ID | 31506 |
JaLCDOI | |
FullText URL | |
Author |
Takahashi, Isao
Ohmoto, Eijiro
Aoyaka, Shigeo
Takizawa, Michihiro
Oda, Yasuhiro
Nonaka, Kenichi
Nakada, Hiroyuki
Yorimitsu, Seiichi
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Abstract | Age-related alterations in the host defense system have been vigorously investigated because of increased susceptibility to infection and neoplasms in the aged. Although monocyte-macrophages form a major part of the cellular defense against microorganisms, the majority of investigations has been limited to neutrophils and lymphocytes. The present study, designed to determine the influence of age on mononuclear phagocytes, revealed no significant decrease in the absolute number of blood monocytes, but did reveal a tendency for the chemiluminescence of blood monocytes to decrease (p less than 0.10) and a significant decrease in the numbers of macrophage precursors (p less than 0.05) in the aged (over 70 year old), in comparison with controls (under 40 years old). On the basis of these findings, functional alterations of monocyte-macrophages seem to participate in the increased susceptibility to infection in the aged. |
Keywords | monocyte chemiluminescence
macrophage precursor
monocyte function in the aged
susceptibility to infection in the aged
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Amo Type | Article
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Publication Title |
Acta Medica Okayama
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Published Date | 1985-12
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Volume | volume39
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Issue | issue6
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Publisher | Okayama University Medical School
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Start Page | 447
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End Page | 451
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |