start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Vendor‐Agnostic Vision Transformer‐Based Artificial Intelligence for Peroral Cholangioscopy: Diagnostic Performance in Biliary Strictures Compared With Convolutional Neural Networks and Endoscopists
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objectives: Accurate diagnosis of biliary strictures remains challenging. This study aimed to develop an artificial intelligence (AI) system for peroral cholangioscopy (POCS) using a Vision Transformer (ViT) architecture and to evaluate its performance compared to different vendor devices, conventional convolutional neural networks (CNNs), and endoscopists.<br>
Methods: We retrospectively analyzed 125 patients with indeterminate biliary strictures who underwent POCS between 2012 and 2024. AI models including the ViT architecture and two established CNN architectures were developed using images from CHF-B260 or B290 (CHF group; Olympus Medical) and SpyScope DS or DS II (Spy group; Boston Scientific) systems via a patient-level, 3-fold cross-validation. For a direct comparison against endoscopists, a balanced 440-image test set, containing an equal number of images from each vendor, was used for a blinded evaluation.<br>
Results: The 3-fold cross-validation on the entire 2062-image dataset yielded a robust accuracy of 83.9% (95% confidence interval (CI), 80.9–86.7) for the ViT model. The model's accuracy was consistent between CHF (82.7%) and Spy (86.8%, p = 0.198) groups, and its performance was comparable to the evaluated conventional CNNs. On the 440-image test set, the ViT's accuracy of 78.4% (95% CI, 72.5–83.8) was comparable to that of expert endoscopists (82.0%, p = 0.148) and non-experts (73.0%, p = 0.066), with no statistically significant differences observed.<br>
Conclusions: The novel ViT-based AI model demonstrated high vendor-agnostic diagnostic accuracy across multiple POCS systems, achieving performance comparable to conventional CNNs and endoscopists evaluated in this study.
en-copyright=
kn-copyright=

en-aut-name=SatoRyosuke
en-aut-sei=Sato
en-aut-mei=Ryosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsumotoKazuyuki
en-aut-sei=Matsumoto
en-aut-mei=Kazuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TomiyaMasahiro
en-aut-sei=Tomiya
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TanimotoTakayoshi
en-aut-sei=Tanimoto
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OhtoAkimitsu
en-aut-sei=Ohto
en-aut-mei=Akimitsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OkiKentaro
en-aut-sei=Oki
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KajitaniSatoshi
en-aut-sei=Kajitani
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KikuchiTatsuya
en-aut-sei=Kikuchi
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MatsumiAkihiro
en-aut-sei=Matsumi
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MiyamotoKazuya
en-aut-sei=Miyamoto
en-aut-mei=Kazuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=FujiiYuki
en-aut-sei=Fujii
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=UchidaDaisuke
en-aut-sei=Uchida
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=TsutsumiKoichiro
en-aut-sei=Tsutsumi
en-aut-mei=Koichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=HoriguchiShigeru
en-aut-sei=Horiguchi
en-aut-mei=Shigeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KawaharaYoshiro
en-aut-sei=Kawahara
en-aut-mei=Yoshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=OtsukaMotoyuki
en-aut-sei=Otsuka
en-aut-mei=Motoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Healthcare Solutions Division, Ryobi Systems Co., Ltd
kn-affil=

affil-num=4
en-affil=Healthcare Solutions Division, Ryobi Systems Co., Ltd
kn-affil=

affil-num=5
en-affil=Healthcare Solutions Division, Ryobi Systems Co., Ltd
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=12
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=13
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=14
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=15
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=16
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=
en-keyword=artificial intelligence
kn-keyword=artificial intelligence
en-keyword=bile duct neoplasms
kn-keyword=bile duct neoplasms
en-keyword=cholangioscopy
kn-keyword=cholangioscopy
en-keyword=computer-assisted diagnosis
kn-keyword=computer-assisted diagnosis
en-keyword=vision transformer
kn-keyword=vision transformer
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=17
article-no=
start-page=1305
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250822
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Discovery and Functional Characterization of Novel Aquaporins in Tomato (Solanum lycopersicum): Implications for Ion Transport and Salinity Tolerance
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Aquaporins (AQPs) are membrane proteins that facilitate the transport of water and solutes. Among AQPs, plasma membrane intrinsic proteins (PIPs) play a critical role in maintaining water balance between the internal and external cell environments. This study focuses on the tomato due to its economic importance and cultivation under moderate salinity conditions in Japan. A swelling assay using X. laevis oocyte confirmed that all five examined tomato SlPIP2 isoforms showed water transport activity. Among them, two-electrode voltage clamp (TEVC) experiments showed that only SlPIP2;1, SlPIP2;4, and SlPIP2;8 transport Na+ and K+, with no transport activity for Cs+, Rb+, Li+, or Cl−. CaCl2 (1.8 mM) reduced ionic currents by approximately 45% compared to 30 µM free-Ca2+. These isoforms function as very low-affinity Na+ and K+ transporters. Expression analysis showed that SlPIP2;4 and SlPIP2;8 had low, stable expression, while SlPIP2;1 was strongly upregulated in roots NaCl treatment (200 mM, 17days), suggesting distinct physiological roles for these ion-conducting AQPs (icAQPs). These data hypothesized that tomato icAQPs play a critical role in ion homeostasis, particularly under salinity stress. In conclusion, the first icAQPs have been identified in the dicotyledonous crop. These icAQPs are essential for plant resilience under salt stress.
en-copyright=
kn-copyright=

en-aut-name=PaulNewton Chandra
en-aut-sei=Paul
en-aut-mei=Newton Chandra
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ImranShahin
en-aut-sei=Imran
en-aut-mei=Shahin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MitsumotoAnri
en-aut-sei=Mitsumoto
en-aut-mei=Anri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MoriIzumi C.
en-aut-sei=Mori
en-aut-mei=Izumi C.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KatsuharaMaki
en-aut-sei=Katsuhara
en-aut-mei=Maki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=4
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=Aquaporin (AQP)
kn-keyword=Aquaporin (AQP)
en-keyword=ion transport
kn-keyword=ion transport
en-keyword=plasma membrane intrinsic proteins (PIPs)
kn-keyword=plasma membrane intrinsic proteins (PIPs)
en-keyword=tomato
kn-keyword=tomato
en-keyword=oocytes
kn-keyword=oocytes
en-keyword=water transport
kn-keyword=water transport
END

start-ver=1.4
cd-journal=joma
no-vol=343
cd-vols=
no-issue=
article-no=
start-page=103558
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202509
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Progress in silicon-based materials for emerging solar-powered green hydrogen (H2) production
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The imperative demand for sustainable and renewable energy solutions has precipitated profound scientific investigations into photocatalysts designed for the processes of water splitting and hydrogen fuel generation. The abundance, low toxicity, high conductivity, and cost-effectiveness of silicon-based compounds make them attractive candidates for hydrogen production, driving ongoing research and technological advancements. Developing an effective synthesis method that is simple, economically feasible, and environmentally friendly is crucial for the widespread implementation of silicon-based heterojunctions for sustainable hydrogen production. Balancing the performance benefits with the economic and environmental considerations is a key challenge in the development of these systems. The specific performance of each catalyst type can vary depending on the synthesis method, surface modifications, catalyst loading, and reaction conditions. The confluence of high crystallinity, reduced oxygen concentration, and calcination temperature within the silicon nanoparticle has significantly contributed to its noteworthy hydrogen evolution rate. This review provides an up-to-date evaluation of Si-based photocatalysts, summarizing recent developments, guiding future research directions, and identifying areas that require further investigation. By combining theoretical insights and experimental findings, this review offers a comprehensive understanding of Si-based photocatalysts for water splitting. Through a comprehensive analysis, it aims to elucidate existing knowledge gaps and inspire future research directions towards optimized photocatalytic performance and scalability, ultimately contributing to the realization of sustainable hydrogen generation.
en-copyright=
kn-copyright=

en-aut-name=IslamAminul
en-aut-sei=Islam
en-aut-mei=Aminul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IslamMd. Tarekul
en-aut-sei=Islam
en-aut-mei=Md. Tarekul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TeoSiow Hwa
en-aut-sei=Teo
en-aut-mei=Siow Hwa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MahmudHasan
en-aut-sei=Mahmud
en-aut-mei=Hasan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SwarazA.M.
en-aut-sei=Swaraz
en-aut-mei=A.M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=RehanAriyan Islam
en-aut-sei=Rehan
en-aut-mei=Ariyan Islam
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=RaseeAdiba Islam
en-aut-sei=Rasee
en-aut-mei=Adiba Islam
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KubraKhadiza Tul
en-aut-sei=Kubra
en-aut-mei=Khadiza Tul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HasanMd. Munjur
en-aut-sei=Hasan
en-aut-mei=Md. Munjur
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SalmanMd. Shad
en-aut-sei=Salman
en-aut-mei=Md. Shad
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=WaliullahR.M.
en-aut-sei=Waliullah
en-aut-mei=R.M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=HasanMd. Nazmul
en-aut-sei=Hasan
en-aut-mei=Md. Nazmul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SheikhMd. Chanmiya
en-aut-sei=Sheikh
en-aut-mei=Md. Chanmiya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=UchidaTetsuya
en-aut-sei=Uchida
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=AwualMrs Eti
en-aut-sei=Awual
en-aut-mei=Mrs Eti
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=HossainMohammed Sohrab
en-aut-sei=Hossain
en-aut-mei=Mohammed Sohrab
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=ZnadHussein
en-aut-sei=Znad
en-aut-mei=Hussein
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=AwualMd. Rabiul
en-aut-sei=Awual
en-aut-mei=Md. Rabiul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

affil-num=1
en-affil=Department of Petroleum and Mining Engineering, Jashore University of Science and Technology
kn-affil=

affil-num=2
en-affil=Department of Leather Engineering, Faculty of Mechanical Engineering, Khulna University of Engineering and Technology
kn-affil=

affil-num=3
en-affil=Industrial Chemistry Program, Faculty of Science and Natural Resources, Universiti Malaysia Sabah
kn-affil=

affil-num=4
en-affil=Bangladesh Energy and Power Research Council (BEPRC)
kn-affil=

affil-num=5
en-affil=Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology
kn-affil=

affil-num=6
en-affil=Department of Chemistry, School of Science, The University of Tokyo
kn-affil=

affil-num=7
en-affil=Department of Chemistry, Graduate School of Science, Osaka University
kn-affil=

affil-num=8
en-affil=Department of Chemistry, Graduate School of Science, Osaka University
kn-affil=

affil-num=9
en-affil=Department of Chemistry, Graduate School of Science, Osaka University
kn-affil=

affil-num=10
en-affil=Institute for Chemical Research, Kyoto University
kn-affil=

affil-num=11
en-affil=Institute for Chemical Research, Kyoto University
kn-affil=

affil-num=12
en-affil=Department of Chemistry, School of Science, The University of Tokyo
kn-affil=

affil-num=13
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=14
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=15
en-affil=Department of Chemistry, Graduate School of Science, Osaka University
kn-affil=

affil-num=16
en-affil=Department of Chemistry, Graduate School of Science, Osaka University
kn-affil=

affil-num=17
en-affil=Western Australian School of Mines: Minerals, Energy and Chemical Engineering, Curtin University
kn-affil=

affil-num=18
en-affil=Western Australian School of Mines: Minerals, Energy and Chemical Engineering, Curtin University
kn-affil=
en-keyword=Silicon-based materials
kn-keyword=Silicon-based materials
en-keyword=Water splitting
kn-keyword=Water splitting
en-keyword=Hydrogen
kn-keyword=Hydrogen
en-keyword=Sustainable
kn-keyword=Sustainable
en-keyword=Clean and renewable energy
kn-keyword=Clean and renewable energy
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=2
article-no=
start-page=606
end-page=617
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mechanistic Insights Into Oxidative Response of Heat Shock Factor 1 Condensates
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Heat shock factor 1 (Hsf1), a hub protein in the stress response and cell fate decisions, senses the strength, type, and duration of stress to balance cell survival and death through an unknown mechanism. Recently, changes in the physical property of Hsf1 condensates due to persistent stress have been suggested to trigger apoptosis, highlighting the importance of biological phase separation and transition in cell fate decisions. In this study, the mechanism underlying Hsf1 droplet formation and oxidative response was investigated through 3D refractive index imaging of the internal architecture, corroborated by molecular dynamics simulations and biophysical/biochemical experiments. We found that, in response to oxidative conditions, Hsf1 formed liquid condensates that suppressed its internal mobility. Furthermore, these conditions triggered the hyper-oligomerization of Hsf1, mediated by disulfide bonds and secondary structure stabilization, leading to the formation of dense core particles in the Hsf1 droplet. Collectively, these data demonstrate how the physical property of Hsf1 condensates undergoes an oxidative transition by sensing redox conditions to potentially drive cell fate decisions.
en-copyright=
kn-copyright=

en-aut-name=KawagoeSoichiro
en-aut-sei=Kawagoe
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsusakiMotonori
en-aut-sei=Matsusaki
en-aut-mei=Motonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MabuchiTakuya
en-aut-sei=Mabuchi
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OgasawaraYuto
en-aut-sei=Ogasawara
en-aut-mei=Yuto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WatanabeKazunori
en-aut-sei=Watanabe
en-aut-mei=Kazunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IshimoriKoichiro
en-aut-sei=Ishimori
en-aut-mei=Koichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SaioTomohide
en-aut-sei=Saio
en-aut-mei=Tomohide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Institute of Advanced Medical Sciences, Tokushima University
kn-affil=

affil-num=2
en-affil=Institute of Advanced Medical Sciences, Tokushima University
kn-affil=

affil-num=3
en-affil=Frontier Research Institute for Interdisciplinary Sciences, Tohoku University
kn-affil=

affil-num=4
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Chemistry, Faculty of Science, Hokkaido University
kn-affil=

affil-num=7
en-affil=Institute of Advanced Medical Sciences, Tokushima University
kn-affil=
en-keyword=heat shock factor 1
kn-keyword=heat shock factor 1
en-keyword=oxidative hyper-oligomerization
kn-keyword=oxidative hyper-oligomerization
en-keyword=biological phase transition
kn-keyword=biological phase transition
en-keyword=stress response
kn-keyword=stress response
en-keyword=biophysics
kn-keyword=biophysics
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=16
article-no=
start-page=7832
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250813
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Synergistic Antimicrobial Activity of BrSPR20-P1 Peptide and Silver Nanoparticles Against Pathogenic Bacteria
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Bacterial infection is a cause of life-threatening diseases. The emergence of antimicrobial-resistant bacteria exacerbates this situation, highlighting the need for the discovery of new antimicrobial agents. Our previous study identified a novel antimicrobial peptide, BrSPR20-P1 (P1), which showed potential activity against MRSA. Additionally, silver nanoparticles (AgNPs) exhibit broad-spectrum antibacterial activity, capable of killing multidrug-resistant bacteria. The combination of antimicrobial agents presents a novel strategy for combating these pathogens. This study aimed to evaluate the antibacterial activity of the combination of P1 and AgNPs. It revealed that the combinations showed synergy. The P1 and AgNP mixture at a concentration of 1 and 8 µg/mL (1:8) doubled the activity against S. aureus and MRSA, while that combination of 64 and 64 µg/mL (64:64) exhibited broad-spectrum activity, expanding to E. coli with a 32-fold increase. These combinations exhibited a bactericidal effect, showing the rapid killing of tested bacteria at 10× MIC, with killing rates during the first 3 h ranging from 4.04 ± 0.01 to 4.31 ± 0.03 h−1. The P1 and AgNP mixtures caused a low risk of antibacterial resistance up to 30 passages. It was demonstrated that the synergistic activity of P1 and AgNPs occurred through the disruption of cell walls and membranes, leakage of intracellular materials, and cell lysis. Additionally, the mixtures appeared to interact with bacterial genomic DNA, as indicated by a gel retardation assay. These activities of the combinations were concentration-dependent. The 1:8 µg/mL mixture caused low hemolysis and cytotoxicity and did not impede the wound healing process. In contrast, although the 64:64 µg/mL mixture showed excellent antibacterial efficacy, it was toxic to erythrocytes and mammalian cells. It implies that dose optimization is required to balance its efficacy and toxicity. Therefore, the P1 and AgNP combinations exhibit synergistic antimicrobial activity and have the potential to resolve bacterial infections.
en-copyright=
kn-copyright=

en-aut-name=ThonginThanyamai
en-aut-sei=Thongin
en-aut-mei=Thanyamai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SawatdeeSomchai
en-aut-sei=Sawatdee
en-aut-mei=Somchai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SongnakaNuttapon
en-aut-sei=Songnaka
en-aut-mei=Nuttapon
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UchiyamaJumpei
en-aut-sei=Uchiyama
en-aut-mei=Jumpei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WiwasukuTheanchai
en-aut-sei=Wiwasuku
en-aut-mei=Theanchai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SrichanaTeerapol
en-aut-sei=Srichana
en-aut-mei=Teerapol
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakphengTitpawan
en-aut-sei=Nakpheng
en-aut-mei=Titpawan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=AtipairinApichart
en-aut-sei=Atipairin
en-aut-mei=Apichart
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil= School of Pharmacy, Walailak University
kn-affil=

affil-num=2
en-affil= School of Pharmacy, Walailak University
kn-affil=

affil-num=3
en-affil= School of Pharmacy, Walailak University
kn-affil=

affil-num=4
en-affil=Department of Bacteriology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=School of Science, Walailak University
kn-affil=

affil-num=6
en-affil=Drug Delivery System Excellence Center and Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University
kn-affil=

affil-num=7
en-affil=Drug Delivery System Excellence Center and Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University
kn-affil=

affil-num=8
en-affil= School of Pharmacy, Walailak University
kn-affil=
en-keyword=antimicrobial peptide
kn-keyword=antimicrobial peptide
en-keyword=Brevibacillus sp. SPR20
kn-keyword=Brevibacillus sp. SPR20
en-keyword=silver nanoparticle
kn-keyword=silver nanoparticle
en-keyword=synergistic effect
kn-keyword=synergistic effect
END

start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=8
article-no=
start-page=1621
end-page=1630
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250606
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Percutaneous cryoablation versus robot-assisted partial nephrectomy for small renal cell carcinoma: a retrospective cost analysis at Japanese single-institution
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: No direct cost comparison has been conducted between percutaneous cryoablation (PCA) and robot-assisted partial nephrectomy (RAPN) for clinical T1a renal cell carcinoma (RCC) in Japan. This study aimed to compare their costs.<br>
Methods: We retrospectively analyzed data from 212 PCAs (including 155 with transcatheter arterial embolization) and 119 RAPN cases performed between December 2017 and May 2022.<br>
Results: PCA patients were older with higher American Society of Anesthesiologists scores, Charlson Comorbidity Index, and history of previous RCC treatment, cardiovascular disease, and antithrombotic drug use than RAPN patients. PCA was associated with a significantly shorter procedure time and hospitalization duration with fewer major complications than those associated with RAPN. While PCA incurred a slightly lower total cost (1,123,000 vs. 1,155,000 yen), it had a significantly higher procedural cost (739,000 vs. 693,000 yen) and markedly worse total (− 93,000 vs. 249,000 yen) and procedural income-expenditure balance (− 189,000 vs. 231,000 yen) than those of RAPN. After statistical adjustment, PCA demonstrated significantly higher total (difference: 114,000 yen) and procedural costs (difference: 72,000 yen), alongside significantly worse total (difference: − 358,000 yen) and procedural income-expenditure balances (difference: − 439,000 yen). The incremental cost-effectiveness ratio was more favorable for PCA than for RAPN.<br>
Conclusion: For high- risk patients, PCA demonstrated a safer option with shorter hospitalization duration than those of RAPN. Although PCA was more cost-effective, its higher procedural cost and unfavorable income-expenditure balance require careful evaluation, especially for large tumors that require three or more needles.
en-copyright=
kn-copyright=

en-aut-name=UkaMayu
en-aut-sei=Uka
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IguchiToshihiro
en-aut-sei=Iguchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=BekkuKensuke
en-aut-sei=Bekku
en-aut-mei=Kensuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamanoiTomoaki
en-aut-sei=Yamanoi
en-aut-mei=Tomoaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MitsuhashiToshiharu
en-aut-sei=Mitsuhashi
en-aut-mei=Toshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=GobaraHideo
en-aut-sei=Gobara
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=UmakoshiNoriyuki
en-aut-sei=Umakoshi
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KawabataTakahiro
en-aut-sei=Kawabata
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TomitaKoji
en-aut-sei=Tomita
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MatsuiYusuke
en-aut-sei=Matsui
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=ArakiMotoo
en-aut-sei=Araki
en-aut-mei=Motoo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=HirakiTakao
en-aut-sei=Hiraki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Division of Medical Informatics, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Renal cancer
kn-keyword=Renal cancer
en-keyword=Cryoablation
kn-keyword=Cryoablation
en-keyword=Robot-assisted partial nephrectomy
kn-keyword=Robot-assisted partial nephrectomy
en-keyword=Cost
kn-keyword=Cost
en-keyword=Cost effectiveness
kn-keyword=Cost effectiveness
END

start-ver=1.4
cd-journal=joma
no-vol=57
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=20
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250724
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Re-Thinking the Locus of Innovation
kn-title=イノベーションの発生源研究の再検討
en-subtitle=
kn-subtitle=
en-abstract=　This study aims to theoretically examine prior research on the locus of innovation, with a particular focus on clarifying "when," "where," and "by whom" innovation is generated. The analysis reveals that in the context of B to B (Industrial Goods) , the shift of innovation sources toward enterprise users has been explained from the perspective of economic rationality, incorporating multiple factors such as transaction cost, expected innovation rents, sticky information, internal capabilities (Absorptive Capacity) , and external industrial structures (Product Architecture, Ecosystem) . In contrast, in the B to C context (Consumer Goods) , end users pursue innovation for a wide variety of reasons, including manufacturers' lack of responsiveness to niche markets, the enjoyment of creative activity, connection with user communities, and personal growth. Among these, the enjoyment derived from creative activity has deemed to be identified as one of the most fundamental motivational factors. However, the methodological articulation of such psychological factors is not enough. Leaving the psychological drivers behind innovation as a black box is not merely a matter of academic curiosity but presents a significant challenge for management studies as a social science. This is because management is always purposive attempts for directing and controlling the process of value creation and sometimes psychological exaltation, which may be recently called 'flow' experience, may conflict such attempts. In future research on the locus of innovation, it is essential to focus on these psychological aspects of individual innovator and to develop new research approaches. First, it has a room for further elucidation of the mechanisms by which positive emotions contribute to innovation, but this challenge is hardly easy to overcome. Since creativity is essentially a construct of the individual level and innovation is not, the argument of balancing the entrepreneurial motivational drivers and the managerial direction and control of creative destruction needs to be mediated by meso-level constructs. In our prospect, such concepts as underdeveloped ecosystem on the supply side and immature connoisseur on the side of consumers may be promising. Another concern is the generally limited sample size of creative minds. The existent research tactics that have been found in our neighboring disciplines sharing the same problem as ours, either qualitative or quantitative, may provide us with methodical benchmarks.
kn-abstract=　本論文は，イノベーションの発生源に関する先行研究を振り返り，「いつ」「どこで」「誰によって」イノベーションが生み出されるのかを理論的に考察することを目的とする。考察の結果，「B to B」の文脈においては，イノベーションの発生源が企業ユーザーへ移行するメカニズムとして，取引コスト理論，期待利益仮説，情報粘着性の仮説，企業内部の独自能力（吸収能力），および外部の産業構造（製品アーキテクチャ・エコシステム）といった複数の要素からなる経済的合理性の観点から分析されていることが明らかになった。一方，「B to C」の文脈では，エンドユーザーがイノベーションに向かう動機として，「ニッチ市場に対するメーカーの消極的な対応」「創造的活動の楽しさ」「ユーザーコミュニティとの繋がり」「知識・スキルの向上」など多種多様な要素が存在し，中でも創造的活動の楽しさが根源的な動機づけの1つであると確認された。一方で，イノベーターを突き動かす心理的要因をブラックボックス化したまま放置することは，単なる知的好奇心の問題に留まらず，社会科学としての経営学にとっても重要な問題であると考えられる。今後のイノベーションの発生源研究においては，起業家をはじめとするイノベーター個人の心理的側面にいかに目を向け，創造的活動におけるポジティブな感情が働くメカニズムをイノベーションの発生メカニズムにいかに位置づけるか，その研究アプローチの提示が求められる。
en-copyright=
kn-copyright=

en-aut-name=HuangQi
en-aut-sei=Huang
en-aut-mei=Qi
kn-aut-name=黄琪
kn-aut-sei=黄
kn-aut-mei=琪
aut-affil-num=1
ORCID=

en-aut-name=FujiiDaiji
en-aut-sei=Fujii
en-aut-mei=Daiji
kn-aut-name=藤井大児
kn-aut-sei=藤井
kn-aut-mei=大児
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院ヘルスシステム統合科学研究科

affil-num=2
en-affil=
kn-affil=岡山大学学術研究院ヘルスシステム統合科学学域
en-keyword=イノベーションの発生源 (Locus of Innovation)
kn-keyword=イノベーションの発生源 (Locus of Innovation)
en-keyword=ユーザーイノベーション (User Innovation)
kn-keyword=ユーザーイノベーション (User Innovation)
en-keyword=経済的合理性 (Economic Rationality)
kn-keyword=経済的合理性 (Economic Rationality)
en-keyword=内発的動機づけ (Intrinsic Motivation)
kn-keyword=内発的動機づけ (Intrinsic Motivation)
en-keyword=フロー体験 (Flow Experience)
kn-keyword=フロー体験 (Flow Experience)
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=ncaf080
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250718
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Optimizing radiation dose and image quality in neonatal mobile radiography
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Children are more susceptible to radiation exposure than adults. Therefore, determining an appropriate radiation dose requires balancing and minimizing radiation exposure while maintaining image quality (IQ) for accurate diagnosis. We evaluated the optimal radiation dose parameters for neonatal chest and abdominal mobile radiography by assessing entrance surface dose and IQ indices. A range of exposure parameters was tested on neonatal and acrylic phantoms, and the optimal settings were determined through visual and physical evaluations. Overall, 65 kVp and 1.2 mAs provided the best balance between minimizing radiation exposure and maintaining high IQ for neonates. This study offers essential insights into optimizing radiographic conditions for neonatal care, contributing to safe and effective radiological practices. These optimized parameters can help guide future clinical applications by ensuring reduced radiation risk and enhanced diagnostic accuracy.
en-copyright=
kn-copyright=

en-aut-name=MaedaTakahiko
en-aut-sei=Maeda
en-aut-mei=Takahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HaraMakoto
en-aut-sei=Hara
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamasakiHiroyuki
en-aut-sei=Yamasaki
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakaharaMakoto
en-aut-sei=Nakahara
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TanabeYoshinori
en-aut-sei=Tanabe
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Health Sciences, Department of Radiological Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Radiology, Hyogo Prefectural Kobe Children’s Hospital
kn-affil=

affil-num=3
en-affil=Department of Radiology, Hyogo Prefectural Kobe Children’s Hospital
kn-affil=

affil-num=4
en-affil=Department of Radiology, Hyogo Prefectural Tamba Medical Center
kn-affil=

affil-num=5
en-affil=Faculty of Medicine, Graduate School of Health Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=2
article-no=
start-page=e70108
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250421
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A case report of ineffective electroconvulsive therapy for chronic pain
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Somatic symptom disorder (SSD), which includes chronic pain, is a common mental disorder characterized by significant functional impairment and other psychiatric comorbidities. Electroconvulsive therapy (ECT) has been proposed as a potential treatment for refractory chronic pain. However, evidence supporting its efficacy is limited and/or low quality. We present a case of SSD with chronic pain in which ECT was ineffective.<br>
Case Presentation: The patient was a 63-year-old man with chronic pain in the lower back, buttocks, thighs, and soles of the feet. The duration of his chronic pain was 3.8 years. He was diagnosed with Bertolotti's syndrome and SSD. He did not meet the criteria for major depressive disorder. He kept physically active by walking and doing exercises to distract himself from his pain. He strongly perceived pain as a physical issue and preferred ECT over psychotherapy. Despite undergoing 10 ECT sessions with adequate seizures, his pain persisted. After four sessions, he experienced despair over the lack of improvement in pain, which temporarily intensified his suicidal ideation. After undergoing ECT, he continued to maintain his activities, including walking and exercise, while his catastrophic thinking about pain persisted.<br>
Conclusion: The ineffectiveness of ECT in this case highlights the need for balanced counseling, particularly for patients who consider ECT a last-resort treatment. Psychological monitoring and depression screening are essential, especially given the risk of heightened despair or suicidal ideation when ECT is ineffective. Therefore, collaborative decision-making based on accurate information is vital.
en-copyright=
kn-copyright=

en-aut-name=FukaoTakashi
en-aut-sei=Fukao
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FujiwaraMasaki
en-aut-sei=Fujiwara
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamadaYuto
en-aut-sei=Yamada
en-aut-mei=Yuto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AsadaKazushi
en-aut-sei=Asada
en-aut-mei=Kazushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AsadaTakahiro
en-aut-sei=Asada
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=RiHirotoshi
en-aut-sei=Ri
en-aut-mei=Hirotoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SakamotoShinji
en-aut-sei=Sakamoto
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakakiManabu
en-aut-sei=Takaki
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Neuropsychiatry, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Neuropsychiatry, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Neuropsychiatry, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Neuropsychiatry, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Neuropsychiatry, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Neuropsychiatry, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Neuropsychiatry, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Neuropsychiatry, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=chronic pain
kn-keyword=chronic pain
en-keyword=electroconvulsive therapy
kn-keyword=electroconvulsive therapy
en-keyword=pain disorder
kn-keyword=pain disorder
en-keyword=somatic symptom disorder
kn-keyword=somatic symptom disorder
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=1
article-no=
start-page=47
end-page=50
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202502
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Immediate Effects of a Single Home-based Rehabilitation Treatment on Balance Performance and Toe-Grip Strength in Elderly Subjects Continuing the Same Rehabilitation Program
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We assessed the immediate effects of a home-based rehabilitation (HBR) program on the balance performance and toe-grip strength of 29 older adults (mean±SD age of 75.1±9.9; 16 males, 13 females) who were participating in HBR services provided by Japan’s nursing care insurance system. Their toe-grip strength and balance performance were measured before and after the HBR program. The subjects’ toe-grip strength was significantly improved after the treatment. The subjects who had had a stroke showed a significant improvement after HBR. Contrarily, no significant difference was observed in the subjects’ functional reach results or their one-leg standing time. These results indicate that the exercise regimen provided in the HBR program led to increased excitability of motor units and immediately enhanced the subjects’ toe-grip strength.
en-copyright=
kn-copyright=

en-aut-name=KojimaKazunori
en-aut-sei=Kojima
en-aut-mei=Kazunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UjikawaTakuya
en-aut-sei=Ujikawa
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Physical Therapy, Faculty of Health Sciences, Okayama Healthcare Professional University
kn-affil=

affil-num=2
en-affil=Department of Physical Therapy, Faculty of Rehabilitation, Kawasaki University of Medical Welfare
kn-affil=

affil-num=3
en-affil=Department of Occupational Therapy, Faculty of Health Sciences, Okayama Healthcare Professional University
kn-affil=
en-keyword=home-based rehabilitation
kn-keyword=home-based rehabilitation
en-keyword=toe-grip strength
kn-keyword=toe-grip strength
en-keyword=balance performance
kn-keyword=balance performance
END

start-ver=1.4
cd-journal=joma
no-vol=741
cd-vols=
no-issue=
article-no=
start-page=151006
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=S-adenosylmethionine and S-adenosyl-L-homocysteine metabolism is involved in the sperm motility and in vitro fertility rate in mouse
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Increased fragmentation of sperm DNA has been implicated in male infertility. Folate deficiency results in impaired methionine synthesis, depletion of S-adenosylmethionine (SAM) levels, an increase in S-adenosyl-l-homocysteine (SAH) levels, and increased DNA fragmentation. Disruption of the dynamic balance between SAM and SAH may also contribute, although the details of this process are not yet fully understood. We investigated the localization of SAM, SAH, and S-adenosylhomocysteine hydrolase (SAHH), and whether SAM/SAH metabolism contributes to sperm motility and fertilization rate. SAM, SAH, and SAHH levels were assessed in the acrosome, midpiece, and tail of spermatozoa. Chemical inhibition of SAM/SAH metabolism and extracellular SAH significantly decreased the straight-line velocity (VSL), curvilinear velocity (VCL), and amplitude lateral head displacement (ALH) of sperm cells, which were thus unable to swim forward and perform oscillatory movements in place. This significantly reduced the fertilization rate. Therefore, the disruption of the SAM/SAH balance may contribute to male infertility.
en-copyright=
kn-copyright=

en-aut-name=KawaiTomoko
en-aut-sei=Kawai
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FujimuraAtsushi
en-aut-sei=Fujimura
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Cellular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cellular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=SAM/SAH metabolism
kn-keyword=SAM/SAH metabolism
en-keyword=Sperm motility
kn-keyword=Sperm motility
en-keyword=Fertilization rate
kn-keyword=Fertilization rate
END

start-ver=1.4
cd-journal=joma
no-vol=17
cd-vols=
no-issue=1
article-no=
start-page=29
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Three-Class Annotation Method Improves the AI Detection of Early-Stage Osteosarcoma on Plain Radiographs: A Novel Approach for Rare Cancer Diagnosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background/Objectives: Developing high-performance artificial intelligence (AI) models for rare diseases is challenging owing to limited data availability. This study aimed to evaluate whether a novel three-class annotation method for preparing training data could enhance AI model performance in detecting osteosarcoma on plain radiographs compared to conventional single-class annotation. Methods: We developed two annotation methods for the same dataset of 468 osteosarcoma X-rays and 378 normal radiographs: a conventional single-class annotation (1C model) and a novel three-class annotation method (3C model) that separately labeled intramedullary, cortical, and extramedullary tumor components. Both models used identical U-Net-based architectures, differing only in their annotation approaches. Performance was evaluated using an independent validation dataset. Results: Although both models achieved high diagnostic accuracy (AUC: 0.99 vs. 0.98), the 3C model demonstrated superior operational characteristics. At a standardized cutoff value of 0.2, the 3C model maintained balanced performance (sensitivity: 93.28%, specificity: 92.21%), whereas the 1C model showed compromised specificity (83.58%) despite high sensitivity (98.88%). Notably, at the 25th percentile threshold, both models showed identical false-negative rates despite significantly different cutoff values (3C: 0.661 vs. 1C: 0.985), indicating the ability of the 3C model to maintain diagnostic accuracy at substantially lower thresholds. Conclusions: This study demonstrated that anatomically informed three-class annotation can enhance AI model performance for rare disease detection without requiring additional training data. The improved stability at lower thresholds suggests that thoughtful annotation strategies can optimize the AI model training, particularly in contexts where training data are limited.
en-copyright=
kn-copyright=

en-aut-name=HaseiJoe
en-aut-sei=Hasei
en-aut-mei=Joe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakaharaRyuichi
en-aut-sei=Nakahara
en-aut-mei=Ryuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OtsukaYujiro
en-aut-sei=Otsuka
en-aut-mei=Yujiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakamuraYusuke
en-aut-sei=Nakamura
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IkutaKunihiro
en-aut-sei=Ikuta
en-aut-mei=Kunihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OsakiShuhei
en-aut-sei=Osaki
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HironariTamiya
en-aut-sei=Hironari
en-aut-mei=Tamiya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MiwaShinji
en-aut-sei=Miwa
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OhshikaShusa
en-aut-sei=Ohshika
en-aut-mei=Shusa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=NishimuraShunji
en-aut-sei=Nishimura
en-aut-mei=Shunji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KaharaNaoaki
en-aut-sei=Kahara
en-aut-mei=Naoaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=YoshidaAki
en-aut-sei=Yoshida
en-aut-mei=Aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=FujiwaraTomohiro
en-aut-sei=Fujiwara
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=NakataEiji
en-aut-sei=Nakata
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KunisadaToshiyuki
en-aut-sei=Kunisada
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

affil-num=1
en-affil=Department of Medical Information and Assistive Technology Development, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Science of Functional Recovery and Reconstruction, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Radiology, Juntendo University School of Medicine
kn-affil=

affil-num=4
en-affil=Plusman LCC
kn-affil=

affil-num=5
en-affil=Department of Orthopedic Surgery, Graduate School of Medicine, Nagoya University
kn-affil=

affil-num=6
en-affil=Department of Musculoskeletal Oncology and Rehabilitation, National Cancer Center Hospital
kn-affil=

affil-num=7
en-affil=Department of Musculoskeletal Oncology Service, Osaka International Cancer Institute
kn-affil=

affil-num=8
en-affil=Department of Orthopedic Surgery, Kanazawa University Graduate School of Medical Sciences
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine
kn-affil=

affil-num=10
en-affil=Department of Orthopaedic Surgery, Kindai University Hospital
kn-affil=

affil-num=11
en-affil=Department of Orthopedic Surgery, Mizushima Central Hospital
kn-affil=

affil-num=12
en-affil=Science of Functional Recovery and Reconstruction, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=13
en-affil=Science of Functional Recovery and Reconstruction, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=14
en-affil=Science of Functional Recovery and Reconstruction, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=15
en-affil=Science of Functional Recovery and Reconstruction, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=16
en-affil=Science of Functional Recovery and Reconstruction, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=osteosarcoma
kn-keyword=osteosarcoma
en-keyword=medical image annotation
kn-keyword=medical image annotation
en-keyword=anatomical annotation method
kn-keyword=anatomical annotation method
en-keyword=rare cancer
kn-keyword=rare cancer
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=50
article-no=
start-page=e40849
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241213
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Relevance of oxidative stress for small intestinal injuries induced by nonsteroidal anti-inflammatory drugs: A multicenter prospective study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Several reports revealed that oxidative stress was involved in the mouse model of nonsteroidal anti-inflammatory drug (NSAIDs)-induced small intestinal mucosal injuries. Thus, we aimed to investigate in the prospective clinical study, that the relevance of oxidative stress balance in small intestinal mucosal injury in NSAIDs users. We prospectively included 60 patients who had been taking NSAIDs continuously for more than 3 months and exhibited obscure gastrointestinal bleeding (number UMIN 000011775). Small intestinal mucosal injuries were assessed by capsule endoscopy (CE), and reactive oxygen metabolites (d-ROMs) levels and oxidant capacity (OXY) adsorbent test were performed to investigate the relevance of oxidative stress balance. More than half of the patients (N = 32, 53%) had small intestinal mucosal injuries by CE, and 14 patients (24%) had ulcers. The incidence of ulcers was relatively higher in nonaspirin users. Serum OXY levels were significantly lower in the mucosal injury group (P = .02), and d-ROM levels were significantly higher in the ulcer group (P < .01). In aspirin users, d-ROM and OXY levels did not differ significantly with respect to mucosal injuries or ulcers. However, in nonaspirin users, OXY level was significantly lower in the mucosal injury group (P = .04), and d-ROM levels were significantly higher in the ulcer group (P = .02). Nonaspirin NSAIDs-induced intestinal mucosal injury is associated with antioxidant systems, resulting in increased oxidative stress.
en-copyright=
kn-copyright=

en-aut-name=BabaYuki
en-aut-sei=Baba
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KawanoSeiji
en-aut-sei=Kawano
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakakiAkinobu
en-aut-sei=Takaki
en-aut-mei=Akinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KonoYoshiyasu
en-aut-sei=Kono
en-aut-mei=Yoshiyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HoriiJoichiro
en-aut-sei=Horii
en-aut-mei=Joichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TakahashiSakuma
en-aut-sei=Takahashi
en-aut-mei=Sakuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KawaiDaisuke
en-aut-sei=Kawai
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KobayashiSayo
en-aut-sei=Kobayashi
en-aut-mei=Sayo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Internal Medicine, Japanese Red Cross Himeji Hospital
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology, National Hospital Organization Fukuyama Medical Center
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=7
en-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital
kn-affil=

affil-num=8
en-affil=Department of Internal Medicine, Fukuyama City Hospital
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=capsule endoscopy
kn-keyword=capsule endoscopy
en-keyword=NSAIDs
kn-keyword=NSAIDs
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=small intestinal mucosal injury
kn-keyword=small intestinal mucosal injury
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=12
article-no=
start-page=789
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241209
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Yoga Pose Difficulty Level Estimation Method Using OpenPose for Self-Practice System to Yoga Beginners
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Yoga is an exercise preferable for various users at different ages to enhance physical and mental health. To help beginner yoga self-practitioners avoid getting injured by selecting difficult yoga poses, the information of the difficulty level of yoga poses is very important to provide an objective metric to assist yoga self-practitioners in selecting appropriate exercises on the basis of their skill level by using the yoga self-practice system. To enhance the developed yoga self-practice system, the yoga difficulty level estimation function will enable users to clearly understand whether the selected yoga poses are suitable for them. In this paper, the newest difficulty level estimation method of yoga poses is proposed by using and analyzing OpenPose two-dimensional (2D) human body keypoints. The proposed method effectively uses the selected six keypoints areas of the upper and lower body, body support types, center of gravity calculations, and body tilt angles and slopes to produce estimations. Firstly, the method calculates the weighted centers of the upper and lower human body for each pose by using keypoints. Secondly, it refers the slope of the centroid line between the two centers and infers the body's balance state. Lastly, the system estimates the difficulty level by additionally considering the keypoints of the body to contact the ground. For evaluations of the proposal, more than one hundred yoga poses are collected from the Internet and applied to classify them into five difficulty levels. Through comparisons with subjective levels from one instructor and 10 users, the validity of the estimation results is confirmed, a comparison is performed with existing designs, and it is implemented in embedded systems.
en-copyright=
kn-copyright=

en-aut-name=ShihCheng-Liang
en-aut-sei=Shih
en-aut-mei=Cheng-Liang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=LiuJun-You
en-aut-sei=Liu
en-aut-mei=Jun-You
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AnggrainiIrin Tri
en-aut-sei=Anggraini
en-aut-mei=Irin Tri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=XiaoYanqi
en-aut-sei=Xiao
en-aut-mei=Yanqi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FunabikiNobuo
en-aut-sei=Funabiki
en-aut-mei=Nobuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FanChih-Peng
en-aut-sei=Fan
en-aut-mei=Chih-Peng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Electrical Engineering, National Chung Hsing University
kn-affil=

affil-num=2
en-affil=Department of Electrical Engineering, National Chung Hsing University
kn-affil=

affil-num=3
en-affil=Department of Electrical and Communication Engineering, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Electrical and Communication Engineering, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Electrical and Communication Engineering, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Electrical Engineering, National Chung Hsing University
kn-affil=
en-keyword=yoga
kn-keyword=yoga
en-keyword=self-practice
kn-keyword=self-practice
en-keyword=OpenPose
kn-keyword=OpenPose
en-keyword=pose difficulty level
kn-keyword=pose difficulty level
en-keyword=body keypoint
kn-keyword=body keypoint
END

start-ver=1.4
cd-journal=joma
no-vol=159
cd-vols=
no-issue=19
article-no=
start-page=194504
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20231121
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Efficiency and energy balance for substitution of CH4 in clathrate hydrates with CO2 under multiple-phase coexisting conditions
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Many experimental and theoretical studies on CH4–CO2 hydrates have been performed aiming at the extraction of CH4 as a relatively clean energy resource and concurrent sequestration of CO2. However, vague or insufficient characterization of the environmental conditions prevents us from a comprehensive understanding of even equilibrium properties of CH4–CO2 hydrates for this substitution. We propose possible reaction schemes for the substitution, paying special attention to the coexisting phases, the aqueous and/or the fluid, where CO2 is supplied from and CH4 is transferred to. We address the two schemes for the substitution operating in three-phase and two-phase coexistence. Advantages and efficiencies of extracting CH4 in the individual scheme are estimated from the chemical potentials of all the components in all the phases involved in the substitution on the basis of a statistical mechanical theory developed recently. It is found that although substitution is feasible in the three-phase coexistence, its working window in temperature–pressure space is much narrower compared to the two-phase coexistence condition. Despite that the substitution normally generates only a small amount of heat, a large endothermic substitution is suggested in the medium pressure range, caused by the vaporization of liquid CO2 due to mixing with a small amount of the released CH4. This study provides the first theoretical framework toward the practical use of hydrates replacing CH4 with CO2 and serves as a basis for quantitative planning.
en-copyright=
kn-copyright=

en-aut-name=TanakaHideki
en-aut-sei=Tanaka
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsumotoMasakazu
en-aut-sei=Matsumoto
en-aut-mei=Masakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YagasakiTakuma
en-aut-sei=Yagasaki
en-aut-mei=Takuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=2
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=3
en-affil=Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=45
cd-vols=
no-issue=1
article-no=
start-page=11
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mutation and apoptosis are well-coordinated for protecting against DNA damage-inducing toxicity in Drosophila
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Apoptotic cell death is an important survival system for multicellular organisms because it removes damaged cells. Mutation is also a survival method for dealing with damaged cells in multicellular and also unicellular organisms, when DNA lesions are not removed. However, to the best of our knowledge, no reports have comprehensively explored the direct relationship between apoptosis and somatic cell mutations induced by various mutagenic factors.<br>
Results Mutation was examined by the wing-spot test, which is used to detect somatic cell mutations, including chromosomal recombination. Apoptosis was observed in the wing discs by acridine orange staining in situ. After treatment with chemical mutagens, ultraviolet light (UV), and X-ray, both the apoptotic frequency and mutagenic activity increased in a dose-dependent manner at non-toxic doses. When we used DNA repair-deficient Drosophila strains, the correlation coefficient of the relationship between apoptosis and mutagenicity, differed from that of the wild-type. To explore how apoptosis affects the behavior of mutated cells, we determined the spot size, i.e., the number of mutated cells in a spot. In parallel with an increase in apoptosis, the spot size increased with MNU or X-ray treatment dose-dependently; however, this increase was not seen with UV irradiation. In addition, BrdU incorporation, an indicator of cell proliferation, in the wing discs was suppressed at 6 h, with peak at 12 h post-treatment with X-ray, and that it started to increase again at 24 h; however, this was not seen with UV irradiation.<br>
Conclusion Damage-induced apoptosis and mutation might be coordinated with each other, and the frequency of apoptosis and mutagenicity are balanced depending on the type of DNA damage. From the data of the spot size and BrdU incorporation, it is possible that mutated cells replace apoptotic cells due to their high frequency of cell division, resulting in enlargement of the spot size after MNU or X-ray treatment. We consider that the induction of mutation, apoptosis, and/or cell growth varies in multi-cellular organisms depending on the type of the mutagens, and that their balance and coordination have an important function to counter DNA damage for the survival of the organism.
en-copyright=
kn-copyright=

en-aut-name=Toyoshima-SasataniMegumi
en-aut-sei=Toyoshima-Sasatani
en-aut-mei=Megumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ImuraFumika
en-aut-sei=Imura
en-aut-mei=Fumika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HamatakeYuko
en-aut-sei=Hamatake
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FukunagaAkihiro
en-aut-sei=Fukunaga
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NegishiTomoe
en-aut-sei=Negishi
en-aut-mei=Tomoe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=School of Nursing, Osaka City University
kn-affil=

affil-num=5
en-affil=Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Drosophila
kn-keyword=Drosophila
en-keyword=Apoptosis
kn-keyword=Apoptosis
en-keyword=Mutation
kn-keyword=Mutation
en-keyword=Larval wing disc
kn-keyword=Larval wing disc
en-keyword=X-ray
kn-keyword=X-ray
en-keyword=Ultraviolet
kn-keyword=Ultraviolet
en-keyword=Alkylating agents
kn-keyword=Alkylating agents
en-keyword=Tobacco smoke
kn-keyword=Tobacco smoke
en-keyword=Acridine orange
kn-keyword=Acridine orange
en-keyword=BrdU
kn-keyword=BrdU
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241207
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Optimization of workflow processes for sustainable paternal involvement: case study of an academic “daddy surgeon” in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Work–life balance is often discussed in Japan. Yet surgeons find it challenging to take paternity leave because of their demanding surgical duties and a strong sense of responsibility. One Japanese male surgeon had his first paternity experience as a research fellow in the US. When he returned to Japan, he resumed his surgical training and started a research project to become an academic surgeon. When he and his wife were expecting their second child, they discussed his paternity participation before the delivery and decided on a sustainable paternity participation plan. By coordinating his responsibilities with his co-workers, he limited his attendance at work to daytime hours only for 1 month to manage paternity duties. This adjustment did not affect the number of main and assistant operations conducted that month and effective optimization of workflow processes decreased the extra workload for other team members. His experience suggests that the optimization of workflow processes can enhance personal life, including paternity participation. (150/150).
en-copyright=
kn-copyright=

en-aut-name=KanayaNobuhiko
en-aut-sei=Kanaya
en-aut-mei=Nobuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KurodaShinji
en-aut-sei=Kuroda
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KondoYoshitaka
en-aut-sei=Kondo
en-aut-mei=Yoshitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakeharaYuko
en-aut-sei=Takehara
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KakiuchiYoshihiko
en-aut-sei=Kakiuchi
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MinagiHitoshi
en-aut-sei=Minagi
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SakamotoMasaki
en-aut-sei=Sakamoto
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KagawaShunsuke
en-aut-sei=Kagawa
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KataokaHitomi
en-aut-sei=Kataoka
en-aut-mei=Hitomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Gastroenterological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Gastroenterological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Surgery, Okayama Saiseikai General Hospital
kn-affil=

affil-num=5
en-affil=Department of Gastroenterological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Gastroenterological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Gastroenterological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Gastroenterological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=9
en-affil=Integrated Clinical Education Center, Kyoto University Hospital
kn-affil=

affil-num=10
en-affil=Department of Gastroenterological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=
en-keyword=Optimization of workflow processes
kn-keyword=Optimization of workflow processes
en-keyword=Sustainable paternity participation
kn-keyword=Sustainable paternity participation
en-keyword=“Daddy surgeon”
kn-keyword=“Daddy surgeon”
END

start-ver=1.4
cd-journal=joma
no-vol=306
cd-vols=
no-issue=
article-no=
start-page=109175
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202412
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Regional-scale evaluation of tertiary irrigation system in Muda Irrigation Scheme from space
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A tertiary irrigation system is essential for efficient water management in large-scale irrigation scheme and requires regular evaluation to understand their effectiveness. The current water balance method for tertiary irrigation system evaluation requires extensive data, making continuous monitoring over vast areas unfeasible. A better approach using geospatial data from the Google Earth Engine (GEE) is introduces to evaluate the efficiency of tertiary irrigation systems on a regional scale, aiding water management strategies. This study aims to (1) define the rice cultivation boundary for accurate data collection and (2) quantitatively evaluate irrigation system performance using specific indicators. Remote sensing evapotranspiration (RS-ET) and yield derived from Normalized Difference Vegetation Index (NDVI) were collected within rice cultivation boundary across 60 irrigation blocks, including 14 blocks equipped with tertiary irrigation system in Region II of the Muda Irrigation Scheme. Three irrigation system performance indicators (equity, adequacy, and water productivity) were used as a key metric in over four rice-growing seasons to evaluate tertiary irrigation system. Results reveal that tertiary irrigation system performance varies with the current three-phase water management strategy. Equity performance was highest during the off-season, particularly in phase 1 (2–8 %). Adequacy was moderate across all phases and seasons (median: 0.6–0.67), while water productivity showed consistent strength in phases 1 and 3, with fluctuations in phase 2, across seasons. This study underscores the cost-effectiveness and efficiency of using geospatial data from space for continuous regional-scale monitoring, highlighting areas for improvement in the current water management strategy.
en-copyright=
kn-copyright=

en-aut-name=ZahirAliya Mhd
en-aut-sei=Zahir
en-aut-mei=Aliya Mhd
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SomuraHiroaki
en-aut-sei=Somura
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MoroizumiToshitsugu
en-aut-sei=Moroizumi
en-aut-mei=Toshitsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Water management
kn-keyword=Water management
en-keyword=Remote sensing
kn-keyword=Remote sensing
en-keyword=Irrigation performance
kn-keyword=Irrigation performance
en-keyword=Irrigation system
kn-keyword=Irrigation system
en-keyword=Earth observation data
kn-keyword=Earth observation data
en-keyword=Muda Irrigation Scheme
kn-keyword=Muda Irrigation Scheme
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=3
article-no=
start-page=77
end-page=83
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=2021
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of drought features in the Dakbla watershed, Central Highlands of Vietnam
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The drought impacts in the Dakbla watershed were assessed based on a combination of hydrological modeling and drought indices. Three drought indices, the Standardized Precipitation Index (SPI), Standardized Soil Moisture Index (SSI), and Streamflow Drought Index (SDI) were utilized to evaluate the drought features of meteo-hydrology and agriculture. The results indicated that these indices are well adapted to the local conditions, especially the 12-month time scale. Evaluations of drought features on the watershed scale could provide more specific information regarding drought risk than regional-scale/district-level assessments, because a watershed is a hydrologically fundamental unit to consider water resources management. Additionally, evaluations of drought impacts using the SSI showed longer and higher trends than those using the SPI and SDI in terms of drought duration and frequency. Considering the spatial distribution of drought frequency, the areas predominated by agricultural land in the target watershed had higher drought risk. Thus, assessment of agricultural droughts along with meteo-hydrological droughts is extremely important to support realistic local drought management strategies by considering water availability, water balance, and soil characteristics, especially in specific agricultural areas.
en-copyright=
kn-copyright=

en-aut-name=Ngoc Quynh TramVo
en-aut-sei=Ngoc Quynh Tram
en-aut-mei=Vo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SomuraHiroaki
en-aut-sei=Somura
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MoroizumiToshitsugu
en-aut-sei=Moroizumi
en-aut-mei=Toshitsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=hydrological modeling
kn-keyword=hydrological modeling
en-keyword=drought indices
kn-keyword=drought indices
en-keyword=drought features
kn-keyword=drought features
en-keyword=watershed scale assessment
kn-keyword=watershed scale assessment
en-keyword=agricultural activities
kn-keyword=agricultural activities
en-keyword=mountainous region
kn-keyword=mountainous region
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=5
article-no=
start-page=413
end-page=421
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Focal Cerebral Hypoperfusion Detected by Arterial Spin-Labeled Magnetic Resonance Imaging in Patients with Migraine Presenting with Neurological Symptoms Concomitant with or without Headache
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We investigated patients with migraine or migraine variants who exhibited focal cerebral hypoperfusion on arterial spin-labeled (ASL) magnetic resonance (MR) imaging along with neurological symptoms. Fourteen patients with migraine demonstrated focal cerebral hypoperfusion. Three other patients did not have a history of recurrent headaches but exhibited comparable cerebral hypoperfusion to migraine patients on ASL-MRI in addition to neurological symptoms. Patients with migraine may present with neurological symptoms associated with cortical spreading depression during, after, or even without a headache phase. Additionally, the isolated neurological symptoms may be caused by a pathophysiology identical to that of migraine but without presenting with recurrent headaches.
en-copyright=
kn-copyright=

en-aut-name=KashiharaKenichi
en-aut-sei=Kashihara
en-aut-mei=Kenichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IrisawaMinoru
en-aut-sei=Irisawa
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakaoWataru
en-aut-sei=Takao
en-aut-mei=Wataru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Okayama Neurology Clinic
kn-affil=

affil-num=2
en-affil=Department of Radiology, Okayama Kyokuto Hospital
kn-affil=

affil-num=3
en-affil=Division of Radiology, Okayama Kyokuto Hospital
kn-affil=
en-keyword=arterial spin-labeled magnetic resonance imaging
kn-keyword=arterial spin-labeled magnetic resonance imaging
en-keyword=cortical spreading depression
kn-keyword=cortical spreading depression
en-keyword=migraine complex
kn-keyword=migraine complex
en-keyword=migraine without headache
kn-keyword=migraine without headache
en-keyword=vertigo
kn-keyword=vertigo
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=5
article-no=
start-page=357
end-page=362
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Factors Affecting Dynamic Postural Control Ability in Adolescent Idiopathic Scoliosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Research on postural control in patients with adolescent idiopathic scoliosis (AIS) has focused on static postural control, with few studies assessing dynamic postural control. We aimed to identify factors affecting index of postural stability (IPS), a dynamic postural control parameter, in patients with AIS. The participants comprised 50 female patients with AIS. We measured the IPS using stabilometry to evaluate dynamic postural control ability. We investigated age of the participants, major curve position (thoracic or thoracolumbar/lumbar), Cobb angle, and coronal balance. We then assessed the relationships between stabilometry parameters and other variables. IPS was analyzed with a linear regression model. Coronal balance, major curve position, and age each correlated with dynamic postural control ability. The Cobb angle showed no correlation with any of the parameters. Our results offer new insights into the assessment of postural control in patients with AIS.
en-copyright=
kn-copyright=

en-aut-name=YamawakiRyoko
en-aut-sei=Yamawaki
en-aut-mei=Ryoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OdaYoshiaki
en-aut-sei=Oda
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamaneShuhei
en-aut-sei=Yamane
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UotaniKoji
en-aut-sei=Uotani
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MisawaHaruo
en-aut-sei=Misawa
en-aut-mei=Haruo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KatayamaYoshimi
en-aut-sei=Katayama
en-aut-mei=Yoshimi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HamadaMasanori
en-aut-sei=Hamada
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Division of Physical Medicine and Rehabilitation, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Division of Physical Medicine and Rehabilitation, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University
kn-affil=

affil-num=5
en-affil=Ryusoh Orthopaedic Hospital
kn-affil=

affil-num=6
en-affil=Division of Physical Medicine and Rehabilitation, Okayama University
kn-affil=

affil-num=7
en-affil=Division of Physical Medicine and Rehabilitation, Okayama University
kn-affil=

affil-num=8
en-affil=Division of Physical Medicine and Rehabilitation, Okayama University
kn-affil=
en-keyword=adolescent idiopathic scoliosis
kn-keyword=adolescent idiopathic scoliosis
en-keyword=postural control
kn-keyword=postural control
en-keyword=coronal balance
kn-keyword=coronal balance
en-keyword=index of postural stability
kn-keyword=index of postural stability
en-keyword=stabilometry
kn-keyword=stabilometry
END

start-ver=1.4
cd-journal=joma
no-vol=17
cd-vols=
no-issue=16
article-no=
start-page=4108
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240819
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of Scaffold Geometrical Structure on Macrophage Polarization during Bone Regeneration Using Honeycomb Tricalcium Phosphate
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The polarization balance of M1/M2 macrophages with different functions is important in osteogenesis and bone repair processes. In a previous study, we succeeded in developing honeycomb tricalcium phosphate (TCP), which is a cylindrical scaffold with a honeycomb arrangement of straight pores, and we demonstrated that TCP with 300 and 500 mu m pore diameters (300TCP and 500TCP) induced bone formation within the pores. However, the details of the influence of macrophage polarization on bone formation using engineered biomaterials, especially with respect to the geometric structure of the artificial biomaterials, are unknown. In this study, we examined whether differences in bone tissue formation due to differences in TCP geometry were due to the polarity of the assembling macrophages. Immunohistochemistry for IBA-1, iNOS, and CD163 single staining was performed. The 300TCP showed a marked infiltration of iNOS-positive cells, which are thought to be M1 macrophages, during the osteogenesis process, while no involvement of CD163-positive cells, which are thought to be M2 macrophages, was observed in the TCP pores. In addition, 500TCP showed a clustering of iNOS-positive cells and CD163-positive cells at 2 weeks, suggesting the involvement of M2 macrophages in the formation of bone tissue in the TCP pores. In conclusion, we demonstrated for the first time that the geometrical structure of the artificial biomaterial, i.e., the pore size of honeycomb TCP, affects the polarization of M1/2 macrophages and bone tissue formation in TCP pores.
en-copyright=
kn-copyright=

en-aut-name=TakabatakeKiyofumi
en-aut-sei=Takabatake
en-aut-mei=Kiyofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TsujigiwaHidetsugu
en-aut-sei=Tsujigiwa
en-aut-mei=Hidetsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakanoKeisuke
en-aut-sei=Nakano
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ChangAnqi
en-aut-sei=Chang
en-aut-mei=Anqi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=PiaoTianyan
en-aut-sei=Piao
en-aut-mei=Tianyan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=InadaYasunori
en-aut-sei=Inada
en-aut-mei=Yasunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ArashimaTakuma
en-aut-sei=Arashima
en-aut-mei=Takuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MorimatsuAyumi
en-aut-sei=Morimatsu
en-aut-mei=Ayumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TanakaAyumi
en-aut-sei=Tanaka
en-aut-mei=Ayumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Life Science, Faculty of Science, Okayama University of Science
kn-affil=

affil-num=3
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=honeycomb TCP
kn-keyword=honeycomb TCP
en-keyword=bone formation
kn-keyword=bone formation
en-keyword=macrophages
kn-keyword=macrophages
en-keyword=polarization
kn-keyword=polarization
END

start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=6
article-no=
start-page=1635
end-page=1642
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240719
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Pulmonary Flow Management by Combination Therapy of Hemostatic Clipping and Balloon Angioplasty for Right Ventricular-Pulmonary Artery Shunt in Hypoplastic Left Heart Syndrome
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Controlling pulmonary blood flow in patients who have undergone Norwood palliation, especially early postoperatively, is challenging due to a change in the balance of systemic and pulmonary vascular resistance. We applied a combination therapy of clipping and balloon angioplasty for right ventricle—pulmonary artery (RV-PA) shunt to control pulmonary blood flow, but the influence of the combination therapy on the PA condition is uncertain. Retrospectively analysis was conducted of all infants with hypoplastic left heart syndrome who had undergone Norwood palliation with RV-PA shunt at Okayama University Hospital from January 2008 to September 2022. A total of 50 consecutive patients underwent Norwood palliation with RV-PA shunt in this study period. Of them, 29 patients underwent RV-PA shunt flow clipping, and the remaining 21 had unclipped RV-PA shunt. Twenty-three patients underwent balloon angioplasty for RV-PA shunt with clips. After balloon angioplasty, oxygen saturation significantly increased from 69 (59–76)% to 80 (72–86)% (p < 0.001), and the narrowest portion of the clipped conduit significantly improved from 2.8 (1.8–3.4) to 3.8 (2.9–4.6) mm (p < 0.001). In cardiac catheterizations prior to Bidirectional cavo-pulmonary shunt (BCPS), there were no significant differences in pulmonary-to-systemic flow ratio (Qp/Qs), ventricular end-diastolic pressure, Nakata index, arterial saturation, mean pulmonary artery pressure and pulmonary vascular resistance index. On the other hand, in Cardiac catheterizations prior to Fontan, Nakata index was larger in the clipped group (p = 0.02). There was no statistically significant difference in the 5-year survival between the two groups (clipped group 96%, unclipped group 74%, log-rank test: p = 0.13). At least, our combination therapy of clipping and balloon angioplasty for RV-PA shunt did not negatively impact PA growth. Although there is a trend toward better but not statistically significant difference in outcomes in the clipped group compared to the non-clipped group, this treatment strategy may play an important role in improving outcomes in hypoplastic left heart syndrome.
en-copyright=
kn-copyright=

en-aut-name=ShigemitsuYusuke
en-aut-sei=Shigemitsu
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KondoMaiko
en-aut-sei=Kondo
en-aut-mei=Maiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KuritaYoshihiko
en-aut-sei=Kurita
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FukushimaYosuke
en-aut-sei=Fukushima
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawamotoYuya
en-aut-sei=Kawamoto
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HiraiKenta
en-aut-sei=Hirai
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HaraMayuko
en-aut-sei=Hara
en-aut-mei=Mayuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KanazawaTomoyuki
en-aut-sei=Kanazawa
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IwasakiTatsuo
en-aut-sei=Iwasaki
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KasaharaShingo
en-aut-sei=Kasahara
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KataokaKoichi
en-aut-sei=Kataoka
en-aut-mei=Koichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=TsukaharaHirokazu
en-aut-sei=Tsukahara
en-aut-mei=Hirokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=BabaKenji
en-aut-sei=Baba
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Pediatric Anesthesiology, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Pediatric Anesthesiology, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Pediatric Anesthesiology, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Cardiovascular Surgery, Okayama University Hospital
kn-affil=

affil-num=12
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=13
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=
en-keyword=Hypoplastic left heart syndrome
kn-keyword=Hypoplastic left heart syndrome
en-keyword=Norwood palliation
kn-keyword=Norwood palliation
en-keyword=Balloon angioplasty
kn-keyword=Balloon angioplasty
en-keyword=Congenital heart disease
kn-keyword=Congenital heart disease
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=13
article-no=
start-page=4293
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240701
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Optimizing IoT Intrusion Detection Using Balanced Class Distribution, Feature Selection, and Ensemble Machine Learning Techniques
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Internet of Things (IoT) devices are leading to advancements in innovation, efficiency, and sustainability across various industries. However, as the number of connected IoT devices increases, the risk of intrusion becomes a major concern in IoT security. To prevent intrusions, it is crucial to implement intrusion detection systems (IDSs) that can detect and prevent such attacks. IDSs are a critical component of cybersecurity infrastructure. They are designed to detect and respond to malicious activities within a network or system. Traditional IDS methods rely on predefined signatures or rules to identify known threats, but these techniques may struggle to detect novel or sophisticated attacks. The implementation of IDSs with machine learning (ML) and deep learning (DL) techniques has been proposed to improve IDSs' ability to detect attacks. This will enhance overall cybersecurity posture and resilience. However, ML and DL techniques face several issues that may impact the models' performance and effectiveness, such as overfitting and the effects of unimportant features on finding meaningful patterns. To ensure better performance and reliability of machine learning models in IDSs when dealing with new and unseen threats, the models need to be optimized. This can be done by addressing overfitting and implementing feature selection. In this paper, we propose a scheme to optimize IoT intrusion detection by using class balancing and feature selection for preprocessing. We evaluated the experiment on the UNSW-NB15 dataset and the NSL-KD dataset by implementing two different ensemble models: one using a support vector machine (SVM) with bagging and another using long short-term memory (LSTM) with stacking. The results of the performance and the confusion matrix show that the LSTM stacking with analysis of variance (ANOVA) feature selection model is a superior model for classifying network attacks. It has remarkable accuracies of 96.92% and 99.77% and overfitting values of 0.33% and 0.04% on the two datasets, respectively. The model's ROC is also shaped with a sharp bend, with AUC values of 0.9665 and 0.9971 for the UNSW-NB15 dataset and the NSL-KD dataset, respectively.
en-copyright=
kn-copyright=

en-aut-name=MusthafaMuhammad Bisri
en-aut-sei=Musthafa
en-aut-mei=Muhammad Bisri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HudaSamsul
en-aut-sei=Huda
en-aut-mei=Samsul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KoderaYuta
en-aut-sei=Kodera
en-aut-mei=Yuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AliMd. Arshad
en-aut-sei=Ali
en-aut-mei=Md. Arshad
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ArakiShunsuke
en-aut-sei=Araki
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MwauraJedidah
en-aut-sei=Mwaura
en-aut-mei=Jedidah
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NogamiYasuyuki
en-aut-sei=Nogami
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Green Innovation Center, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Faculty of CSE, Hajee Mohammad Danesh Science and Technology University
kn-affil=

affil-num=5
en-affil=Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology
kn-affil=

affil-num=6
en-affil=Graduate School of Computer Science and Systems Engineering, Kyushu Institute of Technology
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=
en-keyword=intrusion detection system
kn-keyword=intrusion detection system
en-keyword=feature selection
kn-keyword=feature selection
en-keyword=class balancing
kn-keyword=class balancing
en-keyword=ensemble technique
kn-keyword=ensemble technique
en-keyword=stacked long short-term memory
kn-keyword=stacked long short-term memory
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=3
article-no=
start-page=259
end-page=270
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202406
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Role of the Lipid Profile and Oxidative Stress in Fatigue, Sleep Disorders and Cognitive Impairment in Patients with Multiple Sclerosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this study is to investigate the relationship of the lipid profile, dysfunctional high-density lipoprotein, ischaemia-modified albumin and thiol–disulfide homeostasis with cognitive impairment, fatigue and sleep disorders in patients with multiple sclerosis. The cognitive functions of patients were evaluated with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Fatigue was evaluated with the Fatigue Severity Scale and the Fatigue Impact Scale. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used to assess patients’ sleep disturbance. Peripheral blood samples were collected, and lipid levels and myeloperoxidase and paraoxonase activity were measured. The myeloperoxidase/paraoxonase ratio, which indicates dysfunctional high-density lipoprotein, was calculated. Thiol–disulfide homeostasis and ischaemia-modified albumin were measured.<br>
We did not identify any relationship between dysfunctional high-density lipoprotein and the physical disability, cognitive decline, fatigue and sleep problems of multiple sclerosis. Thiol–disulfide homeostasis was associated with cognitive scores. The shift of the balance towards disulfide was accompanied by a decrease in cognitive scores. On the other hand, we did not detect any relationship between fatigue and sleep disorders and thiol–disulfide homeostasis. Our findings revealed a possible correlation between cognitive dysfunction and thiol–disulfide homeostasis in multiple sclerosis patients.
en-copyright=
kn-copyright=

en-aut-name=VuralGonul
en-aut-sei=Vural
en-aut-mei=Gonul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DemirEsra
en-aut-sei=Demir
en-aut-mei=Esra
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=GumusyaylaSadiye
en-aut-sei=Gumusyayla
en-aut-mei=Sadiye
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ErenFunda
en-aut-sei=Eren
en-aut-mei=Funda
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=BarakliSerdar
en-aut-sei=Barakli
en-aut-mei=Serdar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NeseliogluSalim
en-aut-sei=Neselioglu
en-aut-mei=Salim
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ErelOzcan
en-aut-sei=Erel
en-aut-mei=Ozcan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Neurology, Faculty of Medicine, Ankara Yildirim Beyazit University
kn-affil=

affil-num=2
en-affil=Department of Neurology, Ankara City Hospital
kn-affil=

affil-num=3
en-affil=Department of Neurology, Faculty of Medicine, Ankara Yildirim Beyazit University
kn-affil=

affil-num=4
en-affil=Department of Clinical Biochemistry, Ankara City Hospital
kn-affil=

affil-num=5
en-affil=Department of Neurology, Ankara City Hospital
kn-affil=

affil-num=6
en-affil=Department of Clinical Biochemistry, Ankara City Hospital
kn-affil=

affil-num=7
en-affil=Department of Clinical Biochemistry, Ankara City Hospital
kn-affil=
en-keyword=multiple sclerosis
kn-keyword=multiple sclerosis
en-keyword=dysfunctional HDL
kn-keyword=dysfunctional HDL
en-keyword=thiol–disulfide homeostasis
kn-keyword=thiol–disulfide homeostasis
en-keyword=cognitive decline
kn-keyword=cognitive decline
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=3
article-no=
start-page=251
end-page=258
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202406
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comparative Analysis of Thoracic Rotation Exercises: Range of Motion Improvement in Standing and Quadruped Variants
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=There have been few investigations into the effectiveness of thoracic spine exercises for improving thoracic range of motion (ROM) in any plane. This study assessed the effectiveness of two thoracic spine exercises: one in the quadruped position and one in the thoracic standing position. We determined how these exercises affect thoracic spine mobility ROM over a 2-week intervention period. Thirty-nine healthy participants were enrolled and assigned to a Quadruped Thoracic Rotation group (n=17 participants: 9 females and 8 males) or Flamenco Thoracic Spine Rotation group (n=22: 14 females and 8 males). All participants were administered a KOJI AWARENESSTM screening test, and the initial thoracic spine ROM before intervention exercise was measured in a laboratory setting. Quadruped Thoracic Rotation was performed as the quadruped exercise and Flamenco Thoracic Spine Rotation as the standing exercise. The KOJI AWARENESSTM thoracic spine test and ROM were evaluated on the day after the first exercise session and again after the program. Despite their different approaches to thoracic mobility, the quadruped exercise and standing exercise achieved equivalent improvement in thoracic ROM after 2 weeks. Practitioners have a range of exercise options for enhancing thoracic mobility based on their environmental or task-specific needs.
en-copyright=
kn-copyright=

en-aut-name=MurofushiKoji
en-aut-sei=Murofushi
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MitomoSho
en-aut-sei=Mitomo
en-aut-mei=Sho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HirohataKenji
en-aut-sei=Hirohata
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FuruyaHidetaka
en-aut-sei=Furuya
en-aut-mei=Hidetaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KatagiriHiroki
en-aut-sei=Katagiri
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KaneokaKoji
en-aut-sei=Kaneoka
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YagishitaKazuyoshi
en-aut-sei=Yagishita
en-aut-mei=Kazuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Sports Science Center, Tokyo Medical and Dental University (TMDU)
kn-affil=

affil-num=2
en-affil=Japan Sports Agency
kn-affil=

affil-num=3
en-affil=Clinical Center for Sports Medicine and Sports Dentistry, Tokyo Medical and Dental University (TMDU)
kn-affil=

affil-num=4
en-affil=Department of Rehabilitation, Sonoda Third Hospital/Tokyo Medical Institute Tokyo Spine Center
kn-affil=

affil-num=5
en-affil=Department of Orthopedics, Dokkyo Medical University Saitama Medical Center
kn-affil=

affil-num=6
en-affil=Faculty of Sport Science, Waseda University
kn-affil=

affil-num=7
en-affil=Clinical Center for Sports Medicine and Sports Dentistry, Tokyo Medical and Dental University (TMDU)
kn-affil=
en-keyword=thoracic spine
kn-keyword=thoracic spine
en-keyword=thoracic rotation range of motion
kn-keyword=thoracic rotation range of motion
en-keyword=exercise intervention
kn-keyword=exercise intervention
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=2
article-no=
start-page=185
end-page=191
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients.
en-copyright=
kn-copyright=

en-aut-name=TakahashiHiroko
en-aut-sei=Takahashi
en-aut-mei=Hiroko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=EguchiJun
en-aut-sei=Eguchi
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WatanabeMayu
en-aut-sei=Watanabe
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakayamaMasanori
en-aut-sei=Nakayama
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Office of Innovative Medicine, Organization for Research Strategy and Development, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=obesity
kn-keyword=obesity
en-keyword=type 2 diabetes
kn-keyword=type 2 diabetes
en-keyword=COVID-19
kn-keyword=COVID-19
en-keyword=vaccination
kn-keyword=vaccination
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=2
article-no=
start-page=151
end-page=161
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=p53-Armed Oncolytic Virotherapy Improves Radiosensitivity in Soft-Tissue Sarcoma by Suppressing BCL-xL Expression
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors.
en-copyright=
kn-copyright=

en-aut-name=KomatsubaraTadashi
en-aut-sei=Komatsubara
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TazawaHiroshi
en-aut-sei=Tazawa
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HaseiJoe
en-aut-sei=Hasei
en-aut-mei=Joe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OmoriToshinori
en-aut-sei=Omori
en-aut-mei=Toshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SugiuKazuhisa
en-aut-sei=Sugiu
en-aut-mei=Kazuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MochizukiYusuke
en-aut-sei=Mochizuki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=DemiyaKoji
en-aut-sei=Demiya
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YoshidaAki
en-aut-sei=Yoshida
en-aut-mei=Aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=FujiwaraTomohiro
en-aut-sei=Fujiwara
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KunisadaToshiyuki
en-aut-sei=Kunisada
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=UrataYasuo
en-aut-sei=Urata
en-aut-mei=Yasuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KagawaShunsuke
en-aut-sei=Kagawa
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Oncolys BioPharma, Inc.
kn-affil=

affil-num=12
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=soft-tissue sarcoma
kn-keyword=soft-tissue sarcoma
en-keyword=radiotherapy
kn-keyword=radiotherapy
en-keyword=oncolytic adenovirus
kn-keyword=oncolytic adenovirus
en-keyword=p53
kn-keyword=p53
en-keyword=BCL-xL
kn-keyword=BCL-xL
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=2
article-no=
start-page=95
end-page=106
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Roles of Neuropeptide Y in Respiratory Disease Pathogenesis via the Airway Immune Response
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases.
en-copyright=
kn-copyright=

en-aut-name=ItanoJunko
en-aut-sei=Itano
en-aut-mei=Junko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KiuraKatsuyuki
en-aut-sei=Kiura
en-aut-mei=Katsuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MiyaharaNobuaki
en-aut-sei=Miyahara
en-aut-mei=Nobuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital
kn-affil=
en-keyword=neuropeptide y
kn-keyword=neuropeptide y
en-keyword=Y1 receptor
kn-keyword=Y1 receptor
en-keyword=airway immune response
kn-keyword=airway immune response
en-keyword=bronchial epithelial cells
kn-keyword=bronchial epithelial cells
en-keyword=respiratory disease
kn-keyword=respiratory disease
END

start-ver=1.4
cd-journal=joma
no-vol=390
cd-vols=
no-issue=3
article-no=
start-page=3931
end-page=3967
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240405
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Entire solutions with and without radial symmetry in balanced bistable reaction–diffusion equations
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Let n ≥ 2 be a given integer. In this paper, we assert that an n-dimensional traveling front converges to an (n−1)-dimensional entire solution as the speed goes to infinity in a balanced bistable reaction–diffusion equation. As the speed of an n-dimensional axially symmetric or asymmetric traveling front goes to infinity, it converges to an (n−1)-dimensional radially symmetric or asymmetric entire solution in a balanced bistable reaction–diffusion equation, respectively. We conjecture that the radially asymmetric entire solutions obtained in this paper are associated with the ancient solutions called the Angenent ovals in the mean curvature flows.
en-copyright=
kn-copyright=

en-aut-name=TaniguchiMasaharu
en-aut-sei=Taniguchi
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202402
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Role of Macrophages in Liver Fibrosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and plasticity and include tissue-resident macrophages termed Kupffer cells, and recruited macrophages derived from circulating monocytes, spleen and peritoneal cavity. Studies have shown that hepatic macrophages play roles in the initiation and progression of liver fibrosis by releasing inflammatory cytokines/chemokines and pro-fibrogenic factors. Furthermore, the development of liver fibrosis has been shown to be reversible. Hepatic macrophages have been shown to alternately regulate both the regression and turnover of liver fibrosis by changing their phenotypes during the dynamic progression of liver fibrosis. In this review, we summarize the role of hepatic macrophages in the progression and regression of liver fibrosis.
en-copyright=
kn-copyright=

en-aut-name=SunCuiming
en-aut-sei=Sun
en-aut-mei=Cuiming
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsukawaAkihiro
en-aut-sei=Matsukawa
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Pathology and Experimental Medicine, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Pathology and Experimental Medicine, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=ERK-MAPK
kn-keyword=ERK-MAPK
en-keyword=SPRED2
kn-keyword=SPRED2
en-keyword=fibrosis
kn-keyword=fibrosis
en-keyword=macrophages
kn-keyword=macrophages
END

start-ver=1.4
cd-journal=joma
no-vol=113
cd-vols=
no-issue=
article-no=
start-page=1
end-page=6
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evaluator of adaptability of S. cerevisiae to grape juice using the oversxpression profiling ADOPT method
kn-title=過剰発現プロファイリングADOPT法を用いたS.cerevisiaeのワイン醸造用ブドウ果汁への適応性評価
en-subtitle=
kn-subtitle=
en-abstract=筆者らは最近，過剰発現プロファイリングADOPT 法を開発した．ADOPT 法では，出芽酵母Saccharomyces cerevisiae ゲノムのほとんどの遺伝子をそれぞれ過剰発現する酵母株を混合・競合培養し，その過程で濃縮されてきた株が過剰発現している遺伝子を体系的に同定する．さらに同定された遺伝子をたよりに，S. cerevisiae の与えられた条件での増殖に必要だが欠落しているボトルネック因子を明らかにできる．これまでの研究では，実験室で人為的に構築したストレス環境でのボトルネックの同定を行ってきたが，本研究では産業上のボトルネックを明らかにできるかをワイン醸造用のブドウ果汁を例として検証した．通常のワイン醸造に用いられる亜硫酸添加ブドウ果汁でのADOPT 実験は，亜硫酸ポンプSSU1とその転写因子FZF1の過剰発現株が強く濃縮された．SSU1機能の強化はワイン用酵母の馴養でも起きることが知られていることから，産業上のボトルネックを探索する際にもADOPT が有効であることが示された．一方，亜硫酸添加のないブドウ果汁ではADOPT で強く濃縮された遺伝子は見られず，ブドウ果汁はS. cerevisiae の増殖にとってボトルネックの少ないバランスのとれた培地であることが示唆された．
kn-abstract=The authors have recently developed the overexpression profiling ADOPT method. In the ADOPT method, yeast strains overexpressing most of the genes in the budding yeast Saccharomyces cerevisiae genome are mixed and competitively cultured, and the genes overexpressed in the enriched strains are systematically identified. Furthermore, the identified genes can be used to identify bottleneck factors that are necessary but lacking for growth of S. cerevisiae under given conditions. In our previous studies, we have identified bottlenecks in artificially created stress environments in the laboratory, but in this study, we used grape juice for winemaking as an example to see if industrial bottlenecks can be identified. ADOPT experiments with sulfite-added grape juice used in conventional winemaking resulted in a strong enrichment of strains overexpressing the sulfite pump SSU1 and its transcription factor FZF1. Since enhancement of SSU1 function is known to occur in wine yeast acclimation, ADOPT was also shown to be useful in the search for industrial bottlenecks. On the other hand, no genes were strongly enriched by ADOPT in grape juice without sulfite addition, suggesting that grape juice is a balanced medium with few bottlenecks for S. cerevisiae growth.
en-copyright=
kn-copyright=

en-aut-name=MoriyaHisao
en-aut-sei=Moriya
en-aut-mei=Hisao
kn-aut-name=守屋央朗
kn-aut-sei=守屋
kn-aut-mei=央朗
aut-affil-num=1
ORCID=

en-aut-name=OnoChiyuki Kohata 
en-aut-sei=Ono
en-aut-mei=Chiyuki Kohata 
kn-aut-name=小野千由貴
kn-aut-sei=小野
kn-aut-mei=千由貴
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Course of Agrochemical Bioscience
kn-affil=農芸化学コース

affil-num=2
en-affil=Course of Agrochemical Bioscience
kn-affil=農芸化学コース
en-keyword=yeast
kn-keyword=yeast
en-keyword=S. cerevisiae
kn-keyword=S. cerevisiae
en-keyword=overexpression
kn-keyword=overexpression
en-keyword=wine making
kn-keyword=wine making
END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=1
article-no=
start-page=71
end-page=75
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230913
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Aggregation pheromone interrupts death feigning in the red flour beetle Tribolium castaneum
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Death feigning is a behavior in which a prey is rendered motionless due to stimulation or threat by a predator. This anti-predator defense mechanism has been observed across a wide range of animal taxa and is considered adaptive. However, long durations of death feigning can decrease opportunities for feeding and reproduction, and therefore is a fitness cost as compared to environments without predators. Because death feigning is thought to be affected by the balance between survival and other fitness costs, selection pressure may drive individuals who are capable of plastic changes in the intensity of death feigning. Pheromones, which are important semiochemicals that affect foraging and reproductive success, may be one of the factors influencing the intensity of death-feigning behavior. In this study, we investigated the effect of an aggregation pheromone on the death-feigning behavior of the red flour beetle Tribolium castaneum. We found that beetles exposed to the pheromone showed a significantly shorter duration of death feigning than beetles that were not exposed to the pheromone. Therefore, our results suggest that an aggregation pheromone can plasticly alter the death-feigning behavior in T. castaneum.
en-copyright=
kn-copyright=

en-aut-name=IshikawaMotoya
en-aut-sei=Ishikawa
en-aut-mei=Motoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Anti-predator strategies
kn-keyword=Anti-predator strategies
en-keyword=Death feigning
kn-keyword=Death feigning
en-keyword=Aggregation pheromone
kn-keyword=Aggregation pheromone
en-keyword=Sexual selection
kn-keyword=Sexual selection
en-keyword=Tribolium castaneum
kn-keyword=Tribolium castaneum
END

start-ver=1.4
cd-journal=joma
no-vol=63
cd-vols=
no-issue=7
article-no=
start-page=e80
end-page=e85
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220528
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Novel animal model of combined generalized and focal epilepsy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Thioredoxin, encoded by Txn1, is a critical antioxidant that protects against oxidative damage by regulating the dithiol/disulfide balance of interacting proteins. We recently discovered the Adem rat, an epileptic rat harboring the Txn1-F54L mutation, characterized by wild running and vacuolar degeneration in the midbrain. This study aimed to characterize the classification of epilepsy in Adem rats. We performed simultaneous video-electroencephalographic recordings, magnetic resonance imaging, neurotransmitter measurements using gas chromatography–mass spectrometry (GC-MS), and immunohistochemistry. Adem rats exhibited absence, tonic, and focal seizures. The type of epilepsy was classified as combined generalized and focal epilepsy. Neurotransmitters in the midbrain and cortex were measured at 3 weeks of age, when neuronal cell death occurs in the midbrain. The results of GC-MS ruled out the dominance of the excitatory system in the midbrain and cortex of Adem rats. Activation of astrocytes and microglia was more pronounced at 5 weeks of age, at which time epileptic seizures occurred frequently. The underlying pathology in Adem rats remains unknown. However, glial cell activation and inflammation may play a significant role in the occurrence of epilepsy.
en-copyright=
kn-copyright=

en-aut-name=OhmoriIori
en-aut-sei=Ohmori
en-aut-mei=Iori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OuchidaMamoru
en-aut-sei=Ouchida
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShinoharaMasakazu
en-aut-sei=Shinohara
en-aut-mei=Masakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KobayashiKiyoka
en-aut-sei=Kobayashi
en-aut-mei=Kiyoka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IshidaSaeko
en-aut-sei=Ishida
en-aut-mei=Saeko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MashimoTomoji
en-aut-sei=Mashimo
en-aut-mei=Tomoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Section of Developmental Physiology and Pathology, Faculty of Education, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Molecular Oncology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Division of Epidemiology, Kobe University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Otsuka Pharmaceutical
kn-affil=

affil-num=5
en-affil=Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo
kn-affil=

affil-num=6
en-affil=Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo
kn-affil=
en-keyword=animal model
kn-keyword=animal model
en-keyword=combined generalized and focal epilepsy
kn-keyword=combined generalized and focal epilepsy
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=thioredoxin
kn-keyword=thioredoxin
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=15
article-no=
start-page=5677
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230728
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Features and Evolution of Global Energy Trade Patterns from the Perspective of Complex Networks
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=As an integral part of economic trade, energy trade is crucial to international dynamics and national interests. In this study, an international energy trade network is constructed by abstracting countries as nodes and representing energy trade relations as edges. A variety of indicators are designed in terms of networks, nodes, bilaterals, and communities to analyze the temporal and spatial evolution of the global energy trade network from 2001 to 2020. The results indicate that network density and strength have been steadily increasing since the beginning of the 21st century. It is observed that the position of the United States as the core of the international energy market is being impacted by emerging developing countries, thus affecting the existing trade balance based on topological analysis. The weighted analysis of bilateral relations demonstrates that emerging countries such as China, Brazil, and Saudi Arabia are pursuing closer cooperation. The community analysis reveals that an increasing number of countries possess strong energy trade capabilities, resulting in a corresponding increase in energy trade volumes.
en-copyright=
kn-copyright=

en-aut-name=CongYingnan
en-aut-sei=Cong
en-aut-mei=Yingnan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HouYufei
en-aut-sei=Hou
en-aut-mei=Yufei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=JiangJiaming
en-aut-sei=Jiang
en-aut-mei=Jiaming
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ChenShuangzi
en-aut-sei=Chen
en-aut-mei=Shuangzi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=CaiXiaojing
en-aut-sei=Cai
en-aut-mei=Xiaojing
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Business School, China University of Political Science and Law
kn-affil=

affil-num=2
en-affil=Business School, China University of Political Science and Law
kn-affil=

affil-num=3
en-affil=Center for Artificial Intelligence and Mathematical Data Science, Okayama University
kn-affil=

affil-num=4
en-affil=School of Economics, Hebei University
kn-affil=

affil-num=5
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=
en-keyword=energy trade
kn-keyword=energy trade
en-keyword=complex networks
kn-keyword=complex networks
en-keyword=topology
kn-keyword=topology
en-keyword=evolutionary properties
kn-keyword=evolutionary properties
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=15
article-no=
start-page=5028
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evidence for Hypoxia-Induced Shift in ATP Production from Glycolysis to Mitochondrial Respiration in Pulmonary Artery Smooth Muscle Cells in Pulmonary Arterial Hypertension
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: The metabolic state of pulmonary artery smooth muscle cells (PASMCs) from patients with pulmonary arterial hypertension (PAH) is not well understood. In this study, we examined the balance between glycolysis and mitochondrial respiration in non-PAH-PASMCs and PAH-PASMCs under normoxia and hypoxia. Methods: We investigated the enzymes involved in glycolysis and mitochondrial respiration, and studied the two major energy-yielding pathways (glycolysis and mitochondrial respiration) by measuring extracellular acidification rate (ECAR) and cellular oxygen consumption rate (OCR) using the Seahorse extracellular flux technology. Results: Under both normoxia and hypoxia, the mRNA and protein levels of pyruvate dehydrogenase kinase 1 and pyruvate dehydrogenase were increased in PAH-PASMCs compared with non-PAH-PASMCs. The mRNA and protein levels of lactate dehydrogenase, as well as the intracellular lactate concentration, were also increased in PAH-PASMCs compared with non-PAH-PASMCs under normoxia. However, these were not significantly increased in PAH-PASMCs compared with non-PAH-PASMCs under hypoxia. Under normoxia, ATP production was significantly lower in PAH-PASMCs (59 ± 5 pmol/min) than in non-PAH-PASMCs (70 ± 10 pmol/min). On the other hand, ATP production was significantly higher in PAH-PASMCs (31 ± 5 pmol/min) than in non-PAH-PASMCs (14 ± 3 pmol/min) under hypoxia. Conclusions: There is an underlying change in the metabolic strategy to generate ATP production under the challenge of hypoxia.
en-copyright=
kn-copyright=

en-aut-name=AkagiSatoshi
en-aut-sei=Akagi
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraKazufumi
en-aut-sei=Nakamura
en-aut-mei=Kazufumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KondoMegumi
en-aut-sei=Kondo
en-aut-mei=Megumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HirohataSatoshi
en-aut-sei=Hirohata
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=UdonoHeiichiro
en-aut-sei=Udono
en-aut-mei=Heiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NishidaMikako
en-aut-sei=Nishida
en-aut-mei=Mikako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SaitoYukihiro
en-aut-sei=Saito
en-aut-mei=Yukihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YoshidaMasashi
en-aut-sei=Yoshida
en-aut-mei=Masashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MiyoshiToru
en-aut-sei=Miyoshi
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ItoHiroshi
en-aut-sei=Ito
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Immunology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Immunology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=glycolysis
kn-keyword=glycolysis
en-keyword=mitochondrial respiration
kn-keyword=mitochondrial respiration
en-keyword=pulmonary arterial hypertension
kn-keyword=pulmonary arterial hypertension
en-keyword=pulmonary artery smooth muscle cells
kn-keyword=pulmonary artery smooth muscle cells
en-keyword=Seahorse technology
kn-keyword=Seahorse technology
en-keyword=hypoxia
kn-keyword=hypoxia
en-keyword=ATP production
kn-keyword=ATP production
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=4
article-no=
start-page=395
end-page=405
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Association of Tumor Necrosis Factor-Alpha with Psychopathology in Patients with Schizophrenia
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia.
en-copyright=
kn-copyright=

en-aut-name=PavlovicMarko
en-aut-sei=Pavlovic
en-aut-mei=Marko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=BabicDragan
en-aut-sei=Babic
en-aut-mei=Dragan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=RastovicPejana
en-aut-sei=Rastovic
en-aut-mei=Pejana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ArapovicJurica
en-aut-sei=Arapovic
en-aut-mei=Jurica
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MartinacMarko
en-aut-sei=Martinac
en-aut-mei=Marko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=JakovacSanja
en-aut-sei=Jakovac
en-aut-mei=Sanja
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=BarbaricRomana
en-aut-sei=Barbaric
en-aut-mei=Romana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=University Hospital Center Mostar, University of Mostar
kn-affil=

affil-num=2
en-affil=University Hospital Center Mostar, University of Mostar
kn-affil=

affil-num=3
en-affil=University Hospital Center Mostar, University of Mostar
kn-affil=

affil-num=4
en-affil=University Hospital Center Mostar, University of Mostar
kn-affil=

affil-num=5
en-affil=Health Care Center Mostar, University of Mostar
kn-affil=

affil-num=6
en-affil=University Hospital Center Mostar, University of Mostar
kn-affil=

affil-num=7
en-affil=University Hospital Center Mostar, University of Mostar
kn-affil=
en-keyword=tumor necrosis factor-alpha
kn-keyword=tumor necrosis factor-alpha
en-keyword=schizophrenia
kn-keyword=schizophrenia
en-keyword=psychopathology
kn-keyword=psychopathology
en-keyword=immune system
kn-keyword=immune system
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=918273
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220718
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Sea Surface Temperature and Salinity in Lombok Strait Reconstructed From Coral Sr/Ca and δ18O, 1962–2012
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Coral geochemical tracers have been used in studies of the paleoclimatology and paleoceanography of the tropics and subtropics. We measured Sr/Ca and oxygen isotope ratios (δ18O) in a coral sample collected from the southern part of Lombok Strait, a significant outlet of the Indonesian Throughflow (ITF) to the Indian Ocean, to reconstruct the historical record of sea surface temperature (SST) and seawater δ18O. Seawater δ18O can be used to approximate sea surface salinity (SSS) because it reflects the balance of evaporation and precipitation. The resulting time series reconstructed SST and SSS, covering the period 1962–2012, shows no clear trend of global warming, although the record includes a large cooling event (~4°C) during 1996–1997. Although neither SST nor SSS shows a systematic relationship with El Niño–Southern Oscillation and Indian Ocean Dipole (IOD), weak but significant correlations are found partly. In addition, the coral data show signals of major IOD and El Niño events in 1994 and 1997, respectively, although climatic trends recorded in the coral are not consistent with those found along the Java-Sumatra coast. To evaluate other influences on the ITF in Lombok Strait, we compared our coral record with coral records from sites in the Java Sea, the southern part of Makassar Strait, and Ombai Strait. During the northwest monsoon (December–January–February), variations in SST and SSS at Lombok Strait site are similar to those at the Java Sea and southern Makassar sites for the period 1962–1995, which suggests that low-salinity water from the Java Sea is carried at least to the southern part of Makassar Strait where it suppresses the ITF upstream from Lombok Strait. However, the SST and SSS records differ at the three sites during the southeast monsoon (June–July–August), indicating that surface conditions in Lombok Strait vary separately from those in the Java Sea. In the longer term, although global warming has been widely identified in the Indonesian Seas, the coral record shows no clear warming trend in the southern part of Lombok Strait, where fluctuations in the ITF may be modulating the distribution of heat in the surface waters of the western Pacific and eastern Indian Ocean.
en-copyright=
kn-copyright=

en-aut-name=GendaAi
en-aut-sei=Genda
en-aut-mei=Ai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IkeharaMinoru
en-aut-sei=Ikehara
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuzukiAtsushi
en-aut-sei=Suzuki
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ArmanAli
en-aut-sei=Arman
en-aut-mei=Ali
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=InoueMayuri
en-aut-sei=Inoue
en-aut-mei=Mayuri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Center for Advanced Marine Core Research, Kochi University
kn-affil=

affil-num=3
en-affil=Geological Survey of Japan, National Institute of Advanced Industrial Science and Technology (AIST)
kn-affil=

affil-num=4
en-affil=Research and Technology Center for Application of Isotope and Radiation, National Research and Innovation Agency
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=coral
kn-keyword=coral
en-keyword=geochemical tracers
kn-keyword=geochemical tracers
en-keyword=Sr/Ca
kn-keyword=Sr/Ca
en-keyword=δ 18O
kn-keyword=δ 18O
en-keyword=sea surface temperature
kn-keyword=sea surface temperature
en-keyword=salinity
kn-keyword=salinity
en-keyword=Lombok Strait
kn-keyword=Lombok Strait
END

start-ver=1.4
cd-journal=joma
no-vol=34
cd-vols=
no-issue=8
article-no=
start-page=2955
end-page=2971
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220802
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Method for Estimating Physician Stress Using Wearable Sensor Devices
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The idea of Society 5.0 initiative has been proposed to solve various social problems by connecting virtual cyberspace and real physical space through information technology. When applying the idea to improve the work-life balance of physicians in the medical field, we must consider the increased stress owing to their long continuous working hours. Estimating the stress of physicians in their daily lives by the questionnaires is insufficient, because of the difficulty of accurate their activity recalling. By using bio-metric information such as heart rate, physical activity, and sleeping information, it was expected that the daily stress state of physicians with high accuracy. In this paper, we propose a method for estimating physician stress by analyzing bio-metric information acquired by wearing a wearable sensor device. The proposed method estimates the state of stress during daily activities by acquiring data on heart rate variability (HRV) during wakefulness as well as sleep depth during rapid eye movement (REM) and non-REM sleep. Up to seven physicians wore the wearable sensor device for the maximum of eight weeks and the sleep depth and low-/high-frequency (LF/HF) components of HRV were obtained. Our observation showed that physicians' root mean square of successive differences (rMSSDs) were constantly high in their healthy state. Therefore, the decreasing of this index can be used as an indicator of fatigue and stress. In addition, by combining LF/HF components to the rMSSDs, we may estimate the stress state of physicians and find personal stressors.
en-copyright=
kn-copyright=

en-aut-name=ImuraIssei
en-aut-sei=Imura
en-aut-mei=Issei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=GotohYusuke
en-aut-sei=Gotoh
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SakaiKoji
en-aut-sei=Sakai
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OharaYu
en-aut-sei=Ohara
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TazoeJun
en-aut-sei=Tazoe
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiuraHiroshi
en-aut-sei=Miura
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HirotaTatsuya
en-aut-sei=Hirota
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=UchiyamaAkira
en-aut-sei=Uchiyama
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NomuraYoshinari
en-aut-sei=Nomura
en-aut-mei=Yoshinari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Faculty of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Radiology, Kyoto Prefectural University of Medicine
kn-affil=

affil-num=4
en-affil=Department of Radiology, Kyoto Prefectural University of Medicine
kn-affil=

affil-num=5
en-affil=Department of Radiology, Kyoto Prefectural University of Medicine
kn-affil=

affil-num=6
en-affil=Department of Radiology, Kyoto Prefectural University of Medicine
kn-affil=

affil-num=7
en-affil=Department of Radiology, Kyoto Prefectural University of Medicine
kn-affil=

affil-num=8
en-affil=Graduate School of Information Science and Technology, Osaka University
kn-affil=

affil-num=9
en-affil=Faculty of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=heart rate variability
kn-keyword=heart rate variability
en-keyword=LF/HF
kn-keyword=LF/HF
en-keyword=Society 5.0
kn-keyword=Society 5.0
en-keyword=stress
kn-keyword=stress
en-keyword=wearable sensor devices
kn-keyword=wearable sensor devices
en-keyword=working style
kn-keyword=working style
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=1
article-no=
start-page=596
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230602
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=NFYA promotes malignant behavior of triple-negative breast cancer in mice through the regulation of lipid metabolism
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Two splicing variants exist in NFYA that exhibit high expression in many human tumour types. The balance in their expression correlates with prognosis in breast cancer, but functional differences remain unclear. Here, we demonstrate that NFYAv1, a long-form variant, upregulates the transcription of essential lipogenic enzymes ACACA and FASN to enhance the malignant behavior of triple-negative breast cancer (TNBC). Loss of the NFYAv1-lipogenesis axis strongly suppresses malignant behavior in vitro and in vivo, indicating that the NFYAv1-lipogenesis axis is essential for TNBC malignant behavior and that the axis might be a potential therapeutic target for TNBC. Furthermore, mice deficient in lipogenic enzymes, such as Acly, Acaca, and Fasn, exhibit embryonic lethality; however, Nfyav1-deficient mice exhibited no apparent developmental abnormalities. Our results indicate that the NFYAv1-lipogenesis axis has tumour-promoting effects and that NFYAv1 may be a safe therapeutic target for TNBC.
en-copyright=
kn-copyright=

en-aut-name=OkadaNobuhiro
en-aut-sei=Okada
en-aut-mei=Nobuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UekiChihiro
en-aut-sei=Ueki
en-aut-mei=Chihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShimazakiMasahiro
en-aut-sei=Shimazaki
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TsujimotoGoki
en-aut-sei=Tsujimoto
en-aut-mei=Goki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KohnoSusumu
en-aut-sei=Kohno
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MuranakaHayato
en-aut-sei=Muranaka
en-aut-mei=Hayato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YoshikawaKiyotsugu
en-aut-sei=Yoshikawa
en-aut-mei=Kiyotsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakahashiChiaki
en-aut-sei=Takahashi
en-aut-mei=Chiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science & Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science & Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Laboratory for Malignancy Control Research, Medical Innovation Center, Kyoto University
kn-affil=

affil-num=4
en-affil=Graduate School of Interdisciplinary Science & Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University
kn-affil=

affil-num=6
en-affil=Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University
kn-affil=

affil-num=7
en-affil=Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts
kn-affil=

affil-num=8
en-affil=Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=3
article-no=
start-page=301
end-page=309
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Associations between Comorbidities and Acute Exacerbation of Interstitial Lung Disease after Primary Lung Cancer Surgery
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Acute exacerbation (AE) of interstitial lung disease (ILD) is a severe complication of lung resection in lung cancer patients with ILD (LC-ILD). This study aimed to assess the predictive value of comorbidities other than ILD for postoperative AE in patients with LC-ILD. We retrospectively evaluated 68 patients with LC-ILD who had undergone lung resection. We classified them into two groups: those who had developed postoperative AE within 30 days after resection and those who had not. We analyzed patient characteristics, high-resolution computed tomography findings, clinical data, pulmonary function, and intraoperative data. The incidence of postoperative AEs was 11.8%. In univariate analysis, performance status (PS), honeycombing, forced vital capacity (FVC), and high hemoglobin A1c (HbA1c) levels without comorbidities were significantly associated with postoperative AE. Patients were divided into two groups according to cutoff levels of those four variables as determined by receiver operating characteristic curves, revealing that the rates of patients without postoperative AE differed significantly between groups. The present results suggested that preoperative comorbidities other than ILD were not risk factors for postoperative AE in patients with LC-ILD. However, a high preoperative HbA1c level, poor PS, low FVC, and honeycombing may be associated with postoperative AE of LC-ILD.
en-copyright=
kn-copyright=

en-aut-name=KatoTakahide
en-aut-sei=Kato
en-aut-mei=Takahide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyoshiSeigo
en-aut-sei=Miyoshi
en-aut-mei=Seigo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HamadaChizuru
en-aut-sei=Hamada
en-aut-mei=Chizuru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SanoYoshifumi
en-aut-sei=Sano
en-aut-mei=Yoshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NogamiNaoyuki
en-aut-sei=Nogami
en-aut-mei=Naoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamaguchiOsamu
en-aut-sei=Yamaguchi
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HamaguchiNaohiko
en-aut-sei=Hamaguchi
en-aut-mei=Naohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine
kn-affil=

affil-num=5
en-affil=Department of Community Medicine, Pulmonology and Cardiology, Ehime University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine
kn-affil=
en-keyword=lung cancer
kn-keyword=lung cancer
en-keyword=interstitial lung disease
kn-keyword=interstitial lung disease
en-keyword=acute exacerbation
kn-keyword=acute exacerbation
en-keyword=comorbidity
kn-keyword=comorbidity
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=3
article-no=
start-page=263
end-page=272
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Early Fluid Balance Is Associated with 90-Day Mortality in Patients Receiving Continuous Renal Replacement Therapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Continuous renal replacement therapy (CRRT) is widely used to control fluid balance, but the optimal fluid balance to improve the prognosis of patients remains debated. Appropriate fluid management may depend on hemodynamic status. We investigated the association between 90-day mortality and fluid balance/mean arterial pressure (MAP) in patients receiving CRRT. This single-center retrospective study was conducted between May 2018 and March 2021. Based on the cumulative fluid balance at 72 h after initiation of CRRT, the cases were divided into negative (< 0 mL) and positive (> 0 mL) fluid balance groups. Ninety-day mortality was higher in the positive fluid balance group (p=0.009). At 4 h before and after CRRT initiation, the mean MAP was lower in the positive fluid balance group (p<0.05). After multivariate cox adjustment, 72-h positive fluid balance was independently associated with 90-day mortality (p=0.004). In addition, the cumulative fluid balance was associated with 90-day mortality (p<0.05) in cases without shock, high APACHE II score, sepsis, dialysis dependence, or vasopressor use. A 72-h positive fluid balance was associated with 90-day mortality in patients receiving CRRT.
en-copyright=
kn-copyright=

en-aut-name=GuoYusheng
en-aut-sei=Guo
en-aut-mei=Yusheng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KosakaJunko
en-aut-sei=Kosaka
en-aut-mei=Junko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MorimatsuHiroshi
en-aut-sei=Morimatsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=fluid management
kn-keyword=fluid management
en-keyword=continuous renal replacement therapy
kn-keyword=continuous renal replacement therapy
en-keyword=mortality
kn-keyword=mortality
en-keyword=mean arterial pressure
kn-keyword=mean arterial pressure
en-keyword=daily cumulative fluid balance
kn-keyword=daily cumulative fluid balance
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=3
article-no=
start-page=243
end-page=254
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Brown Adipose Tissue PPARγ Is Required for the Insulin-Sensitizing Action of Thiazolidinediones
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Brown adipose tissue (BAT) plays a critical role in metabolic homeostasis. BAT dysfunction is associated with the development of obesity through an imbalance between energy expenditure and energy intake. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulator of adipogenesis. However, the roles of PPARγ and thiazolidinediones (TZDs) in the regulation of BAT metabolism remain unclear. TZDs, which are selective PPARγ activators, improve systemic insulin resistance in animals and humans. In the present study, we generated brown adipocyte-specific PPARγ-deficient mice (BATγKO) to examine the in vivo roles of PPARγ and TZDs in BAT metabolism. In electron microscopic examinations, brown adipocyte-specific PPARγ deletion promoted severe whitening of brown fat and morphological alteration of mitochondria. Brown adipocyte-specific PPARγ deletion also reduced mRNA expression of BAT-selective genes. Although there was no difference in energy expenditure between control and BATγKO mice in calorimetry, norepinephrine-induced thermogenesis was impaired in BATγKO mice. Moreover, pioglitazone treatment improved diet-induced insulin resistance in the control mice but not in the BATγKO mice. These findings suggest that BAT PPARγ is necessary for the maintenance of brown adipocyte function and for the insulin-sensitizing action of TZDs.
en-copyright=
kn-copyright=

en-aut-name=ShibataYusuke
en-aut-sei=Shibata
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=EguchiJun
en-aut-sei=Eguchi
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=PPARγ
kn-keyword=PPARγ
en-keyword=brown adipose tissue
kn-keyword=brown adipose tissue
en-keyword=thiazolidinediones
kn-keyword=thiazolidinediones
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=持続的腎代替療法施行患者における治療開始後早期の水分バランスと90日死亡率についての検討
kn-title=Early fluid balance is associated with 90-day mortality in patients receiving continuous renal replacement therapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=GUOYUSHENG
en-aut-sei=GUO
en-aut-mei=YUSHENG
kn-aut-name=郭 豫晟
kn-aut-sei=郭
kn-aut-mei= 豫晟
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=175
cd-vols=
no-issue=
article-no=
start-page=105921
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Thioredoxin deficiency increases oxidative stress and causes bilateral symmetrical degeneration in rat midbrain
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Thioredoxin, encoded by Txn1, acts as a critical antioxidant in the defense against oxidative stress by regulating the dithiol/disulfide balance of interacting proteins. The role of thioredoxin in the central nervous system (CNS) is largely unknown. A phenotype-driven study of N-ethyl-N-nitrosourea-mutated rats with wild-running seizures revealed the importance of Txn1 mutations in CNS degeneration. Genetic mapping identified Txn1-F54L in the epileptic rats. The insulin-reducing activity of Txn1-F54L was approximately one-third of that of the wild-type (WT). Bilateral symmetrical vacuolar degeneration in the midbrain, mainly in the thalamus and the inferior colliculus, was observed in the Txn1-F54L rats. The lesions displayed neuronal and oligodendrocytic cell death. Neurons in Txn1-F54L rats showed morphological changes in the mitochondria. Vacuolar degeneration peaked at five weeks of age, and spontaneous repair began at seven weeks. The TUNEL assay showed that fibroblasts derived from homozygotes were susceptible to cell death under oxidative stress. In five-week-old WT rats, energy metabolism in the thalamus was significantly higher than that in the cerebral cortex. In conclusion, in juvenile rats, Txn1 seems to play an essential role in reducing oxidative stress in the midbrains with high energy metabolism.
en-copyright=
kn-copyright=

en-aut-name=OhmoriIori
en-aut-sei=Ohmori
en-aut-mei=Iori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OuchidaMamoru
en-aut-sei=Ouchida
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ImaiHirohiko
en-aut-sei=Imai
en-aut-mei=Hirohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshidaSaeko
en-aut-sei=Ishida
en-aut-mei=Saeko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ToyokuniShinya
en-aut-sei=Toyokuni
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MashimoTomoji
en-aut-sei=Mashimo
en-aut-mei=Tomoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Section of Developmental Physiology and Pathology, Faculty of Education, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Molecular Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Systems Science, Kyoto University Graduate School of Informatics
kn-affil=

affil-num=4
en-affil=Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo
kn-affil=

affil-num=5
en-affil=Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo
kn-affil=
en-keyword=Txn1
kn-keyword=Txn1
en-keyword=Thioredoxin
kn-keyword=Thioredoxin
en-keyword=Mitochondria
kn-keyword=Mitochondria
en-keyword=Vacuolar degeneration
kn-keyword=Vacuolar degeneration
en-keyword=Epilepsy
kn-keyword=Epilepsy
en-keyword=Oxidative stress
kn-keyword=Oxidative stress
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=
article-no=
start-page=83
end-page=97
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Awareness of Parental Support in Light of the Dual Roles of a Nursery Teacher and a Parent
kn-title=保育士と親の二重役割から見た保護者支援に対する意識
en-subtitle=
kn-subtitle=
en-abstract=This study examined the relationships of the mutual influence of the dual roles of a parent and a nursery teacher who has childrearing experience on the professional competence of nursery teachers in providing parental support concerning childrearing and their childcare. As a result, it was found that in addition to expanding the nursery teachers’ multifaceted understanding of children, to deep a continuous understanding of children’s everyday life by grasping the children’ s life. Furthermore, as nursery teachers with childrearing experience could better imagine the feelings and everyday life of guardians (parents). Nursery teachers were continuing to work while struggling with the difficulty of balancing the dual roles.
kn-abstract=本研究では，従来あまり検討課題として取り上げられることのなかった子育てを経験している保育士の親としての役割と保育士としての二重役割が，子育て及び保育全体を含めた保護者支援の専門的力量にもたらす相互の関連について検討した。<br>
その結果，保育士の子育て経験は子どもに対する多面的な理解の拡充に加え，園でしか見ることのなかった子どもの姿を家庭での姿も含めて捉えることによって，子どもの日常の連続的な把握を可能にし，子ども理解が深化することが分かった。また，保護者（親）としての当事者性をもった保育士ならではの保護者理解により，保護者の心情や日常への想像力が高まることによって，共感的な理解が深まると共に，保護者に受け入れられる支援を見出す可能性が示された。他方，両立の困難さに葛藤を抱えながら職務を継続している保育士の厳しい現況が改めて確認された。
en-copyright=
kn-copyright=

en-aut-name=KatayamaMika
en-aut-sei=Katayama
en-aut-mei=Mika
kn-aut-name=片山美香
kn-aut-sei=片山
kn-aut-mei=美香
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Faculty of Education, Okayama University
kn-affil=岡山大学学術研究院教育学域
en-keyword=保育士
kn-keyword=保育士
en-keyword=子育て経験
kn-keyword=子育て経験
en-keyword=二重役割
kn-keyword=二重役割
en-keyword=子ども理解
kn-keyword=子ども理解
en-keyword=保護者支援
kn-keyword=保護者支援
END

start-ver=1.4
cd-journal=joma
no-vol=23
cd-vols=
no-issue=1
article-no=
start-page=90
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230213
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Autophagy as a potential mechanism underlying the biological effect of 1,25-Dihydroxyvitamin D3 on periodontitis: a narrative review
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The major active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D3), is known for its wide bioactivity in periodontal tissues. Although the exact mechanisms underlying its protective action against periodontitis remain unclear, recent studies have shown that 1,25D3 regulates autophagy. Autophagy is vital for intracellular pathogen invasion control, inflammation regulation, and bone metabolic balance in periodontal tissue homeostasis, and its regulation could be an interesting pathway for future periodontal studies. Since vitamin D deficiency is a worldwide health problem, its role as a potential regulator of autophagy provides new insights into periodontal diseases. Based on this premise, this narrative literature review aimed to investigate the possible connection between 1,25D3 and autophagy in periodontitis. A comprehensive literature search was conducted on PubMed using the following keywords (e.g., vitamin D, autophagy, periodontitis, pathogens, epithelial cells, immunity, inflammation, and bone loss). In this review, the latest studies on the protective action of 1,25D3 against periodontitis and the regulation of autophagy by 1,25D3 are summarized, and the potential role of 1,25D3-activated autophagy in the pathogenesis of periodontitis is analyzed. 1,25D3 can exert a protective effect against periodontitis through different signaling pathways in the pathogenesis of periodontitis, and at least part of this regulatory effect is achieved through the activation of the autophagic response. This review will help clarify the relationship between 1,25D3 and autophagy in the homeostasis of periodontal tissues and provide perspectives for researchers to optimize prevention and treatment strategies in the future.
en-copyright=
kn-copyright=

en-aut-name=ChenXiaoting
en-aut-sei=Chen
en-aut-mei=Xiaoting
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AriasZulema
en-aut-sei=Arias
en-aut-mei=Zulema
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OmoriKazuhiro
en-aut-sei=Omori
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamamotoTadashi
en-aut-sei=Yamamoto
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=Shinoda-ItoYuki
en-aut-sei=Shinoda-Ito
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TakashibaShogo
en-aut-sei=Takashiba
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Pathophysiology‑Periodontal Science, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University 
kn-affil=

affil-num=2
en-affil=Department of Pathophysiology‑Periodontal Science, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University 
kn-affil=

affil-num=3
en-affil=Department of Periodontics and Endodontics, Okayama University  Hospital
kn-affil=

affil-num=4
en-affil=Department of Pathophysiology‑Periodontal Science, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Pathophysiology‑Periodontal Science, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Pathophysiology‑Periodontal Science, Graduate School  of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Vitamin D
kn-keyword=Vitamin D
en-keyword=Autophagy
kn-keyword=Autophagy
en-keyword=Periodontitis
kn-keyword=Periodontitis
en-keyword=Epithelial barrier
kn-keyword=Epithelial barrier
en-keyword=Immunity
kn-keyword=Immunity
en-keyword=Inflammation
kn-keyword=Inflammation
en-keyword=Alveolar bone loss
kn-keyword=Alveolar bone loss
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=1
article-no=
start-page=21
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202302
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Analysis of Phase Angle and Balance and Gait Functions in Pre-Frail Individuals: A Cross-Sectional Observational Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We measured the muscle mass and phase angle of each body part to evaluate the relationship between balance and gait functions in individuals with a pre-frailty status. This cross-sectional observational study determined the skeletal muscle mass-to-body weight ratio and phase angles of 21 control (robust) and 29 pre-frail subjects. Their Brief-Balance Evaluation Systems Test, Timed Up-and-Go (TUG) test, Life-Space Assessment, and Modified Fall Efficacy Scale scores plus the relationship between muscle mass, phase angle, and motor function were evaluated. In the pre-frailty group (three males, 26 females, aged 75.58±7.60 years), significant correlations were noted between the Brief-Balance Evaluation Systems Test score and lower-limb (r=0.614) and wholebody (r=0.557) phase angles, and between the TUG test score and lower-limb muscle mass-to-body weight ratio (r=−0.616), lower-limb phase angle (r=−0.616), and whole-body phase angle (r=−0.527). Evaluating the phase angle of the lower extremities of pre-frail patients and intervening accordingly may help clinicians maintain and improve these patients’ balance and gait functions.
en-copyright=
kn-copyright=

en-aut-name=HommaDaisuke
en-aut-sei=Homma
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MinatoIzumi
en-aut-sei=Minato
en-aut-mei=Izumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ImaiNorio
en-aut-sei=Imai
en-aut-mei=Norio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MiyasakaDai
en-aut-sei=Miyasaka
en-aut-mei=Dai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SakaiYoshinori
en-aut-sei=Sakai
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HorigomeYoji
en-aut-sei=Horigome
en-aut-mei=Yoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SuzukiHayato
en-aut-sei=Suzuki
en-aut-mei=Hayato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=DohmaeYoichiro
en-aut-sei=Dohmae
en-aut-mei=Yoichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=EndoNaoto
en-aut-sei=Endo
en-aut-mei=Naoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Orthopaedic Surgery, Niigata University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=2
en-affil=Division of Orthopaedic Surgery, Niigata Rinko Hospital
kn-affil=

affil-num=3
en-affil=Comprehensive Musculoskeletal Medicine, Niigata University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=4
en-affil=Division of Orthopaedic Surgery, Niigata Bandai Hospital
kn-affil=

affil-num=5
en-affil=Division of Orthopaedic Surgery, Niigata City General Hospital
kn-affil=

affil-num=6
en-affil=Comprehensive Musculoskeletal Medicine, Niigata University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=7
en-affil=Orthopaedic Surgery, Niigata University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=8
en-affil=Division of Orthopaedic Surgery, Niigata Bandai Hospital
kn-affil=

affil-num=9
en-affil=Division of Orthopaedic Surgery, Niigata Prefectural Tsubame Rosai Hospital
kn-affil=
en-keyword=bioelectrical impedance analysis
kn-keyword=bioelectrical impedance analysis
en-keyword=motor function
kn-keyword=motor function
en-keyword=muscle quality
kn-keyword=muscle quality
en-keyword=muscle volume
kn-keyword=muscle volume
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=134580
end-page=134591
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20221226
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Neg/pos-Normalized Accuracy Measures for Software Defect Prediction
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In evaluating the performance of software defect prediction models, accuracy measures such as precision and recall are commonly used. However, most of these measures are affected by neg/pos ratio of the data set being predicted, where neg is the number of negative cases (defect-free modules) and pos is the number of positive cases (defective modules). Thus, it is not fair to compare such values across different data sets with different neg/pos ratios and it may even lead to misleading or contradicting conclusions. The objective of this study is to address the class imbalance issue in assessing performance of defect prediction models. The proposed method relies on computation of expected values of accuracy measures based solely on the value of the neg and pos values of the data set. Based on the expected values, we derive the neg/pos-normalized accuracy measures, which are defined as their divergence from the expected value divided by the standard deviation of all possible prediction outcomes. The proposed measures enable us to provide a ranking of predictions across different data sets, which can distinguish between successful predictions and unsuccessful predictions. Our results derived from a case study of defect prediction based on 19 defect data sets indicate that ranking of predictions is significantly different than the ranking of conventional accuracy measures such as precision and recall as well as composite measures F1-value, AUC of ROC, MCC, G-mean and Balance. In addition, we conclude that MCC attains a better defect prediction accuracy than F1-value, AUC of ROC, G-mean and Balance.
en-copyright=
kn-copyright=

en-aut-name=GanMaohua
en-aut-sei=Gan
en-aut-mei=Maohua
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YucelZeynep
en-aut-sei=Yucel
en-aut-mei=Zeynep
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MondenAkito
en-aut-sei=Monden
en-aut-mei=Akito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Software defect
kn-keyword=Software defect
en-keyword=defect prediction model
kn-keyword=defect prediction model
en-keyword=accuracy measure
kn-keyword=accuracy measure
en-keyword=classification technology
kn-keyword=classification technology
en-keyword=empirical software engineering
kn-keyword=empirical software engineering
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=5
article-no=
start-page=503
end-page=510
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Viral Sequences Are Repurposed for Controlling Antiviral Responses as Non-Retroviral Endogenous Viral Elements
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches.
en-copyright=
kn-copyright=

en-aut-name=OgawaHirohito
en-aut-sei=Ogawa
en-aut-mei=Hirohito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HondaTomoyuki
en-aut-sei=Honda
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Virology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Virology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=EVE
kn-keyword=EVE
en-keyword=nrEVE
kn-keyword=nrEVE
en-keyword=bornavirus
kn-keyword=bornavirus
en-keyword=filovirus
kn-keyword=filovirus
en-keyword=antiviral
kn-keyword=antiviral
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=4
article-no=
start-page=359
end-page=371
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202208
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Therapeutic Approaches Targeting miRNA in Systemic Lupus Erythematosus
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE.
en-copyright=
kn-copyright=

en-aut-name=Hiramatsu-AsanoSumie
en-aut-sei=Hiramatsu-Asano
en-aut-mei=Sumie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=systemic lupus erythematosus
kn-keyword=systemic lupus erythematosus
en-keyword=miRNA
kn-keyword=miRNA
en-keyword=miRNA targeting therapy
kn-keyword=miRNA targeting therapy
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=
article-no=
start-page=891925
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220802
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Responses of regulatory and effector T-cells to low-dose interleukin-2 differ depending on the immune environment after allogeneic stem cell transplantation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=CD4(+)Foxp3(+) regulatory T cells (Tregs) play a central role in the maintenance of immune tolerance after allogeneic hematopoietic stem cell transplantation (HSCT). Tregs promptly respond to low concentrations of IL-2 through the constitutive expression of high-affinity IL-2 receptors. It has been reported that low-dose IL-2 therapy increased circulating Tregs and improved clinical symptoms of chronic GVHD. Clinical studies of IL-2 therapy so far have mainly targeted patients in the chronic phase of transplantation when acute immune responses has subsided. However, the biological and clinical effects of exogenous IL-2 in an acute immune environment have not been well investigated. In the current study, we investigated the impact of exogenous IL-2 therapy on the post-transplant homeostasis of T cell subsets which influence the balance between GVHD and GVL in the acute phase, by setting the various immune environments early after HSCT in murine model. We initially found that 5,000 IU of IL-2 was enough to induce the active proliferation of Treg without influencing other conventional T cells (Tcons) when administered to normal mice. However, activated Tcons showed the response to the same dose of IL-2 in recipients after allogeneic HSCT. In a mild inflammatory environment within a threshold, exogenous IL-2 could effectively modulate Treg homeostasis with just limited influence to activated T cells, which resulted in an efficient GVHD suppression. In contrast, in a severely inflammatory environment, exogenous IL-2 enhanced activated T cells rather than Tregs, which resulted in the exacerbation of GVHD. Of interest, in an immune-tolerant state after transplant, exogenous IL-2 triggered effector T-cells to exert an anti-tumor effect with maintaining GVHD suppression. These data suggested that the responses of Tregs and effector T cells to exogenous IL-2 differ depending on the immune environment in the host, and the mutual balance of the response to IL-2 between T-cell subsets modulates GVHD and GVL after HSCT. Our findings may provide useful information in the optimization of IL-2 therapy, which may be personalized for each patient having different immune status.
en-copyright=
kn-copyright=

en-aut-name=MeguriYusuke
en-aut-sei=Meguri
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AsanoTakeru
en-aut-sei=Asano
en-aut-mei=Takeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YoshiokaTakanori
en-aut-sei=Yoshioka
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IwamotoMiki
en-aut-sei=Iwamoto
en-aut-mei=Miki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IkegawaShuntaro
en-aut-sei=Ikegawa
en-aut-mei=Shuntaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SugiuraHiroyuki
en-aut-sei=Sugiura
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KishiYuriko
en-aut-sei=Kishi
en-aut-mei=Yuriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakamuraMakoto
en-aut-sei=Nakamura
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SandoYasuhisa
en-aut-sei=Sando
en-aut-mei=Yasuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KondoTakumi
en-aut-sei=Kondo
en-aut-mei=Takumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SumiiYuichi
en-aut-sei=Sumii
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=MatsuokaKen-Ichi
en-aut-sei=Matsuoka
en-aut-mei=Ken-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=regulatory T cell
kn-keyword=regulatory T cell
en-keyword=low-dose interleukin-2 therapy
kn-keyword=low-dose interleukin-2 therapy
en-keyword=graft-versus-host disease
kn-keyword=graft-versus-host disease
en-keyword=graft-versus-leukemia effect
kn-keyword=graft-versus-leukemia effect
en-keyword=transplantation tolerance
kn-keyword=transplantation tolerance
END

start-ver=1.4
cd-journal=joma
no-vol=23
cd-vols=
no-issue=14
article-no=
start-page=7856
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220716
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Muscle Fiber Composition Changes after Selective Nerve Innervation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Facial nerve paralysis interferes with mimetic muscle function. To reconstruct natural facial movement, free muscle flaps are transplanted as new muscles. However, it is difficult to maintain resting tonus. A dual innervation technique in which other nerves such as the hypoglossal nerve or contralateral facial nerve are added is often applied. Using 10-week-old rats (n = 10), the masseteric and hypoglossal nerves were cut, and the distal stump of the masseteric nerve and the proximal stump of the hypoglossal nerve were then sutured (suture group). In the other group, the masseteric nerve was cut and cauterized (cut group). Immunohistochemistry and microarray were performed on the extracted masseter muscle. The immunohistochemistry results suggested that the muscles in the suture group obtained oxidative characteristics. The microarray showed the genes involved in mitochondrial function, including Perm1. In summary, our data support the validity of the dualinnervation technique for facial paralysis treatment.
en-copyright=
kn-copyright=

en-aut-name=WatanabeShiho
en-aut-sei=Watanabe
en-aut-mei=Shiho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OchiaiHiroko
en-aut-sei=Ochiai
en-aut-mei=Hiroko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SakumaHisashi
en-aut-sei=Sakuma
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MoriTaisuke
en-aut-sei=Mori
en-aut-mei=Taisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YazawaMasaki
en-aut-sei=Yazawa
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OkaAiko
en-aut-sei=Oka
en-aut-mei=Aiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KishiKazuo
en-aut-sei=Kishi
en-aut-mei=Kazuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital,
kn-affil=

affil-num=2
en-affil=Laboratory of Regenerative Medicine, Department of Plastic and Reconstructive Surgery, Division of Hearing and Balance Disorder, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center
kn-affil=

affil-num=3
en-affil=Department of Plastic and Reconstructive Surgery, Tokyo Dental College Ichikawa General Hospital
kn-affil=

affil-num=4
en-affil=Department of Pathology, National Cancer Center Research Institute
kn-affil=

affil-num=5
en-affil=Department of Plastic and Reconstructive Surgery, Keio University School of Medicine
kn-affil=

affil-num=6
en-affil=Laboratory of Regenerative Medicine, Department of Plastic and Reconstructive Surgery, Division of Hearing and Balance Disorder, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center
kn-affil=

affil-num=7
en-affil=Department of Plastic and Reconstructive Surgery, Keio University School of Medicine
kn-affil=
en-keyword=muscle fiber type
kn-keyword=muscle fiber type
en-keyword=facial paralysis
kn-keyword=facial paralysis
en-keyword=dualinnervation
kn-keyword=dualinnervation
en-keyword=masseter muscle
kn-keyword=masseter muscle
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=3
article-no=
start-page=273
end-page=280
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Possibility of Predicting Pelvic Inclination Following Total Hip Arthroplasty Based on the Preoperative State: Sacral Slope and Pelvic Incidence Minus Lumbar Lordosis as Predictive Factors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Following total hip arthroplasty (THA), some patients exhibit anterior or posterior pelvic tilt (PT). This case– control study investigated whether changes to PT following THA can be preoperatively predicted. Methods: 135 patients with hip osteoarthritis who underwent THA were assessed. The parameters measured preoperatively and one year postoperatively were lumbar lordosis (LL) based on plain X-ray and pelvic incidence (PI), PT, and sacral slope (SS), all of which were measured as pelvic morphological angles. Patients were classified into groups (A–E) based on the degree of post-THA PT, and their preoperative conditions were compared. PI minus LL was used to evaluate spinal alignment and pelvic balance. Results: Overall, 33%, 30%, 21%, 13%, and 3% of the hips of patients in Groups A, B, C, D, and E were postoperatively assessed. In Groups A–E, the SS values were 34.6°±8.9°, 37.6°±8.4°, 37.9°±8.9°, 42.6°±9.5°, and 60.0°±11.1°, whereas the PI minus LL values were 2.9°±15.0°, 1.2°±13.6°, 3.6°±17.7°, 12.7°±13.1°, and −1.3°±11.7°, respectively. Conclusions: Following THA, 70% of patients experienced posterior PT. Pre-THA SS ≥45° or PI minus LL ≥15° signified marked postoperative posterior tilt and could predict postoperative PT following THA. These findings are useful for implant placement, as they can predict pelvic inclination.
en-copyright=
kn-copyright=

en-aut-name=FuruichiShuro
en-aut-sei=Furuichi
en-aut-mei=Shuro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MitaniShigeru
en-aut-sei=Mitani
en-aut-mei=Shigeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=EndoHirosuke
en-aut-sei=Endo
en-aut-mei=Hirosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NambaYoshifumi
en-aut-sei=Namba
en-aut-mei=Yoshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawamotoToyohiro
en-aut-sei=Kawamoto
en-aut-mei=Toyohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School
kn-affil=

affil-num=2
en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School
kn-affil=

affil-num=3
en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School
kn-affil=

affil-num=4
en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School
kn-affil=

affil-num=5
en-affil=Department of Bone and Joint Surgery, Kawasaki Medical School
kn-affil=
en-keyword=hip
kn-keyword=hip
en-keyword=total hip arthroplasty
kn-keyword=total hip arthroplasty
en-keyword=arthroplasty
kn-keyword=arthroplasty
en-keyword=radiography
kn-keyword=radiography
en-keyword=lordosis
kn-keyword=lordosis
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=3
article-no=
start-page=235
end-page=245
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Roles of Transmembrane Protein 97 (TMEM97) in Adipose Tissue and Skeletal Muscle
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The combination of sarcopenia and obesity (sarcopenic obesity) is associated with the development of metabolic syndrome and cardiovascular events. The molecular pathways that develop sarcopenic obesity have studied intensively. Transmembrane protein 97 (TMEM97) is 176 amino acids conserved integral membrane protein with four transmembrane domains that is expressed in several types of cancer. Its physiological significance in adipose tissue and skeletal muscle has been unclear. We studied TMEM97-transgenic mice and mice lacking TMEM97, and our findings indicate that TMEM97 expression is regulated in adipose tissue and skeletal muscle from obesity. TMEM97 represses adipogenesis and promotes myogenesis in vitro. Fat-specific TMEM97 transgenic mice showed systemic insulin resistance. Mice overexpressing TMEM97 in skeletal muscle exhibited systemic insulin resistance. Mice lacking TMEM97 were protected against diet-induced obesity and insulin resistance. These phenotypes are associated with the effects of TMEM97 on inflammation genes in adipose tissue and skeletal muscle. Our findings indicates that there is a link between TMEM97 and chronic inflammation in obesity.
en-copyright=
kn-copyright=

en-aut-name=TentaMasafumi
en-aut-sei=Tenta
en-aut-mei=Masafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=EguchiJun
en-aut-sei=Eguchi
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=adipose tissue
kn-keyword=adipose tissue
en-keyword=skeletal muscle
kn-keyword=skeletal muscle
en-keyword=obesity
kn-keyword=obesity
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=DHI質問用紙でのバランスの主観的評価からは転倒リスクを予想できない：耳鼻科外来を受診した高齢者でのデータ
kn-title=Subjective Evaluation of Balance by the Dizziness Handicap Inventory Does Not Predict Fall Risk in Older Adults Visiting Otolaryngology Clinics
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FujisawaIku
en-aut-sei=Fujisawa
en-aut-mei=Iku
kn-aut-name=藤澤郁
kn-aut-sei=藤澤
kn-aut-mei=郁
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=123
cd-vols=
no-issue=5
article-no=
start-page=3698
end-page=3728
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20185
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Production of High‐Sr Andesite and Dacite Magmas by Melting of Subducting Oceanic Lithosphere at Propagating Slab Tears
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We present K-Ar ages, major and trace element concentrations, and Sr-Nd-Pb isotope data for late Cenozoic volcanic rocks from the Chugoku district, southwest Japan arc. Andesite and dacite lavas in this region are enriched in Sr (mostly >800 μg g−1) and show geochemical characteristics of volcanic rocks commonly referred to as “adakite.” K-Ar dating of these lavas revealed that the eruption of high-Sr andesitic to dacitic magmas occurred during the last 2 Myr, following or concurrent with the eruption of basalt in adjacent regions. Trace-element characteristics of high-Sr andesites and dacites are consistent with the formation of their parent magmas by partial melting of the basaltic layer of the subducting Shikoku Basin Plate. Mass balance modeling of trace element concentrations and isotopic compositions suggests that the parental magmas of high-Sr andesites and dacites are best explained by mixing of partial melts from oceanic crust (F = 5–15%) and sediment (F = 30%) at 80:20 to 55:45 ratios. Spatial coincidence of the occurrences of high-Sr andesites and dacites and seismic gaps of the subducting slab demonstrates the causal link between slab melting and mantle upwelling at slab tears. We speculate that these tears could have been formed by subduction of ridges on the plate. A warm mantle upwelled through tears, preventing the solidification of the siliceous slab melts in the mantle and facilitating the transportation of these melts to the surface.
en-copyright=
kn-copyright=

en-aut-name=Pineda‐VelascoI.
en-aut-sei=Pineda‐Velasco
en-aut-mei=I.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KitagawaH.
en-aut-sei=Kitagawa
en-aut-mei=H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NguyenT. ‐T.
en-aut-sei=Nguyen
en-aut-mei=T. ‐T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KobayashiK.
en-aut-sei=Kobayashi
en-aut-mei=K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakamuraE.
en-aut-sei=Nakamura
en-aut-mei=E.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University at Misasa
kn-affil=

affil-num=2
en-affil=Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University at Misasa
kn-affil=

affil-num=3
en-affil=Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University at Misasa
kn-affil=

affil-num=4
en-affil=Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University at Misasa
kn-affil=

affil-num=5
en-affil=Pheasant Memorial Laboratory, Institute for Planetary Materials, Okayama University at Misasa
kn-affil=
en-keyword=adakite
kn-keyword=adakite
en-keyword=subduction zone
kn-keyword=subduction zone
en-keyword=slab melting
kn-keyword=slab melting
en-keyword=slab tear
kn-keyword=slab tear
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=2
article-no=
start-page=154
end-page=159
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=2022
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The typical indication of radon therapy is rheumatoid arthritis. Although there are several reports that radon therapy has regulation effects on Th17 cells, there has been no study reporting that radon inhalation affects the immune balance among Th1, Th2, and Th17. The purpose of this study is to examine the cytokine changes after radon inhalation. BALB/c mice inhaled radon at 2,000 Bq/m3 for 2 or 4 weeks. SKG/Jcl mice inhaled radon at 2,000 Bq/m3 for 4 weeks after zymosan administration. The results showed that radon inhalation for 4 weeks activated the immune response of Th1, Th2, and Th17. Moreover, the balance among them was not lost by radon inhalation. Radon inhalation for 4 weeks decreased superoxide dismutase activity and increased catalase activity in spleen. These findings suggest that an imbalance of oxidative stress may contribute to activate the immune response. Although zymosan administration activated Th17 immune response and decreased Th1 and Th2 immune response in SKG/Jcl mice, most cytokines related to Th1, Th2, and Th17 approached the normal level by radon inhalation. These findings suggested that radon inhalation has a different action between SKG/Jcl mice and normal BABL/c mice. This may indicate that radon inhalation has an immunomodulation function.
en-copyright=
kn-copyright=

en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NaoeShota
en-aut-sei=Naoe
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MurakamiKaito
en-aut-sei=Murakami
en-aut-mei=Kaito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YukimineRyohei
en-aut-sei=Yukimine
en-aut-mei=Ryohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujimotoYuki
en-aut-sei=Fujimoto
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KanzakiNorie
en-aut-sei=Kanzaki
en-aut-mei=Norie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=

affil-num=7
en-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
kn-affil=

affil-num=8
en-affil=Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=radon
kn-keyword=radon
en-keyword=cytokine
kn-keyword=cytokine
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=rheumatoid arthritis
kn-keyword=rheumatoid arthritis
en-keyword=immunomodulation function
kn-keyword=immunomodulation function
END

start-ver=1.4
cd-journal=joma
no-vol=28
cd-vols=
no-issue=1
article-no=
start-page=48
end-page=53
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20181
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Covariate balance for no confounding in the sufficient-cause model
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose: To show conditions of covariate balance for no confounding in the sufficient-cause model and discuss its relationship with exchangeability conditions.<br>
Methods: We consider the link between the sufficient-cause model and the counterfactual model, emphasizing that the target population plays a key role when discussing these conditions. Furthermore, we incorporate sufficient causes within the directed acyclic graph framework. We propose to use each of the background factors in sufficient causes as representing a set of covariates of interest and discuss the presence of covariate balance by comparing joint distributions of the relevant background factors between the exposed and the unexposed groups.<br>
Results: We show conditions for partial covariate balance, covariate balance, and full covariate
balance, each of which is stronger than partial exchangeability, exchangeability, and full exchangeability, respectively. This is consistent with the fact that the sufficient-cause model is a “finer” model than the counterfactual model.<br>
Conclusions: Covariate balance is a sufficient, but not a necessary, condition for no confounding irrespective of the target population. Although our conceptualization of covariate imbalance is closely related to the recently proposed counterfactual-based definition of a confounder, the concepts of covariate balance and confounder should be clearly distinguished.
en-copyright=
kn-copyright=

en-aut-name=SuzukiEtsuji
en-aut-sei=Suzuki
en-aut-mei=Etsuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TsudaToshihide
en-aut-sei=Tsuda
en-aut-mei=Toshihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamamotoEiji
en-aut-sei=Yamamoto
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Human Ecology, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Information Science, Faculty of Informatics, Okayama University of Science
kn-affil=
en-keyword=bias
kn-keyword=bias
en-keyword=causality
kn-keyword=causality
en-keyword=confounding factors
kn-keyword=confounding factors
en-keyword=epidemiologic methods
kn-keyword=epidemiologic methods
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=5
article-no=
start-page=601
end-page=609
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Effect of Peer Instruction Lectures on Learning Attitudes in Epidemiology Education
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Research suggests that the fundamental concepts of epidemiology cannot be sufficiently learned in traditional lectures, and interactive learning is necessary. However, few studies have investigated interactive epidemiology education in general, or peer instruction (PI) in particular. This study investigated the effect of PI. Study par-ticipants were fourth-year medical students. The attitude of participants in regard to PI learning was examined in a non-PI and a PI group. The Survey of Attitudes Toward Statistics (SATS) (containing six sub-categories) was conducted as a learning-attitudes index. The pre- and post-lecture scores were compared between the non-PI and PI groups using double robust (DR) estimation. The non-PI and PI groups consisted of 20 and 121 student participants, respectively. In DR estimation, affect exhibited the lowest SATS score changes, at −0.51 (95% confidence interval −0.78 to −0.24; p-value < 0.001), whereas effort exhibited the highest score changes of 0.01 (95% confidence interval −0.30 to 0.32; p-value = 0.952). The epidemiology lecture with PI did not increase the SATS scores. This might be due to issues related to the experimental design. Further research investigating the effects of interactive epidemiology education, it will be necessary to develop tools for assessing the learning of epidemiological concepts and to improve the research design.
en-copyright=
kn-copyright=

en-aut-name=MitsuhashiToshiharu
en-aut-sei=Mitsuhashi
en-aut-mei=Toshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=
en-keyword=medical students
kn-keyword=medical students
en-keyword=peer instruction
kn-keyword=peer instruction
en-keyword=epidemiological education
kn-keyword=epidemiological education
en-keyword=learning attitude
kn-keyword=learning attitude
en-keyword=double robust esti-mation
kn-keyword=double robust esti-mation
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=1
article-no=
start-page=13125
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210623
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Reduced dose of PTCy followed by adjuvant alpha-galactosylceramide enhances GVL effect without sacrificing GVHD suppression
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Posttransplantation cyclophosphamide (PTCy) has become a popular option for haploidentical hematopoietic stem cell transplantation (HSCT). However, personalized methods to adjust immune intensity after PTCy for each patient's condition have not been well studied. Here, we investigated the effects of reducing the dose of PTCy followed by alpha -galactosylceramide (alpha -GC), a ligand of iNKT cells, on the reciprocal balance between graft-versus-host disease (GVHD) and the graft-versus-leukemia (GVL) effect. In a murine haploidentical HSCT model, insufficient GVHD prevention after reduced-dose PTCy was efficiently compensated for by multiple administrations of alpha -GC. The ligand treatment maintained the enhanced GVL effect after reduced-dose PTCy. Phenotypic analyses revealed that donor-derived B cells presented the ligand and induced preferential skewing to the NKT2 phenotype rather than the NKT1 phenotype, which was followed by the early recovery of all T cell subsets, especially CD4(+)Foxp3(+) regulatory T cells. These studies indicate that alpha -GC administration soon after reduced-dose PTCy restores GVHD-preventing activity and maintains the GVL effect, which is enhanced by reducing the dose of PTCy. Our results provide important information for the development of a novel strategy to optimize PTCy-based transplantation, particularly in patients with a potential relapse risk.
en-copyright=
kn-copyright=

en-aut-name=NakamuraMakoto
en-aut-sei=Nakamura
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MeguriYusuke
en-aut-sei=Meguri
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IkegawaShuntaro
en-aut-sei=Ikegawa
en-aut-mei=Shuntaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KondoTakumi
en-aut-sei=Kondo
en-aut-mei=Takumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SumiiYuichi
en-aut-sei=Sumii
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FukumiTakuya
en-aut-sei=Fukumi
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IwamotoMiki
en-aut-sei=Iwamoto
en-aut-mei=Miki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SandoYasuhisa
en-aut-sei=Sando
en-aut-mei=Yasuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SugiuraHiroyuki
en-aut-sei=Sugiura
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=AsadaNoboru
en-aut-sei=Asada
en-aut-mei=Noboru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=EnnishiDaisuke
en-aut-sei=Ennishi
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=TomidaShuta
en-aut-sei=Tomida
en-aut-mei=Shuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=Fukuda-KawaguchiEmi
en-aut-sei=Fukuda-Kawaguchi
en-aut-mei=Emi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=IshiiYasuyuki
en-aut-sei=Ishii
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=MatsuokaKen-Ichi
en-aut-sei=Matsuoka
en-aut-mei=Ken-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

affil-num=1
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Hematology and Oncology, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Hematology and Oncology, Okayama University Hospital
kn-affil=

affil-num=12
en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital
kn-affil=

affil-num=13
en-affil=REGiMMUNE Corporation
kn-affil=

affil-num=14
en-affil=REGiMMUNE Corporation
kn-affil=

affil-num=15
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=16
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=1
article-no=
start-page=1100
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210217
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Structure of photosystem I-LHCI-LHCII from the green alga Chlamydomonas reinhardtii in State 2
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Photosystem I (PSI) and II (PSII) balance their light energy distribution absorbed by their light-harvesting complexes (LHCs) through state transition to maintain the maximum photosynthetic performance and to avoid photodamage. In state 2, a part of LHCII moves to PSI, forming a PSI-LHCI-LHCII supercomplex. The green alga Chlamydomonas reinhardtii exhibits state transition to a far larger extent than higher plants. Here we report the cryo-electron microscopy structure of a PSI-LHCI-LHCII supercomplex in state 2 from C. reinhardtii at 3.42 Å resolution. The result reveals that the PSI-LHCI-LHCII of C. reinhardtii binds two LHCII trimers in addition to ten LHCI subunits. The PSI core subunits PsaO and PsaH, which were missed or not well-resolved in previous Cr-PSI-LHCI structures, are observed. The present results reveal the organization and assembly of PSI core subunits, LHCI and LHCII, pigment arrangement, and possible pathways of energy transfer from peripheral antennae to the PSI core.
en-copyright=
kn-copyright=

en-aut-name=HuangZihui
en-aut-sei=Huang
en-aut-mei=Zihui
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShenLiangliang
en-aut-sei=Shen
en-aut-mei=Liangliang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WangWenda
en-aut-sei=Wang
en-aut-mei=Wenda
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MaoZhiyuan
en-aut-sei=Mao
en-aut-mei=Zhiyuan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YiXiaohan
en-aut-sei=Yi
en-aut-mei=Xiaohan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KuangTingyun
en-aut-sei=Kuang
en-aut-mei=Tingyun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ShenJian-Ren
en-aut-sei=Shen
en-aut-mei=Jian-Ren
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ZhangXing
en-aut-sei=Zhang
en-aut-mei=Xing
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HanGuangye
en-aut-sei=Han
en-aut-mei=Guangye
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Biophysics, and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
kn-affil=

affil-num=2
en-affil=Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences
kn-affil=

affil-num=3
en-affil=Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences
kn-affil=

affil-num=4
en-affil=Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences
kn-affil=

affil-num=5
en-affil=Department of Biophysics, and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
kn-affil=

affil-num=6
en-affil=Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences
kn-affil=

affil-num=7
en-affil=Institute for Interdisciplinary Science, and Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Biophysics, and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
kn-affil=

affil-num=9
en-affil=Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=571369
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210127
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Stimulus Intervals Modulate the Balance of Brain Activity in the Human Primary Somatosensory Cortex: An ERP Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Neuronal excitation and inhibition occur in the brain at the same time, and brain activation reflects changes in the sum of excitation and inhibition. This principle has been well-established in lower-level sensory systems, including vision and touch, based on animal studies. However, it is unclear how the somatosensory system processes the balance between excitation and inhibition. In the present ERP study, we modified the traditional spatial attention paradigm by adding double stimuli presentations at short intervals (i.e., 10, 30, and 100 ms). Seventeen subjects participated in the experiment. Five types of stimulation were used in the experiment: a single stimulus (one raised pin for 40 ms), standard stimulus (eight pins for 40 ms), and double stimuli presented at intervals of 10, 30, and 100 ms. The subjects were asked to attend to a particular finger and detect whether the standard stimulus was presented to that finger. The results showed a clear attention-related ERP component in the single stimulus condition, but the suppression components associated with the three interval conditions seemed to be dominant in somatosensory areas. In particular, we found the strongest suppression effect in the ISI-30 condition (interval of 30 ms) and that the suppression and enhancement effects seemed to be counterbalanced in both the ISI-10 and ISI-100 conditions (intervals of 10 and 100 ms, respectively). This type of processing may allow humans to easily discriminate between multiple stimuli on the same body part.
en-copyright=
kn-copyright=

en-aut-name=LiuYang
en-aut-sei=Liu
en-aut-mei=Yang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DongBo
en-aut-sei=Dong
en-aut-mei=Bo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YangJiajia
en-aut-sei=Yang
en-aut-mei=Jiajia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=EjimaYoshimichi
en-aut-sei=Ejima
en-aut-mei=Yoshimichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WuJinglong
en-aut-sei=Wu
en-aut-mei=Jinglong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=WuQiong
en-aut-sei=Wu
en-aut-mei=Qiong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ZhangMing
en-aut-sei=Zhang
en-aut-mei=Ming
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Psychology, Suzhou University of Science and Technology
kn-affil=

affil-num=2
en-affil=Department of Psychology, Suzhou University of Science and Technology
kn-affil=

affil-num=3
en-affil=Cognitive Neuroscience Laboratory, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Cognitive Neuroscience Laboratory, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Cognitive Neuroscience Laboratory, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=Cognitive Neuroscience Laboratory, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=7
en-affil=Cognitive Neuroscience Laboratory, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=traditional spatial attention paradigm
kn-keyword=traditional spatial attention paradigm
en-keyword=ERP
kn-keyword=ERP
en-keyword=interstimulus interval
kn-keyword=interstimulus interval
en-keyword=enhancement and suppression
kn-keyword=enhancement and suppression
en-keyword=primary somatosensory cortex
kn-keyword=primary somatosensory cortex
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=7
article-no=
start-page=916
end-page=921
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200708
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Albedo of Ryugu: Evidence for a High Organic Abundance, as Inferred from the Hayabusa2 Touchdown Maneuver
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The Hayabusa2 mission successfully collected samples from the asteroid Ryugu last year and will return these to Earth in December 2020. It is anticipated that the samples will enable the analysis of terrestrially uncontaminated organic matter and minerals. Such analyses are in turn expected to elucidate the evolution of organic matter through Solar System history, including the origination and processing of biogenically important molecules, which could have been utilized by the first organisms on Earth. In anticipation, studies have made predictions concerning the properties of Ryugu, including its composition. The spectral characteristics of Ryugu, such as albedo, have been employed to relate the asteroid to members of the carbonaceous chondrite group that have been identified on Earth. However, the recent Hayabusa2 touchdown highlights a disparity between the color of surfaces of displaced platy fragments, indicating a brightening trend for the surface exposed to space compared to that facing into the body. Here we present a mass balance calculation with reference to data from the literature, which indicates that Ryugu may contain a significantly higher abundance of organic matter (likely >50%) than the currently most accepted meteorite analogues. A high organic content may result in high levels of extractable organic matter for the second touchdown site, where the spacecraft sampled freshly exposed material. However, high abundances of insoluble aromatic/graphitic rich organic matter may be present in the first touchdown site, which sampled the surface of Ryugu that had been exposed to space. Moreover, we suggest that the potentially high organic abundance and the rubble-pile nature of Ryugu may originate from the capture of rocky debris by a comet nucleus and subsequent water-organic-mineral interactions and sublimation of water ice.
en-copyright=
kn-copyright=

en-aut-name=PotiszilChristian
en-aut-sei=Potiszil
en-aut-mei=Christian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TanakaRyoji
en-aut-sei=Tanaka
en-aut-mei=Ryoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KobayashiKatsura
en-aut-sei=Kobayashi
en-aut-mei=Katsura
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KunihiroTak
en-aut-sei=Kunihiro
en-aut-mei=Tak
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakamuraEizo
en-aut-sei=Nakamura
en-aut-mei=Eizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=2
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=3
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=4
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=5
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=
en-keyword=Hayabusa2
kn-keyword=Hayabusa2
en-keyword=Ryugu
kn-keyword=Ryugu
en-keyword=Sample return
kn-keyword=Sample return
en-keyword=Organic matter
kn-keyword=Organic matter
en-keyword=Albedo. Astrobiology 20, 916–921
kn-keyword=Albedo. Astrobiology 20, 916–921
END

start-ver=1.4
cd-journal=joma
no-vol=27
cd-vols=
no-issue=
article-no=
start-page=4298
end-page=4317
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201207
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Multi‐scale inter‐temporal capital asset pricing model
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study investigates the multi‐scale inter‐temporal capital asset pricing model (ICAPM). We focus upon differences across timescales since they represent heterogeneities of investors in markets. This study employs a wavelet approach to decompose return data into multiple timescales. Furthermore, we impose a same risk‐aversion parameter constraint into all portfolios, which is proposed by Engle and Bali who show that the constraint provides a reasonable equity risk premium at a daily frequency. We observe positive relations between the expected returns on portfolios and the covariance of the market at a daily frequency, while these relations change as timescales increase. We find that a negative risk–return relation, which might be related to a correction process of overreaction at an approximately weekly frequency (2–16 days). The strongest positive relation is observed at an approximately monthly frequency (16–32 days). Monthly portfolio re‐balances are widely used and might impact stock market return patterns. The equity risk premium in the longer frequency ranges from 8.64 to 11.10%. Our results are robust after controlling for macroeconomic variables, market implied volatility and test portfolios. Moreover, we investigate size and value factors and reveal that the risk premia disappear in the longer frequency, which suggests that ICAPM is satisfied.
en-copyright=
kn-copyright=

en-aut-name=SakemotoRyuta
en-aut-sei=Sakemoto
en-aut-mei=Ryuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=
en-keyword=ICAPM
kn-keyword=ICAPM
en-keyword=investment horizon
kn-keyword=investment horizon
en-keyword=risk factor
kn-keyword=risk factor
en-keyword=risk‐aversion
kn-keyword=risk‐aversion
en-keyword=wavelet
kn-keyword=wavelet
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=1
article-no=
start-page=427
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201023
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Release and extraction of retained subfoveal perfluorocarbon liquid facilitated by subretinal BSS, vibration, and gravity: a case report
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background</br>
Perfluorocarbon liquid (PFCL) is an effective surgical adjuvant in performing vitrectomy for severe vitreoretinal pathologies such as proliferative vitreoretinopathy and giant retinal tears. However, subretinal retention of PFCL can occur postoperatively and retained PFCL causes severe visual disorders, particularly when PFCL was retained under the fovea. Although several procedures have been proposed for subfoveal PFCL removal, such as direct aspiration or submacular injection of balanced salt solution (BSS) to dislodge the subfoveal PFCL, the retinal damage associated with these procedures has been a major problem. Here, we report a case of subfoveal retention of PFCL for which we performed a novel surgical technique that attempts to minimize retinal damage.</br>
Case presentation</br>
A 69-year-old man presented with subfoveal retained PFCL after surgery for retinal detachment. To remove the retained PFCL, the internal limiting membrane overlying the subretinal injection site is first peeled to allow low-pressure (8 psi) transretinal BSS infusion, using a 41-gauge cannula, to slowly detach the macula. A small drainage retinotomy is created with the diathermy tip at the inferior position of the macular bleb, sized to be slightly wider than that of the PFCL droplet. The head of the bed is then raised, and the surgeon gently vibrates the patient’s head to release the PFCL droplet to allow it to migrate inferiorly towards the drainage retinotomy. The bed is returned to the horizontal position, and the PFCL, now on the retinal surface, can be aspirated. The subfoveal PFCL is removed while minimizing iatrogenic foveal and macular damage. One month after PFCL removal, the foveal structure showed partial recovery on optical coherence tomography, and BCVA improved to 20/40.</br>
Conclusion</br>
Creating a macular bleb with low infusion pressure and using vibrational forces and gravity to migrate the PFCL towards a retinotomy can be considered as a relatively atraumatic technique to remove subfoveal retained PFCL.
en-copyright=
kn-copyright=

en-aut-name=TakahashiKosuke
en-aut-sei=Takahashi
en-aut-mei=Kosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KimuraShuhei
en-aut-sei=Kimura
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HosokawaMio Morizane
en-aut-sei=Hosokawa
en-aut-mei=Mio Morizane
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShiodeYusuke
en-aut-sei=Shiode
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=DoiShinichiro
en-aut-sei=Doi
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatobaRyo
en-aut-sei=Matoba
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KanzakiYuki
en-aut-sei=Kanzaki
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YonekawaYoshihiro
en-aut-sei=Yonekawa
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MorizaneYuki
en-aut-sei=Morizane
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University
kn-affil=

affil-num=9
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Case report
kn-keyword=Case report
en-keyword=Perfluorocarbon
kn-keyword=Perfluorocarbon
en-keyword=Retinal detachment
kn-keyword=Retinal detachment
en-keyword=Subretinal injection
kn-keyword=Subretinal injection
en-keyword=Vitreoretinal surgery
kn-keyword=Vitreoretinal surgery
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=10
article-no=
start-page=e1009091
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201028
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Exploring the Complexity of Protein-Level Dosage Compensation that Fine-Tunes Stoichiometry of Multiprotein Complexes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Proper control of gene expression levels upon various perturbations is a fundamental aspect of cellular robustness. Protein-level dosage compensation is one mechanism buffering perturbations to stoichiometry of multiprotein complexes through accelerated proteolysis of unassembled subunits. Although N-terminal acetylation- and ubiquitin-mediated proteasomal degradation by the Ac/N-end rule pathway enables selective compensation of excess subunits, it is unclear how widespread this pathway contributes to stoichiometry control. Here we report that dosage compensation depends only partially on the Ac/N-end rule pathway. Our analysis of genetic interactions between 18 subunits and 12 quality control factors in budding yeast demonstrated that multiple E3 ubiquitin ligases and N-acetyltransferases are involved in dosage compensation. We find that N-acetyltransferases-mediated compensation is not simply predictable from N-terminal sequence despite their sequence specificity for N-acetylation. We also find that the compensation of Pop3 and Bet4 is due in large part to a minor N-acetyltransferase NatD. Furthermore, canonical NatD substrates histone H2A/H4 were compensated even in its absence, suggesting N-acetylation-independent stoichiometry control. Our study reveals the complexity and robustness of the stoichiometry control system. Author summary Quality control of multiprotein complexes is important for maintaining homeostasis in cellular systems that are based on functional complexes. Proper stoichiometry of multiprotein complexes is achieved by the balance between protein synthesis and degradation. Recent studies showed that translation efficiency tends to scale with stoichiometry of their subunits. On the other hand, although protein N-terminal acetylation- and ubiquitin-mediated proteolysis pathway is involved in selective degradation of excess subunits, it is unclear how widespread this pathway contributes to stoichiometry control due to the lack of a systematic investigation using endogenous proteins. To better understand the landscape of the stoichiometry control system, we examined genetic interactions between 18 subunits and 12 quality control factors (E3 ubiquitin ligases and N-acetyltransferases), in total 114 combinations. Our data suggest that N-acetyltransferases are partially responsible for stoichiometry control and that N-acetylation-independent pathway is also involved in selective degradation of excess subunits. Therefore, this study reveals the complexity and robustness of the stoichiometry control system. Further dissection of this complexity will help to understand the mechanisms buffering gene expression perturbations and shaping proteome stoichiometry.
en-copyright=
kn-copyright=

en-aut-name=IshikawaKoji
en-aut-sei=Ishikawa
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshiharaAkari
en-aut-sei=Ishihara
en-aut-mei=Akari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MoriyaHisao
en-aut-sei=Moriya
en-aut-mei=Hisao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Research Core for Interdisciplinary Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Course of Agrochemical Bioscience, Faculty of Agriculture, Okayama University
kn-affil=

affil-num=3
en-affil= Research Core for Interdisciplinary Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=5
article-no=
start-page=391
end-page=399
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202010
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Three-dimensional Evaluation of Abnormal Gait in Patients with Hip Osteoarthritis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Indexes for objectively evaluating abnormal gait in hip osteoarthritis (OA) patients and determining effective interventions are unclear. We analyzed the abnormal gait of hip OA patients by focusing on movements of the trunk and pelvis to establish an effective evaluation index for each direction of motion. We studied 28 patients with secondary hip OA due to developmental dysplasia of the hip and 16 controls. The trunk and pelvic movements during gait were measured in the medial-lateral (x), vertical (y), and back-and-forth (z) directions by a triaxial angular accelerometer. Gait speed, steps, step length, muscle strength, range of motion, and timed up-and-go (TUG) test performance were measured. We determined the correlations between physical function and the index of abnormal gait in the hip OA patients. Movements other than trunk and pelvic motions in the y-direction indicated abnormal gait in the patients. Significant correlations were found between abnormal gait and range of motions (extension, internal rotation), TUG score, stride length, and steps. The TUG test, stride length and steps were important for evaluating abnormal gait in hip OA patients. Individual interventions for each movement direction are required.
en-copyright=
kn-copyright=

en-aut-name=HommaDaisuke
en-aut-sei=Homma
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MinatoIzumi
en-aut-sei=Minato
en-aut-mei=Izumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ImaiNorio
en-aut-sei=Imai
en-aut-mei=Norio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MiyasakaDai
en-aut-sei=Miyasaka
en-aut-mei=Dai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SakaifYoshinori
en-aut-sei=Sakaif
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HorigomeYoji
en-aut-sei=Horigome
en-aut-mei=Yoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SuzukiHayato
en-aut-sei=Suzuki
en-aut-mei=Hayato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShimadaHayato
en-aut-sei=Shimada
en-aut-mei=Hayato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=DohmaeYoichiro
en-aut-sei=Dohmae
en-aut-mei=Yoichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=EndoNaoto
en-aut-sei=Endo
en-aut-mei=Naoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=2
en-affil=Division of Orthopedic Surgery, Niigata Rinko Hospital
kn-affil=

affil-num=3
en-affil=Division of Comprehensive Geriatrics in Community, Niigata University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=4
en-affil=Division of Orthopedic Surgery, Niigata Bandai Hospital
kn-affil=

affil-num=5
en-affil=Division of Orthopedic Surgery, Niigata General Hospital
kn-affil=

affil-num=6
en-affil=Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=7
en-affil=Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=8
en-affil=Division of Orthopedic Surgery, Mito Saiseikai General Hospital
kn-affil=

affil-num=9
en-affil=Division of Orthopedic Surgery, Niigata Bandai Hospital
kn-affil=

affil-num=10
en-affil=Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences
kn-affil=
en-keyword=hip osteoarthritis
kn-keyword=hip osteoarthritis
en-keyword=three-dimensional gait analysis
kn-keyword=three-dimensional gait analysis
en-keyword=abnormal gait
kn-keyword=abnormal gait
en-keyword=timed up and go test
kn-keyword=timed up and go test
en-keyword=range of motion
kn-keyword=range of motion
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=4
article-no=
start-page=275
end-page=283
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202008
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Decreased Serum Antioxidant Marker is Predictive of Early Recurrence in the Same Segment after Radical Ablation for Hepatocellular Carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment.
en-copyright=
kn-copyright=

en-aut-name=MuroTaiko
en-aut-sei=Muro
en-aut-mei=Taiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraShinichiro
en-aut-sei=Nakamura
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakakiAkinobu
en-aut-sei=Takaki
en-aut-mei=Akinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnishiHideki
en-aut-sei=Onishi
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WadaNozomu
en-aut-sei=Wada
en-aut-mei=Nozomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YasunakaTetsuya
en-aut-sei=Yasunaka
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=UchidaDaisuke
en-aut-sei=Uchida
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OyamaAtsushi
en-aut-sei=Oyama
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=AdachiTakuya
en-aut-sei=Adachi
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ShirahaHidenori
en-aut-sei=Shiraha
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=hepatocellular carcinoma
kn-keyword=hepatocellular carcinoma
en-keyword=recurrence,
kn-keyword=recurrence,
en-keyword=radiofrequency ablation
kn-keyword=radiofrequency ablation
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=1
article-no=
start-page=11
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200703
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Construction of IO Table in cities, towns, and villages: New Approach
kn-title=調査票情報を活用した市町村産業連関表の構築：New Approach
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　This paper proposes a new approach to construct IO Table called“ Reduced Form Approach.” There are a survey method and a non-survey method for constructing the regional input-output table. This paper proposes a hybrid approach that combines a survey method in terms of utilizing individual information and a survey method in the sense of conducting a questionnaire survey of business establishments.
　The most difficult part of constructing a regional input-output table is estimating the value of exports and imports. Furthermore, in an open regional economy, exports and imports have a large weight. In many of the conventional methods, the import/export rate was taken from the input-output table of the prefecture, and the import/export value was extracted as the residual of the expenditure balance. In this paper, we propose a “Reduced Form Approach” that reproduces the input-output table from the production induced value. This not only overcomes the difficulty of balance adjustment, but also realizes the visibility of simulation analysis using an input-output table.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=中村良平
kn-aut-sei=中村
kn-aut-mei=良平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=3
article-no=
start-page=215
end-page=220
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202006
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Exploring the Issues of Advance Directives in Patients with Mild Dementia in Taiwan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Due to cultural traditions, most Taiwanese do not have an advance directive or healthcare proxy. We explored how patients with mild dementia in Taiwan may still make self-determined decisions concerning advance directives for their healthcare and end-of-life care choices as the disease progresses. We examined 260 respondents with mild dementia at a Taiwan medical center: 199 patients who agreed (and 61 patients who disagreed) with the concept of advance directives completed a structured questionnaire. Multiple logistic regression models to determine the between-group differences revealed that the following were positively associated with approval of end-of-life directives: maintaining one’s quality of life (adjusted odds ratio [AOR], 2.44; 95% CI: 1.07-5.53), discussion with family members (AOR, 3.50; 95% CI: 1.49-8.26), and friend support networks (AOR, 3.36; 95% CI: 1.34-8.43). Cardiopulmonary resuscitation (AOR, 0.27; 95% CI: 0.09-0.79) was negatively associated with approval. There was also a positive association between the support of the legal validity of end-of-life directives (OR, 1.93; 95% CI: 1.07-3.48), without other confounding factors. In Taiwanese society, we remain mindful of cultural influences that may impact patients, including maintaining one’s quality of life, discussion with family members, and friend/support networks. These influences may help dementia patients complete their advance directives.
en-copyright=
kn-copyright=

en-aut-name=ChouHsi-Hsien
en-aut-sei=Chou
en-aut-mei=Hsi-Hsien
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=School of Medicine, Chung-Shan Medical University
kn-affil=
en-keyword=advance directive
kn-keyword=advance directive
en-keyword=dementia
kn-keyword=dementia
en-keyword=patient autonomy
kn-keyword=patient autonomy
en-keyword=quality of life
kn-keyword=quality of life
en-keyword=culture
kn-keyword=culture
END

start-ver=1.4
cd-journal=joma
no-vol=69
cd-vols=
no-issue=3
article-no=
start-page=356
end-page=369
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Japanese guidelines for atopic dermatitis 2020.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Atopic dermatitis (AD) is a disease characterized by relapsing eczema with pruritus as a primary lesion, which is frequently encountered in clinical practice. Skin barrier dysfunction leads to enhanced skin irritability to non-specific stimuli and epicutaneous sensitization. In the lesion site, a further inflammation-related reduction in skin barrier function, enhanced irritability and scratching-related stimuli deteriorate eczema, leading to vicious cycle of inflammation. The current strategies to treat AD in Japan from the perspective of evidence-based medicine consist of three primary measures: (i) the use of topical corticosteroids and tacrolimus ointment as the main treatment for the inflammation; (ii) topical application of emollients to treat the cutaneous barrier dysfunction; and (iii) avoidance of apparent exacerbating factors, psychological counseling and advice about daily life. The guidelines present recommendations to review clinical research articles, evaluate the balance between the advantages and disadvantages of medical activities, and optimize medical activity-related patient outcomes with respect to several important points requiring decision-making in clinical practice. 
en-copyright=
kn-copyright=

en-aut-name=KatohNorito
en-aut-sei=Katoh
en-aut-mei=Norito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhyaYukihiro
en-aut-sei=Ohya
en-aut-mei=Yukihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IkedaMasanori
en-aut-sei=Ikeda
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=EbiharaTamotsu
en-aut-sei=Ebihara
en-aut-mei=Tamotsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KatayamaIchiro
en-aut-sei=Katayama
en-aut-mei=Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SaekiHidehisa
en-aut-sei=Saeki
en-aut-mei=Hidehisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ShimojoNaoki
en-aut-sei=Shimojo
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TanakaAkio
en-aut-sei=Tanaka
en-aut-mei=Akio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NakaharaTakeshi
en-aut-sei=Nakahara
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=NagaoMizuho
en-aut-sei=Nagao
en-aut-mei=Mizuho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=HideMichihiro
en-aut-sei=Hide
en-aut-mei=Michihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=FujitaYuji
en-aut-sei=Fujita
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=FujisawaTakao
en-aut-sei=Fujisawa
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=FutamuraMasaki
en-aut-sei=Futamura
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=MasudaKoji
en-aut-sei=Masuda
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=MurotaHiroyuki
en-aut-sei=Murota
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=Yamamoto-HanadaKiwako
en-aut-sei=Yamamoto-Hanada
en-aut-mei=Kiwako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

affil-num=1
en-affil=Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science
kn-affil=

affil-num=2
en-affil=Allergy Center, National Center for Child Health and Development
kn-affil=

affil-num=3
en-affil=Department of Pediatric Acute Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Dermatology, Keio University School of Medicine
kn-affil=

affil-num=5
en-affil=Department of Dermatology, Graduate School of Medicine, Osaka University
kn-affil=

affil-num=6
en-affil=Department of Dermatology, Graduate School of Medicine, Nihon Medical School
kn-affil=

affil-num=7
en-affil=Department of Pediatrics, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=8
en-affil=Department of Dermatology, Hiroshima University Graduate School of Biomedical Sciences
kn-affil=

affil-num=9
en-affil=Division of Skin Surface Sensing, Department of Dermatology, Graduate School of Medical Sciences, Kyushu University
kn-affil=

affil-num=10
en-affil=Division of Clinical Research, National Hospital Organization Mie National Hospital
kn-affil=

affil-num=11
en-affil=Department of Dermatology, Hiroshima University Graduate School of Biomedical Sciences
kn-affil=

affil-num=12
en-affil=Department of Pediatrics, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=13
en-affil=Division of Allergy, National Hospital Organization Mie National Hospital
kn-affil=

affil-num=14
en-affil=Division of Pediatrics, National Hospital Organization Nagoya Medical Center
kn-affil=

affil-num=15
en-affil=Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science
kn-affil=

affil-num=16
en-affil=Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
kn-affil=

affil-num=17
en-affil=Allergy Center, National Center for Child Health and Development
kn-affil=
en-keyword=Atopic dermatitis
kn-keyword=Atopic dermatitis
en-keyword=Clinical practice guidelines
kn-keyword=Clinical practice guidelines
en-keyword=Eczema
kn-keyword=Eczema
en-keyword=Evidence-based medicine
kn-keyword=Evidence-based medicine
en-keyword=Treatment
kn-keyword=Treatment
END

start-ver=1.4
cd-journal=joma
no-vol=40
cd-vols=
no-issue=6
article-no=
start-page=3981
end-page=3995
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202006
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Axisymmetric traveling fronts in balanced bistable reaction-diffusion equations
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=For a balanced bistable reaction-diffusion equation, the existence of axisymmetric traveling fronts has been studied by Chen, Guo, Ninomiya, Hamel and Roquejoffre [4]. This paper gives another proof of the existence of axisymmetric traveling fronts. Our method is as follows. We use pyramidal traveling fronts for unbalanced reaction-diffusion equations, and take the balanced limit. Then we obtain axisymmetric traveling fronts in a balanced bistable reaction-diffusion equation. Since pyramidal traveling fronts have been studied in many equations or systems, our method might be applicable to study axisymmetric traveling fronts in these equations or systems.
en-copyright=
kn-copyright=

en-aut-name=TaniguchiMasaharu
en-aut-sei=Taniguchi
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil= Research Institute for Interdisciplinary Science, Okayama University
kn-affil=
en-keyword= Traveling front
kn-keyword= Traveling front
en-keyword= reaction-diffusion equation
kn-keyword= reaction-diffusion equation
en-keyword=axisymmetric
kn-keyword=axisymmetric
en-keyword=balanced
kn-keyword=balanced
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=10
article-no=
start-page=223
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191013
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Differential Response of Sugar Beet to Long-Term Mild to Severe Salinity in a Soil-Pot Culture
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Attempts to cultivate sugar beet (Beta vulgaris spp. vulgaris) in the sub-tropical saline soils are ongoing because of its excellent tolerance to salinity. However, the intrinsic adaptive physiology has not been discovered yet in the sub-tropical climatic conditions. In this study, we investigated morpho-physiological attributes, biochemical responses, and yield of sugar beet under a gradient of salinity in the soil-pot culture system to evaluate its adaptive mechanisms. Results exhibited that low and high salinity displayed a differential impact on growth, photosynthesis, and yield. Low to moderate salt stress (75 and 100 mM NaCl) showed no inhibition on growth and photosynthetic attributes. Accordingly, low salinity displayed simulative effect on chlorophyll and antioxidant enzymes activity which contributed to maintaining a balanced H2O2 accumulation and lipid peroxidation. Furthermore, relative water and proline content showed no alteration in low salinity. These factors contributed to improving the yield (tuber weight). On the contrary, 250 mM salinity showed a mostly inhibitory role on growth, photosynthesis, and yield. Collectively, our findings provide insights into the mild-moderate salt adaptation strategy in the soil culture test attributed to increased water content, elevation of photosynthetic pigment, better photosynthesis, and better management of oxidative stress. Therefore, cultivation of sugar beet in moderately saline-affected soils will ensure efficient utilization of lands.
en-copyright=
kn-copyright=

en-aut-name=Tahjib-UI-ArifMd.
en-aut-sei=Tahjib-UI-Arif
en-aut-mei=Md.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SohagAbdullah Al Mamun
en-aut-sei=Sohag
en-aut-mei=Abdullah Al Mamun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AfrinSonya
en-aut-sei=Afrin
en-aut-mei=Sonya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=BasharKazi Khayrul
en-aut-sei=Bashar
en-aut-mei=Kazi Khayrul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AfrinTania
en-aut-sei=Afrin
en-aut-mei=Tania
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MahamudA. G. M. Sofi Uddin
en-aut-sei=Mahamud
en-aut-mei=A. G. M. Sofi Uddin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=PolashMohammed Arif Sadik
en-aut-sei=Polash
en-aut-mei=Mohammed Arif Sadik
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HossainMd. Tahmeed
en-aut-sei=Hossain
en-aut-mei=Md. Tahmeed
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SohelMd. Abu Taher
en-aut-sei=Sohel
en-aut-mei=Md. Abu Taher
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=BresticMarian
en-aut-sei=Brestic
en-aut-mei=Marian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Biochemistry and Molecular Biology, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Bangladesh Jute Research Institute
kn-affil=

affil-num=5
en-affil=Graduate Training Institute, Bangladesh Agricultural University
kn-affil=

affil-num=6
en-affil=Food Biochemistry Laboratory, Department of Biochemistry and Molecular Biology, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=7
en-affil=Department of Crop Botany, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=8
en-affil=Department of Biochemistry and Molecular Biology, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=9
en-affil=Agronomy and Farming System Division, Bangladesh Sugar Crop Research Institute
kn-affil=

affil-num=10
en-affil=Department of Plant Physiology, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture
kn-affil=

affil-num=11
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=antioxidant enzymes
kn-keyword=antioxidant enzymes
en-keyword=photosynthesis
kn-keyword=photosynthesis
en-keyword=reactive oxygen species
kn-keyword=reactive oxygen species
en-keyword=salinity
kn-keyword=salinity
en-keyword=sugar beet
kn-keyword=sugar beet
en-keyword=yield
kn-keyword=yield
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=12
article-no=
start-page=1007
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191121
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Relationship between Uterine, Fecal, Bedding, and Airborne Dust Microbiota from Dairy Cows and Their Environment: A Pilot Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Simple Summary After calving, dairy cows face the risk of negative energy balance, inflammation, and immunosuppression, which may result in bacterial infection and disruption of the normal microbiota, thus encouraging the development of metritis and endometritis. This study characterized uterine, fecal, bedding, and airborne dust microbiota from postpartum dairy cows and their environment during summer and winter. The results clarify the importance of microbiota in cowshed environments, i.e., bedding and airborne dust, in understanding the postpartum uterine microbiota of dairy cows. <br/><br/>
Abstract The aim of this study was to characterize uterine, fecal, bedding, and airborne dust microbiota from postpartum dairy cows and their environment. The cows were managed by the free-stall housing system, and samples for microbiota and serum metabolite assessment were collected during summer and winter when the cows were at one and two months postpartum. Uterine microbiota varied between seasons; the five most prevalent taxa were Enterobacteriaceae, Moraxellaceae, Ruminococcaceae, Staphylococcaceae, and Lactobacillaceae during summer, and Ruminococcaceae, Lachnospiraceae, Bacteroidaceae, Moraxellaceae, and Clostridiaceae during winter. Although Actinomycetaceae and Mycoplasmataceae were detected at high abundance in several uterine samples, the relationship between the uterine microbiota and serum metabolite concentrations was unclear. The fecal microbiota was stable regardless of the season, whereas bedding and airborne dust microbiota varied between summer and winter. With regards to uterine, bedding, and airborne dust microbiota, Enterobacteriaceae, Moraxellaceae, Staphylococcaceae, and Lactobacillaceae were more abundant during summer, and Ruminococcaceae, Lachnospiraceae, Bacteroidaceae, and Clostridiaceae were more abundant during winter. Canonical analysis of principal coordinates confirmed the relationship between uterine and cowshed microbiota. These results indicated that the uterine microbiota may vary when the microbiota in cowshed environments changes.
en-copyright=
kn-copyright=

en-aut-name=NguyenThuong T.
en-aut-sei=Nguyen
en-aut-mei=Thuong T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyakeAyumi
en-aut-sei=Miyake
en-aut-mei=Ayumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TranTu T. M.
en-aut-sei=Tran
en-aut-mei=Tu T. M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TsurutaTakeshi
en-aut-sei=Tsuruta
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NishinoNaoki
en-aut-sei=Nishino
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Okayama Prefecture Livestock Research Institute
kn-affil=

affil-num=3
en-affil=Faculty of Agriculture and Food Technology, Tien Giang University
kn-affil=

affil-num=4
en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=cowshed
kn-keyword=cowshed
en-keyword=environment
kn-keyword=environment
en-keyword=microbiota
kn-keyword=microbiota
en-keyword=uterus
kn-keyword=uterus
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=12
article-no=
start-page=125317
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Magnetic characterization change by solvents of magnetic nanoparticles in liquid-phase magnetic immunoassay
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Liquid-phase magnetic immunoassay (MIA) using magnetic nano-particles (MNPs) has been studied as a more rapid method compared to optical methods for inspecting proteins and viruses. MIA can estimate the number of conjugated antibodies without being washed differently from conventional optical immunoassay. However, in the case of the liquid phase, it is considered that the magnetic properties of MNPs are affected by physical properties such as viscosity and impurity substances such as biological substances contained in the blood. In this study, the effect of sodium chloride (NaCl) in buffer and serum solution was evaluated to reveal the effect of serum because the sodium (Na+) and chloride (Cl-) ions in the serum dominate ion balance of blood. The measurement results of AC magnetic susceptibility and a dynamic light scattering (DLS) showed that the aggregation of MNPs was largely affected by the concentration of NaCl. This effect of the NaCl could be explained by shielding of the surface charge of MNPs by ions in the solution. Although the concentrations of NaCl in the buffer and serum solution were almost same, we found that MNPs were aggregated more in their size for those in the serum solution because of other impurities, such as proteins. These results suggest evaluation of effects of the contaminants in serum and optimization of polymer coatings of MNPs could be important factors to realize measurements of magnetic immunoassay with high accuracy. (C) 2019 Author(s).
en-copyright=
kn-copyright=

en-aut-name=JinnoKatsuya
en-aut-sei=Jinno
en-aut-mei=Katsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HiramatsuBunta
en-aut-sei=Hiramatsu
en-aut-mei=Bunta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TsunashimaKenta
en-aut-sei=Tsunashima
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FujimotoKayo
en-aut-sei=Fujimoto
en-aut-mei=Kayo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SakaiKenji
en-aut-sei=Sakai
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KiwaToshihiko
en-aut-sei=Kiwa
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TsukadaKeiji
en-aut-sei=Tsukada
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=6
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202002
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Promising New Anti-Cancer Strategy: Iron Chelators Targeting CSCs
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings.
en-copyright=
kn-copyright=

en-aut-name=ChenYuehua
en-aut-sei=Chen
en-aut-mei=Yuehua
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OharaToshiaki
en-aut-sei=Ohara
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=XingBoyi
en-aut-sei=Xing
en-aut-mei=Boyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=QiJiping
en-aut-sei=Qi
en-aut-mei=Jiping
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NomaKazuhiro
en-aut-sei=Noma
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsukawaAkihiro
en-aut-sei=Matsukawa
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Pathology, the First Affiliated Hospital of Harbin Medical University
kn-affil=

affil-num=5
en-affil=Department of  Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=cancer stem cell
kn-keyword=cancer stem cell
en-keyword=stemness
kn-keyword=stemness
en-keyword=iron
kn-keyword=iron
en-keyword=chelation
kn-keyword=chelation
en-keyword=chemotherapy
kn-keyword=chemotherapy
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=2
article-no=
start-page=113
end-page=118
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20181204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Social problems in daily life of patients with dementia
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=AIM:<br/>
Most patients with dementia frequently encounter various problems in their daily lives. Those troubles embarrass both the patients and their families, and cause problems for society. However, there have been few scientific reports on the difficulties in the daily life of patients with dementia. Therefore, we tried to clarify the frequency and characteristics of troubles experienced by patients with dementia.<br/>
METHODS:<br/>
Seven medical centers treating dementia patients in Okayama Prefecture, Japan, participated in this survey. A total of 737 patients were placed in one of the three groups: a dementia group (n = 478), a mild cognitive impairment group (n = 199) and a control group (n = 60). The frequency of 13 difficulties was scored for each patient.<br/>
RESULTS:<br/>
Among normal participants, no person caused these problems once a year or more frequently. "Massive, recurrent buying" and "acts that risk causing a fire" were reported once a year or more for >10% of mild cognitive impairment patients. "Troubles with wealth management" and "troubles with money management" were the most frequent problems of dementia patients.<br/>
CONCLUSIONS:<br/>
Several problems are already sometimes encountered in patients with mild cognitive impairment. It would be useful to know which social difficulties are often seen in dementia patients in order to protect the safety of the patients. It is always difficult to balance respecting the autonomy of dementia patients and ensuring their safely. 
en-copyright=
kn-copyright=

en-aut-name=TeradaSeishi
en-aut-sei=Terada
en-aut-mei=Seishi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakashimaMakoto
en-aut-sei=Nakashima
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WakutaniYosuke
en-aut-sei=Wakutani
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakataKenji
en-aut-sei=Nakata
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KutokuYumiko
en-aut-sei=Kutoku
en-aut-mei=Yumiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SunadaYoshihide
en-aut-sei=Sunada
en-aut-mei=Yoshihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KondoKeiko
en-aut-sei=Kondo
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IshizuHideki
en-aut-sei=Ishizu
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YokotaOsamu
en-aut-sei=Yokota
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MakiYohko
en-aut-sei=Maki
en-aut-mei=Yohko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=HattoriHideyuki
en-aut-sei=Hattori
en-aut-mei=Hideyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=YamadaNorihito
en-aut-sei=Yamada
en-aut-mei=Norihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Psychiatry, Okayama Red Cross Hospital
kn-affil=

affil-num=3
en-affil=Department of Neurology, Kurashiki Heisei Hospital
kn-affil=

affil-num=4
en-affil=Department of Psychiatry, Taiyo Hills Hospital
kn-affil=

affil-num=5
en-affil= Department of Neurology, Kawasaki Medical School
kn-affil=

affil-num=6
en-affil= Department of Neurology, Kawasaki Medical School
kn-affil=

affil-num=7
en-affil=Department of Psychiatry, Sekizen Hospital
kn-affil=

affil-num=8
en-affil=Department of Psychiatry, Zikei Hospital
kn-affil=

affil-num=9
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine
kn-affil=

affil-num=10
en-affil=Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology
kn-affil=

affil-num=11
en-affil=Department of Psychiatry, National Hospital for Geriatric Medicine, NCGG
kn-affil=

affil-num=12
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine
kn-affil=
en-keyword=daily life
kn-keyword=daily life
en-keyword=dementia
kn-keyword=dementia
en-keyword=mild cognitive impairment
kn-keyword=mild cognitive impairment
en-keyword=sex
kn-keyword=sex
en-keyword=trouble
kn-keyword=trouble
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=1
article-no=
start-page=10956
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190729
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=In vivo direct reprogramming of glial linage to mature neurons after cerebral ischemia
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The therapeutic effect of in vivo direct reprogramming on ischemic stroke has not been evaluated. In the present study, a retroviral solution (1.5-2.0 × 107 /ul) of mock pMX-GFP (n = 13) or pMX-Ascl1/Sox2/NeuroD1 (ASN) (n = 14) was directly injected into the ipsilateral striatum and cortex 3 days after 30 min of transient cerebral ischemia. The reprogrammed cells first expressed neuronal progenitor marker Dcx 7 and 21 days after viral injection, then expressed mature neuronal marker NeuN. This was accompanied by morphological changes, including long processes and synapse-like structures, 49 days after viral injection. Meanwhile, therapeutic improvement was not detected both in clinical scores or infarct volume. The present study provides a future novel self-repair strategy for ischemic stroke with beneficial modifications of the inducer-suppressor balance.
en-copyright=
kn-copyright=

en-aut-name=YamashitaToru
en-aut-sei=Yamashita
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShangJingwei
en-aut-sei=Shang
en-aut-mei=Jingwei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakanoYumiko
en-aut-sei=Nakano
en-aut-mei=Yumiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MoriharaRyuta
en-aut-sei=Morihara
en-aut-mei=Ryuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SatoKota
en-aut-sei=Sato
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TakemotoMami
en-aut-sei=Takemoto
en-aut-mei=Mami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HishikawaNozomi
en-aut-sei=Hishikawa
en-aut-mei=Nozomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OhtaYasuyuki
en-aut-sei=Ohta
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=AbeKoji
en-aut-sei=Abe
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=6
article-no=
start-page=547
end-page=552
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Phase II Study of Treatment for Newly Diagnosed Multiple Myeloma Patients Over 75 Years Old with Alternating Bortezomib/dexamethasone and Lenalidomide/dexamethasone: the MARBLE Trial
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Elderly multiple myeloma (MM) patients, who are generally ineligible for transplantation, have high risks of death and treatment discontinuation, and require a regimen incorporating novel agents that balance safety, tolerability, and efficacy. We evaluated alternating bortezomib-dexamethasone and lenalidomide-dexamethasone treatments administered over a 63-day cycle in transplant-ineligible elderly patients with newly diagnosed MM. Subcutaneous bortezomib 1.3 mg/m2 was administered weekly on Days 1, 8, 15, and 22; oral lenalidomide 15 mg daily on Days 36-56; and oral dexamethasone 20 mg on Days 1, 8, 15, 22, 36, 43, 50, and 57 for 6 cycles. The primary endpoint was the overall response rate.
en-copyright=
kn-copyright=

en-aut-name=YokoyamaAkihiro
en-aut-sei=Yokoyama
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KadaAkiko
en-aut-sei=Kada
en-aut-mei=Akiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SaitoAkiko M.
en-aut-sei=Saito
en-aut-mei=Akiko M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SawamuraMorio
en-aut-sei=Sawamura
en-aut-mei=Morio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KomenoTakuya
en-aut-sei=Komeno
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SunamiKazutaka
en-aut-sei=Sunami
en-aut-mei=Kazutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakezakoNaoki
en-aut-sei=Takezako
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Division of Hematology, Department of Internal Medicine, NHO Tokyo Medical Center
kn-affil=

affil-num=2
en-affil=Department of Clinical Trials and Research, Clinical Research Center, NHO Nagoya Medical Center
kn-affil=

affil-num=3
en-affil=Department of Clinical Trials and Research, Clinical Research Center, NHO Nagoya Medical Center
kn-affil=

affil-num=4
en-affil=Department of Hematology, NHO Shibukawa Medical Center
kn-affil=

affil-num=5
en-affil=Department of Hematology, NHO Mito Medical Center
kn-affil=

affil-num=6
en-affil=Department of Hematology, NHO Okayama Medical Center
kn-affil=

affil-num=7
en-affil=Department of Hematology, Disaster Medical Center of Japan
kn-affil=
en-keyword=bortezomib
kn-keyword=bortezomib
en-keyword=lenalidomide
kn-keyword=lenalidomide
en-keyword=dexamethasone
kn-keyword=dexamethasone
en-keyword=myeloma
kn-keyword=myeloma
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=11
article-no=
start-page=1001
end-page=1007
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191005
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Yoga-plus exercise mix promotes cognitive, affective, and physical functions in elderly people
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objectives: <br/>
Increased attention is being paid to Asian medicine in balanced total health care. We investigated the effects of mixed exercise including yoga ('Yoga-plus') among elderly individuals. <br/>
Methods: <br/>
A total of 385 subjects (72 males and 313 females, 75.5 ± 8.7 years old) participated in a 12-month (M) exercise program at a health and welfare center, a day service center, and a nursing home. Cognitive, affective, and physical functions, and activities of daily living (ADL), were compared at baseline (0M), 6M and 12M of exercise intervention. <br/>
Results: <br/>
Mean scores on the frontal assessment battery, clock drawing test, cube copying test, letter fluency, and category fluency significantly improved after the Yoga-plus intervention, while mini-mental state examination, Hasegawa dementia score-revised, and trail-making test performance were relatively stable. Affective scores on the geriatric depression scale (GDS), apathy scale (AS) and Abe's behavioral and psychological symptoms of dementia were not significantly affected by exercise therapy, but subgroups with higher baseline GDS (GDS ≥ 5) and AS (AS ≥ 16) scores showed a significant improvement after intervention. One-leg standing time and 3-m timed up and go test performance significantly improved after 12M intervention. <br/>
Discussion: <br/>
Yoga-plus improved cognitive, affective, ADL, and physical functions in a local elderly population, particularly among below-baseline individuals, indicating the benefits of dementia prevention among elderly individuals.
en-copyright=
kn-copyright=

en-aut-name=HishikawaNozomi
en-aut-sei=Hishikawa
en-aut-mei=Nozomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakahashiYoriko
en-aut-sei=Takahashi
en-aut-mei=Yoriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FukuiYusuke
en-aut-sei=Fukui
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TokuchiRyo
en-aut-sei=Tokuchi
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FurusawaJunichi
en-aut-sei=Furusawa
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TakemotoMami
en-aut-sei=Takemoto
en-aut-mei=Mami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SatoKota
en-aut-sei=Sato
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YamashitaToru
en-aut-sei=Yamashita
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OhtaYasuyuki
en-aut-sei=Ohta
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=AbeKoji
en-aut-sei=Abe
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Education, Nippon Ayurveda School
kn-affil=

affil-num=3
en-affil= Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Occupational Therapy, Okayama Institute for Medical and Technical Sciences
kn-affil=

affil-num=5
en-affil=Department of Occupational Therapy, Mizunaga Rehabilitation Hospital 
kn-affil=

affil-num=6
en-affil= Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil= Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil= Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil= Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil= Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Affective function
kn-keyword=Affective function
en-keyword=cognitive function
kn-keyword=cognitive function
en-keyword=elderly population
kn-keyword=elderly population
en-keyword=physical function
kn-keyword=physical function
en-keyword=yoga exercise
kn-keyword=yoga exercise
END

start-ver=1.4
cd-journal=joma
no-vol=36
cd-vols=
no-issue=7
article-no=
start-page=1791
end-page=1816
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190527
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Axially asymmetric traveling fronts in balanced bistable reaction-diffusion equations
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= For a balanced bistable reaction-diffusion equation, an axisymmetric traveling front has been well known. This paper proves that an axially asymmetric traveling front with any positive speed does exist in a balanced bistable reaction-diffusion equation. Our method is as follows. We use a pyramidal traveling front for an unbalanced reaction-diffusion equation whose cross section has a major axis and a minor axis. Preserving the ratio of the major axis and a minor axis to be a constant and taking the balanced limit, we obtain a traveling front in a balanced bistable reaction-diffusion equation. This traveling front is monotone decreasing with respect to the traveling axis, and its cross section is a compact set with a major axis and a minor axis when the constant ratio is not 1.
en-copyright=
kn-copyright=

en-aut-name=TaniguchiMasaharu
en-aut-sei=Taniguchi
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=
en-keyword=Traveling front
kn-keyword=Traveling front
en-keyword=Reaction-diffusion equation
kn-keyword=Reaction-diffusion equation
en-keyword=Asymmetric
kn-keyword=Asymmetric
en-keyword=Balanced
kn-keyword=Balanced
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=2
article-no=
start-page=173
end-page=176
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201904
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Successful Delivery after Abdominal Radical Trachelectomy, Using Transabdominal Cerclage in Early Pregnancy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Radical trachelectomy (RT) is a fertility-sparing surgery for cervical cancer. Postoperative pregnancies have a high risk of abortion and prematurity. To prevent this, a procedure involving transabdominal cerclage (TAC) was devised for shortened cervical canals post-RT. Here we describe the successful management of a pregnancy after abdominal RT (ART). The 34-year-old patient was gravida 1, para 0. When she was 27, she underwent ART for stage Ib1 cervical cancer, and she became pregnant 7 years later. Because her cervical canal was 16.7 mm during early pregnancy, we performed TAC at 12 weeks of pregnancy. Post-surgery, we administered an infusion of ritodrine hydrochloride for tocolysis. A selective caesarean section was performed at 36 weeks, with the delivery of a healthy infant.
en-copyright=
kn-copyright=

en-aut-name=TamadaShoko
en-aut-sei=Tamada
en-aut-mei=Shoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MasuyamaHisashi
en-aut-sei=Masuyama
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HayataKei
en-aut-sei=Hayata
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=EtoEriko
en-aut-sei=Eto
en-aut-mei=Eriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MitsuiTakashi
en-aut-sei=Mitsui
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=EguchiTakeshi
en-aut-sei=Eguchi
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MakiJota
en-aut-sei=Maki
en-aut-mei=Jota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TaniKazumasa
en-aut-sei=Tani
en-aut-mei=Kazumasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Departments of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=2
en-affil=Departments of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=3
en-affil=Departments of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=4
en-affil=Departments of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=5
en-affil=Departments of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=6
en-affil=Departments of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=7
en-affil=Departments of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=8
en-affil=Departments of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=
en-keyword=cervical cancer
kn-keyword=cervical cancer
en-keyword=radical trachelectomy
kn-keyword=radical trachelectomy
en-keyword=pregnancy
kn-keyword=pregnancy
en-keyword=transabdominal cerclage
kn-keyword=transabdominal cerclage
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=2
article-no=
start-page=101
end-page=107
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201904
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Factors Affecting the Absorption of Midazolam to the Extracorporeal Membrane Oxygenation Circuit
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Sedatives are administered during extracorporeal membrane oxygenation (ECMO) therapy to ensure patient safety, reduce the metabolic rate and correct the oxygen supply-demand balance. However, the concentrations of sedatives can be decreased due to absorption into the circuit. This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Using multiple ex vivo simulation models, three factors that may influence MDZ levels in the ECMO circuit were examined: polyvinyl chloride (PVC) tubing in the circuit, use of a membrane oxygenator in the circuit, and heparin coating of the circuit. We also assessed changes in drug concentration when MDZ was re-injected in a circuit. The MDZ level decreased to approximately 60% of the initial concentration in simulated circuits within the first 30 minutes. The strongest factor in this phenomenon was contact with the PVC tubing. Membrane oxygenator use tended to increase MDZ loss, whereas heparin circuit coating had no influence on MDZ absorption. Similar results were obtained when a second dose of MDZ was injected to the second-use circuits.
en-copyright=
kn-copyright=

en-aut-name=IidaAtsuyoshi
en-aut-sei=Iida
en-aut-mei=Atsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ZamamiYoshito
en-aut-sei=Zamami
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamadaAkane
en-aut-sei=Yamada
en-aut-mei=Akane
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KogaTadashi
en-aut-sei=Koga
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ImaiToru
en-aut-sei=Imai
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=IchibaShingo
en-aut-sei=Ichiba
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Emergency and Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Emergency and Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Human Ecology, Okayama University Graduate School of Environmental and Life Science
kn-affil=

affil-num=4
en-affil=Department of Clinical Pharmacy, Institute of Biomedical Sciences, Tokushima University Graduate School
kn-affil=

affil-num=5
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.
kn-affil=

affil-num=7
en-affil=Department of Pharmacy, Nihon University Itabashi Hospital
kn-affil=

affil-num=8
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Emergency and Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Surgical Intensive Care Medicine, Nippon Medical School Hospital
kn-affil=
en-keyword=sedatives
kn-keyword=sedatives
en-keyword=ECMO
kn-keyword=ECMO
en-keyword=polyvinyl chloride
kn-keyword=polyvinyl chloride
en-keyword=pharmacokinetics
kn-keyword=pharmacokinetics
en-keyword=pharmacodynamics
kn-keyword=pharmacodynamics
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=2
article-no=
start-page=95
end-page=100
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201904
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of Self-perceived Fatigue on Balance and Functional Mobility in Middle-Aged Obese Women
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The aim of this study was to examine effect of fatigue levels on functional mobility and balance in middle-aged obese females. The study included 98 healthy females aged 40-60 years with BMI ≥ 30 kg/m2. Self-perceived fatigue was evaluated with a self-administered questionnaire, the Checklist of Individual Strength in Turkish (CIS-T), on which 62.3% of the study subjects identified themselves as fatigued. The body weight and BMI values of fatigued subjects were found to be higher than those of the non-fatigue group (p<0.05). The reported exercise habits of the fatigue group were found to be significantly lower than their non-fatigued peers (p<0.05). The level of functional mobility (Timed Up and Go Test), static balance (One-Legged Stance Test with Eyes Open) and dynamic balance (Functional Reach Test and the 3-meter Timed Tandem Walk Test) were measured, and statistically significant differences were found between fatigue and non-fatigue groups on all of them (p<0.05). In addition, correlations were found between the sub-parameters of the CIS-T scale and the functional tests at
en-copyright=
kn-copyright=

en-aut-name=ErcanSabriye
en-aut-sei=Ercan
en-aut-mei=Sabriye
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=Başkurt Ferdi
en-aut-sei=Başkurt
en-aut-mei= Ferdi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=BaşkurtZeliha
en-aut-sei=Başkurt
en-aut-mei=Zeliha
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ÇetinCem
en-aut-sei=Çetin
en-aut-mei=Cem
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Sports Medicine, Suleyman Demirel University, Medicine Faculty, Sports Medicine Department
kn-affil=

affil-num=2
en-affil=Department of Physiotherapy and Rehabilitation, Suleyman Demirel University, Health Sciences Faculty
kn-affil=

affil-num=3
en-affil=Department of Physiotherapy and Rehabilitation, Suleyman Demirel University, Health Sciences Faculty
kn-affil=

affil-num=4
en-affil=Department of Sports Medicine, Suleyman Demirel University, Medicine Faculty
kn-affil=
en-keyword=fatigue
kn-keyword=fatigue
en-keyword=obesity
kn-keyword=obesity
en-keyword=mobility
kn-keyword=mobility
en-keyword=balance
kn-keyword=balance
en-keyword=woman
kn-keyword=woman
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=1
article-no=
start-page=29
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Histidine-rich Glycoprotein Could Be an Early Predictor of Vasospasm after Aneurysmal Subarachnoid Hemorrhage
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoAtsushi
en-aut-sei=Matsumoto
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraTakehiro
en-aut-sei=Nakamura
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShinomiyaAya
en-aut-sei=Shinomiya
en-aut-mei=Aya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KawakitaKenya
en-aut-sei=Kawakita
en-aut-mei=Kenya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawanishiMasahiko
en-aut-sei=Kawanishi
en-aut-mei=Masahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiyakeKeisuke
en-aut-sei=Miyake
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KurodaYasuhiro
en-aut-sei=Kuroda
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KeepRichard F.
en-aut-sei=Keep
en-aut-mei=Richard F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TamiyaTakashi
en-aut-sei=Tamiya
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=2
en-affil=Department of Medical Technology, Kagawa Prefectural University of Health Sciences
kn-affil=

affil-num=3
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=4
en-affil=Emergency Medical Center, Kagawa University Hospital
kn-affil=

affil-num=5
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=6
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=7
en-affil=Emergency Medical Center, Kagawa University Hospital
kn-affil=

affil-num=8
en-affil=Department of Neurosurgery, University of Michigan
kn-affil=

affil-num=9
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=
en-keyword=biomarker
kn-keyword=biomarker
en-keyword=histidine-rich glycoprotein
kn-keyword=histidine-rich glycoprotein
en-keyword=predictor
kn-keyword=predictor
en-keyword=subarachnoid hemorrhage
kn-keyword=subarachnoid hemorrhage
en-keyword=vasospasm
kn-keyword=vasospasm
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=4
article-no=
start-page=407
end-page=417
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=201808
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of Gait Rehabilitation System Capable of Assisting Pelvic Movement of Normal Walking
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Gait rehabilitation training with robotic exoskeleton is drawing attention as a method for more advanced gait rehabilitation training. However, most of the rehabilitation robots are mainly focused on locomotion training in the sagittal plane. This study introduces a novel gait rehabilitation system with actuated pelvic motion to generate natural gait motion. The rehabilitation robot developed in this study, COWALK, is a lower-body exoskeleton system with 15 degrees of freedom (DoFs). The COWALK can generate multi-DoF pelvic movement along with leg movements. To produce natural gait patterns, the actuation of pelvic movement is essential. In the COWALK, the pelvic movement mechanism is designed to help hemiplegic patients regain gait balance during gait training. To verify the effectiveness of the developed system, the gait patterns with and without pelvic movement were compared to the normal gait on a treadmill. The experimental results show that the active control of pelvic movement combined with the active control of leg movement can make the gait pattern much more natural.
en-copyright=
kn-copyright=

en-aut-name=JungChanyul
en-aut-sei=Jung
en-aut-mei=Chanyul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=JungSuhun
en-aut-sei=Jung
en-aut-mei=Suhun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ChunMin Ho
en-aut-sei=Chun
en-aut-mei=Min Ho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=LeeJong Min
en-aut-sei=Lee
en-aut-mei=Jong Min
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ParkShinsuk
en-aut-sei=Park
en-aut-mei=Shinsuk
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KimSeung-Jong
en-aut-sei=Kim
en-aut-mei=Seung-Jong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Mechanical Engineering, Korea University
kn-affil=

affil-num=2
en-affil=Department of Mechanical Engineering, Korea University
kn-affil=

affil-num=3
en-affil=Department of Physical Medicine and Rehabilitation, Asan Medical Center, College of Medicine, University of Ulsan
kn-affil=

affil-num=4
en-affil=Center for Bionics, Korea Institute of Science and Technology
kn-affil=

affil-num=5
en-affil=Department of Mechanical Engineering, Korea University
kn-affil=

affil-num=6
en-affil=Department of Biomedical Engineering, College of Medicine, Korea University
kn-affil=
en-keyword=exoskeleton
kn-keyword=exoskeleton
en-keyword=gait rehabilitation
kn-keyword=gait rehabilitation
en-keyword=balance control
kn-keyword=balance control
en-keyword=pelvic movement
kn-keyword=pelvic movement
en-keyword=gravity compensation
kn-keyword=gravity compensation
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=4
article-no=
start-page=359
end-page=367
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=201808
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Upregulation of Angiogenic Factors via Protein Kinase C and Hypoxia-induced Factor-1α Pathways under High-glucose Conditions in the Placenta
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Abnormal glucose metabolism during pregnancy is an established risk factor for preeclampsia (PE). Disruption of the balance between placental angiogenic factors is linked to PE pathophysiology. We examined whether hypoxia-induced factor-1α (HIF-1α) and protein kinase Cβ (PKCβ) are involved in the regulation of placental angiogenic factors under high-glucose conditions in vitro. The human choriocarcinoma cell lines BeWo and JEG-3, and the human trophoblast cell line HTR-8/SVneo were cultured with 10 and 25 mmol/L glucose [control glucose group (CG) and high-glucose group (HG), respectively]. We examined the changes in HIF-1α, soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) expression in the CG and HG by real-time PCR and ELISA. PKC activation was also measured by ELISA. The expressions of HIF-1α, sFlt-1, PlGF, and VEGF were significantly higher in the HG than in the CG. PKC activity was significantly increased in the HG. High glucose affected the expression of angiogenic factors in choriocarcinoma cells via the PKCβ and HIF-1α pathways, suggesting their involvement in PE pathogenesis.
en-copyright=
kn-copyright=

en-aut-name=MitsuiTakashi
en-aut-sei=Mitsui
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TaniKazumasa
en-aut-sei=Tani
en-aut-mei=Kazumasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Maki Jota
en-aut-sei=Maki
en-aut-mei= Jota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=EguchiTakeshi
en-aut-sei=Eguchi
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TamadaShoko
en-aut-sei=Tamada
en-aut-mei=Shoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=EtoEriko
en-aut-sei=Eto
en-aut-mei=Eriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HayataKei
en-aut-sei=Hayata
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MasuyamaHisashi
en-aut-sei=Masuyama
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=high-glucose condition
kn-keyword=high-glucose condition
en-keyword= preeclampsia
kn-keyword= preeclampsia
en-keyword=protein kinase C
kn-keyword=protein kinase C
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=2型糖尿病患者に対する非外科的歯周治療による血糖コントロール、酸化ストレス、QOLへの影響 : ランダム化比較試験による検討
kn-title=The effects of non-surgical periodontal treatment on glycemic control, oxidative stress balance and quality of life in patients with type 2 diabetes: A randomized clinical trial
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MizunoHirofumi
en-aut-sei=Mizuno
en-aut-mei=Hirofumi
kn-aut-name=水野裕文
kn-aut-sei=水野
kn-aut-mei=裕文
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=1
article-no=
start-page=10
end-page=17
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201712
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Discovery Program for Global Learners at Okayama University and IB Education: Reflections on My University Experiences in Japan and the United States of America
kn-title=岡山大学の「グローバル・ディスカバリー・プログラム」とIB教育 : 文化人類学者としての日米での取り組みへの「振り返り」
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= As a cultural anthropologist, I discovered the affinity between my teaching philosophy and IB education that values reflexivity. Educating students to become reflective critical thinkers is also the shared goal of the liberal arts colleges I had taught at for over a decade in the United States.
　I decided to come back to Japan from the United States in 2015 when I was given an opportunity to pursue such education in a more affordable way at a Japanese national university. Due to the nature of labor-intensive and quality education, both liberal arts colleges and IB schools often ask high tuitions. Compare to the expensive private liberal arts colleges in the United States, the tuition of a Japanese national university is more affordable.
　As the first Japanese national university, which started the special entrance examination for students with IB Diploma, Okayama University started the new English-medium college-degree program called Discovery Program for Global Learners (Hereafter, Discovery Program) in 2017. The program pursues diversity and social innovation for global sustainability while offering affordable higher education in English (and in Japanese for those with Japanese proficiency).
　In this paper, I compare and contrast U.S. higher education (liberal arts college in particular) and the Discovery Program at Okayama University while paying attention to IB Learner Profile Attributes : Inquirers, Knowledgeable, Thinkers, Communicators, Principles, Open-Minded, Caring, Risk-Takers, Balanced, and Reflective. Some (if not all) elements of the profile are shared with many U.S. liberal arts colleges’ mission statements. As one of the founding members of the Discovery Program and the first faculty member hired for this program, I have been trying to incorporate many of the above elements into the Discovery Program.
　In order to encourage students to become knowledgeable, open-minded, caring, balanced, and reflective inquirers, thinkers, communicators, principled, and risk-takers, institutional environment is crucial. No matter how much students are taught to become the above type of person, if faculty, staff, and administrators behave otherwise, students get confused, lose trust in them, or both. Even if the faculty, staff, and administrators try to meet the expectations, if the institution does not support such efforts, the outcome is compromised. I hope that educational institutions as well as teaching and administrative staff make efforts to embody the persons of principles who are knowledgeable, open-minded, caring, balanced, and reflective inquirers, thinkers, communicators, and risk-takers.
en-copyright=
kn-copyright=

en-aut-name=ChungHaeng-ja
en-aut-sei=Chung
en-aut-mei=Haeng-ja
kn-aut-name=鄭幸子
kn-aut-sei=鄭
kn-aut-mei=幸子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Okayama University
kn-affil=岡山大学
en-keyword=日米比較
kn-keyword=日米比較
en-keyword=文化人類学
kn-keyword=文化人類学
en-keyword=振り返り
kn-keyword=振り返り
en-keyword=Discovery Program for Global Learners at Okayama University
kn-keyword=Discovery Program for Global Learners at Okayama University
en-keyword=グローバル・ディスカバリー・プログラム
kn-keyword=グローバル・ディスカバリー・プログラム
en-keyword=国際バカロレア
kn-keyword=国際バカロレア
en-keyword=IB
kn-keyword=IB
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=1
article-no=
start-page=73
end-page=76
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=201802
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Spinal Extradural Arachnoid Cyst: Significance of Intrathecal Infusion after Fistula Closure
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The spinal extradural arachnoid cyst is a rare entity. Obtaining the correct diagnosis and detecting the fistula location are critical for providing effective treatment. A 41-year-old man had numbness in the soles of his feet for 2 years with accompanying gait disturbance, and a defecation disorder. Computed tomography myelography performed at another hospital revealed an epidural arachnoid cyst from Th11 to L2. He received a subarachnoid-cyst shunt at the rostral part of the cyst. However, his symptoms worsened and he was admitted to our hospital. Neuroradiological investigations revealed the correct location of the fistula at the level of Th12. We performed partial removal of the cyst wall with fistula closure via right hemilaminectomy of Th11 and 12. The complete closure of the fistula was confirmed by intrathecal infusion of artificial cerebrospinal fluid through the shunt tube. The shunt tube was removed with the sutures. The patient’s symptoms improved, although numbness remained in his bilateral heels. There has been no recurrence in 15 months since the surgery. Fistula closure may work as a balanced therapeutic strategy for spinal extradural arachnoid cyst, and intrathecal cerebrospinal fluid infusion is useful for the confirmation of complete fistula closure.
en-copyright=
kn-copyright=

en-aut-name=UmakoshiMichiari
en-aut-sei=Umakoshi
en-aut-mei=Michiari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YasuharaTakao
en-aut-sei=Yasuhara
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ToyoshimaAtsuhiko
en-aut-sei=Toyoshima
en-aut-mei=Atsuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SasadaSusumu
en-aut-sei=Sasada
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KusumegiAkira
en-aut-sei=Kusumegi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MorimotoJun
en-aut-sei=Morimoto
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KinKyohei
en-aut-sei=Kin
en-aut-mei=Kyohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TomitaYousuke
en-aut-sei=Tomita
en-aut-mei=Yousuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=fistula closure
kn-keyword=fistula closure
en-keyword=intrathecal infusion
kn-keyword=intrathecal infusion
en-keyword=microscopic surgery
kn-keyword=microscopic surgery
en-keyword=preoperative evaluation
kn-keyword=preoperative evaluation
en-keyword=recurrence
kn-keyword=recurrence
END

start-ver=1.4
cd-journal=joma
no-vol=50
cd-vols=
no-issue=6
article-no=
start-page=2024
end-page=2032
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170509
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Induction of IL-17 production from human peripheral blood CD4+ cells by asbestos exposure
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We have previously reported that chronic, recurrent and low-dose exposure to asbestos fibers causes a reduction in antitumor immunity. Investigation of natural killer (NK) cells using an in vitro cell line model and comprising in vitro activation using freshly isolated NK cells co-cultured with chrysotile fibers, as well as NK cells derived from asbestos-exposed patients with pleural plaque (PP) or malignant mesothelioma (MM), revealed decreased expression of NK cell activating receptors such as NKG2D, 2B4 and NKp46. An in vitro differentiation and clonal expansion model for CD8+ cytotoxic T lymphocytes (CTLs) showed reduced cytotoxicity with decreased levels of cytotoxic molecules such as granzyme B and perforin, as well as suppressed proliferation of CTLs. Additionally, analysis of T helper cells showed that surface CXCR3, chemokine receptor, and the productive potential of interferon (IFN)γ were reduced following asbestos exposure in an in vitro cell line model and in peripheral CD4+ cells of asbestos-exposed patients. Moreover, experiments revealed that asbestos exposure enhanced regulatory T cell (Treg) function. This study also focused on CXCR3 expression and the Th-17 cell fraction. Following activation with T-cell receptor and co-culture with various concentrations of chrysotile fibers using freshly isolated CD4+ surface CXCR3 positive and negative fractions, the intracellular expression of CXCR3, IFNγ and IL-17 remained unchanged when co-cultured with chrysotile. However, subsequent re-stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin resulted in enhanced IL-17 production and expression, particularly in CD4+ surface CXCR3 positive cells. These results indicated that the balance and polarization between Treg and Th-17 fractions play an important role with respect to the immunological effects of asbestos and the associated reduction in antitumor immunity.
en-copyright=
kn-copyright=

en-aut-name=MaedaMegumi
en-aut-sei=Maeda
en-aut-mei=Megumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ChenYing
en-aut-sei=Chen
en-aut-mei=Ying
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=LeeSuni
en-aut-sei=Lee
en-aut-mei=Suni
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=Kumagai-TakeiNaoko
en-aut-sei=Kumagai-Takei
en-aut-mei=Naoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YoshitomeKei
en-aut-sei=Yoshitome
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsuzakiHidenori
en-aut-sei=Matsuzaki
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YamamotoShoko
en-aut-sei=Yamamoto
en-aut-mei=Shoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HatayamaTamayo
en-aut-sei=Hatayama
en-aut-mei=Tamayo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IkedaMiho
en-aut-sei=Ikeda
en-aut-mei=Miho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=NishimuraYasumitsu
en-aut-sei=Nishimura
en-aut-mei=Yasumitsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OtsukiTakemi
en-aut-sei=Otsuki
en-aut-mei=Takemi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Biofunctional Chemistry, Division of Bioscience, Okayama University Graduate School of Natural Science and Technology
kn-affil=

affil-num=2
en-affil= Department of Hygiene, Kawasaki Medical School
kn-affil=

affil-num=3
en-affil= Department of Hygiene, Kawasaki Medical School
kn-affil=

affil-num=4
en-affil= Department of Hygiene, Kawasaki Medical School
kn-affil=

affil-num=5
en-affil= Department of Hygiene, Kawasaki Medical School
kn-affil=

affil-num=6
en-affil= Department of Hygiene, Kawasaki Medical School
kn-affil=

affil-num=7
en-affil= Department of Hygiene, Kawasaki Medical School
kn-affil=

affil-num=8
en-affil= Department of Hygiene, Kawasaki Medical School
kn-affil=

affil-num=9
en-affil= Department of Hygiene, Kawasaki Medical School
kn-affil=

affil-num=10
en-affil= Department of Hygiene, Kawasaki Medical School
kn-affil=

affil-num=11
en-affil= Department of Hygiene, Kawasaki Medical School
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=NASH及びNASH関連肝臓癌と血清酸化ストレス/抗酸化ストレスバランス障害の検討
kn-title=The Serum Oxidative/Anti-oxidative Stress Balance Becomes Dysregulated in Patients with Non-alcoholic Steatohepatitis Associated with Hepatocellular Carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ShimomuraYasuyuki
en-aut-sei=Shimomura
en-aut-mei=Yasuyuki
kn-aut-name=下村泰之
kn-aut-sei=下村
kn-aut-mei=泰之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=129
cd-vols=
no-issue=1
article-no=
start-page=9
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170403
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Does hydrogen-rich water really work?
kn-title=水素水は怪しい水でしょうか？
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=中尾篤典
kn-aut-sei=中尾
kn-aut-mei=篤典
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　救急医学
en-keyword=水素水
kn-keyword=水素水
en-keyword=抗酸化作用
kn-keyword=抗酸化作用
en-keyword=抗炎症作用
kn-keyword=抗炎症作用
en-keyword=臨床応用
kn-keyword=臨床応用
en-keyword=疑似科学
kn-keyword=疑似科学
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=11
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170116
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Changing Roles of Traditional Small Urban Green Spaces (Telajakan) in Bali, Indonesia
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Bali Island, Indonesia is undergoing rapid land use changes due to heavy development pressure and its fast growing urban population. One such urbanization phenomenon is the shrinkage, deterioration, and disappearance of traditional small urban green spaces in Denpasar, Bali. Focusing on telajakan, a strip of traditional green space between the wall of a housing compound and a ditch/pedestrian path in a roadside, the study aims 1) to investigate and document the changes that are occurring with regards to telajakan and 2) to assess the functions (roles) of telajakan in Denpasar. The research methods include vegetation assessment at a lot scale and in-depth homeowner and village leader interviews with the help of local experts. The results show that telajakan space is often paved over to give way to more front space for the property owner and to ease maintenance. It is also minimized or destroyed as the owner builds a more “western” style house. Traditionally telajakan has multiple functions such as provision of plant and flower materials for Balinese daily rituals, regu-lation of stormwater from the property, and offering semi-public space for street vendors and neighbours. However, the results show that: diversity of planted species is decreasing; only a couple of functions such as aesthetics and economics are strongly favored; and the semi-public nature of telajakan is being lost. Since telajakan is as much traditional green open space as part of the aesthetics of the Balinese architecture, its loss, minimization, and degradation lead to the loss of Balinese culture and identity. On the other hand, new meaning is given to telajakan’s functions such as neighborhood beautification and exhibition of the owner’s pride in the modern context. Therefore, policy recommendations to conserve telajakan in the changing urban fabric need to balance these changing needs of telajakan for its use and conservation of traditional rituals and culture of Bali.
en-copyright=
kn-copyright=

en-aut-name=KatoSadahisa
en-aut-sei=Kato
en-aut-mei=Sadahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HishiyamaKosuke
en-aut-sei=Hishiyama
en-aut-mei=Kosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Anak Agung Ketut Darmadi
en-aut-sei=Anak Agung Ketut Darmadi
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=Dewa Ngurah Suprapta
en-aut-sei=Dewa Ngurah Suprapta
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Institute for Global Human Resource Development, Okayama University
kn-affil=

affil-num=2
en-affil=Faculty of Applied Sociology, Kindai University
kn-affil=

affil-num=3
en-affil=Laboratory of Biopesticide, Faculty of Agriculture, Udayana University
kn-affil=

affil-num=4
en-affil=Laboratory of Biopesticide, Faculty of Agriculture, Udayana University
kn-affil=
en-keyword=Telajakan
kn-keyword=Telajakan
en-keyword=Bali
kn-keyword=Bali
en-keyword=Urban Green Spaces
kn-keyword=Urban Green Spaces
END

start-ver=1.4
cd-journal=joma
no-vol=59
cd-vols=
no-issue=1
article-no=
start-page=117
end-page=130
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201701
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A note on balance equations for doubly periodic minimal surfaces
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Most known examples of doubly periodic minimal surfaces in R<sup>3</sup> with parallel ends limit as a foliation of R<sup>3</sup> by horizontal noded planes, with the location of the nodes satisfying a set of balance equations. Conversely, for each set of points providing a balanced configuration, there is a corresponding three-parameter family of doubly periodic minimal surfaces. In this note we derive a differential equation that is equivalent to the balance equations for doubly periodic minimal surfaces. This allows for the generation of many more solutions to the balance equations, enabling the construction of increasingly complicated surfaces.
en-copyright=
kn-copyright=

en-aut-name=ConnorPeter
en-aut-sei=Connor
en-aut-mei=Peter
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Mathematical Sciences, Indiana University South Bend
kn-affil=
en-keyword=minimal surfaces
kn-keyword=minimal surfaces
en-keyword=doubly periodic
kn-keyword=doubly periodic
en-keyword=balance equations
kn-keyword=balance equations
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=高齢者の起立動作における前後バランス能力の評価
kn-title=Evaluation of the balance capabilities of elderly people rising in the longitudinal direction
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HiraiHideo
en-aut-sei=Hirai
en-aut-mei=Hideo
kn-aut-name=平井秀雄
kn-aut-sei=平井
kn-aut-mei=秀雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20151231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=肺高血圧を伴う肝硬変患者において酸化ストレス・抗酸化力のバランスは障害されている：症例対照研究
kn-title=Serum Oxidative/anti-oxidative Stress Balance Is Dysregulated in Potentially Pulmonary Hypertensive Patients with Liver Cirrhosis : A Case Control Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TeraoMasako
en-aut-sei=Terao
en-aut-mei=Masako
kn-aut-name=寺尾正子
kn-aut-sei=寺尾
kn-aut-mei=正子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=
article-no=
start-page=1
end-page=5
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Survey on the undernourished university students who tend to lack breakfast ; a proposal for a novel viewpoint for the improvement
kn-title=大学生の朝食欠食習慣の統計解析と改善への新指針
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study investigated the current status and causes underneath the life of university students who tend to lack breakfast at a relatively high frequency, and statistical analysis on consequences leading to such lack of well-nourished eating habitat in their university life. In October 2014, self-assessed questionnaires were administered to over 150 faculty students. It contained questions about breakfast habits, time allowance for the morning class, and lunchtime setting in their high school timetable. Breakfast states were clearly separated in three groups : 68% of students regularly have breakfast throughout the weekdays, 21% students skipping the breakfast occasionally, and 11% student no habit for breakfast at all. The survey on the high school lives revealed that 70% students used to have lunch 30 min later than the lunchtime set in the university timetable, 7% of them had the lunch time even more than 1 h later. Lunchtime varies among high schools, and statistical significance was revealed (p<0.01) that schools with higher deviation scores tend have late lunch beyond 12: 30. Accordingly, university students were given directions to prepare for the timetable reform on postulation of having lunch time over one o’clock. After continuous survey on the breakfast habits during the second semester, more than 90% of students established the habit of breakfast regularly in their university lives with the improved consciousness toward well-balanced healthy breakfast contents for their higher level of education quality.
en-copyright=
kn-copyright=

en-aut-name=TamuraT.
en-aut-sei=Tamura
en-aut-mei=T.
kn-aut-name=田村隆
kn-aut-sei=田村
kn-aut-mei=隆
aut-affil-num=1
ORCID=

en-aut-name=IbiT.
en-aut-sei=Ibi
en-aut-mei=T.
kn-aut-name=揖斐隆之
kn-aut-sei=揖斐
kn-aut-mei=隆之
aut-affil-num=2
ORCID=

en-aut-name=InagakiK.
en-aut-sei=Inagaki
en-aut-mei=K.
kn-aut-name=稲垣賢二
kn-aut-sei=稲垣
kn-aut-mei=賢二
aut-affil-num=3
ORCID=

en-aut-name=KuboY.
en-aut-sei=Kubo
en-aut-mei=Y.
kn-aut-name=久保康隆
kn-aut-sei=久保
kn-aut-mei=康隆
aut-affil-num=4
ORCID=

en-aut-name=OkudaK.
en-aut-sei=Okuda
en-aut-mei=K.
kn-aut-name=奥田潔
kn-aut-sei=奥田
kn-aut-mei=潔
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学教務FD 委員会

affil-num=2
en-affil=
kn-affil=岡山大学教務FD 委員会

affil-num=3
en-affil=
kn-affil=岡山大学教務FD 委員会

affil-num=4
en-affil=
kn-affil=岡山大学教務FD 委員会

affil-num=5
en-affil=
kn-affil=岡山大学教務FD 委員会
en-keyword=Undernourished students
kn-keyword=Undernourished students
en-keyword=breakfast
kn-keyword=breakfast
en-keyword=lunchtime
kn-keyword=lunchtime
en-keyword=statistical significance
kn-keyword=statistical significance
END

start-ver=1.4
cd-journal=joma
no-vol=31
cd-vols=
no-issue=
article-no=
start-page=50
end-page=54
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=201504
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The practice of "animal experimental science" education that broaden student perspectives
kn-title=視野の拡大を取り入れた「動物実験学」教育の試み
en-subtitle=
kn-subtitle=
en-abstract=When they first enroll, most university students have a negative view of animal experiments. To provide a more accurate and balanced understanding, we have introduced "animal experimental science" education that aims to broaden perspectives. In addition to conventional animal experiments in medicine and biotechnology, we have also introduced the concept of experimentation in the field of animal nursing, in which the role of the companion animal is studied. In the lower grades, students have little information and tend to assume that all animal experiments are cruel.
They are therefore very critical of animal experiments. In the higher grades, students take part in animal experiments. By appreciating the need for such experiments, our students became less critical. As graduation thesis students, many students choose to undertake animal experiments, if a scientific challenge requires it. Introducing the concepts of “laboratory animals” and “animal experiments” at the right educational stage leads students to a better understanding of animal experimentation. Through this process, the students’ reluctant acceptance can be changed to acceptance with a positive attitude.
kn-abstract=入学時に動物実験に対し悪いイメージを持っている学生は少なくない。倉敷芸術科学大学生命科学部動物生命科学科では動物実験に対する正しい理解のため、医学およびバイオ分野における従来の動物実験の考え方のみならず、家庭動物を学びの対象とする動物看護分野における動物実験の考え方を取り入れることで、視点の拡大を目指す動物実験学を導入している。動物実験についての情報が少ない低学年では、「動物実験は残酷である」という部分に視点が集中し批判的な意見をもっている。しかしながら、学年が上がっていく過程で自身が動物実験を実施し、その必要性を実感する経験を繰り返すことで、動物実験を単に批判することはなくなっていく。4 年生では卒業研究における課題に科学的アプローチするために動物実験が必要な場合、多くの学生が動物実験の実施を前向きに選択するようにまでなる。学生の学びの対象に即した実験動物や動物実験の定義を教育に導入することで、動物実験への正しい理解へ繋がり、消極的容認が容認や肯定的態度へと変化していくと考えられる。
en-copyright=
kn-copyright=

en-aut-name=FurumotoKayo
en-aut-sei=Furumoto
en-aut-mei=Kayo
kn-aut-name=古本佳代
kn-aut-sei=古本
kn-aut-mei=佳代
aut-affil-num=1
ORCID=

en-aut-name=FurukawaToshinori
en-aut-sei=Furukawa
en-aut-mei=Toshinori
kn-aut-name=古川敏紀
kn-aut-sei=古川
kn-aut-mei=敏紀
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=倉敷芸術科学大学 生命科学部 動物生命科学科

affil-num=2
en-affil=
kn-affil=倉敷芸術科学大学 生命科学部 動物生命科学科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Enhancing care homes with assistive video technology for distributed caregiving
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Dementia care is becoming increasingly important in Japan as the elderly population grows. Care homes are designed so that caregivers can easily observe and subsequently respond to the needs of people with dementia. However, the layout of care homes can become overly restrictive for residents, for example, by not providing intermediate spaces where people can spontaneously interact and initiate conversations. We present a case study that explores the implementation of video monitoring in two purpose-built care homes in which we were asked to help overcome the blind spots presented by the layout. We collected data both before and after the implementation of the video monitoring in order to understand its effect. The balance between people’s sense of security and the concerns about loss of privacy through video monitoring is well established. However, we found that video monitoring had a beneficial effect on both the caregivers and the residents if implemented sensitively. Furthermore, the implementation of video monitoring could support the design of more beneficial care home layouts. In conclusion, we propose that the sensitive implementation of video monitoring be considered alongside design of the physical layout of care homes.
en-copyright=
kn-copyright=

en-aut-name=SugiharaTaro
en-aut-sei=Sugihara
en-aut-mei=Taro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FujinamiTsutomu
en-aut-sei=Fujinami
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=JonesRachel
en-aut-sei=Jones
en-aut-mei=Rachel
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KadowakiKozo
en-aut-sei=Kadowaki
en-aut-mei=Kozo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AndoMasaya
en-aut-sei=Ando
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=2
en-affil=
kn-affil=School of Knowledge Science, Japan Advanced Institute of Science and Technology

affil-num=3
en-affil=
kn-affil=Instrata Limited

affil-num=4
en-affil=
kn-affil=School of Science and Technology, Meiji University

affil-num=5
en-affil=
kn-affil=Faculty of Engineering, Chiba Institute of Technology
en-keyword=People with dementia
kn-keyword=People with dementia
en-keyword=Caregivers
kn-keyword=Caregivers
en-keyword=Care homes
kn-keyword=Care homes
en-keyword=Spatial layouts
kn-keyword=Spatial layouts
en-keyword=Video monitoring
kn-keyword=Video monitoring
en-keyword=Qualitative research
kn-keyword=Qualitative research
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=5
article-no=
start-page=1010
end-page=1017
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201105
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Therapy for hyperthermia-induced seizures in Scn1a mutant rats
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose: Mutations in the SCN1A gene, which encodes the alpha 1 subunit of voltage-gated sodium channels, cause generalized epilepsy with febrile seizures plus (GEFS+) and severe myoclonic epilepsy of infancy (SMEI). N1417H-Scn1a mutant rats are considered to be an animal model of human FS+ or GEFS+. To assess the pharmacologic validity of this model, we compared the efficacies of eight different antiepileptic drugs (AEDs) for the treatment of hyperthermia-induced seizures using N1417H-Scn1a mutant rats. 

Methods: AEDs used in this study included valproate, carbamazepine (CBZ), phenobarbital, gabapentin, acetazolamide, diazepam (DZP), topiramate, and potassium bromide (KBr). The effects of these AEDs were evaluated using the hot water model, which is a model of experimental FS. Five-week-old rats were pretreated with each AED and immersed in water at 45 degrees C to induce hyperthermia-induced seizures. The seizure manifestations and video-electroencephalographic recordings were evaluated. Furthermore, the effects of each AED on motor coordination and balance were assessed using the balance-beam test. 

Key Findings: KBr significantly reduced seizure durations, and its anticonvulsant effects were comparable to those of DZP. On the other hand, CBZ decreased the seizure threshold. In addition, DZP and not KBr showed significant impairment in motor coordination and balance. 

Significance: DZP and KBr showed potent inhibitory effects against hyperthermia-induced seizures in the Scn1a mutant rats, whereas CBZ exhibited adverse effects. These responses to hyperthermia-induced seizures were similar to those in patients with GEFS+ and SMEI. N1417H-Scn1a mutant rats may, therefore, be useful for testing the efficacy of new AEDs against FS in GEFS+ and SMEI patients.
en-copyright=
kn-copyright=

en-aut-name=HayashiKeiichiro
en-aut-sei=Hayashi
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UeshimaSatoshi
en-aut-sei=Ueshima
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OuchidaMamoru
en-aut-sei=Ouchida
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MashimoTomoji
en-aut-sei=Mashimo
en-aut-mei=Tomoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NishikiTeiichi
en-aut-sei=Nishiki
en-aut-mei=Teiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SerikawaTadao
en-aut-sei=Serikawa
en-aut-mei=Tadao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MatsuiHideki
en-aut-sei=Matsui
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OhmoriIori
en-aut-sei=Ohmori
en-aut-mei=Iori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Physiol

affil-num=2
en-affil=
kn-affil=Okayama Univ Hosp, Dept Pharm

affil-num=3
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Genet

affil-num=4
en-affil=
kn-affil=Kyoto Univ, Grad Sch Med, Inst Lab Anim

affil-num=5
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Physiol

affil-num=6
en-affil=
kn-affil=Okayama Univ Hosp, Dept Pharm

affil-num=7
en-affil=
kn-affil=Kyoto Univ, Grad Sch Med, Inst Lab Anim

affil-num=8
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Physiol

affil-num=9
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Physiol
en-keyword=Febrile seizure
kn-keyword=Febrile seizure
en-keyword=Animal models
kn-keyword=Animal models
en-keyword=Scn1a gene
kn-keyword=Scn1a gene
en-keyword=Generalized epilepsy with febrile seizures plus
kn-keyword=Generalized epilepsy with febrile seizures plus
en-keyword=Severe myoclonic epilepsy of infancy
kn-keyword=Severe myoclonic epilepsy of infancy
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=2
article-no=
start-page=159
end-page=163
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Drug interaction (30. combination with therapeutic drugs for chronic pain)
kn-title=薬物相互作用 (30―慢性疼痛治療薬の相互作用）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OgawaAtsushi
en-aut-sei=Ogawa
en-aut-mei=Atsushi
kn-aut-name=小川敦
kn-aut-sei=小川
kn-aut-mei=敦
aut-affil-num=1
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=北村佳久
kn-aut-sei=北村
kn-aut-mei=佳久
aut-affil-num=2
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=千堂年昭
kn-aut-sei=千堂
kn-aut-mei=年昭
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院　薬剤部

affil-num=2
en-affil=
kn-affil=岡山大学病院　薬剤部

affil-num=3
en-affil=
kn-affil=岡山大学病院　薬剤部
END

start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=10
article-no=
start-page=1078
end-page=1092
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Serum oxidative-anti-oxidative stress balance is dysregulated in patients with hepatitis C virus-related hepatocellular carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Aim
Oxidative stress is associated with progression of chronic liver disease (CLD). This association is best established in chronic hepatitis C. However, the anti-oxidative state is not well characterized. The objective of the present study was to investigate the balance of oxidative and anti-oxidative stress in CLD patients.

Methods
We recruited a study population of 208 patients, including healthy volunteers (HV; n = 15), patients with hepatitis B virus (HBV)-related CLD without or with hepatocellular carcinoma (HBV-non-HCC, n = 25, and HBV-HCC, n = 50, respectively), and patients with hepatitis C virus (HCV)-related CLD without or with HCC (HCV-non-HCC, n = 49, and HCV-HCC, n = 69, respectively). Serum levels of reactive oxygen metabolites (ROM) and anti-oxidative markers (OXY-adsorbent test; OXY) were determined, and the balance of these values was used as the oxidative index. Correlations among ROM, OXY, oxidative index and clinical characteristics were investigated.

Results
Patients with CLD exhibited elevated ROM and oxidative index compared to HV. Among patients with CLD, HCV positive status correlated with increased ROM. In CLD, HCV-HCC patients exhibited the highest ROM levels. Among HCV-related CLD patients, lower OXY correlated with HCC positive status, but was recovered by eradication of HCC. In HCV-HCC, lower OXY correlated with high PT-INR.

Conclusion
HCV positive CLD patients displayed higher oxidative stress and HCV-HCC patients displayed lower anti-oxidative state. Anti-oxidative state depression was associated with liver reservoir-related data in HCV-HCC and could be reversed with HCC eradication.
en-copyright=
kn-copyright=

en-aut-name=NishimuraMamoru
en-aut-sei=Nishimura
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakakiAkinobu
en-aut-sei=Takaki
en-aut-mei=Akinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TamakiNaofumi
en-aut-sei=Tamaki
en-aut-mei=Naofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MaruyamaTakayuki
en-aut-sei=Maruyama
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OnishiHideki
en-aut-sei=Onishi
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KobayashiSayo
en-aut-sei=Kobayashi
en-aut-mei=Sayo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NousoKazuhiro
en-aut-sei=Nouso
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YasunakaTetsuya
en-aut-sei=Yasunaka
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KoikeKazuko
en-aut-sei=Koike
en-aut-mei=Kazuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HagiharaHiroaki
en-aut-sei=Hagihara
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KuwakiKenji
en-aut-sei=Kuwaki
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=NakamuraShinichiro
en-aut-sei=Nakamura
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=IkedaFusao
en-aut-sei=Ikeda
en-aut-mei=Fusao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=IwasakiYoshiaki
en-aut-sei=Iwasaki
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=TomofujiTakaaki
en-aut-sei=Tomofuji
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=MoritaManabu
en-aut-sei=Morita
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=YamamotoKazuhide
en-aut-sei=Yamamoto
en-aut-mei=Kazuhide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=3
en-affil=
kn-affil=Department of Preventive Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School

affil-num=4
en-affil=
kn-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=5
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=6
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=7
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=8
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=9
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=10
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=11
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=12
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=13
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=14
en-affil=
kn-affil=Health Service Center, Okayama University

affil-num=15
en-affil=
kn-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=16
en-affil=
kn-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=17
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
en-keyword=anti-oxidant
kn-keyword=anti-oxidant
en-keyword=chronic hepatitis C
kn-keyword=chronic hepatitis C
en-keyword=hepatocellular carcinoma
kn-keyword=hepatocellular carcinoma
en-keyword=oxidative stress
kn-keyword=oxidative stress
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=C型肝炎関連肝癌患者において酸化ストレス・抗酸化力のバランスは障害されている
kn-title=Serum oxidative-anti-oxidative stress balance is dysregulated in patients with hepatitis C virus-related hepatocellular carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NishimuraMamoru
en-aut-sei=Nishimura
en-aut-mei=Mamoru
kn-aut-name=西村守
kn-aut-sei=西村
kn-aut-mei=守
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=2
article-no=
start-page=152
end-page=174
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Structural problems of regional development practices in terms of sectoral GDP per capita in Turkey
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In integration of Turkey to the EU,the scope of regional programs has been transformed to reach
the basic regional socio-economic standards of the Union. In this way, new cooperative regional
programs have been applied in Turkey by the EU and Turkey. Therefore, some regional programs
in Nomenclature of Territorial Units for Statistics（NUTS）level-2 regions have been examined in
this study. In this point, the data of regional GDP per capita by sectors has been used to analyse
sectoral disparities in terms of Gini index. To discuss and evaluate the future of the programs on
regional disparities, related sector parameters of GDP per capita have been calculated by regression analysis through（balanced）panel data. The findings showed that there is a remarkable sectoral disparity among program regions, and the sector priorities of the programs are not sufficient
to bring any long-term solution for the regional disparities. Finally, Turkey from regional and/or
multiregional perspectives needs to reconsider the regional programs for decreasing the disparities
as much as development ofthe regions.
en-copyright=
kn-copyright=

en-aut-name=DincsoyEnver Erdinc
en-aut-sei=Dincsoy
en-aut-mei=Enver Erdinc
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IchiminamiFumikazu
en-aut-sei=Ichiminami
en-aut-mei=Fumikazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University, Graduate School of Natural Science and Technology

affil-num=2
en-affil=
kn-affil=Okayama University, Graduate School of Environmental Science and Technology
en-keyword=Regional program
kn-keyword=Regional program
en-keyword=Sectoral GDP per capita
kn-keyword=Sectoral GDP per capita
en-keyword=Gini index
kn-keyword=Gini index
en-keyword=the EU
kn-keyword=the EU
en-keyword=Turkey
kn-keyword=Turkey
END

start-ver=1.4
cd-journal=joma
no-vol=50
cd-vols=
no-issue=3
article-no=
start-page=139
end-page=149
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1964
dt-pub=196410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A heat balance observation on a snow field in Fukui Pref. in the ablation period of 1963.
kn-title=融雪期における積雪面上の熱収支の一観測例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SeoT.
en-aut-sei=Seo
en-aut-mei=T.
kn-aut-name=瀬尾琢郎
kn-aut-sei=瀬尾
kn-aut-mei=琢郎
aut-affil-num=1
ORCID=

en-aut-name=YamaguchiN.
en-aut-sei=Yamaguchi
en-aut-mei=N.
kn-aut-name=山口信之
kn-aut-sei=山口
kn-aut-mei=信之
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=2
article-no=
start-page=79
end-page=92
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1974
dt-pub=1974
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ATMOSPHERIC FLUX OF CARBON DIOXIDE OVER PADDY FIELDS ESTIMATED BY HEAT BALANCE APPROACH*
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SeoTakuro
en-aut-sei=Seo
en-aut-mei=Takuro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhtakiEiji
en-aut-sei=Ohtaki
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=1
article-no=
start-page=13
end-page=21
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1965
dt-pub=1965
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=AN OBSERVATION OF HEAT BALANCE ON A SNOW FIELD AT THE TIME OF ABLATION IN 1963
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SeoTakuro
en-aut-sei=Seo
en-aut-mei=Takuro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamaguchiNobuyuki
en-aut-sei=Yamaguchi
en-aut-mei=Nobuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=44
cd-vols=
no-issue=4
article-no=
start-page=21
end-page=40
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Survey of Studies in Hindrance(Resistance) to Organizational Change: Focus on its Factor, Mechanism, Elimination. (the second half)
kn-title=組織変革における阻害に関する既存研究の概観（後） 　　～要因・メカニズム・除去を対象にして～
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Organizational change is important topics in organizational behavior. This paper aims to survey of studies in hindrance(resistance) to organizational change. Especially, we focus on its factor, mechanism, and elimination. And so, we suevey previous studies from viewpoint of ①macro organizational theory＇s arguments(Ma. O), ②micro organizational theory＇s arguments(Mi. O), ③social psychology theory＇s arguments(S. P), ④consultant's suggestion(C. S).
This paper's important points are as follows: 
①factor are various: organizational inertia, action, information＇ flow(Ma. O), loss, stress, trust, recognition, learning(Mi. O), resistance, worry, self-defense(S. P), failure and behavior(8 factors), restrictive functions in equilibrium(10 problems), barrier(C. S). ②Mechanism are various: organizational inertia, action(Ma. O), loss and compusion, recognition(schema, conflict), organizational culture change(Mi. O), driving force and resistance force, influence and balance(S. P). damage, crisis andadherence(C. S). ③Elimination: organizational inertia, adaptation and balance, restraint, adjustment(Ma. O), participation, reward system, vision(Mi. O), participation, job design, taking turns, persuasion(S. P), paticipation, commitment, many eliminated methods(C. S).
Addtionaly, our problems are as follows;
①significance of discussion and ②promotion factor in organizational change. And ③rationality, ④measuring method, ⑤practicing to management in organizational change.
en-copyright=
kn-copyright=

en-aut-name=MatsudaYoichi
en-aut-sei=Matsuda
en-aut-mei=Yoichi
kn-aut-name=松田陽一
kn-aut-sei=松田
kn-aut-mei=陽一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=44
cd-vols=
no-issue=2
article-no=
start-page=1
end-page=23
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20121001
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Political-Economic Situation and the Financial Condition of Local Governments in Poland
kn-title=ポーランド経済の成長と地方自治政策および地方自治体の財政状況
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper conducts a critical analysis on the political-economic situation of Poland and the current financial condition of the Polish local governments.
Poland was the only country in the EU that avoided recession in 2009, i.e. just after the financial crisis it the world in 2008. While a number of studies suggest that the strong exports and individual consumption expenditures have been supporting the economy, they tend to miss the crucial fact that local government finance in the country is relatively well-balanced, and it became one of the factors of the economic stability. Aiming at examining such curious steadiness of the Polish local governments, this paper first focuses on the political and economic situation in Poland to understand the background of the financial condition of the local governments. Secondly, the system of local autonomy and its changes will be reviewed. Thirdly, the paper outlines the current political situation of the country, particularly the outcome of the general election held in 2012. Different regional strategies of the major political parties will be analyzed as well. Finally, the condition of local government finance will be examined to clarify their problems and challenges.
From the analysis of this paper, the following points will be elucidated:
(1) The solid economic performance has been maintained in Poland even after the global economic crisis.
(2) The disparity of economic growth by prefecture and the disparity of the domestic product per capita by prefecture both show observable trend of its increase.
(3) There is a big difference in the regional policy between the two major political parties in the country. The ruling party, the Civic Platform (Platforma Obywatelska; PO), bases its policy on the EU cohesion fund and adopts the economic growth model, in which the economies of metropolises are the engine to lead the country’s economy. On the other hand, the main opposition party, Law and Justice (Prawo i Sprawiedliwość; PiS), sets the liquidation of domestic disparities based on the “Polish” policies as its main goal.
(4) The local government system of Poland is characterized by the great authority of commune (gmina) and the securing of tax revenue by the state. This model has been ensuring financial stability of the local government.
(5) Many state-owned real estates have been changed to come under local government ownership during the period of systemic transformation. The incomes from the real estates and gains upon their sale have been contributing to the stability of local government finance.
(6) Local governments have been one of the factors of Poland’s stable growth. However, many local governments recently started to fall into deficit. The causes of the deficit are as follows: a slowdown in tax revenues due to the recession; the falling real estate prices, the rising prices of construction materials for public works; the rising energy prices; and natural disasters that occur frequently in recent years.
(7) The reduction policy of the state budget, directly bound up with the tighter condition of local government finance, as well as the decrease of financial supports from the EU Cohesion Fund and its related cuts in budgets for public works, has a negative impact on the local economy. They consequently affect the growth of the Polish economy to cause its slowing down.
en-copyright=
kn-copyright=

en-aut-name=TaguchiMasahiro
en-aut-sei=Taguchi
en-aut-mei=Masahiro
kn-aut-name=田口雅弘
kn-aut-sei=田口
kn-aut-mei=雅弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=22
article-no=
start-page=3306
end-page=3309
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=2009
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Fabricating small-scale, curved, polymeric structures with convex and concave menisci through interfacial free energy equilibrium
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Polymeric curved structures are widely used in imaging systems including optical fibers and microfluidic channels. Here, we demonstrate that small-scale, poly(dimethylsiloxane) (PDMS)-based, curved structures can be fabricated through controlling interfacial free energy equilibrium. Resultant structures have a smooth, symmetric, curved surface, and may be convex or concave in form based on surface tension balance. Their curvatures are controlled by surface characteristics (i.e., hydrophobicity and hydrophilicity) of the molds and semi-liquid PDMS. In addition, these structures are shown to be biocompatible for cell culture. Our system provides a simple, efficient and economical method for generating integrateable optical components without costly fabrication facilities.
en-copyright=
kn-copyright=

en-aut-name=ChengChao-Min
en-aut-sei=Cheng
en-aut-mei=Chao-Min
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsuuraKoji
en-aut-sei=Matsuura
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WangI-Jan
en-aut-sei=Wang
en-aut-mei=I-Jan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KurodaYuka
en-aut-sei=Kuroda
en-aut-mei=Yuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=LeDucPhilip R.
en-aut-sei=LeDuc
en-aut-mei=Philip R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NaruseKeiji
en-aut-sei=Naruse
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=Departments of Mechanical and Biomedical Engineering and Biological Sciences, Carnegie Mellon University

affil-num=2
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University

affil-num=3
en-affil=
kn-affil=Departments of Mechanical and Biomedical Engineering and Biological Sciences, Carnegie Mellon University

affil-num=4
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University

affil-num=5
en-affil=
kn-affil=Departments of Mechanical and Biomedical Engineering and Biological Sciences, Carnegie Mellon University

affil-num=6
en-affil=
kn-affil=Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=2
article-no=
start-page=101
end-page=104
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A constitutively active calcineurin encoded by an intron-containing mRNA is involved in hair cycle regulation
kn-title=恒常活性型カルシニューリンによる毛周期制御機構―新しい機構に基づく発毛促進ペプチドの開発―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FujimuraAtsushi
en-aut-sei=Fujimura
en-aut-mei=Atsushi
kn-aut-name=藤村篤史
kn-aut-sei=藤村
kn-aut-mei=篤史
aut-affil-num=1
ORCID=

en-aut-name=TomizawaKazuhito
en-aut-sei=Tomizawa
en-aut-mei=Kazuhito
kn-aut-name=富澤一仁
kn-aut-sei=富澤
kn-aut-mei=一仁
aut-affil-num=2
ORCID=

en-aut-name=MatsuiHideki
en-aut-sei=Matsui
en-aut-mei=Hideki
kn-aut-name=松井秀樹
kn-aut-sei=松井
kn-aut-mei=秀樹
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学

affil-num=2
en-affil=
kn-affil=熊本大学大学院生命科学研究部　分子生理学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学
en-keyword=calcineurin/NFAT
kn-keyword=calcineurin/NFAT
en-keyword=alternative splicing
kn-keyword=alternative splicing
en-keyword=calcium sensitivity
kn-keyword=calcium sensitivity
en-keyword=hair cycle
kn-keyword=hair cycle
en-keyword=cyclin G2
kn-keyword=cyclin G2
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=3
article-no=
start-page=231
end-page=237
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Early Rehabilitation with Weight-bearing Standing-shaking-board Exercise in Combination with Electrical Muscle Stimulation after Anterior Cruciate Ligament Reconstruction
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The objective of early rehabilitation after anterior cruciate ligament (ACL) reconstruction is to increase the muscle strength of the lower extremities. Closed kinetic chain (CKC) exercise induces co-contraction of the agonist and antagonist muscles. The purpose of this study was to compare the postoperative muscle strength/mass of subjects who performed our new CKC exercise (new rehabilitation
group:group N) from week 4, and subjects who received traditional rehabilitation alone (traditional
rehabilitation group:group T). The subjects stood on the device and maintained balance. Then, low-frequency stimulation waves were applied to 2 points each in the anterior and posterior region of the injured thigh 3 times a week for 3 months. Measurement of muscle strength was performed 4 times (before the start, and then once a month). Muscle mass was evaluated in CT images of the extensor and flexor muscles of 10 knees (10 subjects) in each group. The injured legs of group N showed significant improvement after one month compared to group T. The cross-sectional area of the extensor muscles of the injured legs tended to a show a greater increase at 3 months in group N. This rehabilitation method makes it possible to contract fast-twitch muscles, which may be a useful for improving extensor muscle strength after ACL reconstruction.
en-copyright=
kn-copyright=

en-aut-name=TakahashiKingo
en-aut-sei=Takahashi
en-aut-mei=Kingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HayashiMasamichi
en-aut-sei=Hayashi
en-aut-mei=Masamichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujiiToshihiro
en-aut-sei=Fujii
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KawamuraKenji
en-aut-sei=Kawamura
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Orthopedic Surgery, Ako Central Hospital

affil-num=2
en-affil=
kn-affil=Okayama Saiseikai General Hospital

affil-num=3
en-affil=
kn-affil=Okayama Saiseikai General Hospital

affil-num=4
en-affil=
kn-affil=Graduate School of Health Science, Kibi International University

affil-num=5
en-affil=
kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine
en-keyword=anterior cruciate ligament reconstruction
kn-keyword=anterior cruciate ligament reconstruction
en-keyword=closed kinetic chain
kn-keyword=closed kinetic chain
en-keyword=electrical muscle stimulation
kn-keyword=electrical muscle stimulation
en-keyword=standing-shaking-board exercise
kn-keyword=standing-shaking-board exercise
END

start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=3
article-no=
start-page=1
end-page=13
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20111201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A study on the conflict and intertwine of the accounting standards and the tax law in asset losses
kn-title=資産の下向的評価損失を巡る会計と税務の対立と交錯 : 債務（損失）確定主義と公正価値会計との相克
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper first refers to the key concept of recognition of asset losses under the corporate tax law. The tax law basically restricts the loss deduction and imposes requirements of "settlements" with a fact of physical or
monetary damage for the special loss deduction unless potential nonrecognized losses may be deducted under the accounting standards from the viewpoint of disclosure for asset fair values. This loss deduction rule is derived from the foreseeability and legal stability in calculation of taxable income. This paper secondly explains the content and legislative context of the recent amendments in the depreciation system and allowance expenses. Some allowance systems has been repealed in order to enlarge the tax base and
increase the tax revenue, however, the accelerated depreciation, newly introduced system in the recent corporate tax reform, brought a broad accrual expense, where it caused an opposite result to the tax base. I would rather
mention the background of the past tax reforms and suggest the range of estimated accrual expenses should be more broadened. Finally, this paper would clarify the contemporary signification in the loss deduction rule. ASBJ has issued the cumulative accounting standards for the global convergence, and is now required the final decision for the IFRS adoption. It would likely be said that harmonization between the accounting and tax enforcement would
be continuously pursed through this convergence process. The loss deduction rule would have a vital role in the fair value measurement in tax accounting, where tax income and each tax item on a balance sheet are measured by an index with high accuracy and legal settlement.
en-copyright=
kn-copyright=

en-aut-name=KobayashiHiroaki
en-aut-sei=Kobayashi
en-aut-mei=Hiroaki
kn-aut-name=小林裕明
kn-aut-sei=小林
kn-aut-mei=裕明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=123
cd-vols=
no-issue=3
article-no=
start-page=185
end-page=189
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20111201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Anti-HMGB1 mAb protects the blood-brain barrier from ischemia-induced disruption in rats
kn-title=ラット中大脳動脈閉塞・再灌流モデルにおける抗HMGB1単クローン抗体の血液―脳関門の保護効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ZhangJiyong
en-aut-sei=Zhang
en-aut-mei=Jiyong
kn-aut-name=張継勇
kn-aut-sei=張
kn-aut-mei=継勇
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　薬理学
en-keyword=脳梗塞
kn-keyword=脳梗塞
en-keyword=血液脳関門
kn-keyword=血液脳関門
en-keyword=炎症
kn-keyword=炎症
en-keyword=HMGB1
kn-keyword=HMGB1
en-keyword=抗体医薬
kn-keyword=抗体医薬
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=778
article-no=
start-page=2323
end-page=2335
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201106
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Analysis and Control of Model to Develop Support Device Using Biarticular Muscle with Rubber Artificial Muscles
kn-title=二関節筋型ゴム人工筋を用いた支援装置モデルの解析と制御
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper, the authors aim at developing a wearable power assist wear for lower limb The system requires compact size and lightweight to achieve a practical application, therefore we discuss its effective structure using biarticular muscle. At first, two model of targeting at support device for human lower limb is described, followed by showing each alignment of rubber artificial muscles. Next, construction force generated by rubber artificial muscles to achieve static balance is calculated. At the end, Experiment apparatus is designed from calculation and experimental results is showed.
en-copyright=
kn-copyright=

en-aut-name=InabaTomoya
en-aut-sei=Inaba
en-aut-mei=Tomoya
kn-aut-name=稲葉智也
kn-aut-sei=稲葉
kn-aut-mei=智也
aut-affil-num=1
ORCID=

en-aut-name=NoritsuguToshiro
en-aut-sei=Noritsugu
en-aut-mei=Toshiro
kn-aut-name=則次俊郎
kn-aut-sei=則次
kn-aut-mei=俊郎
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ. Dept. of System Engineering

affil-num=2
en-affil=
kn-affil=Okayama Univ. Dept. of System Engineering
en-keyword=Biarticular Muscle
kn-keyword=Biarticular Muscle
en-keyword=Rubber Artificial Muscles
kn-keyword=Rubber Artificial Muscles
en-keyword=Pneumatic Actuator
kn-keyword=Pneumatic Actuator
END

start-ver=1.4
cd-journal=joma
no-vol=391
cd-vols=
no-issue=1
article-no=
start-page=1142
end-page=1147
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100101
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Anterior cruciate ligament-derived cells have high chondrogenic potential
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Anterior cruciate ligament (ACL)-derived cells have a character different from medial collateral ligament (MCL)-derived cells. However, the critical difference between ACL and MCL is still unclear in their healing potential and cellular response. The objective of this study was to investigate the mesenchymal differentiation property of each ligament-derived cell. Both ligament-derived cells differentiated into adipogenic, osteogenic, and chondrogenic lineages. In chondrogenesis, ACL-derived cells had the higher chondrogenic property than MCL-derived cells. The chondrogenic marker genes, Sox9 and α1(II) collagen (Col2a1), were induced faster in ACL-derived pellets than in MCL-derived pellets. Sox9 expression preceded the increase of Col2a1 in both pellet-cultured cells. However, the expression level of Sox9 and a ligament/tendon transcription factor Scleraxis did not parallel the increase of Col2a1 expression along with chondrogenic induction. The present study demonstrates that the balance between Sox9 and Scleraxis have an important role in the chondrogenic differentiation of ligament-derived cells.
en-copyright=
kn-copyright=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HachiojiMotomi
en-aut-sei=Hachioji
en-aut-mei=Motomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SaigaKenta
en-aut-sei=Saiga
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakataNaoki
en-aut-sei=Takata
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YokoyamaYusuke
en-aut-sei=Yokoyama
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=3
en-affil=
kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=4
en-affil=
kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=5
en-affil=
kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=6
en-affil=
kn-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
en-keyword=Anterior cruciate ligament
kn-keyword=Anterior cruciate ligament
en-keyword=Medial collateral ligament
kn-keyword=Medial collateral ligament
en-keyword=Chondrogenesis
kn-keyword=Chondrogenesis
en-keyword=Sox9
kn-keyword=Sox9
en-keyword=Scleraxis
kn-keyword=Scleraxis
en-keyword=Differentiation
kn-keyword=Differentiation
END

start-ver=1.4
cd-journal=joma
no-vol=47
cd-vols=
no-issue=12
article-no=
start-page=3362
end-page=3373
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19351231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Heartfailure and its Treatment by Gymergen after Thyroidresection in Basedow's Disease
kn-title=バセドウ氏病ニ於ケル甲状腺切除手術後ノ心臟死竝ニ「ギネルゲン」ノ效果ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author experienced remarkable effects of Gynergen (Sandoz) in two cases of heartfailure after thyroidresection in Basedow's disease. Case 1. When the pulse of the patient became weak and frequent and the general condition was getting more serious after the operation, the author injected Gynergen (Sandoz) hypodermically, and found the quick improvement of the conditions both subjectively and objectively. Case 2. This case was a typical form of the vagotonic exophthalmic goitre after Eppinger and Haas in which goitre, cardiac disturbances, increased perspiration and chronic diarrhoea in long period were chief complaints without noticiable exophthalmos. The author performed thyroidresection when the basal metabolism was lowered by iodine treatment. Two days after the operation the irregular pulse was seen temporarily, but recovered by injection of Gynergen. On the fourth day after the operation suddenly appeared the symptom of socalled “Coma Basedowicum Zondek” and heart became quite out of order showing auricular fibrillation, perpetual arhythmia, ventricular and auricular extrasystole, and never recovered until death followed even by injections of Gynergen, physostigmin, quinine derivatives and other cardiacs and also blood transfusion as well. As an imoirtent factor of causal conditions of “Coma Basedowicum Zondek” the author believes that the changes of heart due to intoxication by thyroidsubstance play a Principal role. That is to say, the operative manipulation results easily temporary increase of thyroidsubstance in blood vessels, and the balance of metabolism may be broken, and on the other hand the disturbances of blood circulation of whole body due to the changes of heart accelerate the development of serious comatose condition like bulbar paralysis and lead to death. Observing the remarkable effect of Gynergen on the tachycardia and arhythmia after thyroidresection in Basedow's disease, the author recommends the clinical application of it in such cases.
en-copyright=
kn-copyright=

en-aut-name=HiraideShozo
en-aut-sei=Hiraide
en-aut-mei=Shozo
kn-aut-name=平井出正三
kn-aut-sei=平井出
kn-aut-mei=正三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學津田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=47
cd-vols=
no-issue=4
article-no=
start-page=1069
end-page=1093
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On the Action of Electric Current upon Organisms (3rd. Report.) On the Alternation of Permeability of Cell-membranes by Electric Current
kn-title=電流ノ生物ニ對スル作用ニ就テ（第3報）電流刺戟ニヨル細胞膜ノ透過性ノ變化ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The auther studied on alternation of permeability of cell-membranes by electric current and reached to the following results. 1) Plasmolysis of epithelial cells of Tradescantia virginica by hypertonic solution (0.5-1.0%) of sodium chloride will be stopped at the neighbourhood of the cathode by passing through of the electric current. 2) In the neighbourhood of cathode potassium-ions escape from the cells into the surrounding medium. It will be so understanded that the damage of semipermeability of the cell-membranes allows passage of anion and potassium-ion escapes in balance of it. Same thing occurs on the muscle cutaneus dorsi of frog. 3) Potassium-escape can be observed on the resting muscle of frog when the temperature of bathing fluid exceeds 29-32°C.
en-copyright=
kn-copyright=

en-aut-name=MoriNobutane
en-aut-sei=Mori
en-aut-mei=Nobutane
kn-aut-name=森信胤
kn-aut-sei=森
kn-aut-mei=信胤
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學生理學教室
END

start-ver=1.4
cd-journal=joma
no-vol=48
cd-vols=
no-issue=1
article-no=
start-page=13
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1936
dt-pub=19360131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On the nutritive value of yeast as adding substance to the diets of infants	( Part. II.) The nutritive value of yeast on growing white rats
kn-title=乳幼兒榮養添加料トシテノ酵母ノ價値ニ就テ　(第2)酵母ガ幼若白鼠ノ榮養發育ニ及ボス影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To determine whether the yeast added to the fairly well balanced food has any value, experimental studies were carried out on a series of young growing white rats which had been fed powdered milk with or without the addition of yeast. The yeast preparations used were “Enzeima” and “Ebios”. The animals with yeast and without yeast did not show any definite difference in their general and nutritional conditions, growths and other anatomical findings.
The animals which were fed powdered milk with the addition of sugar and polished cereal grain flour, showed a slightly increased rate in gain when the yeast preparation “Enzeima” was incorporated in their diet.
en-copyright=
kn-copyright=

en-aut-name=ItamiKungo
en-aut-sei=Itami
en-aut-mei=Kungo
kn-aut-name=伊丹訓吾
kn-aut-sei=伊丹
kn-aut-mei=訓吾
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學小兒科教室
END

start-ver=1.4
cd-journal=joma
no-vol=65
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=10
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201102
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Regulation of Mitochondrial Dynamics and Neurodegenerative Diseases
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Mitochondria are important cellular organelles in most metabolic processes and have a highly dynamic nature, undergoing frequent fission and fusion. The dynamic balance between fission and fusion plays critical roles in mitochondrial functions. In recent studies, several large GTPases have been identified as key molecular factors in mitochondrial fission and fusion. Moreover, the posttranslational modifications of these large GTPases, including phosphorylation, ubiquitination and SUMOylation, have been shown to be involved in the regulation of mitochondrial dynamics. Neurons are particularly sensitive and vulnerable to any abnormalities in mitochondrial dynamics, due to their large energy demand and long extended processes. Emerging evidences have thus indicated a strong linkage between mitochondria and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Huntington's disease. In this review, we will describe the regulation of mitochondrial dynamics and its role in neurodegenerative diseases.
en-copyright=
kn-copyright=

en-aut-name=HanXiao-Jian
en-aut-sei=Han
en-aut-mei=Xiao-Jian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TomizawaKazuhito
en-aut-sei=Tomizawa
en-aut-mei=Kazuhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujimuraAtsushi
en-aut-sei=Fujimura
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OhmoriIori
en-aut-sei=Ohmori
en-aut-mei=Iori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NishikiTei-ichi
en-aut-sei=Nishiki
en-aut-mei=Tei-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsushitaMasayuki
en-aut-sei=Matsushita
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatsuiHideki
en-aut-sei=Matsui
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=3
en-affil=
kn-affil=Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=4
en-affil=
kn-affil=Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=5
en-affil=
kn-affil=Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=6
en-affil=
kn-affil=Department of Molecular and Cellular Physiology, School of Medicine, University of the Ryukyus

affil-num=7
en-affil=
kn-affil=Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
en-keyword=mitochondria
kn-keyword=mitochondria
en-keyword=phosphorylation
kn-keyword=phosphorylation
en-keyword=ubiquitination
kn-keyword=ubiquitination
en-keyword=SUMOylation
kn-keyword=SUMOylation
en-keyword=neurodegeneration
kn-keyword=neurodegeneration
END

start-ver=1.4
cd-journal=joma
no-vol=3
cd-vols=
no-issue=3-4
article-no=
start-page=77
end-page=99
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1972
dt-pub=19720220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Dollar Problem and the U.S Balance of Payments
kn-title=ドル問題とアメリカの国際収支
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TatebeK.
en-aut-sei=Tatebe
en-aut-mei=K.
kn-aut-name=建部和弘
kn-aut-sei=建部
kn-aut-mei=和弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=3-4
article-no=
start-page=95
end-page=121
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1983
dt-pub=19830210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The New Deal and Budget- balancing Paradigm
kn-title=ニューディール財政と均衡予算主義
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HabuYoshito
en-aut-sei=Habu
en-aut-mei=Yoshito
kn-aut-name=土生芳人
kn-aut-sei=土生
kn-aut-mei=芳人
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=28
cd-vols=
no-issue=4
article-no=
start-page=103
end-page=127
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19970310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Credit Squeeze of 1973 after the Oil Crisis
kn-title=石油危機勃発後の1973年引締め―『日本銀行百年史　第六巻』の叙述について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Following another paper of mine* devoted to the analysis of the credit sqeeze in 1973 before the Oil Crisis, this paper deals with the developement of the sqeeze after the Oil Crisis. The main purpose is to compare the analysis of this paper with that of The Hundred Years of the Bank of Japan, vol. 6 (1986). Main concluding
remarks are as follows. 1 The recession after the Oil Crisis is mainly due to both the shrinkage of real-term consumption as the natural result of rapid inflation and the decline of willingness to invest. The latter, the decline of investment, is due to the anxiety about the high-cost of oil and the difficulty to secure it. The Hundred Years does not mention the above. 2 The Hundred Years discusses only little about the effect of the
reversed exchange control policy upon the improvement of overall balance of payments, whereas this paper attaches great importance to the mixed effect of reversed exchange control since Nov. 1973 and the raising of the Bank Rate by 2% in Dec. 1973. 3 As to the reason why the 9% Bank Rate had been maintained until April 1975, this paper infers, with a few indirect evidences, that it was necessary for the Bank, particularly, to retain, for some time, short- term foreign capital in the hands of foreign exchange banks to tide over the foreign currency reserves crisis since the fourth quarter of 1973. With regards to this question, The Hundred Years stresses only the significance of maintaining 9% to bring rapid inflation to a close. It does not mention the relation between the keeping of 9% and the international movement of money capital. *Atsushi Ichinose, The Credit Squeeze of 1973 before the Oil Crisis, Shikoku Gakuin Shakaikagaku Nenshi (Journal of Social Science), No 6,1996
en-copyright=
kn-copyright=

en-aut-name=IchinoseAtsushi
en-aut-sei=Ichinose
en-aut-mei=Atsushi
kn-aut-name=一ノ瀬篤
kn-aut-sei=一ノ瀬
kn-aut-mei=篤
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=28
cd-vols=
no-issue=4
article-no=
start-page=79
end-page=102
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19970310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=International Mal-adjustments and Japan's Protracted Lower Growth in 1990 s
kn-title=為替相場変動と経済不安定問題―「国際不調整」と日本の視点から―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=After temporally large decreasing in the early '90 s, current account imbalances abruptly had increased again above a hundred billion US dollars (yearly base) from 1993 to 1995 both in Japan (surpluses) and the United States (deficits). There have been some controversies over the cases of those imbalances among academic circles and some economists in economic think-tanks. One of the controversies is about a theoretical macro-balance. Those concerning long-term equilibrium approach emphasise structural factors on domestic gap between saving and investment balance of both the United States and Japan. On the contrary, those concerning short-term balance approach claim that external imbalances have been affected by short-term fluctuating factors, especially by the differential of both countries' economic growth. In line with the latter approach, this paper introduces a new concept of 'international mal-adjustments' on explaining about the problem of
such external imbalances. From the viewpoint of a realistic approach, intractable large-scale current account imbalances (more than two
percentages of GDP) of both Japan and the United States in recent years had been complained and claimed to be corrected by some important policy changes of both countries under the leadership of Clinton' administration since its inauguration in 1993. International mal-adjustments has been bringing big monetary and economic problems, in particular to Japanese economy. This paper depicts
such problems as yen's super appreciation and Japan's protracted zero or one percent economic growth in recent years.
en-copyright=
kn-copyright=

en-aut-name=TatebeKazuhiro
en-aut-sei=Tatebe
en-aut-mei=Kazuhiro
kn-aut-name=建部和弘
kn-aut-sei=建部
kn-aut-mei=和弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=2
article-no=
start-page=51
end-page=85
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19980910
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Accumulation of Local Debt and the Reform on the System of Accounts in Local Public Finance (2)
kn-title=地方債の累積と地方会計制度の改革（2, 完）―自治体のストック情報分析に向けて―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Following the last paper, we treat the problems of recent accumulation oflocal public debt in Japan and the reform on the system of accounts in local public finance. In this paper, we investigate the characteristic of the first budget bills of prefectural governments in 1998 fiscal year, and then we refer to the financial structures ofOkayama prefecture's budget bill. Following these analysis, we discuss the tasks of the establishment of balance-sheet in local government and the necessity to introduce the system of stock-accounts including double entry bookkeeping. In this point, the recent Report of Syakai-Keizai-Seisansei-Honbu and Mie prefecture's attempt on the settlement of finance with double entry bookkeeping are very interesting, but we must say that these attempts still have some problems to solve. In the last chapter, we discuss how to analyze the stock-position of local government finance and suggest to introduce Performance Budgeting System for the present.
en-copyright=
kn-copyright=

en-aut-name=SakamotoChuji
en-aut-sei=Sakamoto
en-aut-mei=Chuji
kn-aut-name=坂本忠次
kn-aut-sei=坂本
kn-aut-mei=忠次
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=31
cd-vols=
no-issue=4
article-no=
start-page=133
end-page=151
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=20000310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Structure and Implications of the Three Dimensional Double Entry Accounting System
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The essence of the Statement of cash flows required by FASB's Statement of financial accounting standards No. 95 in 1987 is the cash basis statement of changes in a financial position, because it must show the reconciliation between net income and CFO (Cash flow from
operations) in the main body or in the footnote of the statement. The year 1987 when the new basic financial statement appeared was the starting point from which the effort should be made to formulate new conceptual framework of financial accounting that accommodates three basic financial statements: the Balance sheet, Income statement, and the Statement of cash flows. However, little argument has been aroused toward this direction in the U. S. It is mainly because the traditional and conventional double entry bookkeeping system that is designed to prepare only the Balance sheet and the Income statements are deeply rooted to the conventional
accounting philosophy. This system can be called "two dimensional accounting system", one dimension for the Balance sheet and another dimension for the Income statement. What we need now is to construct an accounting system that can
produce all three basic financial statement at the same time. Such a system can be called "three dimensional double entry accounting system", and will be demonstrated in this paper. This 3 D accounting system can provide underlying basis for the Statement of cash flows as the basic
financial statement, in terms of the system of accounts as well as the conceptual structure.
en-copyright=
kn-copyright=

en-aut-name=SatohMichimasa
en-aut-sei=Satoh
en-aut-mei=Michimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=32
cd-vols=
no-issue=4
article-no=
start-page=101
end-page=123
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=20010310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Notes on Schumpeterian Competitive Power
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=There is a saying that 'look before you leap'. Though many economists look to be acquainted with the commonly accepted vision ofSchumpeter, I am wondering if it isn't time now to think over the appropriateness. His view about a certain mixed structure with monopoly and competition is the typical subject. In this paper I'll focus his logic of the competitive power I've seen in his several works. The main points are as follows. His competitive power vision is well understood by utilizing a certain meaning of 'rivalry' I call it. The reason is simply that this kind of power is agreeable to producing innovative activities. As some conclusions I will assert that Schumpeter's competitive power is filled with lots of splendid ideas for the modern economic theory. His prominent point, so to speak, consists in the balance between the innovative activities and the possible
equilibrium in rivalry.
en-copyright=
kn-copyright=

en-aut-name=TakemuraShosuke
en-aut-sei=Takemura
en-aut-mei=Shosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=33
cd-vols=
no-issue=4
article-no=
start-page=21
end-page=38
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Management Control Systems in Research and Development
kn-title=研究開発におけるマネジメント・コントロール・システムに関する考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In recent years, the role of research and development (R&D) activity has been increasing. Nevertheless, few papers have studied about management control systems in R&D. Management control systems in R&D will be examined in this paper. The main theme is how to design project control system that motivates R&D manager and people to strategic action. The structure of this paper is as follows. Based on literature review
about project planning and control process, the point at issue is Presented. Next, that issue is examined by using the concept of "Balanced Scorecard" and the results of researches in the innovation management area. Finally, the issues that should be further examined are pointed out.
en-copyright=
kn-copyright=

en-aut-name=MorofujiYumi
en-aut-sei=Morofuji
en-aut-mei=Yumi
kn-aut-name=諸藤裕美
kn-aut-sei=諸藤
kn-aut-mei=裕美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=34
cd-vols=
no-issue=4
article-no=
start-page=7
end-page=23
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Study on the Burden of the Public Debt in Japan through System of National Accounts
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This thesis will examine the economic and financial environment of the previous and current financial aggravation terms through macroeconomic data, namely, balance of saving and investment classified by institutional sectors in system of national accounts. It will also consider how far the concept of the burden of the public debt is applicable to Japanese actual economy. As long as measured by ex−post macroeconomic data, system of national accounts, though, there are a lot of
possibilities of evaluating the burden and it cannot be exactly said which evaluation such as neutrality theorem is both realistic and appropriate. However, the current financial aggravation term, compared with the previous term, seems to cope insufficiently with household financial deficit as far as mutual action about saving between each institutional sector is concerned. Although there is no need to say that further empirical analyses are essential, this includes important suggestions for examining the problems involved in the burden of the public debt. Firstly, incorporated business benefit trend in this prolonged period of economic slump is a critical factor. Secondly, taxation system and political and economic structure have more and more impact on household saving. Thirdly, it has become essential to show specific ways to fiscal reconstruction with social security−related
expenditure at its core, in order for household to adapt rationally to fiscal deficit. Therefore, it will be more crucial in further empirical analyses on the burden of the public debt to take into consideration these three points : benefit trend of incorporate business, political and economic structure, and policy operation such as public finance correction.
en-copyright=
kn-copyright=

en-aut-name=HiranoMasaki
en-aut-sei=Hirano
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=145
cd-vols=
no-issue=
article-no=
start-page=85
end-page=91
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20101025
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Approaches to Evaluating Trunk Muscle Power Balance
kn-title=体幹の筋力バランス評価の試み
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The purpose of the study was to evaluate trunk muscle power balance. Subjects is 7 university students(5 male: height 178.5±3.6cm, weight 74.0±8.5kg, 2female : height 157.0±8.4, weight 55.0±0) in this study. Trunk muscle power balance was evaluated using the Sling exercise therapy machine. F1 was weighted the upper part of their body with the scales. F2 was weighted the lower half of the body with the tension scales. The waist torque by change for position of Sling Point(SP) was increased about 1.3 times therefore SP was moved their toe. As to bilateral difference of trunk muscle power balance have a strong tendency to rotate left side motion the effect occurring most often right-handed.
en-copyright=
kn-copyright=

en-aut-name=MiuraKoji
en-aut-sei=Miura
en-aut-mei=Koji
kn-aut-name=三浦孝仁
kn-aut-sei=三浦
kn-aut-mei=孝仁
aut-affil-num=1
ORCID=

en-aut-name=KatayamaKeiko
en-aut-sei=Katayama
en-aut-mei=Keiko
kn-aut-name=片山敬子
kn-aut-sei=片山
kn-aut-mei=敬子
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学教育学研究科

affil-num=2
en-affil=
kn-affil=岡山大学教育学研究科
en-keyword=sling
kn-keyword=sling
en-keyword=trunk exercise
kn-keyword=trunk exercise
en-keyword=employing dialy action
kn-keyword=employing dialy action
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=
article-no=
start-page=3
end-page=7
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1972
dt-pub=19720325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A subsequent report on the new McKinney type mass spectrometer in the Institute for Thermal Spring Research, Okayama University
kn-title=温泉化学部門に設置した McKinney 型質量分析計のその後について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Since the installation in April 1970, the McKinney type mass spectrometer has maintained a good condition and about 5000 isotopic analyses of oxygen, carbon and sulfer has been cerried out so far. The ion source filament was changed to spiral one from single wire. Consequently three times sensitivity and the longer life of filament were obtained. Gradual changes in the ratio of potential divider (β) and the sensitivity (|△ E(0)(2)|/E(0)(1)) for the difference of β have been observed (Table 1). Because these changes are opposite in trend but similar in degree, it is supposed that these changes are caused by decrease of feed-back resister value in the balancing system. Although there remain some problems in the corrections for the difference in observed isotopic tatio between two cases that a same CO(2) is fed to ion source from the ST side of inlet system on the one hand and from the X side on the another, the reproducibility of the measurement of isotopic ratio for long period is
about ±O.1‰ (Table 2, Fig. 1). δ(18)O values of standard waters, MSA-1 and MSA-2, measured during a period from May to Dec. 1970 and in Sep. 1971 yielded good agreements implying the reproducibility of the measurement to be constant (Table 3). Both calculated δ(18)O values relative to a given sample based on each observed δ(18)O value relative to two different samples agreed each other. It is concluded that the linearity of observed a-value holds over a range of 30‰ (Table 4).
en-copyright=
kn-copyright=

en-aut-name=MatsubayaOsamu
en-aut-sei=Matsubaya
en-aut-mei=Osamu
kn-aut-name=松葉谷治
kn-aut-sei=松葉谷
kn-aut-mei=治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学温泉研究所温泉化学部門
END

start-ver=1.4
cd-journal=joma
no-vol=44
cd-vols=
no-issue=
article-no=
start-page=61
end-page=75
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1975
dt-pub=19750325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Oxygen Isotopic Composition of  Water in the Living Things : Preliminary Analyses and Discussions
kn-title=生物体内の水の酸素同位体組成
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Oxygen isotope analysis was carried out, by use of a new method (oxalate equilibration method) of preparing CO(2) for mass spectrometry, on water samples extracted from a number of biological samples collected in Misasa Town and Hashizu Coast, Tottori Prefecture. The δ values (the per mil enrichment of (18)O in sample waters relative to the Standard Mean Ocean Water) were suggested to be distributed in the living things as follows. The water absorbed by plant roots was supposed to have the same δ value with the water outside it (δs. about -8‰), and in a rapidly transpiring plant, this water reached the leaves, partly infiltrating into the phloem. When transpiration was slow, on the other hand, the isotopic composition of ascending xylem sap was modified by the exchange of water with phloem. where leaf water with a higher δ value was migrating. As Gonfiantini et aI. (1965) and Dongmann et al. (1972) have odserved, leaf waters were enriched markedly in (18)O in the daytime. A criterion of the δ of leaf water may be the sum of δs and △δ that corresponds to the (18)O fractionation factor in the H(2)O(I)-H(2)O(v) system. The sum comes to about 0‰ at ordinary leaf temperatures. and really δ values near 0‰ were observed in leaves of some herbaceous plants, in exudate from a tip of vine of Kudzu, in body fluid of herbivorous insects, etc., but higher δs (up to +19‰) were also observed in some other leaves such as pine needles, Especially leaves showed an increase in δ by about 10 ‰ toward the pnd of November when the average temperature fell below 10℃, probably because of accumulation of the daily enrichment as a resul t of slow water absorption and circulation. A few plant species grown on a dune were analyzed and it seemed that, among them, herbaceous plants were dependent on spraied sea water and pine trees on ground water. δ's of petal water were dispersed (-9～-3‰), probably according to the volume-to-transpirational flux ratio of water in the petals. Succurent fruits in enlarging stage seemed to have lower δ's near δs, but in maturing stagp δ's increaspd to about -4‰, i.e., to the avpraged δ of Ieaf water in the day and night. Herbivorous insects (imagines and la rvae) in general had distinctly higher δ values than carnivorous insects, the border being at -1‰. However, lower δ's at about -5‰ were obserbed on aphides which might have been sucking somewhat dilutpd leaf water from seave tube cells. Sometimes the δ of a herbivorous insect was a few per mil higher than that of the leaf it was nibbling, probably as a result of evaporation of water from the insect and of respiration. The level at about -3‰ common for carnivorous insects could not be explained, although tipula and chironomus making a swarm also showed a δ value on the level. Blood of a heron did not show such a low δ as supposed from its food habit. As compared with the drinking water of -8‰, blood and urine were found to have an identical δ in the range of -4 to -5‰ in either mouse or man, The δ value of the oxidation water produced in man's body was estimated to be about -6‰ from an approximate water balance.
en-copyright=
kn-copyright=

en-aut-name=KishimaNoriaki
en-aut-sei=Kishima
en-aut-mei=Noriaki
kn-aut-name=木島宣明
kn-aut-sei=木島
kn-aut-mei=宣明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学温泉研究所温泉化学部門
END

start-ver=1.4
cd-journal=joma
no-vol=64
cd-vols=
no-issue=3
article-no=
start-page=155
end-page=161
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=201006
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Epigenetic Regulation in Chondrogenesis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure. Condensed chromatin (heterochromatin), which has a higher-order histone-DNA structure, prevents the access of transcriptional activators to their target genes. The fundamental unit of eukaryotic chromatin consists of 146 bp of DNA wrapped around a histone octamer. Posttranslational modifications of the histone tail and the chromatin remodeling complex disrupt histone-DNA contacts and induce nucleosome mobilization. Histone acetylation of specific lysine residues in the histone tail plays a crucial role in epigenetic regulation. Histone acetylation is a dynamic process regulated by the antagonistic actions of 2 families of enzymes - the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). The balance between histone acetylation and deacetylation serves as a key epigenetic mechanism for transcription factor-dependent gene expression and the developmental process. We review emerging evidence that DNA methylation, histone acetylation modified by HAT and/or HDAC, and transcription factor-associated molecules contribute to a mechanism that can alter chromatin structure, gene expression, and cellular differentiation during chondrogenesis.
en-copyright=
kn-copyright=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
en-keyword=epigenetics
kn-keyword=epigenetics
en-keyword=DNA methylation
kn-keyword=DNA methylation
en-keyword=histone acetylation and HAT
kn-keyword=histone acetylation and HAT
en-keyword=histone deacetylation and HDAC
kn-keyword=histone deacetylation and HDAC
en-keyword=chondrogenesis
kn-keyword=chondrogenesis
END

start-ver=1.4
cd-journal=joma
no-vol=37
cd-vols=
no-issue=4
article-no=
start-page=321
end-page=333
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1983
dt-pub=198308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of a branched chain amino acid-enriched nutritional product on the pathophysiology of the liver and nutritional state of patients with liver cirrhosis.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>A new nutritional product (SF-1008C) containing a high proportion of branched chain amino acids (BCAA) and low proportion of aromatic amino acids (AAA) and methionine was tested to see its effect on the impaired protein metabolism and abnormal nutritional state frequently observed in patients with advanced liver cirrhosis. A sharp increase in plasma BCAA levels and fall of AAA and methionine levels were found following the administration of an SF-1008C-supplemented diet to healthy controls and cirrhotic patients, which the BCAA levels increased only slightly following an isocaloric control diet. Blood ammonia levels increased within the normal range transiently following the diets. The SF-1008C-supplemented diet was given for 2 weeks to cirrhotic patients with histories of hepatic encephalopathy, who were taking a low-protein diet because of hyperammonemia. Serum prealbumin levels, nitrogen balance, molar ratio of plasma BCAA/phenylalanine and tyrosine, the number connection test and electroencephalograms improved during the period of the experimental diet. The results, therefore, indicate that a BCAA-supplemented diet is well tolerated by patients with advanced cirrhosis and useful for treatment of impaired protein metabolism. Furthermore, this product is beneficial in preventing hepatic encephalopathy in cirrhotics.</p>

en-copyright=
kn-copyright=

en-aut-name=WatanabeAkiharu
en-aut-sei=Watanabe
en-aut-mei=Akiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShiotaTetsuya
en-aut-sei=Shiota
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkitaMisako
en-aut-sei=Okita
en-aut-mei=Misako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NagashimaHideo
en-aut-sei=Nagashima
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University

affil-num=4
en-affil=
kn-affil=Okayama University
en-keyword=branched chain amino acid
kn-keyword=branched chain amino acid
en-keyword=aromatic amino acid
kn-keyword=aromatic amino acid
en-keyword=nutritional product
kn-keyword=nutritional product
en-keyword=liver cirrhosis
kn-keyword=liver cirrhosis
en-keyword=hepatic encephalopathy
kn-keyword=hepatic encephalopathy
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=4
article-no=
start-page=189
end-page=195
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=200408
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Relationship between postural balance and knee and toe muscle power in young women.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Muscle power in the lower extremities and body sway were measured in 57 healthy young women volunteers in their 20's. Body sway was measured with a stabilimeter for 30 sec during two-leg standing, and for 10 sec during one-leg standing with the eyes open or closed, alternating between right and left legs (5 times each). The measured parameters of body sway were locus length per time unit, locus length per environmental area, environmental area, rectangle area, root mean square area, and the ratio of sway with eyes closed to sway with eyes open. Knee flexor and extensor power and toe flexor and abductor power were the measures representing lower extremity muscle power. The increase in sway with the eyes closed was more marked during one-leg standing than two-leg standing, as expected. We found that 36 of 57 subjects (62%) were unable to maintain one-leg standing with their eyes closed, and this failure correlated with marked body sway (P = 0.0086). Many subjects had one leg that was classified as stable and the other leg classified as unstable. Clearly, testing of both legs alternately with eyes closed is necessary to measure the full range of sway in subjects. Lower extremity muscle power did not appear to be the dominant factor in maintaining balance in these young subjects.</p>

en-copyright=
kn-copyright=

en-aut-name=KatayamaYoshimi
en-aut-sei=Katayama
en-aut-mei=Yoshimi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SendaMasuo
en-aut-sei=Senda
en-aut-mei=Masuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HamadaMasanori
en-aut-sei=Hamada
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KataokaMasaki
en-aut-sei=Kataoka
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ShintaniMai
en-aut-sei=Shintani
en-aut-mei=Mai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=InoueHajime
en-aut-sei=Inoue
en-aut-mei=Hajime
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University 

affil-num=4
en-affil=
kn-affil=Okayama University

affil-num=5
en-affil=
kn-affil=Okayama University

affil-num=6
en-affil=
kn-affil=Okayama University
en-keyword=postural balance
kn-keyword=postural balance
en-keyword=woman
kn-keyword=woman
en-keyword=lower extremity
kn-keyword=lower extremity
en-keyword=muscle power
kn-keyword=muscle power
END

start-ver=1.4
cd-journal=joma
no-vol=55
cd-vols=
no-issue=2
article-no=
start-page=97
end-page=103
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=200104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=In vitro transformation of rat renal cells by treatment with ferric nitrilotriacetate.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Administration of ferric nitrilotriacetate (Fe-NTA) in vivo causes acute renal tubular injury and finally induces renal cell carcinoma. There is accumulating evidence that these processes involve free radicals generated by Fe-NTA. To study the mechanism of renal carcinogenesis by Fe-NTA, we attempted to induce malignant transformation of primary cultured renal cells by treatment with Fe-NTA. When primary cultured renal cells (PRC) were treated continuously with Fe-NTA, all of the PRC died without transformation. On the other hand, when PRC were treated intermittently with Fe-NTA, transformed epithelial colonies were observed at 3 weeks after the first treatment. The established transformed cell line (RK523) showed drastic morphological transformation, grew in soft agar, and formed tumors when transplanted into athymic nude mice. These results indicate that the balance between cytotoxicity and mutagenecity is important for Fe-NTA induced transformation. The RK523 cell line may be a useful model for studying renal carcinogenesis in vitro.</p>

en-copyright=
kn-copyright=

en-aut-name=KakehashiChikako
en-aut-sei=Kakehashi
en-aut-mei=Chikako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MoriMasaharu
en-aut-sei=Mori
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KawabataTeruyuki
en-aut-sei=Kawabata
en-aut-mei=Teruyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OkadaShigeru
en-aut-sei=Okada
en-aut-mei=Shigeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Prefectural University

affil-num=2
en-affil=
kn-affil=Okayama Prefectural University

affil-num=3
en-affil=
kn-affil=Okayama University

affil-num=4
en-affil=
kn-affil=Okayama University
en-keyword=renal cell
kn-keyword=renal cell
en-keyword=  Fe-NTA(ferric nitrilotriacetate)
kn-keyword=  Fe-NTA(ferric nitrilotriacetate)
en-keyword=malignant transformation
kn-keyword=malignant transformation
en-keyword=in vitro
kn-keyword=in vitro
END

start-ver=1.4
cd-journal=joma
no-vol=63
cd-vols=
no-issue=6
article-no=
start-page=373
end-page=377
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=200912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Computer navigation-assisted spinal fusion with segmental pedicle screw instrumentation for scoliosis with rett syndrome:a case report
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Scoliosis is a common clinical manifestation of Rett syndrome, a neurodevelopmental disorder that almost exclusively affects females. The spinal curve in patients with Rett syndrome is typically a long C curve of a neuromuscular type. As the onset of the scoliosis is very early and shows rapid progression, early surgical intervention has been recommended to prevent a life-threatening collapsing spine syndrome. However, there are high perioperative risks in Rett syndrome patients who undergo spinal surgery, such as neurological compromise and respiratory dysfunction due to rigid spinal curve. We herein report the surgical result of treating severe rapid progressive thoracic scoliosis in a 16-year-old girl with Rett syndrome. Posterior segmental pedicle screw fixation was performed from T1 to L3 using a computer-assisted technique. Post-operative radiography demonstrated a good correction of the curve in both the sagittal and coronal alignment. There were no postoperative complications such as neurological compromise. The patient had maintained satisfactory spinal balance as of the 3-year follow-up examination.</p>
en-copyright=
kn-copyright=

en-aut-name=TanakaMasato
en-aut-sei=Tanaka
en-aut-mei=Masato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakanishiKazuo
en-aut-sei=Nakanishi
en-aut-mei=Kazuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SugimotoYoshihisa
en-aut-sei=Sugimoto
en-aut-mei=Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MisawaHaruo
en-aut-sei=Misawa
en-aut-mei=Haruo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakigawaTomoyuki
en-aut-sei=Takigawa
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NishidaKeiichiro
en-aut-sei=Nishida
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital

affil-num=2
en-affil=
kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital

affil-num=3
en-affil=
kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital

affil-num=4
en-affil=
kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital

affil-num=5
en-affil=
kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital

affil-num=6
en-affil=
kn-affil=Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=7
en-affil=
kn-affil=Department of Orthopaedic Surgery, Okayama University Hospital
en-keyword=Rett syndrome
kn-keyword=Rett syndrome
en-keyword=scoliosis
kn-keyword=scoliosis
en-keyword=computer navigation-assisted surgery
kn-keyword=computer navigation-assisted surgery
en-keyword=segmental pedicle screw fixation
kn-keyword=segmental pedicle screw fixation
END

start-ver=1.4
cd-journal=joma
no-vol=56
cd-vols=
no-issue=2
article-no=
start-page=75
end-page=82
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=200204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Kinesiological study of the push-up motion in spinal cord injury patients: involving measurement of hand pressure applied to a force plate.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>We studied the pressure exerted by hands during push-ups in 21 paraplegic and 2 tetraplegic patients employing 4 different hand positions. In the fingers-spread position, the initial force exerted was a vertical force (Fz), followed by a medio-lateral force (Fy) and then an antero-posterior force (Fx). In the other 3 positions, the order of force type exertion was Fz, Fx, and then Fy. All subjects with neurological injury levels above T4 and subjects between T5 and T10 without spinal instrumentation could not push themselves up in the fingers-spread position. The fact that Fy is initiated before Fx in the fingers-spread position indicates that lateral balancing of the trunk is critical in this position, thus explaining why subjects without spinal instrumentation with neurological injury at a level higher than T10 could not control their spinal columns while performing push-ups. In contrast, antero-posterior balancing takes priority in the other hand positions. We believe that spinal instrumentation helps balance the trunk in the lateral direction, converting the thoracic spine into a rigid body in subjects with neurological injury at levels above T10.
</p>
en-copyright=
kn-copyright=

en-aut-name=KotaniYasuhiro
en-aut-sei=Kotani
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TokuhiroAkihiro
en-aut-sei=Tokuhiro
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Kibikogen Rehabilitation Center for Employment Injuries
en-keyword=spinal-cord-injury
kn-keyword=spinal-cord-injury
en-keyword=rehabilitation
kn-keyword=rehabilitation
en-keyword=kinesiology
kn-keyword=kinesiology
en-keyword=push-up
kn-keyword=push-up
en-keyword=floor reaction force
kn-keyword=floor reaction force
END

start-ver=1.4
cd-journal=joma
no-vol=56
cd-vols=
no-issue=6
article-no=
start-page=287
end-page=294
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=200212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Decisional balance of condom use and depressed mood among incarcerated male adolescents.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>The association between depressed mood and condom use was examined among incarcerated male adolescents. One hundred and eighty male adolescents who were detained in Birmingham, Alabama in the United States were interviewed during a period of incarceration. Contrary to patterns generally found in adult samples, nearly 50% of this adolescent sample that did not use condoms regularly actually recognized the advantages of condom use. This behavior pattern was deemed &#34;inconsistent,&#34; and those engaging in this &#34;inconsistent&#34; behavior pattern were found to have a higher score of depressed mood compared to participants with a &#34;consistent&#34; behavior pattern. As a result, a relationship between depressed mood and decisional balance for condom use within adolescents was evident. These findings suggest that assessment and treatment of depressed mood within this high-risk population could potentially contribute to a reduction in high-risk sexual behaviors.</p>

en-copyright=
kn-copyright=

en-aut-name=NagamuneNoriyo
en-aut-sei=Nagamune
en-aut-mei=Noriyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=BellisJeffrey M.
en-aut-sei=Bellis
en-aut-mei=Jeffrey M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=University of Alabama at Birmingham
en-keyword=incarcerated adolescents
kn-keyword=incarcerated adolescents
en-keyword=stages of change
kn-keyword=stages of change
en-keyword=depressed mood
kn-keyword=depressed mood
en-keyword=condom use
kn-keyword=condom use
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=3
article-no=
start-page=192
end-page=217
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1957
dt-pub=195709
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Studies on the Basal Metabolism in the Patients after the Operation of Cervical Carcinoma, Especially on the Effects of Autotransplantation of the Ovary and Castration
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>The evaluations of the basal metabolism before the operation, at the completion, and at the follow-up examinations, have been conducted on the patients with cervical carcinoma, all under the age of 50 years, and
operated on in the Clinics of Obstetrics and Gynecology, Okayama University Medical School and the following results are obtained: 1. The basal metabolism of the patients with cervical carcinoma of either stage I or stage II as compared with that of the normal women is
more accelerated; while the basal metabolism of the cervical carcinoma of stage II. is more augmented than that of the cervical carcinoma stage I. 2. The basal metabolism at the completion of operation is markedly
lower than that before the operation. 3. In those who received the autotransplantation of the ovary concomitantly
with operation, the basal metabolism once increases at the 4th month after the operation and after that it maintains a low stable state. 4. The basal metabolism of those who received the operative castration continues increasing up to the 8th month after the operation and thereafter it returns to a rather balanced state. 5. From the aspects of the fluctuations of the basal metabolism, it has been recognized that the autotransplantation as compared with the castration exerts less influences on the somatic system and for a shorter period of time, and also the endocrine system of the former returns to the balanced condition earlier.</p>

en-copyright=
kn-copyright=

en-aut-name=HigashiSusumu
en-aut-sei=Higashi
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=39
cd-vols=
no-issue=1
article-no=
start-page=59
end-page=65
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=198502
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A vegetable protein-rich diet for the treatment of liver cirrhosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Twelve patients were administered a vegetable protein-rich diet, which was low in methionine and high in the branched-chain amino acid (BCAA) to aromatic amino acid (AAA) molar ratio, and an animal protein-rich diet, high in methionine and low in the BCAA/AAA molar ratio. These diets were administered successively for one week each. Actually ingested amounts of tyrosine and methionine were significantly lower during the feeding of the vegetable protein-rich diet than the animal protein-rich diet. Serum methionine concentrations increased while on the animal protein-rich diet and decreased following the switch to the vegetable protein-rich diet. No other amino acid concentrations were affected. Significant differences were not observed in nitrogen balance or serum protein concentrations.</p>

en-copyright=
kn-copyright=

en-aut-name=OkitaMisako
en-aut-sei=Okita
en-aut-mei=Misako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WatanabeAkiharu
en-aut-sei=Watanabe
en-aut-mei=Akiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NagashimaHideo
en-aut-sei=Nagashima
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University 

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okyama University
en-keyword=vegetable protein
kn-keyword=vegetable protein
en-keyword=methionine
kn-keyword=methionine
en-keyword=branched-chain amino acids
kn-keyword=branched-chain amino acids
en-keyword=liver cirhosis
kn-keyword=liver cirhosis
en-keyword=dietary treatment
kn-keyword=dietary treatment
END

start-ver=1.4
cd-journal=joma
no-vol=39
cd-vols=
no-issue=3
article-no=
start-page=179
end-page=190
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=198506
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of Talbot's Safety Zone of Infusion Volume and Osmolality in Infusion Therapy for Decompensated Liver Cirrhosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Problems with infusion therapy for correcting fluid and sodium imbalance in decompensated liver cirrhosis (DLC) were investigated by establishing the safety zone of Talbot et al. for parenteral fluid therapy in 4 DLC patients infused with over 900 ml of fluid each day for at least 9 days. The safety zone was different in each case. The safe infusion volume decreased and the safe electrolyte concentration shifted to a lower osmolality when there was ascites with renal failure than ascites without renal failure. Infusion therapy was performed without deterioration of the water and sodium balance in those patients whose infusion volume and fluid osmolality were in the safety zone. In contrast, ascites retention increased and peripheral edema appeared in patients whose infusion volume and osmolality were out of the safety zone. Therefore, the safety zone should be determined repeatedly during infusion therapy.</p>

en-copyright=
kn-copyright=

en-aut-name=YuasaShiro
en-aut-sei=Yuasa
en-aut-mei=Shiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ItoshimaTatsuya
en-aut-sei=Itoshima
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoRyosaku
en-aut-sei=Ono
en-aut-mei=Ryosaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NagashimaHideo
en-aut-sei=Nagashima
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama  University

affil-num=3
en-affil=
kn-affil=Okayama University

affil-num=4
en-affil=
kn-affil=Okayama University
en-keyword=decompensated liver cirrhosis
kn-keyword=decompensated liver cirrhosis
en-keyword=infusion therapy
kn-keyword=infusion therapy
en-keyword=ascites
kn-keyword=ascites
en-keyword=hepatorenal syndrome
kn-keyword=hepatorenal syndrome
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=5
article-no=
start-page=335
end-page=344
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=196110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Studies on respiratory humidity. II. Humidity in anesthetic circuits and water loss via anesthesia systems
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Through the use of an automatic photo tube dew-point hygrometer, the author succeeded in measuring dew point of gas flows continuously in anesthetic circuits. Simultaneous thermometries were done on the nasal or oral mucosa, on the respiratory gas flows in the anesthetic mask or the endotracheal tube, and on the gas in the inhaling conduit. Experiments were performed on ten adults patients undergoing various types of surgery under general inhalation anesthesia. Anesthetic technics were varied intentionally during the measurements. Thus, both absolute and relative humidities of exhaled and inhaled gases,
and respiratory water and heat losses were calculated under various anesthetic conditions, and physiological and clinical considerations were discussed. The conclusions obtained from this research are as follows: (1) When a non-rebreathing system is applied, moisture content of exhaled
gas is minimal, and respiratory losses of both water and heat are maximum. With a semi-closed circle method, according to decreasing fresh gas flows, the humidity of the inspiratory and expiratory gases becomes higher, and both heat and water losses through respiration are lessened. When a closed circle method, with carbon dioxide absorption, is employed, temperature and humidity of gas
in the inhaling conduit are highest, and the expired gas offers the maximum temperature and moisture contenL Both water and heat losses from anesthesia become minimal when administered in a closed system. (2) While the water and heat that a patient loses through respiration increase with increasing breathing capacity, they are still small parts of the total water and heat losses of the patient. Water and heat losses via anesthesia systems are not so predominant in maintaining water balance and heat regulation of patients during anesthesia and surgery.</p>

en-copyright=
kn-copyright=

en-aut-name=SatoToru
en-aut-sei=Sato
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=5
article-no=
start-page=279
end-page=283
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=199810
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Expression of amiloride-sensitive sodium channel in rat eye.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>To study the expression of the amiloride-sensitive sodium channel, a putative mechano-receptor in the rat eye, reverse transcriptase-polymerase chain reaction and in situ hybridization were done. The gene for the alpha subunit of the amiloride-sensitive sodium channel was shown by polymerase chain reaction to be expressed in mRNA isolated from the whole eye tissue. In situ hybridization demonstrated that the gene was expressed in basal layers of the corneal and conjunctival epithelium, ciliary epithelial cells, lens epithelial cells at the equator, retinal and iris pigment epithelial cells, ganglion cells and cells in the inner and outer nuclear layers of the retina. The results suggest that the amiloride-sensitive sodium channel plays a role in maintaining sodium balance as well as in possible mechanosensation in these ocular tissues.</p>

en-copyright=
kn-copyright=

en-aut-name=MatsuoToshihiko
en-aut-sei=Matsuo
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama  University
en-keyword=amiloride-sensitive sodium channel
kn-keyword=amiloride-sensitive sodium channel
en-keyword=eye
kn-keyword=eye
en-keyword=insitu hybridzation
kn-keyword=insitu hybridzation
en-keyword=mechanosensation
kn-keyword=mechanosensation
en-keyword=polymerase chain reaction
kn-keyword=polymerase chain reaction
END

start-ver=1.4
cd-journal=joma
no-vol=25
cd-vols=
no-issue=5
article-no=
start-page=551
end-page=566
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1971
dt-pub=197110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Clinical and experimental studies on folic acid deficiency due to anticonvulsants. 2. Investigations on patients receiving anticonvulsants and experimental study on the effect of diphenylhydantoin on the absorption of folic acid in rats
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>A high incidence of subnormal serum folic acid levels was observed in 48 patients receiving anticonvulsants (75 %). In peripheral blood, macrocytosis was detected in 46 % and an increase of hypersegmented neutrophils was also seen in 24 % of the patients. Correlation existed between these signs and low serum folate levels. The growth response of Lactobacillus casei and L. leichmannii was not suppressed by the addition of various anticonvulsants to the medium of the bioassay systems. Administration of 5 mg of folic acid for a month corrected macrocytosis and an increase of hypersegmented neutrophils significantly. Folic acid supply also decreased mean diameters of the nuclei of oral epithelial cells significantly. It is concluded that subclinical folic acid deficiency is common among the patients receiving anticonvulsants. Absorption of 3H.folic acid from the small intestine of rats was inhibited by large dose of diphenylhydantoin (20 mg) not by 5 mg. This fact suggests that in patients on diphenylhydantoin, the quantity balance of folic acid and diphenylhydantoin in the intestine regulates the absorption of folic acid.</p>

en-copyright=
kn-copyright=

en-aut-name=TaguchiHirokuni
en-aut-sei=Taguchi
en-aut-mei=Hirokuni
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=62
cd-vols=
no-issue=3
article-no=
start-page=175
end-page=184
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200806
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inferred Influence of Human Lateral Profile on Limb Load Asymmetry during a Quiet Standing Balance Test
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Although the identification and characterisation of a participant's lateral profile during quiet standing have not received much research attention, they have the potential to greatly extend our understanding of upright stance stability control. This study further examines limb load asymmetries during quiet bipedal stance. During voluntary frontal-plane weight shifting for 2 min, 300 centre-of-pressure displacements on 14 blindfolded right-handed young adults were recorded. Four biomechanical indices were used to assess postural behaviour. These were the bias of time and the magnitude of the partial ground reaction forces from both legs, and the bias in the number and magnitude of microshifts influencing stability. Our study identifies a significant level of asymmetry in the quiet bipedal stance of right-handed people. This asymmetry is associated with the right-sided bias of the ground reaction force and the angle of inclination to the upright (vertical) centroidal line. We found that the initial lateralisation of the partial ground reaction forces from both feet, as well as the period of ground reaction force bias, are important elements in any clinical tests involving quiet bipedal stance.</p>
en-copyright=
kn-copyright=

en-aut-name=GutnikBoris
en-aut-sei=Gutnik
en-aut-mei=Boris
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=LeaverJonathan
en-aut-sei=Leaver
en-aut-mei=Jonathan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=StandenClive
en-aut-sei=Standen
en-aut-mei=Clive
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=LongleyChristopher
en-aut-sei=Longley
en-aut-mei=Christopher
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=School of Health Science, Unitec NZ

affil-num=2
en-affil=
kn-affil=School of the Built Environment, Unitec NZ

affil-num=3
en-affil=
kn-affil=School of Health Science, Unitec NZ

affil-num=4
en-affil=
kn-affil=School of Health Science, Unitec NZ
en-keyword=laterality
kn-keyword=laterality
en-keyword=asymmetry
kn-keyword=asymmetry
en-keyword=handedness
kn-keyword=handedness
en-keyword=stability
kn-keyword=stability
en-keyword=force
kn-keyword=force
END

start-ver=1.4
cd-journal=joma
no-vol=62
cd-vols=
no-issue=5
article-no=
start-page=297
end-page=302
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200810
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Optimal Temperature of Graft Preservation after ex Vivo Gene Transfer in Lung Isografts
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>The aim of this study was to determine the optimal temperature of graft preservation after ex vivo gene transfer to rat lung isografts. Left lungs were harvested and infused with cationic lipid/LacZ-DNA complex via the pulmonary artery, and the grafts were stored for 4h. The grafts (n＝7) were allocated into groups IﾝIV according to the storage temperature:4℃, 10℃, 16℃, and 23℃, respectively.
Forty-eight h after orthotopic transplantation, the arterial blood gas was analyzed and the peak airway pressure (PAP) and the level of LacZ protein production in the grafts were measured by reverse transcription polymerase chain reaction. After reperfusion, the grafts were stained with hematoxylin and eosin. The grafts in groups III and IV showed more deterioration as evidenced by decreased arterial oxygen tension, increased PAP, and predominant infiltration of inflammatory cells compared with groups I and II. The level of LacZ production was significantly lower in group I than in groups IIﾝIV. The optimal temperature of lung graft preservation after ex vivo gene transfer was determined to be 10℃, balancing considerations of lung injury and efficiency of transgene expression.</p>
en-copyright=
kn-copyright=

en-aut-name=OsaragiTomohiko
en-aut-sei=Osaragi
en-aut-mei=Tomohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NagahiroItaru
en-aut-sei=Nagahiro
en-aut-mei=Itaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MiyaguchiNaoyuki
en-aut-sei=Miyaguchi
en-aut-mei=Naoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MoriHideaki
en-aut-sei=Mori
en-aut-mei=Hideaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SanoYoshifumi
en-aut-sei=Sano
en-aut-mei=Yoshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=DateHiroshi
en-aut-sei=Date
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ShimizuNobuyoshi
en-aut-sei=Shimizu
en-aut-mei=Nobuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=3
en-affil=
kn-affil=Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=4
en-affil=
kn-affil=Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=5
en-affil=
kn-affil=Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=6
en-affil=
kn-affil=Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=7
en-affil=
kn-affil=Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
en-keyword=lung transplantation
kn-keyword=lung transplantation
en-keyword=gene transfection
kn-keyword=gene transfection
en-keyword=optimal temperature
kn-keyword=optimal temperature
en-keyword=organ preservation
kn-keyword=organ preservation
END

start-ver=1.4
cd-journal=joma
no-vol=36
cd-vols=
no-issue=5
article-no=
start-page=383
end-page=397
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=198210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Cytogenetic and Dermatoglyphic Studies on Severely Hand­icapped Patients in an Institution
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Cytogenetic and dermatoglyphic studies were performed on a group of 197 institutionalized patients with severe mental and physical handicaps in order to evaluate the contribution of chromosomal aberrations on the etiology of the condition, and to determine whether any association exists between the dermatoglyphics and the severe handicaps. There were 4 patients with trisomy 21 and 2 patients with a de novo balanced reciprocal translocation. In addition, 9 patients were found to have a pericentric inversion of chromosome 9 (inv (9) (p11q13)). Other chromosome variations identified included inv (1) (p11q11) (one case), elongation of 1 qh (one case), and telocentric chromosome 13 (two cases). Dermatoglyphics from the patients excluding cases with Down syndrome were compared with those from 500 normal controls. Significant differences were observed in several dermatoglyphic characteristics, including simian crease, fingertip pattern, mean a-b ridge count, thenar/first interdigital pattern, hypothenar pattern, and hallucal pattern. The present study indicated that de novo balanced translocation as well as chromosome duplication or deficiency is causally related to the severe combined handicaps. This study also showed that the incidence of inv (9) (p11q13) in the patients was 4.2 times higher than that in the general Japanese population. If a real association exists between the inv (9) (p11q13) and severe handicaps, the increase of inv (9) (p11q13) in the patients may be explained by the concept of a risk factor. Moreover, the dermatoglyphic deviations found in patients may be evidence that pathological factors had been operating during early embryonic life in some of them.</p>

en-copyright=
kn-copyright=

en-aut-name=KodamaYoshifumi
en-aut-sei=Kodama
en-aut-mei=Yoshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
en-keyword=chromosomes
kn-keyword=chromosomes
en-keyword=banding techniques
kn-keyword=banding techniques
en-keyword=dermatoglyphics
kn-keyword=dermatoglyphics
en-keyword=severely handicapped patients
kn-keyword=severely handicapped patients
END

start-ver=1.4
cd-journal=joma
no-vol=49
cd-vols=
no-issue=3
article-no=
start-page=129
end-page=135
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=199506
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Kinesiological Study of Push-up Motion Using a Three-Dimensional Floor Reaction on a Force Plate
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>To find an effective way to handle wheelchairs, 3-dimensional floor reactions of the hand and angular deviation of the elbow and wrist joints during push-up motion were studied in 10 healthy men. The push-up was carried out using 3 hand positions (fist, finger and palm) and a push-up device. In all hand positions, anteroposterior force (Fx) and the mediolateral force (Fy) appeared after the vertical force (Fz). The end point of Fx and Fy was observed before that of Fz. Among the 4 different hand positions, Fx and Fy appeared first in the palm, followed by the finger and fist positions, and lastly in the push-up devices. The results indicate that the more unstable pushing-up the body is, the earlier and longer Fx and Fy are. Thus, Fx and Fy are considered to be good indicators of body balance during the push-up motion. The elbow joint showed a hyperextended position only when using the palm position in the maintenance phase. The wrist joint showed palmar flexion only when using the fist position.</p>

en-copyright=
kn-copyright=

en-aut-name=IkawaHarutomo
en-aut-sei=Ikawa
en-aut-mei=Harutomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TokuhiroAkihiro
en-aut-sei=Tokuhiro
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama  University

affil-num=2
en-affil=
kn-affil=Okayama  University
en-keyword=force plate
kn-keyword=force plate
en-keyword=push-up montion
kn-keyword=push-up montion
en-keyword=body balance
kn-keyword=body balance
en-keyword=three-dimensional floor reaction of the hand
kn-keyword=three-dimensional floor reaction of the hand
END

start-ver=1.4
cd-journal=joma
no-vol=3
cd-vols=
no-issue=
article-no=
start-page=1535
end-page=1540
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Study of an intelligent hexapod walking robot
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Concerns a hexapod walking robot designed for use in living and working spaces where it is necessary to ascend and descend structures such as stairs. It is designed to carry loads while always maintaining horizontal balance. It has eight CPUs for controlling the movement of twenty driving motors and for detecting attitude and its environment. It can move around autonomously as well as according to the operator's commands. The robot's configuration, structure and mechanism, and intelligence, are discussed</p>

en-copyright=
kn-copyright=

en-aut-name=TanakaYutaka
en-aut-sei=Tanaka
en-aut-mei=Yutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatobaYasunori
en-aut-sei=Matoba
en-aut-mei=Yasunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University
en-keyword=attitude control
kn-keyword=attitude control
en-keyword=mobile robots
kn-keyword=mobile robots
en-keyword=position control
kn-keyword=position control
END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=16
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100625
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On stabilization of chaotic economic growth using capital nationalization and birth control
kn-title=国有化と産児制限によるカオス的経済成長の安定化について
en-subtitle=
kn-subtitle=
en-abstract=This paper investigates a policy mix of two macroeconomic policies in an overlapping generations economy with production. One policy is that the government nationalizes assets such as productive capital or land and lends them perpetually to the private sector. The other one is to control the rate of population growth via e.g. birth control. Generally, in a simple OLG economy with no government, the steady states do not necessarily satisfy the golden rule, which is a criterion for optimality. However, one of the steady states generated by the first policy does satisfy the golden rule criterion. Nonetheless, the golden rule steady state does not necessarily possess dynamic stability, and may be contained in a chaotic invariant set. Especially, in the last mentioned case, we examine how to synchronize the irregularly fluctuating growth paths to the golden rule balanced growth path. To do this, our second policy fine-tunes the population growth rate in arbitrarily small amplitude, making use of the OGY method, which exploits the features of chaos.
kn-abstract=生産を含む世代重複モデルにおいて，２つのマクロ政策の混合を検討する。ひとつは，政府が資本や土地などの資産を国有化し，民間部門に永続的に貸与することである。もうひとつは，産児制限などにより人口成長率を制御することである。政府が存在しない単純な経済では，一般に定常状態は，ひとつの最適性の条件である黄金律を満たさないが，第１の政策により発生する定常状態のひとつは黄金律を満たす。しかし，その黄金律定常状態は，必ずしも動学的安定性を持たず，場合によっては，カオス的な不変集合に含まれる。特にそのような場合に，第２の政策として，カオスの特性を利用するOGY 法を援用することで，人口成長率を任意に小さな振れ幅で制御しながら，不規則に変動する成長循環経路を黄金律均斉成長経路に同期させる方法を議論する。
en-copyright=
kn-copyright=

en-aut-name=YokooMasanori
en-aut-sei=Yokoo
en-aut-mei=Masanori
kn-aut-name=横尾昌紀
kn-aut-sei=横尾
kn-aut-mei=昌紀
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=47
cd-vols=
no-issue=12
article-no=
start-page=953
end-page=958
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19981205
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Kinetic study of the formation of triphenylmethanols from cationic triphenylmethane dyes in the presence of nonionic surfactant micelles
kn-title=非イオン界面活性剤ミセル存在下におけるトリフェニルメタン系陽イオン染料からトリフェニルメタノール生成の速度論的研究
en-subtitle=
kn-subtitle=
en-abstract=トリフェニルメタン系陽イオン染料から対応するトリフェニルメタノールへの加水分解反応について,非イオン界面活性剤ミセルの効果を速度論的に検討した.非イオン界面活性剤であるTriton X-100,PONPE-20,Brij-35,Brij-58のミセルが存在する水溶液中では,上記反応速度は陽イオン界面活性剤(STMA(+)) ミセルの存在下と同程度に促進された.非イオン界面活性剤の中ではTriton X-100が最も効果が高く,水酸化物イオンとの反応速度は10(2.0)～10(3.7)倍増加した.検討した5種類のトリフェニルメタン系陽イオン染料の中では,マラカイトグリーン,ブリリアントグリーンで反応が大きく促進された.又,ミセルを形成する非イオン界面活性剤分子の疎水性バランスの増加とともに反応速度は増加した.これは,生成したトリフェニルメタノールがミセルのコアをなす疎水性部に取り込まれやすい場合ほど,反応速度が促進されるものと考えられる.
kn-abstract=The formation rates of triphenylmethanols from corresponding cationic triphenylmethane dyes were investigated in the presence of nonionic surfactant micelles, such as Triton X-100, PONPE-20, Brij-35 and Brij-58. The increases in the formation rates of triphenylmethanols with the hydroxide ion in a nonionic micellar solution were almost comparable to that in the presence of a cationic micelle of stearyltrimetylammonium ion. The increase in the rate was largest with Triton X-100, and the rates with the hydroxide ion increased on the order of about 10(2.0)10(3.7) fold compared with those in an aqueous solution. The reaction rates for malachite green and brilliant green increased most significantly among the five dyes examined. The rates also increased along with an increase in the hydrophobicity (lipophilicity) balance of the surfactant molecule. These results indicate that the cationic dyes are adsorbed on the hydrophobic core of the surfactant micelle, and that the formed triphenylmethanols are incorporated in the core.
en-copyright=
kn-copyright=

en-aut-name=TakayanagiToshio
en-aut-sei=Takayanagi
en-aut-mei=Toshio
kn-aut-name=高柳俊夫
kn-aut-sei=高柳
kn-aut-mei=俊夫
aut-affil-num=1
ORCID=

en-aut-name=MiyaTomoko
en-aut-sei=Miya
en-aut-mei=Tomoko
kn-aut-name=宮智子
kn-aut-sei=宮
kn-aut-mei=智子
aut-affil-num=2
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学
en-keyword=nonionic surfactant micelle
kn-keyword=nonionic surfactant micelle
en-keyword=triphenylmethane dye
kn-keyword=triphenylmethane dye
en-keyword=kinetics
kn-keyword=kinetics
en-keyword=acceleration
kn-keyword=acceleration
END

start-ver=1.4
cd-journal=joma
no-vol=33
cd-vols=
no-issue=1
article-no=
start-page=39
end-page=45
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19981130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Recognition Index of Part and Unit by Discrimination Characteristics
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper, we propose a recognition index to evaluate the complexity of discrimination among parts and units. The parts and units are classified into some groups (the number of groups is shown as n) by one characteristic, such as color, shape, size and so on. The recognition index of each is denoted as log(2) (n+1) by the information quantity formula. The recognition diagram shows the classfication of parts and units into only one part and unit by the structure of a characteristic. Further we propose the line balancing method for assembly line based on the working time and recognition index.
en-copyright=
kn-copyright=

en-aut-name=MunesawaYoshiomi
en-aut-sei=Munesawa
en-aut-mei=Yoshiomi
kn-aut-name=宗澤良臣
kn-aut-sei=宗澤
kn-aut-mei=良臣
aut-affil-num=1
ORCID=

en-aut-name=OsakiHirokazu
en-aut-sei=Osaki
en-aut-mei=Hirokazu
kn-aut-name=大崎紘一
kn-aut-sei=大崎
kn-aut-mei=紘一
aut-affil-num=2
ORCID=

en-aut-name=KajiharaYasuhiro
en-aut-sei=Kajihara
en-aut-mei=Yasuhiro
kn-aut-name=梶原康博
kn-aut-sei=梶原
kn-aut-mei=康博
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Systems Engineering

affil-num=2
en-affil=
kn-affil=Department of Systems Engineering

affil-num=3
en-affil=
kn-affil=Department of Systems Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=8
article-no=
start-page=1157
end-page=1167
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19560831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Study on the Acute Pancreatic Necrosis. 2. Study of Electrolytic Balances, especially Serum Chlorideand Sodium
kn-title=実験的急性膵臓壊死に於ける血清内無機物質の消長に就て 第2編 血清内クロール，ナトリウムの消長に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Entirely the same method was used in this series. Serum chloride was measured by the silver-iodate method and serum sodium by the uranyl zinc acetate method. It was found that serum chloride decreased in experimental pancreatic necrosis. Progressive decrease was observed in the severe group. Following early immediate decrease after the onset of pancreatic necrosis and subsequent return to the preexperimental level, serum chloride decreased once again. The lowest value occurred on the 3rd day and then gradually returned to the normal level. It was observed that serum sodium decreased in experimental pancreatic necrosis. There was found no marked change in serum sodium in the severe group. No definite change occurred in the early stage of experimental disease in the mild group, but it decreased 12 and 24 hours later. The lowest value on the average occurred on the 2nd day of disease and then it gradually returned to the preexperimental value.
en-copyright=
kn-copyright=

en-aut-name=FukudaNanao
en-aut-sei=Fukuda
en-aut-mei=Nanao
kn-aut-name=福田七生
kn-aut-sei=福田
kn-aut-mei=七生
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部津田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=8
article-no=
start-page=1143
end-page=1155
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19560831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Study on the Acute Pancreatic Necrosis. Ⅰ. Study of. Electrolytic Balances, especially Serum Calcium and Potassium
kn-title=実験的急性膵臓壊死に於ける血清内無機物質の消長に就て 第1編 血清内カルシウム，カリウムの消長に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Study of electrolytic balances in experimental pancreatic necrosis were done on dogs. Acute pancreatic necrosis was produced by injecting olive-oil or bile obtained from the experimental animal into the pancreatic duct. Experimental animals were divided into the two groups, one, in which severe pancreatic necrosis was produced and most of which died shortly after experiment, and the other one, in which mild pancreatic necrosis was produced and all of which survived the experiment. Serum calcium was periodically measured by the phosphate method and serum potassium by the cobalt nitrate method. It was found that serum calcium generally decreased after the onset of pancreatic necrosis. However, it was not always found in the most severe cases, which all died shortly after the experiment, but maximum decrease developed on the third day of the experiment in mild cases and there was found no tendency to return to the level before the experiment. Serum potassium decreased temporarily at the beginning of experimental pancreatic necrosis and then it again increased between 6 and 12 hours later. In the severe group, this increase of serum potassium was marked and animals died at that time. On the other hand, serum potassium returned to the level before the experiment between 12 and 48 hours in the mild group and then it again decreased. The maximum decrease occurred on the third day of experiment and then returned to normal level.
en-copyright=
kn-copyright=

en-aut-name=FukudaNanao
en-aut-sei=Fukuda
en-aut-mei=Nanao
kn-aut-name=福田七生
kn-aut-sei=福田
kn-aut-mei=七生
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部津田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=5-1
article-no=
start-page=2315
end-page=2324
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590415
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Study on Gastric Pepsin and Uropepsin Part Ⅰ. The Influence of Cancer Extract upon Gastric Pepsin
kn-title=胃液ペプシンとウロペプシンに関する実験的研究 第1編 癌エキスの胃液ペプシンに対する影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1. Four mature dogs, weighing 10 to 12 kg, were anesthetized with "Zyclopan" and fractional aspiration of the gastric juice was performed through Levine's tube. On the other hand, secretion from the pouch which was previously prepared on the stomach of 30 dogs in Wedge or Heidenhain's method was collected at every 10 or 20 minutes. When the profuse secretion started about 1 hour later, 10 % cancer extract was injected intravenously into the leg vein of the dog in a dose of 1 cc of the extract per kg weight of the dog. The aspiration was continued for more three hours after the injection of the cancer extract in all cases. Volume of the specimen and its peptic activity were measured. 2. As a result of intravenous injection of cancer extract, the gastric pouch secretion decreased moderately and its peptic activity was depressed gradually. In most instances, peptic activity showed the maximum depression between 40 and 60 minutes after the injection, followed by gradual increase, and finally 3 hours after recovered to almost same level as at the beginning. The depression of gastric pouch secretion and its peptic activity after injection of the cancer extract, was more intensive and continued for longer time of period, compared to the cases injected with the extract of stomach wall. 3. These findings may partially depend upon the sudden change of the balance between water and electrolyte in blood, but the functional disturbance of gastric secretion cell by the cancer extract can be considered. 4. The experiment in vitro revealed the depressing action of cancer extract on peptic activity.
en-copyright=
kn-copyright=

en-aut-name=HayashiHiroshi
en-aut-sei=Hayashi
en-aut-mei=Hiroshi
kn-aut-name=林宏
kn-aut-sei=林
kn-aut-mei=宏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=3-2
article-no=
start-page=1267
end-page=1291
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590315
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of Ligature of Inferior Vena Cava Upon　Experimental Mitral Insufficiency
kn-title=実験的儈帽弁閉鎖不全症に対する下空静脈結紮術の効果について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A thorough understanding of the present concept of corrective surgery for mitral insufficiency substantiates the author's belief that it is an urgent technical challenge to secure the patients with advanced mitral insufficiency by balancing the increasing hazard of operative risk against the decreased and improved poor risk state as exists preoperatively. For this purpose, the author studied the effect of ligature of inferior vena cava upon experimental mitral insufficiency in dogs by means of hemodynamical, electrocardiographical and radiologic methods. Fifty dogs have been used in this experimental study. The following technical and patho-physiological innovations have been clarified: 1. The experimentally created mitral insufficiency utilizing the technique to cut the papillary tendons of posterior cusps relative widely revealed very similar hemodynamical patho-physiological patterns to human patients. 2. Marked improvement in decreasing the mortality has been found as follows: the mortality of dogs created experimental mitral insufficiency was 50 % and, in contrast to this, the mortality of dogs treated by ligature of inferior vena cava at the lower level of branching portion of renal veins was only 29.6 % . On the other hand, this ligature technique has been very effective to prevent the dog from immediate postoperative death or occurrence of acute and chronic pulmonary edema. 3. The hemodynamical pattern immediately after the ligature of vena cava upon experimental mitral insufficiency showed a marked improvement to restore more physiologic hemodynamics. Left atrial, pulmonary capillary and pulmonary arterial pressures increased by the creation of mitral insufficiency decreased markedly immediately after the ligature. This improved pattern is likely to be a precise reflection of decreased overloading of right ventricular system due to the decreased venous return into the heart. 4. The long durated postoperative observation on the same research also demonstrated the similar hemodynamical improvement as mentioned in item 3. Morever, the decreased pulmonary resistance seen in the postoperative observation indicated a marked hemodynamical improvement. These improved patterns durated at least one month latter after ligature. 5. In the electrocardiographic study, it has been thought to be most feasible to devide into two major diverse types of the experimental mitral insufficiency as follows: the first is high pressure group in which the left atrial pressure increased over 10 mmHg in mean pressure. The second diverse group is low pressure group with increased left atrial pressure lower than former. The temporary electrocardiographic improvement has been found in high pressure group showing the temporal shortening of the prolonged QT-ratio by ligature of inferior vena cava. Dogs with right ventricular strain used to fail to recover in long term observation. On the other hand, the low pressure group revealed the more definite electrocardiographic improvement durated about one month latter after ligature. The improved pattern has been, for examples, that increased P(Ⅱ) and P(Ⅲ) waves showed tendency to lower and prolonged QT-ratio showed tendency to shorten. 6. In the radiologic study, the author applied the left ventriculography to demonstrate mitral regurgitation, the left atriography and the simple radiography of the heart in anteriorpoesterior position. Results indicated that ligature of inferior vena cava has the reducing effect of the size of atrial chamber and heart in general. However, this has no influence on the degree of mitral regurgitation. Thus, it has been very clear that the ligature of vena cava improves the cardiac function definitely. 7. In view of the fact that these improved patterns demonstrated in above items and since it is a clear-cut fact that the patients with advanced mitral insufficiency uniformly require the clinical improvement of their clinical signs preoperatively, it would therefore seem to be very necessary to restore the patients utilizing the ligature of inferior vena cava by which improvements in hemodynamical and cardiac functional patterns have been demonstrated clearly in experimental mitral insufficiency.
en-copyright=
kn-copyright=

en-aut-name=TeramotoShigeru
en-aut-sei=Teramoto
en-aut-mei=Shigeru
kn-aut-name=寺本滋
kn-aut-sei=寺本
kn-aut-mei=滋
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部砂田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=9
article-no=
start-page=3381
end-page=3391
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Serum Protein in Alkylphosphate Poisoning Part Ⅰ. Serum Protein in Patients with Parathion Poisoning
kn-title=有機燐製剤中毒と血清蛋白 第一編 パラチオン中毒患者の血清蛋白像
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the aid of electrophoresis the author pursued serum protein in fifteen patients stricken with parathion poisoning that broke out in the summer from 1955 to 1957; and obtained the following results: 1. As for the pathological changes common to all an increase in serum total protein could be observed at the onset and this increase was mainly due to an increase in the albumin fraction. Consequently the A/G ratio is also increased. The severer the parathion poisoning the more marked is the increrase, suggesting that in all probability a stimulation of the parasympathetic nervous system by poisoning is responsible for it. 2. The decrease in the serum total protein, albumin fraction and A/G ratio 2-3 days after the onset seems to be due to the paralysis of the parasymathetic nervous system by a large dosage dosage of atropine administration. In contrast to this, PAM (pyridine-2-aldoxime methiodide), without inducing change in the serum protein but improving symptoms of poisoning, namely, restoring the balance of the autonomous nerves, brings the protein picture back to normal.
en-copyright=
kn-copyright=

en-aut-name=KurodaYuichi
en-aut-sei=Kuroda
en-aut-mei=Yuichi
kn-aut-name=黒田祐一
kn-aut-sei=黒田
kn-aut-mei=祐一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=2-2
article-no=
start-page=721
end-page=736
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=INJURY AND EDEMA OF THE TENDON
kn-title=腱の損傷とその浮腫に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Today the statistical study on the edema of the tendon still remains in a state which requires further exploration. Therefore, by using a Mitamura's Abderhalden Dryer and Torsion-Balance, the author studied periodical changes of various edemas evoked by inflicting injuries to tendons, muscles, and skin of rabbits, and obtained the following results: 1. Of the Achilles tendon and long digital flexor tendon sutured groups, the edema both in the silk-thread group of the former and in the stainless-wire group of the latter was found to have reached its maximum stage around the end of the second week after operation, and it disappeared about the end of the sixth week. However, the degree of the edema is higher in the silkthread group than in the stainless-wire group. These findings coincide with microscopic ones. The normal water content of the Achilles tendon is about equal to that of the long digital flexor tendon when the Achilles tendon is severed. 2. Even in the case of severing the Achilles tendon, the edema reaches its maximum around the end of the second week after operation, and it practically disappears about the end of the sixth week. Likewise in the microscopic findings, the cellular substances are most abundant in the second week, showing an irregular inter-fiber spaces. These agree fairly well with the results obtained by Nakura and Takechi. 3. Changes of the edema evoked by pinching of the Achilles tendon, femur muscle, and femur skin take a similar course. The edema caused by the pinching of the musele and skin occurs more rapidly than that by the pinching of the tendon, especially markedly up to 24 hours after operation. 4. In comparing the degrees of the edema, it is highest in the case of pinching the femur muscle, followed by the pinching of the Achilles tendon → in the Achilles tendon sutured with silk thread → the severed part of the Achilles tendon → in the long digital flexor tendon sutured with stainless wire, in the order mentioned.
en-copyright=
kn-copyright=

en-aut-name=HazakiToshihiko
en-aut-sei=Hazaki
en-aut-mei=Toshihiko
kn-aut-name=羽崎寿彦
kn-aut-sei=羽崎
kn-aut-mei=寿彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部整形外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=2006
cd-vols=
no-issue=2
article-no=
start-page=37
end-page=61
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=2006
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Topichood of the Philippine topic Revisited from a cross－linguistic perspective
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper reexamines the nature of the so－called topic in Philippine languages, specifically its topichood in Tagalog, from a cross－linguistic perspective by comparing it with that of prototypical topic in other languages such as Japanese. The study reveals that its topichood is remarkable in its non-occurrence rather than its occurrence in sentences. It is also shown that although it exhibits similarities with prototypical topic in discourse in terms of its actor-orientedness, they also exhibit significant differences. I argue that one of the difficulties in identifying the nature of the Philippine topic lies in the fact that its choice is made by the interaction ofits sentential and discourse topicality itself with an independent grammatical characteristics that penetrates into the grammar of Philippine languages in general, i.e. patient-orientedness, and the relational balance between these factors can be different depending on transitivity of verbs and the degree of grammaticalization among different Philippine languages.
en-copyright=
kn-copyright=

en-aut-name=KatagiriMasumi
en-aut-sei=Katagiri
en-aut-mei=Masumi
kn-aut-name=片桐真澄
kn-aut-sei=片桐
kn-aut-mei=真澄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=4
article-no=
start-page=1011
end-page=1022
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Gastric Ulcer Induced by Hormonal Disharmony Part 1. On the Influence of Some Changes in Blood Component Upon the Gastric Ulcer Induced by Adrenalectomy
kn-title=ホルモン失調性胃潰瘍の実験的研究 第1編 ホルモン失調性胃潰瘍と血液性変化との関係
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The relationship between the ulceration in the glandular stomach of rats, induced by adranalectomy, and the substitution therapy or the changes in blood components has been investigated. As agents for the substitution therapy after adranalectomy physiologic saline solution, cortisone and DOCA were used. During the substitution therapy, non-protein nitrogen in whole blood, protein and sodium-potagsium concentration in serum were determined. When the abnormality of sodium-potassium balance in the serum after adrenalectomy was corrected by the administration of physiologic saline solution or cortisone (0.1-0.15/mg/day/100g B.W.), ulceration could be prevented. However, when the excessive substitution therapy by cortisone (5 mg/bay/animal) was done, it was failed to prevent the induction of ulceration. When DOCA was used excessively and sodium-potassium balance in serum was under the state of disharmony, no ulceration was found. And it was recognized that the ulceration and the change in the none protein nitrogen or protein was not intimately correlated. Through these experiments, it has been, therefore, surmized that the gastric ulceration following adranalectomy was mainly influenced by the sort of substitution therapy, rather than by the alteration of certain specific factor in the blood components.
en-copyright=
kn-copyright=

en-aut-name=KondoHidemi
en-aut-sei=Kondo
en-aut-mei=Hidemi
kn-aut-name=近藤日出海
kn-aut-sei=近藤
kn-aut-mei=日出海
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=7-8
article-no=
start-page=619
end-page=635
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1967
dt-pub=19670830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Diencephalo-Pituitary Adrenocortical Functions and Role of Frontal Lobe to These Systems in Mental Diseases
kn-title=精神病者の間脳・下垂体・副腎皮質系機能及び前頭葉関与に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=As a link in the series of studies on the functions of the diencephalo-pituituitary adrenocortical system in endogenous psychosis, an investigation was carried out on 26 cases of schizophrenia who received the standard bilateral lobotomy, for the purpose to find out how the frontal lobe affects to the endocrine functions and autnomic nervous systems. For this purpose ACTH (25 units) was administered intramuscularly to 17 cases of them, and the m echolyltest was conducted with the other 9 cases, measuring the lelvels of corticoids in serum and urine of both groups. For the controls, ACTH was administered to 9 cases of schizophrenia who did not receive lobotomy. The results of the study may briefly be summarized as follows. 1) In the control group after ACTH adiministration the serum 17-OHCS showed a tendency of a decrease in the cortical reserve capacity, and in the lobotomized group there could be seen an abnormal reaction to ACTH in addition to a decrease in the cortical reserve capacity. 2) Total blood cholesterol after the ACTH stimulation decreased temporarily, showing similar changes up to 30 minutes in both groups, but in the lobotomized group an increase in cholesterol could be observed thereafter, revealing a contrasting phenomenon to the decreasing tendency of the serum 17-OHCS. 3) The blood potassium decreased transiently 10 minutes after the ACTH administration in both groups and such changes were unstable in the control group while the blood potassium in the lobotomized group increased steadily. As for the fluctuations of urine potassium its excretion was decreased transiently after the ACTH administration in both groups, which later rebounded, and this recovery tendency was more marked in the lobotomized group. 4) 17-KS excreted in urine on ACTH stimulation increased accompanying a marked increase in the amount of urine in the case of lobotomized group. 5) The results of the mecholyl test revealed that even the lobotomized patients respond to mecholyl, but there can be observed a decline and delay in the reactivity. 6) Observations on the fluctuations of serum 17-OHCS, urine 17-OHCS and 17-KS conducted simultaneouly with the mecholyl test revealed a declinining tendency in serum free 17-OHCS while total 17-OHCS in urine to be rather increased in the lobotomized group. The quantity of 17-KS excreted in urine decreased at first and then increased, and such a tendency did not parallel with the change in the total 17-OHCS excreted in urine. In the patients showing identically the same pathological conditions there could be recognized no distinct correlation between the type of response to mecholyl and the corticoid picture. 7) While we can recognize a certain correlation between defect symptoms of the frontal lobe and the endocrine functions, when we investigate individual caes, we find complex features in the endocrine function and autonomic nervous system according to the constitution before the lobotomy and the postoperative pathological picture. Namely, in those patients in a quiet mentbal state, though they are not completely cured, both functions maintain the balance in the state of lowered tension. On the other hand, in those who show a premonition of unrest and excitation, both functions have become unstable. Moreover, those who may have hallucination and delusion and are in the state of chronic defect, so long as there occurs no excitation, they show the levels of function close to the normal. 8) Summarizing these findings, it may be said that there is a decreasing tendency of the response to the ACTH stimulation in the functions of the diencephalo-pituitary-adrenocortical system of chronic shizophrenic group, and distribution of the estimated values is larger than that of normal persons, and this tendency is still more pronounced in the lobotomized group. Furthermore, the dissection of the frontal lobe brings about a defective equilibrium in the reaction mechanism of regulating center in endocrine system, but once placed under a strong stimulus, this balance is broken and there occurs a marked disruption in the endocrine rhythm.
en-copyright=
kn-copyright=

en-aut-name=IzumiyaKazunori
en-aut-sei=Izumiya
en-aut-mei=Kazunori
kn-aut-name=出宮一徳
kn-aut-sei=出宮
kn-aut-mei=一徳
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=7-8
article-no=
start-page=589
end-page=597
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1967
dt-pub=19670830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Electron Microscopic Study of Japanese Encephalitis VirusPart Ⅰ. A Study on the Ultrastructure of JE Virus
kn-title=日本脳炎ウイルスの電子顕微鏡的研究 第1編 日本脳炎ウイルス粒子の形態
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=An electron microscopic study was performed on the ultrastructure of the Mukai strain of Japanese encephalitis virus propagated in vitro on PS cells. PS cells were cultivated in bottles containing 10% calf serum and 0.5% lactalbumin hydrolysate in Earle's balanced solution. Titration of cell-associated virus was estimated by cytopathic effect. At various intervals following infection, the cells were fixed in buffered 1% osminum tetroxide-solution, embedded in methacrylates and cut on a Leitz ultramicrotome. After the sections were stained in saturated uranyl acetate solution, they were observed in the Hitachi type HUll electron microscope. It is suggested that the JE virus particle is hexogonal in shape and approximately 40 mu in the longest diameter, it is composed of an outer membrane 20 A° thick viroplasm 30 A° thick, and an electron dense nucleoid 25 mu in diameter.
en-copyright=
kn-copyright=

en-aut-name=MogurumaMasahito
en-aut-sei=Moguruma
en-aut-mei=Masahito
kn-aut-name=六車昌士
kn-aut-sei=六車
kn-aut-mei=昌士
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=82
cd-vols=
no-issue=7-8
article-no=
start-page=361
end-page=372
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1970
dt-pub=19700831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on acid base balance of the cerebrospinal fluid under acute intracranial hypertension
kn-title=急性頭蓋内圧亢進時の髄液酸塩基平衡に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author devised on pparatus for continuous monitoring of acid base balance of CSF without any CSF exposure to the atomosphere. The apparatus is an extracorporeal "ventriculo-cisternal circulation system" which is consisted of pressure pump, glass capillary electrode, Clark PO(2) eleotrode and Severinghaus Pco(2) electrode, all-lined up on a stainless steal conduit betweeen　lateral ventricle and cisterna magna. In the experimental cases of 5 dogs, the ventriculo-cisternal circulation system was used for monitoring acid base balanec of the CSF under acute intracranial hypertension produced by extradural balloon inflation. The blood Pco(2) was constantly watched during experiment to be kept in the normal range by means of a respirator. Pco(2) in the CSF began to increase in early stage above the pressure of CSF of 300 mmH(2)O and incseased more and more in parallel with raised pressure. HCO(3)- in the CSF was decreased when acute and more severe intracranial hypertension was maintained for hours. Hypercapnic acidosis and　metabolic acidosis occured in the CSF specifically when the intracranial pressure was raised acutely. Clinically, acid base balance of the CSF was studied on acute intracranial hypertension of three patients who suffered from brain tumor. Intracranial pressure was monitored continuously by pressure gauge transducer connected to the ventricular drainage. In this clinical research, CSF, arterial blood and jugular blood were sampled for measurement. Pco(2) in the CSF was increased　when the intracranial pressure was elevated above 500mmH(2)O and metabolic　acidosis was added when the pressure was more elevated continued. That is to say, CSF　became acidosis as same as experimental results. On the contrary, arterial　blood became respiratory alkalosis when the intracranial pressure was elevated　to 500-1000mmH(2)O. This phenomenon suggest that increse of hydrogenic ions induced by intracranial hypertension stimulates respiratory center. Hypercapnic acidosis and metabolic acidosis occur specifically in　the CSF independently from the change in the blood when the intracranial　pressure rises. Namely, the acid base balance of the CSF can not evaluated　from that of the blood. The author adovocates this state is hidden acidosis.
en-copyright=
kn-copyright=

en-aut-name=DoiAkihiro
en-aut-sei=Doi
en-aut-mei=Akihiro
kn-aut-name=土井章弘
kn-aut-sei=土井
kn-aut-mei=章弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳神経外科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=81
cd-vols=
no-issue=1-2
article-no=
start-page=17
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1969
dt-pub=19690228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental and Clinical Study on Prolonged Extracorporeal Circulation
kn-title=長時間体外循環の実験的,臨床的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Effects of prolonged extracorporeal circulation lasting four hours on acid-base balance were studied on dogs. Following results were obtained. 1) High flow perfusion is superior to low flow in all aspects. 2) Low molecular weight dextran is effective to prevent peripheral intravascular pooling of blood resulting in steady venous return, to maintain high flow rate and normal blood pressure, and also to inhibit increase in excess lactate. Dilution rate ranging from 15 to 25 per cent is pertinent. 3) Correction of pH with either sodium bicarbonate or Tris-buffer is preferable to compensation by respiratory alkalosis. 4) Survival time of the experimental animals can be prologed by blood replacement with fresh blood at the termination of the perfusion. However, no experimental animals survived the experiment. The same was studied on patients who underwent open heart surgery. All survived the operation and the results were as follows. 1) The metabolic changes are most prominent immediately after the perfusion and a tendency to recover appears 3 hours after the procedure. The return to normal condition is accomplished later than 5 hours after the perfusion. 2) Recovery of the various factors concerning with the acid-base balance (pH, pCO(2), baseexcess, lactids, excess lactate) is delayed proportionately to the prolongation of the perfusion time.
en-copyright=
kn-copyright=

en-aut-name=IwasaShigeo
en-aut-sei=Iwasa
en-aut-mei=Shigeo
kn-aut-name=岩浅茂夫
kn-aut-sei=岩浅
kn-aut-mei=茂夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部砂田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=83
cd-vols=
no-issue=3-4
article-no=
start-page=35
end-page=63
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1971
dt-pub=19710430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Acid-Bace Imbalance in Surgery
kn-title=外科領域における酸塩基平衡障害に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=It is obvious that in the field of surgery the management before and after operation has a grest influence on the survival of the patient. As a step in such management the acid-base balance is considered to have a great bearing on the homeostasis of the body. In view of this, the author measured the humoral pH of the patients for the period of one week before and after operation with Astrup's microequipment to determine various values of the acid-bese balance. Simultaneously, measurements were taken of the circulating blood volume and Ht values of the same individuals, and in some cases the contents of Na, K, CI, lactate and pyruvate in their serum and urine were estimated. As a result it was found that even in the case of acid-base imbalance postoperative metabolic acidosis has an important role in it. Especially low pH was observed in the cases of advanced age of 60 years, requiring more than 6 hours for operation of malignancy, and needing blood transfusion of over 1,000 cc, that is, the greater was the surgical intervention, the more severe was postoperative metabolic acidosis. The circulating blood volume decreased immediately after operation, and taking a course similar to the change in the acid-base balance, it returned to the preoperative level in one week. Ht value also served as a good criterion for the circulating blood volume. while the blood Na level declined after operation, the potassium and chloride levels showed no appreciable change. Lactate and pyruvate increased immmediately after operation, but they returned to the preoperative level within 3 days. Judging from these results, Lactate-Ringer solution was beter than 5% glucose solution for the transfusion during operation, especial effective was Lactate-Ringer solusion at pH 8.0 for the prevention of postoperative metabolic acidosis. In addition, from standpoint of mainten anee of the circulating blood volume, D40 Lactate-Ringer solution (Lactate-Ringer solution supplemented with low molecular Dextran) proved to be effective. For the treatment of this metabolic acidosis THAM (Trishydroxy-methylaminomethane) was effective as reported by various authors. The metabolic acidosis in 2 or 3 days was not so severe as to require any correction.
en-copyright=
kn-copyright=

en-aut-name=TabuchiSaburo
en-aut-sei=Tabuchi
en-aut-mei=Saburo
kn-aut-name=田渕三郎
kn-aut-sei=田渕
kn-aut-mei=三郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=3-4
article-no=
start-page=239
end-page=252
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The experimental study on the rapid massive intravenous administration of balanced electrolytes solution
kn-title=大量輸液に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ShimizuNobuyoshi
en-aut-sei=Shimizu
en-aut-mei=Nobuyoshi
kn-aut-name=清水信義
kn-aut-sei=清水
kn-aut-mei=信義
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=87
cd-vols=
no-issue=11-12
article-no=
start-page=1059
end-page=1074
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1975
dt-pub=19751230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of Electrolyte Metabolism During Extracorporeal Circulation
kn-title=体外循環時における電解質代謝の研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=It has been shown that changes of serum electrolyte have occurred during cardiopumonary bypass and that the changes have affected on prognosis of open heart surgery. This study was undertaken to reveal causes of the electrolyte changes and to minimize them. Clinical study was performed in 48 patients who underwent open heart surgery for either congenital or aquired heart disease. Experimental study was made using 30 healthy mongrel dogs and a main purpose of the experiment was to determine mutual changes of the electrolyte, including sodium, potassium and magnesium. when magnesium was added in the priming solution Heart-lung machine employed was disc oxygenator type (Pemco) or bubble oxygenator type (Junken), primed with hemodiluted solution (20%) under normothermia. The following results were obtained: -Clinical studies- 1) Serum potassium and magnesium levels decreased during perfusion, but potassium level of R. B. C. increased a little. Urinary excretion of potassium increased after perfusion. However, it started during perfusion in a group (group B) in whom digitalis, KCl and diuretic had been given before operation. Potassium of the serum and R. B. C. returned to the preperfusion level by the 1st post-op. day and magnesium level did by the 4th post-op. day, but in group B it returned after the 4th post-op. iday. 2) Hypokalemia during perfusion became severer as perfusion time was prolonged. 3) Open heart surgery resulted in metabolic acidosis but serum potassium level was not in correlation with serum PH. 4) Potassium and magnesium levels in the muscle decreased after perfusion, while sodium level increased. -Experimental studies- 1) Potassium and magnesium levels of the serum and R. B. C. decreased as well as in the clinical studies. 2) In the cerebrospinal fluid, however, potassium and magnesium levels were gradually risen during perfusion. 3) Potassium level of the striated muscle decreased during perfusion, but there was no change in potassium level. Potassium level of the liver remained unchanged. 4) Magnesium supplements during perfusion maintained electrolyte balance satisfactory, namely, urinary loss of potassium reduced and, therefore, hypokalemia was improved. It was concluded that magnesium supplements were recommended to be added to priming solution to improve potassium metabolism during and after extracorporeal circulation.
en-copyright=
kn-copyright=

en-aut-name=EbaraYoshio
en-aut-sei=Ebara
en-aut-mei=Yoshio
kn-aut-name=江原芳男
kn-aut-sei=江原
kn-aut-mei=芳男
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第2外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=87
cd-vols=
no-issue=5-6
article-no=
start-page=393
end-page=407
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1975
dt-pub=19750630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of total parenteral nutrition on body weight, nitrogen balance and various organs in the immediate post operative period in rats
kn-title=術後における完全静脈栄養の実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The experiment was undertaken to study the effect of total parenteral nutrition (TPN) on nitrogen balance and organs in the postoperative period, 73 of six-week old rats were devided into four groups as follows. Group Ⅰ Simple laparotomy and oral feeding Group Ⅱ Simple laparotomy and TPN Group Ⅲ Intestinal bypass operation and oral feeding Group Ⅳ Intestinal bypass operation and TPN TPN groups received 338 cal/kg/day and 1,96Ng/kg/day administered continuously throughout 13 days. The body weight increase in group Ⅰ, Ⅱ, Ⅲ, and Ⅳ were 66,6g, 55,6g, 4,6g and 42,5g, respectively. The weight gain was observed in TPN groups during postoperative period. The nitrogen balance study in group Ⅱ and Ⅳ showed that positive nitrogen balance was able to achieve in both group and cumulative nitrogen balance in group Ⅱ and Ⅳ was 1,65g and 1,31g, respectively. This study shows that positive nitrogen balance can be obtained in the immediate postoperative period by means of TPN. Small intestine during TPN showed significantly lesser in weight and shorter in villous height than that of oral feeding. The lack of absorption of nutrients from intestinal mucosa seems to be responsible. Histological studies of TPN group revealed that liver and spleen had fatty infiltration and there was swelling of reticuloendothelial cells which is supposed to be due to infusion of fat emulsion. Swollen cells of tubules in the kidney were observed.
en-copyright=
kn-copyright=

en-aut-name=SodaMitsuhiro
en-aut-sei=Soda
en-aut-mei=Mitsuhiro
kn-aut-name=曽田益弘
kn-aut-sei=曽田
kn-aut-mei=益弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部外科学第二教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=3-4
article-no=
start-page=421
end-page=444
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19780430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Study of the elemental diet -It's applecation to experimental short gut syndrome in the rats.-
kn-title=Elemental dietに関する実験的検討 ―とくに小腸曠置ラットに対する栄養的価値について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The first effort was made to document that elemental diet was satisfactory in maintaining normal growth in rats. A second effort was made to determine the maximum resectability of the intestine when rats were fed only by the elemental diet. These experiments were done in 80 ten-week-old female Wister rats. Results obtained are as follows (1) Eight rats fed only by the elemental diet through gastrostomy for 20 days gained more weight than pre-operative weight (P<0.02), and a positive nitrogen balance was obtained when rats were given with calories of 303 cal/kg/day and 8.25g/kg/day of amino acids. Also long term experiment of giving the elemental diet by mouth for 60 days resulted in increase of body weight (P<0.001), and there was no abnormality in hematological and pathological evaluations. (2) Body weight became heavier than that of before operation in the rats with 70% or 80% resection of the small intestine with P<0.001 and P<0.05, respectively. In the latter group, however, recovery from surgical assault were delayed, the pancreas and lung were often compromised and blood urea nitrogen as well as serum enzymes such as s-GOT and s-GPT were abnormally high. In 90% resection rats mortality was very high (85.7%). Therefore, it was concluded that the maximum resectality of the small intestine was 70% when rats were fed by elemental diet. (3) If the ileocecal valve was resected, pre-operative body weight was not resumed even in 70% -resection rats, indicating the importance of the valve. (4) When pyloroplasty was added in 70% -resection rats, gain in body weight was larger as compared with 70% resection group and non-resection group (P<0.005 and P<0.01, respectively). Abnormal findings in the liver, pancreas and lung were lesser and serum protein was elevated (P<0.001). These results show that elemental diet is effective tool of nutrition and exclusion of small intestine can be done safely as much as 70% However, improvement of administration and nutritional constitution may be able to endure much more extensive resection.
en-copyright=
kn-copyright=

en-aut-name=TakabatakeToshifumi
en-aut-sei=Takabatake
en-aut-mei=Toshifumi
kn-aut-name=高畠敏史
kn-aut-sei=高畠
kn-aut-mei=敏史
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=7-8
article-no=
start-page=757
end-page=780
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19770830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The effects of total parenteral nutrition on the histological and cytological changes of several organs in rats.
kn-title=完全静脈栄養法による各臓器の変化に関する組織学的,細胞学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The experiment was carried out to investigate the effects of total parenteral nutrition (TPN) on body weight, nitrogen balance and the histological or cytological changes of main organs in rats. TPN was introduced to 59 female Wistar rats of seven weeks after birth, for ten days. The animals were devided into six groups as follows: Group I Control, fed orally by pellets Group II TPN of amino acid-fat-glucose Group III TPN of amino acid-glucose Group IV Fat and glucose Group V Amino acid exclusively Group VI Starvation 1) The body weight increases in Group II and III were 6.7% and 3.6% of the initial value, respectively. However, the increase in body weight of each group was less than that of control. Nitrogen balance study showed that cumulative nitrogens of Group II and III for seven days were 1.10 and 0.93 grams, respectively. 2) Fatty infiltration in the liver was not due to whether TPN consisted of fat or not. When a Cal/N ratio was increased in TPN, liver showed fatty infiltration at the peripheral regions of the lobules. The fatty infiltration seemed to become more diffuse as caloric excess was greater. Electron microscopy of hepatocytes revealed multiple giant lipid droplets in cytoplasm and glycogen cluster localizing around lipid droplets. This suggests that glycogen may change to fat following TPN. 3) TPN caused an atrophy of exocrine pancreas. The atrophy was much greater in Group IV, which was excluded amino acid. Ultrastructurally, pancreatic acinar cells revealed increased FCD (focal cytoplasmic degradation) of various size, augumented flat mitochondria, increased immature zymogen granules and dilatation of rough surfaced endoplasmic reticulum. These results show that deprivation of amino acid from TPN causes impairment to pancreatic acinar cells, even in short period. 4) Infusion of hypertonic glucose or amino acid caused cloudy swelling and vacuolization of renal tubule epithelial cells, which ultrastructurally coincided with the swelling, deformity and vacuolization of mitochondria, low electron density of cytoplasm and increased lysosomes.
en-copyright=
kn-copyright=

en-aut-name=MizobuchiMasayuki
en-aut-sei=Mizobuchi
en-aut-mei=Masayuki
kn-aut-name=溝渕正行
kn-aut-sei=溝渕
kn-aut-mei=正行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部外科学第二教室
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=3-4
article-no=
start-page=253
end-page=272
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19770430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Phosphate balance during total parenteral nutrition in rabbits
kn-title=実験的高カロリー輸液時における無機リンの代謝
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Total parenteral nutrition (TPN) has induced a new complication of hypophosphatemia. This study was to real phosphate metabolism by determing nitrogen balance, phosphate balance and serum inorganic phosphate level in rabbits that had been maintained on TPN for 2 weeks. Results obtained are as follows. 1) It was necessary to supply 10-15 mEq/100 Cal of phosphate to maintain serum phosphate level within normal range. 2) Phosphate balance was negative even if phophate of 15 mEq/100 Cal was given when daily intake calories was subnormal. Therefore, to obtain positive balances of phosphate and nitrogen, fairly large supply of calories (about 93 Cal/kg/day) and phosphate (about 10 mEq/kg/day) was necessary. 3) To evaluate phosphate metabolism, it was necessary to be aware of phosphate balance, but also serum phosphate and 2, 3-DPG in erythrocyte. 4) It was also found that phosphate balance in TPN was under control by calorie intake and phosphate supply.
en-copyright=
kn-copyright=

en-aut-name=HiroseTsunemichi
en-aut-sei=Hirose
en-aut-mei=Tsunemichi
kn-aut-name=廣瀬正典
kn-aut-sei=廣瀬
kn-aut-mei=正典
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=11-12
article-no=
start-page=1665
end-page=1683
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19791230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Comparison of different amino acid solutions for total parenteral nutrition in rats
kn-title=静脈内栄養におけるアミノ酸の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The experiment was undertaken to determine the optimal amino acid solution for total parenteral nutrition (TPN) in 20 rats. Four different amino acid solutions were used, namely A, B, C and D, of which the E/N ratios were in order 0.8, 1.0, 2.0 and 3.0. TPN was introduced to rats of non-operated and operated groups, using these amino acids. Body weight change, nitrogen balance and plasma and urine aminograms were studied for assessment of the effect. The results were as follows; Non-operated group: Although all groups showed weight gain and positive nitrogen balance, group B with an E/N ratio of 1.0 was the best, followed by C, A then D. Blood aminograms showed markedly elevated levels of Thr in all groups, especially in B, C and D. This may be due to overdosage of Thr for rats. D group had increased urinary loss of Lys, Thr and Glu. These data suggest that B was the best amino acid solution for TPN in the non-operated group. Operated group: A small intestinal bypass operation was performed in rats and TPN was begun after operation. Weight gain and positive nitrogen balance were less than in the non-operated group. The best result was obtained in group C. Marked rise of Thr was observed as in the non-operated group. The typical pattern of postoperative change of aminogram was not seen, i.e., Phe, Met, branched amino acid did not increase. The aminogram of group C was close to the normal pattern. In the operated group, C with an E/N ratio of 2.0 was the optimal amino acid solution.
en-copyright=
kn-copyright=

en-aut-name=KobayashiTaihei
en-aut-sei=Kobayashi
en-aut-mei=Taihei
kn-aut-name=小林大平
kn-aut-sei=小林
kn-aut-mei=大平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2外科学教室
en-keyword=アミノ酸混合液
kn-keyword=アミノ酸混合液
en-keyword=E/N比
kn-keyword=E/N比
en-keyword=ラット
kn-keyword=ラット
en-keyword=完全静脈栄養
kn-keyword=完全静脈栄養
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=7-8
article-no=
start-page=977
end-page=995
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study of acute brain swelling under acute intracranial hypertension -Cerebral acid-base balance, gas metabolism and cerebral vasoparalysis-
kn-title=急性頭蓋内圧亢進時の脳腫脹に関する実験的研究 ―脳静脈血および髄液の酸塩基平衡とcerebral vasoparalysis―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Acid-base and gas parameters of CSF and sagittal sinus blood were examined to investigate the pathogenesis of acute brain swelling following elevation of ICP. Acute intracranial hypertension was produced in 26 adult mongrel dogs by means of unilateral epidural balloon inflation. ICP was monitored by a small epidural balloon connected to a pressure transducer and recorded by a strip recorder. Arterial blood pH, pCO(2) and pO(2) were measured every 10 min. during the course of the experiment, and were kept within normal range by artificial ventilation. Venous blood from the superior sagittal sinus and CSF from the cisterns magna were also sampled for pH, pCO(2) and pO(2) measurement. Cortical pH was measured using a microglass electrode placed on the brain surface. EEG was recorded in the bilateral frontoparietal cortical region. Changes of the ICP were recorded after 10% CO(2) inhalation in order to estimate CO(2) reactivity of the cerebral vessels under intracranial hypertension. Animals used were divided into two groups: Group A consisted of six animals in which the epidural balloon was inflated to 6 ml. resulting in increase of ICP to 50-100 mmHg. Group B included 20 animals in which the epidural balloon was inflated to the level where the so called Cushing's response was observed. In both groups, the balloon was abruptly deflated at the point where a desingated intracranial hypertension was obtained. In 9 out of 20 animals of Group B, ICP spontaneously increased again after deflation of the epidural balloon; this situation was called "acute brain swelling". In these animals with acute brain swelling, acid-base measurement revealed not only lowering of pH in cerebral venous blood, CSF and cerebral cortical surface, but also a significant increase in pCO(2) in both cerebral venous blood and CSF. Disappearance of CO(2) reactivity of cerebral vessels associated with isoelectric EEG was observed in these animals as well. On the other hand, acute brain swelling did not develop in the animals of Group A which did not lose CO(2) reactivity with EEG and remained normal. These animals showed no disorder of acid-base balance and gas metabolism in CSF and cerebral venous blood. In order to treat cerebral acidosis and hypercapnia in 9 animals which developed acute brain swelling, the alkalizing agent, tris hydroxy methyl amino methane (THAM) was administered and its beneficial effect on the acute brain swelling was examined. After drip infusion of 0.3 mole THAM (10 ml/kg), acidosis and hypercapnia of CSF and cerebral venous blood improved in 7 out of 9 animals. These results indicate that acute brain swelling following intracranial hypertension results from cerebral vasoparesis which is mainly caused by metabolic abnormalities such as cerebral acidosis and/or cerebral hypercapnia. Moreover it is suggested that THAM is an useful agent for combating acute brain swelling since it acts to restore cerebral vasomotor tone.
en-copyright=
kn-copyright=

en-aut-name=AkiokaTatsuro
en-aut-sei=Akioka
en-aut-mei=Tatsuro
kn-aut-name=秋岡達郎
kn-aut-sei=秋岡
kn-aut-mei=達郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳神経外科教室
en-keyword=急性頭蓋内圧亢進
kn-keyword=急性頭蓋内圧亢進
en-keyword=急性脳腫脹
kn-keyword=急性脳腫脹
en-keyword=cerebral vasoparalysis
kn-keyword=cerebral vasoparalysis
en-keyword=THAM
kn-keyword=THAM
END

start-ver=1.4
cd-journal=joma
no-vol=94
cd-vols=
no-issue=9-10
article-no=
start-page=853
end-page=875
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=19821030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of Total Parenteral Nutrition on Tumor Growth, and Plasma and Tumor Free Amino Acids in Tumor-bearing Rats
kn-title=担癌ラットにおける高カロリー輸液の腫瘍増殖,血漿および腫瘍組織アミノグラムにおよぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study was undertaken to reveal the effects of total parenteral nutrition (TPN) on tumor growth and plasma and tumor free amino acids in male Donryu rats having a transplanted Sato lung cancer. Animals were fed for 7 days and were divided into several groups as follows: 1. regular diet, 2. restricted regular diet, 3. protein free diet, 4.5 % glucose, 5. 21% glucose and 6 to 9. (TPN groups) 21 % glucose and different amino acids. Positive nitrogen balance was gained in TPN groups and body weight gain was observed except in a few cases. There was no stimulation in tumor growth by TPN, which was similar to the regular diet group. Plasma E/N ratio and percentage of blanched chain amino acids were decreased in malnourished rats, but E/N ratio and total amino acid concentration were increased in TPN and the amino acid pattern was similar to the regular diet group. In tumor amino acids analysis, there were no evident deviations of amino acid patterns from plasma amino acids. Constant amino acid trapping was revealed in tumor tissues. Amino acid imbalance therapy was suggested to be effective in the case of deficiencies of Tyr. Glu. and Asp. and high concentration of BCAA.
en-copyright=
kn-copyright=

en-aut-name=UjihiraKatsumi
en-aut-sei=Ujihira
en-aut-mei=Katsumi
kn-aut-name=氏平勝三
kn-aut-sei=氏平
kn-aut-mei=勝三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2外科学教室
en-keyword=高カロリー輸液 (Total parenteral nutrition)
kn-keyword=高カロリー輸液 (Total parenteral nutrition)
en-keyword=腫瘍増殖 (Tumor and Nutrition)
kn-keyword=腫瘍増殖 (Tumor and Nutrition)
en-keyword=血漿アミノ酸分析 (Plasma free amino acid)
kn-keyword=血漿アミノ酸分析 (Plasma free amino acid)
en-keyword=腫瘍アミノ酸分析 (Tumor free amino acid)
kn-keyword=腫瘍アミノ酸分析 (Tumor free amino acid)
en-keyword=アミノ酸インパランス (Amino acid imbalance)
kn-keyword=アミノ酸インパランス (Amino acid imbalance)
END

start-ver=1.4
cd-journal=joma
no-vol=94
cd-vols=
no-issue=9-10
article-no=
start-page=791
end-page=804
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=19821030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of total parental nutrition on body weight, tumor growth, plasma aminogram, tumor aminogram, nitrogen balance and histological finding in tumor bearing rats
kn-title=高カロリー輸液の癌治療への応用に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study was undertaken to examine the effect of parenteral nutrition upon body weight, tumor growth, plasma aminogram, tumor aminogram, nitrogen balance and histological change in rats with a transplanted tumor. Twenty-five male Donryu rats, having a subcutaneously transplanted Sato Lung Cancer were studied. They were divided into 5 groups. A silastic catheter was inserted into the superior vena cava via the left common jugular vein of rats of the infused group. Infusion continued for 7 days. Tumor size was three-dimensionally measured. All rats were sacrificed on the 8th day. The body weght increase in group I., Ⅱ., Ⅲ., Ⅳ and Ⅴ was 35.0g, 35.4g, -69.0g, 2.8g and -19.8g. The tumor growth rate in group I. Ⅱ. Ⅲ. Ⅳ and Ⅴ was 10.06, 4.15, 10.07, 8.01 and 4.75 respectively. Plasma aminogram showed markedly elevated levels of Thr in group Ⅳ, Ⅴ and Ser, Gly, Lvs, in group Ⅲ. On the contrary, lower levels of Val, Leu, Ile were found in group Ⅲ. ACNU had no effect on plasma aminogram. There was no difference between TPN and oral feeding as far as tumor aminogram was concerned. The nitrogen balance study in group Ⅲ revealed massive necrosis and small sized tumor cells. Tumor cells of group Ⅳ showed large multinclear cells and distinct chromatin. There was no significant difference between group Ⅱ and Ⅴ as far as anti-neoplastic effect of ACNU. Provision of adequate nutrition intravenously to tumor-bearing animals restores body weght and positive nitrogen balance. TPN has significant effect on intensive neoplastic therapy.
en-copyright=
kn-copyright=

en-aut-name=OhnishiMasataka
en-aut-sei=Ohnishi
en-aut-mei=Masataka
kn-aut-name=大西正高
kn-aut-sei=大西
kn-aut-mei=正高
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2外科学教室
en-keyword=完全静脈栄養
kn-keyword=完全静脈栄養
en-keyword=担癌ラット
kn-keyword=担癌ラット
en-keyword=ＡＣＮＵ
kn-keyword=ＡＣＮＵ
END

start-ver=1.4
cd-journal=joma
no-vol=91
cd-vols=
no-issue=3-4
article-no=
start-page=335
end-page=353
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Magnesium metabolism during total parenteral nutrition in rabbits
kn-title=完全静脈栄養におけるMg代謝に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Magnesium metabolism was studied during total parenteral nutrition (TPN) in rabbit. Rabbits were fed for 14 to 17 days by TPN of 110 Cal/kg/day with different doses of magnesium. Results were as follws: 1. Excretion of magnesium during starvation was 1.5 mEq/kg/day. The urinary Mg/N excretion ratio was 3.4 mEq/Ng. 2. An intake of 2.5 mEq/kg/day of magnesium was required to maintain normal plasma and erythrocyte magnesium levels, plasma P and Ca should be supplied at the rate of 9 mEq/kg/day (8.2 mEq/100Cal) and 1 mEq/kg/day respectively. 3. The excretion of magnesium, phosphorus and potassium increased during low calorie parenteral nutrition. 4. Although no depletion of nitrogen balance and body weight occurred during TPN with-out magnesium, impairment of K, P and Ca utilization was suspected. 5. This study of magnesium balance showed that magnesium may be required at early stages of TPN. 6. Magnesium deficiency was diagnosed by a fall in the levels of plasma magnesium, erythrocyte magnesium, and urinary magnesium excretion. This experiment indicates that TPN which includes quantities of magnesium may be needed for the metabolism of K, P and Ca.
en-copyright=
kn-copyright=

en-aut-name=NoguchiAtsushi
en-aut-sei=Noguchi
en-aut-mei=Atsushi
kn-aut-name=野口敦
kn-aut-sei=野口
kn-aut-mei=敦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=Mg代謝
kn-keyword=Mg代謝
en-keyword=完全静脈栄養
kn-keyword=完全静脈栄養
en-keyword=nitrogen balance
kn-keyword=nitrogen balance
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=小児における咬合機能と身体平衡機能の関連性に関する研究
kn-title=The relationship between functions of body balance and occlusion in childhood
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=DuXiaopei
en-aut-sei=Du
en-aut-mei=Xiaopei
kn-aut-name=杜小沛
kn-aut-sei=杜
kn-aut-mei=小沛
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=96
cd-vols=
no-issue=9-10
article-no=
start-page=991
end-page=1001
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=19841030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of fat emulsion given to rats immediately after an operation
kn-title=術直後の高カロリー輸液における脂肪代謝の実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This experiment was undertaken to clarify the effect of fat emulsion administered immediately after an operation. Total parenteral nutrition (TPN) was supplied to rats after partial resection of the small intestine. Animals were divided in two groups according to the TPN regimen: TPN without fat (TPN-G) and TPN with 30% of the non-protein calories provided by fat emulsion (TPN-F). TPN-F and TPN-G showed similar effects on body weight and nitrogen balance. The fat emulsion did not cause deleterious effects. Fat content of the liver was increased at 3 POD in both groups. The increase was attributable to triglycerides. Liver and muscle glycogen rose at 3 POD and returned to preoperative values at 5 POD. The results show that fat emulsion providing 30% of the non-protein calories is utilized as well as glucose in the immediate postoperative period.
en-copyright=
kn-copyright=

en-aut-name=HayashiMasakiyo
en-aut-sei=Hayashi
en-aut-mei=Masakiyo
kn-aut-name=林政清
kn-aut-sei=林
kn-aut-mei=政清
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2外科教室
en-keyword=高カロリー輸液
kn-keyword=高カロリー輸液
en-keyword=手術侵襲
kn-keyword=手術侵襲
en-keyword=脂質代謝
kn-keyword=脂質代謝
END

start-ver=1.4
cd-journal=joma
no-vol=96
cd-vols=
no-issue=5-6
article-no=
start-page=651
end-page=663
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=19840430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on some factors involved in the organization of a health insurance scheme -especially the factors influencing the financial balance-
kn-title=医療保険の成立要因に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Japan's medical expenditure has been growing rapidly year by year, and the rate of the national subsidy has inevitably been rising too. This has consequently become an urgent financial problem for the Government along with the Pension problem. Linked to this, there is also the bad financial state of the Society-managed Health Insurance Scheme, which is one of the main health insurance schemes in Japan, along with the Government-managed Health Insurance Scheme and the National Health Insurance Scheme, and which had been financially better-managed than the others. In this study, the author examined the factors influencing the financial balance of 1570 societies in this scheme from 1974 to 1981, by analyzing 20 of 213 items obtained from the report on striking a financial balance. The results are summarized as follows: (1) 'The ordinary financial balance of each society' is influenced by both 'the type of enterprise' and 'the type of society', with the former more influential than the latter. (2) Among societies, there are greater differences of factors, such as 'the sex ratio of insured persons', 'the total costs for health and welfare facilities', 'the ratio of costs for health education', 'the ratio of costs for preventive measures', 'the ratio of costs for promotion of sports', 'the costs for additional benefits per one insured person', 'the costs for additional benefits per one dependant', 'the total costs for benefits per capita', than other factors, when the author compares them. (3) From the result of the correlation analysis among the factors, 'the mean age of insured persons' shows a high correlation not only with 'the ordinary financial balance of each society' but also with many other factors. 'The total costs for health and welfare facilities' does not directly reflect the health care activity of each society. (4) 'The number of insured persons' has not directly influenced 'the ordinary financial balance of each society' but shows the financial stability of the society among the special type of society. (5) To show the synthetical character of each society, such factors as 'the average monthly standard remuneration', 'the type of enterprise', 'the type of society' and 'the number of insured persons' are adequate in respect of the total financial balance. In the same way, 'the total costs for benefits per capita', 'the number of insured persons' and 'the costs for additional benefits per one dependant' are adequate in respect of expenditure.(6) In excluding the confounding factors in the analysis, it can be seen that 'the average monthly standard remuneration', 'the mean age of insured persons' and 'the number of dependants per one insured person' have a significant influence on 'the ordinary financial balance of each society'.
en-copyright=
kn-copyright=

en-aut-name=TaniguchiTakashi
en-aut-sei=Taniguchi
en-aut-mei=Takashi
kn-aut-name=谷口隆
kn-aut-sei=谷口
kn-aut-mei=隆
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
en-keyword=医療保険
kn-keyword=医療保険
en-keyword=組合健康保険
kn-keyword=組合健康保険
en-keyword=経常収支
kn-keyword=経常収支
en-keyword=保健施設活動
kn-keyword=保健施設活動
en-keyword=医療給付
kn-keyword=医療給付
END

start-ver=1.4
cd-journal=joma
no-vol=95
cd-vols=
no-issue=11-12
article-no=
start-page=1281
end-page=1297
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1983
dt-pub=19831230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Late Component of Contingent Negative Variation (CNV) and Reaction Time (RT) in Hyperkinetic Children
kn-title=多動症候群におけるCNV後期成分と反応時間の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to clarify the electrophysiological aspects of the hyperkinetic syndrome, the late component of CNV (CNV immediately before S(2) for 200 msec) and reaction time (RT) were measured in 15 patients with hyperkinetic syndrome, 15 patients with emotional disturbance, and 30 normal children, all 7-12years old. In the normal children the late component of CNV increased in amplitude, while RT was shortened, as the age increased. The late component of CNV was considered to attain a level comparable to that of adults by the age of approximately 9 years. Only in the cases of hyperkinetic syndrome was the late component of CNV significantly low in amplitude. As to RT, however, no significant difference was observed among the three groups. In the hyperkinetic children, significant correlation was observed neither between IQ and the late component of CNV, nor between the normal and abnormal EEG groups and the late component of CNV and RT. Comparing responders with nonresponders to methylphenidate, it was found that the late component of CNV of the responders was significantly lower in amplitude than that of the nonresponders, but no such difference in RT was observed. In the two cases of hyperkinetic syndrome, methylphenidate was effective in increasing the amplitude of the late component of CNV. Concerning the hyperkinetic syndrome, the present findings were discussed in relation to the functional balance of midbrain reticular formation and the thalamus, and to the possible application of the late component of CNV to the clinical fields.
en-copyright=
kn-copyright=

en-aut-name=SasakiTakanobu
en-aut-sei=Sasaki
en-aut-mei=Takanobu
kn-aut-name=佐々木高伸
kn-aut-sei=佐々木
kn-aut-mei=高伸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
en-keyword=隋伴陰性変動
kn-keyword=隋伴陰性変動
en-keyword=反応時間
kn-keyword=反応時間
en-keyword=小児多動症候群
kn-keyword=小児多動症候群
en-keyword=情緒障害児
kn-keyword=情緒障害児
END

start-ver=1.4
cd-journal=joma
no-vol=96
cd-vols=
no-issue=5-6
article-no=
start-page=519
end-page=525
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=19840430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Study on the role of catalase for uptake of metallic mercuryPart 5 Exhalation of metallic mercury from acatalasemic and normal mice intraperitoneally injected with mercuric ion, and the mercuric uptake by acatalasemic and normal mice exposed to metallic mercury vapor
kn-title=金属水銀の取り込みに対するカタラーゼの役割に関する研究 第5報 アカタラセミアマウス及びノーマルマウス呼気中の金属水銀量及び金属水銀曝露時の水銀イオンの臓器分布
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Exhalation of metallic mercury from acatalasemic and normal mice intraperitoneally injected with mercuric ion ((203)HgCl(2)) and the mercury uptake by acatalasemic and normal mice exposed to metallic mercury vapor ((203)Hg(0)) were investigated. Exhalation of metallic mercury from acatalasemic mice injected with mercuric ion was higher than that from normal mice. The mercury uptake by normal mice exposed to metallic mercury was higher than that by acatalasemic mice. The liver and brain of acatalasemic mice were higher in the content than those of normal mice. On the other hand, mercury content in heart, lungs, blood and kidneys of acatalasemic mice was lower than in normal mice. The brain/blood concentration ratio of acatalasemic mice was higher than in normal mice. The distribution of mercury in the organs of acatalasemic mice injected with mercuric ion were similar to those of normal mice. Those results indicate that actalase has an important role in the uptake of metallic mercury, and the balance of reduction and oxidation systems influence the metabolism of mercury.
en-copyright=
kn-copyright=

en-aut-name=KenmotsuKatashi
en-aut-sei=Kenmotsu
en-aut-mei=Katashi
kn-aut-name=劒持堅志
kn-aut-sei=劒持
kn-aut-mei=堅志
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=rebuction of mercuric ion
kn-keyword=rebuction of mercuric ion
en-keyword=oxidation of metallic mercury
kn-keyword=oxidation of metallic mercury
en-keyword=acatalasemia mice
kn-keyword=acatalasemia mice
en-keyword=catalase
kn-keyword=catalase
en-keyword=exhalation of metallic mercury
kn-keyword=exhalation of metallic mercury
END

start-ver=1.4
cd-journal=joma
no-vol=96
cd-vols=
no-issue=5-6
article-no=
start-page=511
end-page=517
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=19840430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Study on the role of catalase for uptake of metallic mercury Part 4 In vitro reduction of mercuric ion by superoxide anion, NADPH, NADH and acatalasemic mouse liver homogenate
kn-title=金属水銀の取り込みに対するカタラーゼの役割に関する研究 第4報 スーパーオキサイドアニオン,NADPH,NADH及びアカタラセミアマウス肝ホモジネートによる水銀イオンの還元
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In vitro reduction of mercuric ion to metallic mercury by superoxide anion, NADPH, NADH and acatalasemic mouse liver homogenate was investigated. Superoxide anion generated by the xanthine-xanthine oxidase system reduced mercuric ion to metallic mercury in vitro. The reduction rate was inceresed linearly by the increasing concentration of xanthine oxidase. The reduction of mercuric ion by superoxide anion was increased by the addition of cytochrome c and nitro blue tetrazolium. The reduction of mercuric ion was inhibited in the presence of superoxide dismutase and catalase. The rate of reduction of mercuric ion by acatalasemic mouse liver homogenates was higher than that by normal mice liver homogenate. The reduction of mercuric ion by mouse liver homogenate was inhibited by the generation of superoxide anion, but the reduction rate by acatalasemic mouse liver homogenate was higher than that of normal mouse homogenate. NADPH and NADH reduced mercuric ion to metallic mercury. The reduction decreased in the presence of mouse liver homogenate. These results indicate that metabolism of mercury is influenced by the balance of oxidation and reduction systems
en-copyright=
kn-copyright=

en-aut-name=KenmotsuKatashi
en-aut-sei=Kenmotsu
en-aut-mei=Katashi
kn-aut-name=劒持堅志
kn-aut-sei=劒持
kn-aut-mei=堅志
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=reduction of mercuric ion
kn-keyword=reduction of mercuric ion
en-keyword=superoxide anion
kn-keyword=superoxide anion
en-keyword=NADPH
kn-keyword=NADPH
en-keyword=NADH
kn-keyword=NADH
en-keyword=catalase
kn-keyword=catalase
END

start-ver=1.4
cd-journal=joma
no-vol=100
cd-vols=
no-issue=11-12
article-no=
start-page=1089
end-page=1093
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1988
dt-pub=1988
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Findings of I-123 IMP, Tc-99m PAO SPECT and CT in a patient with progressive supranuclear palsy
kn-title=進行性核上性麻痺の1例-(123)I-IMP, (99m)TC・PAO, CT所見を中心として
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 60-year-old man was diagnosed as having progressive supranuclear palsy on the basis of his clinical symptoms of disturbance of balance and gait with unexpected falls, masking of the face, reduction is the volume of the voice and ophthalmoplegia. I-123 IMP, Tc-99m PAO SPECT and CT were performed. The CT examination showed atrophy of the midbrain, inter-brain and pons. SPECT studies revealed severe hypoperfusion bilaterally in the frontal cortex. These SPECT findings correspond to the report of frontal cortex hypometabolism detected by position tomography in patients with progressive supranuclear palsy (Brain 1985, 108, 785-799).
en-copyright=
kn-copyright=

en-aut-name=TanabeMasatada
en-aut-sei=Tanabe
en-aut-mei=Masatada
kn-aut-name=田邉正忠
kn-aut-sei=田邉
kn-aut-mei=正忠
aut-affil-num=1
ORCID=

en-aut-name=MatsunoShinsuke
en-aut-sei=Matsuno
en-aut-mei=Shinsuke
kn-aut-name=松野慎介
kn-aut-sei=松野
kn-aut-mei=慎介
aut-affil-num=2
ORCID=

en-aut-name=TamaiToyosato
en-aut-sei=Tamai
en-aut-mei=Toyosato
kn-aut-name=玉井豊理
kn-aut-sei=玉井
kn-aut-mei=豊理
aut-affil-num=3
ORCID=

en-aut-name=YamamotoMitsutoshi
en-aut-sei=Yamamoto
en-aut-mei=Mitsutoshi
kn-aut-name=山本光利
kn-aut-sei=山本
kn-aut-mei=光利
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=2
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=3
en-affil=
kn-affil=香川医科大学放射線医学教室

affil-num=4
en-affil=
kn-affil=香川県立中央病院 神経内科
en-keyword=進行性核上性麻痺
kn-keyword=進行性核上性麻痺
en-keyword=(123)I-IMP
kn-keyword=(123)I-IMP
en-keyword=(99m)Tc-HM･PAO
kn-keyword=(99m)Tc-HM･PAO
en-keyword=CT
kn-keyword=CT
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=2
article-no=
start-page=55
end-page=76
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090910
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Report on Survey for Work-Life Balance in Japanese Companies.
kn-title=企業のワーク・ライフ・バランスに関するアンケート調査（本調査）の報告
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MatsudaYoichi
en-aut-sei=Matsuda
en-aut-mei=Yoichi
kn-aut-name=松田陽一
kn-aut-sei=松田
kn-aut-mei=陽一
aut-affil-num=1
ORCID=

en-aut-name=KokumaiMitsuyuki
en-aut-sei=Kokumai
en-aut-mei=Mitsuyuki
kn-aut-name=國米充之
kn-aut-sei=國米
kn-aut-mei=充之
aut-affil-num=2
ORCID=

en-aut-name=WangJing
en-aut-sei=Wang
en-aut-mei=Jing
kn-aut-name=王静
kn-aut-sei=王
kn-aut-mei=静
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=2
article-no=
start-page=1
end-page=20
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090910
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Were Privileges and Restrictions given to Japanese Postal Savings as a Government Enterprise balanced in the 10 years before Privatization?
kn-title=官業の特典と制約はバランスしていたか？－郵便貯金民営化前１０年間について－
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The reason why public financial institutions that should tightly regulated have great power and oppress the private sector, which has been significantly deregulated in recent years, is often thought to be that so many privileges are given to public financial institutions as government enterprises. Indeed, we agree that government enterprises have had privileges, but if total size of them is smaller than that of their restrictions as government enterprises, it is difficult to say that they are the main cause of competitive dominance of government enterprises. Nishigaki (2009a) re−estimated sizes of privileges given to Japanese Postal Savings in the 10 years before privatization (1997FY-2006FY), and found that the size as to the accumulated amount of the 10 years was considerably smaller than that in the method of Japanese Bankers Association (2002, 2004), to which Yamori and Nishigaki (2004) had pointed its irrationality and great possibility of overvaluation. This paper firstly estimates sizes of restrictions (such as universal service obligations, social contribution activities, and opportunity costs caused by regulations of investments and businesses) given to Japanese Postal Savings in the same term, and secondly compares the total size with that of privileges in time−series. We will find the facts that, in the first half of the period, the privileges and the restrictions were almost balanced, so that in this regard no evidence can be confirmed that Postal Savings should have been oppressing private banks in Japan, and in the latter half (age of Japan Post), the balance came to be collapsed because of the large reduction of the privileges and of the rapid increase of the opportunity costs, as a result, its social contribution activities had to be reduced sharply.
en-copyright=
kn-copyright=

en-aut-name=NishigakiNarunto
en-aut-sei=Nishigaki
en-aut-mei=Narunto
kn-aut-name=西垣鳴人
kn-aut-sei=西垣
kn-aut-mei=鳴人
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=99
cd-vols=
no-issue=11-12
article-no=
start-page=1573
end-page=1587
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1987
dt-pub=19871230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental and electron microscopic study of atrial specific granules
kn-title=心房筋の特殊顆粒に関する実験的・電子顕微鏡的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The sodium and water balance of rats was varied, and changes in the number and distribution of specific atrial granules (ASG) were observed electron microscopically. The number of ASG in atrial muscle cells increased in rats without salt intake for 7-8 days. On the contrary, the number of ASG began to decrease 10 days after rats were given 2-2.5% sodium chloride solution ad libitum instead of water. After 30 days, the number of ASG decreased markedly in the central sarcoplasmic core, in the sarcoplasmic layer and under the cell membrane. Most atrial muscle cells in rats 6 days after hypophysectomy contained less ASG than those of control rats, and 30 days after the hypophysectomy, only a small number of ASG were observed in the central sarcoplasmic core, in the sarcoplasmic layer and under the cell mumbrane. The number of ASG increased the first 5 days after adrenalectomy, but did not change after 7 days. The number of ASG increased a little 4 weeks after birth in spontaneous hypertensive rats (SHR). ASG increased up to 20 weeks after birth of SHR, concomitantly with an increase in the blood pressure. To study the mode of secretion of ASG in detail, Ca-ionophore A23187 was used. In ionophore-treated cells, exocytotic figures were clearly demonstrated.
en-copyright=
kn-copyright=

en-aut-name=TobitaRyouichi
en-aut-sei=Tobita
en-aut-mei=Ryouichi
kn-aut-name=飛田領一
kn-aut-sei=飛田
kn-aut-mei=領一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一解剖学教室
en-keyword=心房筋特殊顆粒
kn-keyword=心房筋特殊顆粒
en-keyword=ナトリウム・水分代謝
kn-keyword=ナトリウム・水分代謝
en-keyword=下垂体・副腎摘出
kn-keyword=下垂体・副腎摘出
en-keyword=高血圧自然発症ラット
kn-keyword=高血圧自然発症ラット
en-keyword=分泌形態
kn-keyword=分泌形態
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=1
article-no=
start-page=17
end-page=30
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Computer Program of Assembly Line Balancing Considering the Performance Rate of Each Work Station
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Assembly line balancing is to assign work elements to serial work stations so as to make the work content at each station as close as possible to one limiting cycle time or pitch time, i.e., an upper time limit over every station. Until now, it is usually assumed that the
performance rates of work stations are constant. But in
practice the performance abilities of workers, machines or robots are varied by their own working conditions. Then the actual station times are different from standard ones, and consequently the line balance may diminish in many cases. Therefore in this paper, we propose an improved
balancing method, in which work elements can be assigned to the work station having the upper time limit changed by its performance rate or ability. Further we develop the computer program of the proposed method and provide an illustrative problem and computational results. In an application of our method to the practical problems, it is shown that the actual efficiency of the production line becomes near that planned.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=AkagiFumio
kn-aut-sei=Akagi
kn-aut-mei=Fumio
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=OsakiHirokazu
kn-aut-sei=Osaki
kn-aut-mei=Hirokazu
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Industrial Science

affil-num=2
en-affil=
kn-affil=Department of Industrial Science
END

start-ver=1.4
cd-journal=joma
no-vol=17
cd-vols=
no-issue=2
article-no=
start-page=15
end-page=29
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1983
dt-pub=19830630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Transmission Distance and Bit Rate in an Optical-Fiber Multi-Level PCM Transmission System
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Optical-fiber multi-level PCM transmission system is
investigated on the transmission distance and bit rate. A communication channel is established as follows: a light signal is modulated in intensity with a completely-balanced M-Ievel code at a transmitter, and is propagated over an optical glass fiber, and is demodulated at a receiver where the signal with an additive noise is processed through a PD, an equalizing amplifier, a matched filter, (M-l) comparators and a decision circuit. The relative power of the noise from the amplifier is increased in accordance with the reciprocal of fiber's transmittance, where shot noise and thermal noise are smoothed and decreased in power by the matched filter. The relation between the BER and the SNR leads the transmission distance. The product of the transmission distance and bit rate takes the large maximum at the large values of SNR and M. The large value of M is suitable for low-speed and high-rate system, and the interference system.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=TanadaYoshihiro
kn-aut-sei=Tanada
kn-aut-mei=Yoshihiro
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=SanoHiroya
kn-aut-sei=Sano
kn-aut-mei=Hiroya
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=XuHai
kn-aut-sei=Xu
kn-aut-mei=Hai
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electronics

affil-num=2
en-affil=
kn-affil=Department of Electronics

affil-num=3
en-affil=
kn-affil=Northeastern Normal University
END

start-ver=1.4
cd-journal=joma
no-vol=17
cd-vols=
no-issue=1
article-no=
start-page=15
end-page=40
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1983
dt-pub=19830225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Analysis of Three-Phase Thyristor Phase Control Circuit with Series RLC Elements
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=An ac phase control circuit by thyristor is widely used in industry, The characteristics of the singlephase circuit with series RLC elements are numerically analyzed, and is reported the interesting phenomenon of step-up voltage without transformer. However, the performance of three phase phase control circuit with series RLC elements is not made clear. In this paper, the performance of three-phase
control circuit of a balanced and an unbalanced load with series RLC elements is described. The analytical programs with each load are developed, and it is clarified that the calculated by this analytical program agree well with the measured. The calculated results, e.g. waveforms, RMS values of voltage and current, power, and power factor are illustrated and discussed the step-up phenomenon in three phase.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=HimeiToyoji
kn-aut-sei=Himei
kn-aut-mei=Toyoji
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NakanishiSen-ichiro
kn-aut-sei=Nakanishi
kn-aut-mei=Sen-ichiro
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=FunabikiShigeyuki
kn-aut-sei=Funabiki
kn-aut-mei=Shigeyuki
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=KomatsubaraHitoshi
kn-aut-sei=Komatsubara
kn-aut-mei=Hitoshi
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=KuroseOsamu
kn-aut-sei=Kurose
kn-aut-mei=Osamu
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=2
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=3
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=4
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=5
en-affil=
kn-affil=Graduate School of Electrical Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=2
article-no=
start-page=21
end-page=28
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19810330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Computer Program of Line Balancing under the Multiple Workers in Each Station (LBMW)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=An assembly line with no paralleling of work elements and work stations is called a serial line. The cycle time of the serial line must be at least equal to the maximum work element time. To lower the cycle time beyond the limit and increase the production rate, one may permit the paralleling of work elements or work stations. So in this paper we propose the parallel assignment method for achieving a higher production rate. In this method, work elements are assigned to work stations under the multiple upper time limits which are the products of the various numbers of workers and the limiting cycle time. Further we develop the computer program of the proposed method and provide an illustrative problem and computational results.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=AkagiFumio
kn-aut-sei=Akagi
kn-aut-mei=Fumio
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=OsakiHirokazu
kn-aut-sei=Osaki
kn-aut-mei=Hirokazu
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=KikuchiSusumu
kn-aut-sei=Kikuchi
kn-aut-mei=Susumu
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Industrial Science

affil-num=2
en-affil=
kn-affil=Department of Industrial Science

affil-num=3
en-affil=
kn-affil=Department of Industrial Science
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=
article-no=
start-page=83
end-page=93
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790305
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Computer Program of Line Balancing, Regarding Efficiency and Number of Stations as Variables
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To assign work elements to the work stations in an assembly or manufacturing line, various computer programs have been developed and used. And it does that the number of stations or the cycle time is even given. But in practice it is desirable to obtain the assignment which shows the highest efficiency of line balancing under all possible combinations of the number of stations and the cycle time. Therefore we propose a computer program of the assignment method in which the efficiency of line balancing, Ebb and the number of stations, NN are regarded as variables. In this method the minimum value (EEb) of efficiency and the constant term (d) by which Ebb is reduced are given previously. And for any COmbination of Ebb (EE<Ebb<lOO) and NN (l<NN<Nm : Nm calculated from EEb), the work elements are assigned to work stations, the precedence restrictions being used. Ebb is reduced by d from the ideal value (100) until the assignment to NN is obtained. The efficiency of
the obtained assignment, Ebo is calculated. As Ebb<Ebo<Ebb+d, the calculation is continued until the assignment to NN, which shows the maximum efficiency, is obtained. In this process NN varies from Nm to 1 by 1 by 1.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=AkagiFumio
kn-aut-sei=Akagi
kn-aut-mei=Fumio
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=OsakiHirokazu
kn-aut-sei=Osaki
kn-aut-mei=Hirokazu
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=KikuchiSusumu
kn-aut-sei=Kikuchi
kn-aut-mei=Susumu
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Industrial Science, Scool of Engineering Okayama University

affil-num=2
en-affil=
kn-affil=Department of Industrial Science, Scool of Engineering Okayama University

affil-num=3
en-affil=
kn-affil=Department of Industrial Science, Scool of Engineering Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=
article-no=
start-page=65
end-page=81
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790305
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Computer Program for Numerical Evaluation of the work
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We try to evaluate the manual work numerically from a point of view of the homogeneousness and the simultaneousness of both hands using the results of the micromotion study. The weighted coefficient and the balance index are used to evaluate the homogeneousness of both hands. And the simultaneous index is used to evaluate the simultaneous movement of both hands. It is necessary to make a program in order to use efficiently the method to calculate the indexes or the coefficients. Therefore the computer program of these methods is mentioned in this paper.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=UshioJunichi
kn-aut-sei=Ushio
kn-aut-mei=Junichi
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=OsakiHirokazu
kn-aut-sei=Osaki
kn-aut-mei=Hirokazu
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=KikuchiSusumu
kn-aut-sei=Kikuchi
kn-aut-mei=Susumu
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Industrial Science

affil-num=2
en-affil=
kn-affil=Department of Industrial Science

affil-num=3
en-affil=
kn-affil=Department of Industrial Science
END

start-ver=1.4
cd-journal=joma
no-vol=1
cd-vols=
no-issue=1
article-no=
start-page=98
end-page=105
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1966
dt-pub=19660331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Simulator of Waiting Line Problems
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Demand and supply of service are complicatedly related with the balance between fixed capital and circulating capital, movement to the left or right side from a break-even point, and other factors. If there is the disproportion between
demand and supply of service, the waiting line to take a service will vary, and in some cases, fixed equipment will not be employed effectively. This report presents trial manufacture of the experimental equipment for waiting line problems.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=KikuchiSusumu
kn-aut-sei=Kikuchi
kn-aut-mei=Susumu
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=TomiyaNobuaki
kn-aut-sei=Tomiya
kn-aut-mei=Nobuaki
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Industrial Science

affil-num=2
en-affil=
kn-affil=Department of Industrial Science
END

start-ver=1.4
cd-journal=joma
no-vol=1
cd-vols=
no-issue=1
article-no=
start-page=63
end-page=69
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1966
dt-pub=19660331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Approximate Solution of Nonlinear Oscillatory Circuits (I)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The well-known steady state solution of nonlinear oscillatory circuits based on the use of Fourier series, the so-called harmonic balance, is a powerful method because of its wide applicability. Yet, this method has not only difficulties to solve transcendental equations or algebraic equations of higher orders, but gives no transient state solution. The harmonic approximation and the extended harmonic approximation defined in this report are linearization methods which give approximations of steady state and transient state simultaneously.
Furthermore the method enables an unification and extension of miscellaneous
linearization methods.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=MineTadao
kn-aut-sei=Mine
kn-aut-mei=Tadao
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=YamamotoTatuma
kn-aut-sei=Yamamoto
kn-aut-mei=Tatuma
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=BabaYukinobu
kn-aut-sei=Baba
kn-aut-mei=Yukinobu
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=2
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=3
en-affil=
kn-affil=Department of Electrical Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=115
end-page=133
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=19891129
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Trends in the Regional Structure of Manufacturing Industries in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The rapid economic growth of Japan in the postwar period has brought about the over-concentration of activities in a few large cities, and local regions have been losing their economic vitality due to the regional differentials and the population loss. Regional development planning in Japan has sought to achieve a balanced growth of the nation through the development of industries in local regions. This paper aims to examine the regional structure of manufacturing industries in the postwar period and to
identify its current problems. Three methods, namely the analysis of coefficient of variation, the rateshare analysis and the shift-share analysis are applied using employment data of manufacturing industries for the years 1955 to 1985. Findings show that while the employment of manufacturing industries has been markedly decentralized from metropolitan to local regions, the disparities in growth rates still exist among regions.
en-copyright=
kn-copyright=

en-aut-name=AbeHirofumi
en-aut-sei=Abe
en-aut-mei=Hirofumi
kn-aut-name=阿部宏史
kn-aut-sei=阿部
kn-aut-mei=宏史
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NogataMikio
kn-aut-sei=Nogata
kn-aut-mei=Mikio
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Civil Engineering

affil-num=2
en-affil=
kn-affil=Okayama Prefectural Office
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=1
article-no=
start-page=75
end-page=94
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19911130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Urban Expressway Pricing under Constraint
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Four radials-single ring urban expressway network is priced and, simultaneously, optimized in its spatial formation under the constraint that a balance must be kept of revenue and expenditure. The model consists of three sub-models: road system, car trip generation-attraction and traffic diversion. Network performance is assessed on two criteria; trip number criterion on which the aggregate number of car trips diverted onto expressway is maximized and travel hour criterion on which the travel hours of car trips integrated over the road system; surface and expressway, is minimized. Optimization is tried by numerical calculation for some sets of parameters in the model. The results are summarized as follows; (1) simultaneous optimization of price and spatial formation of the expressway network is possible on each of criteria, (2) trip number criterion produces lower pricing and smaller network while travel hour criterion does higher pricing and larger network, (3) optimum solution lies in a delicate relation of price and spatial network formation that comes from the balance constraint.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=MyojinSho
kn-aut-sei=Myojin
kn-aut-mei=Sho
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NoguchiHisahumi
kn-aut-sei=Noguchi
kn-aut-mei=Hisahumi
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=YamadaMasahito
kn-aut-sei=Yamada
kn-aut-mei=Masahito
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Civil Engineering

affil-num=2
en-affil=
kn-affil=Daiwa Housing Co.

affil-num=3
en-affil=
kn-affil=Department of Civil Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=2
article-no=
start-page=65
end-page=74
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=19990226
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of an aptitude scale for nursing students
kn-title=看護学生の適性に関する尺度開発の試み ―信頼性･妥当性の検証―
en-subtitle=
kn-subtitle=
en-abstract=Efforts to ensure the necessary aptitude for health care professionals as well as knowledge and skills taught to nursing students are important to provide proper health services and care. A questionnaire containing 22 items was developed to evaluate teaching effectiveness. These items were obtained from previous studies and our findings in nursing practice and teaching. Stability reliability of this method was estimated using test/retest. The correlation coefficient for individual items ranged from 0.36 to 0.71. Only 2 of the 22 items showed correlation values below 0.40. Internal reliability of the 5 subscales was determined using the Cronbach's alpha coefficient 0.83. The values ranged from 0.56 to 0.80. Five components extracted by factor analysis were identified as follows : <Leadership> <Sociability> <Spirit of inquiring> <Well-balanced personality> and <Patience>.
kn-abstract=看護教育では,看護者として必要な知識,技術のみならず看護するのにふさわしい態度や姿勢等を育成することを重視している｡このような看護者にふさわしい態度形成を援助する教育の成果を評価するために看護学生の適性に関する尺度開発を試みた｡尺度に用いる項目は,看護者にふさわしい態度や性格特性及び適性等に関する過去の文献調査と筆者等の臨床看護及び看護教育の経験とで検討し決定した｡最終的に絞り込んだ項目は,22項目であった｡この項目の信頼性･妥当性を検証するために,医療技術短大の看護学生206人を対象に質問紙調査を実施した｡信頼性については,76人を対象に再検査を実施し安定性を検討した｡その結果,相関係数の一番低い項目は｢研究心｣｢自制心｣で,0.36であった｡残りの項目は,相関係数0.40以上で,一番高い項目は｢冷静｣の0.71であった｡内的整合性を示すCronbach's α信頼性係数は,全項目では0.83であった｡因子分析の結果得られた5因子に基づく下位尺度のCronbach's α信頼性係数は,最も高いものは<リーダーシップ>0.80であり,最も低いものは<精神的成熟>0.56であった｡構成概念の妥当性を検討するために因子分析をおこなった結果,5因子が抽出された｡それぞれを<リ
ーダーシップ><社会性><探求心><精神的成熟><忍耐>と命名し,下位尺度とした｡
en-copyright=
kn-copyright=

en-aut-name=IkedaToshiko
en-aut-sei=Ikeda
en-aut-mei=Toshiko
kn-aut-name=池田敏子
kn-aut-sei=池田
kn-aut-mei=敏子
aut-affil-num=1
ORCID=

en-aut-name=KondohIsao
en-aut-sei=Kondoh
en-aut-mei=Isao
kn-aut-name=近藤勲
kn-aut-sei=近藤
kn-aut-mei=勲
aut-affil-num=2
ORCID=

en-aut-name=TanakaKoji
en-aut-sei=Tanaka
en-aut-mei=Koji
kn-aut-name=田中宏二
kn-aut-sei=田中
kn-aut-mei=宏二
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻

affil-num=2
en-affil=
kn-affil=岡山大学教育学部

affil-num=3
en-affil=
kn-affil=岡山大学教育学部
en-keyword=看護学生 (nursing students)
kn-keyword=看護学生 (nursing students)
en-keyword=看護教育 (nursing education)
kn-keyword=看護教育 (nursing education)
en-keyword=看護 (nursing)
kn-keyword=看護 (nursing)
en-keyword=適性 (aptitude)
kn-keyword=適性 (aptitude)
en-keyword=尺度 (scale)
kn-keyword=尺度 (scale)
END