result 486 件
| FullText URL | K0006020_abstract_review.pdf K0006020_summary.pdf K0006020_fulltext.pdf |
|---|---|
| Author | Oda, Naohiro| |
| Published Date | 2019-06-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6020号 |
| Granted Date | 2019-06-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0006013_abstract_review.pdf K0006013_summary.pdf K0006013_fulltext.pdf |
|---|---|
| Author | Hamanishi, Seiji| |
| Published Date | 2019-06-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6013号 |
| Granted Date | 2019-06-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/56860 |
|---|---|
| FullText URL | 73_3_189.pdf |
| Author | Sakamoto, Shinji| Kawai, Hiroki| Okahisa, Yuko| Tsutsui, Ko| Kanbayashi, Takashi| Tanaka, Keiko| Mizuki, Yutaka| Takaki, Manabu| Yamada, Norihito| |
| Abstract | Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently-discovered autoimmune disorder in which antibodies target NMDAR in the brain. The number of reported cases of anti-NMDAR encephalitis has increased rapidly. Anti-NMDAR encephalitis can be mistakenly diagnosed as psychiatric disorders because many patients present with prominent psychiatric symptoms and visit psychiatric institutions first. Thus, psychiatrists should cultivate a better understanding of anti-NMDAR encephalitis. In this review, we present the mechanisms, epidemiology, symptoms and clinical course, diagnostic tests, treatment and outcomes of patients with anti-NMDAR encephalitis. Furthermore, we discuss the diversity of clinical spectra of anti-NMDAR encephalitis, and demonstrate a differential diagnosis of psychiatric disease from the perspective of psychiatry. |
| Keywords | NMDAR encephalitis psychiatric symptom schizophrenia mood disorder |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 189 |
| End Page | 195 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235965 |
| FullText URL | K0005976_abstract_review.pdf K0005976_fulltext.pdf |
|---|---|
| Author | Tsuneyoshi, Toshihiko| |
| Published Date | 2019-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5976号 |
| Granted Date | 2019-03-25 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005959_abstract_review.pdf K0005959_summary.pdf K0005959_fulltext.pdf |
|---|---|
| Author | Fujiwara, Hirokazu| |
| Published Date | 2019-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5959号 |
| Granted Date | 2019-03-25 |
| Thesis Type | Doctor of Philosophy in Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005880_abstract_review.pdf K0005880_summary.pdf K0005880_fulltext.pdf |
|---|---|
| Author | Abe, Makoto| |
| Published Date | 2019-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5880号 |
| Granted Date | 2019-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005875_abstract_review.pdf K0005875_summary.pdf K0005875_fulltext.pdf |
|---|---|
| Author | Miyake, Takamasa| |
| Published Date | 2019-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5875号 |
| Granted Date | 2019-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/56646 |
|---|---|
| FullText URL | 73_2_109.pdf |
| Author | Abe, Makoto| Iwamuro, Masaya| Kawahara, Yoshiro| Kanzaki, Hiromitsu| Kawano, Seiji| Tanaka, Takehiro| Tsumura, Munechika| Makino, Takuma| Noda, Yohei| Marunaka, Hidenori| Nishizaki, Kazunori| Okada, Hiroyuki| |
| Abstract | The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. “Resect and watch” is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer. |
| Keywords | endoscopic submucosal dissection superficial cancer pharynx endoscopic resection |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-04 |
| Volume | volume73 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 109 |
| End Page | 115 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31015745 |
| FullText URL | K0005861_abstract_review.pdf K0005861_summary.pdf K0005861_fulltext.pdf |
|---|---|
| Author | Kashihara, Naoko| |
| Published Date | 2018-12-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5861号 |
| Granted Date | 2018-12-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005810_abstract_review.pdf K0005810_fulltext.pdf K0005810_summary.pdf |
|---|---|
| Author | Lu, ZhicHao| |
| Published Date | 2018-09-27 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5810号 |
| Granted Date | 2018-09-27 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/56254 |
|---|---|
| FullText URL | 72_5_535.pdf |
| Author | Sato, Daisuke| Gohda, Tomohito| Kihara, Masao| Kanaguchi, Yasuhiko| Kobayashi, Takashi| Mano, Satoshi| Sasaki, Yu| Nohara, Nao| Murakoshi, Maki| Nakata, Junichiro| Suzuki, Hitoshi| Ueda, Seiji| Horikoshi, Satoshi| Suzuki, Yusuke| |
| Abstract | Some patients with chronic kidney disease (CKD) receiving hemodialysis develop erythropoietin-resistant anemia, possibly due to zinc deficiency. The frequency of zinc deficiency in CKD (stages 1-5 and 5D) and CKD improvement via zinc supplementation are not completely verified. Here 500 CKD patients (Stage 1/2, n=100; Stage 3, n=100; Stage 4, n=100, Stage n=5, 100; Stage 5D, n=100) will be recruited to determine the frequency of serum zinc deficiency at each CKD stage. Patients with serum zinc concentrations <80 μg/dL will be treated with zinc acetate dihydrate (NobelzinR) to evaluate its effects on hypozincemia, taste disturbances, and anemia. |
| Keywords | zinc acetate dihydrate anemia chronic kidney disease |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 535 |
| End Page | 538 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369613 |
| FullText URL | J_Org_Chem_80_6_3111.pdf |
|---|---|
| Author | Takamura, Hiroyoshi| Wada, Hiroko| Ogino, Mao| Kikuchi, Takahiro| Kadota, Isao| Uemura, Daisuke| |
| Note | This is an Accepted Manuscript of an article published by American Chemical Society| This research was supported by a Grant-in Aid for Scientific Research (No. 24710250) from the Japan Society for the Promotion of Science (JSPS).| |
| Published Date | 2015-02-27 |
| Publication Title | The Journal of organic chemistry |
| Volume | volume80 |
| Issue | issue6 |
| Publisher | American Chemical Society |
| Start Page | 3111 |
| End Page | 3123 |
| ISSN | 00223263 |
| NCID | AA00704100 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 25723589 |
| DOI | 10.1021/acs.joc.5b00027 |
| Web of Science KeyUT | 000351558400017 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.joc.5b00027 |
| FullText URL | Chemistry_22_6_1984.pdf |
|---|---|
| Author | Takamura, Hiroyoshi| Fujiwara, Takayuki| Kawakubo, Yohei| Kadota, Isao| Uemura, Daisuke| |
| Keywords | macrocycles natural products polyols stereodivergent synthesis structure elucidation |
| Note | This is an article published by WILEY‐VCH| We acknowledge JGC-S Scholarship Foundation, The Naito Foundation, The Sumitomo Foundation, and The Uehara Memorial Foundation for their financial supports. This research was supported by a Grant-in Aid for Scientific Research (No. 24710250) from the Japan Society for the Promotion of Science (JSPS).| |
| Published Date | 2016-02 |
| Publication Title | Chemistry - A European Journal |
| Volume | volume22 |
| Issue | issue6 |
| Publisher | WILEY‐VCH |
| Start Page | 1984 |
| End Page | 1996 |
| ISSN | 0947-6539 |
| NCID | AA11076269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 26742818 |
| DOI | 10.1002/chem.201503881 |
| Web of Science KeyUT | 000368925200016 |
| Related Url | isVersionOf https://doi.org/10.1002/chem.201503881 |
| FullText URL | Chemistry_22_6_1979.pdf |
|---|---|
| Author | Takamura, Hiroyoshi| Fujiwara, Takayuki| Kawakubo, Yohei| Kadota, Isao| Uemura, Daisuke| |
| Keywords | macrocycles natural products polyols stereoselective synthesis structure elucidation |
| Note | This is an article published by Wiley-VCH| We appreciate JGC-S Scholarship Foundation, The Naito Foundation, The Sumitomo Foundation, and The Uehara Memorial Foundation for their financial supports. This research was supported by a Grant-in Aid for Scientific Research (No. 24710250) from the Japan Society for the Promotion of Science (JSPS)| |
| Published Date | 2016-02 |
| Publication Title | Chemistry - A European Journal |
| Volume | volume22 |
| Issue | issue6 |
| Publisher | Wiley-VCH |
| Start Page | 1979 |
| End Page | 1983 |
| ISSN | 0947-6539 |
| NCID | AA11076269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 26661715 |
| DOI | 10.1002/chem.201503880 |
| Web of Science KeyUT | 000368925200015 |
| Related Url | isVersionOf https://doi.org/10.1002/chem.201503880 |
| FullText URL | Chemistry_23_68_17191.pdf |
|---|---|
| Author | Takamura, Hiroyoshi| Katsube, Tomoya| Okamoto, Kazuki| Kadota, Isao| |
| Keywords | natural products stereoselective synthesis structure elucidation tetrahydrofuran total synthesis |
| Note | This is an article published by Wiley‐VCH| |
| Published Date | 2017-12-06 |
| Publication Title | Chemistry - A European Journal |
| Volume | volume23 |
| Issue | issue68 |
| Publisher | Wiley‐VCH |
| Start Page | 17191 |
| End Page | 17194 |
| ISSN | 09476539 |
| NCID | AA11076269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 29083058 |
| DOI | 10.1002/chem.201703234 |
| Web of Science KeyUT | 000417508800005 |
| Related Url | isVersionOf https://doi.org/10.1002/chem.201703234 |
| JaLCDOI | 10.18926/AMO/56169 |
|---|---|
| FullText URL | 72_4_343.pdf |
| Author | Nishie, Hiroyuki| Tetsunaga, Tomoko| Kanzaki, Hirotaka| Oda, Koji| Inoue, Shinichiro| Ryuo, Yuta| Ota, Haruyuki| Miyawaki, Takuya| Arakawa, Kyosuke| Tetsunaga, Tomonori| Kitamura, Yoshihisa| Sendo, Toshiaki| Morimatsu, Hiroshi| Ozaki, Toshifumi| Nishida, Keiichiro| |
| Abstract | We conducted this study to determine the short-term treatment outcomes of multidisciplinary approaches to chronic pain management for outpatients in Japan. We evaluated pain reduction and improvement in quality of life (QOL) after treatment. We analyzed 32 patients who had experienced intractable chronic pain for > 3 months. The patients received multidisciplinary therapeutic self-managed exercise instructions and then underwent evaluations 1 and 3 months after the treatment. We used the Pain Disability Short Form-36 (SF-36), Pain Catastrophizing Scale (PCS), and Pain Disability Assessment Scale (PDAS) to evaluate QOL. Although the pain levels were the same before and after the physical exercise program, the patients showed significant improvements in physical function on the SF-36 (48.5 vs. 54.5, 3 months vs. 1 month; p=0.0124), the magnification subscale on the PCS (6.8 vs. 5.9, 1 month vs. before; p=0.0164) and the PDAS (29.2 vs. 23.4, 3 months vs. before; p=0.0055). Chronic pain should be treated with a biopsychosocial approach, but time constraints and costs have limited the implementation of multidisciplinary and behavioral approaches to chronic pain management. Our findings demonstrate that clinical improvements are possible for patients with chronic pain, using multidisciplinary team resources widely available in Japanese clinical practice. |
| Keywords | multidisciplinary treatment pain management quality of life biopsychosocial approach chronic pain |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-08 |
| Volume | volume72 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 343 |
| End Page | 350 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30140081 |
| FullText URL | K0005736_abstract_review.pdf K0005736_fultext.pdf |
|---|---|
| Author | Fujii, Kazuki| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5736号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005676_abstract_review.pdf K0005676_summary.pdf K0005676_fulltext.pdf |
|---|---|
| Author | Miyawaki, Yoshia| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5676号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/55857 |
|---|---|
| FullText URL | 72_2_165.pdf |
| Author | Yoshida, Aki| Fujiwara, Tomohiro| Uotani, Koji| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hasei, Joe| Nakata, Eiji| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Abstract | Although there is considerable evidence indicating that the dysregulation of microRNAs (miRNAs) in malignant tumors plays a role in tumor development, the overall function of miRNAs and their clinicopathological significance are not well understood. In this retrospective analysis of 45 biopsy specimens from osteosarcoma (OS) patients, we investigated the functional and clinical significance of miR-25-3p in OS, which we previously identified as a highly expressed miRNA in OS patients’ serum. We observed that miR-25-3p dysregulation in human OS tissues was negatively correlated with the clinical prognosis, whereas the expression level of its target gene, Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3), was positively correlated with the clinical prognosis. Endogenous miR-25-3p upregulation promoted tumor growth, invasion, and drug resistance, which was consistent with DKK3 silencing in OS cells. In addition, secretory miR-25-3p was embedded in tumor-derived exosomes, where it promoted capillary formation and the invasion of vascular endothelial cells. Overall, our results show that miR-25-3p has intracellular and extracellular oncogenic functions as well as clinicopathological relevance in OS, indicating its potential as a novel diagnostic and therapeutic tool for the clinical management of this disease. |
| Keywords | microRNA circulating microRNA osteosarcoma prognosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-04 |
| Volume | volume72 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 165 |
| End Page | 174 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29674765 |
| FullText URL | fest_023_103_115.pdf |
|---|---|
| Author | 岡山大学環境理工学部| |
| Publication Title | 岡山大学環境理工学部研究報告 |
| Published Date | 2018-03 |
| Volume | volume23 |
| Issue | issue1 |
| Start Page | 103 |
| End Page | 115 |
| ISSN | 2187-6940 |
| language | Japanese |
| File Version | publisher |
