寄生虫アレルギーに関する研究 第3編 蛔虫アレルギーによる瘢痕性腸間膜炎に関する実験的研究

With the use of the eggs of pig ascaris and the emulsion of pig ascaris, guinea pigs were sensitized and infected, and after either resensitizing or reinfecting these animals, the intracutaneous and the intestianl reactions as well as the macroscopical and the histologic findings were studied. The following are the experimental results. 1) Both the intracutaneous and the intestinal reactions proved to be positive; and the reactions were stronger in the cases infected after sensitization with emulsion of ascaris than in those infected with ascaris. 2) In both the reinfected and resensitized cases, on the second to fourth day macroscopically the hyperemia and cloudiness of the mesentery were the main changes and microscopically hemorrhages, hyperemia and the infiltrations of eosinophils, monocytes and lymphocytes could be seen in the mesentery. On the tenth day they showed cloudiness and swelling and histologically the cell proliferation of serous membrane and edema as well as hypertrophy of the wall of arterioles could be recognized. The reinfected cases revealed granulative inflammations and the infiltrations of giant cells, monocytes and eosinophils. On the twentieth day in some the fusion of mesentery and grayish white scar formation could be recognized and string-like proliferation of connective tissue as well as hyaline degeneration were detected. 3) From these findings it is believed that ascaris allergy is one of the causes of mesenteritis cicatricans.