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JaLCDOI 10.18926/AMO/62806
FullText URL 75_6_677.pdf
Author Tani Kazumasa| Mitsui, Takashi| Mishima, Sakurako| Ohira, Akiko| Maki, Jota| Eto, Eriko| Hayata, Kei| Nakamura, Keiichiro| Masuyama, Hisashi|
Abstract Extravillous trophoblast (EVT) invasion is important for embryo implantation, placental development, and successful remodeling of the uterine spiral artery. Endocrine gland derived-vascular endothelial growth factor (EG-VEGF) and matrix metalloproteinases (MMPs) are implicated in EVT invasion; however, the high con-centrations found in pregnancy pathologies have not been investigated in non-tumor trophoblasts. The roles of EG-VEGF, prokineticin receptors (PROKR1/2), MMP-2, and MMP-9 in EVT invasion during spiral artery remodeling were evaluated using human EVT from HTR-8/SVneo cell lines. The expression of MMP-2, MMP-9, and mitogen-activated protein kinase (MAPK), and Akt pathways in HTR-8/SVneo cells treated with recom-binant EG-VEGF alongside anti-PROKR1 and/or anti-PROKR2 antibodies was evaluated using quantitative reverse transcription-PCR and western blotting. Wound-healing and cell invasion assays were performed to assess the migration and invasion of these treated cells. Interestingly, 20 nM EG-VEGF activated ERK1/2 sig-naling and upregulated MMP-2 and MMP-9. This effect was suppressed by anti-PROKR2 antibody via ERK1/2 downregulation. Anti-PROKR2 antibody inhibited the migration and invasion of EG-VEGF-stimulated HTR-8/SVneo cells. Elevated concentrations of EG-VEGF enhance EVT invasion in a human trophoblast cell line by upregulating MMP-2 and MMP-9 via PROKR2. These new insights into the regulation of epithelial cell invasion may help in developing therapeutic interventions for placental-related diseases during pregnancy.
Keywords endocrine gland-derived vascular endothelial growth factor prokineticin extravillous trophoblast matrix metalloproteinase obstetric diseases
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-12
Volume volume75
Issue issue6
Publisher Okayama University Medical School
Start Page 677
End Page 684
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34955534
Web of Science KeyUT 000735297900002
NAID 120007180286
FullText URL fulltext.pdf
Author Inai, Ryota| Nakahara, Ryuichi| Morimitsu, Yusuke| Akagi, Noriaki| Marukawa, Youhei| Matsushita, Toshi| Tanaka, Takashi| Tada, Akihiro| Hiraki, Takao| Nasu, Yoshihisa| Nishida, Keiichiro| Ozaki, Toshifumi| Kanazawa, Susumu|
Keywords Osteoporosis Bone density Tomography (x-ray computed) X-ray microtomography
Published Date 2021-01-28
Publication Title European Radiology Experimental
Volume volume4
Issue issue1
Publisher Springer nature
Start Page 4
ISSN 2509-9280
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 31993864
DOI 10.1186/s41747-019-0135-0
Web of Science KeyUT 000705622700001
Related Url isVersionOf https://doi.org/10.1186/s41747-019-0135-0
FullText URL fulltext20211019-1.pdf
Author Miyajima, Mizuki| Astuti, Fahmi| Fukuda, Takahito| Kodani, Masashi| Iida, Shinsuke| Asai, Shinichiro| Matsuo, Akira| Masuda, Takatsugu| Kindo, Koichi| Hasegawa, Takumi| Kobayashi, Tatsuo C.| Nakano, Takehito| Watanabe, Isao| Kambe, Takashi|
Published Date 2021-10-7
Publication Title Physical Review B
Volume volume104
Issue issue14
Publisher American Physical Society (APS)
Start Page L140402
ISSN 2469-9950
NCID AA11187113
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders ©2021 American Physical Society
File Version publisher
DOI 10.1103/physrevb.104.l140402
Web of Science KeyUT 000704785600002
Related Url isVersionOf https://doi.org/10.1103/physrevb.104.l140402
FullText URL fulltext20211015-2.pdf
Author Seetasang, Sasikarn| Kaneta, Takashi|
Keywords Diquat Dithiothreitol Light-emitting diode Paraquat Photometric detector Sodium dithionite
Note © 2021 Published by Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.microc.2021.106777] .
This fulltext is available in Sep. 2023.|
Published Date 2021-12
Publication Title Microchemical Journal
Volume volume171
Publisher Elsevier BV
Start Page 106777
ISSN 0026-265X
NCID AA00738394
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Published by Elsevier B.V.
File Version author
DOI 10.1016/j.microc.2021.106777
Web of Science KeyUT 000701672500002
Related Url isVersionOf https://doi.org/10.1016/j.microc.2021.106777
FullText URL fulltext20211006-2a.pdf
Author Kamada, Yasuhiko| Kusumoto, Rie| Kashino, Chiaki| Kubo, Kotaro| Mitsui, Takashi| Masuyama, Hisashi|
Keywords double cross plasty genital chronic graft-versus-host disease hematocolpos hematopoietic stem cell transplantation vaginal reconstruction
Note This is the peer reviewed version of the following article: [Kamada, Y., Kusumoto, R., Kashino, C., Kubo, K., Mitsui, T., & Masuyama, H. (2021). Surgically treated genital chronic graft‐versus‐host disease in women: A report of three cases. Journal of Obstetrics and Gynaecology Research.], which has been published in final form at [https://doi.org/10.1111/jog.15005]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-ArchivedVersions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wileyor by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked toWiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof bythird parties from platforms, services and websites other than Wiley Online Library must be prohibited.|
Published Date 2021-09-05
Publication Title Journal of Obstetrics and Gynaecology Research
Volume volume47
Issue issue11
Publisher Wiley
Start Page 4122
End Page 4126
ISSN 1341-8076
NCID AA11082002
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Japan Society of Obstetrics and Gynecology
File Version author
PubMed ID 34482585
DOI 10.1111/jog.15005
Web of Science KeyUT 000697443000001
Related Url isVersionOf https://doi.org/10.1111/jog.15005
FullText URL fulltext.pdf
Author Obara, Takafumi| Naito, Hiromichi| Tsukahara, Kohei| Matsumoto, Naomi| Yamamoto, Hirotsugu| Yorifuji, Takashi| Nakao, Atsunori|
Keywords sleep habits trauma problematic behavior longitudinal study
Published Date 2021-09-09
Publication Title International Journal of Environmental Research
Volume volume18
Issue issue18
Publisher MDPI
Start Page 9512
ISSN 1660-4601
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 34574435
DOI 10.3390/ijerph18189512
Web of Science KeyUT 000699559600001
Related Url isVersionOf https://doi.org/10.3390/ijerph18189512
FullText URL fulltext.pdf
Author Matsumoto, Naomi| Kadowaki, Tomoka| Tsukahara, Hirokazu| Yorifuji, Takashi|
Keywords dental caries influenza birth cohort oral health
Published Date 2021-09-06
Publication Title Children-Basel
Volume volume8
Issue issue9
Publisher MDPI
Start Page 780
ISSN 2227-9067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 34572212
DOI 10.3390/children8090780
Web of Science KeyUT 000699412100001
Related Url isVersionOf https://doi.org/10.3390/children8090780
FullText URL fulltext.pdf
Author Naito, Hiromichi| Yumoto, Tetsuya| Yorifuji, Takashi| Nojima, Tsuyoshi| Yamamoto, Hirotsugu| Yamada, Taihei| Tsukahara, Kohei| Inaba, Mototaka| Nishimura, Takeshi| Uehara, Takenori| Nakao, Atsunori|
Keywords Mortality Trauma care Cardiac arrest Time-to-treatment
Published Date 2021-09-16
Publication Title BMC Emergency Medicine
Volume volume21
Issue issue1
Publisher BMC
Start Page 104
ISSN 1471-227X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2021
File Version publisher
PubMed ID 34530735
DOI 10.1186/s12873-021-00499-z
Web of Science KeyUT 000696533900001
Related Url isVersionOf https://doi.org/10.1186/s12873-021-00499-z
FullText URL fulltext.pdf
Author Nishida, Takashi| Akashi, Sho| Takigawa, Masaharu| Kubota, Satoshi|
Keywords angiotensin II cellular communication network factor 2 (CCN2) renin-angiotensin system (RAS) losartan angiotensin II type I receptor (AT(1)R)
Published Date 2021-08-25
Publication Title International Journal of Molecular Sciences
Volume volume22
Issue issue17
Publisher MDPI
Start Page 9204
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 34502113
DOI 10.3390/ijms22179204
Web of Science KeyUT 000694359000001
Related Url isVersionOf https://doi.org/10.3390/ijms22179204
FullText URL fulltext.pdf
Author Kikuchi, Masuzu| Kojima, Keiichi| Nakao, Shin| Yoshizawa, Susumu| Kawanishi, Shiho| Shibukawa, Atsushi| Kikukawa, Takashi| Sudo, Yuki|
Published Date 2021-07-20
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Portfolio
Start Page 14765
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 34285294
DOI 10.1038/s41598-021-94181-w
Web of Science KeyUT 000692201200025
Related Url isVersionOf https://doi.org/10.1038/s41598-021-94181-w
JaLCDOI 10.18926/AMO/62406
FullText URL 75_4_523.pdf
Author Yamashita, Mampei| Kuroki, Tamotsu| Matsuoka, Yuki| Miura, Shiro| Hamada, Takashi| Hirayama, Takanori| Yoneda, Akira| Tokunaga, Takayuki| Yamanouchi, Kosho| Takeshita, Hiroaki| Maeda, Shigeto|
Abstract Acute mesenteric ischemia (AMI) is often caused by superior mesenteric artery (SMA) embolization. We report a rare case of synchronous celiac axis and SMA embolization in an elderly woman with initially mild abdominal pain. Ultimately, a second contrast-enhanced computed tomography revealed extensive necrosis from the stomach to the transverse colon together with liver ischemia due to hours of occlusion. Multiorgan failure made palliation the only option, and she died the following evening. Autopsy revealed a fragile atherosclerosis-asso-ciated thrombus. Careful examination and repeat diagnostic tests should be performed in patients with mild abdominal symptoms at risk for AMI.
Keywords atherosclerosis celiac axis mesenteric ischemia superior mesenteric artery thromboembolism
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-08
Volume volume75
Issue issue4
Publisher Okayama University Medical School
Start Page 523
End Page 527
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34511621
Web of Science KeyUT 000709282300007
NAID 120007146032
JaLCDOI 10.18926/AMO/62400
FullText URL 75_4_479.pdf
Author Harada, Akio| Kawai, Nobuyuki| Ogawa, Tomoya| Hatakeyama, Tetsuhiro| Tamiya, Takashi|
Abstract Instances of traumatic brain injury (TBI) in the elderly have been increasing along with the aging of popula-tions. In the present study, we examined the effect of aging on long-term multidisciplinary in-patient rehabili-tation efficacy after TBI. Sixty-three patients with physical and cognitive impairments after TBI were enrolled in this study. Patients were divided into 4 age groups (≤ 24, 25-44, 45-64, ≥ 65 years) and the clinical charac-teristics and rehabilitation efficacy of each age group were determined. Functional disability was evaluated using motor and cognitive Functional Independence Measure (FIM) scores. Rehabilitation efficacy was assessed by FIM gains during rehabilitation and compared among the groups. There were no statistically significant dif-ferences in motor and cognitive FIM gains among the age groups. However, cognitive FIM gain was limited in a subset of ≥ 65 patients, and initial cognitive measures could not predict cognitive FIM improvement. These results indicate that chronological age is insufficient to accurately predict rehabilitation efficacy in older TBI patients, and that such patients should be considered candidates for intensive rehabilitation programs based on these results. Accurate prognostication of rehabilitation efficacy with continuing data collection is important when using rehabilitation resources for older TBI patients.
Keywords aging Functional Independence Measure physical and cognitive impairments traumatic brain injury rehabilitation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-08
Volume volume75
Issue issue4
Publisher Okayama University Medical School
Start Page 479
End Page 486
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34511615
Web of Science KeyUT 000709282300001
NAID 120007146043
JaLCDOI 10.18926/AMO/62398
FullText URL 75_4_461.pdf
Author Murakami, Hiroyuki| Yoshioka, Takanori| Moriyama, Takashi| Ishikawa, Tatsunori| Makita, Masanori| Sunami, Kazutaka|
Abstract Bendamustine plus rituximab (B-R) is an effective therapy for relapsed or refractory (r/r) low-grade B-cell lymphoma (LGBCL) and mantle cell lymphoma (MCL); however, clinical data from Japanese patients treated with B-R therapy are limited. We retrospectively evaluated the efficacy and safety of B-R therapy in 42 patients who received B-R therapy at our hospital for r/r LGBCL and MCL. All patients received intravenous (IV) ritux-imab 375 mg/m2 on day 1 and IV bendamustine 90 mg/m2 on days 2 and 3 every 28 days for up to 6 cycles. The common histologic subtypes were follicular lymphoma (n = 29, 70%), marginal zone lymphoma (n = 6, 14%), and MCL (n = 5, 12%). The overall response rate was 93%, with 62% complete response and complete response unconfirmed. The median progression-free survival (PFS) was 38 months (95% confidence interval [CI], 24.6 to not reached [NR]), and the median overall survival (OS) was 80 months (95% CI, 60.7 to NR). Patients receiving a cumulative dose of bendamustine ≥ 720 mg/m2 showed a significantly longer PFS and OS. Grade 3/4 adverse events (≥ 10%) included neutropenia (55%), lymphopenia (69%), and nausea (24%). B-R therapy was effective and well tolerated, and the cumulative dose of bendamustine was associated with a favorable outcome.
Keywords bendamustine low grade B-cell lymphoma mantle cell lymphoma
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-08
Volume volume75
Issue issue4
Publisher Okayama University Medical School
Start Page 461
End Page 469
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34511613
Web of Science KeyUT 000697944600008
NAID 120007146041
JaLCDOI 10.18926/AMO/62395
FullText URL 75_4_439.pdf
Author Mitsui, Takashi| Mishima, Sakurako| Tani, Kazumasa| Maki, Jota| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi|
Abstract Early diagnosis and therapy are important in a cesarean scar pregnancy (CSP), which can cause uterine rupture with resultant massive bleeding. However, there are some reports of CSPs continued to term. The optimal management of CSPs remains unclear; therefore, we investigated the clinical courses of CSPs diagnosed and treated at perinatal institutions in the Chugoku and Shikoku regions of Japan. We enrolled 60 women diag-nosed with CSP at 21 institutions from January 2006 to December 2015. Of the 60 women diagnosed with CSP, 57 were treated. Pregnancy was terminated in 48 women and continued in 9. Thirteen women underwent transabdominal hysterectomy; they experienced no postoperative complications or allogeneic blood transfu-sion. Nine women received therapies such as dilation and curettage, and 26 received non-surgical therapies such as methotrexate and topical administration of potassium chloride. Among 9 women who chose to con-tinue with their CSP, 7 successfully delivered newborns, 2 had uterine ruptures in the second trimester, and all women required transabdominal hysterectomy. Diagnosis and therapy in the first trimester of pregnancy are important in the management strategy of a CSP. When continuing a CSP, the risk of uterine rupture and trans-abdominal hysterectomy must be considered.
Keywords cesarean scar pregnancy uterine rupture hysterectomy methotrexate potassium chloride
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-08
Volume volume75
Issue issue4
Publisher Okayama University Medical School
Start Page 439
End Page 445
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34511610
Web of Science KeyUT 000697944600005
NAID 120007146038
FullText URL fulltext.pdf
Author Ichikawa, Keishi| Miyoshi, Toru| Osawa, Kazuhiro| Miki, Takashi| Morimitsu, Yusuke| Akagi, Noriaki| Nakashima, Mitsutaka| Ito, Hiroshi|
Keywords coronary computed tomography angiography non-alcoholic fatty liver disease perivascular coronary inflammation
Published Date 2021-08-27
Publication Title Medicine
Volume volume100
Issue issue34
Publisher Lippincott Williams & Wilkins
Start Page e27043
ISSN 0025-7974
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 the Author(s).
File Version publisher
PubMed ID 34449489
DOI 10.1097/MD.0000000000027043
Web of Science KeyUT 000691370700047
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000027043
FullText URL fulltext.pdf
Author Yamamoto, Norio| Sukegawa, Shintaro| Yamashita, Kazutaka| Manabe, Masaki| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Ozaki, Toshifumi| Kawasaki, Keisuke| Nagatsuka, Hitoshi| Furuki, Yoshihiko| Yorifuji, Takashi|
Keywords patient variables osteoporosis deep learning convolutional neural network ensemble model effect size
Published Date 2021-08-20
Publication Title Medicina-Lithuania
Volume volume57
Issue issue8
Publisher MDPI
Start Page 846
ISSN 1010-660X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 34441052
DOI 10.3390/medicina57080846
Web of Science KeyUT 000689547600001
Related Url isVersionOf https://doi.org/10.3390/medicina57080846
FullText URL fulltext.pdf
Author Hutami, Islamy Rahma| Izawa, Takashi| Khurel-Ochir, Tsendsuren| Sakamaki, Takuma| Iwasa, Akihiko| Tanaka, Eiji|
Keywords HIF1 M1/M2 macrophage S1P wound healing
Published Date 2021-08-20
Publication Title International Journal of Molecular Sciences
Volume volume22
Issue issue16
Publisher MDPI
Start Page 8992
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 34445695
DOI 10.3390/ijms22168992
Web of Science KeyUT 000689169900001
Related Url isVersionOf https://doi.org/10.3390/ijms22168992
FullText URL fulltext.pdf
Author Yoshikawa, Yuri| Izawa, Takashi| Hamada, Yusaku| Takenaga, Hiroko| Wang, Ziyi| Ishimaru, Naozumi| Kamioka, Hiroshi|
Published Date 2021-07-21
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Portfolio
Start Page 14927
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 34290363
DOI 10.1038/s41598-021-94470-4
Web of Science KeyUT 000687318300008
Related Url isVersionOf https://doi.org/10.1038/s41598-021-94470-4
FullText URL fulltext20210811-16.pdf
Author Ishihara, Takashi| Sato, Masaya| Yamauchi, Toshihiro|
Keywords Malicious Websites Blacklist Web-based Attack Android
Note © 2020 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
This fulltext is available in Nov. 2022.|
7th International Workshop on Information and Communication Security (WICS 2020), Naha, Japan, 24-27 Nov. 2020|
Published Date 2020-11
Publication Title 2020 Eighth International Symposium on Computing and Networking Workshops (CANDARW)
Publisher IEEE
Start Page 20489448
Content Type Conference Paper
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 IEEE
File Version author
DOI 10.1109/candarw51189.2020.00070
Related Url isVersionOf https://doi.org/10.1109/candarw51189.2020.00070
FullText URL fulltext.pdf
Author Hongo, Takashi| Naito, Hiromichi| Fujiwara, Toshifumi| Naito, Takaki| Homma, Yosuke| Fujimoto, Yoshihisa| Takaya, Morooka| Yamamori, Yuji| Nakada, Taka-Aki| Nojima, Tsuyoshi| Nakao, Atsunori| Fujitani, Shigeki| In-Hospital Emergency Study Group|
Keywords discharge to home DNAR RRS serious adverse event
Published Date 2021-08-16
Publication Title Acute Medicine & Surgery
Volume volume8
Issue issue1
Publisher Wiley
Start Page e690
ISSN 2052-8817
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Authors.
File Version publisher
DOI 10.1002/ams2.690
Web of Science KeyUT 000685164200001
Related Url isVersionOf https://doi.org/10.1002/ams2.690