| ID | 69136 |
| FullText URL | |
| Author |
Miyano, Ryoji
Department of Neurology, Graduate School of Medicine, The University of Tokyo
Mitsutake, Akihiko
Department of Neurology, Graduate School of Medicine, The University of Tokyo
Matsukawa, Takashi
Department of Neurology, Graduate School of Medicine, The University of Tokyo
Obata, Satomi
Department of Neurology, Graduate School of Medicine, The University of Tokyo
Koyama, Hiroaki
Department of Radiology, Graduate School of Medicine, The University of Tokyo
Nakai, Yudai
Department of Radiology, Graduate School of Medicine, The University of Tokyo
Ishiura, Hiroyuki
Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kubota, Akatsuki
Department of Neurology, Graduate School of Medicine, The University of Tokyo
Shimizu, Jun
Department of Neurology, Graduate School of Medicine, The University of Tokyo
Sakuishi, Kaori
Department of Neurology, Graduate School of Medicine, The University of Tokyo
Toda, Tatsushi
Department of Neurology, Graduate School of Medicine, The University of Tokyo
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| Abstract | We herein report a 26-year-old man diagnosed with Wilson's disease (WD), initially treated for schizophrenia for 11 years. At 26 years old, he was admitted because of status epilepticus. Brain magnetic resonance imaging revealed frontal-dominant leukoencephalopathy with cystic changes and basal ganglia atrophy. The diagnosis of WD was confirmed based on neuropsychiatric symptoms, Kayser-Fleischer rings, abnormal copper metabolism, and a genetic analysis of ATP7B. Psychotic symptoms in WD can precede neurological manifestations, and extrapyramidal signs may be mistaken for drug-induced Parkinsonism. WD should be considered in patients presenting with progressive Parkinsonism preceded by schizophrenia-like psychiatric symptoms.
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| Keywords | Wilson’s disease
leukoencephalopathy
brain MRI
ATP7B
schizophrenia
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| Published Date | 2025-07-15
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| Publication Title |
Internal Medicine
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| Volume | volume64
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| Issue | issue14
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| Publisher | Japanese Society of Internal Medicine
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| Start Page | 2240
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| End Page | 2244
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| ISSN | 0918-2918
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| NCID | AA10827774
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| Copyright Holders | © 2025 by The Japanese Society of Internal Medicine
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| File Version | publisher
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| PubMed ID | |
| DOI | |
| CRID | |
| Web of Science KeyUT | |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.4353-24
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| License | https://creativecommons.org/licenses/ by-nc-nd/4.0/
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