検索結果 - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Clinical Outcomes of Neoadjuvant Paclitaxel/Cisplatin/Gemcitabine Compared with Gemcitabine/Cisplatin for Muscle-Invasive Bladder Cancer

JaLCDOI	10.18926/AMO/68646
FullText URL	79_2_081.pdf
Author	Kawada, Tatsushi\| Kobayashi, Yasuyuki\| Tsugawa, Takuji\| Tsuboi, Kazuma\| Katayama, Satoshi\| Iwata, Takehiro\| Bekku, Kensuke\| Kobayashi, Tomoko\| Edamura, Kohei\| Ebara, Shin\| Araki, Motoo\|
Abstract	We retrospectively evaluated the oncologic outcomes of paclitaxel, cisplatin, and gemcitabine (PCG) with those of gemcitabine and cisplatin (GC) as neoadjuvant chemotherapy in muscle-invasive bladder cancer (MIBC) patients. The primary outcome was efficacy: pathological complete response (pCR), ypT0N0; and pathological objective response (pOR), ypT0N0, ≤ ypT1N0, or ypT0N1. Secondary outcomes included overall survival (OS), recurrence-free survival (RFS), predictive factors for pOR, OS, and RFS, and hematologic adverse events (AEs). Among 113 patients treated (PCG, n=28; GC, n=85), similar pOR and pCR rates were achieved by the groups (pOR: PCG, 57.1% vs. GC, 49. 4%; p=0.52; pCR: PCG, 39.3% vs. GC, 29.4%; p=0.36). No significant differences were observed in OS (p=1.0) or RFS (p=0.20). Multivariate logistic regression analysis showed that hydronephrosis (odds ratio [OR] 0.32, 95%CI: 0.11-0.92) and clinical node-positive status (cN+) (OR 0.22, 95%CI: 0.050-0.99) were significantly associated with a decreased probability of pOR. On multivariate Cox regression analyses, pOR achievement was associated with improved OS (hazard ratio [HR] 0.23, 95%CI: 0.10-0.56) and RFS (HR 0.30, 95%CI: 0.13-0.67). There were no significant between-group differences in the incidence of grade ≥ 3 hematologic AEs or dose-reduction required, but the PCG group had a higher incidence of grade 4 neutropenia.
Keywords	urothelial carcinoma paclitaxel cisplatin gemcitabine neoadjuvant
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2025-04
Volume	volume79
Issue	issue2
Publisher	Okayama University Medical School
Start Page	81
End Page	92
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2025 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	40302279
Web of Science KeyUT	001485544200003

Potential for Radiation Dose Reduction in Temporal Bone CT Imaging Using Photon-Counting Detector CT

JaLCDOI	10.18926/AMO/68645
FullText URL	79_2_075.pdf
Author	Higaki, Fumiyo\| Morimitsu, Yusuke\| Iguchi, Toshihiro\| Hwang, Sung Il\| Kitayama, Takahiro\| Takahashi, Yuka\| Uka, Mayu\| Akagi, Noriaki\| Sugaya, Akiko\| Mitsuhashi, Toshiharu\| Matsui, Yusuke\| Hiraki, Takao\|
Abstract	Temporal bone computed tomography (CT) is frequently performed for pediatric patients with ear diseases. Advances in CT technology have improved diagnostic imaging quality, but reduction of radiation exposure remains a goal. We evaluated the potential for radiation dose reduction in temporal bone CT examinations using porcine ear ossicles and a photon-counting detector CT system. Three scans of the bilateral temporal bone were performed on each of three pig cadaver heads. In each of seven successive imaging sessions, the radiation dose was reduced by an additional one-seventh of the recommended dose (RD). Two board-certified radiologists independently scored the resulting images on a scale of 1 to 5 points, where 5 represented the image quality at the RD. Images scoring ≥4.5 points were considered acceptable. Noise was assessed in a 2-cm-diameter region near the ear ossicles, and standard deviation was measured for each of the seven decrements from the RD. As the radiation dose decreased, the noise progressively increased, and visual assessment scores progressively decreased. Acceptable image scores were obtained at six-sevenths (4.9), five-sevenths (4.8), four-sevenths (4.7), and three-sevenths (4.6) of the RD. Thus, acceptable porcine temporal bone CT images were obtained with a radiation dose reduction of approximately 50%.
Keywords	computed tomography photon-counting detector computed tomography ear ossicle energy-integrating detector computed tomography
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2025-04
Volume	volume79
Issue	issue2
Publisher	Okayama University Medical School
Start Page	75
End Page	80
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2025 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	40302278
Web of Science KeyUT	001485544200002

Association between the Pretreatment Body Mass Index and Anamorelin’s Efficacy in Patients with Cancer Cachexia: A Retrospective Cohort Study

JaLCDOI	10.18926/AMO/68644
FullText URL	79_2_065.pdf
Author	Maki, Masatoshi\| Takada, Ryo\| Ishigo, Tomoyuki\| Fujiwara, Miki\| Takahashi, Yoko\| Otsuka, Shinya\| Tamura, Koji\| Hamaoka, Terutaka\|
Abstract	Anamorelin (ANAM) is used to treat cancer-associated cachexia, a syndrome involving muscle loss and anorexia. The timing of the initiation of ANAM treatment is crucial to its efficacy. Although the body mass index (BMI) is a diagnostic criterion for cancer cachexia, no studies have explored its association with ANAM efficacy. We conducted a single-center, retrospective cohort study to investigate the association between the pre-treatment BMI and ANAM efficacy in patients with cancer-associated cachexia (n=47). The ANAM treatment was considered effective if the patient’s appetite improved within 30 days of treatment initiation. We calculated a BMI cutoff value (19.5 kg/m2) and used it to divide the patients into high- and low-BMI groups. Their background, clinical laboratory values, cancer types, and treatment lines were investigated. Twenty (42.6%) had a high BMI (≥ 19.5 kg/m2) and 27 (57.4%) had a low BMI (< 19.5 kg/m2). High BMI was significantly associated with ANAM effectiveness (odds ratio 7.86, 95% confidence interval 1.99-31.00, p=0.003). Together these results indicate that it is beneficial to initiate ANAM treatment before a patient’s BMI drops below 19.5 kg/m2. Our findings will help advance cancer cachexia treatment and serve as a reference for clinicians to predict ANAM’s efficacy.
Keywords	anamorelin cancer-associated cachexia body mass index albumin efficacy rate
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2025-04
Volume	volume79
Issue	issue2
Publisher	Okayama University Medical School
Start Page	65
End Page	73
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2025 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	40302277
Web of Science KeyUT	001485544200001

Association of emergency intensive care unit occupancy due to brain-dead organ donors with ambulance diversion

FullText URL	fulltext.pdf
Author	Yumoto, Tetsuya\| Obara, Takafumi\| Hongo, Takashi\| Nojima, Tsuyoshi\| Tsukahara, Kohei\| Hisamura, Masaki\| Nakao, Atsunori\| Yorifuji, Takashi\| Naito, Hiromichi\|
Keywords	Ambulance diversion Bed occupancy Brain death Emergency medical services Intensive care units Organ donation
Published Date	2025-04-12
Publication Title	Scientific Reports
Volume	volume15
Issue	issue1
Publisher	Nature Portfolio
Start Page	12633
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40221631
DOI	10.1038/s41598-025-97198-7
Web of Science KeyUT	001466042000027
Related Url	isVersionOf https://doi.org/10.1038/s41598-025-97198-7

Surgical protocol of robotic liver resection using a two-surgeon technique (TAKUMI-3): a technical note and initial outcomes

FullText URL	fulltext.pdf
Author	Takagi, Kosei\| Fuji, Tomokazu\| Yasui, Kazuya\| Umeda, Yuzo\| Yamada, Motohiko\| Nishiyama, Takeyoshi\| Nagai, Yasuo\| Kanehira, Noriyuki\| Fujiwara, Toshiyoshi\|
Keywords	Liver resection Robotic surgery Training Outcomes
Published Date	2025-04-07
Publication Title	World Journal of Surgical Oncology
Volume	volume23
Issue	issue1
Publisher	BMC
Start Page	124
ISSN	1477-7819
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025.
File Version	publisher
PubMed ID	40197387
DOI	10.1186/s12957-025-03785-3
Web of Science KeyUT	001464921100004
Related Url	isVersionOf https://doi.org/10.1186/s12957-025-03785-3

Effect of calcium supplementation on bone deformity and histopathological findings of skin papules in a pediatric patient with vitamin D–dependent rickets type 2A: A case report

FullText URL	fulltext.pdf
Author	Hasegawa, Kosei\| Miyake, Tomoko\| Kobashi, Mina\| Tetsunaga, Tomonori\| Ago, Yuko\| Futagawa, Natsuko\| Miyahara, Hiroyuki\| Higuchi, Yousuke\| Morizane, Shin\| Tsukahara, Hirokazu\|
Keywords	rickets receptor alopecia papules calcium
Published Date	2025
Publication Title	Clinical Pediatric Endocrinology
Volume	volume34
Issue	issue2
Publisher	Japanese Society for Pediatric Endocrinology
Start Page	131
End Page	136
ISSN	0918-5739
NCID	AA11006467
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Japanese Society for Pediatric Endocrinology
File Version	publisher
PubMed ID	40201379
DOI	10.1297/cpe.2024-0079
Web of Science KeyUT	001463211600005
Related Url	isVersionOf https://doi.org/

Clinical-level screening of sleep apnea syndrome with single-lead ECG alone is achievable using machine learning with appropriate time windows

FullText URL	fulltext.pdf
Author	Yamane, Takahiro\| Fujii, Masanori\| Morita, Mizuki\|
Keywords	Disease screening Sleep apnea syndrome (SAS) Single-lead ECG Artificial intelligence Machine learning
Published Date	2025-04-11
Publication Title	Sleep and Breathing
Volume	volume29
Issue	issue2
Publisher	Springer Science and Business Media LLC
Start Page	156
ISSN	1520-9512
NCID	AA11703981
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40214940
DOI	10.1007/s11325-025-03316-0
Web of Science KeyUT	001463756600001
Related Url	isVersionOf https://doi.org/10.1007/s11325-025-03316-0

Enterobacterial common antigen repeat-unit flippase WzxE is required for Escherichia coli growth under acidic conditions, low temperature, and high osmotic stress conditions

FullText URL	fulltext.pdf
Author	Yamaguchi, Saki\| Ishikawa, Kazuya\| Furuta, Kazuyuki\| Kaito, Chikara\|
Keywords	wzxE flippase enterobacterial common antigen low pH low temperature hyperosmotic stress
Published Date	2025-04-10
Publication Title	Applied and Environmental Microbiology
Publisher	American Society for Microbiology
ISSN	0099-2240
NCID	AA00543249
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 Yamaguchi et al.
File Version	publisher
PubMed ID	40207904
DOI	10.1128/aem.02595-24
Web of Science KeyUT	001462873400001
Related Url	isVersionOf https://doi.org/10.1128/aem.02595-24

Length Estimation of Pneumatic Artificial Muscle with Optical Fiber Sensor Using Machine Learning

FullText URL	fulltext.pdf
Author	Ni, Yilei\| Wakimoto, Shuichi\| Tian, Weihang\| Toda, Yuichiro\| Kanda, Takefumi\| Yamaguchi, Daisuke\|
Keywords	McKibben artificial muscle machine learning optical fiber motion estimation
Published Date	2025-04-01
Publication Title	Sensors
Volume	volume25
Issue	issue7
Publisher	MDPI
Start Page	2221
ISSN	1424-8220
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40218734
DOI	10.3390/s25072221
Web of Science KeyUT	001467210900001
Related Url	isVersionOf https://doi.org/10.3390/s25072221

Comparison of Midazolam and Diazepam for Sedation in Patients Undergoing Double-Balloon Endoscopic Retrograde Cholangiopancreatography: A Propensity Score-Matched Analysis

FullText URL	fulltext.pdf
Author	Fujii, Yuki\| Matsumoto, Kazuyuki\| Matsumi, Akihiro\| Miyamoto, Kazuya\| Uchida, Daisuke\| Horiguchi, Shigeru\| Tsutsumi, Koichiro\| Mitsuhashi, Toshiharu\| Otsuka, Motoyuki\|
Keywords	adverse events balloon-assisted ERCP benzodiazepine sedation
Published Date	2025-03-27
Publication Title	Journal of Clinical Medicine
Volume	volume14
Issue	issue7
Publisher	MDPI
Start Page	2287
ISSN	2077-0383
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40217737
DOI	10.3390/jcm14072287
Web of Science KeyUT	001463583200001
Related Url	isVersionOf https://doi.org/10.3390/jcm14072287

Impact of Lifestyle Changes on Body Weight Gain During Nationwide Lockdown Due to COVID-19 Pandemic

FullText URL	fulltext.pdf
Author	Nishida, Chisa\| Honda, Hiroyuki\| Otsuka, Yuki\| Hagiya, Hideharu\| Nakano, Yasuhiro\| Oguni, Kohei\| Tokumasu, Kazuki\| Sakurada, Yasue\| Obika, Mikako\| Otsuka, Fumio\|
Keywords	COVID-19 pandemic lockdown weight gain medical check-ups lifestyle
Published Date	2025-03-25
Publication Title	Journal of Clinical Medicine
Volume	volume14
Issue	issue7
Publisher	MDPI
Start Page	2242
ISSN	2077-0383
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40217694
DOI	10.3390/jcm14072242
Web of Science KeyUT	001463577200001
Related Url	isVersionOf https://doi.org/10.3390/jcm14072242

Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells

FullText URL	fulltext.pdf
Author	Asaka, Yutaro\| Masumoto, Toshio\| Uneda, Atsuhito\| Chin, Vanessa D.\| Otani, Yusuke\| Pena, Tirso\| Katayama, Haruyoshi\| Itano, Takuto\| Ando, Teruhiko\| Huang, Rongsheng\| Fujimura, Atsushi\|
Keywords	Adrenoceptors Glioma stem-like cells Differentiated glioma cells Noradrenaline Cellular plasticity
Published Date	2025-07
Publication Title	The Journal of Physiological Sciences
Volume	volume75
Issue	issue2
Publisher	Elsevier
Start Page	100016
ISSN	1880-6546
NCID	AA12129145
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Authors.
File Version	publisher
PubMed ID	40184918
DOI	10.1016/j.jphyss.2025.100016
Web of Science KeyUT	001463204900001
Related Url	isVersionOf https://doi.org/10.1016/j.jphyss.2025.100016

The association between objectively measured physical activity and home blood pressure: a population-based real-world data analysis

FullText URL	fulltext.pdf
Author	Kinuta, Minako\| Hisamatsu, Takashi\| Taniguchi, Kaori\| Fukuda, Mari\| Nakahata, Noriko\| Kanda, Hideyuki\|
Note	The version of record of this article, first published in Journal of Human Hypertension, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41371-025-01014-8\|
Published Date	2025-04-03
Publication Title	Journal of Human Hypertension
Publisher	Springer Science and Business Media LLC
ISSN	1476-5527
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40181092
DOI	10.1038/s41371-025-01014-8
Web of Science KeyUT	001458976500001
Related Url	isVersionOf https://doi.org/10.1038/s41371-025-01014-8

The potential mechanism maintaining transactive response DNA binding protein 43 kDa in the mouse stroke model

FullText URL	fulltext.pdf
Author	Bian, Yuting\| Fukui, Yusuke\| Ota-Elliott, Ricardo Satoshi\| Hu, Xinran\| Sun, Hongming\| Bian, Zhihong\| Zhai, Yun\| Yu, Haibo\| Hu, Xiao\| An, Hangping\| Liu, Hongzhi\| Morihara, Ryuta\| Ishiura, Hiroyuki\| Yamashita, Toru\|
Keywords	TDP-43 ALS RNA-binding protein Mislocalization G3BP1 HDAC6 RAD23B tMCAO
Published Date	2025-04
Publication Title	Neuroscience Research
Volume	volume213
Publisher	Elsevier BV
Start Page	128
End Page	137
ISSN	0168-0102
NCID	AA10641652
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	39889925
DOI	10.1016/j.neures.2025.01.006
Web of Science KeyUT	001456257900001
Related Url	isVersionOf https://doi.org/10.1016/j.neures.2025.01.006

Bilateral Scleritis and Neutrophilic Dermatosis With Cytogenetic Chromosomal Aberrancy Related to Pyoderma Gangrenosum: A Case Report of a 20-Year Follow-Up

FullText URL	fulltext.pdf
Author	Matsuo, Toshihiko\| Tanaka, Takehiro\| Asada, Noboru\| Obika, Mikako\| Omichi, Ryotaro\| Iwatsuki, Keiji\|
Keywords	corneal infiltration hypopyon myelodysplastic syndromes neutrophilic dermatosis peripheral keratitis pyoderma gangrenosum scleritis sweet syndrome
Published Date	2025-04-16
Publication Title	Cureus
Volume	volume17
Issue	issue4
Publisher	Springer Science and Business Media LLC
Start Page	e82348
ISSN	2168-8184
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Copyright 2025 Matsuo et al.
File Version	publisher
DOI	10.7759/cureus.82348
Related Url	isVersionOf https://doi.org/10.7759/cureus.82348

Primary chest wall sarcoma: advances in surgical management and outcomes

FullText URL	fulltext.pdf
Author	Tanaka, Shin\| Nakata, Eiji\| Ryuko, Tsuyoshi\| Itano, Takuto\| Tomioka, Yasuaki\| Shien, Kazuhiko\| Suzawa, Ken\| Miyoshi, Kentaroh\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Ozaki, Toshifumi\| Toyooka, Shinichi\|
Keywords	Primary chest wall sarcomas Chest wall resection Chondrosarcoma Robust chest wall reconstruction
Published Date	2025-04-01
Publication Title	European Journal of Orthopaedic Surgery & Traumatology
Volume	volume35
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	141
ISSN	1432-1068
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40167819
DOI	10.1007/s00590-025-04260-1
Web of Science KeyUT	001459451400002
Related Url	isVersionOf https://doi.org/10.1007/s00590-025-04260-1

Elliptic virtual structure constants and generalizations of BCOV-Zinger formula to projective Fano hypersurfaces

FullText URL	fulltext.pdf
Author	Jinzenji, Masao\| Kuwata, Ken\|
Keywords	Nonperturbative Effects String Duality Topological Field Theories Topological Strings
Published Date	2024-12-17
Publication Title	Journal of High Energy Physics
Volume	volume2024
Issue	issue12
Publisher	Springer
Start Page	135
ISSN	1029-8479
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Authors.
File Version	publisher
DOI	10.1007/JHEP12(2024)135
Web of Science KeyUT	001416946000007
Related Url	isVersionOf https://doi.org/10.1007/JHEP12(2024)135

裏表紙・英文目次

FullText URL	interdisciplinary_5_contents_e.pdf
Publication Title	Interdisciplinary Science
Published Date	2025-03-31
Volume	volume5
ISSN	2436-3227
language	Japanese
File Version	publisher

投稿規程・奥付

FullText URL	interdisciplinary_5_colophon.pdf
Publication Title	Interdisciplinary Science
Published Date	2025-03-31
Volume	volume5
ISSN	2436-3227
language	Japanese
File Version	publisher

2024年度次世代医療機器開発人材育成プログラムBIZENデバイスデザインコースの取り組み

JaLCDOI	10.18926/interdisciplinary/68626
Title Alternative	Practical BIZEN Device Design Course Activity Report in Fiscal 2024
FullText URL	interdisciplinary_5_47.pdf
Author	TSUZUKI, Tsuneaki\| UCHIDA, Daisuke\| KISHIMOTO, Toshio\| SENGOKU, Yoshinari\| KORENAGA, Toshio\| HITOBE, Yu\| YOSHIBA, Yasuyuki\| SAKURAI, Jun\|
Publication Title	Interdisciplinary Science
Published Date	2025-03-31
Volume	volume5
Start Page	47
End Page	55
ISSN	2436-3227
language	Japanese
File Version	publisher

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