result 49234 件
| JaLCDOI | 10.18926/AMO/67198 |
|---|---|
| FullText URL | 78_3_237.pdf |
| Author | Muraoka, Osamu| Imai, Norio| Kuraishi, Tatsuya| Imai, Makoto| Fukuhara, Takashi| Yoshimine, Toshifumi| |
| Abstract | Fracture liaison services (FLS) have been introduced in Japan and several other countries to reduce medical complications and secondary fractures. We aimed to evaluate the effects of the implementation of an FLS approach on patient outcomes during hospitalization at our hospital and over a 2-year follow-up post-injury. This retrospective cohort study included patients ≥ 60 years admitted to our hospital for hip fragility fractures between October 1, 2016, and July 31, 2020. Patient groups were defined as those treated before (control group, n=238) and after (FLS group, n=196) establishment of the FLS protocol at our institution. The two groups were compared in terms of time to surgery, length of hospital stay, and the incidence of complications after admission, including secondary hip fracture and mortality rates. The follow-up period was 24 months. FLS focuses on early surgery within 48 h of injury and assessing osteoporosis treatment before injury to guide post-discharge anti-osteoporosis medication. FLS reduced the length of hospital stay (p<0.001) and the prevalence of complications after admission (p<0.001), particularly cardiovascular disease, and it increased adherence to anti-osteoporosis medication. These FLS effects resulted in lower secondary hip fracture and mortality rates at 12 and 24 months post-injury. FLS for fragility hip fractures can improve patient outcomes during hospitalization and over a 2-year follow-up period. |
| Keywords | fracture liaison services complications after admission secondary hip fracture mortality |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 237 |
| End Page | 243 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902211 |
| Web of Science KeyUT | 001267351000004 |
| JaLCDOI | 10.18926/AMO/67197 |
|---|---|
| FullText URL | 78_3_227.pdf |
| Author | Wada, Yudai| Ushio, Soichiro| Kitamura, Yoshihisa| Zamami, Yoshito| Sendo, Toshiaki| |
| Abstract | Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression. |
| Keywords | lipopolysaccharide zolpidem GABAA receptor K+-Cl− cotransporters |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 227 |
| End Page | 235 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902210 |
| Web of Science KeyUT | 001267351000003 |
| JaLCDOI | 10.18926/AMO/67196 |
|---|---|
| FullText URL | 78_3_215.pdf |
| Author | Akagawa, Takuya| Fukui, Ryohei| Kida, Katsuhiro| Matsuura, Ryutaro| Shimada, Makoto| Kinoshita, Mitsuhiro| Akagawa, Yoko| Goto, Sachiko| |
| Abstract | We propose a sitting position that achieves both high image quality and a reduced radiation dose in elbow joint imaging by area detector computed tomography (ADCT), and we compared it with the ‘superman’ and supine positions. The volumetric CT dose index (CTDIvol) for the sitting, superman, and supine positions were 2.7, 8.0, and 20.0 mGy and the dose length products (DLPs) were 43.4, 204.7, and 584.8 mGy • cm, respectively. In the task-based transfer function (TTF), the highest value was obtained for the sitting position in both bone and soft tissue images. The noise power spectrum (NPS) of bone images showed that the superman position had the lowest value up to approx. 1.1 cycles/mm or lower, whereas the sitting position had the lowest value when the NPS was greater than approx. 1.1 cycles/mm. The overall image quality in an observer study resulted in the following median Likert scores for Readers 1 and 2: 5.0 and 5.0 for the sitting position, 4.0 and 3.5 for the superman position, and 4.0 and 2.0 for the supine position. These results indicate that our proposed sitting position with ADCT of the elbow joint can provide superior image quality and allow lower radiation doses compared to the superman and supine positions. |
| Keywords | area detector computed tomography elbow joint sitting position dose reduction image quality assessment |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 215 |
| End Page | 225 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902209 |
| Web of Science KeyUT | 001267351000002 |
| JaLCDOI | 10.18926/AMO/67195 |
|---|---|
| FullText URL | 78_3_205.pdf |
| Author | Hagiya, Hideharu| |
| Abstract | The global pandemic of COVID-19 has underscored the significance of establishing and sustaining a practical and efficient infection control system for the benefit and welfare of society. Infectious disease (ID) specialists are expected to take on leadership roles in enhancing organizational infrastructures for infection prevention and control (IPC) at the hospital, community, and national levels. However, due to an absolute shortage and an uneven distribution, many core hospitals currently lack the ID specialists. Given the escalating global risk of emerging and re-emerging infectious diseases as well as antimicrobial resistance pathogens, the education and training of ID specialists constitutes an imperative concern. As demonstrated by historical changes in the healthcare reimbursement system, the establishment and enhancement of IPC measures is pivotal to ensuring medical safety. The existing structure of academic society-driven certification and training initiatives for ID specialists, contingent upon the discretionary decisions of individual physicians, possesses both quantitative and qualitative shortcomings. In this article, I first address the present situations and challenges related to ID specialists and then introduce my idea of securing ID specialists based on the new concepts and platforms; (i) ID Specialists as National Credentials, (ii) Establishment of the Department of Infectious Diseases in Medical and Graduate Schools, (iii) Endowed ID Educative Courses Funded by Local Government and Pharmaceutical Companies, and (iv) Recruitment of Young Physicians Engaged in Healthcare Services in Remote Areas. As clarified by the COVID-19 pandemic, ID specialists play a crucial role in safeguarding public health. Hopefully, this article will advance the discussion and organizational reform for the education and training of ID specialists. |
| Keywords | antimicrobial resistance emerging infectious diseases infection prevention and control medical education silent pandemic |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 205 |
| End Page | 213 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902208 |
| Web of Science KeyUT | 001267351000001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Swe, Hnin‐Wint‐Wint| Fujisawa, Masayoshi| Ohara, Toshiaki| Komatsubara, Yu| Yoshimura, Teizo| Shien, Tadahiko| Matsukawa, Akihiro| |
| Keywords | angiogenesis blood vessels breast cancer CD31 antigen immunohistochemistry microvessel density survival analysis |
| Published Date | 2024-05-31 |
| Publication Title | Pathology International |
| Volume | volume74 |
| Issue | issue7 |
| Publisher | Wiley |
| Start Page | 394 |
| End Page | 407 |
| ISSN | 1320-5463 |
| NCID | AA10984364 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 38818885 |
| DOI | 10.1111/pin.13442 |
| Web of Science KeyUT | 001235649700001 |
| Related Url | isVersionOf https://doi.org/10.1111/pin.13442 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ngo, An Thuy| Mori, Yasushi| Bui, Long Thanh| |
| Keywords | Soil amendments water -saving polymers soil moisture improvement mean weight diameter irrigation water |
| Published Date | 2024-08 |
| Publication Title | Environmental Technology & Innovation |
| Volume | volume35 |
| Publisher | Elsevier |
| Start Page | 103650 |
| ISSN | 2352-1864 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| DOI | 10.1016/j.eti.2024.103650 |
| Web of Science KeyUT | 001238871900001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.eti.2024.103650 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takamura, Hiroyoshi| Sugitani, Yuki| Morishita, Ryohei| Yorisue, Takefumi| Kadota, Isao| |
| Published Date | 2024 |
| Publication Title | Organic & Biomolecular Chemistry |
| Volume | volume22 |
| Issue | issue28 |
| Publisher | Royal Society of Chemistry (RSC) |
| Start Page | 5739 |
| End Page | 5747 |
| ISSN | 1477-0520 |
| NCID | AA1168650X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Royal Society of Chemistry 2024 |
| File Version | publisher |
| PubMed ID | 38828517 |
| DOI | 10.1039/d4ob00698d |
| Web of Science KeyUT | 001237473000001 |
| Related Url | isVersionOf https://doi.org/10.1039/d4ob00698d |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ueno, Asami| Onishi, Yasuhiro| Mise, Koki| Yamaguchi, Satoshi| Kanno, Ayaka| Nojima, Ichiro| Higuchi, Chigusa| Uchida, Haruhito A.| Shikata, Kenichi| Miyamoto, Satoshi| Nakatsuka, Atsuko| Eguchi, Jun| Hida, Kazuyuki| Katayama, Akihiro| Watanabe, Mayu| Nakato, Tatsuaki| Tone, Atsuhito| Teshigawara, Sanae| Matsuoka, Takashi| Kamei, Shinji| Murakami, Kazutoshi| Shimizu, Ikki| Miyashita, Katsuhito| Ando, Shinichiro| Nunoue, Tomokazu| Wada, Jun| |
| Published Date | 2024-05 |
| Publication Title | BMJ Open Diabetes Research and Care |
| Volume | volume12 |
| Issue | issue3 |
| Publisher | BMJ Publishing Group |
| Start Page | e004237 |
| ISSN | 2052-4897 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Author(s) (or their employer(s)) 2024. |
| File Version | publisher |
| PubMed ID | 38816205 |
| DOI | 10.1136/bmjdrc-2024-004237 |
| Web of Science KeyUT | 001236385500001 |
| Related Url | isVersionOf https://doi.org/10.1136/bmjdrc-2024-004237 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Vo, Quan Duy| Saito, Yukihiro| Ida, Toshihiro| Nakamura, Kazufumi| Yuasa, Shinsuke| |
| Published Date | 2024-05-21 |
| Publication Title | PLoS ONE |
| Volume | volume19 |
| Issue | issue5 |
| Publisher | Public Library of Science |
| Start Page | e0302537 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Vo et al. |
| File Version | publisher |
| PubMed ID | 38771829 |
| DOI | 10.1371/journal.pone.0302537 |
| Web of Science KeyUT | 001228816000059 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0302537 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mao, Zhiyuan| Li, Xingyue| Li, Zhenhua| Shen, Liangliang| Li, Xiaoyi| Yang, Yanyan| Wang, Wenda| Kuang, Tingyun| Shen, Jian-Ren| Han, Guangye| |
| Note | The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-024-48878-x| |
| Published Date | 2024-05-28 |
| Publication Title | Nature Communications |
| Volume | volume15 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 4535 |
| ISSN | 2041-1723 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38806516 |
| DOI | 10.1038/s41467-024-48878-x |
| Web of Science KeyUT | 001234660500031 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-024-48878-x |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shibata, Masashi| Otsuka, Yuki| Hagiya, Hideharu| Koyama, Toshihiro| Kashiwagi, Hideyuki| Otsuka, Fumio| |
| Published Date | 2024-02-28 |
| Publication Title | PLoS ONE |
| Volume | volume19 |
| Issue | issue2 |
| Publisher | Public Library of Science |
| Start Page | e0299700 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Shibata et al. |
| File Version | publisher |
| PubMed ID | 38416759 |
| DOI | 10.1371/journal.pone.0299700 |
| Web of Science KeyUT | 001181689500043 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0299700 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Zhang, Nan| An, Weichao| Yu, Yinghua| Wu, Jinglong| Yang, Jiajia| |
| Keywords | response inhibition ratio go/no-go task ERP NoGo-P3 component |
| Published Date | 2024-04-24 |
| Publication Title | Brain Sciences |
| Volume | volume14 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 414 |
| ISSN | 2076-3425 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38790393 |
| DOI | 10.3390/brainsci14050414 |
| Web of Science KeyUT | 001232265800001 |
| Related Url | isVersionOf https://doi.org/10.3390/brainsci14050414 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamamoto, Koichiro| Oguni, Kohei| Otsuka, Fumio| |
| Keywords | adrenal cyst adrenal incidentaloma adrenal tumor hypertension |
| Published Date | 2024-05-24 |
| Publication Title | Clinical Case Reports |
| Volume | volume12 |
| Issue | issue6 |
| Publisher | Wiley |
| Start Page | e8914 |
| ISSN | 2050-0904 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 38799545 |
| DOI | 10.1002/ccr3.8914 |
| Web of Science KeyUT | 001230589300001 |
| Related Url | isVersionOf https://doi.org/10.1002/ccr3.8914 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sakurada, Takato| Chikada, Yuta| Miyahara, Ryo| Taniguchi, Yosuke| |
| Keywords | 8-oxo-2 '-deoxyguanosine single nucleotide elongation reaction artificial nucleoside triphosphate 2 '-deoxycytidine derivatives |
| Published Date | 2024-05-11 |
| Publication Title | Molecules |
| Volume | volume29 |
| Issue | issue10 |
| Publisher | MDPI |
| Start Page | 2270 |
| ISSN | 1420-3049 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38792131 |
| DOI | 10.3390/molecules29102270 |
| Web of Science KeyUT | 001231259100001 |
| Related Url | isVersionOf https://doi.org/10.3390/molecules29102270 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sue, Masahiko| Takeuchi, Yasuto| Hirata, Shoichiro| Takaki, Akinobu| Otsuka, Motoyuki| |
| Keywords | immune-related adverse events serum albumin real-world practice |
| Published Date | 2024-05-09 |
| Publication Title | Cancers |
| Volume | volume16 |
| Issue | issue10 |
| Publisher | MDPI |
| Start Page | 1811 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38791890 |
| DOI | 10.3390/cancers16101811 |
| Web of Science KeyUT | 001233134000001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers16101811 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mu, Xindi| Ono, Mitsuaki| Nguyen, Ha Thi Thu| Wang, Ziyi| Zhao, Kun| Komori, Taishi| Yonezawa, Tomoko| Kuboki, Takuo| Oohashi, Toshitaka| |
| Keywords | cell differentiation epithelia growth factor(s) bioinformatics extracellular matrix (ECM) mucocutaneous disorders |
| Published Date | 2024-05-09 |
| Publication Title | Cells |
| Volume | volume13 |
| Issue | issue10 |
| Publisher | MDPI |
| Start Page | 807 |
| ISSN | 2073-4409 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38786031 |
| DOI | 10.3390/cells13100807 |
| Web of Science KeyUT | 001232270600001 |
| Related Url | isVersionOf https://doi.org/10.3390/cells13100807 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Moriwake, Kazuya| Noma, Kazuhiro| Kawasaki, Kento| Matsumoto, Tasuku| Hashimoto, Masashi| Kato, Takuya| Maeda, Naoaki| Tanabe, Shunsuke| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi| |
| Keywords | Reconstruction with the free jejunum flap Subtotal esophagectomy After pancreatoduodenectomy |
| Note | The version of record of this article, first published in Surgical Case Reports, is available online at Publisher’s website: http://dx.doi.org/10.1186/s40792-024-01919-5| |
| Published Date | 2024-05-22 |
| Publication Title | Surgical Case Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 128 |
| ISSN | 2198-7793 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 38775882 |
| DOI | 10.1186/s40792-024-01919-5 |
| Web of Science KeyUT | 001229350000001 |
| Related Url | isVersionOf https://doi.org/10.1186/s40792-024-01919-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyoshi, Shin-Ichi| Kurata, Megumi| Hirose, Riho| Yoshikawa, Masaya| Liang, Yong| Yamagishi, Yosuke| Mizuno, Tamaki| |
| Keywords | Vibrio cholerae Vibrio vulnificus genotype LAMP water temperature |
| Published Date | 2024-04-27 |
| Publication Title | Microorganisms |
| Volume | volume12 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 877 |
| ISSN | 2076-2607 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38792707 |
| DOI | 10.3390/microorganisms12050877 |
| Web of Science KeyUT | 001231571500001 |
| Related Url | isVersionOf https://doi.org/10.3390/microorganisms12050877 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Maruyama, Takayuki| Ekuni, Daisuke| Yokoi, Aya| Nagasaki, Junichiro| Sawada, Nanami| Morita, Manabu| |
| Keywords | halitosis antimicrobial photodynamic therapy prevention randomized clinical trial |
| Published Date | 2024-05-09 |
| Publication Title | Healthcare |
| Volume | volume12 |
| Issue | issue10 |
| Publisher | MDPI |
| Start Page | 980 |
| ISSN | 2227-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38786391 |
| DOI | 10.3390/healthcare12100980 |
| Web of Science KeyUT | 001232995300001 |
| Related Url | isVersionOf https://doi.org/10.3390/healthcare12100980 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kunisada, Toshiyuki| Nakata, Eiji| Fujiwara, Tomohiro| Hata, Toshiaki| Sato, Kohei| Katayama, Haruyoshi| Kondo, Ayana| Ozaki, Toshifumi| |
| Keywords | hydroxyapatite bone tumor orthopedic surgery unidirectional porous hydroxyapatite bone graft |
| Published Date | 2024-05-15 |
| Publication Title | Biomimetics |
| Volume | volume9 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 294 |
| ISSN | 2313-7673 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38786504 |
| DOI | 10.3390/biomimetics9050294 |
| Web of Science KeyUT | 001232206900001 |
| Related Url | isVersionOf https://doi.org/10.3390/biomimetics9050294 |