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ID 30468
JaLCDOI
FullText URL
Author
Gomita, Yutaka
Furuno, Katsushi
Araki, Yasunori
Abstract

The plasma level of isosorbide dinitrate intraperitoneally administered to rats stressed by foot-shock was almost the same as that in non-stressed control rats. However, levels of its metabolites, 5-isosorbide mononitrate and 2-isosorbide mononitrate, were lower in stressed rats than in non-stressed rats, suggesting that stress may influence the metabolism and/or excretion of the metabolites.

Keywords
isosorbird dinitrate
pharmacokinetics
emotional stress
rats
Amo Type
Article
Publication Title
Acta Medica Okayama
Published Date
1990-02
Volume
volume44
Issue
issue1
Publisher
Okayama University Medical School
Start Page
51
End Page
53
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
English
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT