result 47892 件
| JaLCDOI | 10.18926/14841 |
|---|---|
| Title Alternative | Two male steroid-dependent asthmatics treated with etidronate |
| FullText URL | 72_062_065.pdf |
| Author | Tsugeno, Hirofumi| Okamoto, Makoto| Takata, Singo| Yokoi, Tadashi| Nishida, Kazunori| Ashida, Kozo| Hosaki, Yasuhiro| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Nakai, Mutsuo| Akiyama, Tsuneo| Hasegawa, Hisakazu| Tsuji, Takao| |
| Abstract | 男性のステロイド依存性気管支喘息患者にエチドロネートを4年間の長期間にわたり投与した経験を得たので報告する｡症例は,男性のステロイド依存性気管支喘息で,エチドロネート200mg/日･14日間投与を4ケ月おきに4年間にわたり反復投与し,活性型ビタミンD製剤 (VD)投与と併用した2例と,活性型VD製剤を単独授与した2例｡椎体圧迫骨折数,境骨耗骨密度,海綿骨骨密度,皮質骨骨密度について,椎体X線像,PQCT(Stratec XCT960)を用いて4ケ月毎に測定し,48ケ月後の効果を検討した｡エチドロネートを投与した症例1では,総骨密度と海綿骨はやや増加を認め皮質骨密度は減少していた｡エチドロネートを授与した症例2では,総骨密度,海綿骨,皮質骨密度はいずれも減少を認めたが,VD単独投与した2例よりもやや減少が抑制されていたようであった｡VD単独投与した2例ではいずれの項目も減少を認めた｡これらの症例からは,エチドロネートは男性のステロイドによる骨傷害にも有効と考えられたが,現在投与継続途中であり,今後さらに検討を続ける必要がある｡ |
| Keywords | エチドロネート 男性 ステロイド 気管支喘息 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 62 |
| End Page | 65 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308188 |
| JaLCDOI | 10.18926/14840 |
|---|---|
| Title Alternative | Multidetector-CT findings of dissecting aortic aneurysum and coronary artery disease. Based on the case of dissecting aortic aneurysum and coronary artery disease. |
| FullText URL | 72_055_061.pdf |
| Author | Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Takata, Shingo| Yokoi, Tadashi| Nakai, Mutsuo| Makino, Hirofumi| Tanizaki, Yoshiro| |
| Abstract | 2000年になり多列検出器高速CT (Multi-detector CT,以下MDCT)が出現し,大動脈疾患や心電図同期での冠動脈狭窄病変診断への臨床応用が開始された.当院でも2001年7月からMDCTが稼動し,日常臨床診療に貢献している. 今回,解離性上行大動脈瘤(DeBakeyII)(以下DAA)と冠動脈疾患(LAD# 7の閉塞)を合併した患者を診療した.MDCTによるCT - Angiography (以下CTA)が両者の診断に非常に有用であった.患者の負担は100mlの末梢静脈内への造影剤の投与と約数十秒間の呼吸停止だけで,解離性大動脈瘤並びに冠動脈狭窄病変の診断にそれぞれ非常に有用であった.三次元診断の鮮明な画像が得られ,かつ低侵襲度のMDCT並びにCTAは,今後益々臨床の場で血管造影検査の強力なファーストチョイスの診療手段になると考える. |
| Keywords | 解敵性大動脈瘤 (disecting aortic aneurysum) 冠動脈 (coronary artery) 狭心症 (anglna Pectoris) 多列検出器CT(マルチスライスCT) (MDCT) CT血管造影 (CT-Angiography) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 55 |
| End Page | 61 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308046 |
| JaLCDOI | 10.18926/14839 |
|---|---|
| Title Alternative | 脂質代謝に関連した気管支喘息患者における白血球ロイコトリエン産生能に対するα-リノレン酸食の効果 |
| FullText URL | 72_045_054.pdf |
| Author | Okamoto, Makoto| Mitsunobu, Fumihiro| Ashida, Kozo| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Nishida, Norikazu| Yokoi, Tadashi| Takata, Shingo| Tanizaki, Yoshiro| Tanimoto, Mitsune| |
| Abstract | Dietary sources of a -linolenic acid, such as perilla seed oil, may have the capacity to inhibit the generation of leukotrienes (LTs) by leucocytes in patients with
asthma, as has been reported with the consumption of other long - chain n- 3 fatty a-cids.
The factors affecting the suppression of leukotriene (LT) C4 generation by leucocytes were examined by comparing the clinical features of patients with asthma who had been given dietary perilla seed oil (n - 3 fatty acids). Group A consisted of patients in whom the leucocyte generation of dietary perilla seed oil LTC4 was suppressed by this procedure. Group B consisted of those in whom LTC4 generation was not suppressed. LTC4 generation by leucocytes significantly decreased in group A for two (P<0.05) and four weeks (P |
| Keywords | alpha -linolenic acid leukotrieneC4 bronchial asthma lipometabolism |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 45 |
| End Page | 54 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308212 |
| JaLCDOI | 10.18926/14838 |
|---|---|
| FullText URL | 72_038_044.pdf |
| Author | Ashida, Kozo| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| |
| Abstract | Changes in the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes after spa therapy were examined in 30 patients with asthma.
1. The efficacy of spa therapy was marked in 8 (26.7%), and moderate in 16 (53.3%) of 30 patients with asthma, and slight or no efficacy of the therapy was observed in the residual 6 patients (20.0%).
2. Bronchial reactivity to methacholine was the highest in
patients with slight or no efficacy of spa therapy, however. there were no significant differences among the three groups classified by clinical efficacy.
3. The generation of LTC4 was significantly higher in patients with slight or no efficacy compared with the
generation in those with marked (p |
| Keywords | asthma spa therapy bronchial hyperresponsiveness LTB4 LTC4 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 38 |
| End Page | 44 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308539 |
| JaLCDOI | 10.18926/14837 |
|---|---|
| FullText URL | 72_031_037.pdf |
| Author | Hosaki, Yasuhiro| Mitsunobu, Fumihiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| Ochi, Koji| Tsuji, Takao| |
| Abstract | The purpose of this study is to establish a new, non - invasive diagnostic technique for peripheral circulation in patients with diabetes mellitus in the early stage of arteriosclerosis obliterans (ASO) as one of the complications of diabetes mellitus. We observed peripheral circulation quantitatively by thermography and Laser- Doppler blood flowmetry. The body surface peripheral circulation in 27 patients with diabetes mellitus, including 14 males and 13 females with a mean age of 67.4 years (range from 51-82 years), and with a mean hemoglobin A1C (HbA1C) 019.5% (range from 6.8%-13.0%), and who were suffering coldness, numbness or pain in their feet, was examined using thermography and Laser- Doppler blood flowmetry. Thermographic results
were analyzed quantitatively by calculating a recovery ratio as : Recovery ratio= [Total counts of thermography (Pixels) over temperature (T) after cold -loading] + [Initial counts over T after hot-loading] Xl00 (%). Results of recovery ratios for 27 cases were 0% - 93.5%, and the average was 34.0%. At the same time, the blood flow after cold -loading was 0.91 - 5. 36ml/min/lOOg tissue and the average was 2.04ml/min/l00g tissue. We found that the recovery ratio
and the blood flow were correlated (r=O. 634, p |
| Keywords | diabetes mellitus (糖尿病) peripheral circulation (末梢循環) thermography (サーモグラフィー) Laser-Doppler blood flowmetry (レーザードプラー血流計) blood flow (血流量) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 31 |
| End Page | 37 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308058 |
| JaLCDOI | 10.18926/14836 |
|---|---|
| Title Alternative | 高齢者気管支喘息の臨床病態におけるロイコトリエンB4,C4の役割. 気道過敏性とFEV1.0%との関連 |
| FullText URL | 72_023_030.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| |
| Abstract | The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 67 patients with asthma. 1. The generation of leukotriene B4 (LTB4) by leucocytes was significantly more increased in patients with asthma than in those with pulmonary emphysema (PE) and healthy subjects. The generation of leukotriene C4 (LTC4) was also signficantly more increased in patients with asthma compared to the generation in those with PE and healthy subjects. The generation of both LTB4 and LTC4 was significantly more increased in patients with PE than in healthy subjects. 2. The generation of both LTB4 and LTC4 was larger in patients with asthma over age 70 than in those of other age groups, however, the difference was not significant. 3. The generation of LTC4 was significantly higher in attack stage than in non-attack stage in all age groups of patients with asthma, however, the generation of LTB4 was not significantly different between the two stages. 4. Bronchial hyperresponsiveness to methacholine in patients with asthma tended to decrease with aging, and the bronchial hyperresponsiveness was to a certain extent correlated with the generation of LTB4, but not LTC4. 5. The generation of LTC4 was correlated with value of FEV1.0%. These results may suggest that both LTB4 and LTC4 participate in the pathophysiology of asthma in the elderly. |
| Keywords | asthma LTB4 LTC4 FEV1.0% bronchial hyperresponsiveness |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 23 |
| End Page | 30 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308466 |
| JaLCDOI | 10.18926/14835 |
|---|---|
| Title Alternative | 気管支喘息における気管支肺胞洗浄液中の細胞成分に対する加齢および副腎皮質ホルモンの影響 |
| FullText URL | 72_016_022.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Tanizaki, Yoshiro| |
| Abstract | Effects of aging and glucocorticoid therapy on bronchoalveolar lavage (BAL) cells, particularly lymphocytes, neutrophils and eosinophils, were examined in 81 patients with asthma. 1. The proportion of BAL lymphocytes tended to increase with aging in asthmatics under age 69 years, and the proportion was significantly higher in patients with asthma between the ages of 60 and 69 than in those under age 39 and between the ages of 40 and 49. 2. The proportions of BAL neutrophils and eosinophils were not related to aging. 3. The proportion of BAL lymphocytes was higher in patients without glucocorticoid therapy than in those with steroid-dependent intractable asthma (SOIA) in those under age 69 years. In patients between the ages of 50 and 59, the proportion of BAL lymphocytes was significantly higher in patients without glucocorticoids than in those with SOIA. 4. The proportion of BAL neutrophils was higher in patients without glucocorticoid therapy than in those with SOIA, and the difference was significant in patients between the ages of 60 and 69. 5. The proportion of BAL eosinophils was not related to glucocorticoid therapy. These results suggest that the proportion of BAL lymphocytes and neutrophils is affected by aging and glucocorticoid therapy, but not BAL eosinophils. |
| Keywords | aging asthma glucocorticoid therapy BAL cells |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 16 |
| End Page | 22 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308605 |
| JaLCDOI | 10.18926/14834 |
|---|---|
| Title Alternative | HRCT上の肺のLow Attenuation Areaおよび肺機能により評価された高齢者善喘息の特徴 |
| FullText URL | 72_009_015.pdf |
| Author | Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| Nakai, Mutsuo| Tanizaki, Yoshiro| |
| Abstract | The clinical significance of low attenuation area <-950 HU of the lungs on high - resolution computed tomography (HRCT) was evaluated in 80 patients with asthma in relation to patient age, CT number, pulmonary function including % residusal volume (% RV) and % DLco, and generation of leukotrienes B4 and C4 by leucocytes.
1. The % LAA (<- 950 HU) of the lungs showed a tendency to increase significantly with aging; the % LAA was significantly larger in elderly patients over the age of 60 years than in those under the age of 49 years. The CT number was also significantlyincreased with aging.
2. The values of % FVC, % FEV1.0, and FEV1.0% were
significantly decreased in elderly patients over age 70 compared with the values in those under age 49.
3. The value of % residual volume (% RV) tended to increase significantly with aging; the value in patients over the age of 70 years was significantly larger in those between the ages of 50 and 59 (p |
| Keywords | low attenuation area of the lung CT number residual volume DLco aging |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 9 |
| End Page | 15 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308131 |
| Author | Matsuo Tetsuko| Murata, Atsuo| |
|---|---|
| Published Date | 2008-12-11 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | A.I.. ABDUL| Murata, Atsuo| A.E. OLULEYE| |
|---|---|
| Published Date | 2008-12-11 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Ohta Yukio| Murata, Atsuo| |
|---|---|
| Published Date | 2008-12-11 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Nishimura, Tokue| Handa, Hisashi| |
|---|---|
| Published Date | 2008-12-11 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Ishii Masataka| Tanaka Yoshiyuki| Tsuji Toshio| Imamura Nobuaki| |
|---|---|
| Published Date | 2008-12-11 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Tanaka Go| Suetake Noriaki| Uchino Eiji| |
|---|---|
| Published Date | 2008-12-11 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Tanaka Go| Suetake Noriaki| Uchino Eiji| |
|---|---|
| Published Date | 2008-12-11 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Mehdi Eghbal| Yorino Naoto| Zoka Yoshifumi| |
|---|---|
| Published Date | 2008-12-11 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Ishimatsu Jun| Katagiri Hideki| Nishizaki Ichiro| Hayashida Tomohiro| |
|---|---|
| Published Date | 2008-12-11 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| Author | Yamaguchi Daisuke| Katayama Fumiyo| Takahashi Muneo| Arai Masataka| Kenneth James Mackin| |
|---|---|
| Published Date | 2008-12-11 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
| JaLCDOI | 10.18926/14822 |
|---|---|
| Title Alternative | Spa therapy for patients with respiratory disease. Analysis of 1934 patients admitted at Misasa Medical Branch for last 20 years from 1982 to 2001 |
| FullText URL | 72_001_008.pdf |
| Author | Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Nishida, Norikazu| Takata, Shingo| Yokoi, Tadashi| |
| Abstract | 1982年1月より2001年12月までの20年間に当院へ入院した呼吸器疾患患者1934例のうち閉塞性換気障害を示す肺疾患1641例(気管支喘息BA+慢性閉塞性呼吸器疾患COPD)を対象に,5年間ごとに年齢,地域分布などの経年変化について検討を加えた｡ 1.最近20年間に当院へ入院した閉塞性換気障害を示す呼吸器疾患1641例のうち,気管支喘息は1226例(74.7%)であった｡閉塞性呼吸器疾患のなかで気管支喘息の占める割合は,最初の5年間では106例中 57例(53.8%),1987年からの5年間では71.7% (271/378),1992年からの5年間では73.6% (433/588)で,最近の5年間では53.9% (465/862)と最近ではその割合がやや低下する傾向が見られた｡ 2.全ての気管支喘息のなかでステロイド依存性重症難治性喘息(SDIA)の割合は,最初の5年間をのぞけばほぼ横ばいで最近の5年間では35.3%であった｡COPDのなかでの肺気腫の割合は,近年増加の傾向を示し,最初の5年間の4.7% (5/106)に対して最近の5年間では20.2% (174/862)であった｡ 3.年齢別検討では,閉塞性換気障害を示す全ての症例のうち60才以上の症例の割合は,最初の5年間では30.1%であったが,その後増加の傾向を示し,最近の5年間では68.0%であった｡ 4.地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,この20年間の鳥取県外(遠隔地)からの入院患者は1641例中853例(52.0%)であった｡また,岡山,大阪,広 島,兵庫,東京,愛媛,山口,京都などからの入院症例が多い傾向が見られた｡なお,入院患者の出身県は,35都道府県に及んでいた｡ |
| Keywords | 気管支喘息 (asthma) 肺気腫 (pulmonary emphysema) 温泉療法 (Spa therapy) 高齢患者 (aged patients) 遠隔地 (distant area) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2002-02-01 |
| Volume | volume72 |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308041 |
| Author | Niimi Ayahiko| Saito Yusaku| Konishi Osamu| |
|---|---|
| Published Date | 2008-12-11 |
| Publication Title | Proceedings : Fourth International Workshop on Computational Intelligence & Applications |
| Volume | volume2008 |
| Issue | issue1 |
| Content Type | Conference Paper |
