as follows: the epiconus followed by the conus medullaris and cauda equina. The narrowest levels were the epiconus in 22 patients, conus medullaris in 37 patients, and cauda equina in 25 patients. On admission, significantly more patients had a narrowed epiconus of Frankel grades A-C than a narrowed cauda equina. At the final follow-up, there were no significant differences in neurological recovery among those with epiconus, conus medullaris, or cauda equina syndrome. Anatomically classifying the narrowest lesion is useful for clarifying the differences and similarities among these three syndromes. |
| Keywords | thoracolumbar spinal injury terminal end of spinal cord conus medullaris epiconus syndrome cauda equina syndrome |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 499 |
| End Page | 509 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899261 |
| Web of Science KeyUT | 001108661600007 |
| JaLCDOI | 10.18926/AMO/65971 |
|---|---|
| FullText URL | 77_5_491.pdf |
| Author | Habu, Hiroshi| Takao, Soshi| Miyaji, Chikara| Matsumoto, Naomi| Aoo, Ken| Nishita, Yosuke| Tsuri, Masao| Yorifuji, Takashi| |
| Abstract | Arts festivals have become increasingly popular in various parts of Japan in recent years. The purpose of this study was to investigate the relationships between arts festival activities participation at the Setouchi Triennale and the health of residents in the town of Naoshima. This was a cross-sectional study. Questionnaires were distributed to all residents of Naoshima who were 20 years old or older (n=2,588). We analyzed responses from 708 people. The associations between arts festival activities participation and health (measured by self-rated health) were analyzed using logistic regression analysis as the primary outcome. Kessler’s psychological distress scale scores were also analyzed in the same manner as the primary outcome. The participating group had an adjusted odds ratio of 1.86 (95% confidence interval: 1.03-3.33) for higher self-rated health compared with those who did not participate. Kessler’s psychological distress scale results showed that the participating group had an adjusted odds ratio of 3.23 (95% confidence interval: 1.19-8.81) for lower psychological distress compared with those who did not participate. In conclusion, arts festival activities participation was associated with higher self-rated health and lower psychological distress. However, caution must be taken in regard to generalizability and causality when interpreting these results. |
| Keywords | art arts in public health arts festival self-rated health Setouchi Triennale |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 491 |
| End Page | 497 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899260 |
| Web of Science KeyUT | 001108661600006 |
| JaLCDOI | 10.18926/AMO/65970 |
|---|---|
| FullText URL | 77_5_479.pdf |
| Author | Murata, Akiko| Matsumoto, Naomi| Miyaji, Chikara| Takao, Soshi| Yorifuji, Takashi| |
| Abstract | For decades, the notion has persisted in developed countries that exclusive care by the mothers is best for the development of children up to 3 years of age. To examine the veracity of this “myth of the first three years” in Japan, we examined the effects of childcare facility use for children younger than 3 years on their development using the cohorts of the Longitudinal Survey of Newborns in the 21st Century conducted in Japan. Of the 47,015 respondents to the survey, we studied the children of 5,508 mothers with university/professional education to evaluate the relationships between primary early (< 2.5 years) childcare providers during weekday daytime hours and specific development indices for the ages of 2.5, 5.5, and 8 years. At the age of 2.5 and 5.5 years, children attending childcare facilities were judged as having more advanced developmental behaviors by their parents, such as being able to compose a two-word sentence (adjusted odds ratio [aOR]: 0.22) or to express emotions (aOR: 0.81), compared with those cared for by mothers. However, at the age of 8 years, children who attended childcare facilities as infants < 2.5 years showed more aggressive behavior in interrupting people (aOR: 1.20) and causing disturbances in public (aOR: 1.26) than those cared for by mothers (after adjustment for numerous child and parental factors). Although these results are generally consistent with previous studies, issues potentially involved with problem behavior such as quality of childcare require further investigation, as does the case of children of mothers with more modest educational attainment. |
| Keywords | “myth of the first three years” childcare child development problem behavior educational attainment |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 479 |
| End Page | 490 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899259 |
| Web of Science KeyUT | 001108661600005 |
