result 40852 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Torigata, Kosuke| Matsuura, Ryohei| Nagatomo, Fumiya| Thiha, Moe| Hikita, Takao| Iseoka, Hiroko| Takagi, Hiromitsu| Koshimizu, Uichi| Sakakima, Hiroki| Izumi, Satoshi| Hatano, Asuka| Braun, Thomas| Sawa, Yoshiki| Miyagawa, Shigeru| Nakayama, Masanori| |
| Keywords | cell biology fibrosis stem cell research |
| Published Date | 2026-04 |
| Publication Title | iScience |
| Volume | volume29 |
| Issue | issue4 |
| Publisher | Elsevier BV |
| Start Page | 115341 |
| ISSN | 2589-0042 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 The Author(s). |
| File Version | publisher |
| PubMed ID | 41953004 |
| DOI | 10.1016/j.isci.2026.115341 |
| Web of Science KeyUT | 001732109200001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.isci.2026.115341 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Motoki, Ko| Kakita, Nami| Goto, Tanjuro| Yasuba, Ken-ichiro| |
| Keywords | FLOWERING LOCUS T (FT) Florigen Red/far-red ratio Graft-mediated floral induction Radish (Raphanus sativus) Cabbage (Brassica oleracea) Brassica rapa |
| Published Date | 2026-04 |
| Publication Title | Scientia Horticulturae |
| Volume | volume361 |
| Publisher | Elsevier BV |
| Start Page | 114818 |
| ISSN | 0304-4238 |
| NCID | AA00836848 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 The Author(s). |
| File Version | publisher |
| DOI | 10.1016/j.scienta.2026.114818 |
| Related Url | isVersionOf https://doi.org/10.1016/j.scienta.2026.114818 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kanna, Naoya| Obata, Hajime| Kondo, Yoshiko| |
| Keywords | Trace metals Solid-phase extraction Chelating resin InertSep ME-2 |
| Published Date | 2026-05 |
| Publication Title | Marine Chemistry |
| Volume | volume276 |
| Publisher | Elsevier BV |
| Start Page | 104642 |
| ISSN | 0304-4203 |
| NCID | AA0072137X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 The Authors. |
| File Version | publisher |
| DOI | 10.1016/j.marchem.2026.104642 |
| Related Url | isVersionOf https://doi.org/10.1016/j.marchem.2026.104642 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kitamura, Naoto| Tang, Yizhong| Kimura, Koji| Obayashi, Ippei| Onodera, Yohei| Nakashima, Ken| Ishibashi, Chiaki| Idemoto, Yasushi| Hayashi, Koichi| |
| Keywords | A-site-deficient perovskite Li+ conduction Total scattering Local structure Persistent homology |
| Published Date | 2026-04-01 |
| Publication Title | Journal of the Ceramic Society of Japan |
| Volume | volume134 |
| Issue | issue4 |
| Publisher | Ceramic Society of Japan |
| Start Page | 225 |
| End Page | 231 |
| ISSN | 1348-6535 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | ©2025 The Ceramic Society of Japan |
| File Version | publisher |
| DOI | 10.2109/jcersj2.25074 |
| Web of Science KeyUT | 001722002900001 |
| Related Url | isVersionOf https://doi.org/10.2109/jcersj2.25074 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shoji, Ryohei| Tazawa, Hiroshi| Kuroda, Shinji| Nishiyama, Takeyoshi| Kajiwara, Yoshinori| Yamada, Motohiko| Nagai, Yasuo| Inoue, Hiroaki| Hashimoto, Naoyuki| Kikuchi, Satoru| Yoshida, Ryuichi| Umeda, Yuzo| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Keywords | MT: Regular Issue pancreatic cancer glycolysis oncolytic virotherapy CPI-613 PET/CT |
| Published Date | 2026-06 |
| Publication Title | Molecular Therapy Oncology |
| Volume | volume34 |
| Issue | issue2 |
| Publisher | Elsevier BV |
| Start Page | 201180 |
| ISSN | 2950-3299 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 The Author(s). |
| File Version | publisher |
| DOI | 10.1016/j.omton.2026.201180 |
| Web of Science KeyUT | 001740821000001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.omton.2026.201180 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Masuzawa, K.| Foggiatto, A. L.| Kunii, S.| Nagaoka, R.| Taniwaki, M.| Yamazaki, T.| Mitsumata, C.| Obayashi, I.| Hiraoka, Y.| Kotsugi, M.| |
| Published Date | 2026-02-11 |
| Publication Title | Scientific Reports |
| Volume | volume16 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 12889 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2026 |
| File Version | publisher |
| PubMed ID | 41667607 |
| DOI | 10.1038/s41598-026-39617-x |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-026-39617-x |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Chowdhury, Goutam| Bhattacharya, Sanjay| Goel, Gaurav| Chatterji, Soumyadip| Kitahara, Kei| Ohno, Ayumu| Lewis, Melissa Glenda| Miyoshi, Shin-ichi| Ramamurthy, Thandavarayan| Mukhopadhyay, Asish K.| |
| Keywords | Salmonella enterica Cancer Virulence Antimicrobial resistance PFGE |
| Published Date | 2025-10-09 |
| Publication Title | BMC Infectious Diseases |
| Volume | volume25 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1263 |
| ISSN | 1471-2334 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025. |
| File Version | publisher |
| PubMed ID | 41068693 |
| DOI | 10.1186/s12879-025-11679-8 |
| Web of Science KeyUT | 001591441800009 |
| Related Url | isVersionOf https://doi.org/10.1186/s12879-025-11679-8 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kundu, Sushmita| Das, Suman| Maitra, Priyanka| Halder, Prolay| Koley, Hemanta| Mukhopadhyay, Asish K.| Miyoshi, Shin-ichi| Dutta, Shanta| Chatterjee, Nabendu Sekhar| Bhattacharya, Sushmita| |
| Keywords | sodium butyrate (SB) inhibitor pathogenesis Vibrio cholerae ctxAB antimicrobial resistance toxin-coregulated pilus (TcpA) |
| Published Date | 2025-05-27 |
| Publication Title | mSphere |
| Volume | volume10 |
| Issue | issue5 |
| Publisher | American Society for Microbiology |
| Start Page | e00824-24 |
| ISSN | 2379-5042 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Kundu et al. |
| File Version | publisher |
| PubMed ID | 40261078 |
| DOI | 10.1128/msphere.00824-24 |
| Web of Science KeyUT | 001471908900001 |
| Related Url | isVersionOf https://doi.org/10.1128/msphere.00824-24 |
| Author | Morihara, Ryuta| Nomura, Emi| Osakada, Yosuke| Yunoki, Taijun| Takemoto, Mami| Yamashita, Toru| Ishiura, Hiroyuki| |
|---|---|
| Keywords | Corticobasal degeneration CBD Corticobasal syndrome CBS Armstrong's criteria |
| Note | © 2026 Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Feb. 2027.| |
| Published Date | 2026-04 |
| Publication Title | Parkinsonism & Related Disorders |
| Volume | volume145 |
| Publisher | Elsevier BV |
| Start Page | 108229 |
| ISSN | 1353-8020 |
| NCID | AA11054368 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 Published by Elsevier Ltd. |
| File Version | author |
| PubMed ID | 41671870 |
| DOI | 10.1016/j.parkreldis.2026.108229 |
| Web of Science KeyUT | 001689377900001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.parkreldis.2026.108229 |
| Author | Nomura, Emi| Morihara, Ryuta| Osakada, Yosuke| Yunoki, Taijun| Takemoto, Mami| Yamashita, Toru| Ishiura, Hiroyuki| |
|---|---|
| Keywords | Amyotrophic lateral sclerosis ALS Gold Coast criteria Revised El Escorial criteria Awaji criteria |
| Note | © 2026 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jan. 2027.| |
| Published Date | 2026-02 |
| Publication Title | Journal of the Neurological Sciences |
| Volume | volume481 |
| Publisher | Elsevier BV |
| Start Page | 125733 |
| ISSN | 0022-510X |
| NCID | AA00703265 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 Elsevier B.V. |
| File Version | author |
| PubMed ID | 41534442 |
| DOI | 10.1016/j.jns.2026.125733 |
| Web of Science KeyUT | 001668514200001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jns.2026.125733 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kitamura, Hiroshi| Matsushima, Noriaki| Sato, Misato| |
| Keywords | Durable goods Exclusive supply chain Vertical relation Selling versus leasing |
| Published Date | 2026-07 |
| Publication Title | Transportation Research Part E: Logistics and Transportation Review |
| Volume | volume211 |
| Publisher | Elsevier BV |
| Start Page | 104882 |
| ISSN | 1366-5545 |
| NCID | AA11125309 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2026 The Author(s). |
| File Version | publisher |
| DOI | 10.1016/j.tre.2026.104882 |
| Related Url | isVersionOf https://doi.org/10.1016/j.tre.2026.104882 |
| JaLCDOI | 10.18926/AMO/70458 |
|---|---|
| FullText URL | 80_2_153.pdf |
| Author | Ueda, Yoshiyuki| Yumoto, Tetsuya| Hongo, Takashi| Obara, Takafumi| Nojima, Tsuyoshi| Tsukahara, Kohei| Hasegawa, Kosei| Futagawa, Natsuko| Naito, Hiromichi| Nakao, Atsunori| |
| Abstract | Adrenal crisis is a life-threatening endocrine emergency that can progress within hours despite a prior diagnosis and maintenance therapy. We describe a fatal influenza-triggered adrenal crisis in two patients: a child with panhypopituitarism and an adult with prior pituitary surgery, both presenting in cardiac arrest. Despite resuscitation and intravenous hydrocortisone, a fatal hypoxic-ischemic injury or multiorgan failure occurred. These cases highlight the fulminant course of an adrenal crisis and underscore the importance of early recognition, clinician awareness, prompt parenteral hydrocortisone administration, and reinforcement of education for patients, caregivers, and healthcare providers to improve preparedness and prevent avoidable deaths. |
| Keywords | adrenal insufficiency cardiac arrest hydrocortisone influenza shock |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-04 |
| Volume | volume80 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 153 |
| End Page | 157 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/70457 |
|---|---|
| FullText URL | 80_2_147.pdf |
| Author | Sakamoto, Shinya| Tabuchi, Motoyasu| Hamada, Akira| Yoshimatsu, Rika| Saisaka, Yuichi| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro| |
| Abstract | Common bile duct (CBD) injury after blunt abdominal trauma is rare and difficult to diagnose. Delayed recognition leads to severe morbidity. A 70-year-old Japanese man was admitted after sustaining blunt abdominal trauma. Ultrasonography revealed intra-abdominal fluid, suggesting bleeding. Contrast-enhanced computed tomography revealed pancreatic head injury, intra-abdominal bleeding, and pseudoaneurysm of the anterior superior pancreatoduodenal artery (ASPDA). Bile duct injury was not evident. The application of transarterial embolization (TAE) controlled the bleeding. Canulation into the pancreatic or biliary duct was not possible during endoscopic retrograde cholangiopancreatography. An emergency laparotomy revealed severe pancreatic head and extrahepatic bile duct injuries. Pancreaticoduodenectomy/Child reconstruction was performed. Complete CBD transection was confirmed. The patient was ultimately discharged without complications. Early recognition, timely surgical management, and intensive care are essential for favorable outcomes in patients who have sustained abdominal trauma. |
| Keywords | blunt abdominal trauma intensive care emergency laparotomy pancreatoduodenectomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-04 |
| Volume | volume80 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 147 |
| End Page | 152 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/70456 |
|---|---|
| FullText URL | 80_2_141.pdf |
| Author | Sakamoto-Tokunaga, Moe| Katsuyama, Takayuki| Matoba, Masaki| Tamura, Tomokazu| Kubota, Natsuki| Terajima, Yuya| Shidahara, Kenta| Hirose, Kei| Matsumoto, Kazuya| Nawachi, Shoichi| Nakadoi, Takato| Katayama, Yu| Hayashi, Keigo| Miyawaki, Yoshia| Katsuyama, Eri| Watanabe, Haruki| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Sada, Ken-Ei| Tsuji, Shuma| Gotoh, Kazuyoshi| Fukushima, Shinnosuke| Hagiya, Hideharu| Wada, Jun| |
| Abstract | VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory somatic) syndrome has a poor prognosis, with infections being a major cause of death. Raoultella ornithinolytica is an environmental bacterium found predominantly in soil and water. Although R. ornithinolytica can cause various infections, necrotizing fasciitis due to this bacterium has not been reported. We describe the case of an 84-year-old Japanese male with VEXAS syndrome who developed septic shock and necrotizing fasciitis while he was under immunosuppressive therapy. The pathogen was initially misidentified as R. planticola by mass spectrometry but later confirmed by whole-genome sequencing as extended spectrum β-lactamase (ESBL) produced by R. ornithinolytica. Although a life-saving leg amputation was required, the patient recovered with appropriate antibiotic therapy. R. ornithinolytica is thus able to cause severe skin infections in immunocompromised individuals. |
| Keywords | necrotizing fasciitis Raoultella ornithinolytica VEXAS syndrome whole-genome sequence |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-04 |
| Volume | volume80 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 141 |
| End Page | 145 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/70455 |
|---|---|
| FullText URL | 80_2_131.pdf |
| Author | Nakata, Shunsuke| Takatsu, Fumiaki| Mikuriya, Yoshihiro| Kakishita, Tomokazu| Hato, Shinji| Ohta, Koji| Kobatake, Takaya| |
| Abstract | Colorectal surgery is associated with a high incidence of postoperative complications regardless of the advances in surgical techniques and multidisciplinary treatment. Proteinuria is common in patients with malignancies, but few studies have investigated the association between preoperative proteinuria and patient prognoses, especially postoperative complications. We investigated the impact of proteinuria on patients undergoing colorectal surgery in a single-center, retrospective cohort study of 767 patients who underwent surgical resection for colorectal cancer between January 2016 and December 2022 at the National Hospital Organization Shikoku Cancer Center. Among them, 81 patients with preoperative proteinuria were compared with the control group of 686 patients without proteinuria. Our analyses revealed that the patients with proteinuria had malnutrition with a significantly lower prognostic nutritional index compared to the no-proteinuria control group (p<0.001). The proteinuria group had a significantly advanced tumor stage (p=0.005), experienced more bleeding during the surgery (p=0.002), and required more transfusions (p<0.001). Postoperative complications were significantly more frequent in the proteinuria group (p=0.03), thus demonstrating that proteinuria was independently associated with postoperative complications (p=0.045). Proteinuria in patients undergoing colorectal cancer surgery can therefore be considered a risk factor for postoperative complications. |
| Keywords | colorectal cancer surgery proteinuria complication malnutrition |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-04 |
| Volume | volume80 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 131 |
| End Page | 139 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/70454 |
|---|---|
| FullText URL | 80_2_119.pdf |
| Author | Ikuma, Hisanori| Hirose, Tomohiko| Kawasaki, Keisuke| Otsuka, Kazutoshi| |
| Abstract | We evaluated the clinical outcomes and limitations of anterior and posterior combined surgery with a mini-open corpectomy applying an expandable cage (Xcore®) and percutaneous pedicle screw (PPS) fixation using single-position surgery in the lateral decubitus position in patients aged > 75 years with thoracolumbar vertebral collapse. The cases of 30 consecutive patients who underwent this procedure and had ≥ 1-year follow-up were retrospectively analyzed. The mean operative time was 78.8 min and the estimated blood loss was 115.7 ml per level. The complications included adjacent junctional failure (n=9, 30%), deep venous thrombosis (n=3, 10%), delirium (n=3, 10%), pleural injury (n=2, 6%), screw backout (n=1, 3%) kidney injury (n=1, 3%), chylothorax (n=1, 3%), and wound dehiscence (n=1, 3%). Seven cases (23.3%) required reoperation. Local kyphosis showed significant improvement (p<0.05) that was maintained at the final follow-up. The Japanese Orthopaedic Association Back Pain Evaluation Questionnaire and a visual analogue scale indicated significant improvement in all categories at the final follow-up (p<0.05). The use of mini-open corpectomy and posterior fixation with SPAPS can thus provide reliable radiological correction and good postoperative clinical outcomes even in patients aged > 75 years. However, a limitation of this procedure is the rate of reoperation (23.3%) for osteoporosis-related adjacent segment fracture and screw backout. |
| Keywords | single postion surgery osteoporotic vertebral collapse anterior and posterior combined surgery minimum invasive surgery |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-04 |
| Volume | volume80 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 119 |
| End Page | 129 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/70453 |
|---|---|
| FullText URL | 80_2_109.pdf |
| Author | Sonoi, Mika| Sonoi, Norihiro| Koyama, Yoko| |
| Abstract | This study examined the effects of interprofessional education (IPE) on dietetics students during clinical training, focusing on changes in their attitudes toward IPE and their fundamental competencies. Eighty third-year female students (mean age, 21.0 years) at a Japanese women’s university participated. Self-administered surveys were conducted before and after clinical training to assess attitudes toward IPE using the Readiness for Interprofessional Learning Scale (RIPLS) and the Shakaijin Kisoryoku (SKL; Fundamental Competencies for Working Persons) scale. Quantitative data were analyzed using paired t-tests, chi-squared tests, and cluster analyses. Qualitative data from open-ended responses were analyzed thematically. RIPLS and SKL scores increased significantly, from 65.3 to 68.9, and from 28. 4 to 33. 2, respectively (p<0.001). All 12 SKL items showed significant improvement. In free responses, “initiative” (66 mentions), “communication” (10), and “execution” (8) were the most frequently cited as improved competencies. Cluster analysis identified three groups: increasing scores (n=25), high baseline (n=30), and minimal change (n=25). No significant correlation was found between changes in RIPLS and SKL scores (r=−0.108, p=0.355). IPE integrated into clinical training may enhance dietetics students’ attitudes toward interprofessional collaboration and contribute to the development of professional identity. Individualized, phased IPE implementation is recommended to accommodate differences in learner readiness. |
| Keywords | interprofessional education dietetics students clinical training professional competencies transformative learning |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-04 |
| Volume | volume80 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 109 |
| End Page | 117 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/70452 |
|---|---|
| FullText URL | 80_2_099.pdf |
| Author | Nguyen Trung Thanh| Nakamichi, Ryo| Shimamura, Yasunori| Saito, Taichi| Ishihara, Takeshi| Furutani, Tomoki| Shitozawa, Hisakazu| Noda, Tomoyuki| Ozaki, Toshifumi| |
| Abstract | Although the performance of minimally invasive plate osteosynthesis (MIPO) via the anteroinferior approach is increasingly adopted for midshaft clavicle fractures, the influence of fracture morphology on clinical outcomes under a standardized protocol is unclear. We retrospectively analyzed the cases of 54 patients who underwent anteroinferior MIPO for an acute midshaft clavicle fracture (AO/OTA types B1, B2, B3) performed by a single surgeon across three affiliated institutions (2009-2022). We evaluated the clinical outcomes, i.e., the surgical time, incision length, radiographic union, reduction accuracy, range of motion, pain (visual analog scale [VAS]), and complications and compared them among the three AO/OTA subtypes. The mean incision length (3.4 cm) and surgical time (71-79 min) were similar among the groups (both p>0.2). All fractures achieved radiographic union at a mean of 3.5 months. Postoperative alignment and clavicular length were maintained (length reduction −1.0±2.2 mm [B1], −0.5±2.0 mm [B2], −0.6±1.8 mm [B3]; p=0.825; angulation −0.8±3.4°, −1.1±3.1°, −0.3±3.3°; p=0.888). At 3 months, shoulder elevation and abduction were 169°-175° (p=0.079) and 164°-175° (p=0.324). Pain was minimal (100-mm VAS: ≤1 mm; p=0.782). One plate-fatigue failure occurred; no supraclavicular-nerve symptoms were recorded. Anteroinferior MIPO yielded consistent outcomes across AO/OTA types, with excellent union rates, functional recovery, and few complications, indicating that this technique is safe and reproducible for the surgical management of midshaft clavicle fractures. |
| Keywords | clavicle fracture minimally invasive plate osteosynthesis anteroinferior plating AO/OTA classification |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-04 |
| Volume | volume80 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 99 |
| End Page | 107 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/70451 |
|---|---|
| FullText URL | 80_2_085.pdf |
| Author | Shiba, Takahiko| Takamori, Mitsuhito| Katagiri, Sayaka| Kobayashi, Ryota| Kawauchi, Aki| Ohsugi, Yujin| Lin, Peiya| Ekuni, Daisuke| Egusa, Masahiko| Iwata, Takanori| Maeda, Shigeru| |
| Abstract | Individuals with Down syndrome (DS) are more susceptible to periodontal disease; however, microbial changes following treatment remain insufficiently understood. This study evaluated the effects of nonsurgical periodontal therapy on clinical outcomes and oral microbiome dynamics in 6 patients with DS using 16S rRNA gene amplicon sequencing. Bacterial diversity, composition, network structure, and predicted functional pathways were analyzed using dental plaque samples. Bleeding on probing decreased significantly (p=0.047) after treatment, with a trend toward reduction in periodontal inflamed surface area (p=0.05). The abundance of Fusobacteria at the class level decreased significantly after treatment. The abundance of Mogibacterium timidum was higher in the pretreatment group than in the posttreatment group. M. timidum was positively correlated with Treponema denticola and associated with multiple bacterial taxa in the network during pretreatment. Predicted functional pathways related to aromatic compound degradation were more abundant in posttreatment samples than in pretreatment samples. An increase in the abundance of Fusobacterium and the positive correlation between T. denticola and M. timidum, together with their associations with other periodontal pathogens before treatment, may contribute to the development of periodontitis in individuals with DS. Nonsurgical periodontal therapy produces measurable clinical improvement and promotes microbial shifts in patients with DS. |
| Keywords | Down Syndrome 16S rRNA Gene Amplicon Sequencing periodontitis nonsurgical periodontal treatment oral microbiome |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-04 |
| Volume | volume80 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 85 |
| End Page | 97 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| JaLCDOI | 10.18926/AMO/70450 |
|---|---|
| FullText URL | 80_2_075.pdf |
| Author | Lin, Deting| Horita, Masahiro| Watanabe, Masahito| Hasei, Joe| Ohtsuki, Takashi| Otsuka, Noriaki| Ichikawa, Chinatsu| Shimizu, Noriyuki| Naniwa, Shuichi| Ozaki, Toshifumi| Nishida, Keiichiro| |
| Abstract | A disintegrin and metalloproteinase 12 (ADAM12) is known to be involved in chondrocyte proliferation and is upregulated in the synovial tissue of osteoarthritis (OA). However, the underlying mechanisms of ADAM12 on rheumatoid arthritis (RA) synovial cell proliferation remain unknown. Here, we investigated the role of ADAM12 in the proliferation of RA synovial fibroblasts (RASFs). The expression and localization of ADAM12 in RA synovial tissues were examined by immunohistochemistry and compared with OA and healthy control (HC) synovial tissues. The effect of inflammatory cytokines (TNF-α, TGF-β1, and PDGF-BB) on ADAM12 expression in RASFs from RA patients was examined by real-time RT-PCR. The effect of ADAM12 knock-down by ADAM12 siRNA and ADAM12 overexpression on cell proliferation of RASFs were examined by WST-1 assay. ADAM12 was identified predominantly in RA synovial tissue rather than OA and HC synovial tissues. Stimulation with TGF-β1 upregulated the expression of ADAM12 and cell proliferation of RASFs. ADAM12 siRNA suppressed TGF-β1-induced cell proliferation of RASFs, while ADAM12 overexpression promoted the cell proliferation of RASFs. These findings demonstrate that ADAM12 may have a key role in TGF-β1-induced cell proliferation of synovial fibroblasts in patients with RA. |
| Keywords | rheumatoid arthritis synovial tissue TGF-β1 ADAM12 cell proliferation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-04 |
| Volume | volume80 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 75 |
| End Page | 83 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
