result 486 件
| FullText URL | J_Orthop_Sci_22_4_715.pdf fig.pdf |
|---|---|
| Author | Lu, Zhichao| Furumatsu, Takayuki| Fujii, Masataka| Maehara, Ami| Ozaki, Toshifumi| |
| Keywords | vascular endothelial growth factor (VEGF) meniscus meniscal injury hypoxia-inducible factor-1α (HIF-1α) |
| Note | This is an Accepted Manuscript of an article published by Elsevier| |
| Published Date | 2017-07 |
| Publication Title | Journal of Orthopaedic Science |
| Volume | volume22 |
| Issue | issue4 |
| Publisher | Elsevier |
| Start Page | 715 |
| End Page | 721 |
| ISSN | 0949-2658 |
| NCID | AA11052566 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 28318650 |
| DOI | 10.1016/j.jos.2017.02.006 |
| Web of Science KeyUT | 000407394700022 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jos.2017.02.006 |
| FullText URL | BBRC_485_2_261.pdf |
|---|---|
| Author | Kawaguchi, Yuka| Nariki, Hiroaki| Kawamoto, Naoko| Kanehiro, Yuichi| Miyazaki, Satoshi| Suzuki, Mari| Magari, Masaki| Tokumitsu, Hiroshi| Kanayama, Naoki| |
| Keywords | AID DT40 Gene conversion Ig SRSF1 Somatic hypermutation |
| Published Date | 2017-04 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume485 |
| Issue | issue2 |
| Publisher | Elsevier |
| Start Page | 261 |
| End Page | 266 |
| ISSN | 0006-291X |
| NCID | AA00564395 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 28235482 |
| DOI | 10.1016/j.bbrc.2017.02.097 |
| Web of Science KeyUT | 000396798300007 |
| Related Url | isVersionOf https://doi.org/10.1016/j.bbrc.2017.02.097 |
| FullText URL | K0005569_abstract_review.pdf K0005569_summary.pdf K0005569_fulltext.pdf |
|---|---|
| Author | Hiramatsu, Masafumi| |
| Published Date | 2017-06-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5569号 |
| Granted Date | 2017-06-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/55204 |
|---|---|
| FullText URL | 71_3_219.pdf |
| Author | Takakura, Hiroaki| Domae, Shohei| Ono, Toshiro| Sasaki, Akira| |
| Abstract | Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery. |
| Keywords | oral squamous cell carcinoma programmed cell death 1 ligand-1 tumor microenvironment neoadjuvant chemotherapy immunohistochemistry |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-06 |
| Volume | volume71 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 226 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28655941 |
| FullText URL | K0005559_abstract_review.pdf K0005559_fulltext.pdf |
|---|---|
| Author | Kawaguchi, Yuka| |
| Published Date | 2017-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5559号 |
| Granted Date | 2017-03-24 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005536_abstract_review.pdf K0005536_fulltext.pdf |
|---|---|
| Author | Maeda, Satoki| |
| Published Date | 2017-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5536号 |
| Granted Date | 2017-03-24 |
| Thesis Type | Doctor of Philosophy in Science |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005488 abstract_review.pdf K0005488_summary.pdf K0005488_fulltext.pdf |
|---|---|
| Author | Takakura, Hiroaki| |
| Published Date | 2017-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5488号 |
| Granted Date | 2017-03-24 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005459_abstract_review.pdf K0005459_summary.pdf K0005459_fulltext.pdf |
|---|---|
| Author | Tanaka, Takaaki| |
| Published Date | 2017-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5459号 |
| Granted Date | 2017-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Author | 岡山大学環境理工学部| |
|---|---|
| Published Date | 2017-03 |
| Publication Title | 岡山大学環境理工学部研究報告 |
| Volume | volume22 |
| Issue | issue1 |
| Content Type | Others |
| JaLCDOI | 10.18926/AMO/54806 |
|---|---|
| FullText URL | 70_6_441.pdf |
| Author | Kashihara, Naoko| Furumatsu, Takayuki| Kodama, Yuya| Tanaka, Takaaki| Ozaki, Toshifumi| |
| Abstract | Concurrent meniscal repair with anterior cruciate ligament (ACL) reconstruction has shown good clinical outcomes, but it has a considerable risk of progressing to post-traumatic osteoarthritis of the knee. Here we investigated postoperative changes in the position of the lateral meniscus (LM) and assessed the short-term clinical results after concurrent LM repair with ACL reconstruction. Twentyseven patients underwent LM repair of a peripheral longitudinal tear concomitant with ACL reconstruction. We evaluated the preoperative and postoperative values of the Lysholm score and anteroposterior instability. The length and width of the lateral tibial plateau were determined by radiographic images. The length, width, body width, extrusion, and height of the LM were measured in magnetic resonance images and compared between the preoperative and postoperative measurements. Our analysis revealed that concurrent LM repair with ACL reconstruction improved the shortterm clinical outcomes. Although the body width and height of the LM did not change, the postoperative LM extrusion and LM width were significantly increased after the surgery. The post-traumatic transposition of the LM may not be completely prevented by LM repair concomitant with ACL reconstruction. |
| Keywords | lateral meniscus meniscal extrusion meniscal repair anterior cruciate ligament reconstruction |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-12 |
| Volume | volume70 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 441 |
| End Page | 448 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28003668 |
| JaLCDOI | 10.18926/AMO/54592 |
|---|---|
| FullText URL | 70_5_345.pdf |
| Author | Maruyama, Hidehiko| Nakata, Yusei| Kanazawa, Akane| Kikkawa, Kiyoshi| |
| Abstract | We sought to clarify the survival and neurodevelopmental outcomes of very low birth weight infants (VLBWIs) and to identify risk factors for death or neurodevelopmental impairment (NDI) in VLBWIs at our hospital. The total study population was 217 infants born in 2005-2012 weighing ≤1,500 g. We compared their outcomes with those from previous reports analyzed the causes of death. Risk factors for death after discharge or NDI were evaluated by a multivariate logistic regression analysis. The incidences of death or NDI reported revealed in this study and the database of Neonatal Research Network of Japan were 25.3% and 19.6% (p＝0.039), respectively. The main causes of death before discharge were intraventricular hemorrhage, sepsis, and persistent pulmonary hypertension of the newborn. The significant risk factors for death after discharge or NDI were early gestational age (weeks) and periventricular leukomalacia (adjusted odds ratio [95% confidence interval, p-value], 0.72 [0.54-0.94, 0.017] and 6.90 [1.35-38.25, 0.021], respectively). These factors must be addressed in order to improve treatment strategies for VLBWIs. |
| Keywords | intraventricular hemorrhage periventricular leukomalacia persistent pulmonary hypertension of the newborn sepsis very low birth weight infants |
| Amo Type | Original Articles |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 345 |
| End Page | 352 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777426 |
| Web of Science KeyUT | 000388098700003 |
| Author | Ohtsuki, Takashi| Miki, Shunya| Kobayashi, Shouhei| Haraguchi, Tokuko| Nakata, Eiji| Hirakawa, Kazutaka| Sumita, Kensuke| Watanabe, Kazunori| Okazaki, Shigetoshi| |
|---|---|
| Published Date | 2015-12 |
| Publication Title | Scientific Reports |
| Volume | volume5 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/54502 |
|---|---|
| FullText URL | 70_4_269.pdf |
| Author | Takeuchi, Miharu| Maruyama, Hidehiko| Oura, Naoko| Kanazawa, Akane| Nakata, Yusei| Minami, Susumu| Kikkawa, Kiyoshi| |
| Abstract | Twin anemia-polycythemia sequence (TAPS) is a group of disorders in monochorionic twins characterized by a large intertwin hemoglobin difference without amniotic fluid discordance. Reticulocyte count is used to diagnose this condition, but little is known about the role of erythroblasts, which are the prior stage of reticulocytes. In the present case of TAPS, the 25-yr-old Japanese mother showed no signs of oligohydramnios or polyhydramnios throughout gestation. The twins were born at 36 weeks and 6 days, weighing 2,648g and 1,994g. The intertwin hemoglobin difference in umbilical cord blood was (21.1－5.0＝) 16.1g/dL and the donor twin showed signs of chronic anemia, including myocardial hypertrophy and pericardial effusion. Erythroblastosis of the donor twin was prolonged (53,088.5, 42,114.8 and 44,217.9/μL on days 0, 1 and 2, respectively). Erythroblastosis, which indicates chronic anemia, is also a good diagnostic indicator of TAPS. |
| Keywords | anastomosis erythroblast monochorionic diamniotic twin reticulocyte twin anemia-polycythemia sequence |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 269 |
| End Page | 272 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549671 |
| Web of Science KeyUT | 000384748600006 |
| Author | 岡山大学環境理工学部| |
|---|---|
| Published Date | 2016-03 |
| Publication Title | 岡山大学環境理工学部研究報告 |
| Volume | volume21 |
| Issue | issue1 |
| Content Type | Others |
| Author | Mekada, Kazuyuki| |
|---|---|
| Published Date | 2016-04 |
| Publication Title | Proceedings of Okayama Association for Laboratory Animal Science |
| Volume | volume32 |
| Content Type | Journal Article |
| FullText URL | O0004459_abstract_review.pdf O0004459_fulltext.pdf O0004459_summary.pdf |
|---|---|
| Author | Sajiki, Go| |
| Published Date | 2016-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4459号 |
| Granted Date | 2016-03-25 |
| Thesis Type | Doctor of Philosophy |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005378_abstract_review.pdf K0005378_fulltext.pdf |
|---|---|
| Author | Yano, Junko| |
| Published Date | 2016-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5378号 |
| Granted Date | 2016-03-25 |
| Thesis Type | Doctor of Philosophy in Health Sciences |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005373_abstract_review.pdf K0005373_fulltext.pdf |
|---|---|
| Author | Sakauchi, Hiroyuki| |
| Published Date | 2016-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5373号 |
| Granted Date | 2016-03-25 |
| Thesis Type | Doctor of Philosophy in Agriculture |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005370_abstract_review.pdf K0005370_fulltext.pdf |
|---|---|
| Author | Fukui, Satoshi| |
| Published Date | 2016-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5370号 |
| Granted Date | 2016-03-25 |
| Thesis Type | Doctor of Philosophy in Environmental Science |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005356_abstract_review.pdf K0005356_fulltext.pdf |
|---|---|
| Author | Akahoshi, Akiya| |
| Published Date | 2016-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5356号 |
| Granted Date | 2016-03-25 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | English |
