| ID | 11542 |
| JaLCDOI | |
| Sort Key | 13
|
| Title Alternative | Preparation and In Vitro Release Property of PLA Microspheres Enclosing Antitumor Agent
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| FullText URL | |
| Author |
Nishino, Satoru
Yoshizawa, Hidekazu
Natsugoe, Shoji
Aiko, Takashi
Hatate, Yasuo
Kitamura, Yoshiro
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| Abstract | Recently, many antitumor agents developed. Irinotecan hycrochloride (CPT) has a great side effect even though it is well effective against the cancer. Drug delivery system (DDS) medicine indicates that the release rate of medicine is constant for a long time. Therefore, in order to materialize the general idea of DDS, we applied microencapsulation technique to prepare biodegradable polymer microspheres (MS) enclosing antitumor drug having no side effect. Polylactide microparticles enclosing antitumor agent were prepared by solvent evaporation method under various operation conditions. The effects of operation parameter on release rate of drug and morphology of microparticles were studied.
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| Keywords | DDS
microparticle
polylactide
antitumor agent
solvent evaporation
DSC
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| Publication Title |
岡山大学環境理工学部研究報告
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| Published Date | 2001-02-28
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| Volume | volume6
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| Issue | issue1
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| Publisher | 岡山大学環境理工学部
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| Publisher Alternative | Faculty of Environmental Science and Technology, Okayama University
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| Start Page | 103
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| End Page | 106
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| ISSN | 1341-9099
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| NCID | AN10529213
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| Content Type |
Departmental Bulletin Paper
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| OAI-PMH Set |
岡山大学
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| language |
Japanese
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| File Version | publisher
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| NAID | |
| Eprints Journal Name | fest
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