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Author Ueda, Ayaka| Shinoda-Ito, Yuki| Takeuchi-Hatanaka, Kazu| Ito, Takashi| Ono, Shintaro| Hirai, Kimito| Omori, Kazuhiro| Yamamoto, Tadashi| Takashiba, Shogo|
Keywords Dental education Infection control Fluorescent dye Adenosine triphosphate Lactobacillus
Published Date 2025-02-08
Publication Title BMC Oral Health
Volume volume25
Issue issue1
Publisher BMC
Start Page 199
ISSN 1472-6831
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025.
File Version publisher
PubMed ID 39923078
DOI 10.1186/s12903-025-05584-4
Web of Science KeyUT 001416641300005
Related Url isVersionOf https://doi.org/10.1186/s12903-025-05584-4
FullText URL fulltext.pdf
Author Ooba, Hikaru| Maki, Jota| Masuyama, Hisashi|
Keywords Perinatal mental disorders Voice analysis Machine learning Screening Pregnant women
Published Date 2025-02-08
Publication Title Discover Mental Health
Volume volume5
Issue issue1
Publisher Springer Nature
Start Page 12
ISSN 2731-4383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 39920468
DOI 10.1007/s44192-025-00138-0
Web of Science KeyUT 001415532800001
Related Url isVersionOf https://doi.org/10.1007/s44192-025-00138-0
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Author Yagi, Tomohiko| Kagawa, Shunsuke| Nogi, Shohei| Taniguchi, Atsuki| Yoshimoto, Masashi| Suemori, Kanto| Nagai, Yasuo| Fujita, Shuto| Kuroda, Shinji| Kikuchi, Satoru| Kakiuchi, Yoshihiko| Teraishi, Fuminori| Takagi, Kosei| Ohara, Toshiaki| Tazawa, Hiroshi| Fujiwara, Toshiyoshi|
Keywords Cancer-associated fibroblasts Neutrophil Anti-fibrotic agent Pirfenidone
Published Date 2025-02-04
Publication Title Cancer Immunology, Immunotherapy
Volume volume74
Issue issue3
Publisher Springer
Start Page 96
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 39904796
DOI 10.1007/s00262-025-03946-z
Web of Science KeyUT 001413348800005
Related Url isVersionOf https://doi.org/10.1007/s00262-025-03946-z
JaLCDOI 10.18926/AMO/68356
FullText URL 79_1_031.pdf
Author Maeda, Shigeru| Pimkhaokham, Atiphan| Yoshida, Michihiro| Hosoi, Hiroki| Ohshima, Ayako| Kurisu, Ryoko| Utsumi, Nozomi| Higuchi, Hitoshi| Miyawaki, Takuya|
Abstract We retrospectively analyzed the safety of the use of articaine, an amide-type local anesthetic, in Japanese dental patients (n=300) treated in Thailand in 2015-2017. The dosage, adverse events (AEs) caused by local anesthesia, and treatment efficacy were examined. Articaine, which is safe for patients with liver impairments due to its unique metabolism, has not been thoroughly tested in Japan for doses above 5.1 mL. Eighty of the present patients had undergone root canal treatment (RCT), 71 underwent tooth extraction, and 149 underwent implant-related surgery. More than three articaine cartridges were used in 41 patients, and no AEs occurred in these cases. The only AE occurred in a 52-year-old woman who was treated with three cartridges and presented with what appeared to be hyperventilation syndrome; she later recovered and received her dental treatment as scheduled. Most treatments were completed with three or fewer cartridges, suggesting that this number is generally sufficient. Our findings, particularly the low AE risk even with doses exceeding three cartridges, support the potential applicability of the overseas recommended maximum dose of articaine (7 mg/kg) in Japanese patients. This conclusion is significant for advancing dental anesthetic practices and ensuring patient safety and treatment efficacy in Japan.
Keywords dental anesthesia local anesthesia drug-related side effect adverse reaction
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-02
Volume volume79
Issue issue1
Publisher Okayama University Medical School
Start Page 31
End Page 37
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40012157
Web of Science KeyUT 001440463800004
JaLCDOI 10.18926/AMO/68355
FullText URL 79_1_021.pdf
Author Yamamoto, Yasuhiro| Haraguchi, Takafumi| Matsuda, Kaori| Okazaki, Yoshio| Kimoto, Shin| Tanji, Nozomu| Matsumoto, Atsushi| Kobayashi, Yasuyuki| Mimura, Hidefumi| Hiraki, Takao|
Abstract We developed a machine learning model for predicting prostate cancer (PCa) grades using radiomic features of magnetic resonance imaging. 112 patients diagnosed with PCa based on prostate biopsy between January 2014 and December 2021 were evaluated. Logistic regression was used to construct two prediction models, one using radiomic features and prostate-specific antigen (PSA) values (Radiomics model) and the other Prostate Imaging-Reporting and Data System (PI-RADS) scores and PSA values (PI-RADS model), to differentiate high-grade (Gleason score [GS] ≥ 8) from intermediate or low-grade (GS < 8) PCa. Five imaging features were selected for the Radiomics model using the Gini coefficient. Model performance was evaluated using AUC, sensitivity, and specificity. The models were compared by leave-one-out cross-validation with Ridge regularization. Furthermore, the Radiomics model was evaluated using the holdout method and represented by a nomogram. The AUC of the Radiomics and PI-RADS models differed significantly (0.799, 95% CI: 0.712-0.869; and 0.710, 95% CI: 0.617-0.792, respectively). Using holdout method, the Radiomics model yielded AUC of 0.778 (95% CI: 0.552-0.925), sensitivity of 0.769, and specificity of 0.778. It outperformed the PI-RADS model and could be useful in predicting PCa grades, potentially aiding in determining appropriate treatment approaches in PCa patients.
Keywords prostate cancer machine learning prostate Imaging-Reporting and Data System radiomics Gleason score
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-02
Volume volume79
Issue issue1
Publisher Okayama University Medical School
Start Page 21
End Page 30
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40012156
Web of Science KeyUT 001440463800003
JaLCDOI 10.18926/AMO/68354
FullText URL 79_1_009.pdf
Author Ikeya, Nanami| Okita, Atsushi| Hashida, Shinsuke| Yamamoto, Sumiharu| Ikeda, Hirokuni| Tsukuda, Kazunori| Toyooka, Shinichi|
Abstract Muscle loss negatively affects gastrectomy prognosis. However, muscle loss is recognized as a systemic change, and individual muscle function is often overlooked. We investigated changes in the muscle volume of individual muscles after gastrectomy to identify clues for prognostic factors and optimal rehabilitation programs. Patients who underwent R0 gastrectomy for Stage I gastric cancer at our hospital from 2015 to 2021 were retrospectively selected to minimize the effects of malignancy and chemotherapy. Trunk muscle volume was measured by computed tomography to analyze body composition changes. Statistical analysis was performed to identify risk factors related to body composition changes. We compared the preoperative and 6-month postoperative conditions of 59 patients after gastrectomy. There was no difference in the psoas major muscle, a conventional surrogate marker of sarcopenia. There were significant decreases in the erector spinae (p=0.01) and lateral abdominal (p=0.01) muscles, and a significant increase in the rectus abdominis muscle (p=0.02). No significant correlation was found between these muscle changes and nutritional status. Body composition imbalance may serve as a new indicator of the general condition of patients after gastrectomy. Rehabilitation to correct this imbalance may improve prognosis after gastrectomy.
Keywords sarcopenia skeletal muscle gastric cancer gastrectomy erector spinae muscle
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-02
Volume volume79
Issue issue1
Publisher Okayama University Medical School
Start Page 9
End Page 19
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40012155
Web of Science KeyUT 001440463800002
JaLCDOI 10.18926/AMO/68353
FullText URL 79_1_001.pdf
Author Thiha, Moe| Hikita, Takao| Nakayama, Masanori|
Abstract Endothelial cell polarity is fundamental to the organization and function of blood vessels, influencing processes such as angiogenesis, vascular stability, and response to shear stress. This review elaborates on the molecular mechanisms that regulate endothelial cell polarity, focusing on key players like the PAR polarity complex and Rho family GTPases. These pathways coordinate the front–rear, apical–basal and planar polarity of endothelial cells, which are essential for the proper formation and maintenance of vascular structures. In health, endothelial polarity ensures not only the orderly development of blood vessels, with tip cells adopting distinct polarities during angiogenesis, but also ensures proper vascular integrity and function. In disease states, however, disruptions in polarity contribute to pathologies such as coronary artery disease, where altered planar polarity exacerbates atherosclerosis, and cancer, where disrupted polarity in tumor vasculature leads to abnormal vessel growth and function. Understanding cell polarity and its disruption is fundamental not only to comprehending how cells interact with their microenvironment and organize themselves into complex, organ-specific tissues but also to developing novel, targeted, and therapeutic strategies for a range of diseases, from cardiovascular disorders to malignancies, ultimately improving patient outcomes.
Keywords blood vessel endothelial cell cell polarity atherosclerosis cancer
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2025-02
Volume volume79
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 7
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40012154
Web of Science KeyUT 001440463800001
Author Arakawa, Jinta| Yabuki, Ryo| Uemori, Takeshi| Ito, Masato| Yaguchi, Kenichi|
Keywords Small fatigue crack Crystal orientation CP-FEM EBSD
Note © 2025 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jan. 2027.|
Published Date 2025-03-15
Publication Title Engineering Failure Analysis
Volume volume170
Publisher Elsevier BV
Start Page 109242
ISSN 1350-6307
NCID AA11028313
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Elsevier Ltd.
File Version author
DOI 10.1016/j.engfailanal.2024.109242
Web of Science KeyUT 001405677600001
Related Url isVersionOf https://doi.org/10.1016/j.engfailanal.2024.109242
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Author Matsumoto, Naomi| Mitsui, Takashi| Tamai, Kei| Hirota, Tomoya| Masuyama, Hisashi| Yorifuji, Takashi|
Keywords Cesarean delivery Delivery methods Long-term outcome Child development Outcome-wide approach
Published Date 2025-01-20
Publication Title Scientific Reports
Volume volume15
Issue issue1
Publisher Nature Portfolio
Start Page 2485
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 39833288
DOI 10.1038/s41598-025-87043-2
Web of Science KeyUT 001402008500024
Related Url isVersionOf https://doi.org/10.1038/s41598-025-87043-2
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Author Yamada, Yuto| Fujiwara, Masaki| Nakaya, Naoki| Otsuki, Koji| Shimazu, Taichi| Fujimori, Maiko| Hinotsu, Shiro| Nagoshi, Kiwamu| Uchitomi, Yosuke| Inagaki, Masatoshi|
Keywords bipolar disorder cancer screening COVID-19 healthcare disparities schizophrenia
Published Date 2025-02-02
Publication Title Psychiatry and Clinical Neurosciences Reports
Volume volume4
Issue issue1
Publisher Wiley
Start Page e70062
ISSN 2769-2558
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 39902101
DOI 10.1002/pcn5.70062
Web of Science KeyUT 001410823100001
Related Url isVersionOf https://doi.org/10.1002/pcn5.70062
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Author Kato, Koji| Nakajima, Yoshiki| Xing, Jian| Kumazawa, Minoru| Ogawa, Haruya| Shen, Jian-Ren| Ifuku, Kentaro| Nagao, Ryo|
Published Date 2024-10-31
Publication Title eLife
Volume volume13
Publisher eLife Sciences Publications
Start Page RP99858
ISSN 2050-084X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Kato, Nakajima, Xing et al.
File Version publisher
PubMed ID 39480899
DOI 10.7554/eLife.99858
Web of Science KeyUT 001394525300001
Related Url isVersionOf https://doi.org/10.7554/eLife.99858
Title Alternative Elucidation of plant-bacterial pathogen interactions for the control of bacterial blight on cruciferous crops
FullText URL srfa_114_021_025.pdf
Author Sakata, Nanami|
Abstract  Pseudomonas cannabina pv. alisalensis (Pcal), the causative agent of bacterial blight on cruciferous crops, is an economically important pathogen worldwide. We have conducted several studies on the interactions between plants and pathogenic bacteria to develop effective control strategies for this disease. Using forward and reverse genetics, we identified several virulence factors, including the type III secretion system, membrane transporters, transcriptional factors, and amino acid metabolism. Additionally, we emphasized the role of coronatine, a toxin produced by Pcal, which promotes stomatal reopening and suppresses salicylic acid accumulation in plants. We also examined plant defense mechanisms activated by one of the plant defense activators, acibenzolar-S-methyl (ASM). ASM enhanced stomatal-based defense, resulting in reduction of bacterial entry and disease development. Moreover, we explored innovative control strategies for bacterial disease and demonstrated that amino acids and cellulose nanofiber are efficient and environmentally friendly control strategies. These studies advance our understanding of plant-pathogen dynamics and offer promising, sustainable approaches for managing bacterial blight disease in cruciferous crops.
Keywords Plant pathogenic bacteria Pseudomonas Cruciferous Plant protection Stomata
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2025-02-01
Volume volume114
Start Page 21
End Page 25
ISSN 2186-7755
language Japanese
File Version publisher
Title Alternative Uncovering the role of arcuate kisspeptin neurons as a source of the gonadotropin-releasing hormone pulse generator using gene-modified rats
FullText URL srfa_114_011_020.pdf
Author Nagae, Mayuko| Uenoyama, Yoshihisa|
Abstract  Strategies for increasing reproductive performance are needed for domestic animals because for example the conception (pregnancy) rate has decreased in dairy cows around the world. Reproductive function is controlled by hormones released by the hypothalamus-pituitary-gonadal axis in mammals, including domestic animals. Of those hormones, tonic (pulsatile) gonadotropin-releasing hormone (GnRH) release is fundamentally important for gonadotropin release and gonadal activity. Therefore, uncovering the mechanism controlling GnRH pulses, that is GnRH pulse generator, is essential to improve reproductive technologies for domestic animals. The present review is focused on the indispensable role of arcuate nucleus (ARC) kisspeptin neurons (also known as KNDy neurons) as the GnRH pulse generator in mammals. First, we give a brief overview of studies on hypothalamic kisspeptin neurons throughout the past two decades. Second, we review studies that have provided direct evidence that ARC kisspeptin neurons serve as the GnRH pulse generator, with a special focus on our gene-modified rat models. Finally, we discuss the mechanism underlying GnRH pulse generation. The knowledge obtained from gene-modified rat models should be clinically important and could be adapted to new tools to improve reproductive performance in livestock by stimulating GnRH/gonadotropin pulses.
Keywords gene-modified rats GnRH kisspeptin LH pulse generator
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2025-02-01
Volume volume114
Start Page 11
End Page 20
ISSN 2186-7755
language English
File Version publisher
FullText URL srfa_114_001_010.pdf
Author Saitoh, Kuniyuki| Murakami, Tomohiro| Nakamura, Yumi| Nishibori, Misa| Takagoshi, Yuki| Hirai, Yoshihiko|
Abstract  Eleven crops were cultivated: maize, sunflower, soybean, groundnuts, sesame, kenaf, barley, wheat, rice, potato, and sweet potato. The crop growth rate (CGR) and specific dark-respiration rate (Rs) were measured, and growth efficiency GE =CGR/(CGR+R) (R, respiratory loss) was calculated. In each crop, whole-plant Rs reached a maximum in the earlier stages of growth, declined rapidly until the early reproductive growth, and remained almost constant during the ripening period. The Rs of leaves was higher than that of stems during the reproductive growth period, except for maize and potato. The Rs of storage organs was highest in the earlier stages, followed by a rapid decline to similar or lower values than those of leaves and stems during the ripening period. The GE in whole plant was higher than 60% in wheat, maize, barley, sunflower, rice, kenaf, sesame, but lower in soybean, sweet potato and groundnuts, and lowest in potato, which was affected by the higher respiratory loss. The GE in whole plant during the reproductive growth period was significantly lower, which we attributed to increased maintenance costs due to the increase of non-assimilative organs, and decrease in the dry weight of vegetative organs. A positive correlation was observed between the carbohydrate content of storage organs and GE, indicating that a crop with higher carbohydrate content in storage organs tended to have a higher GE. Crops with higher protein and crude fat content in storage organs tended to have lower GE. The GE over the growing season was low for kenaf, a fiber crop which contains high molecular weight compounds such as lignin and cellulose, and lower for sesame, groundnuts, and soybean, which contain high oil and protein and have high respiration costs for the synthesis of storage materials, suggesting that these higher respiration costs are related to lower dry matter production and hence lower yields.
Keywords Cereal crops Oil crops Crop growth rate Dark-respiration Growth efficiency Leguminous crops Nutrients composition Respiratory loss Root and tuber crops
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Published Date 2025-02-01
Volume volume114
Start Page 1
End Page 10
ISSN 2186-7755
language English
File Version publisher
FullText URL fulltext.pdf
Author Seki, Aiko| Kajiwara, Koichiro| Teramachi, Jumpei| Egusa, Masahiko| Miyawaki, Takuya| Sawa, Yoshihiko|
Keywords F. Nucleatum Diabetic exacerbation Diabetic nephropathy SGLT2
Published Date 2025-01-24
Publication Title BMC Nephrology
Volume volume26
Issue issue1
Publisher BMC
Start Page 38
ISSN 1471-2369
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025.
File Version publisher
PubMed ID 39856606
DOI 10.1186/s12882-025-03965-z
Web of Science KeyUT 001406224900002
Related Url isVersionOf https://doi.org/10.1186/s12882-025-03965-z
FullText URL fulltext.pdf
Author Gao, Binyue| Yu, Yinghua| Ejima, Yoshimichi| Wu, Jinglong| Yang, Jiajia|
Keywords pleasantness softness touch strategy task context psychophysics
Published Date 2025-01-13
Publication Title Behavioral Sciences
Volume volume15
Issue issue1
Publisher MDPI
Start Page 63
ISSN 2076-328X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 by the authors.
File Version publisher
PubMed ID 39851867
DOI 10.3390/bs15010063
Web of Science KeyUT 001404542900001
Related Url isVersionOf https://doi.org/10.3390/bs15010063
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Author Morita, Kosei| Mitsuda, Yuta| Yoshida, Sota| Kiwa, Toshihiko| Wang, Jin|
Keywords terahertz chemical microscope surface potential DNA aptamer-neurochemical complexes membrane-ion interactions SOS substrate artificial cerebrospinal fluid
Published Date 2025-01-13
Publication Title Biosensors
Volume volume15
Issue issue1
Publisher MDPI
Start Page 46
ISSN 2079-6374
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 by the authors.
File Version publisher
PubMed ID 39852097
DOI 10.3390/bios15010046
Web of Science KeyUT 001404546800001
Related Url isVersionOf https://doi.org/10.3390/bios15010046
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Author Nakamura, Kazufumi| Akagi, Satoshi| Ejiri, Kentaro| Taya, Satoshi| Saito, Yukihiro| Kuroda, Kazuhiro| Takaya, Yoichi| Toh, Norihisa| Nakayama, Rie| Katanosaka, Yuki| Yuasa, Shinsuke|
Keywords group 3 pulmonary hypertension hypoxic pulmonary vasoconstriction pulmonary vascular remodeling
Published Date 2025-01-20
Publication Title International Journal of Molecular Sciences
Volume volume26
Issue issue2
Publisher MDPI
Start Page 835
ISSN 1661-6596
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 by the authors.
File Version publisher
PubMed ID 39859549
DOI 10.3390/ijms26020835
Web of Science KeyUT 001404516000001
Related Url isVersionOf https://doi.org/10.3390/ijms26020835
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Author Tang, Xiaoyu| Zhang, Xi| Wang, Tingting| Yu, Hongtao| Wang, Aijun| Zhang, Ming|
Keywords cognitive control congruency sequence effect cross-modal conflict adaptation visual dominance
Published Date 2024-12-18
Publication Title Frontiers in Psychology
Volume volume15
Publisher Frontiers Media
Start Page 1504068
ISSN 1664-1078
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Tang, Zhang, Wang, Yu, Wang and Zhang.
File Version publisher
PubMed ID 39744030
DOI 10.3389/fpsyg.2024.1504068
Web of Science KeyUT 001390014600001
Related Url isVersionOf https://doi.org/10.3389/fpsyg.2024.1504068
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Author Umeda, Tsuyoshi| Otani, Yoshihiro| Fujii, Kentaro| Ishida, Joji| Hirano, Shuichiro| Suruga, Yasuki| Kemmotsu, Naoya| Imoto, Ryoji| Kegoya, Yasuhito| Mizuta, Ryo| Inoue, Yohei| Hokama, Madoka| Makihara, Seiichiro| Hasegawa, Kosei| Inagaki, Kenichi| Otsuka, Fumio| Yasuhara, Takao| Tanaka, Shota|
Keywords Craniopharyngioma Functional prognosis Obesity Tumor size Social participation Hypothalamic involvement
Note The version of record of this article, first published in Journal of Neuro-Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11060-024-04925-7|
Published Date 2025-01-22
Publication Title Journal of Neuro-Oncology
Volume volume172
Issue issue2
Publisher Springer Science and Business Media LLC
Start Page 471
End Page 479
ISSN 0167-594X
NCID AA10633712
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 39841323
DOI 10.1007/s11060-024-04925-7
Web of Science KeyUT 001401916600001
Related Url isVersionOf https://doi.org/10.1007/s11060-024-04925-7