| ID | 16449 |
| Eprint ID | 16449
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| FullText URL | |
| Title Alternative | Studies on antibody-anticancer drug conjugate Part 2. In vivo antitumor activity of anti-Ia monoclonal antibody-Neocarzinostatin conjugate
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| Author |
Okazaki, Morihiro
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| Abstract | In vivo antitumor activity of anti-Ia monoclonal IgM antibody (H-2)-Neocarzinostatin (NCS) conjugate (H-2-NCS) was evaluated in immunosuppressed newborn hamsters implanted with a transplantable human leukemia cell line (BALL-1). After intraperitoneal injection of H-2-NCS, hamsters preinoculated i.p. with BALL-1 cells survived longer than hamsters treated with control solutions (p<0.001). The control solutions included nonimmune monoclonal IgM-NCS conjugate, H-2 antibody, free NCS and phosphatebuffered saline. Growth inhibition of subcutaneously implanted BALL-1 tumors was not observed in hamsters injected i.p. with H-2-NCS or H-2 monomer subunit antibody-NCS conjugate. These results indicate that H-2-NCS was effective against i.p. implanted BALL-1 tumors, but was not effective against s.c. implanted tumors.
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| Keywords | Monoclonal antibody-Neocarzinostatin conjugate
Transplantable human leukemia cells
In vivo antitumor activity
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| Published Date | 1984-04-30
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume96
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| Issue | issue5-6
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 623
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| End Page | 629
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/96/5-6/96_5-6_623/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
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