On the action of some diuretica and other drugs upon the glomeruli

From the results of my experiments the conclusion may be summarized as follows. 1. Caffeine, caffeine sodio-benzoate and diuretin have dilator effect upon the glomerular capillaries and the circulation in them becomes more rapid. The quantity of blood which flows through them increases and a number of glomeruli, hitherto unobserved, become visible. On the other hand, theocin and glucose have no effect upon the glomeruli. 2. Solution of potassium acetate causes a remarkable contraction and at the same time the glomeruli till then observed, become invisible. 3. Kreatin produces a dilatation of glomerular capillaries and accordingly the circulation in them becomes more rapid and also the number of glomeruli increased. Guanidin in a solution weaker than 0.4 p. c. causes dilatation of glomerular capillaries and increase of the quantity of blood which flows through them and also it causes the increase of verocity of blood flow in the glomerular capillaries. The glomeruli, hitherto stationary, become active and the number of them increases. On the contrary, a solution stronger than 0.5 p. c. always causes contraction of glomerular capillaries and the number of glomeruli are decreased. 4. Isotonic solution (with 0.6% Ringer's solution) of NaNO(2), NaNO(3) and Na(2)HPO(4) causes a slight dilatation of glomerular capillaries and accordingly the increase of verocity of blood flow in them and of quantity of blood flowing through them are produced. But other sodium salts have no effect upon the glomeruli. All of potassium salts, on the contrary, have an opposite effect upon the glomeruli to that of sodium salts. 5. Calcium salts and magnesium salts (isotonic with 0.6% Ringer's solution) and some organic substances (m/100 in density) have a remarkable dilator effect upou the glomerular capillaries and cause the increase of verocity of blood flow in them and of quantity of blood which flows through them. Glomeruli are increased in number und are remarkably congested and swollen.

利尿劑ノ利尿作用ハ絲毬體ニ於ケル濾過作用ヲ亢進スルカ細尿管ノ吸收ヲ抑制スルカ或ハ此兩者ヲ兼ヌルニ在リ,而シテ血管毬(絲毬體)ノ濾過ラ亢進スルモノハ腎動脉系ノ血壓上騰,腎臟ニ於ケル血液灌流ノ速度及ビ血液中水分ノ増大即チ水血症ナリ果シテ利尿劑ハ絲毬體ニ對シ如何ナル影響ヲ及ボスモノナルヤヲ見ント欲シ次ノ實驗ヲ行ヘリ. 古來腎臟ニ對スル藥品ノ作用ハ灌流試驗又ハOncometerヲ以テ行ハルルヲ常トスルモ此場合カカル方法ニテハ腎絲毬體ニ作用スル結果ナルヤ又腎臟動脉ニ作用スルモノナルヤヲ判別スル事難キラ以テ予ハ腎臟ヲ露出セシメ絲毬體ノ状態ヲ顯微鏡下ニ觀察シツツ豫メ造リタル硝子毛細管ヲ用ヒ各種利尿劑及ビ其他ノ藥液ヲ滴下シツツ絲毬體ノ變化ヲ觀察セリ而シテ次ノ成績ヲ得タリ.「カフエイン」安息香酸「ナトリウムカフエイン」「ヂウレチン」及ビ「クレアチン」ハ絲毬體毛細血管ヲ擴大セシメ爲ニ絲毬體内ノ血流ハ早クナリ血量ハ増加シ絲毬體ハ充血且膨大ス今迄見エザリシ絲毬體ハ出現シ活動盛トナル.之ニ反シ醋剥液ハ0.1%ニ於テ既ニ絲毬體毛細血管ヲ收縮セシメ活動セル絲毬體ハ靜止シ漸次其數ヲ減ズ.「テオチン」「葡萄糖」ハ何等ノ影響ヲ及ボサズ. Guanidinハ稀薄液ニ於テハ絲毬體毛細血管ヲ擴大シ其數ヲ増加セシムルモ濃厚液ニ於テハ毛細管ハ收縮シ絲毬體ハ消失ス,「ナトリウム」鹽類中(0.6%ノRinger氏液ト等滲透性液ニ於テ) NaNO(2), NaNO(3)及ビNa(2)HPO(4)ハ輕度ニ毛細管ヲ(絲毬ノ)擴大セシムルモ其他ハ何等ノ影響ナシ.「カリウム」鹽類ハ0.1%ノ稀薄液ニ於テ絲毬體毛細血管ヲ收縮セシメ絲毬體ハ活動ヲ停止シ遂ニ全ク消失スルニ至ル.「カルチウム」鹽類「マグネシウム」鹽類竝ニ二三有機酸ハ共ニ絲毬體毛細血管ヲ擴大セシム絲毬體ハ充血大ス靜止ノ状態ニ在リシ絲毬體ハ活動ヲ初メ其數ヲ増加ス.

原著