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ID 31506
JaLCDOI
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Author
Takahashi, Isao
Ohmoto, Eijiro
Aoyaka, Shigeo
Takizawa, Michihiro
Oda, Yasuhiro
Nonaka, Kenichi
Nakada, Hiroyuki
Yorimitsu, Seiichi
Abstract

Age-related alterations in the host defense system have been vigorously investigated because of increased susceptibility to infection and neoplasms in the aged. Although monocyte-macrophages form a major part of the cellular defense against microorganisms, the majority of investigations has been limited to neutrophils and lymphocytes. The present study, designed to determine the influence of age on mononuclear phagocytes, revealed no significant decrease in the absolute number of blood monocytes, but did reveal a tendency for the chemiluminescence of blood monocytes to decrease (p less than 0.10) and a significant decrease in the numbers of macrophage precursors (p less than 0.05) in the aged (over 70 year old), in comparison with controls (under 40 years old). On the basis of these findings, functional alterations of monocyte-macrophages seem to participate in the increased susceptibility to infection in the aged.

Keywords
monocyte chemiluminescence
macrophage precursor
monocyte function in the aged
susceptibility to infection in the aged
Amo Type
Article
Publication Title
Acta Medica Okayama
Published Date
1985-12
Volume
volume39
Issue
issue6
Publisher
Okayama University Medical School
Start Page
447
End Page
451
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
English
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT