Illudin Sの作用機作の解折:Illudin SのL(929)線維芽細胞の表面形態に及ぼす影響について

The effects of Illudin S (a toadstool poison) on surface structures of L(929) mouse fibroblasts were studied by scanning electron microscopy. Illudin S in a concentration of 1 ng/ml strongly inhibited cell proliferation, but had no effect on surface structures of L cells through all the cell phases. These results indicate that the biological effects of Illudin S were not manifested by changes in the cytoskeletal system, the cell ability to attach to the substrate, of the surface structures of the cell. It is suggested that the cellular sensitive sites to Illudin S are inside the cell.