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JaLCDOI 10.18926/40247
Title Alternative Studies on the Influences of Balneal Treatment on Female Sexual Function
FullText URL pitsr_025_025_052.pdf
Author Hasegawa, Yasumasa|
Abstract In the present study, observations of changes on female sexual function by balneal treatment were carried out with female rats with respects to sexual cycle, histological changes in ovary and uterus, histo-chemical changes in pituitary, cholinesterase activity in brain, cholesterol levels in ovary, etc. The results obtained were as follows. 1) Significant changes of sexual cycle appeared in 47 (62%) out of the 76 rats which were treated with several kinds of artificial balneal water at the temperature of 42°C (for 5 minutes per single course of the balneal treatment, twice daily during 4 weeks). Similar changes of sexual cycle also appeared in the subjects which were treated with the same kinds of balneal water at 37°C, though having showed to be less than the changes in case of the balneal treatment at 42°C. 2) A significant tendency of regulating sexual cycle of rat to normal was demonstrated in the subjects which were treated with artificial balneal sulfer, and on the other hand, a significant tendency of disturbing the cycle was demonstrated in the sUbjects which were treated with artificial balneal acid and alkali. 3) A tendency of extending the period of dioesterus phase in sexual cycle of rat was found in the subjects which were treated with our laboratory' balneal water at 42°C for 10 minutes per single course four times daily during 10 days. In these subjects, it was also demonstrated that the period of the estrus phase tended to be prolonged. 4) Histological pictures in ovary and uterus indicated normal growth in the subjects of which the sexual cycles were normalized by balneal treatment, whereas indicated an atrophy in the subjects of which the cycles were disturbed. Significant atrophy tended to appear remarkably in the subjects which developed some irregular cycles due to the treatment with artificial balneal acid or alkali. In view point of the daily changes in these tissues, it was demonstrated that atrophic changes appeared at the 10th day after onset of the treatment with a balneal water at 42°C for 5 minutes per single course or with a balneal water at 37°C for 5 minutes, and then turned to normal pictures at the 20th day after onset of the treatment. It was also indicated that remarkable atrophic changes in ovary and uterus appeared immediately after 10 days treatment with a balneal water at 42°C for 10 minutes per single course four times daily, and then turned to show a slight hyperfunction in the ovary at the 10th day after discontinuation of this balneal treatment. 5) A certain correlation was found between cholinesterase activity in the brain of rat and counts of PAS positive cells in the anterior pituitary (on the sexual zone named by Purves, H. D and W. E. Griesbach). Both the activity and the counts decreased at the 10th day after onset of the balneal treatment at the temperature of 42°C for 5 minutes per single course twice daily, and then increased at the 20th day after onset of this treatment. It was also demonstrated that both the activity and the counts decreased significantly at the 10th day after onset of the balneal treatment at 42°C for 10 minutes per single course four times daily, and then increased remarkably at the 10th day after discontinuation of this treatment. 6) A negative correlation was demonstrated between changes of cholesterol levels in ovary and those of cholinesterase activity in brain. Both the levels and the activity increased transitorily at the 10th day after the balneal treatment at 42°C for 5 minutes per single course, and then decreased at the 20th day after onset of the treatment. It was also demonstrated that both the activity and the levels increased at the 10th day after onset of the treatment at 42°C for 10 minutes per single course four times daily, and then decreased after discontinuation of this treatment. From the results mentioned above the following deduction may be drawn: (a) Sexual function is affected apparently by balneal treatment; (b) As to the mode of action of balneal water on sexual function, it is likely that balneal water acts extensively on autonomic nervous system, followed by producing changes in sexual function. In the other words, it seems that balneal water primarily affects on upper central nervous system, i. e. diencephalo-hypophyseo-system, and secondarily produces changes in sexual gland; (c) It was also demonstrated that though a transitory depression in sexual function appeared individually in some subjects which were treated with extensive stimulative balneal water or over time of balneal treatment, but in even the same subjects hyperfunction often appeared after discontinuation of such a treatment. These evidence should be taken into consideration in case of clinical balneotherapy; (d) In view point that the balneotherapy produces changes in sexual function through acting on central nervous system, it may be suggested that balneotherapy with conventional hormon therapy could produce the most desirous effect for the treatment of fertility and insufficiency of sexual function.
Publication Title 岡山大学温泉研究所報告
Published Date 1959-05
Volume volume25
Start Page 25
End Page 52
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002462888
JaLCDOI 10.18926/40246
Title Alternative Studies on the Chemical Composition and Levels of Ground Water at Misasa Hot Springs
FullText URL 025_013_024.pdf
Author Sakanoue, Masanobu|
Abstract The water levels of the thermal springs and the ground water levels were measured and the contour of the water table was obtained. The contour was disturbed at two regions in which many springs issue. The thermal and ground waters were sampled all over the springs district, and the water temperatures were measured when they were sampled. The chloride, bicarbonate, sulfate, calcium and magnesium content was also determined. In addition, the analytical methods for the determination of arsenic, phosphorus and acid-soluble iron were improved. Also the concentration of these elements was determined. Based on the results of the observations and chemical analysis, the relations between the water temperatures and content of chemical constituent and the chloride content were checked respectively. Positive correlations were found in the relations between water temperature~Cl(-), HCO(3)(-)~Cl(-), SO(4)(2-)~Cl(-), Ca(2+)~Cl(-), and As~Cl(-). Furthermore, the regional differences were detectable in the ratios of water temperature to chloride content and of bicarbonate to chloride content, nevertheless the correlation as a whole were valid. The diversity and regional differences of the chemical composition of the waters were explained as due to the differences in the mixing proportion of the magmatic thermal water and the varying kinds of ground water at the deep site in the ground and at the site near the ground surfaces.
Publication Title 岡山大学温泉研究所報告
Published Date 1959-05
Volume volume25
Start Page 13
End Page 24
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40244
language Japanese
File Version publisher
JaLCDOI 10.18926/40245
Title Alternative Granites in the Neighbourhood of Misasa Town, Tottori Prefecture
FullText URL pitsr_025_001_012.pdf
Author Shibata, Hidekata| Sayama, Mitsuo|
Publication Title 岡山大学温泉研究所報告
Published Date 1959-05
Volume volume25
Start Page 1
End Page 12
ISSN 0369-7142
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/40244
language Japanese
File Version publisher
NAID 120002462887
Author 岡山大学温泉研究所|
Published Date 1959-05
Publication Title 岡山大学温泉研究所報告
Volume volume25
Content Type Others
Author 岡山大学温泉研究所|
Published Date 1959-05
Publication Title 岡山大学温泉研究所報告
Volume volume25
Content Type Others
JaLCDOI 10.18926/40242
Title Alternative Clinical Studies on Anemia in Rheumatoid Arthritis (III)
FullText URL 026_050_063.pdf
Author Yamamoto, Yasuhisa|
Abstract III. The Effects of Balneotherapy and Antianemics on Anemia in Rheumatoid Arthritis 1. Balneotherapy: The author investigated the changes of the peripheral blood picture, erythrocyte sedimentation rate, numbers of finger-ring (Wheatsheaf's ring-test) and grasping power (by means of hand-dynamometer or sphygmometer) before and after baneotherapy. The regimen of spa treatment in our hospital includes bathing in radioactive hot spring (42-3°C. in temperature)two or three times a day, local mud bath or mud pack (once or twice a day, massage and drinking of spring water. These measures performed for one or two months. When the spa treatment has finished the erythrocyte count and Hb-content of rheumatoid patients increased in 61% of 33 cases examined comparing with before treatment, leucocyte count tended to shift to normal and E.S.R. decreased in 58% of the cases. The swelling of the finger joints diminished. 2. Oral iron therapy: In previous report, the author verified that there exist simple iron deficiency anemia in some cases of rheumatoid arthritis. Oral iron therapy responded well in such cases, but the majority of cases were resistant to oral iron. 3. Transfusion of blood in rheumatoid anemia: The author transfused 100 ml. of blood once a day for 5-10 days in 11 rheumatoid anemic patients. By the treatment of transfusion, the findings in peripheral blood improved and E.S.R. decreased.
Publication Title 岡山大学温泉研究所報告
Published Date 1959-10
Volume volume26
Start Page 50
End Page 63
ISSN 0369-7142
language Japanese
File Version publisher
JaLCDOI 10.18926/40241
Title Alternative Clinical Studies on Anemia in Rheumatoid Arthritis (II)
FullText URL 026_031_049.pdf
Author Yamamoto, Yasuhisa|
Abstract II. Iron Metabolism 1. The serum iron: The serum iron was estimated by the method of Umemoto and Yamamoto (by means of o-nitroso resorcinmonomethylether) The average serum iron level of 33 cases with rheumatoid arthritis was 47γ/100 ml., and in 27 of 33 cases (82%) the serum iron levels were shown to be below the lower limit of the normal range (5% rejection limit: 54-141γ/100 ml. ), but the concentrations of serum iron of neuralgias (degenerative Spondylosis, sciatica and painful shoulder) were mostly within the normal range. 2. Iron absorption: To investigate the possible role of poor absorption in preventing a response to oral iron therapy, the changes in serum iron were followed after a test of iron by mouth in 16 caseS with rheumatoid arthritis. The test dose was 1 gm. of reduced iron given with 30 mI. of lemonade-pepsin solution to preserve the iron in the ferrous state and obviate the effects of possible achlorhydria in rheumatoid patients. The results may be grouped under three headings: a) Large rise in serum iron: good adsorption. Three caseS (19%) showed a very large rise in serum iron after the test dose, which is similar to simple iron-deficiency anemia. b) Slight rise in serum iron: presumed poor absorption. Six cases (38%) showed a very small or negligible rise after the test dose, so that at its peak the serum iron was below the normal range. c) In the remaining 7 cases, a maximal rise in serum iron after the test dose was within the normal range. 3. The iron-binding capacity of the serum: The iron-binding capacity of the serum was estimated by means of intravenous injection of Gluferricon (Fe content: 10 mg.). The mean total iron-binding capacity of the serum in the present 13 cases with rheumatoid arthritis was 273γ/100ml., virtually the same as the normal figure (287γ /100 ml.). The degree of saturation of the iron-binding protein with iron was found to lie between 18 and 45% (average: 34%) in control sUbjects and between 7 and 24% (average: 16%) in rheumatoid patients. 4. The serum copper: The serum copper was estimated by means of diethyldithiocarbamate in rheumatoid arthritis with the following results. Healthy subjects: men (15 cases): mean 89.9±14.8γ /l00 ml., women (15 cases): mean 99.9± 12.6γ/100 ml. There is no significant difference between the two. In 10 of 17 cases (57%) with rheumatoid arthritis, the serum copper levels were shown to be above the upper limit of the normal range (57-138γ/100 ml. ・・・5% rejection limit), neuralgias were mostly (92%) within the normal range. The results of investigations upon alternations in iron metabolism of rheumatoid anemia are reported. 1. The serum iron concentration was usually reduced. 2. The intestinal absorption of iron after a single dose of 1 gm. of reduced iron was variable. Strong presumptive evidence of impaired absorption waS recognised in many cases, but some cases gave the excellent absorption. From these results, it seems that simple iron deficiency exist in some anemic caseS of rheumatoid arthritis. 3. The total iron-binding capacity of the serum was slightly reduced. 4. The degree of Saturation of iron-binding protein with iron was below nornal. 5. The serum copper concentration waS usually elevated.
Publication Title 岡山大学温泉研究所報告
Published Date 1959-10
Volume volume26
Start Page 31
End Page 49
ISSN 0369-7142
language Japanese
File Version publisher
JaLCDOI 10.18926/40240
Title Alternative Clinical Study on the Treatment of Rheumatoid Arthritis Part III. Experiences of Capsulosynovectomia Genu Anterior Totalis for Rheumatoid Arthritis
FullText URL 026_020_030.pdf
Author Izumi, Tomokuni|
Abstract Capsulosynovectomia genu anterior totalis was performed on five cases had marked hydrops and capsular thickening of joints, in which intraarticular injection of hydrocortisone or prednisolone, balneotherapy and hydrotherapy had been repeated in vain for long period with long standing pain and gradual decrease in motor function. The progress was observed for six to seventeen months after the operation, obtaining following results. Rheumatic symptoms were significantly improved after operation and restortion of function was also valuable. No exacerbations in the other joints and general condition were noted with rather improvement in the sign. Further, these operated joints became to react better, differ from preoperative, to balneotherapy and "Fango" with noticeable effects on the restoration of articular function. In histological findings of the resected synovia four cases showed Rs. and one Fr. by T. Kodama's classification. It is, therefore, recommended to appreciate this kind of operation on the cases shown no effects in the treatment of adrenocortical hormone or hot spring bath, which led to the decrease in gait ability, on the standpoint of medical rehabilitation.
Publication Title 岡山大学温泉研究所報告
Published Date 1959-10
Volume volume26
Start Page 20
End Page 30
ISSN 0369-7142
language Japanese
File Version publisher
JaLCDOI 10.18926/40239
Title Alternative Clinical Study on the Treatment of Rheumatoid Arthritis Part II. Experiences of Intraarticular Injection of Prednisolone for Rheumatoid Arthritis
FullText URL 026_008_019.pdf
Author Izumi, Tomokuni|
Abstract Meticorterone (Prednisolone acetate) were injected into joints of 33 cases of rheumatoid arthritis, 172 times in total, with better results. Although intraarticular injection of prednisolone is, at present, to be one of the most effective treatment for rheumatoid arthritis, one must pay attention at the appearance of general effect in frequent and abundant injection. Comparative studies were performed on the effects of intraarticular injectons of prednisolone T. B. A, (on twelve cases), hydrocortisone acetate and meticorterone. Prednisolone T. B. A. was proved markedly longer effect in local with minimum general effect, It was, therefore, thought that prednisolone T. B. A. was safest and most effective in intraarticular therapy on the rheumatoid arthritis.
Publication Title 岡山大学温泉研究所報告
Published Date 1959-10
Volume volume26
Start Page 8
End Page 19
ISSN 0369-7142
language Japanese
File Version publisher
JaLCDOI 10.18926/40238
Title Alternative Clinical Study on the Treatment of Rheumatoid Arthritis Part I. Therapeutic Experiences by Hot Spring Bath and "Fango" using Clay of Nigyo-pass
FullText URL pitsr_026_001_007.pdf
Author Izumi, Tomokuni|
Abstract Rheumatoid arthritis, thought incurable for many years, was treated by radioactive hot spring bath and uranium deposit clay at Ningyo-pass. The therapeutic effects of balneotherapy and "Fango" were stUdied comparatively. Results of hot spring bath for one month were effective in 63 of 73 cases (86.3 per cent), and 60 per cent even in (222) chr., in which attaind Grade III. It was thought that therapeutic effect of bathing on (222) chr. was increased using together with adrenocortical hormone. Uranium deposit clay at Ningyo-pass was used on 59 cases of this disease, in form of "Fango" and local bath in mud. It was effective in 60.8 per cent of 171 joints, and in 53.4 per cent of 131 joints of (222) chr. It showed that this was valuable as a local therapy for those incurable types of the disease.
Publication Title 岡山大学温泉研究所報告
Published Date 1959-10
Volume volume26
Start Page 1
End Page 7
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002462886
Author 岡山大学温泉研究所|
Published Date 1959-10
Publication Title 岡山大学温泉研究所報告
Volume volume26
Content Type Others
JaLCDOI 10.18926/40236
Title Alternative Geochemical Studies on the Area of Hot Springs in Hamamura and Shikano District Comparison of Characteristics of Hot Springs in the Central part of Tottori Prefecture, Japan
FullText URL 027_025_044.pdf
Author Sakanoue, Masanobu| Mifune, Masaaki|
Abstract The thermal and ground waters were sampled in the hot springs district of Hamamura-Katsumi and Shikano and in their neighborhoods. The water temperatures were measured when they were sampled. Among the major chemical constituents, the chloride, sulfate, bicarbonate (methyl-orange alkalinity), calcium and magnesium content was determined. Furthermore, as the minor constituents, the arsenic and phosphorus content was also determined. The uranium, radium and radon content was determined in some samples of hot springs. Based on the results of chemical analysis, the relations between the chloride content and the content of other chemical constituents were cheked respectively. Positive correlations were found in the relations between water temperature-Cl(-), SO(4)(2-)-Cl(-), Ca(2+)-Cl(-) and As-Cl(-), although the ratios of each content showed the different characteristic in Hamamura-Katsumi compared with that in Shikano. In the samples of Hamamura-Katsumi where the thermal waters were pumped out from the sedimentary beds of volcanic rocks, the sulfate and calcium content was relatively richer compared with the content of these ions in the samples of Shikano where granitic rocks underlay as the basement in the fairly shallow depth from the cground surface. These characteristics were also noticed when the chemical compositions of other hot springs in the central part of Tottori prefecture were examined. In the neighborhood of the hot springs district mentioned-above, distinctive indications of hot spring were found at Kinashi which was placed between Hamamura and Shikano, comprehensively examining the content of chemical constituents in the ground water samples in this region.
Publication Title 岡山大学温泉研究所報告
Published Date 1961-01
Volume volume27
Start Page 25
End Page 44
ISSN 0369-7142
language Japanese
File Version publisher
NAID 40017532371
JaLCDOI 10.18926/40235
FullText URL pitsr_027_011_023.pdf
Author 杉山 隆二|
Publication Title 岡山大学温泉研究所報告
Published Date 1961-01
Volume volume27
Start Page 11
End Page 23
ISSN 0369-7142
language Japanese
File Version publisher
NAID 120002462885
JaLCDOI 10.18926/40234
FullText URL pitsr_027_001_009.pdf
Author Sakanoue, Masanobu|
Abstract In recent years, coulometric analysis has been developed and widely used as a technique for the determination of substances in solution by measuring the quantity of electricity required for the completion of a reaction in an electrolysis cell. Of two coulometric techniques, i. e., coulometric titration with a constant current and coulometric analysis with a controlled potential of a working electrode, the latter is more interesting to the author, because by this method both electrolytic separation and quantitative determination of chemical species can be achieved simultaneously. Especially, the use of a mercury cathode as the working electrode(1)) has an advantage that the optimum control potentials can easily be determinable from polarographic data. In our laboratory, we took up the coulometry of uranium as one of the interesting themes of researches when we had an opPortunity in studying various kinds of analytical methods for uranium in accordance with the request by Japan Atomic Fuel Corporation. The coulometric determination of uranium (VI) by using a mercury cathode at a controlled potential was studied by G. L. Booman, W. B. Holbrook and ]. E. Rein(2)). It was found to be very useful for the analysis of uranium in a highly enriched nuclear element which underwent fission to an appreciable extent. But the instrument used by them(3)) was complicated and expensive. Therefore, a simple counter millicoulometer has been coustructed in our laboratory, a readymade potentiostat (electrical instrument for automatic controlled potential electrolysis) being tried for electrolysis. By these instruments, the author studied the fundam ental conditions of coulometry for uranium and tried the successive determinations of uranium and thallium in mixed solutions.
Publication Title 岡山大学温泉研究所報告
Published Date 1961-01
Volume volume27
Start Page 1
End Page 9
ISSN 0369-7142
language English
File Version publisher
NAID 120002462884
Author 岡山大学温泉研究所|
Published Date 1961-01
Publication Title 岡山大学温泉研究所報告
Volume volume27
Content Type Others
Author 森永 寛|
Published Date 1961-03
Publication Title 岡山大学温泉研究所報告
Volume volume28
Content Type Others
Author Institute for Thermal Spring Research, Okayama University|
Published Date 1961-03
Publication Title 岡山大学温泉研究所報告
Volume volume28
Content Type Others
Author Institute for Thermal Spring Research, Okayama University|
Published Date 1961-03
Publication Title 岡山大学温泉研究所報告
Volume volume28
Content Type Others
JaLCDOI 10.18926/40229
FullText URL 028_008_012.pdf
Author 森永 寛|
Publication Title 岡山大学温泉研究所報告
Published Date 1961-03
Volume volume28
Start Page 8
End Page 12
ISSN 0369-7142
language Japanese
File Version publisher
NAID 40018217662
Author 八木 日出雄|
Published Date 1961-03
Publication Title 岡山大学温泉研究所報告
Volume volume28
Content Type Presentation