| ID | 14509 |
| Eprint ID | 14509
|
| FullText URL | |
| Title Alternative | Oncogene mRNA in gastric cancer by in situ hybridization by using a biotin-labeled probe
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| Author |
Tanaka, Izuru
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| Abstract | Expression of oncogene mRNA in gastric cancer was studied by in situ hybridization. Cancer tissues were fixed in formalin and embeded in paraffin. Then, DNA-mRNA hybridization was performed by using two biotin-labeled cDNA probes (c-myc, c-Ha ras).
Oncogene mRNA was intracuelularly localized, mainly in the cytoplasm, and also found in the nucleus of partial cells. Higher concentrations of oncogene mRNA vere found in advanced cancers than in early cancers, and in metastatic positive cases of the above n2 than of n0 or n1.
This suggests that the expression of oncogene mRNA is related to the malignant potency of cancer.
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| Keywords | histo in situ hybridization 法
胃癌
癌遺伝子
ｍRNA
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| Note | 原著
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| Published Date | 1991
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume103
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| Issue | issue4
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 247
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| End Page | 255
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/103/4/103_4_247/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/
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| language |
Japanese
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| Copyright Holders | 岡山医学会
|
| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
|
