start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue= article-no= start-page=113544 end-page=113556 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Optimized Ensemble Deep Learning for Real-Time Intrusion Detection on Resource-Constrained Raspberry Pi Devices en-subtitle= kn-subtitle= en-abstract= kn-abstract=The rapid growth of Internet of Things (IoT) networks has increased security risks, making it essential to have effective Intrusion Detection Systems (IDS) for real-time threat detection. Deep learning techniques offer promising solutions for such detection due to their superior complex pattern recognition and anomaly detection capabilities in large datasets. This paper proposes an optimized ensemble-based IDS designed specifically for efficient deployment on edge hardware. However, deploying such computationally intensive models on resource-limited edge devices remains a significant challenge due to model size and computational overhead on devices with limited processing capabilities. Building upon our previously developed stacked Long Short-Term Memory (LSTM) model integrated with ANOVA feature selection, we optimize it by integrating dual-stage model compression: pruning and quantization to create a lightweight model suitable for real-time inference on Raspberry Pi devices. To evaluate the system under realistic conditions, we combined with a Kafka-based testbed to simulate dynamic IoT environments with variable traffic loads, delays, and multiple simultaneous attack sources. This enables the assessment of detection performance under varying traffic volumes, latency, and overlapping attack scenarios. The proposed system maintains high detection performance with accuracy of 97.3% across all test scenarios, while efficiently leveraging multi-core processing with peak CPU usage reaching 111.8%. These results demonstrate the system’s practical viability for real-time IoT security at the edge. en-copyright= kn-copyright= en-aut-name=MusthafaMuhammad Bisri en-aut-sei=Musthafa en-aut-mei=Muhammad Bisri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HudaSamsul en-aut-sei=Huda en-aut-mei=Samsul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NguyenTuy Tan en-aut-sei=Nguyen en-aut-mei=Tuy Tan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KoderaYuta en-aut-sei=Kodera en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NogamiYasuyuki en-aut-sei=Nogami en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Interdisciplinary Education and Research Field, Okayama University kn-affil= affil-num=3 en-affil=School of Informatics, Computing, and Cyber Systems, Northern Arizona University kn-affil= affil-num=4 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Internet of things kn-keyword=Internet of things en-keyword=intrusion detection system kn-keyword=intrusion detection system en-keyword=stacked lstm kn-keyword=stacked lstm en-keyword=pruning model kn-keyword=pruning model en-keyword=optimizing model kn-keyword=optimizing model en-keyword=quantization model kn-keyword=quantization model en-keyword=raspberry pi kn-keyword=raspberry pi en-keyword=real-time detection kn-keyword=real-time detection en-keyword=apache kafka kn-keyword=apache kafka END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue= article-no= start-page=89003 end-page=89024 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250519 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Security in Post-Quantum Era: A Comprehensive Survey on Lattice-Based Algorithms en-subtitle= kn-subtitle= en-abstract= kn-abstract=Lattice-based post-quantum cryptography (PQC) has attracted significant attention as a promising solution to the security challenges posed by quantum computing. Unlike traditional cryptographic algorithms, lattice-based schemes are expected to remain secure even in the presence of quantum attacks, making them essential for securing future data. Despite their strong theoretical foundations, lattice-based schemes face several practical challenges, particularly in optimizing performance and scalability for real-world applications. This survey provides a novel taxonomy that categorizes lattice-based PQC designs, with an emphasis on computational paradigms and security considerations. We systematically evaluate lattice-based PQC implementations across both software platforms, including central processing units and graphics processing units, as well as hardware platforms like field-programmable gate arrays and application-specific integrated circuits, highlighting their strengths and limitations. In addition, we explore the practical applications of lattice-based cryptography in fields such as secure communication, critical infrastructure, privacy-preserving data analytics, artificial intelligence, and trust and authentication systems. By offering a comprehensive overview of the current state of lattice-based PQC, this survey aims to provide valuable insights into the ongoing advancements and future research directions in the field as we transition to a post-quantum era. en-copyright= kn-copyright= en-aut-name=NguyenHien en-aut-sei=Nguyen en-aut-mei=Hien kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HudaSamsul en-aut-sei=Huda en-aut-mei=Samsul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NogamiYasuyuki en-aut-sei=Nogami en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NguyenTuy Tan en-aut-sei=Nguyen en-aut-mei=Tuy Tan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=School of Informatics, Computing, and Cyber Systems, Northern Arizona University kn-affil= affil-num=2 en-affil=Interdisciplinary Education and Research Field, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=School of Informatics, Computing, and Cyber Systems, Northern Arizona University kn-affil= en-keyword=Post-quantum cryptography kn-keyword=Post-quantum cryptography en-keyword=lattice-based cryptography kn-keyword=lattice-based cryptography en-keyword=number theoretic transform kn-keyword=number theoretic transform en-keyword=hardware and software implementation kn-keyword=hardware and software implementation END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=4 article-no= start-page=401 end-page=409 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=High-Definition Topographic Archiving and Educational Applications in Regions Affected by the 2024 Noto Peninsula Earthquake en-subtitle= kn-subtitle= en-abstract= kn-abstract=The 2024 Noto Peninsula earthquake (Mw 7.5) caused extensive damage in Ishikawa Prefecture, Japan, and surrounding areas, with considerable coastal uplift and tsunami flooding. Past 100 years’ records show no earthquake above Mw 7.0 in the Noto Peninsula, so for everyone alive today, this event is truly without precedent. Therefore, we aimed to support disaster prevention education by developing teaching materials using unmanned aerial vehicles (UAVs) based on digitally archived topographic changes. High-definition topographic data collected from multiple UAV surveys were processed into digital and analog formats, including 3D models, spherical panorama images, and 3D printings. These materials were designed to provide detailed and intuitive representations of post-disaster landforms and were used as educational tools in schools. The learning materials were introduced during a workshop for disaster-affected teachers, featuring hands-on activities to help participants familiarize themselves with the materials, and explore their integration into geography and science classes. Feedback from participants indicated that these tools were highly effective in enhancing classroom learning. The results of this study are expected to contribute to preserving disaster records while enhancing disaster awareness in educational settings and local communities. en-copyright= kn-copyright= en-aut-name=OguraTakuro en-aut-sei=Ogura en-aut-mei=Takuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamauchiHiroyuki en-aut-sei=Yamauchi en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AokiTatsuto en-aut-sei=Aoki en-aut-mei=Tatsuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MattaNobuhisa en-aut-sei=Matta en-aut-mei=Nobuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IizukaKotaro en-aut-sei=Iizuka en-aut-mei=Kotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IwasaYoshiya en-aut-sei=Iwasa en-aut-mei=Yoshiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakahashiTakayuki en-aut-sei=Takahashi en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HayashiKiyomi en-aut-sei=Hayashi en-aut-mei=Kiyomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HattanjiTsuyoshi en-aut-sei=Hattanji en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OguchiTakashi en-aut-sei=Oguchi en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Graduate School of Education, Hyogo University of Teacher Education kn-affil= affil-num=2 en-affil=Art Research Center, Ritsumeikan University kn-affil= affil-num=3 en-affil=Faculty of Regional Development Studies, Kanazawa University kn-affil= affil-num=4 en-affil=Graduate School of Education, Okayama University kn-affil= affil-num=5 en-affil=Center for Spatial Information Science, The University of Tokyo kn-affil= affil-num=6 en-affil=Faculty of Education, University of Teacher Education Fukuoka kn-affil= affil-num=7 en-affil=International Research Institute of Disaster Science, Tohoku University kn-affil= affil-num=8 en-affil=Faculty of Regional Development Studies, Kanazawa University kn-affil= affil-num=9 en-affil=Institute of Life and Environmental Sciences, University of Tsukuba kn-affil= affil-num=10 en-affil=Center for Spatial Information Science, The University of Tokyo kn-affil= en-keyword=disaster risk-reduction education kn-keyword=disaster risk-reduction education en-keyword=uplift area kn-keyword=uplift area en-keyword=UAV kn-keyword=UAV en-keyword=3D printing kn-keyword=3D printing END start-ver=1.4 cd-journal=joma no-vol=37 cd-vols= no-issue=1 article-no= start-page=43 end-page=53 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250220 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Fan-Shaped Pneumatic Soft Actuator that Can Operate Bending Motion for Ankle-Joint Rehabilitation Device en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nowadays, owing to declining birthrates and an aging population, patients and the elderly requiring rehabilitation are not getting enough physical activity. In addressing this issue, devices for rehabilitating them have been researched and developed. However, rehabilitation devices are almost exclusively used for patients who can get up, rather than those who are bedridden. In this study, we aim to develop a rehabilitation device that can provide passive exercise for bedridden patients. The ankle joint was selected as the target joint because the patients who have undergone surgery for cerebrovascular disease remain bedridden, and early recovery in the acute stage is highly desirable. We proposed and tested a fan-shaped pneumatic soft actuator (FPSA) that can expand and bend stably at angles when supply pressure is applied as an actuator for a rehabilitation device to encourage patient exercise. However, the previous FPSA’s movement deviates from the arch of the foot owing to increased supply pressure. In the ideal case, FPSA should push the arch of the foot in an arc motion. This study proposes and tests the FPSA that can operate a bending motion to provide passive exercise to the ankle joint using tensile springs and a winding mechanism powered by a servo motor. The proposed FPSA has a significant advantage of exhibiting no hysteresis in its pressure-displacement characteristics. The configuration and static analytical model of the improved FPSA are described. en-copyright= kn-copyright= en-aut-name=ShimookaSo en-aut-sei=Shimooka en-aut-mei=So kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YokoyaHirosato en-aut-sei=Yokoya en-aut-mei=Hirosato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HamadaMasanori en-aut-sei=Hamada en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShiomiShun en-aut-sei=Shiomi en-aut-mei=Shun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=UeharaTakenori en-aut-sei=Uehara en-aut-mei=Takenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HirayamaTakahiro en-aut-sei=Hirayama en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KamegawaTetsushi en-aut-sei=Kamegawa en-aut-mei=Tetsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=3 en-affil=Department of Rehabilitation Medicine, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Rehabilitation Medicine, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Orthopaedic Surgery, NHO Okayama Medical Center kn-affil= affil-num=6 en-affil=Department of Emergency, Critical Care and Disaster Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=fan-shaped pneumatic soft actuator kn-keyword=fan-shaped pneumatic soft actuator en-keyword=ankle-joint rehabilitation device kn-keyword=ankle-joint rehabilitation device en-keyword=hysteresis kn-keyword=hysteresis en-keyword=range of motion kn-keyword=range of motion END start-ver=1.4 cd-journal=joma no-vol=79 cd-vols= no-issue=4 article-no= start-page=231 end-page=242 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202508 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Bloodstream Infections Caused by Gram-Negative Bacteria in Geriatric Patients: Epidemiology, Antimicrobial Resistance and The Factors Affecting Mortality en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bloodstream infections (BSIs) are an important cause of morbidity and mortality in geriatric patients. We retrospectively analyzed the cases of geriatric patients who developed BSIs due to gram-negative bacteria in order to evaluate the epidemiology, antimicrobial resistance, and the factors affecting mortality. The cases of 110 patients aged ≥ 65 years admitted to our hospital between January 1, 2017, and December 31, 2022 were assessed; 70 (63.6%) of the BSIs were healthcare-associated BSIs. The urinary system was the most common detectable source of infection at 43.6%. The most frequently isolated bacteria were Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae, in that order. Carbapenem resistance was detected in 17 patients (15.5%), and extended-spectrum beta-lactamase (ESBL) production from Enterobacterales family members was detected in 37 (51.4%) patients. Multivariate analysis revealed that (i) the probability of mortality in the patients with total bilirubin was increased by approx. sixfold and (ii) the likelihood of mortality for those with a Pitt bacteremia score (PBS) ≥ 4 points was approx. 17 times higher. PBS and simplified qPitt scores can help predict mortality and manage geriatric patients. There is a significant increase in mortality among patients with procalcitonin (PCT) levels at ≥ 2 nm/ml. en-copyright= kn-copyright= en-aut-name=KardanM Enes en-aut-sei=Kardan en-aut-mei=M Enes kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ErdemIlknur en-aut-sei=Erdem en-aut-mei=Ilknur kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YildizEmre en-aut-sei=Yildiz en-aut-mei=Emre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KirazNuri en-aut-sei=Kiraz en-aut-mei=Nuri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ÇelikkolAliye en-aut-sei=Çelikkol en-aut-mei=Aliye kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Infectious Diseases, Faculty of Medicine, Namik Kemal University kn-affil= affil-num=2 en-affil=Department of Infectious Diseases, Faculty of Medicine, Namik Kemal University kn-affil= affil-num=3 en-affil=Department of Infectious Diseases, Faculty of Medicine, Namik Kemal University kn-affil= affil-num=4 en-affil=Department of Medical Microbiology, Faculty of Medicine, Namik Kemal University kn-affil= affil-num=5 en-affil=Department of Biochemistry, Faculty of Medicine, Namik Kemal University kn-affil= en-keyword=geriatrics kn-keyword=geriatrics en-keyword=gram-negative bacteria kn-keyword=gram-negative bacteria en-keyword=epidemiology kn-keyword=epidemiology en-keyword=antimicrobial resistance kn-keyword=antimicrobial resistance en-keyword=mortality kn-keyword=mortality END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=3 article-no= start-page=337 end-page=345 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250505 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Study on the Grinding Temperature of Workpiece in Side Plunge Grinding Process en-subtitle= kn-subtitle= en-abstract= kn-abstract=Grinding is used to finish thrust metal attachment parts, such as crankshafts, which have both journal and thrust surfaces. In side plunge grinding, a thrust surface and a cylindrical surface of a shaft workpiece with collars are finished in a single plunge grinding process. However, the surface quality near the ground internal corner, where grinding fluid may not penetrate, can deteriorate, causing high residual stress and cracks owing to grinding heat. While it has been reported that quality issues at the inner corners of the ground surface can be mitigated by reducing the grinding point temperature through efficient cooling fluid supply, the mechanisms of grinding phenomena and heat generation in side plunge grinding are not yet fully understood. In this study, the variations in the grinding temperature at the thrust surface of a workpiece with a collar were experimentally investigated using a wire/workpiece thermocouple to clarify these phenomena. The results revealed a significant increase in the grinding temperature at the corners of the grinding zone. However, it slightly decreases as the thermocouple output approaches the center of the workpiece, indicating a slight effect of the grinding speed. The surface temperature of the workpiece in side plunge grinding is primarily influenced by the wheel depth-of-cut in the thrust direction. Additionally, the effect of workpiece rotational speed and grinding infeed speed on temperature distribution has been demonstrated. en-copyright= kn-copyright= en-aut-name=GaoLingxiao en-aut-sei=Gao en-aut-mei=Lingxiao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KuidaMotoki en-aut-sei=Kuida en-aut-mei=Motoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KodamaHiroyuki en-aut-sei=Kodama en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhashiKazuhito en-aut-sei=Ohashi en-aut-mei=Kazuhito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=grinding kn-keyword=grinding en-keyword=thrust surface kn-keyword=thrust surface en-keyword=grinding temperature kn-keyword=grinding temperature en-keyword=thermocouple kn-keyword=thermocouple END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=292 end-page=297 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231127 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Analyzing Post-injection Attacker Activities in IoT Devices: A Comprehensive Log Analysis Approach en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the continuous proliferation of Internet of Things (IoT) devices, malware threats that specifically target these devices continue to increase. The urgent need for robust security measures is predicated on a comprehensive understanding of the behavioral patterns of IoT malware. However, previous studies have often overlooked the analysis of command sequences in Telnet logs. This study bridges this research gap by examining the post-injection behaviors of attackers. By analyzing a vast dataset comprising more than ten million logs collected from an IoT honeypot, we reveal three distinct post-injection activity patterns, each with unique characteristics. These patterns provide pivotal insights that not only help distinguish between legitimate operations and attempted attacks, but also drive the development of robust cybersecurity measures that effectively deter such behaviors. The nuances discovered in this study contribute significantly to IoT security by enhancing our understanding of malware tactics and informing targeted defense strategies. en-copyright= kn-copyright= en-aut-name=VictorHervet en-aut-sei=Victor en-aut-mei=Hervet kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KobayashiSatoru en-aut-sei=Kobayashi en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamauchiToshihiro en-aut-sei=Yamauchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Okayama University kn-affil= affil-num=2 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Malware analysis kn-keyword=Malware analysis en-keyword=IoT kn-keyword=IoT en-keyword=Honeypot kn-keyword=Honeypot en-keyword=Log analysis kn-keyword=Log analysis en-keyword=Attack patterns kn-keyword=Attack patterns END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=274 end-page=278 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231127 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prevention Method for Stack Buffer Overflow Attack in TA Command Calls in OP-TEE en-subtitle= kn-subtitle= en-abstract= kn-abstract=TEE systems provide normal world and secure world. It is impossible to gain access to the secure world directly from the normal world. However, vulnerabilities in the secure world can cause attacks to compromise the secure world. In this study, we investigate the security features applied to trusted applications (TA) in OP-TEE and clarify the lack of protection against stack buffer overflow in TA command calls. We also propose a method for preventing attacks that exploit stack buffer overflows in TA command calls. In addition, the experimental results show that attacks on the vulnerable TAs can be prevented with the proposed method and the overhead can be evaluated. en-copyright= kn-copyright= en-aut-name=ShibaKaito en-aut-sei=Shiba en-aut-mei=Kaito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KuzunoHiroki en-aut-sei=Kuzuno en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamauchiToshihiro en-aut-sei=Yamauchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Engineering, Kobe University kn-affil= affil-num=3 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Trusted execution environment kn-keyword=Trusted execution environment en-keyword=Stack overflow prevention method kn-keyword=Stack overflow prevention method en-keyword=System security kn-keyword=System security END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=161 end-page=167 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231128 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evaluation of Effectiveness of MAC Systems Based on LSM for Protecting IoT Devices en-subtitle= kn-subtitle= en-abstract= kn-abstract=Numerous active attacks targeting Internet of Things (IoT) devices exist. They exploit the latest vulnerabilities discovered in IoT devices. Therefore, Mandatory Access Control (MAC) systems based on Linux Security Modules (LSM), such as SELinux and AppArmor, are effective security features for IoT devices because they can mitigate the impact of attacks even if software vulnerabilities are discovered. However, they are not adopted by most IoT devices. The existing approaches are insufficient for investigating the causes of this problem.In this study, we comprehensively investigated what factors can affect the applicability of MAC systems based on LSM in IoT devices. We focused on how frequently cases can occur where they cannot be adopted, owing to each factor. To increase the comprehensiveness of the factors affecting the adoption of MAC systems in IoT devices, we investigated the kernel version, CPU architecture, and support for BusyBox in addition to the investigation of resources, which conducted in previous studies. We also conducted simulated experiments based on the attack method of Mirai to investigate whether MAC systems can protect against IoT malware. Finally, we discuss the impact of a combination of these factors on MAC system adoption. en-copyright= kn-copyright= en-aut-name=MikiMasato en-aut-sei=Miki en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamauchiToshihiro en-aut-sei=Yamauchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KobayashiSatoru en-aut-sei=Kobayashi en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Mandatory Access Control System kn-keyword=Mandatory Access Control System en-keyword=IoT Security kn-keyword=IoT Security en-keyword=Linux Security Modules kn-keyword=Linux Security Modules END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=236 end-page=244 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230623 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Non Real-Time Data Transmission Performance Analysis of PROFINET for Assuring Data Transmission Quality en-subtitle= kn-subtitle= en-abstract= kn-abstract=The industrial Ethernet PROFINET supports three different data transmission modes: isochronous real-time (IRT), real-time (RT), and non real-time (NRT) transmitting data requiring hard, soft, and no real-time performances, respectively. The data transmission latency in the NRT increased with the amount of data transmission in the IRT, RT, and NRT. Therefore, the quality of data transmission in NRT may degrade as the amount of data transmission in IRT, RT, and NRT increases. In this study, we derived the average data transmission latency in an NRT with data transmission in IRT and RT by applying stochastic processes. This allowed us to maintain the quality of data transmission in the NRT by adjusting the number of devices connected to the network and the number of applications transmitting data in the NRT so that the average latency of data in the NRT does not exceed a certain value. en-copyright= kn-copyright= en-aut-name=NorimatsuTakashi en-aut-sei=Norimatsu en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamauchiToshihiro en-aut-sei=Yamauchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Industrial Ethernet kn-keyword=Industrial Ethernet en-keyword=PROFINET kn-keyword=PROFINET en-keyword=Non Real Time kn-keyword=Non Real Time en-keyword=Real-Time kn-keyword=Real-Time en-keyword=Isochronous Real Time kn-keyword=Isochronous Real Time END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=267 end-page=273 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231127 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Supporting Multiple OS Types on Estimation of System Call Hook Point by Virtual Machine Monitor en-subtitle= kn-subtitle= en-abstract= kn-abstract=Methods to hook system calls issued by a guest operating system (OS) running on a virtual machine using a virtual machine monitor are proposed. The address of the hook point is derived from the guest OS’s source code and established prior to the kernel startup process. Due to changes in system call processing in OS updates and address space layout randomization, the addresses of these hook points cannot always be pre-determined before the kernel startup process. To address this challenge, a method for estimating the system call hook point is proposed in Linux by analyzing the guest OS memory on x86-64 CPUs rather than pre-calculation. Although the method supports Linux, the method can be extended to support other OS types. In this paper, we propose a method to extend the method to support additional OSes. Specifically, we present analysis results and a novel method for estimating hook points on FreeBSD, NetBSD, and OpenBSD. The effectiveness of our proposed method is also demonstrated through evaluation. en-copyright= kn-copyright= en-aut-name=SatoMasaya en-aut-sei=Sato en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OmoriTaku en-aut-sei=Omori en-aut-mei=Taku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamauchiToshihiro en-aut-sei=Yamauchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TaniguchiHideo en-aut-sei=Taniguchi en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Okayama Prefectural University kn-affil= affil-num=2 en-affil=Okayama Prefectural University kn-affil= affil-num=3 en-affil=Okayama University kn-affil= affil-num=4 en-affil=Okayama University kn-affil= en-keyword=system call kn-keyword=system call en-keyword=virtual machine monitor kn-keyword=virtual machine monitor en-keyword=operating system kn-keyword=operating system END start-ver=1.4 cd-journal=joma no-vol=79 cd-vols= no-issue=1 article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202502 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Endothelial Cell Polarity in Health and Disease en-subtitle= kn-subtitle= en-abstract= kn-abstract=Endothelial cell polarity is fundamental to the organization and function of blood vessels, influencing processes such as angiogenesis, vascular stability, and response to shear stress. This review elaborates on the molecular mechanisms that regulate endothelial cell polarity, focusing on key players like the PAR polarity complex and Rho family GTPases. These pathways coordinate the front–rear, apical–basal and planar polarity of endothelial cells, which are essential for the proper formation and maintenance of vascular structures. In health, endothelial polarity ensures not only the orderly development of blood vessels, with tip cells adopting distinct polarities during angiogenesis, but also ensures proper vascular integrity and function. In disease states, however, disruptions in polarity contribute to pathologies such as coronary artery disease, where altered planar polarity exacerbates atherosclerosis, and cancer, where disrupted polarity in tumor vasculature leads to abnormal vessel growth and function. Understanding cell polarity and its disruption is fundamental not only to comprehending how cells interact with their microenvironment and organize themselves into complex, organ-specific tissues but also to developing novel, targeted, and therapeutic strategies for a range of diseases, from cardiovascular disorders to malignancies, ultimately improving patient outcomes. en-copyright= kn-copyright= en-aut-name=ThihaMoe en-aut-sei=Thiha en-aut-mei=Moe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HikitaTakao en-aut-sei=Hikita en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakayamaMasanori en-aut-sei=Nakayama en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Pathophysiology and Drug Discovery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Pathophysiology and Drug Discovery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Pathophysiology and Drug Discovery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=blood vessel kn-keyword=blood vessel en-keyword=endothelial cell kn-keyword=endothelial cell en-keyword=cell polarity kn-keyword=cell polarity en-keyword=atherosclerosis kn-keyword=atherosclerosis en-keyword=cancer kn-keyword=cancer END start-ver=1.4 cd-journal=joma no-vol=E108-B cd-vols= no-issue=1 article-no= start-page=1 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Overloaded MIMO Spatial Multiplexing Independent of Antenna Setups en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper proposes overloaded MIMO spatial multiplexing that can increase the number of spatially multiplexed signal streams despite of the number of antennas on a terminal and that on a receiver. We propose extension of the channel matrix for the spatial multiplexing to achieve the superb multiplexing performance. Precoding based on the extended channel matrix plays a crucial role in carrying out such spatial multiplexing. We consider three types of QR-decomposition techniques for the proposed spatial multiplexing to improve the transmission performance. The transmission performance of the proposed spatial multiplexing is evaluated by computer simulation. The simulation reveals that the proposed overloaded MIMO spatial multiplexing can implement 6 stream-spatial multiplexing in a 2×2 MIMO system, i.e., the overloading ratio of 3.0. The superior transmission performance is achieved by the proposed overloaded MIMO spatial multiplexing with one of the QR-decomposition techniques. en-copyright= kn-copyright= en-aut-name=DennoSatoshi en-aut-sei=Denno en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SugimotoTakumi en-aut-sei=Sugimoto en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatobaKoki en-aut-sei=Matoba en-aut-mei=Koki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HouYafei en-aut-sei=Hou en-aut-mei=Yafei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=overloaded MIMO kn-keyword=overloaded MIMO en-keyword=spatial multiplexing kn-keyword=spatial multiplexing en-keyword=QR-decomposition kn-keyword=QR-decomposition en-keyword=precoding kn-keyword=precoding en-keyword=overloading ratio kn-keyword=overloading ratio END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=1 article-no= start-page=65 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230220 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Development of Automatic Inspection Systems for WRS2020 Plant Disaster Prevention Challenge Using Image Processing en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this article, an approach used for the inspection tasks in the WRS2020 Plant Disaster Prevention Challenge is explained. The tasks were categorized into three categories: reading pressure gauges, inspecting rust on a tank, and inspecting cracks in a tank. For reading pressure gauges, the “you only look once” algorithm was used to focus on a specific pressure gauge and check the pressure gauge range strings on the gauge using optical character recognition algorithm. Finally, a previously learned classifier was used to read the values shown in the gauge. For rust inspection, image processes were used to focus on a target plate that may be rusted for rust detection. In particular, it was necessary to report the rust area and distribution type. Thus, the pixel ratio and grouping of rust were used to count the rust. The approach for crack inspection was similar to that for rust. The target plate was focused on first, and then the length of the crack was measured using image processing. Its width was not measured but was calculated using the crack area and length. For each system developed to approach each task, the results of the preliminary experiment and those of WRS2020 are shown. Finally, the approaches are summarized, and planned future work is discussed. en-copyright= kn-copyright= en-aut-name=ShimizuYuya en-aut-sei=Shimizu en-aut-mei=Yuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KamegawaTetsushi en-aut-sei=Kamegawa en-aut-mei=Tetsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WangYongdong en-aut-sei=Wang en-aut-mei=Yongdong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TamuraHajime en-aut-sei=Tamura en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TeshimaTaiga en-aut-sei=Teshima en-aut-mei=Taiga kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakanoSota en-aut-sei=Nakano en-aut-mei=Sota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TadaYuki en-aut-sei=Tada en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakanoDaiki en-aut-sei=Nakano en-aut-mei=Daiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SasakiYuichi en-aut-sei=Sasaki en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=SekitoTaiga en-aut-sei=Sekito en-aut-mei=Taiga kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=UtsumiKeisuke en-aut-sei=Utsumi en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NagaoRai en-aut-sei=Nagao en-aut-mei=Rai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=SembaMizuki en-aut-sei=Semba en-aut-mei=Mizuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Okayama University kn-affil= affil-num=2 en-affil=Okayama University kn-affil= affil-num=3 en-affil=Okayama University kn-affil= affil-num=4 en-affil=Okayama University kn-affil= affil-num=5 en-affil=Okayama University kn-affil= affil-num=6 en-affil=Okayama University kn-affil= affil-num=7 en-affil=Okayama University kn-affil= affil-num=8 en-affil=Okayama University kn-affil= affil-num=9 en-affil=Okayama University kn-affil= affil-num=10 en-affil=Okayama University kn-affil= affil-num=11 en-affil=Okayama University kn-affil= affil-num=12 en-affil=Okayama University kn-affil= affil-num=13 en-affil=Okayama University kn-affil= en-keyword=WRS2020 kn-keyword=WRS2020 en-keyword=image processing kn-keyword=image processing en-keyword=auto inspection kn-keyword=auto inspection en-keyword=YOLO kn-keyword=YOLO en-keyword=OCR kn-keyword=OCR END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=6 article-no= start-page=475 end-page=483 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=C-arm Free Unilateral Biportal Endoscopic Discectomy: A Technical Note en-subtitle= kn-subtitle= en-abstract= kn-abstract=This report presents a new unilateral biportal endoscopic (UBE) technique for lumbar disc herniation without C-arm guidance. Lumbar disc herniation requires surgical intervention when conservative methods fail. Shifts towards minimally invasive percutaneous endoscopic lumbar discectomy, including uniportal and biportal approaches, have been hindered by challenges such as steep learning curves and reliance on radiation-intensive C-arm guidance. We here describe the use of standard intraoperative navigation in UBE to reduce radiation exposure and increase surgical accuracy. A 24-year-old man with low back and bilateral leg pain with gait disturbance was referred to our hospital. He had had conservative treatment for 12 months in another hospital before admission, but this proved unsuccessful. On admission he had low back pain (VAS 4/10) and bilateral leg pain (VAS 8/10), muscle weakness of the bilateral legs (manual muscle testing (MMT) grade of the extensor hallucis longus: 4/4), and numbness of the bilateral lower legs. Preoperative lumbar MRI showed L4/5 large central disc herniation. He underwent C-arm free UBE discectomy under the guidance of O-arm navigation. The surgery was successful, with postoperative lumbar MRI showing good decompression of the dural sac and bilateral L5 nerve roots. The MMT grade and sensory function of both legs had recovered fully on final follow-up at one year. The new UBE technique under navigation guidance was shown to be useful for lumbar disc herniation. This innovative technique was safe and accurate for the treatment of lumbar intervertebral disc herniation, and minimized radiation exposure to surgeons. en-copyright= kn-copyright= en-aut-name=XiangHongfei en-aut-sei=Xiang en-aut-mei=Hongfei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=LatkaKajetan en-aut-sei=Latka en-aut-mei=Kajetan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MastePraful en-aut-sei=Maste en-aut-mei=Praful kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaMasato en-aut-sei=Tanaka en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KumawatChetan en-aut-sei=Kumawat en-aut-mei=Chetan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AratakiShinya en-aut-sei=Arataki en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FujiwaraYoshihiro en-aut-sei=Fujiwara en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TaokaTakuya en-aut-sei=Taoka en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MiyamotoAkiyoshi en-aut-sei=Miyamoto en-aut-mei=Akiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= affil-num=2 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= affil-num=3 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= affil-num=4 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= affil-num=5 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= affil-num=6 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= affil-num=7 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= affil-num=8 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= affil-num=9 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= en-keyword=lumbar disc herniation kn-keyword=lumbar disc herniation en-keyword=unilateral biportal endoscopic technique kn-keyword=unilateral biportal endoscopic technique en-keyword=navigation kn-keyword=navigation en-keyword=O-arm kn-keyword=O-arm en-keyword=minimally invasive spine surgery (MISS) kn-keyword=minimally invasive spine surgery (MISS) END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=6 article-no= start-page=429 end-page=437 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Partial versus Radical Nephrectomy for Small Renal Cancer: Comparative Propensity Score-Matching Analysis of Cardiovascular Event Risk en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although partial nephrectomy (PN) is preferred over radical nephrectomy (RN) for preserving renal function in patients with cT1 renal cancer, its impact on cardiovascular events (CVe) remains controversial. This study aimed to compare PN and RN in regard to the occurrence of CVe, including cerebrovascular events and exacerbation of hypertension (HT). We retrospectively analyzed 418 consecutive patients who underwent PN or RN for cT1 renal cancer. Propensity score-matching analysis was used to adjust for imbalances between patients who underwent PN and RN, leaving 102 patients in each group. The 5-year probability of cumulative CVe incidence was 6% in the PN group and 12% in the RN group (p=0.03), with a median follow-up of 73.5 months. The statistical significance was retained after propensity score matching for patients without preoperative proteinuria (p=0.03). For all CVe including cerebrovascular events and exacerbation of HT analyzed, PN provided a lower probability of occurrence than RN in patients with small renal cancers. en-copyright= kn-copyright= en-aut-name=KubotaRisa en-aut-sei=Kubota en-aut-mei=Risa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=BekkuKensuke en-aut-sei=Bekku en-aut-mei=Kensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KatayamaSatoshi en-aut-sei=Katayama en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IwataTakehiro en-aut-sei=Iwata en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NishimuraShingo en-aut-sei=Nishimura en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=EdamuraKohei en-aut-sei=Edamura en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KobayashiTomoko en-aut-sei=Kobayashi en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KobayashiYasuyuki en-aut-sei=Kobayashi en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=chronic kidney disease kn-keyword=chronic kidney disease en-keyword=hypertension kn-keyword=hypertension en-keyword=nephrectomy kn-keyword=nephrectomy en-keyword=proteinuria kn-keyword=proteinuria END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=5 article-no= start-page=434 end-page=448 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230905 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of Vibration Behavior in Low-Frequency Vibration Cutting on Surface Properties of Workpiece en-subtitle= kn-subtitle= en-abstract= kn-abstract=　The objective of this study was to determine the effect of vibration behavior on workpiece surface properties in low-frequency vibration cutting. The effects of the parameters that determine vibration behavior on surface roughness were quantitatively evaluated through a comparison with other cutting conditions. Furthermore, by clarifying how the surface properties of the workpiece, such as roughness, roundness, and cross-sectional curves, change depending on the vibration behavior, a search for optimal conditions for low-frequency vibration cutting was conducted. The best surface properties were obtained under the condition of spindle rotation per vibration E=4.5. By using a value close to the minimum possible spindle rotation R=0.5 when the workpiece is retracted, it is expected to be effective in suppressing the variation in surface roughness at each phase angle; this variation is characteristic of low-frequency vibration cutting. Workpieces machined under low-frequency vibration conditions such as (E=2.5, R=1.0) and (E=3.5, R=1.0) were found to form characteristic surface patterns on the workpiece surface owing to a phenomenon in which the depth of the cut to the workpiece changes. en-copyright= kn-copyright= en-aut-name=KodamaHiroyuki en-aut-sei=Kodama en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsunoShota en-aut-sei=Matsuno en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShibataNaoyuki en-aut-sei=Shibata en-aut-mei=Naoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhashiKazuhito en-aut-sei=Ohashi en-aut-mei=Kazuhito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Okayama University kn-affil= affil-num=2 en-affil=Okayama University kn-affil= affil-num=3 en-affil=Okayama University kn-affil= affil-num=4 en-affil=Okayama University kn-affil= en-keyword=low-frequency vibration cutting kn-keyword=low-frequency vibration cutting en-keyword=vibration behavior kn-keyword=vibration behavior en-keyword=surface roughness kn-keyword=surface roughness en-keyword=cross-sectional curve kn-keyword=cross-sectional curve END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue= article-no= start-page=78366 end-page=78378 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=2024 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Aromug: A Mug-Type Olfactory Interface to Enhance the Sweetness Perception of Beverages en-subtitle= kn-subtitle= en-abstract= kn-abstract=Sugary beverages are a significant contributor to sugar consumption, and their excessive consumption is associated with increased risks of elevated blood glucose levels and diabetes. Many individuals have a strong preference for sugary beverages and often find beverages with lower sugar content to be less satisfying. Attempts to switch to less sugary options are frequently short-lived, leading to a return to higher-sugar beverages. Recognizing that 75 – 95% of taste perception is influenced by scent, we investigated a scent-based approach to reduce sugar intake while preserving the perception of sweetness. This study introduces an olfactory interface in the form of a mug named “Aromug,” designed to emit a sweet scent in sync with the drinking action. Aromug incorporates motion sensing and scent presentation functions to enhance the perceived sweetness of a beverage, thereby encouraging a gradual reduction in sugar intake. Our experiments, involving 33 participants, demonstrated that the combined scents of sugar-free coffee and chocolate increased the perception of sweetness (p =1.641×10−2 ). The study also found that the simultaneous presentation of scent and visual cues improved taste satisfaction and sweetness perception. Additionally, we observed variations in sweetness preference related to age and frequency of coffee consumption. It was particularly observed that people in their 20s and those who frequently drink coffee tend to perceive the taste of beverages as sweeter. This suggests a potential for Aromug to customize the scent experience based on individual preferences, offering a novel way to encourage healthier beverage choices. en-copyright= kn-copyright= en-aut-name=MayumiDaiki en-aut-sei=Mayumi en-aut-mei=Daiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakamuraYugo en-aut-sei=Nakamura en-aut-mei=Yugo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsudaYuki en-aut-sei=Matsuda en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MisakiShinya en-aut-sei=Misaki en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YasumotoKeiichi en-aut-sei=Yasumoto en-aut-mei=Keiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Science and Technology, Nara Institute of Science and Technology kn-affil= affil-num=2 en-affil=Faculty of Information Science and Electrical Engineering, Kyushu University kn-affil= affil-num=3 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Science and Technology, Nara Institute of Science and Technology kn-affil= affil-num=5 en-affil=Graduate School of Science and Technology, Nara Institute of Science and Technology kn-affil= en-keyword=Olfaction kn-keyword=Olfaction en-keyword=olfactory interfaces kn-keyword=olfactory interfaces en-keyword=olfactory display kn-keyword=olfactory display en-keyword=scents kn-keyword=scents en-keyword=taste evaluation kn-keyword=taste evaluation en-keyword=smell kn-keyword=smell en-keyword=olfactory perception kn-keyword=olfactory perception en-keyword=behavior change support kn-keyword=behavior change support END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue= article-no= start-page=146551 end-page=146559 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Protection Scheme With Speech Processing Against Audio Adversarial Examples en-subtitle= kn-subtitle= en-abstract= kn-abstract=Machine learning technologies have improved the accuracy of speech recognition systems, and devices using those systems, such as smart speakers and AI assistants, are now in wide use. However, speech recognition systems have security vulnerabilities. In particular, a known machine learning vulnerability called audio adversarial examples (AAEs), which causes misrecognition in speech recognition systems, has become a problem. We propose a scheme for using speech processing to protect speech recognition systems from AAEs, preventing misrecognitions by slight processing of input speech that does not affect the recognition of normal speech. We use two kinds of processing: speed and frequency. Evaluation results show that the proposed scheme can reduce the success rate of attack speech to about 1% while maintaining about 85% recognition rates for normal speech. en-copyright= kn-copyright= en-aut-name=TarutaniYuya en-aut-sei=Tarutani en-aut-mei=Yuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamamotoTaisei en-aut-sei=Yamamoto en-aut-mei=Taisei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FukushimaYukinobu en-aut-sei=Fukushima en-aut-mei=Yukinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YokohiraTokumi en-aut-sei=Yokohira en-aut-mei=Tokumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= en-keyword=Speech recognition system kn-keyword=Speech recognition system en-keyword=security kn-keyword=security en-keyword=audio adversarial example kn-keyword=audio adversarial example END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue= article-no= start-page=142592 end-page=142605 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20241001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=MUSIC Spectrum Based Interference Detection, Localization, and Interference Arrival Prediction for mmWave IRS-MIMO System en-subtitle= kn-subtitle= en-abstract= kn-abstract=For a millimeter wave (mmWave) intelligent re-configurable surface (IRS)-MIMO system, if it can correctly detect the interference occurrence and their locations, the patterns of interference signal can be collected and learned using machine learning for the prediction of interference arrival. With the information of interference location and activity pattern, the capacity of the system can be largely improved using many techniques such as beamforming, interference cancellation, and transmission scheduling. This paper aims to detect interference occurrence using a low-complexity MUSIC (MUSIC: multiple signal classification) spectrum-based method, and then localize their sources for mmWave IRS-MIMO system. The MUSIC spectrum of wireless system can be regarded as somehow the 'signature' related to the signals transmitted from different users or interference. We utilize such property to detect the occurrence of interference, and then localize their sources in a low-complexity way. Finally, the pattern of interference occurrence can be learned to predict the interference arrival from the collected data. This paper also proposed an efficient probabilistic neural network (PNN)-based predictor for the interference arrival prediction and showed its prediction accuracy. From simulated results, our proposed method can achieve the correct results with the accuracy near to 100% when the fingerprint samples is over 10. In addition, the localization error can be within 1 m with more than 65% and 43% for Y-axis and X-axis, respectively. Finally, based on the results of the interference occurrence, the proposed PNN-based predictor for the interference arrival prediction can capture correctly the similar distribution function of the coming continuous idle status. en-copyright= kn-copyright= en-aut-name=HouYafei en-aut-sei=Hou en-aut-mei=Yafei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YanoKazuto en-aut-sei=Yano en-aut-mei=Kazuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SugaNorisato en-aut-sei=Suga en-aut-mei=Norisato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WebberJulian en-aut-sei=Webber en-aut-mei=Julian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=DennoSatoshi en-aut-sei=Denno en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SakanoToshikazu en-aut-sei=Sakano en-aut-mei=Toshikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Wave Engineering Laboratories, Advanced Telecommunications Research Institute International kn-affil= affil-num=3 en-affil=Wave Engineering Laboratories, Advanced Telecommunications Research Institute International kn-affil= affil-num=4 en-affil=Wave Engineering Laboratories, Advanced Telecommunications Research Institute International kn-affil= affil-num=5 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=Wave Engineering Laboratories, Advanced Telecommunications Research Institute International kn-affil= en-keyword=Interference detection kn-keyword=Interference detection en-keyword=MUSIC spectrum kn-keyword=MUSIC spectrum en-keyword=interference localization kn-keyword=interference localization en-keyword=prediction of interference arrival kn-keyword=prediction of interference arrival en-keyword=probabilistic neural network kn-keyword=probabilistic neural network END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=5 article-no= start-page=357 end-page=362 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Factors Affecting Dynamic Postural Control Ability in Adolescent Idiopathic Scoliosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Research on postural control in patients with adolescent idiopathic scoliosis (AIS) has focused on static postural control, with few studies assessing dynamic postural control. We aimed to identify factors affecting index of postural stability (IPS), a dynamic postural control parameter, in patients with AIS. The participants comprised 50 female patients with AIS. We measured the IPS using stabilometry to evaluate dynamic postural control ability. We investigated age of the participants, major curve position (thoracic or thoracolumbar/lumbar), Cobb angle, and coronal balance. We then assessed the relationships between stabilometry parameters and other variables. IPS was analyzed with a linear regression model. Coronal balance, major curve position, and age each correlated with dynamic postural control ability. The Cobb angle showed no correlation with any of the parameters. Our results offer new insights into the assessment of postural control in patients with AIS. en-copyright= kn-copyright= en-aut-name=YamawakiRyoko en-aut-sei=Yamawaki en-aut-mei=Ryoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OdaYoshiaki en-aut-sei=Oda en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamaneShuhei en-aut-sei=Yamane en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UotaniKoji en-aut-sei=Uotani en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MisawaHaruo en-aut-sei=Misawa en-aut-mei=Haruo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KatayamaYoshimi en-aut-sei=Katayama en-aut-mei=Yoshimi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HamadaMasanori en-aut-sei=Hamada en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Division of Physical Medicine and Rehabilitation, Okayama University kn-affil= affil-num=2 en-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Division of Physical Medicine and Rehabilitation, Okayama University kn-affil= affil-num=4 en-affil=Department of Orthopaedic Surgery, Okayama University kn-affil= affil-num=5 en-affil=Ryusoh Orthopaedic Hospital kn-affil= affil-num=6 en-affil=Division of Physical Medicine and Rehabilitation, Okayama University kn-affil= affil-num=7 en-affil=Division of Physical Medicine and Rehabilitation, Okayama University kn-affil= affil-num=8 en-affil=Division of Physical Medicine and Rehabilitation, Okayama University kn-affil= en-keyword=adolescent idiopathic scoliosis kn-keyword=adolescent idiopathic scoliosis en-keyword=postural control kn-keyword=postural control en-keyword=coronal balance kn-keyword=coronal balance en-keyword=index of postural stability kn-keyword=index of postural stability en-keyword=stabilometry kn-keyword=stabilometry END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue= article-no= start-page=111371 end-page=111385 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Adaptive Resonance Theory-Based Global Topological Map Building for an Autonomous Mobile Robot en-subtitle= kn-subtitle= en-abstract= kn-abstract=3D space perception is one of the key technologies for autonomous mobile robots that perform tasks in unknown environments. Among these, building global topological maps for autonomous mobile robots is a challenging task. In this study, we propose a method for learning topological structures from unknown data distributions based on competitive learning, a type of unsupervised learning. For this purpose, adaptive resonance theory-based Topological Clustering (ATC), which can avoid catastrophic forgetting of previously measured point clouds, is applied as a learning method. Furthermore, by extending ATC with Different Topologies (ATC-DT) with multiple topological structures for extracting the traversable information of terrain environments, a path planning method is realized that can reach target points set in an unknown environment. Path planning experiments in unknown environments show that, compared to other methods, ATC-DT can build a global topology map with high accuracy and stability using only measured 3D point cloud and robot position information. en-copyright= kn-copyright= en-aut-name=TodaYuichiro en-aut-sei=Toda en-aut-mei=Yuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MasuyamaNaoki en-aut-sei=Masuyama en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Informatics, Osaka Metropolitan University kn-affil= en-keyword=Adaptive resonance theory kn-keyword=Adaptive resonance theory en-keyword=autonomous mobile robot kn-keyword=autonomous mobile robot en-keyword=topological map kn-keyword=topological map END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue= article-no= start-page=98175 end-page=98188 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=2024 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Feasibility of Active Reactance Compensator for Autonomously Maximizing Repeater Coil Current of Wireless Power Transfer System Against Variations in Resonant Frequency and Magnetic Coupling Intensity en-subtitle= kn-subtitle= en-abstract= kn-abstract=In resonant inductive coupling wireless power transfer systems, a repeater resonator is crucial in expanding the charging area, enabling efficient power supply to receivers, such as small Internet of Things (IoT) devices sparsely distributed in a wide area. However, the repeater current is highly susceptible to deviations in resonance frequency due to manufacturing tolerance and aging, as well as to the magnetic coupling between the transmitter and repeater coils, potentially leading to insufficient amplitude. Consequently, the magnetic field generated by the repeater decreases and the receiver may be difficult to obtain sufficient power from the transmitter via the repeater. To address this problem, this paper proposes a wireless power transfer system with active reactance compensators incorporated in the repeater and the transmitter. The proposed system can equivalently adjust the resonant frequencies of the transmitter and repeater to stably maximize the repeater coil current regardless of the variations in the resonant frequency and the magnetic coupling intensity. Experiments successfully verify that the proposed system can provide a more stable and larger repeater current and output power than the conventional system against the variations in the magnetic field intensity and the resonant frequency of the repeater, validating the feasibility of the proposed system for practical utilization of the repeater in expanding the charging area. en-copyright= kn-copyright= en-aut-name=IshiharaMasataka en-aut-sei=Ishihara en-aut-mei=Masataka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UmetaniKazuhiro en-aut-sei=Umetani en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KonishiAkihiro en-aut-sei=Konishi en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HirakiEiji en-aut-sei=Hiraki en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Faculty of Life, Environment, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Life, Environment, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Science and Engineering, Chiba University kn-affil= affil-num=4 en-affil=Faculty of Life, Environment, Natural Science and Technology, Okayama University kn-affil= en-keyword=Resonant inductive coupling kn-keyword=Resonant inductive coupling en-keyword=wireless power transfer kn-keyword=wireless power transfer en-keyword=repeater kn-keyword=repeater en-keyword=intermediate resonator kn-keyword=intermediate resonator en-keyword=frequency splitting phenomenon kn-keyword=frequency splitting phenomenon END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=3 article-no= start-page=3934 end-page=3949 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Designing and Prototyping an Axial-Flux Machine Using Ferrite PM and Round Wire for Traction Applications: Comparison With a Radial-Flux Machine Using Nd-Fe-B PM and Rectangular Wire en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper proposes a novel axial-flux permanent magnet machine (AFPM) employing ferrite permanent magnets (PMs) and round copper wire. The proposed AFPM adopts a novel rotor structure and uses tooth-tips with a suitable trapezoidal shape. These structures compensate for the low magnetomotive force of the round copper wire and ferrite PMs, achieving high performance at low cost. Additionally, compared with an off-the-shelf radial-flux permanent magnet machine (RFPM) using Nd-sintered PMs and rectangular copper wire, the proposed AFPM achieves the same output power and higher efficiency, despite using ferrite PMs and the round copper wire. Finally, a prototype of the proposed AFPM was manufactured and evaluated experimentally. The prototype achieved a high efficiency of over 95% across a wide operating area while maintaining required maximum torque, suggesting its potential for traction applications. en-copyright= kn-copyright= en-aut-name=TsunataRen en-aut-sei=Tsunata en-aut-mei=Ren kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IzumiyaKosuke en-aut-sei=Izumiya en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakemotoMasatsugu en-aut-sei=Takemoto en-aut-mei=Masatsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ImaiJun en-aut-sei=Imai en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SaitoTatsuya en-aut-sei=Saito en-aut-mei=Tatsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UenoTomoyuki en-aut-sei=Ueno en-aut-mei=Tomoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Division of Industrial Innovation Sciences Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Industrial Innovation Sciences Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Industrial Innovation Sciences Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Division of Industrial Innovation Sciences Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Sumitomo Electric Industries Ltd. kn-affil= affil-num=6 en-affil=Sumitomo Electric Industries Ltd. kn-affil= en-keyword=Axial gap motor kn-keyword=Axial gap motor en-keyword=axial-flux machine kn-keyword=axial-flux machine en-keyword=carbon fiber rotor kn-keyword=carbon fiber rotor en-keyword=carbon fiber-reinforced plastic kn-keyword=carbon fiber-reinforced plastic en-keyword=city commuter kn-keyword=city commuter en-keyword=ferrite magnet kn-keyword=ferrite magnet en-keyword=flat copper wire kn-keyword=flat copper wire en-keyword=high circumferential speed kn-keyword=high circumferential speed en-keyword=radial-flux machine kn-keyword=radial-flux machine END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=3 article-no= start-page=215 end-page=225 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202406 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Assessment of a New Elbow Joint Positioning Method Using Area Detector Computed Tomography en-subtitle= kn-subtitle= en-abstract= kn-abstract=We propose a sitting position that achieves both high image quality and a reduced radiation dose in elbow joint imaging by area detector computed tomography (ADCT), and we compared it with the ‘superman’ and supine positions. The volumetric CT dose index (CTDIvol) for the sitting, superman, and supine positions were 2.7, 8.0, and 20.0 mGy and the dose length products (DLPs) were 43.4, 204.7, and 584.8 mGy • cm, respectively. In the task-based transfer function (TTF), the highest value was obtained for the sitting position in both bone and soft tissue images. The noise power spectrum (NPS) of bone images showed that the superman position had the lowest value up to approx. 1.1 cycles/mm or lower, whereas the sitting position had the lowest value when the NPS was greater than approx. 1.1 cycles/mm. The overall image quality in an observer study resulted in the following median Likert scores for Readers 1 and 2: 5.0 and 5.0 for the sitting position, 4.0 and 3.5 for the superman position, and 4.0 and 2.0 for the supine position. These results indicate that our proposed sitting position with ADCT of the elbow joint can provide superior image quality and allow lower radiation doses compared to the superman and supine positions. en-copyright= kn-copyright= en-aut-name=AkagawaTakuya en-aut-sei=Akagawa en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukuiRyohei en-aut-sei=Fukui en-aut-mei=Ryohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KidaKatsuhiro en-aut-sei=Kida en-aut-mei=Katsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsuuraRyutaro en-aut-sei=Matsuura en-aut-mei=Ryutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShimadaMakoto en-aut-sei=Shimada en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KinoshitaMitsuhiro en-aut-sei=Kinoshita en-aut-mei=Mitsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AkagawaYoko en-aut-sei=Akagawa en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=GotoSachiko en-aut-sei=Goto en-aut-mei=Sachiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Radiological Technology, Tokushima Red Cross Hospital kn-affil= affil-num=2 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Radiology, Osaka International Cancer Institute kn-affil= affil-num=6 en-affil=Department of Radiology, Tokushima Red Cross Hospital kn-affil= affil-num=7 en-affil=Department of Radiology, Tokushima Red Cross Hospital kn-affil= affil-num=8 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= en-keyword=area detector computed tomography kn-keyword=area detector computed tomography en-keyword=elbow joint kn-keyword=elbow joint en-keyword=sitting position kn-keyword=sitting position en-keyword=dose reduction kn-keyword=dose reduction en-keyword=image quality assessment kn-keyword=image quality assessment END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=2 article-no= start-page=163 end-page=170 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Impact of Light Touch and Pin Prick on Functional Outcomes in Patients with Traumatic Spinal Cord Injury en-subtitle= kn-subtitle= en-abstract= kn-abstract=A spinal cord injury (SCI) can cause severe lifelong functional disability and profoundly affect an individual’s daily life. We investigated the prediction of patients’ post-SCI functional outcomes by evaluating sensory scores rather than motor scores, as the latter’s association with functional outcomes is well established. We examined patients’ responses to a light touch (LT) and pin prick (PP) at admission and the response data’s usefulness as predictors of functional outcomes (i.e., ability to perform activities of daily living) at discharge. This exploratory observational study used data from the Japanese National Spinal Cord Injury Database (SCI-J). Data from 3,676 patients who met the inclusion criteria and were admitted for an SCI between 1997 and 2020 were analyzed. The motor score of the Functional Independence Measure (mFIM) at discharge was used as an index of functional outcome. A multiple regression analysis revealed that the mFIM was associated with both the LT response (β=0.07 (0.01), p<0.001) and the PP response (β=0.07 (0.01), p<0.001) at admission. The false discovery rate log-worth values for LT and PP were 6.6 and 8.5, respectively. Our findings demonstrate that LT and PP scores at admission can help predict patients’ functional outcomes after an SCI, although the magnitude of their contributions is not high. en-copyright= kn-copyright= en-aut-name=DeguchiTakayuki en-aut-sei=Deguchi en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KandaKanae en-aut-sei=Kanda en-aut-mei=Kanae kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FurusawaKazunari en-aut-sei=Furusawa en-aut-mei=Kazunari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=Nlandu Roger Ngatu en-aut-sei=Nlandu Roger Ngatu en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HiraoTomohiro en-aut-sei=Hirao en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Rehabilitation, Kagawa Rosai Hospital kn-affil= affil-num=2 en-affil=Department of Public Health, Faculty of Medicine, Kagawa University kn-affil= affil-num=3 en-affil=Department of Rehabilitation Medicine, Kibikogen Rehabilitation Center for Employment Injuries kn-affil= affil-num=4 en-affil=Department of Public Health, Faculty of Medicine, Kagawa University kn-affil= affil-num=5 en-affil=Department of Public Health, Faculty of Medicine, Kagawa University kn-affil= en-keyword=functional independence measure kn-keyword=functional independence measure en-keyword=light touch kn-keyword=light touch en-keyword=pin prick kn-keyword=pin prick en-keyword=spinal cord injury kn-keyword=spinal cord injury en-keyword=Japanese National Spinal Cord Injury Database kn-keyword=Japanese National Spinal Cord Injury Database END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=2 article-no= start-page=95 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Roles of Neuropeptide Y in Respiratory Disease Pathogenesis via the Airway Immune Response en-subtitle= kn-subtitle= en-abstract= kn-abstract=The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases. en-copyright= kn-copyright= en-aut-name=ItanoJunko en-aut-sei=Itano en-aut-mei=Junko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyaharaNobuaki en-aut-sei=Miyahara en-aut-mei=Nobuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital kn-affil= en-keyword=neuropeptide y kn-keyword=neuropeptide y en-keyword=Y1 receptor kn-keyword=Y1 receptor en-keyword=airway immune response kn-keyword=airway immune response en-keyword=bronchial epithelial cells kn-keyword=bronchial epithelial cells en-keyword=respiratory disease kn-keyword=respiratory disease END start-ver=1.4 cd-journal=joma no-vol=E107-B cd-vols= no-issue=3 article-no= start-page=339 end-page=348 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Low Complexity Overloaded MIMO Non-Linear Detector with Iterative LLR Estimation en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper proposes a non-linear overloaded MIMO detector that outperforms the conventional soft-input maximum likelihood detector (MLD) with less computational complexity. We propose iterative log-likelihood ratio (LLR) estimation and multi stage LLR estimation for the proposed detector to achieve such superior performance. While the iterative LLR estimation achieves better BER performance, the multi stage LLR estimation makes the detector less complex than the conventional soft-input maximum likelihood detector (MLD). The computer simulation reveals that the proposed detector achieves about 0.6 dB better BER performance than the soft-input MLD with about half of the soft-input MLD's complexity in a 6 × 3 overloaded MIMO OFDM system. en-copyright= kn-copyright= en-aut-name=DennoSatoshi en-aut-sei=Denno en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MakabeShuhei en-aut-sei=Makabe en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HouYafei en-aut-sei=Hou en-aut-mei=Yafei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=overloaded MIMO kn-keyword=overloaded MIMO en-keyword=non-linear detector kn-keyword=non-linear detector en-keyword=soft-input decoding kn-keyword=soft-input decoding en-keyword=noise cancellation kn-keyword=noise cancellation en-keyword=ordering kn-keyword=ordering en-keyword=complexity reduction kn-keyword=complexity reduction END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue= article-no= start-page=28201 end-page=28211 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=WLAN Channel Status Duration Prediction for Audio and Video Services Using Probabilistic Neural Networks en-subtitle= kn-subtitle= en-abstract= kn-abstract=Due to massive increase in wireless access from smartphones, IoT devices, WLAN is aiming to improve its spectrum efficiency (SE) using many technologies. Some interesting techniques for WLAN systems are flexible allocation of frequency resource and cognitive radio (CR) techniques which expect to find more useful spectrum resource by modeling and then predicting of channel status using the captured statistics information of the used spectrum. This paper investigates the prediction accuracy of busy/idle duration of two major wireless services: audio service and video service using neural network based predictor. We first study the statistics distribution of their time-series busy/idle (B/I) duration, and then analyze the predictability of the busy/idle duration based on the predictability theory. Then, we propose a data categorization (DC) method which categorizes the duration of recent B/I duration according the their ranges to make the duration of next data be distributed into several streams. From the predictability analysis of each stream and the prediction performance using the probabilistic neural network (PNN), it can be confirmed that the proposed DC can improve the prediction accuracy of time-series data in partial streams. en-copyright= kn-copyright= en-aut-name=HouYafei en-aut-sei=Hou en-aut-mei=Yafei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DennoSatoshi en-aut-sei=Denno en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Wireless LAN kn-keyword=Wireless LAN en-keyword=Wireless communication kn-keyword=Wireless communication en-keyword=Media streaming kn-keyword=Media streaming en-keyword=Wireless sensor networks kn-keyword=Wireless sensor networks en-keyword=Resource management kn-keyword=Resource management en-keyword=Probability distribution kn-keyword=Probability distribution en-keyword=Channel allocation kn-keyword=Channel allocation en-keyword=Audio-visual systems kn-keyword=Audio-visual systems en-keyword=Data processing kn-keyword=Data processing en-keyword=Predictive models kn-keyword=Predictive models en-keyword=Neural networks kn-keyword=Neural networks en-keyword=Channel status duration prediction kn-keyword=Channel status duration prediction en-keyword=WLAN audio/video traffic kn-keyword=WLAN audio/video traffic en-keyword=data predictability analysis kn-keyword=data predictability analysis en-keyword=probabilistic neural network (PNN) kn-keyword=probabilistic neural network (PNN) END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=1 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240205 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The authorship of teachers: jissen kiroku as the core of professionalism in Japanese jugyo kenkyu en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose
This paper aims to discuss the significance of teacher authorship (jissen kiroku) developed during jugyo kenkyu. Specifically, it explores the structural conditions of jugyo kenkyu that enabled the flourishing of jissen kiroku.

Design/methodology/approach
To find how jissen kiroku developed in jugyo kenkyu, this paper settled triad of authors-text-readers as the analytical perspective. Disputes through 1960s–1980s are adequate to inquire because it can elucidate how readers read jissen kiroku, which is typically challenging to observe.

Findings
Jissen kiroku is a powerful tool for semantically preserving, reconstructing and consolidating professional values and knowledge in jugyo kenkyu with deepening connoisseurship. Voluntary educational research associations (VERAs) encourage teachers to write and read jissen kiroku to develop their professionalism, which also helped develop exclusive semantics within the field. These developments were possible due to the public nature of jissen kiroku, disseminated to lesson study (LS) actors, thereby strengthening discussions both inside and outside VERAs.

Research limitations/implications
The paper proposes shift in views on educational science and emphasizes authorship as authority in that professionalism of teaching can be protected and elevated through authoring.

Originality/value
The significant roles of writing practice have not been explored enough. This paper finds the value of authorship in terms of public nature and openness to all teachers which enable the enhancement of professionalism of the LS field. en-copyright= kn-copyright= en-aut-name=MiyamotoYuichi en-aut-sei=Miyamoto en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Education, Okayama University kn-affil= en-keyword=Jugyo kenkyu kn-keyword=Jugyo kenkyu en-keyword=Jissen kiroku kn-keyword=Jissen kiroku en-keyword=Authorship kn-keyword=Authorship en-keyword=Voluntary educational research associations kn-keyword=Voluntary educational research associations en-keyword=Semantic preservation and reconstruction kn-keyword=Semantic preservation and reconstruction en-keyword=Connoisseurship kn-keyword=Connoisseurship END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue= article-no= start-page=109435 end-page=109447 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Proposal of an Axial-Flux Permanent-Magnet Machine Employing SMC Core With Tooth-Tips Constructed by One-Pressing Process: Improving Torque and Manufacturability en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study aims to improve the torque performance and manufacturability of axial-flux permanent magnet (AFPM) machines. Hence, we propose a novel AFPM machine that employs a soft magnetic composite (SMC) core with tooth-tips constructed by a one-pressing process and die. In this paper, the proposed AFPM machine is compared to two conventional AFPM machines using an SMC core. One of them has open-slot structure without tooth-tips. Another model employs an SMC core with tooth-tips pressed by a conventional pressing process that requires multiple operations and dies. As a result of the comparison, the proposed AFPM machine realizes a much higher torque than the two conventional machines. Additionally, the manufacturability of an SMC core with tooth-tips pressed by the proposed method is superior to the conventional one because the proposed structure can be realized by the one-pressing process and die. Furthermore, two prototypes of the proposed AFPM machine and the conventional one with an open-slot structure are fabricated, and then, they are compared by experiments. Consequently, the proposed AFPM machine achieves a 15.7% higher torque than that of the conventional machine using an open-slot structure. Finally, this paper presents an improved design of an AFPM machine with SMC cores using the proposed pressing process. As a result, the proposed AFPM realizes a 20% larger torque than that of a conventional model employing an open-slot structure. en-copyright= kn-copyright= en-aut-name=TsunataRen en-aut-sei=Tsunata en-aut-mei=Ren kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakemotoMasatsugu en-aut-sei=Takemoto en-aut-mei=Masatsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ImaiJun en-aut-sei=Imai en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SaitoTatsuya en-aut-sei=Saito en-aut-mei=Tatsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=UenoTomoyuki en-aut-sei=Ueno en-aut-mei=Tomoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Sumitomo Electric Industries Ltd. kn-affil= affil-num=5 en-affil=Sumitomo Electric Industries Ltd. kn-affil= en-keyword=Pressing kn-keyword=Pressing en-keyword=Stator cores kn-keyword=Stator cores en-keyword=Magnetic cores kn-keyword=Magnetic cores en-keyword=Torque kn-keyword=Torque en-keyword=Atmospheric modeling kn-keyword=Atmospheric modeling en-keyword=Presses kn-keyword=Presses en-keyword=Manufacturing kn-keyword=Manufacturing en-keyword=Mass production kn-keyword=Mass production en-keyword=Axial-flux permanent magnet machine kn-keyword=Axial-flux permanent magnet machine en-keyword=soft magnetic composite (SMC) kn-keyword=soft magnetic composite (SMC) en-keyword=PMSM kn-keyword=PMSM en-keyword=tooth-tips kn-keyword=tooth-tips en-keyword=torque kn-keyword=torque en-keyword=press process kn-keyword=press process en-keyword=semi-closed slot structure kn-keyword=semi-closed slot structure en-keyword=axial gap motor kn-keyword=axial gap motor en-keyword=mass production kn-keyword=mass production en-keyword=YASA motor kn-keyword=YASA motor en-keyword=shoe kn-keyword=shoe END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue=3 article-no= start-page=3353 end-page=3367 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230313 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comparison of Thermal Characteristics in Various Aspect Ratios for Radial-Flux and Axial-Flux Permanent Magnet Machines en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper proposes an axial-flux permanent magnet machine (AFPM) that uses a neodymium-bonded permanent magnet (Nd-bonded PM) and a coreless rotor structure and assesses how it performs in industrial applications requiring high efficiency and low cost. The AFPM is able to achieve high efficiency in high-speed regions because its Nd-bonded PM can restrain eddy current loss. Additionally, the AFPM can continuously function at the rated operating point without a cooling system, so the expenses for one can be eliminated. Hence, the AFPM can simultaneously achieve high efficiency and low-cost mass production. In this paper, a comprehensive comparison including the thermal characteristics of the proposed AFPM and a conventional radial-flux permanent magnet machine (RFPM) is shown. Furthermore, this paper also focuses on how the aspect ratio influences the thermal characteristics of both machines. Finally, the effectiveness of the proposed AFPM in industrial applications is assessed using 3D-FEA and experimental results. en-copyright= kn-copyright= en-aut-name=TsunataRen en-aut-sei=Tsunata en-aut-mei=Ren kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakemotoMasatsugu en-aut-sei=Takemoto en-aut-mei=Masatsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ImaiJun en-aut-sei=Imai en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SaitoTatsuya en-aut-sei=Saito en-aut-mei=Tatsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=UenoTomoyuki en-aut-sei=Ueno en-aut-mei=Tomoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Division of Industrial Innovation Sciences Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Industrial Innovation Sciences Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Industrial Innovation Sciences Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Sumitomo Electric Industries Ltd kn-affil= affil-num=5 en-affil=Sumitomo Electric Industries Ltd kn-affil= en-keyword=Aspect ratio kn-keyword=Aspect ratio en-keyword=axial-flux machine kn-keyword=axial-flux machine en-keyword=axial-gap motor kn-keyword=axial-gap motor en-keyword=cooling kn-keyword=cooling en-keyword=high efficiency kn-keyword=high efficiency en-keyword=mass production kn-keyword=mass production en-keyword=PMSM kn-keyword=PMSM en-keyword=radial-flux machine kn-keyword=radial-flux machine en-keyword=soft magnetic composite kn-keyword=soft magnetic composite en-keyword=thermal characteristic kn-keyword=thermal characteristic END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=1 article-no= start-page=65 end-page=72 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=COVID-19 and Spanish Flu, the Representative Pandemics of the 21st and 20th Centuries en-subtitle= kn-subtitle= en-abstract= kn-abstract=We are still in the early stage of 21st century and the two pandemics Spanish flu and COVID-19 are the presentative pandemics in 20th and 21st centuries, respectively. The Spanish flu pandemic raged from 1918 to 1920, just after World War I. It was the first influenza pandemic worldwide; since then, humankind has experienced many such pandemics. Spanish flu is caused by a virus. However, since virology was not well established at that time, the new clinical system was needed to cope with “unknown pathogen”; during the pandemic, high infection rates were recorded, but our predecessors managed to somehow tackle the situation. With respect to the ongoing COVID-19 pandemic, both the virus and its genome were clarified quickly. Nonetheless, it has turned out to be quite an intriguing infectious disease, with the high rates in developed countries, such as the US and those in Europe, which have aging societies, and low rates in developing countries such as those in Africa, where the population is largely young. Here, I compared and discuss the two pandemics, COVID-19 and Spanish flu. en-copyright= kn-copyright= en-aut-name=ShinodaSumio en-aut-sei=Shinoda en-aut-mei=Sumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Collaborative Research Center for Infectious Diseases in India, Okayama University kn-affil= en-keyword=COVID-19 kn-keyword=COVID-19 en-keyword=SARS-CoV-2 kn-keyword=SARS-CoV-2 en-keyword=vaccine kn-keyword=vaccine en-keyword=Spanish flu kn-keyword=Spanish flu en-keyword=influenza kn-keyword=influenza END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=2 article-no= start-page=373 end-page=381 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220420 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Development of a Spiral Shaped Soft Holding Actuator Using Extension Type Flexible Pneumatic Actuators en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recently, several pneumatic soft actuators have been applied to wearable and welfare devices to provide nursing care and physical support for the elderly and disabled. In this study, as a wearable soft actuator for holding body, a spiral shaped soft holding actuator that can wrap a user according to their body shape was proposed and tested. The construction and operating principle of the tested soft actuator with circumferential restraint mechanism using three extension type flexible pneumatic actuators (EFPAs) has been discussed. As a result, it was found that the tested actuator could hold elbows and knees when the joint is in motion. An analytical model of the spiral actuator was also proposed to achieve an optimal design. It can be confirmed that the proposed analytical model can predict the shape of the actuator when various EFPAs are pressurized. en-copyright= kn-copyright= en-aut-name=ShimookaSo en-aut-sei=Shimooka en-aut-mei=So kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AkagiTetsuya en-aut-sei=Akagi en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=DohtaShujiro en-aut-sei=Dohta en-aut-mei=Shujiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShinoharaTakashi en-aut-sei=Shinohara en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KobayashiTakumi en-aut-sei=Kobayashi en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Department of Intelligent Mechanical Engineering, Okayama University of Science kn-affil= affil-num=3 en-affil=Department of Intelligent Mechanical Engineering, Okayama University of Science kn-affil= affil-num=4 en-affil=Design and Manufacturing Center, Organization for Research Development and Outreach, Okayama University of Science kn-affil= affil-num=5 en-affil=Department of Intelligent Mechanical Engineering, Okayama University of Science kn-affil= en-keyword=spiral shaped soft holding actuator kn-keyword=spiral shaped soft holding actuator en-keyword=extension type flexible pneumatic actuator kn-keyword=extension type flexible pneumatic actuator en-keyword=circumference restraint mechanism kn-keyword=circumference restraint mechanism en-keyword=analytical model kn-keyword=analytical model END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=6 article-no= start-page=3300 end-page=3308 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220126 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Flame retardance-donated lignocellulose nanofibers (LCNFs) by the Mannich reaction with (amino-1,3,5-triazinyl)phosphoramidates and their properties en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nitrogen/phosphorus-containing melamines (NPCM), a durable flame-retardant, were prepared by the successive treatment of ArOH (Ar = BrnC6H5−n, n = 0, 1, 2, and 3) with POCl3 and melamine monomer. The prepared flame-retardants were grafted through the CH2 unit to lignocellulose nanofibers (LCNFs) by the Mannich reaction. The resulting three-component products were characterized using FT-IR (ATR) and EA. The thermal behavior of the NPCM-treated LCNF fabric samples was determined using TGA and DSC analyses, and their flammability resistances were evaluated by measuring their Limited Oxygen Index (LOI) and the UL-94V test. A multitude of flame retardant elements in the fabric samples increased the LOI values as much as 45 from 20 of the untreated LCNFs. Moreover, the morphology of both the NPCM-treated LCNFs and their burnt fabrics was studied with a scanning electron microscope (SEM). The heat release lowering effect of the LCNF fabric against the water-based paint was observed with a cone calorimeter. Furthermore, the mechanical properties represented as the tensile strength of the NPCM-treated LCNF fabrics revealed that the increase of the NPCM content in the PP-composites led to an increased bending strength with enhancing the flame-retardance. en-copyright= kn-copyright= en-aut-name=OnoFumiaki en-aut-sei=Ono en-aut-mei=Fumiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkiharaTakumi en-aut-sei=Okihara en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OsakaNoboru en-aut-sei=Osaka en-aut-mei=Noboru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NagaokaNoriyuki en-aut-sei=Nagaoka en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KameokaYuji en-aut-sei=Kameoka en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IshikawaAkira en-aut-sei=Ishikawa en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OokiHironari en-aut-sei=Ooki en-aut-mei=Hironari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ItoTakumi en-aut-sei=Ito en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TodomeDaisuke en-aut-sei=Todome en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=UemotoShinya en-aut-sei=Uemoto en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FurutaniMitsuaki en-aut-sei=Furutani en-aut-mei=Mitsuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=InokuchiTsutomu en-aut-sei=Inokuchi en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=OkadaKenji en-aut-sei=Okada en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Okayama Biomass Innovation Creative Center kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Science, Okayama University of Science kn-affil= affil-num=4 en-affil=Advanced Research Center for Oral and Craniofacial Science, Okayama University Dental School kn-affil= affil-num=5 en-affil=Marubishi Oil Chemical Co., Ltd kn-affil= affil-num=6 en-affil=Marubishi Oil Chemical Co., Ltd kn-affil= affil-num=7 en-affil=Gen Gen Corporation kn-affil= affil-num=8 en-affil=Gen Gen Corporation kn-affil= affil-num=9 en-affil=Faculty of Science, Okayama University of Science kn-affil= affil-num=10 en-affil=Okayama Biomass Innovation Creative Center kn-affil= affil-num=11 en-affil=Okayama Biomass Innovation Creative Center kn-affil= affil-num=12 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=13 en-affil=Department of Life Science, Kurashiki University of Science & the Arts kn-affil= END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue= article-no= start-page=82024 end-page=82036 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230803 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Design and Analysis of Hybrid-Excitation Variable Flux Memory Motor for Traction Applications: Improving Output Power in High-Speed Area During Six-Step Operation Mode en-subtitle= kn-subtitle= en-abstract= kn-abstract=Variable flux motors with adjustable magnetic flux have been gaining attention because of their capability to simultaneously achieve a high torque density and high efficiency. In addition, the output power characteristic, which is related to acceleration performance, in high-speed areas is important in traction applications. However, typical traction motors have lower output power in high-speed areas. In this paper, a Hybrid-Excitation Variable Flux Memory Motor (HE-VFMM) is therefore proposed to enhance output power characteristics under six-step operation mode in high-speed area. The proposed HE-VFMM can perform magnetic flux adjustment with two components: field winding and variable flux permanent magnet (VPM), thus dramatically increasing flux adjustment range. The simulation results show the proposed HE-VFMM achieves 23.7% higher output power at 17,000 rpm than that of an existing traction motor in Prius 4th generation that has the same size while maintaining high efficiency in the frequently used operating area. Additionally, it was found that variable magnetic flux is very effective in enhancing the output power, especially in the high-speed region because the magnetic saturation in the stator core is mitigated by field-weakening control. Consequently, as the rotational speed increases, an increase ratio of the output power caused by the adjustable magnetic flux becomes higher. This paper shows that the proposed HE-VFMM is an effective method for improving the problem of low output power in high-speed regions in traction motors. en-copyright= kn-copyright= en-aut-name=TsunataRen en-aut-sei=Tsunata en-aut-mei=Ren kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YokomichiKeito en-aut-sei=Yokomichi en-aut-mei=Keito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakemotoMasatsugu en-aut-sei=Takemoto en-aut-mei=Masatsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ImaiJun en-aut-sei=Imai en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Variable flux memory motor kn-keyword=Variable flux memory motor en-keyword=hybrid excitation motor kn-keyword=hybrid excitation motor en-keyword=traction applications kn-keyword=traction applications en-keyword=EV kn-keyword=EV en-keyword=HEV kn-keyword=HEV en-keyword=six-step operation kn-keyword=six-step operation en-keyword=one-pulse drive kn-keyword=one-pulse drive en-keyword=output power density kn-keyword=output power density END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=4 article-no= start-page=415 end-page=422 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Immunohistochemical Expression of Placental Vitamin D Receptors in Pregnancies Complicated by Early and Late-Onset Preeclampsia en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aim of our study was to determine whether the immunohistochemical expression of placental vitamin D receptors is altered in pregnancies complicated by preeclampsia. Vitamin D receptor expression was immunohistochemically analysed in the placentas of three groups: a control group, and early- and late-onset preeclampsia groups. Total immunohistochemical intensity staining of placentas showed that the control group had a median vitamin D receptor (VDR) expression significantly higher than the placentas of mothers with early- and late-onset preeclampsia. There was no difference among the three groups in a semiquantitative analysis of VDR staining of the stroma only. Vitamin D receptors showed lower median expression in preeclampsia-affected pregnancies, especially early-onset preeclampsia. Therefore, Vitamin D receptor expression may be an important marker for normal placentation and preeclampsia onset. en-copyright= kn-copyright= en-aut-name=JelcicDzenis en-aut-sei=Jelcic en-aut-mei=Dzenis kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=PuzovicVelibor en-aut-sei=Puzovic en-aut-mei=Velibor kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=BenzonBenjamin en-aut-sei=Benzon en-aut-mei=Benjamin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=PaladaIvan en-aut-sei=Palada en-aut-mei=Ivan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=JerkovićJelena en-aut-sei=Jerković en-aut-mei=Jelena kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=VulicMarko en-aut-sei=Vulic en-aut-mei=Marko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Gynecology and Obstetrics, University Hospital of Split kn-affil= affil-num=2 en-affil=General Hospital Dubrovnik, Department of Pathology and Cytology kn-affil= affil-num=3 en-affil=University of Split School of Medicine kn-affil= affil-num=4 en-affil=University Department of Health Studies of the University of Split kn-affil= affil-num=5 en-affil=Department of Gynecology and Obstetrics, University Hospital of Split kn-affil= affil-num=6 en-affil=Department of Gynecology and Obstetrics, University Hospital of Split kn-affil= en-keyword=vitamin D receptor kn-keyword=vitamin D receptor en-keyword=immunohistochemistry kn-keyword=immunohistochemistry en-keyword=early and late-onset preeclampsia kn-keyword=early and late-onset preeclampsia END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=4 article-no= start-page=395 end-page=405 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association of Tumor Necrosis Factor-Alpha with Psychopathology in Patients with Schizophrenia en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia. en-copyright= kn-copyright= en-aut-name=PavlovicMarko en-aut-sei=Pavlovic en-aut-mei=Marko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=BabicDragan en-aut-sei=Babic en-aut-mei=Dragan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=RastovicPejana en-aut-sei=Rastovic en-aut-mei=Pejana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ArapovicJurica en-aut-sei=Arapovic en-aut-mei=Jurica kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MartinacMarko en-aut-sei=Martinac en-aut-mei=Marko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=JakovacSanja en-aut-sei=Jakovac en-aut-mei=Sanja kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=BarbaricRomana en-aut-sei=Barbaric en-aut-mei=Romana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=University Hospital Center Mostar, University of Mostar kn-affil= affil-num=2 en-affil=University Hospital Center Mostar, University of Mostar kn-affil= affil-num=3 en-affil=University Hospital Center Mostar, University of Mostar kn-affil= affil-num=4 en-affil=University Hospital Center Mostar, University of Mostar kn-affil= affil-num=5 en-affil=Health Care Center Mostar, University of Mostar kn-affil= affil-num=6 en-affil=University Hospital Center Mostar, University of Mostar kn-affil= affil-num=7 en-affil=University Hospital Center Mostar, University of Mostar kn-affil= en-keyword=tumor necrosis factor-alpha kn-keyword=tumor necrosis factor-alpha en-keyword=schizophrenia kn-keyword=schizophrenia en-keyword=psychopathology kn-keyword=psychopathology en-keyword=immune system kn-keyword=immune system END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=4 article-no= start-page=365 end-page=370 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=GATA4 rs61277615, rs73203482, and rs35813172 in Newborns with Transposition of the Great Arteries en-subtitle= kn-subtitle= en-abstract= kn-abstract=Congenital heart disease is the most common malformative pathology in newborns, with a worldwide incidence at 0.4-5%. We investigated the possible relationship between variations in nucleotide sequences and specific cardiac malformations in the GATA-binding factor 4 (GATA4) exon 1 region by using Sanger sequencing. Forty-four newborns from a third-level neonatal intensive care unit who were diagnosed with nonsyndromic, ductal-dependent congenital heart disease (i.e., transposition of the great arteries or ductal-dependent coarctation of the aorta) were enrolled. Their DNA was extracted using commercial methods and tested using the multiplex ligation-dependent probe amplification (MLPA) technique. The Sanger sequencing for GATA4 exon 1 in the newborns’ DNA identified rs61277615, rs73203482, and rs35813172 variants not reported in the ClinVar archive of human variations in newborns previously diagnosed with transposition of the great arteries (n=5) and coarctation of the aorta (n=1). The identification of these novel variants in newborns with transposition of the great arteries or ductal-dependent coarctation of the aorta may be the first step in determining the variants’ contribution to the occurrence of congenital heart disease. However, these results may be inconclusive, since the observed variants within GATA4 gene were not previously reported. en-copyright= kn-copyright= en-aut-name=MoldovanElena en-aut-sei=Moldovan en-aut-mei=Elena kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=BănescuClaudia en-aut-sei=Bănescu en-aut-mei=Claudia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=CucereaManuela en-aut-sei=Cucerea en-aut-mei=Manuela kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoldovanValeriu en-aut-sei=Moldovan en-aut-mei=Valeriu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=GozarLiliana en-aut-sei=Gozar en-aut-mei=Liliana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=PușcașiuLucian en-aut-sei=Pușcașiu en-aut-mei=Lucian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Pediatric Intensive Care Unit, Cardiovascular and Transplant Emergency Institute of Târgu Mureș kn-affil= affil-num=2 en-affil=George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș kn-affil= affil-num=3 en-affil=George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș kn-affil= affil-num=4 en-affil=Târgu Mureș County Emergency Clinical Hospital kn-affil= affil-num=5 en-affil=George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș kn-affil= affil-num=6 en-affil=George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș kn-affil= en-keyword=transposition of the great arteries kn-keyword=transposition of the great arteries en-keyword=ductal-dependent coarctation of the aorta kn-keyword=ductal-dependent coarctation of the aorta en-keyword=GATA4 kn-keyword=GATA4 en-keyword=MLPA kn-keyword=MLPA en-keyword=Sanger sequencing kn-keyword=Sanger sequencing END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=1 article-no= start-page=21 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Questionnaire Survey on COVID-19 Vaccination at Okayama University in Japan: Factors Promoting Vaccination Among Young Adults en-subtitle= kn-subtitle= en-abstract= kn-abstract=COVID-19 has been prevalent worldwide since 2019. Increasing COVID-19 vaccination coverage is an important measure to combat the disease. An online survey was conducted with university students and personnel who were vaccinated against COVID-19 at a mass vaccination event to examine the factors promoting vaccination among young adults. The online survey was conducted with persons vaccinated at Okayama University from June 5 to September 27, 2021. Although the number of those who had fever >37.5°C increased after the second vaccination compared to the first, the vaccinated persons got more satisfied after the second shot. en-copyright= kn-copyright= en-aut-name=HiguchiChigusa en-aut-sei=Higuchi en-aut-mei=Chigusa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoNaomi en-aut-sei=Matsumoto en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IwasakiYoshiaki en-aut-sei=Iwasaki en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamazakiJunichiro en-aut-sei=Yamazaki en-aut-mei=Junichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NasuYasutomo en-aut-sei=Nasu en-aut-mei=Yasutomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Okayama University Health Service Center kn-affil= affil-num=2 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Okayama University Health Service Center kn-affil= affil-num=4 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Okayama University kn-affil= affil-num=6 en-affil=Okayama University kn-affil= affil-num=7 en-affil=Okayama University kn-affil= en-keyword=COVID-19 vaccine kn-keyword=COVID-19 vaccine en-keyword=vaccine hesitancy kn-keyword=vaccine hesitancy en-keyword=young adults kn-keyword=young adults en-keyword=information literacy kn-keyword=information literacy en-keyword=satisfaction kn-keyword=satisfaction END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=1 article-no= start-page=7 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effectiveness of and Immune Responses to SARS-CoV-2 mRNA Vaccines and Their Mechanisms en-subtitle= kn-subtitle= en-abstract= kn-abstract=Following the online publication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome in January 2020, two lipid nanoparticle-encapsulated mRNA vaccines, BNT162b2 and mRNA-1273, were rapidly developed and are now being used worldwide to prevent coronavirus disease 2019 (COVID-19). The mRNA of both vaccines encodes the full-length spike protein of SARS-CoV-2, which binds to the host cell receptor angiotensin-converting enzyme 2 and is believed to mediate virus entry into cells. After intramuscular injection of the vaccine, the spike protein is produced in the cells. Both humoral and cellular immune responses to the spike protein are elicited for protection against COVID-19. The efficacy of the two mRNA vaccines against COVID-19 with wild-type SARS-CoV-2 is more than 90% and is slightly decreased with the Delta variant, which is currently the predominant variant in many countries. In this review, the effectiveness of and immune responses to COVID-19 mRNA vaccines and their mechanisms are summarized and discussed. Potential waning immunity and an additional dose of COVID-19 mRNA vaccines are also discussed. en-copyright= kn-copyright= en-aut-name=GohdaEiichi en-aut-sei=Gohda en-aut-mei=Eiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Okayama University kn-affil= en-keyword=COVID-19 kn-keyword=COVID-19 en-keyword=SARS-CoV-2 kn-keyword=SARS-CoV-2 en-keyword=mRNA vaccine kn-keyword=mRNA vaccine en-keyword=immune response kn-keyword=immune response END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue= article-no= start-page=52750 end-page=52762 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230529 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Stargazer: Long-Term and Multiregional Measurement of Timing/ Geolocation-Based Cloaking en-subtitle= kn-subtitle= en-abstract= kn-abstract=Malicious hosts have come to play a significant and varied role in today's cyber attacks. Some of these hosts are equipped with a technique called cloaking, which discriminates between access from potential victims and others and then returns malicious content only to potential victims. This is a serious threat because it can evade detection by security vendors and researchers and cause serious damage. As such, cloaking is being extensively investigated, especially for phishing sites. We are currently engaged in a long-term cloaking study of a broader range of threats. In the present study, we implemented Stargazer, which actively monitors malicious hosts and detects geographic and temporal cloaking, and collected 30,359,410 observations between November 2019 and February 2022 for 18,397 targets from 13 sites where our sensors are installed. Our analysis confirmed that cloaking techniques are widely abused, i.e., not only in the context of specific threats such as phishing. This includes geographic and time-based cloaking, which is difficult to detect with single-site or one-shot observations. Furthermore, we found that malicious hosts that perform cloaking include those that survive for relatively long periods of time, and those whose contents are not present in VirusTotal. This suggests that it is not easy to observe and analyze the cloaking malicious hosts with existing technologies. The results of this study have deepened our understanding of various types of cloaking, including geographic and temporal ones, and will help in the development of future cloaking detection methods. en-copyright= kn-copyright= en-aut-name=FujiiShota en-aut-sei=Fujii en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SatoTakayuki en-aut-sei=Sato en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AokiSho en-aut-sei=Aoki en-aut-mei=Sho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TsudaYu en-aut-sei=Tsuda en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawaguchiNobutaka en-aut-sei=Kawaguchi en-aut-mei=Nobutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShigemotoTomohiro en-aut-sei=Shigemoto en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TeradaMasato en-aut-sei=Terada en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Research and Development Group, Hitachi Ltd. kn-affil= affil-num=3 en-affil=Research and Development Group, Hitachi Ltd. kn-affil= affil-num=4 en-affil=National Institute of Information and Communications Technology kn-affil= affil-num=5 en-affil=Research and Development Group, Hitachi Ltd. kn-affil= affil-num=6 en-affil=Research and Development Group, Hitachi Ltd. kn-affil= affil-num=7 en-affil=Research and Development Group, Hitachi Ltd. kn-affil= en-keyword=Cloaking kn-keyword=Cloaking en-keyword=cyber security kn-keyword=cyber security en-keyword=geofencing kn-keyword=geofencing en-keyword=malcious host kn-keyword=malcious host en-keyword=time-series kn-keyword=time-series END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue=2 article-no= start-page=85 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Objective evaluation method using multiple image analyses for panoramic radiography improvement en-subtitle= kn-subtitle= en-abstract= kn-abstract=Introduction: In the standardization of panoramic radiography quality, the education and training of beginners on panoramic radiographic imaging are important. We evaluated the relationship between positioning error factors and multiple image analysis results for reproducible panoramic radiography.
Material and methods: Using a panoramic radiography system and a dental phantom, reference images were acquired on the Frankfurt plane along the horizontal direction, midsagittal plane along the left-right direction, and for the canine on the forward-backward plane. Images with positioning errors were acquired with 1-5 mm shifts along the forward-backward direction and 2-10 degrees rotations along the horizontal (chin tipped high/low) and vertical (left-right side tilt) directions on the Frankfurt plane. The cross-correlation coefficient and angle difference of the occlusion congruent plane profile between the reference and positioning error images, peak signal-to-noise ratio (PSNR), and deformation vector value by deformable image registration were compared and evaluated.
Results: The cross-correlation coefficients of the occlusal plane profiles showed the greatest change in the chin tipped high images and became negatively correlated from 6 degrees image rotation (r = -0.29). The angle difference tended to shift substantially with increasing positioning error, with an angle difference of 8.9 degrees for the 10 degrees chin tipped low image. The PSNR was above 30 dB only for images with a 1-mm backward shift. The positioning error owing to the vertical rotation was the largest for the deformation vector value.
Conclusions: Multiple image analyses allow to determine factors contributing to positioning errors in panoramic radiography and may enable error correction. This study based on phantom imaging can support the education of beginners regarding panoramic radiography. en-copyright= kn-copyright= en-aut-name=ImajoSatoshi en-aut-sei=Imajo en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanabeYoshinori en-aut-sei=Tanabe en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakamuraNobue en-aut-sei=Nakamura en-aut-mei=Nobue kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HondaMitsugi en-aut-sei=Honda en-aut-mei=Mitsugi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Division of Radiology, Medical Support Department, Okayama University Hospital kn-affil= affil-num=4 en-affil=Division of Radiology, Medical Support Department, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= en-keyword=panoramic radiography kn-keyword=panoramic radiography en-keyword=quantitative evaluation kn-keyword=quantitative evaluation en-keyword=deformable image registration kn-keyword=deformable image registration en-keyword=peak signal-to-noise ratio kn-keyword=peak signal-to-noise ratio END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=3 article-no= start-page=311 end-page=318 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Current Femoral Stem Fixation Selection in Hip-Fracture Bipolar Hemiarthroplasties, and Factors Affecting Surgeons’ Confidence in Their Ability to Teach about Cemented Stems: A Questionnaire in a Region of Japan with Super-Aged Patients en-subtitle= kn-subtitle= en-abstract= kn-abstract=Japan’s hip fracture management guidelines now recommend the use of cemented stems in cases of bone fragility. However, the current stem selection practices in bipolar hemiarthroplasty (BHA) in a super-aging area in Japan remain unclear. This study aimed to examine the stem selection policies, the surgeons’ concerns about cemented stems, and factors affecting their confidence in their ability to coach others on cemented stem procedures. Ninety-four orthopedic surgeons (27 facilities) responded to our web-based questionnaire conducted in January/February 2022. Cementless stem was the first choice of 97.8% of the surgeons; <15% of the respondents expected to increase their use of cemented stems in the future. The cement technique was the greatest concern; almost half of the surgeons described having insufficient experience with cemented stems. The factor that most affected the surgeons’ expertise in using cemented stems is the number of surgeries they had conducted with a cemented stem (multivariable analysis odds ratio 8.42, p=0.001). Greater experience was associated with increased expertise of the surgeons in using cemented stems, with a threshold of 11 cases showing sensitivity of 41.7% and specificity of 98.3% for their confidence to instruct cemented stems. en-copyright= kn-copyright= en-aut-name=MiuraTakanori en-aut-sei=Miura en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KijimaHiroaki en-aut-sei=Kijima en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TazawaHiroshi en-aut-sei=Tazawa en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyakoshiNaohisa en-aut-sei=Miyakoshi en-aut-mei=Naohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Orthopedic Surgery, Tazawako Hospital kn-affil= affil-num=2 en-affil=Akita Hip Research Group, Akita University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Akita Hip Research Group, Akita University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Akita Hip Research Group, Akita University Graduate School of Medicine kn-affil= en-keyword=hip fracture kn-keyword=hip fracture en-keyword=arthroplasty kn-keyword=arthroplasty en-keyword=bone cement kn-keyword=bone cement en-keyword=questionnaire kn-keyword=questionnaire END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue=1 article-no= start-page=65 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ERRATA: FDM simulation of long-period ground motions around Oita Prefecture, Japan, using a land-ocean unified 3D structure model kn-title=訂正：地形を考慮した陸海統合3次元地震波速度構造モデルを用いた大分県周辺の長周期地震動シミュレーション en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OKUNAKATatsuya en-aut-sei=OKUNAKA en-aut-mei=Tatsuya kn-aut-name=奥仲達也 kn-aut-sei=奥仲 kn-aut-mei=達也 aut-affil-num=1 ORCID= en-aut-name=KOMATSUMasanao en-aut-sei=KOMATSU en-aut-mei=Masanao kn-aut-name=小松正直 kn-aut-sei=小松 kn-aut-mei=正直 aut-affil-num=2 ORCID= en-aut-name=TAKENAKAHiroshi en-aut-sei=TAKENAKA en-aut-mei=Hiroshi kn-aut-name=竹中博士 kn-aut-sei=竹中 kn-aut-mei=博士 aut-affil-num=3 ORCID= en-aut-name=YOSHIMIMasayuki en-aut-sei=YOSHIMI en-aut-mei=Masayuki kn-aut-name=吉見雅行 kn-aut-sei=吉見 kn-aut-mei=雅行 aut-affil-num=4 ORCID= en-aut-name=NAKAMURATakeshi en-aut-sei=NAKAMURA en-aut-mei=Takeshi kn-aut-name=中村武史 kn-aut-sei=中村 kn-aut-mei=武史 aut-affil-num=5 ORCID= en-aut-name=OKAMOTOTaro en-aut-sei=OKAMOTO en-aut-mei=Taro kn-aut-name=岡元太郎 kn-aut-sei=岡元 kn-aut-mei=太郎 aut-affil-num=6 ORCID= affil-num=1 en-affil=Formerly Department of Earth Sciences, Okayama University kn-affil=元・岡山大学理学部地球科学科 affil-num=2 en-affil=Department of Earth Sciences, Okayama University kn-affil=岡山大学大学院自然科学研究科 affil-num=3 en-affil=Department of Earth Sciences, Okayama University kn-affil=岡山大学学術研究院自然科学学域 affil-num=4 en-affil=Geological Survey of Japan, National Institute of Advanced Industrial Science and Technology kn-affil=国立研究開発法人産業技術総合研究所 活断層・火山研究部門 affil-num=5 en-affil=Formerly Japan Agency for Marine-Earth Science and Technology kn-affil=元・国立研究開発法人海洋研究開発機構 affil-num=6 en-affil=Department of Earth and Planetary Sciences, School of Science, Tokyo Institute of Technology kn-affil=東京工業大学理学院地球惑星科学系 END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue= article-no= start-page=39466 end-page=39483 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230413 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Artificial Neural Network Based Audio Reinforcement for Computer Assisted Rote Learning en-subtitle= kn-subtitle= en-abstract= kn-abstract=The dual-channel assumption of the cognitive theory of multimedia learning suggests that importing a large amount of information through a single (visual or audio) channel overloads that channel, causing partial loss of information, while importing it simultaneously through multiple channels relieves the burden on them and leads to the registration of a larger amount of information. In light of such knowledge, this study investigates the possibility of reinforcing visual stimuli with audio for supporting e-learners in memorization tasks. Specifically, we consider three kinds of learning material and two kinds of audio stimuli and partially reinforce each kind of material with each kind of stimuli in an arbitrary way. In a series of experiments, we determine the particular type of audio, which offers the highest improvement for each kind of material. Our work stands out as being the first study investigating the differences in memory performance in relation to different combinations of learning content and stimulus. Our key findings from the experiments are: (i) E-learning is more effective in refreshing memory rather than studying from scratch, (ii) Non-informative audio is more suited to verbal content, whereas informative audio is better for numerical content, (iii) Constant audio triggering degrades learning performance and thus audio triggering should be handled with care. Based on these findings, we develop an ANN-based estimator to determine the proper moment for triggering audio (i.e. when memory performance is estimated to be declining) and carry out follow-up experiments for testing the integrated framework. Our contributions involve (i) determination of the most effective audio for each content type, (ii) estimation of memory deterioration based on learners' interaction logs, and (iii) the proposal of improvement of memory registration through auditory reinforcement. We believe that such findings constitute encouraging evidence the memory registration of e-learners can be enhanced with content-aware audio incorporation. en-copyright= kn-copyright= en-aut-name=SupitayakulParisa en-aut-sei=Supitayakul en-aut-mei=Parisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YücelZeynep en-aut-sei=Yücel en-aut-mei=Zeynep kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MondenAkito en-aut-sei=Monden en-aut-mei=Akito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Visualization kn-keyword=Visualization en-keyword=Electronic learning kn-keyword=Electronic learning en-keyword=Task analysis kn-keyword=Task analysis en-keyword=Estimation kn-keyword=Estimation en-keyword=Vocabulary kn-keyword=Vocabulary en-keyword=Memory management kn-keyword=Memory management en-keyword=Learning (artificial intelligence) kn-keyword=Learning (artificial intelligence) en-keyword=E-learning kn-keyword=E-learning en-keyword=neural networks kn-keyword=neural networks en-keyword=artificial intelligence kn-keyword=artificial intelligence en-keyword=cognitive theory of multimedia learning kn-keyword=cognitive theory of multimedia learning en-keyword=cognitive load kn-keyword=cognitive load en-keyword=distinctiveness account kn-keyword=distinctiveness account en-keyword=perceptual decoupling kn-keyword=perceptual decoupling en-keyword=adaptability kn-keyword=adaptability en-keyword=educational data mining kn-keyword=educational data mining END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=2 article-no= start-page=147 end-page=159 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Personalized Preclinical Training in Dental Ergonomics and Endodontics in Undergraduate Dentistry Students (Pilot Study) en-subtitle= kn-subtitle= en-abstract= kn-abstract=The curriculum at the Department of Pathophysiology in the Periodontal Sciences program at Okayama University includes normative preclinical training (NPT) using phantoms. NPT is given to the whole class of 5 th year students divided in groups of 8 students/instructor. In 2019, an innovative personalized preclinical training (PPT) pilot study was implemented for this group of students whereby two students, each with their own dental unit, were coached by one instructor. The main topics covered were dental ergonomics and endodontics. We aimed to evaluate the effectiveness of PPT in dental ergonomics and endodontics toward increasing the knowledge and future clinical skills of students who had already undergone NPT. A test on endodontics was taken before and after PPT. A questionnaire was completed to assess their perception of improvement regarding the above-mentioned topics. Test scores and questionnaire results both showed that the students’ level of knowledge and awareness of future clinical skills was significantly higher after PPT. This pilot study demonstrated that PPT increased the students’ knowledge and future clinical skills. As preclinical training forms the foundation for clinical practice, investment in future research regarding this personalized approach is likely to enhance students’ understanding and clinical performance. en-copyright= kn-copyright= en-aut-name=AriasZulema en-aut-sei=Arias en-aut-mei=Zulema kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HainesStephanie en-aut-sei=Haines en-aut-mei=Stephanie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamamotoTadashi en-aut-sei=Yamamoto en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HatanakaKazu en-aut-sei=Hatanaka en-aut-mei=Kazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamashiroKeisuke en-aut-sei=Yamashiro en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SonoiNorihiro en-aut-sei=Sonoi en-aut-mei=Norihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakashibaShogo en-aut-sei=Takashiba en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Health kn-affil= affil-num=3 en-affil=Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, kn-affil= affil-num=4 en-affil=Department of Periodontics and Endodontics, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Periodontics and Endodontics, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Periodontics and Endodontics, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=preclinical personalized education kn-keyword=preclinical personalized education en-keyword=dental ergonomics kn-keyword=dental ergonomics en-keyword=endodontics kn-keyword=endodontics en-keyword=clinical skills improvement kn-keyword=clinical skills improvement en-keyword=undergraduate students kn-keyword=undergraduate students END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=1 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230224 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Attributable fraction and related measures: Conceptual relations in the counterfactual framework en-subtitle= kn-subtitle= en-abstract= kn-abstract=The attributable fraction (population) has attracted much attention from a theoretical perspective and has been used extensively to assess the impact of potential health interventions. However, despite its extensive use, there is much confusion about its concept and calculation methods. In this article, we discuss the concepts of and calculation methods for the attributable fraction and related measures in the counterfactual framework, both with and without stratification by covariates. Generally, the attributable fraction is useful when the exposure of interest has a causal effect on the outcome. However, it is important to understand that this statement applies to the exposed group. Although the target population of the attributable fraction (population) is the total population, the causal effect should be present not in the total population but in the exposed group. As related measures, we discuss the preventable fraction and prevented fraction, which are generally useful when the exposure of interest has a preventive effect on the outcome, and we further propose a new measure called the attributed fraction. We also discuss the causal and preventive excess fractions, and provide notes on vaccine efficacy. Finally, we discuss the relations between the aforementioned six measures and six possible patterns using a conceptual schema. en-copyright= kn-copyright= en-aut-name=SuzukiEtsuji en-aut-sei=Suzuki en-aut-mei=Etsuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamamotoEiji en-aut-sei=Yamamoto en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Okayama University of Science kn-affil= en-keyword=attributable fraction kn-keyword=attributable fraction en-keyword=counterfactual model kn-keyword=counterfactual model en-keyword=excess fraction kn-keyword=excess fraction en-keyword=preventable fraction kn-keyword=preventable fraction en-keyword=prevented fraction kn-keyword=prevented fraction en-keyword=vaccine efficacy kn-keyword=vaccine efficacy END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=1 article-no= start-page=75 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202302 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Scattered Tiny Whitish Protrusions in the Stomach Are a Clue to the Diagnosis of Autoimmune Gastritis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Herein, we report two patients with autoimmune gastritis who had undergone multiple esophagogastroduodenoscopy procedures for 17 and 9 years, respectively, before their diagnosis. Instead, they had been diagnosed with and treated for Helicobacter pylori-associated gastritis. The correct diagnosis was made when scatterings of tiny whitish protrusions in the gastric mucosa were detected on esophagogastroduodenoscopy. Our findings suggest that scattered tiny whitish bumps may be a clue to the diagnosis of autoimmune gastritis. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HamadaKenta en-aut-sei=Hamada en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KonoYoshiyasu en-aut-sei=Kono en-aut-mei=Yoshiyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KanzakiHiromitsu en-aut-sei=Kanzaki en-aut-mei=Hiromitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Practical Gastrointestinal Endoscopy, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=autoimmune gastritis kn-keyword=autoimmune gastritis en-keyword=esophagogastroduodenoscopy kn-keyword=esophagogastroduodenoscopy en-keyword=scattered lesions kn-keyword=scattered lesions en-keyword=small white protrusions kn-keyword=small white protrusions en-keyword=mucosal lesions kn-keyword=mucosal lesions END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=6 article-no= start-page=715 end-page=721 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Graphene Oxide-based Endodontic Sealer: An in Vitro Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=The failure of endodontic treatment is directly associated with microbial infection in the root canal or periapical areas. An endodontic sealer that is both bactericidal and biocompatible is essential for the success of root canal treatments. This is one of the vital issues yet to be solved in clinical dental practice. This in vitro study assessed the effectiveness of graphene oxide (GO) composites GO-CaF2 and GO-Ag-CaF2 as endodontic sealer materials. Dentin slices were coated with either the GO-based composites or commonly used root canal sealers (non-eugenol zinc oxide sealer). The coated slices were treated in 0.9% NaCl, phosphate-buffered saline (PBS), and simulated body fluid (SBF) at 37˚C for 24 hours to compare their sealing effect on the dentin surface. In addition, the radiopacity of these composites was examined to assess whether they complied with the requirements of a sealer for good radiographic visualization. Scanning electron microscopy showed the significant sealing capability of the composites as coating materials. Radiographic images confirmed their radiopacity. Mineral deposition indicated their bioactivity, especially of GO-Ag-CaF2, and thus it is potential for regenerative application. They were both previously shown to be bactericidal to oral microbes and cytocompatible with host cells. With such a unique assemblage of critical properties, these GO-based composites show promise as endodontic sealers for protection against reinfection in root canal treatment and enhanced success in endodontic treatment overall. en-copyright= kn-copyright= en-aut-name=Mohammed Zahedul Islam Nizami en-aut-sei=Mohammed Zahedul Islam Nizami en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=GorduysusMelahat en-aut-sei=Gorduysus en-aut-mei=Melahat kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Shinoda-ItoYuki en-aut-sei=Shinoda-Ito en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamamotoTadashi en-aut-sei=Yamamoto en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NishinaYuta en-aut-sei=Nishina en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakashibaShogo en-aut-sei=Takashiba en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AriasZulema en-aut-sei=Arias en-aut-mei=Zulema kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Pathophysiology – Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Pathophysiology – Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Pathophysiology – Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Pathophysiology – Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Research Core for Interdisciplinary Sciences, Okayama University kn-affil= affil-num=6 en-affil=Research Core for Interdisciplinary Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Pathophysiology – Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=bioactive sealer kn-keyword=bioactive sealer en-keyword=graphene oxide kn-keyword=graphene oxide en-keyword=mineral deposition kn-keyword=mineral deposition en-keyword=antimicrobial activity kn-keyword=antimicrobial activity en-keyword=radiopacity kn-keyword=radiopacity END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=6 article-no= start-page=651 end-page=660 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Intraoperative Hypothermia Is Not Associated with Surgical Site Infections after Total Hip or Knee Arthroplasty en-subtitle= kn-subtitle= en-abstract= kn-abstract=Maintaining perioperative normothermia decreases the post-surgery surgical site infection (SSI) rate. We investigated whether SSI is associated with intraoperative hypothermia in total hip (THA) and total knee (TKA) arthroplasties by retrospectively analyzing 297 THA and TKA cases. The patients’ intraoperative core body temperature (BT) was measured by bladder catheter or forehead sensor. We evaluated the associations between SSI and intraoperative BT and other variables and patient characteristics. Fifty-six patients (18.8%) had hypothermia (BT <36°C); 43 developed SSI (14.5%); only five had hypothermia (11.6%). Intraoperative hypothermia and SSI were not significantly associated. The SSI group had more men (34.9% vs. 18.1%) and THA patients (77.4%), a longer mean surgical duration (174.3 vs. 143.5 mins), and a higher average BT (36.4°C vs. 36.2°C) than the no-SSI group. The SSI patients had a higher intraoperative BT. A multivariable analysis revealed that SSI was associated with male sex (OR 2.3, 95%CI: 1.031-4.921, p=0.042), longer surgery (OR, 1.01, 95%CI: 1.003-1.017, p=0.004), THA (OR 3.6, 95%CI: 1.258-10.085, p=0.017), and intraoperative BT >36.0°C (OR 3.6, 95%CI: 1.367-9.475, p=0.009). Intraoperative hypothermia was not associated with SSI in adults who underwent THA or TKA. These results suggest that hypothermia might not be the problem for SSI. en-copyright= kn-copyright= en-aut-name=Bright Osman Abugri en-aut-sei=Bright Osman Abugri en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsusakiTakashi en-aut-sei=Matsusaki en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=RenWanxu en-aut-sei=Ren en-aut-mei=Wanxu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MorimatsuHiroshi en-aut-sei=Morimatsu en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Anesthesiology and Resuscitology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Anesthesiology and Resuscitology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Anesthesiology and Resuscitology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Anesthesiology and Resuscitology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=hypothermia kn-keyword=hypothermia en-keyword=surgical site infection kn-keyword=surgical site infection en-keyword=total hip arthroplasty (THA) kn-keyword=total hip arthroplasty (THA) en-keyword=knee arthroplasty (TKA) kn-keyword=knee arthroplasty (TKA) END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=6 article-no= start-page=617 end-page=624 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Artificial Intelligence-based Detection of Epileptic Discharges from Pediatric Scalp Electroencephalograms: A Pilot Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=We developed an artificial intelligence (AI) technique to identify epileptic discharges (spikes) in pediatric scalp electroencephalograms (EEGs). We built a convolutional neural network (CNN) model to automatically classify steep potential images into spikes and background activity. For the CNN model’ training and validation, we examined 100 children with spikes in EEGs and another 100 without spikes. A different group of 20 children with spikes and 20 without spikes were the actual test subjects. All subjects were ≥ 3 to < 18 years old. The accuracy, sensitivity, and specificity of the analysis were >0.97 when referential and combination EEG montages were used, and < 0.97 with a bipolar montage. The correct classification of background activity in individual patients was significantly better with a referential montage than with a bipolar montage (p=0.0107). Receiver operating characteristic curves yielded an area under the curve > 0.99, indicating high performance of the classification method. EEG patterns that interfered with correct classification included vertex sharp transients, sleep spindles, alpha rhythm, and low-amplitude ill-formed spikes in a run. Our results demonstrate that AI is a promising tool for automatically interpreting pediatric EEGs. Some avenues for improving the technique were also indicated by our findings. en-copyright= kn-copyright= en-aut-name=KobayashiKatsuhiro en-aut-sei=Kobayashi en-aut-mei=Katsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShibataTakashi en-aut-sei=Shibata en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsuchiyaHiroki en-aut-sei=Tsuchiya en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AkiyamaTomoyuki en-aut-sei=Akiyama en-aut-mei=Tomoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=neural network kn-keyword=neural network en-keyword=deep learning kn-keyword=deep learning en-keyword=electroencephalogram kn-keyword=electroencephalogram en-keyword=children kn-keyword=children en-keyword=spike kn-keyword=spike END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=5 article-no= start-page=503 end-page=510 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Viral Sequences Are Repurposed for Controlling Antiviral Responses as Non-Retroviral Endogenous Viral Elements en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches. en-copyright= kn-copyright= en-aut-name=OgawaHirohito en-aut-sei=Ogawa en-aut-mei=Hirohito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HondaTomoyuki en-aut-sei=Honda en-aut-mei=Tomoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Virology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Virology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=EVE kn-keyword=EVE en-keyword=nrEVE kn-keyword=nrEVE en-keyword=bornavirus kn-keyword=bornavirus en-keyword=filovirus kn-keyword=filovirus en-keyword=antiviral kn-keyword=antiviral END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=5 article-no= start-page=489 end-page=502 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Current Insights into Mesenchymal Signatures in Glioblastoma en-subtitle= kn-subtitle= en-abstract= kn-abstract=Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives. en-copyright= kn-copyright= en-aut-name=MatsumotoYuji en-aut-sei=Matsumoto en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IchikawaTomotsugu en-aut-sei=Ichikawa en-aut-mei=Tomotsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KurozumiKazuhiko en-aut-sei=Kurozumi en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DateIsao en-aut-sei=Date en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Neurological Surgery, Kagawa Prefectural Central Hospital kn-affil= affil-num=3 en-affil=Department of Neurosurgery, Hamamatsu University Hospital kn-affil= affil-num=4 en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=glioma kn-keyword=glioma en-keyword=glioblastoma kn-keyword=glioblastoma en-keyword=mesenchymal subtype kn-keyword=mesenchymal subtype en-keyword=mesenchymal transition kn-keyword=mesenchymal transition en-keyword=heterogeneity kn-keyword=heterogeneity END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=4 article-no= start-page=465 end-page=472 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Molecular-targeted Therapy for Metastatic Renal Cell Carcinoma As First-line Therapy: A Single Institution 13-year Experience en-subtitle= kn-subtitle= en-abstract= kn-abstract=We aimed to identify the role of first-line monotherapy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKI) in patients with metastatic RCC. Eligible patients were categorized into three groups (favorable, intermediate, and poor risk) according to the International Metastatic RCC Database Consortium risk criteria. Overall survival (OS) was the primary endpoint. Survival was compared using the log-rank test. A total of 108 patients were retrospectively analyzed. The numbers of patients in the favorable-, intermediate-, and poor-risk groups were 32 (30%), 66 (61%), and 10 (9%), repestively. The median OS values in the entire cohort was 36 months (95% confidence interval [CI] 29-53). The median OS in the favorable, intermediate, and poor risk groups were 94 months (95% CI: 43-Not reached), 30 months (95% CI: 20-38), and 8 months (95% CI: 0-Not reached), respectively (p<0.05). Prior nephrectomy, clear cell histology, clinical T stage ≤2, no metastasis at the time of diagnosis, nivolumab beyond first-line therapy, and objective response to VEGFR-TKIs were factors significantly prolonging OS on univariate analysis. VEGFR-TKI monotherapy as first-line therapy was an effective treatment option for patients with metastatic clear cell RCC with favorable risk. en-copyright= kn-copyright= en-aut-name=BekkuKensuke en-aut-sei=Bekku en-aut-mei=Kensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsugawaTakuji en-aut-sei=Tsugawa en-aut-mei=Takuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsuboiKazuma en-aut-sei=Tsuboi en-aut-mei=Kazuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NodaGaku en-aut-sei=Noda en-aut-mei=Gaku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=InoueYousuke en-aut-sei=Inoue en-aut-mei=Yousuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MuraoWataru en-aut-sei=Murao en-aut-mei=Wataru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=EbaraShin en-aut-sei=Ebara en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Urology, Hiroshima City Hiroshima Citizens Hospital kn-affil= affil-num=2 en-affil=Department of Urology, Hiroshima City Hiroshima Citizens Hospital kn-affil= affil-num=3 en-affil=Department of Urology, Hiroshima City Hiroshima Citizens Hospital kn-affil= affil-num=4 en-affil=Department of Urology, Hiroshima City Hiroshima Citizens Hospital kn-affil= affil-num=5 en-affil=Department of Urology, Hiroshima City Hiroshima Citizens Hospital kn-affil= affil-num=6 en-affil=Department of Urology, Hiroshima City Hiroshima Citizens Hospital kn-affil= affil-num=7 en-affil=Department of Urology, Hiroshima City Hiroshima Citizens Hospital kn-affil= en-keyword=metastatic renal cell carcinoma kn-keyword=metastatic renal cell carcinoma en-keyword=molecular-targeted therapy kn-keyword=molecular-targeted therapy en-keyword=immuno-checkpoint inhibitor kn-keyword=immuno-checkpoint inhibitor en-keyword=real-world setting kn-keyword=real-world setting END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=4 article-no= start-page=429 end-page=437 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Association between Preoperative Blood Pressure Elevations and Postoperative Adverse Outcomes after Non-cardiac Surgery: A Single-center Retrospective Observational Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Blood pressure (BP) often rises before surgery. This study investigated whether BP elevation immediately before surgery was associated with adverse outcomes. Medical records of 11,732 patients (average age: 61 years; male: 47.4%) who underwent non-cardiac elective inpatient surgery under general anesthesia at Kagawa University Hospital between January 2011 and June 2019 were reviewed. Differences between the first BP values measured on the day before surgery and the first BP values in the operating room were defined as Δ systolic BP (ΔSBP) and Δ diastolic BP (ΔDBP). The relationships between ΔSBP/ΔDBP and 30-day mortality, 30-day readmission, and over-the-standard length of hospital stay (OSLOS) were assessed. OSLOS was defined as a hospital stay longer than mean+2 standard deviations and was calculated using the Japanese Diagnosis Procedure Combination data. In univariate analysis, the differences in ΔSBP and ΔDBP between the OSLOS and standard LOS groups were both 2 mmHg. In multivariate logistic regression analysis, only ΔDBP was associated with OSLOS. The adjusted odds ratio (95% confidence interval) for the largest quartile was 1.31 (1.02-1.69) (p<0.05). ΔDBP was associated with OSLOS; however, there may be little need to worry about large ΔSBPs and ΔDBPs in clinical practice. en-copyright= kn-copyright= en-aut-name=YamadoriYusuke en-aut-sei=Yamadori en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HiraoTomohiro en-aut-sei=Hirao en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Nlandu R. Ngatu en-aut-sei=Nlandu R. Ngatu en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KandaKanae en-aut-sei=Kanda en-aut-mei=Kanae kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=Syed Mahfuz Al Hasan en-aut-sei=Syed Mahfuz Al Hasan en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MurakamiAkitsu en-aut-sei=Murakami en-aut-mei=Akitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MashimaYukinori en-aut-sei=Mashima en-aut-mei=Yukinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShirakamiGotaro en-aut-sei=Shirakami en-aut-mei=Gotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Anesthesiology, Faculty of Medicine, Kagawa University kn-affil= affil-num=2 en-affil=Department of Public Health, Faculty of Medicine, Kagawa University kn-affil= affil-num=3 en-affil=Department of Public Health, Faculty of Medicine, Kagawa University kn-affil= affil-num=4 en-affil=Department of Public Health, Faculty of Medicine, Kagawa University kn-affil= affil-num=5 en-affil=Department of Public Health, Faculty of Medicine, Kagawa University kn-affil= affil-num=6 en-affil=Department of Anesthesiology, Faculty of Medicine, Kagawa University kn-affil= affil-num=7 en-affil=Department of Public Health, Faculty of Medicine, Kagawa University kn-affil= affil-num=8 en-affil=Department of Anesthesiology, Faculty of Medicine, Kagawa University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=4 article-no= start-page=359 end-page=371 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Therapeutic Approaches Targeting miRNA in Systemic Lupus Erythematosus en-subtitle= kn-subtitle= en-abstract= kn-abstract=Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE. en-copyright= kn-copyright= en-aut-name=Hiramatsu-AsanoSumie en-aut-sei=Hiramatsu-Asano en-aut-mei=Sumie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=systemic lupus erythematosus kn-keyword=systemic lupus erythematosus en-keyword=miRNA kn-keyword=miRNA en-keyword=miRNA targeting therapy kn-keyword=miRNA targeting therapy END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue=5 article-no= start-page=565 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220420 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mechanical Study of Various Pedicle Screw Systems including Percutaneous Pedicle Screw in Trauma Treatment en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background and Objectives: Spine surgery using a percutaneous pedicle screw placement (PPSP) is widely implemented for spinal trauma. However, percutaneous systems have been reported to have weak screw-rod connections. In this study, conventional open and percutaneous systems were biomechanically evaluated and compared. Material and Methods: The experiments were performed in two stages: the first stage was a break test, whereas the second stage was a fatigue test. Four systems were used for the experiments. System 1 was intended for conventional open surgery (titanium rod with a 6.0 mm diameter, using a clamp connecting mechanism). System 2 was a percutaneous pedicle screw (PPS) system for trauma (titanium alloy rod with a 6.0 mm diameter, using ball ring connections). System 3 was a PPS system for trauma (cobalt-chromium alloy rod with a 6.0 mm diameter, using sagittal adjusting screw connections). System 4 was a general-purpose PPS system (titanium alloy rod with a 5.5 mm diameter, using a mechanism where the adapter in the head holds down the screw). Results: Stiffness values of 54.8 N/mm, 43.1 N/mm, 90.9 N/mm, and 39.3 N/mm were reported for systems 1, 2, 3, and 4, respectively. The average number of load cycles in the fatigue test was 134,393, 40,980, 1,550,389, and 147,724 for systems 1 to 4, respectively. At the end of the test, the displacements were 0.2 mm, 16.9 mm, 1.2 mm, and 8.6 mm, respectively. System 1, with a locking mechanism, showed the least displacement at the end of the test. Conclusion: A few PPS systems showed better results in terms on stiffness and life than the open system. The experiments showed that mechanical strength varies depending on the spinal implant. The experiments conducted are essential and significant to provide the mechanical strength required for surgical reconstruction. en-copyright= kn-copyright= en-aut-name=OdaYoshiaki en-aut-sei=Oda en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakigawaTomoyuki en-aut-sei=Takigawa en-aut-mei=Tomoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ItoYasuo en-aut-sei=Ito en-aut-mei=Yasuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MisawaHaruo en-aut-sei=Misawa en-aut-mei=Haruo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TetsunagaTomoko en-aut-sei=Tetsunaga en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UotaniKoji en-aut-sei=Uotani en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Orthopaedic Surgery, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Orthopaedic Surgery, Kobe Red Cross Hospital kn-affil= affil-num=3 en-affil=Department of Orthopaedic Surgery, Kobe Red Cross Hospital kn-affil= affil-num=4 en-affil=Department of Orthopaedic Surgery, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Orthopaedic Surgery, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Orthopaedic Surgery, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Orthopaedic Surgery, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University kn-affil= en-keyword=spine surgery kn-keyword=spine surgery en-keyword=percutaneous pedicle screw kn-keyword=percutaneous pedicle screw en-keyword=percutaneous systems kn-keyword=percutaneous systems en-keyword=break test kn-keyword=break test en-keyword=fatigue test kn-keyword=fatigue test en-keyword=biomechanical study discipline kn-keyword=biomechanical study discipline END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=3 article-no= start-page=297 end-page=305 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evaluation of Fast Diffusion Kurtosis Imaging Using New Software Designed for Widespread Clinical Use en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical research using restricted diffusion-weighted imaging, especially diffusion kurtosis (DK) imaging, has been progressing, with reports on its effectiveness in the diagnostic imaging of cerebral infarctions, neurodegenerative diseases, and tumors, among others. However, the application of DK imaging in daily clinical practice has not spread because of the long imaging time required and the use of specific software for image creation. Herein, with the aim of promoting clinical research using DK imaging at any medical facility, we evaluated fast DK imaging using a new software program. We developed a new macro program that produces DK images using general-purpose, inexpensive software (Microsoft Excel and ImageJ), and we evaluated fast DK imaging using bio-phantoms and a healthy volunteer in clinical trials. The DK images created by the new software with diffusion-weighted images captured with short-time imaging sequences were similar to the original DK images captured with long-time imaging sequences. The DK images using three b-values, which can reduce the imaging time by 43%, were equivalent to the DK images using five b-values. The DK imaging technique developed herein might allow any medical facility to increase its daily clinical use of DK imaging and easily conduct clinical research. en-copyright= kn-copyright= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KonishiKohei en-aut-sei=Konishi en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SugimotoKohei en-aut-sei=Sugimoto en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshimuraYuuki en-aut-sei=Yoshimura en-aut-mei=Yuuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HamadaKentaro en-aut-sei=Hamada en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KhasawnehcAbdullah en-aut-sei=Khasawnehc en-aut-mei=Abdullah kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=BarhamMajd en-aut-sei=Barham en-aut-mei=Majd kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TekikiNouha en-aut-sei=Tekiki en-aut-mei=Nouha kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SugiantoIrfan en-aut-sei=Sugianto en-aut-mei=Irfan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=BamgboseBabatunde O. en-aut-sei=Bamgbose en-aut-mei=Babatunde O. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IshizakaHinata en-aut-sei=Ishizaka en-aut-mei=Hinata kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=ShimizuYudai en-aut-sei=Shimizu en-aut-mei=Yudai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NakamitsuYuki en-aut-sei=Nakamitsu en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=Al-HammadWlla E. en-aut-sei=Al-Hammad en-aut-mei=Wlla E. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=KamizakiRyo en-aut-sei=Kamizaki en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=KurozumiAkira en-aut-sei=Kurozumi en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=MatsushitaToshi en-aut-sei=Matsushita en-aut-mei=Toshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=OhnoSeiichiro en-aut-sei=Ohno en-aut-mei=Seiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=AsaumiJunichi en-aut-sei=Asaumi en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= affil-num=1 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=5 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=16 en-affil=Central Division of Radiology, Okayama University Hospital kn-affil= affil-num=17 en-affil=Central Division of Radiology, Okayama University Hospital kn-affil= affil-num=18 en-affil=Central Division of Radiology, Okayama University Hospital kn-affil= affil-num=19 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=20 en-affil=Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=fast diffusion kurtosis imaging kn-keyword=fast diffusion kurtosis imaging en-keyword=mean kurtosis kn-keyword=mean kurtosis en-keyword=restricted diffusion kn-keyword=restricted diffusion en-keyword=Excel kn-keyword=Excel en-keyword=ImageJ kn-keyword=ImageJ END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=26 article-no= start-page=77 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=1999 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=戦争捕虜問題の比較文化的考察：「食」の問題を中心に(下) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakaoTomoyo en-aut-sei=Nakao en-aut-mei=Tomoyo kn-aut-name=中尾知代 kn-aut-sei=中尾 kn-aut-mei=知代 aut-affil-num=1 ORCID= affil-num=1 en-affil=Okayama University kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=23 article-no= start-page=27 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=1999 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=戦争捕虜問題の比較文化的考察：「食」の問題を中心に(中) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakaoTomoyo en-aut-sei=Nakao en-aut-mei=Tomoyo kn-aut-name=中尾知代 kn-aut-sei=中尾 kn-aut-mei=知代 aut-affil-num=1 ORCID= affil-num=1 en-affil=Okayama University kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=22 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=1998 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=戦争捕虜問題の比較文化的考察：「食」の問題を中心に(上) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakaoTomoyo en-aut-sei=Nakao en-aut-mei=Tomoyo kn-aut-name=中尾知代 kn-aut-sei=中尾 kn-aut-mei=知代 aut-affil-num=1 ORCID= affil-num=1 en-affil=Okayama University kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=1 article-no= start-page=93 end-page=98 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cystic Intracranial Recurrence of Olfactory Neuroblastoma without Accumulation on Fluorine-18-fluorodeoxyglucose Positron Emission Tomography en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 66-year-old man underwent multimodal treatment for olfactory neuroblastoma (ONB). When he was 72 years old, a cystic intracranial lesion without accumulation on fluorine-18-fluorodeoxyglucose positron emission tomography was detected. Surgical resection was performed when the patient was 73 years old. The pathological examination revealed recurrence of ONB, and the patient underwent focal irradiation. At age 81, he presented with a second recurrence in the right occipital lobe with radiological and pathological findings similar to the prior recurrence. This case suggests that pathological confirmation should be considered in cases with atypical radiological findings following the treatment of ONB. en-copyright= kn-copyright= en-aut-name=IshiYukitomo en-aut-sei=Ishi en-aut-mei=Yukitomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamaguchiShigeru en-aut-sei=Yamaguchi en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HatanakaKanako C. en-aut-sei=Hatanaka en-aut-mei=Kanako C. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakakuwaEmi en-aut-sei=Takakuwa en-aut-mei=Emi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MotegiHiroaki en-aut-sei=Motegi en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HondaTaishi en-aut-sei=Honda en-aut-mei=Taishi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KobayashiHiroyuki en-aut-sei=Kobayashi en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TerasakaShunsuke en-aut-sei=Terasaka en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HommaAkihiro en-aut-sei=Homma en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=FujimuraMiki en-aut-sei=Fujimura en-aut-mei=Miki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=HoukinKiyohiro en-aut-sei=Houkin en-aut-mei=Kiyohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University kn-affil= affil-num=2 en-affil=Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University kn-affil= affil-num=3 en-affil=Department of Surgical Pathology, Hokkaido University Hospital kn-affil= affil-num=4 en-affil=Department of Surgical Pathology, Hokkaido University Hospital kn-affil= affil-num=5 en-affil=Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University kn-affil= affil-num=6 en-affil=Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University kn-affil= affil-num=7 en-affil=Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University kn-affil= affil-num=8 en-affil=Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University kn-affil= affil-num=9 en-affil=Department of Otolaryngology-Head & Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University kn-affil= affil-num=10 en-affil=Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University kn-affil= affil-num=11 en-affil=Department of Neurosurgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University kn-affil= en-keyword=cystic recurrence kn-keyword=cystic recurrence en-keyword=esthesioneuroblastoma kn-keyword=esthesioneuroblastoma en-keyword=fluorine-18-fluorodeoxyglucose positron emission tomography kn-keyword=fluorine-18-fluorodeoxyglucose positron emission tomography en-keyword=intracranial recurrence kn-keyword=intracranial recurrence en-keyword=olfactory neuroblastoma kn-keyword=olfactory neuroblastoma END start-ver=1.4 cd-journal=joma no-vol=12835 cd-vols= no-issue= article-no= start-page=64 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210827 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=(Short Paper) Evidence Collection and Preservation System with Virtual Machine Monitoring en-subtitle= kn-subtitle= en-abstract= kn-abstract=In a system audit and verification, it is important to securely collect and preserve evidence of execution environments, execution processes, and program execution results. Evidence-based verification of program processes ensures their authenticity; for example, the processes include no altered/infected program library. This paper proposes a solution for collection of evidence on program libraries based on Virtual Machine Monitor (VMM). The solution can solve semantic gap by obtaining library file path names. This paper also shows a way to obtain hash values of library files from a guest OS. Furthermore, this paper provides examples of evidence on program xecution and the overhead of the solution. en-copyright= kn-copyright= en-aut-name=NakamuraToru en-aut-sei=Nakamura en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ItoHiroshi en-aut-sei=Ito en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KiyomotoShinsaku en-aut-sei=Kiyomoto en-aut-mei=Shinsaku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamauchiToshihiro en-aut-sei=Yamauchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=KDDI Research, Inc. kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=KDDI Research, Inc. kn-affil= affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Virtual machine introspection kn-keyword=Virtual machine introspection en-keyword=Forensics kn-keyword=Forensics en-keyword=OS security kn-keyword=OS security END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue= article-no= start-page=111651 end-page=111665 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=2021 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mitigation of Kernel Memory Corruption Using Multiple Kernel Memory Mechanism en-subtitle= kn-subtitle= en-abstract= kn-abstract=Operating systems adopt kernel protection methods (e.g., mandatory access control, kernel address space layout randomization, control flow integrity, and kernel page table isolation) as essential countermeasures to reduce the likelihood of kernel vulnerability attacks. However, kernel memory corruption can still occur via the execution of malicious kernel code at the kernel layer. This is because the vulnerable kernel code and the attack target kernel code or kernel data are located in the same kernel address space. To gain complete control of a host, adversaries focus on kernel code invocations, such as function pointers that rely on the starting points of the kernel protection methods. To mitigate such subversion attacks, this paper presents multiple kernel memory (MKM), which employs an alternative design for kernel address space separation. The MKM mechanism focuses on the isolation granularity of the kernel address space during each execution of the kernel code. MKM provides two kernel address spaces, namely, i) the trampoline kernel address space, which acts as the gateway feature between user and kernel modes and ii) the security kernel address space, which utilizes the localization of the kernel protection methods (i.e., kernel observation). Additionally, MKM achieves the encapsulation of the vulnerable kernel code to prevent access to the kernel code invocations of the separated kernel address space. The evaluation results demonstrated that MKM can protect the kernel code and kernel data from a proof-of-concept kernel vulnerability that could lead to kernel memory corruption. In addition, the performance results of MKM indicate that the system call overhead latency ranges from 0.020 μs to 0.5445 μs, while the web application benchmark ranges from 196.27 μs to 6, 685.73 μs for each download access of 100,000 Hypertext Transfer Protocol sessions. MKM attained a 97.65% system benchmark score and a 99.76% kernel compilation time. en-copyright= kn-copyright= en-aut-name=KuzunoHiroki en-aut-sei=Kuzuno en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamauchiToshihiro en-aut-sei=Yamauchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=1Intelligent Systems Laboratory, SECOM Company Ltd. kn-affil= affil-num=2 en-affil=2Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Memory corruption kn-keyword=Memory corruption en-keyword=kernel vulnerability kn-keyword=kernel vulnerability en-keyword=system security kn-keyword=system security en-keyword=operating system kn-keyword=operating system END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=6 article-no= start-page=510 end-page=512 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Treatment of Bucco-Accessory Root Canal of a Maxillary Incisor with a Combination of Cone Beam Computed Tomography and Continuous Supersonic Wave Condensation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective: A novel treatment for bucco-accessory root canal (bARC), which is difficult to treat by regular endodontic therapy, is discussed.
Clinical Presentation and Intervention: A bARC in the maxillary right incisor with symptomatic irreversible pulpitis was detected using cone beam computed tomography (CBCT) after conventional dental radiography. The pulp was extirpated and the canal enlarged using rotary files and chemo-mechanical reagents. The main root canal and bARC were obturated with thermoplastic gutta-percha using continuous wave condensation. Postoperative CBCT revealed a completely treated bARC.
Conclusion: A combination of CBCT and continuous wave condensation is ideal for bARCs in incisors. en-copyright= kn-copyright= en-aut-name=AriasZulema en-aut-sei=Arias en-aut-mei=Zulema kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=CazasIvana en-aut-sei=Cazas en-aut-mei=Ivana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Yasir Dilshad Siddiqui kn-aut-sei=Yasir Dilshad Siddiqui kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamashiroKeisuke en-aut-sei=Yamashiro en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakashibaShogo en-aut-sei=Takashiba en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=Mohammad Khursheed Alam en-aut-sei=Mohammad Khursheed Alam en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Faculty of Dentistry, University Mayor of San Andres kn-affil= affil-num=2 en-affil=Private Dental Office kn-affil= affil-num=3 en-affil=Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=College of Dentistry, Jouf University kn-affil= en-keyword=maxillary incisor kn-keyword=maxillary incisor en-keyword=bucco-accessory root canal kn-keyword=bucco-accessory root canal en-keyword=cone beam computed tomography kn-keyword=cone beam computed tomography en-keyword=continuous supersonic wave condensation kn-keyword=continuous supersonic wave condensation END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=6 article-no= start-page=741 end-page=744 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Sublingual Gland Carcinoma Revealed by Choroidal Metastasis en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 65-year-old man presented with a 1-week history of left eye distortion. An elevated choroidal lesion covering 6 disc diameters was found in the posterior retina of the left eye. Systemic examination revealed sublingual gland carcinoma and multiple lung metastases, and the diagnosis was choroidal metastasis from sublingual gland carcinoma. Following chemotherapy and radiation therapy, the choroidal lesion shrunk and the patient’s visual acuity improved. The patient died 23 months after his first visit. To the best of our knowledge, this is the first reported case of choroidal metastasis from sublingual gland carcinoma. en-copyright= kn-copyright= en-aut-name=MoritaTetsuro en-aut-sei=Morita en-aut-mei=Tetsuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShiodeYusuke en-aut-sei=Shiode en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KimuraShuhei en-aut-sei=Kimura en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HosokawaMio en-aut-sei=Hosokawa en-aut-mei=Mio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=DoiShinichiro en-aut-sei=Doi en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakahashiKosuke en-aut-sei=Takahashi en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatobaRyo en-aut-sei=Matoba en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KanzakiYuki en-aut-sei=Kanzaki en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TabataMasahiro en-aut-sei=Tabata en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MorizaneYuki en-aut-sei=Morizane en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Center for Clinical Oncology, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=adenoid cystic carcinoma kn-keyword=adenoid cystic carcinoma en-keyword=choroidal metastasis kn-keyword=choroidal metastasis en-keyword=sublingual gland kn-keyword=sublingual gland END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=6 article-no= start-page=699 end-page=704 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Guideline-based Treatment of Glucocorticoid-induced Osteoporosis in Patients with Rheumatoid Arthritis: A Retrospective Study with the AORA Registry en-subtitle= kn-subtitle= en-abstract= kn-abstract=Glucocorticoid-induced osteoporosis (GIOP) is one of the side effects associated with glucocorticoid (GC) therapy. In 2014, the Japanese Society for Bone and Mineral Research (JSBMR) provided new guidelines for the management and treatment of GIOP. The aim of the present study was to clarify the prevalence of patients with rheumatoid arthritis (RA) requiring treatment according to the new guidelines and to identify risk factors associated with lack of treatment in these patients. Patients in the 2018 Akita Orthopedic group on Rheumatoid Arthritis (AORA) database were enrolled. Of 2,234 patients with RA in the database, 683 (30.6%) met the 2014 JSBMR guideline treatment criteria, and 480 (70.3%) had been treated. The untreated group included a larger number of males, younger patients, and patients treated in clinics rather than hospital (p<0.001, p=0.015, and p<0.001, respectively). Multivariate analyses found that male sex, younger age, and clinic-based RA care were significant risk factors associated with lack of treatment (p<0.001, p=0.013, and p<0.001, respectively). Thus, male sex, younger age, and clinic-based care were identified as risk factors en-copyright= kn-copyright= en-aut-name=KawanoTetsuya en-aut-sei=Kawano en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyakoshiNaohisa en-aut-sei=Miyakoshi en-aut-mei=Naohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsuchieHiroyuki en-aut-sei=Tsuchie en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KashiwaguraTakeshi en-aut-sei=Kashiwagura en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KobayashiMoto en-aut-sei=Kobayashi en-aut-mei=Moto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AonumaHiroshi en-aut-sei=Aonuma en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SugimuraYusuke en-aut-sei=Sugimura en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShimadaYoichi en-aut-sei=Shimada en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine kn-affil= affil-num=2 en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of Orthopedic Surgery, Akita City Hospital kn-affil= affil-num=5 en-affil=Department of Orthopedic Surgery, Hiraka General Hospital Yokote City kn-affil= affil-num=6 en-affil=Department of Orthopedic Surgery, Ogachi Central Hospital Yuzawa City kn-affil= affil-num=7 en-affil=Department of Orthopedic Surgery, Nakadori General Hospital Akita City kn-affil= affil-num=8 en-affil=Department of Orthopedic Surgery, Akita University Graduate School of Medicine kn-affil= en-keyword=glucocorticoid kn-keyword=glucocorticoid en-keyword=glucocorticoid-induced osteoporosis kn-keyword=glucocorticoid-induced osteoporosis en-keyword=rheumatoid arthritis kn-keyword=rheumatoid arthritis en-keyword=osteoporosis kn-keyword=osteoporosis en-keyword=osteopenia kn-keyword=osteopenia END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=5 article-no= start-page=611 end-page=623 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Relation Between Identity Disclosure to Family Members and Mental Health in Japanese Transgender People en-subtitle= kn-subtitle= en-abstract= kn-abstract=Family members are critical mediators of the experiences of transgender people. We studied whether transgen-der subjects had disclosed their identity to their families and their families’ reactions after the disclosure. We also evaluated the subjects’ mental state and its association with disclosure status. Transgender people were recruited for this anonymous questionnaire survey in the Okayama University Hospital gender clinic. Subjects disclosed their identity to family members at the following rates: 68.7% to the father, 89.1% to the mother, 59.1% to a brother, 77.8% to a sister, and 47.6% to grandparents. Fathers had the lowest rate (26.7%) of posi-tive reactions, while over 50% of fathers showed an ambiguous response. Approximately 20% of parents showed a negative response. The majority of parents agreed to hormonal treatment and sex-reassignment sur-gery and that the transgender child should live with the gender they wanted to express. However, the rate of subjects with mood and anxiety disorders according to the Kessler 6 scale was significantly higher in those who experienced negative or ambiguous reactions from family members compared to those who experienced posi-tive reactions. Educational and mental health professionals should support the disclosure process of transgen-der people as well as their family members. en-copyright= kn-copyright= en-aut-name=ZhouYu en-aut-sei=Zhou en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FurutaniMichiyo en-aut-sei=Furutani en-aut-mei=Michiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AthurupanaRukmali en-aut-sei=Athurupana en-aut-mei=Rukmali kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakatsukaMikiya en-aut-sei=Nakatsuka en-aut-mei=Mikiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= en-keyword=disclosure kn-keyword=disclosure en-keyword=family functioning kn-keyword=family functioning en-keyword=gender nonconformity kn-keyword=gender nonconformity en-keyword=mental health kn-keyword=mental health en-keyword=transgender kn-keyword=transgender END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=5 article-no= start-page=601 end-page=609 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Effect of Peer Instruction Lectures on Learning Attitudes in Epidemiology Education en-subtitle= kn-subtitle= en-abstract= kn-abstract=Research suggests that the fundamental concepts of epidemiology cannot be sufficiently learned in traditional lectures, and interactive learning is necessary. However, few studies have investigated interactive epidemiology education in general, or peer instruction (PI) in particular. This study investigated the effect of PI. Study par-ticipants were fourth-year medical students. The attitude of participants in regard to PI learning was examined in a non-PI and a PI group. The Survey of Attitudes Toward Statistics (SATS) (containing six sub-categories) was conducted as a learning-attitudes index. The pre- and post-lecture scores were compared between the non-PI and PI groups using double robust (DR) estimation. The non-PI and PI groups consisted of 20 and 121 student participants, respectively. In DR estimation, affect exhibited the lowest SATS score changes, at −0.51 (95% confidence interval −0.78 to −0.24; p-value < 0.001), whereas effort exhibited the highest score changes of 0.01 (95% confidence interval −0.30 to 0.32; p-value = 0.952). The epidemiology lecture with PI did not increase the SATS scores. This might be due to issues related to the experimental design. Further research investigating the effects of interactive epidemiology education, it will be necessary to develop tools for assessing the learning of epidemiological concepts and to improve the research design. en-copyright= kn-copyright= en-aut-name=MitsuhashiToshiharu en-aut-sei=Mitsuhashi en-aut-mei=Toshiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= en-keyword=medical students kn-keyword=medical students en-keyword=peer instruction kn-keyword=peer instruction en-keyword=epidemiological education kn-keyword=epidemiological education en-keyword=learning attitude kn-keyword=learning attitude en-keyword=double robust esti-mation kn-keyword=double robust esti-mation END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=5 article-no= start-page=557 end-page=565 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Relationship between Pressure Ulcers in Elderly People and Physiological Indices of the Skin en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study examined the relationship between skin physiological indices and pressure ulcers in elderly people. The subjects were 55 bedridden elderly Japanese patients with a median age of 85 years. The following parame-ters were measured using non-invasive devices: skin surface temperature, moisture content in the stratum corneum, moisture content in the dermis, transepidermal water loss as an index of skin barrier function, skin erythema and skin elasticity. The sacral and 2 heel areas were observed as sites predisposed to pressure ulcers. Within one month after measuring the skin physiological indices, we confirmed pressure ulcers of National Pressure Ulcer Advisory Panel classification Stage II or worse based on medical records. Among the 55 patients, 4 (7.3%) prospectively developed a total of 5 pressure ulcers within 16 days. Only the skin erythema score was significantly higher with than without pressure ulcers (p < 0.001). We performed a binary logistic regression analysis and confirmed a significant relationship between pressure-ulcer development and the level of erythema (odds ratio = 1.026; 95% confidence interval: 1.011-1.042). Skin erythema increased before the development of pressure ulcers. Taken together, our results show that the high skin erythema score can be a predictive indicator of pressure ulcers. en-copyright= kn-copyright= en-aut-name=Takeshima KoharaHiroko en-aut-sei=Takeshima Kohara en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaMitsunori en-aut-sei=Ikeda en-aut-mei=Mitsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkawaMasami en-aut-sei=Okawa en-aut-mei=Masami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Nursing, University of Kochi kn-affil= affil-num=2 en-affil=Department of Nursing, University of Kochi kn-affil= affil-num=3 en-affil=Shiragikuen Hospital kn-affil= en-keyword=elderly people kn-keyword=elderly people en-keyword=erythema kn-keyword=erythema en-keyword=pressure ulcer kn-keyword=pressure ulcer en-keyword=skin kn-keyword=skin END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=913 end-page=915 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=2021 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Analysis of commands of Telnet logs illegally connected to IoT devices en-subtitle= kn-subtitle= en-abstract= kn-abstract=Mirai is an active malware that targets and poses constant threats to IoT devices. IoT malware penetrates IoT devices illegally, makes them download other malware such as bots, and infects them. Therefore, to improve the security of IoT devices, it is important to analyze the behaviors of IoT malware and take countermeasures. In this study, to analyze the behaviors of IoT malware after entering IoT devices and propose new security functions for operating systems to prevent activities such as IoT malware infection, we analyze Telnet logs collected by a honeypot of IoT devices. Thereafter, we report the analysis results regarding IoT malware input commands. The results show that many commands related to shell execution, file download, changing file permissions, and file transfer, are often executed by IoT malware. en-copyright= kn-copyright= en-aut-name=YamauchiToshihiro en-aut-sei=Yamauchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshimotoRyota en-aut-sei=Yoshimoto en-aut-mei=Ryota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=BabaTakahiro en-aut-sei=Baba en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshiokaKatsunari en-aut-sei=Yoshioka en-aut-mei=Katsunari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environment and Information Sciences / Institute of Advanced Sciences Yokohama National University kn-affil= en-keyword=IoT kn-keyword=IoT en-keyword=malware kn-keyword=malware en-keyword=Telnet log kn-keyword=Telnet log END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3 article-no= start-page=279 end-page=287 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202106 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of Gram-negative Rod Blood Stream Infection on Acute GVHD in Allogeneic Hematopoietic Stem Cell Transplantation: A Single-institute Analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=A bloodstream infection (BSI) is the most common serious infectious complication of hematopoietic stem cell transplantation (HSCT). BSI promotes an inflammatory state, which exacerbates acute graft-versus-host disease (GVHD). We investigated whether a Gram-negative rod bloodstream infection (GNR-BSI), which develops early after allo-HSCT, affected the onset or exacerbated acute GVHD in 465 patients who underwent allo-HSCT from 1995 through 2015 at a single institution. Eighty-eight patients (19%) developed BSI during the study period. Among the cultures, 50 (57%) were Gram-positive cocci (GPC) and 31 (35%) were GNR. Of the 465 patients, 187 (40%) developed acute GVHD of grade II or higher within the first 100 days post-allogeneic HSCT: 124 (27%) had acute GVHD grade II, 47 (10%) had grade III, and 16 (3%) had grade IV. Multivariate analysis revealed that GNR-BSI was a significant risk factor for grade II-IV acute GVHD (grade II-IV: hazard ratio [HR] 1.75, 95% confidence interval [CI] 1.03-2.97; grade III-IV: HR 2.37, 95% CI 1.03-5.43). These results suggest that GNR-BSI may predict the onset and exacerbation of acute GVHD. en-copyright= kn-copyright= en-aut-name=NishinoharaMasa-aki en-aut-sei=Nishinohara en-aut-mei=Masa-aki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishimoriHisakazu en-aut-sei=Nishimori en-aut-mei=Hisakazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiwaraHideaki en-aut-sei=Fujiwara en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AsadaNoboru en-aut-sei=Asada en-aut-mei=Noboru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=EnnishiDaisuke en-aut-sei=Ennishi en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsuokaKen-ichi en-aut-sei=Matsuoka en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FujiiKeiko en-aut-sei=Fujii en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FujiiNobuharu en-aut-sei=Fujii en-aut-mei=Nobuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=blood stream infection kn-keyword=blood stream infection en-keyword=graft-versus-host disease kn-keyword=graft-versus-host disease en-keyword=gram negative rods kn-keyword=gram negative rods END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3 article-no= start-page=261 end-page=268 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202106 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Dental Treatment for Special Needs Patients Under General Anaesthesia: A 14-year Experience from South Bosnia and Herzegovina en-subtitle= kn-subtitle= en-abstract= kn-abstract=We conducted a retrospective analysis of records of special needs patients (SNPs) who received dental treatment under orotracheal-intubation general anaesthesia (OIGA) at Caritas Centre St. Family in Mostar, Bosnia and Herzegovina during the 14-year period from January 2005 to December 2018. Of the 7,085 SNPs who received dental treatment, 1,220 (17.2%) received dental treatment under OIGA: 829 (67.9%) males and 391 (32.1%) females. The patients’ mean age was 18.3±10.9 years (747 paediatric and 473 adult patients). Mental retardation and psychiatric problems were the most common medical conditions (81.22%). The most common indication for dental treatment under OIGA was behaviour management (87.21%), and 81% of the patients had an urgent need for treatment. Many of the patients had restorative treatment (3,833) and tooth extractions (3,681). From 2011 onwards, the number of tooth extractions decreased significantly. Annual trends revealed a rapid increase of patients every year. The mean dental treatment duration was 95.3±12.1 min; the mean time under OIGA was 98±8.5 min. No serious adverse effects occurred. There was increase of annual trend of SNP in OIGA. The number of extractions decreased while the number of preventive and restorative dental treatments increased. en-copyright= kn-copyright= en-aut-name=ArapovicLidija Lasic en-aut-sei=Arapovic en-aut-mei=Lidija Lasic kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KarlovicZoran en-aut-sei=Karlovic en-aut-mei=Zoran kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=BrzovicValentina Rajic en-aut-sei=Brzovic en-aut-mei=Valentina Rajic kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=BukvicAmer en-aut-sei=Bukvic en-aut-mei=Amer kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=CoricAnka en-aut-sei=Coric en-aut-mei=Anka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=VukojevicKatarina en-aut-sei=Vukojevic en-aut-mei=Katarina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=VerzakZeljko en-aut-sei=Verzak en-aut-mei=Zeljko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Health Care Center Mostar, University of Mostar kn-affil= affil-num=2 en-affil=School of Medicine, University of Mostar kn-affil= affil-num=3 en-affil=School of Medicine, University of Mostar kn-affil= affil-num=4 en-affil=Primary Health Care Center Novi Travnik kn-affil= affil-num=5 en-affil=Health Care Center Mostar, University of Mostar kn-affil= affil-num=6 en-affil=School of Medicine, University of Mostar kn-affil= affil-num=7 en-affil=School of Medicine, University of Mostar kn-affil= en-keyword=special needs patients kn-keyword=special needs patients en-keyword=general anaesthesia kn-keyword=general anaesthesia en-keyword=dental treatment kn-keyword=dental treatment en-keyword= dental care kn-keyword= dental care en-keyword=mental retardation kn-keyword=mental retardation END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=2 article-no= start-page=255 end-page=259 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=An Unusual Case of Drunk Driving in Japan: Alcohol-Related Sleepwalking en-subtitle= kn-subtitle= en-abstract= kn-abstract=Alcohol has been identified as a potential precipitating factor for parasomnia, particularly sleepwalking (SW). We report an unusual case of a Japanese drunk driver who may have experienced alcohol-related SW, based on the statements of the suspect, pharmacokinetic analyses of the suspect’s breath alcohol concentration, testimonies of witnesses, driving recorder data, and medical records. The existence of sleep-related criminal acts performed while a suspect experiences memory loss under the influence of alcohol has not been sufficiently recognized, and awareness of such acts should be raised among the police, public prosecutors, and the general public in Japan. en-copyright= kn-copyright= en-aut-name= Himemiya-HakuchoAyako en-aut-sei= Himemiya-Hakucho en-aut-mei=Ayako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujimiyaTatsuya en-aut-sei=Fujimiya en-aut-mei=Tatsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Legal Medicine, Yamaguchi University Graduate School of Medicine kn-affil= affil-num=2 en-affil=Department of Medical Education, Yamaguchi University Graduate School of Medicine kn-affil= en-keyword=drunk driving kn-keyword=drunk driving en-keyword=sleepwalking kn-keyword=sleepwalking en-keyword=parasomnia kn-keyword=parasomnia en-keyword=amnesia kn-keyword=amnesia en-keyword=blood alcohol concentration kn-keyword=blood alcohol concentration END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=2 article-no= start-page=249 end-page=253 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Endogenous Bacterial Endophthalmitis Caused by Iliopsoas Abscess en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 79-year-old woman presented to our hospital with a 10-day history of gradually worsening binocular vision and severe backache. Further investigations revealed poor bilateral best-corrected visual acuities (BCVA), bilateral vitreous opacities, gray-white lesions scattered throughout the retina, and a left iliopsoas abscess on CT that later grew out methicillin-sensitive S. aureus. The abscess was drained and intravenous antibiotics were initiated, but the left eye additionally required intravitreal vancomycin. BCVA for both eyes normalized within 1 year. Intramuscular abscess should be considered as a possible primary lesion in cases of endogenous bacterial endophthalmitis. en-copyright= kn-copyright= en-aut-name=SunWeiying en-aut-sei=Sun en-aut-mei=Weiying kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShiodeYusuke en-aut-sei=Shiode en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TokumasuKazuki en-aut-sei=Tokumasu en-aut-mei=Kazuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KimuraShuhei en-aut-sei=Kimura en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HosokawaMio en-aut-sei=Hosokawa en-aut-mei=Mio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=DoiShinichiro en-aut-sei=Doi en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakahashiKosuke en-aut-sei=Takahashi en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MatobaRyo en-aut-sei=Matoba en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MorizaneYuki en-aut-sei=Morizane en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=endogenous bacterial endophthalmitis kn-keyword=endogenous bacterial endophthalmitis en-keyword=methicillin-sensitive Staphylococcus aureus kn-keyword=methicillin-sensitive Staphylococcus aureus en-keyword=iliopsoas abscess kn-keyword=iliopsoas abscess en-keyword=intravitreal injection kn-keyword=intravitreal injection en-keyword=vancomycin kn-keyword=vancomycin END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=2 article-no= start-page=153 end-page=167 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Lactoferrin-like Immunoreactivity in Distinct Neuronal Populations in the Mouse Central Nervous System en-subtitle= kn-subtitle= en-abstract= kn-abstract=Lactoferrin (Lf) is an iron-binding glycoprotein mainly found in exocrine secretions and the secondary granules of neutrophils. In the central nervous system (CNS), expression of the Lf protein has been reported in the lesions of some neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, as well as in the aged brain. Lf is primarily considered an iron chelator, protecting cells from potentially toxic iron or iron-requiring microorganisms. Other biological functions of Lf include immunomodulation and transcriptional regulation. However, the roles of Lf in the CNS have yet to be fully clarified. In this study, we raised an antiserum against mouse Lf and investigated the immunohistochemical localization of Lf-like immunoreactivity (Lf-LI) throughout the CNS of adult mice. Lf-LI was found in some neuronal populations throughout the CNS. Intense labeling was found in neurons in the olfactory systems, hypothalamic nuclei, entorhinal cortex, and a variety of brainstem nuclei. This study provides detailed information on the Lf-LI distribution in the CNS, and the findings should promote further understanding of both the physiological and pathological significance of Lf in the CNS. en-copyright= kn-copyright= en-aut-name=ShimaokaShigeyoshi en-aut-sei=Shimaoka en-aut-mei=Shigeyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HamaokaHitomi en-aut-sei=Hamaoka en-aut-mei=Hitomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InoueJunji en-aut-sei=Inoue en-aut-mei=Junji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AsanumaMasato en-aut-sei=Asanuma en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TooyamaIkuo en-aut-sei=Tooyama en-aut-mei=Ikuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KondoYoichi en-aut-sei=Kondo en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical and Pharmaceutical University kn-affil= affil-num=2 en-affil=Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical and Pharmaceutical University kn-affil= affil-num=3 en-affil=Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical and Pharmaceutical University kn-affil= affil-num=4 en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Molecular Neuroscience Research Center, Shiga University of Medical Science kn-affil= affil-num=6 en-affil=Molecular Neuroscience Research Center, Shiga University of Medical Science kn-affil= en-keyword=lactoferrin kn-keyword=lactoferrin en-keyword=immunohistochemistry kn-keyword=immunohistochemistry en-keyword=brain mapping kn-keyword=brain mapping END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=1 article-no= start-page=10 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210216 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Antenna arrangement and energy-transfer pathways of PSI-LHCI from the moss Physcomitrella patens en-subtitle= kn-subtitle= en-abstract= kn-abstract=Plants harvest light energy utilized for photosynthesis by light-harvesting complex I and II (LHCI and LHCII) surrounding photosystem I and II (PSI and PSII), respectively. During the evolution of green plants, moss is at an evolutionarily intermediate position from aquatic photosynthetic organisms to land plants, being the first photosynthetic organisms that landed. Here, we report the structure of the PSI-LHCI supercomplex from the moss Physcomitrella patens (Pp) at 3.23 angstrom resolution solved by cryo-electron microscopy. Our structure revealed that four Lhca subunits are associated with the PSI core in an order of Lhca1-Lhca5-Lhca2-Lhca3. This number is much decreased from 8 to 10, the number of subunits in most green algal PSI-LHCI, but the same as those of land plants. Although Pp PSI-LHCI has a similar structure as PSI-LHCI of land plants, it has Lhca5, instead of Lhca4, in the second position of Lhca, and several differences were found in the arrangement of chlorophylls among green algal, moss, and land plant PSI-LHCI. One chlorophyll, PsaF-Chl 305, which is found in the moss PSI-LHCI, is located at the gap region between the two middle Lhca subunits and the PSI core, and therefore may make the excitation energy transfer from LHCI to the core more efficient than that of land plants. On the other hand, energy-transfer paths at the two side Lhca subunits are relatively conserved. These results provide a structural basis for unravelling the mechanisms of light-energy harvesting and transfer in the moss PSI-LHCI, as well as important clues on the changes of PSI-LHCI after landing. en-copyright= kn-copyright= en-aut-name=YanQiujing en-aut-sei=Yan en-aut-mei=Qiujing kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ZhaoLiang en-aut-sei=Zhao en-aut-mei=Liang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WangWenda en-aut-sei=Wang en-aut-mei=Wenda kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=PiXiong en-aut-sei=Pi en-aut-mei=Xiong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HanGuangye en-aut-sei=Han en-aut-mei=Guangye kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WangJie en-aut-sei=Wang en-aut-mei=Jie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ChengLingpeng en-aut-sei=Cheng en-aut-mei=Lingpeng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HeYi-Kun en-aut-sei=He en-aut-mei=Yi-Kun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KuangTingyun en-aut-sei=Kuang en-aut-mei=Tingyun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=QinXiaochun en-aut-sei=Qin en-aut-mei=Xiaochun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SuiSen-Fang en-aut-sei=Sui en-aut-mei=Sen-Fang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=ShenJian-Ren en-aut-sei=Shen en-aut-mei=Jian-Ren kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences kn-affil= affil-num=2 en-affil=State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University kn-affil= affil-num=3 en-affil=Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences kn-affil= affil-num=4 en-affil=State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University kn-affil= affil-num=5 en-affil=Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences kn-affil= affil-num=6 en-affil=Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences kn-affil= affil-num=7 en-affil=State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University kn-affil= affil-num=8 en-affil=College of Life Sciences, Department of Chemistry, Capital Normal University, kn-affil= affil-num=9 en-affil=Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences kn-affil= affil-num=10 en-affil=School of Biological Science and Technology, University of Jinan kn-affil= affil-num=11 en-affil=State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University kn-affil= affil-num=12 en-affil=Research Institute for Interdisciplinary Science, and Graduate School of Natural Science and Technology, Okayama University, kn-affil= END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=1 article-no= start-page=95 end-page=101 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202102 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Minimally Invasive Spinal Stabilization with Denosumab before Total Spondylectomy for a Collapsing Lower Lumbar Spinal Giant Cell Tumor en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 21-year-old man consulted our hospital for treatment of a spinal giant cell tumor (GCT) of Enneking stage III. Lower lumbar-spine tumors and severe spinal canal stenosis are associated with high risk for surgical mor-bidity. Stability was temporarily secured with a percutaneous pedicle screw fixation in combination with deno-sumab, which shrank the tumor. Total en bloc spondylectomy was then performed 6 months after initiation of denosumab, and the patient was followed for 3 years. There was no local recurrence, and bony fusion was obtained. Minimally invasive surgery and denosumab allowed safer and easier treatment of a collapsing lower lumbar extra-compartmental GCT. en-copyright= kn-copyright= en-aut-name=MinatoKeitaro en-aut-sei=Minato en-aut-mei=Keitaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HiranoToru en-aut-sei=Hirano en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KawashimaHiroyuki en-aut-sei=Kawashima en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamagishiTetsuro en-aut-sei=Yamagishi en-aut-mei=Tetsuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WatanabeKeigo en-aut-sei=Watanabe en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OhashiMasayuki en-aut-sei=Ohashi en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OgoseAkira en-aut-sei=Ogose en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=EndoNaoto en-aut-sei=Endo en-aut-mei=Naoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=2 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=3 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=4 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=5 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=6 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= affil-num=7 en-affil=Department of Orthopedic Surgery, Uonuma Kikan Hospital kn-affil= affil-num=8 en-affil=Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences kn-affil= en-keyword=spinal stabilization kn-keyword=spinal stabilization en-keyword=denosumab kn-keyword=denosumab en-keyword=spondylectomy kn-keyword=spondylectomy en-keyword=giant cell tumor kn-keyword=giant cell tumor END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue= article-no= start-page=554158 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20201126 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Postharvest Properties of Ultra-Late Maturing Peach Cultivars and Their Attributions to Melting Flesh (M) Locus: Re-evaluation of M Locus in Association With Flesh Texture en-subtitle= kn-subtitle= en-abstract= kn-abstract=The postharvest properties of two ultra-late maturing peach cultivars, "Tobihaku" (TH) and "Daijumitsuto" (DJ), were investigated. Fruit were harvested at commercial maturity and held at 25 degrees C. TH exhibited the characteristics of normal melting flesh (MF) peach, including rapid fruit softening associated with appropriate level of endogenous ethylene production In contrast, DJ did not soften at all during 3 weeks experimental period even though considerable ethylene production was observed. Fruit of TH and DJ were treated with 5,000 ppm of propylene, an ethylene analog, continuously for 7 days. TH softened rapidly whereas DJ maintained high flesh firmness in spite of an increase in endogenous ethylene production, suggesting that DJ but not TH lacked the ability to be softened in response to endogenous and exogenous ethylene/propylene. DNA-seq analysis showed that tandem endo-polygalacturonase (endoPG) genes located at melting flesh (M) locus, Pp-endoPGM (PGM), and Pp-endoPGF (PGF), were deleted in DJ. The endoPG genes at M locus are known to control flesh texture of peach fruit, and it was suggested that the non-softening property of DJ is due to the lack of endoPG genes. On the other hand, TH possessed an unidentified M haplotype that is involved in determination of MF phenotype. Structural identification of the unknown M haplotype, designated as M-0, through comparison with previously reported M haplotypes revealed distinct differences between PGM on M-0 haplotype (PGM-M-0) and PGM on other haplotypes (PGM-M-1). Peach M haplotypes were classified into four main haplotypes: M-0 with PGM-M-0; M-1 with both PGM-M-1 and PGF; M-2 with PGM-M-1; and M-3 lacking both PGM and PGF. Re-evaluation of M locus in association with MF/non-melting flesh (NMF) phenotypes in more than 400 accessions by using whole genome shotgun sequencing data on database and/or by PCR genotyping demonstrated that M-0 haplotype was the common haplotype in MF accessions, and M-0 and M-1 haplotypes were dominant over M-2 and M-3 haplotypes and co-dominantly determined the MF trait. It was also assumed on the basis of structural comparison of M haplotypes among Prunus species that the ancestral haplotype of M-0 diverged from those of the other haplotypes before the speciation of Prunus persica. en-copyright= kn-copyright= en-aut-name=NakanoRyohei en-aut-sei=Nakano en-aut-mei=Ryohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawaiTakashi en-aut-sei=Kawai en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FukamatsuYosuke en-aut-sei=Fukamatsu en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AkitaKagari en-aut-sei=Akita en-aut-mei=Kagari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WatanabeSakine en-aut-sei=Watanabe en-aut-mei=Sakine kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AsanoTakahiro en-aut-sei=Asano en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakataDaisuke en-aut-sei=Takata en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SatoMamoru en-aut-sei=Sato en-aut-mei=Mamoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FukudaFumio en-aut-sei=Fukuda en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=UshijimaKoichiro en-aut-sei=Ushijima en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Experimental Farm of Graduate School of Agriculture, Kyoto University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=7 en-affil=Faculty of Food and Agricultural Sciences, Fukushima University kn-affil= affil-num=8 en-affil=Faculty of Food and Agricultural Sciences, Fukushima University kn-affil= affil-num=9 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=10 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= en-keyword=fruit kn-keyword=fruit en-keyword=softening kn-keyword=softening en-keyword=ethylene kn-keyword=ethylene en-keyword=Prunus persica kn-keyword=Prunus persica en-keyword=melting flesh locus kn-keyword=melting flesh locus en-keyword=endoPG kn-keyword=endoPG en-keyword=postharvest kn-keyword=postharvest END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=6 article-no= start-page=551 end-page=556 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=C-Arm-Free Minimally Invasive Cervical Pedicle Screw Fixation (MICEPS): A Technical Note en-subtitle= kn-subtitle= en-abstract= kn-abstract=A minimally invasive posterolateral approach designed to avoid the lateral misplacement of midcervical pedicle screws was reported, but there is no technical report that describes this technique without C-arm fluoroscopy. We report the results of a 2.5 years follow-up of a 62-year-old female patient with C4 metastatic breast cancer. The patient suffered from severe neck pain and impending quadriplegia for 2 months after radiation therapy. We performed C-arm-free minimally invasive cervical pedicle screw fixation (MICEPS). The patient was suc-cessfully treated with surgery, and her neck pain was well controlled. She had neither neurological deficits nor neck pain at the final (2.5-year) follow-up. C-arm-free MICEPS is a useful technique; in addition, the sur-geons and staff have no risk of radiation exposure, there is a reduced need for postoperative imaging, and a decreased revision rate can be expected with C-arm-free MICEPS. en-copyright= kn-copyright= en-aut-name=TanakaMasato en-aut-sei=Tanaka en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiwaraYoshihiro en-aut-sei=Fujiwara en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UotaniKoji en-aut-sei=Uotani en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KadiriVenkatesh en-aut-sei=Kadiri en-aut-mei=Venkatesh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamauchiTaro en-aut-sei=Yamauchi en-aut-mei=Taro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= affil-num=2 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= affil-num=3 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= affil-num=4 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= affil-num=5 en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital kn-affil= en-keyword=cervical spine kn-keyword=cervical spine en-keyword=navigation surgery kn-keyword=navigation surgery en-keyword=minimally invasive surgery kn-keyword=minimally invasive surgery en-keyword=cervical pedicle screw kn-keyword=cervical pedicle screw en-keyword=C-arm free kn-keyword=C-arm free END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=6 article-no= start-page=531 end-page=535 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Soft Tissue Myoepithelioma of the Shoulder en-subtitle= kn-subtitle= en-abstract= kn-abstract=Soft tissue myoepitheliomas are often misdiagnosed due to their rarity. Herein, we describe a case of soft tissue myoepithelioma of the shoulder. A 72-year-old woman had a suspected sarcoma on her shoulder and under-went open biopsy. She was referred to our hospital, where the tumor was widely resected and the diagnosis of myoepithelioma was histologically confirmed. No recurrence has been observed in the 3 years since the sur-gery. Careful and prompt planning is necessary for the effective treatment of myoepithelioma. en-copyright= kn-copyright= en-aut-name=HashimotoKazuhiko en-aut-sei=Hashimoto en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishimuraShunji en-aut-sei=Nishimura en-aut-mei=Shunji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ChikugoTakaaki en-aut-sei=Chikugo en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KakinokiRyosuke en-aut-sei=Kakinoki en-aut-mei=Ryosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AkagiMasao en-aut-sei=Akagi en-aut-mei=Masao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Orthopedic Surgery, Kindai University Hospital kn-affil= affil-num=2 en-affil=Department of Orthopedic Surgery, Kindai University Hospital kn-affil= affil-num=3 en-affil=Department of Pathology, Kindai University Hospital kn-affil= affil-num=4 en-affil=Department of Orthopedic Surgery, Kindai University Hospital kn-affil= affil-num=5 en-affil=Department of Orthopedic Surgery, Kindai University Hospital kn-affil= en-keyword=soft tissue myoepithelioma kn-keyword=soft tissue myoepithelioma en-keyword=unplanned resection kn-keyword=unplanned resection en-keyword=shoulder kn-keyword=shoulder END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=6 article-no= start-page=483 end-page=493 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Potential of Artificial Intelligence for Estimating Japanese Fetal Weights en-subtitle= kn-subtitle= en-abstract= kn-abstract=We developed an artificial intelligence (AI) method for estimating fetal weights of Japanese fetuses based on the gestational weeks and the bi-parietal diameter, abdominal circumference, and femur length. The AI comprised of neural network architecture was trained by deep learning with a dataset that consists of ± 2 standard devia-tion (SD), ± 1.5SD, and ± 0SD categories of the approved standard values of ultrasonic measurements of the fetal weights of Japanese fetuses (Japan Society of Ultrasonics in Medicine [JSUM] data). We investigated the residuals and compared 2 other regression formulae for estimating the fetal weights of Japanese fetuses by t-test and Bland-Altman analyses, respectively. The residuals of the AI for the test dataset that was 12.5% of the JSUM data were 6.4 ± 2.6, −3.8 ± 8.6, and −0.32 ± 6.3 (g) at −2SD, +2SD, and all categories, respectively. The residu-als of another AI method created with all of the JSUM data, of which 20% were randomized validation data, were −1.5 ± 9.4, −2.5 ± 7.3, and −1.1 ± 6.7 (g) for −2SD, +2SD, and all categories, respectively. The residuals of this AI were not different from zero, whereas those of the published formulae differed from zero. Though vali-dation is required, the AI demonstrated potential for generating fetal weights accurately, especially for extreme fetal weights. en-copyright= kn-copyright= en-aut-name=MiyagiYasunari en-aut-sei=Miyagi en-aut-mei=Yasunari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyakeTakahito en-aut-sei=Miyake en-aut-mei=Takahito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Medical Data Labo kn-affil= affil-num=2 en-affil=Department of Obstetrics and Gynecology, Miyake Clinic kn-affil= en-keyword=deep learning kn-keyword=deep learning en-keyword=artificial intelligence kn-keyword=artificial intelligence en-keyword=fetal weight kn-keyword=fetal weight en-keyword=neural network kn-keyword=neural network en-keyword=ultrasound biometry kn-keyword=ultrasound biometry END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=5 article-no= start-page=381 end-page=389 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical Relevance of Serum Prolactin Levels to Inflammatory Reaction in Male Patients en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the relevance of prolactin (PRL) to clinical parameters in patients who visited our general medicine department, medical records of 353 patients in whom serum PRL levels were measured during the period from 2016 to 2018 were retrospectively reviewed. Data for 140 patients (M/F: 42/98) were analyzed after excluding patients lacking detailed records and patients taking dopaminergic agents. Median serum PRL levels were significantly lower in males than females: 6.5 ng/ml (IQR: 4.2-10.3) versus 8.1 ng/ml (5.9-12.9), respectively. Pain and general fatigue were the major symptoms at the first visit, and past histories of hypertension and dyslipidemia were frequent. Male patients with relatively high PRL levels (≥ 10 ng/ml) had significantly lower levels of serum albumin and significantly higher levels of serum LDH than those with low PRL (< 10 ng/ml). There were significant correlations of male PRL level with the erythrocyte sedimentation rate (R=0.62), serum LDH level (R=0.39) and serum albumin level (R=−0.52), while the level of serum CRP (R=0.33) showed an insignificant but weak positive correlation with PRL level. Collectively, these results show that PRL levels had gender-specific relevance to various clinical factors, with PRL levels in males being significantly related to inflammatory status. en-copyright= kn-copyright= en-aut-name=YamamotoKoichiro en-aut-sei=Yamamoto en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HanayamaYoshihisa en-aut-sei=Hanayama en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HasegawaKou en-aut-sei=Hasegawa en-aut-mei=Kou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TokumasuKazuki en-aut-sei=Tokumasu en-aut-mei=Kazuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyoshiTomoko en-aut-sei=Miyoshi en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OgawaHiroko en-aut-sei=Ogawa en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ObikaMikako en-aut-sei=Obika en-aut-mei=Mikako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ItoshimaKoichi en-aut-sei=Itoshima en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Laboratory Medicine, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=hormones kn-keyword=hormones en-keyword=hyperprolactinemia kn-keyword=hyperprolactinemia en-keyword=inflammation kn-keyword=inflammation en-keyword=pituitary kn-keyword=pituitary en-keyword=prolactin kn-keyword=prolactin END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=3 article-no= start-page=343 end-page=344 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Elite Malay Polygamy: Wives, Wealth and Woes in Malaysia. Koktvedgaard Zeitzen, Miriam. New York: Berghahn, 2018. 268 pp. en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakataniAyami en-aut-sei=Nakatani en-aut-mei=Ayami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=4 article-no= start-page=265 end-page=274 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202008 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Factors Predicting a Favorable Disease Course Without Anti-TNF Therapy in Crohn’s Disease Patients en-subtitle= kn-subtitle= en-abstract= kn-abstract=Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy. en-copyright= kn-copyright= en-aut-name=InokuchiToshihiro en-aut-sei=Inokuchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YasutomiEriko en-aut-sei=Yasutomi en-aut-mei=Eriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkaShohei en-aut-sei=Oka en-aut-mei=Shohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamasakiYasushi en-aut-sei=Yamasaki en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KinugasaHideaki en-aut-sei=Kinugasa en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakaharMasahiro en-aut-sei=Takahar en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HaradaKeita en-aut-sei=Harada en-aut-mei=Keita kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KatoJun en-aut-sei=Kato en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=bDepartment of Gastroenterology, Mitsui Memorial Hospital kn-affil= en-keyword=Crohn’s disease kn-keyword=Crohn’s disease en-keyword=anti-TNF agent kn-keyword=anti-TNF agent en-keyword=upper gastrointestinal lesion kn-keyword=upper gastrointestinal lesion en-keyword=bamboo joint-like appearance kn-keyword=bamboo joint-like appearance END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=3 article-no= start-page=261 end-page=264 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202006 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Randomized Phase 2 Trial of Antibiotic Prophylaxis Versus No Intervention for Muscle Biopsy in A Neurology Department en-subtitle= kn-subtitle= en-abstract= kn-abstract=Muscle biopsy can be used to confirm the diagnosis of neuromuscular diseases. However, it is unclear whether antibiotic prophylaxis prior to muscle biopsy is needed to prevent surgical site infection (SSI). We are conducting a phase 2, single-center, open-labeled, prospective randomized trial to clarify the need for antibiotic prophylaxis in patients at low risk for SSI undergoing muscle biopsy. Patients will be randomized to an antibiotic prophylaxis group or a control group, and the incidence of SSI will be compared between the groups. Our findings will clarify the need for antibiotic prophylaxis in this patient population. en-copyright= kn-copyright= en-aut-name=NakaharaKeiichi en-aut-sei=Nakahara en-aut-mei=Keiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkedaTokunori en-aut-sei=Ikeda en-aut-mei=Tokunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakamatsuKoutaro en-aut-sei=Takamatsu en-aut-mei=Koutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TawaraNozomu en-aut-sei=Tawara en-aut-mei=Nozomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HaraKentaro en-aut-sei=Hara en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=EnokidaYuki en-aut-sei=Enokida en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanoueNaomi en-aut-sei=Tanoue en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NaritaSawana en-aut-sei=Narita en-aut-mei=Sawana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujiiAkiko en-aut-sei=Fujii en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamanouchiYoshinori en-aut-sei=Yamanouchi en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MorinagaJun en-aut-sei=Morinaga en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YamashitaSatoshi en-aut-sei=Yamashita en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medical Sciences, Kumamoto University kn-affil= affil-num=2 en-affil= Department of Clinical Investigation, Kumamoto University Hospital kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medical Sciences, Kumamoto University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medical Sciences, Kumamoto University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medical Sciences, Kumamoto University kn-affil= affil-num=6 en-affil=Department of Pharmacy, Kumamoto University Hospital kn-affil= affil-num=7 en-affil=Department of Pharmacy, Kumamoto University Hospital kn-affil= affil-num=8 en-affil=Department of Clinical Investigation, Kumamoto University Hospital kn-affil= affil-num=9 en-affil=Department of Clinical Investigation, Kumamoto University Hospital kn-affil= affil-num=10 en-affil=Department of Clinical Investigation, Kumamoto University Hospital kn-affil= affil-num=11 en-affil=Department of Clinical Investigation, Kumamoto University Hospital kn-affil= affil-num=12 en-affil=Department of Neurology, Graduate School of Medical Sciences, Kumamoto University kn-affil= en-keyword=muscle biopsy kn-keyword=muscle biopsy en-keyword=antibiotic prophylaxis kn-keyword=antibiotic prophylaxis END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=1 article-no= start-page=22 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=2020 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of Defoliation on Blossom-end Rot Incidence and Calcium Transport into Fruit of Tomato Cultivars Under Moderate Water Stress en-subtitle= kn-subtitle= en-abstract= kn-abstract=The translocation of calcium (Ca) within the tomato plant and the causes of Ca deficiency, a factor associated with blossom-end rot (BER) in fruit, are still a matter of conjecture. The objective of this study was to determine the effect of defoliation on BER incidence and Ca transport into different size tomato fruit cultivars. Four experiments were conducted. The start and end dates for each experiment were; 14 March–2 May, 22 July–23 August, 30 August–7 October 2017, and 20 May–25 June 2018, for experiments 1, 2, 3, and 4, respectively. Five tomato cultivars including one large (‘Momotaro fight (MF)’, ≥ 200 g), three medium (‘Lui 60 (L60)’, ‘Tio cook (TC)’, and ‘Cindy sweet (CS)’, 30–80 g), and one small (‘Pepe (PP)’, ≤ 20 g) fruit cultivars, respectively, were grown under moderate water stress controlled by a combination of root zone restriction and solar mediated fertigation. Leaf area of plants was reduced by 20–30% by removing alternate leaflets on all leaves. Defoliation significantly reduced BER in all experiments. In experiment 4, no BER was observed in defoliated plants of L60 and PP, and in MF and TC, BER incidence decreased to a quarter of the control. Defoliation increased the fruit growth rate (FGR) in experiment 1, in which the temperature was the lowest, by a ratio of 1.42 and by 1.39 in experiment 4, in which the radiation was strongest and day length longest. Defoliation increased the rate of daily Ca transport into fruit (CTR) in MF, L60, TC, CS, and PP by average ratios of 1.64, 1.55, 1.35, 1.30, and 1.13, respectively. The increase in CTR in defoliated plants was highest in experiment 4 with a ratio of 1.68 followed by 1.37, 1.33, and 1.28 in experiments 1, 3, and 2, respectively. Defoliation increased both FGR and CTR and there were significant linear relationships between them. However, the degree of increase was larger in CTR than that in FGR, especially in the BER-sensitive large fruit cultivar MF, and defoliation increased the total Ca concentration in fruit accordingly. We conclude that under moderate water stress by root zone restriction and certain other BER inductive conditions, defoliation could be a promising approach to reduce BER incidence by improving Ca nutrition in susceptible large fruit cultivars. en-copyright= kn-copyright= en-aut-name=IndecheAnnah Khatenje en-aut-sei=Indeche en-aut-mei=Annah Khatenje kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshidaYuichi en-aut-sei=Yoshida en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=GotoTanjuro en-aut-sei=Goto en-aut-mei=Tanjuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YasubaKen-ichiro en-aut-sei=Yasuba en-aut-mei=Ken-ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanakaYoshiyuki en-aut-sei=Tanaka en-aut-mei=Yoshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=2 article-no= start-page=95 end-page=101 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Efficacy of Software to Help Patients Understand Drug for Adjuvant Treatment for Breast Cancer: A Pilot Randomized Controlled Trial en-subtitle= kn-subtitle= en-abstract= kn-abstract= We assessed the usefulness of ChemoCalc, a software package for calculating drug costs, in helping patients understand these costs. We randomly assigned, in a 1 : 1 ratio, 20 women who had undergone surgery for early breast cancer to a group that discussed adjuvant treatment with their physicians using the ChemoCalc software (ChemoCalc group) or a group that discussed adjuvant treatment without ChemoCalc (Usual Explanation group). The participants completed a five-grade evaluation questionnaire after these discussions. The primary endpoint was the intergroup comparison of the questionnaire scores regarding participants’ understanding of their treatment-associated drug costs. Median age was not significantly different between the ChemoCalc group and Usual Explanation group (57 vs. 50, respectively; p=0.27). Patients in the ChemoCalc group had a significantly higher perceived level of understanding of the drug cost than those in the Usual Explanation group (5 [4-5] vs. 2.5 [1-5], respectively; p=0.002). Scores related to the patients’ perception that understanding drug costs is an important part of breast cancer treatment were also higher in the ChemoCalc group than the Usual Explanation group (5 [2-5] vs. 3 [1-5], respectively; p=0.049). ChemoCalc was found to be useful for understanding drug costs. en-copyright= kn-copyright= en-aut-name=KubaSayaka en-aut-sei=Kuba en-aut-mei=Sayaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamanouchiKosho en-aut-sei=Yamanouchi en-aut-mei=Kosho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MoritaMichi en-aut-sei=Morita en-aut-mei=Michi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakimuraChika en-aut-sei=Sakimura en-aut-mei=Chika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=InamasuEiko en-aut-sei=Inamasu en-aut-mei=Eiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HatachiToshiko en-aut-sei=Hatachi en-aut-mei=Toshiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OtsuboRyota en-aut-sei=Otsubo en-aut-mei=Ryota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MatsumotoMegumi en-aut-sei=Matsumoto en-aut-mei=Megumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YanoHiroshi en-aut-sei=Yano en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MiyamotoJunya en-aut-sei=Miyamoto en-aut-mei=Junya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SatoShuntaro en-aut-sei=Sato en-aut-mei=Shuntaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NakagawaHiroo en-aut-sei=Nakagawa en-aut-mei=Hiroo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KanetakaKengo en-aut-sei=Kanetaka en-aut-mei=Kengo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=TakatsukiMitsuhisa en-aut-sei=Takatsuki en-aut-mei=Mitsuhisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=NagayasuTakeshi en-aut-sei=Nagayasu en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=EguchiSusumu en-aut-sei=Eguchi en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=2 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=3 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=4 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=5 en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=6 en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=7 en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=8 en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=9 en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=10 en-affil=Department of Clinical Research Center, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=11 en-affil=Department of Clinical Research Center, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=12 en-affil=Department of Pharmacy, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=13 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=14 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=15 en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=16 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= en-keyword=breast cancer kn-keyword=breast cancer en-keyword=drug costs kn-keyword=drug costs en-keyword=ChemoCalc kn-keyword=ChemoCalc END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=6 article-no= start-page=487 end-page=494 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Foveal Structural Analysis of Amblyopic Eyes with Two Types of Fixation Behavior by Spectral-Domain Optical Coherence Tomography en-subtitle= kn-subtitle= en-abstract= kn-abstract= We used spectral-domain optical coherence tomography (SD-OCT) to compare the foveal and parafoveal structures of 19 subjects aged 16-58 years (8 men, 11 women): 6 amblyopic patients with eccentric fixation, 5 amblyopic patients with central fixation, and 8 visually normal controls. We obtained foveal horizontal line scans using SD-OCT on all of the patients and controls. The total and layer thicknesses at foveal areas were analyzed. The mean (SD) ages of individuals in the eccentric fixation, central fixation, and control groups were 43.0 (13.9), 42.2 (16.3), and 38.5 (15.5) years, respectively. We observed no significant differences in the foveal or parafoveal retinal thicknesses at 500 and 1,500 μm from the foveal center among the 3 groups or between the amblyopic and fellow eyes. No significant differences were observed in the thickness of the ganglion cell complex layer or outer retinal layer at 500 and 1,500 μm from the foveal center among the three groups or between the two eyes. Overall, our SD-OCT analyses revealed no characteristic structural change in foveal regions in amblyopic eyes irrespective of the fixation behavior. en-copyright= kn-copyright= en-aut-name=KishimotoFumiko en-aut-sei=Kishimoto en-aut-mei=Fumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiiChiaki en-aut-sei=Fujii en-aut-mei=Chiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkanouchiToshio en-aut-sei=Okanouchi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhtsukiHiroshi en-aut-sei=Ohtsuki en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Phamaceutical Sciences kn-affil= affil-num=2 en-affil=Division of Ophthalmology, Ibara Municipal Hospital kn-affil= affil-num=3 en-affil=Division of Ophthalmology, Kurashiki Medical Center kn-affil= affil-num=4 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Phamaceutical Sciences kn-affil= en-keyword=foveal structure kn-keyword=foveal structure en-keyword=strabismic amblyopia kn-keyword=strabismic amblyopia en-keyword=optical coherence tomography kn-keyword=optical coherence tomography en-keyword=eccentric fixation kn-keyword=eccentric fixation END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=5 article-no= start-page=463 end-page=468 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Twist Knot: A New Sliding Noose in Adjustable Suture Strabismus Surgery en-subtitle= kn-subtitle= en-abstract= kn-abstract= To permit noose movement without fraying the sutures following strabismus surgery, we designed a new sliding noose, the “twist knot” and investigated its advantages and disadvantages. We measured the tensile strength required to move the twist knot in a tightly tied state (134±19 gf) and in a loosened state (21±7 gf), and that required to move the conventional sliding noose in a tightly tied state (48±14 gf), and used the Kruskal-Wallis test to compare them. A significant difference was observed among the three tensile strengths (p<0.001). The twist knot technique allowed easy sliding without the multifilament braided suture becoming frayed and a knot to be firmly fixed without slipping. However, if the 2 strings of the pole sutures exit from the sclera at 2 widely separated positions, the sliding noose may become slack. Therefore, the distance between the pole sutures should be small. The simple twist knot technique was found to be an effective approach following adjustable surgery of strabismus. en-copyright= kn-copyright= en-aut-name=ShibataKiyo en-aut-sei=Shibata en-aut-mei=Kiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HamasakiIchiro en-aut-sei=Hamasaki en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShimizuTakehiro en-aut-sei=Shimizu en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KonoReika en-aut-sei=Kono en-aut-mei=Reika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OhtsukiHiroshi en-aut-sei=Ohtsuki en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MorizaneYuki en-aut-sei=Morizane en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShiragaFumio en-aut-sei=Shiraga en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Ophthalmology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Ophthalmology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Ophthalmology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of Ophthalmology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Ophthalmology, Okayama Saiseikai General Hospital kn-affil= affil-num=6 en-affil=Department of Ophthalmology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Ophthalmology, Okayama University Hospital kn-affil= en-keyword=adjustable suture kn-keyword=adjustable suture en-keyword=the new sliding noose method kn-keyword=the new sliding noose method en-keyword=tensile strength kn-keyword=tensile strength en-keyword=strabismus surgery kn-keyword=strabismus surgery en-keyword=esotropia kn-keyword=esotropia END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=5 article-no= start-page=393 end-page=401 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Developing Microsurgery through Experience in Yangon General Hospital, Myanmar en-subtitle= kn-subtitle= en-abstract= kn-abstract= Although many surgical centers perform microsurgery routinely in developed countries, performing microsurgery is challenging in resource-poor developing countries, such as Myanmar. With the establishment of educational training programs and the assistance of volunteer plastic surgical teams, local plastic surgeons can learn the techniques of microsurgery and apply them clinically. The purpose of this study was to establish baseline data and define the challenges of performing microsurgery in Yangon General Hospital, Myanmar. Sixty-four patients underwent reconstruction with free flaps from January 2015 to January 2018. All clinical records of these cases were assessed. The number of free flap reconstructions performed increased from 11 in the first year to 24 in the third year. The anterolateral thigh flap was the most commonly used (42%). The most common sites of reconstruction were mandible and intraoral defects. Total flap survival occurred in 58 of 64 patients (89%). The total salvageable flap rate for revision surgery was 66.6%; the successful revision rate was highest in 2017, with fewer complications. The flap salvage rates increased and the operative duration decreased as clinical experience improved. Establishing a microsurgical center requires a strong multidisciplinary team, clinical experience, continuous learning, sensible clinical application, and effective interdepartmental and intradepartmental cooperation. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Yi Yi Cho Thein kn-aut-sei=Yi Yi Cho Thein kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WinMyitzu en-aut-sei=Win en-aut-mei=Myitzu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ThuzaraMoe en-aut-sei=Thuzara en-aut-mei=Moe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsumotoHiroshi en-aut-sei=Matsumoto en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamadaKiyoshi en-aut-sei=Yamada en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=LeungMichael en-aut-sei=Leung en-aut-mei=Michael kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Plastic, Maxillofacial and Oral Surgery, Yangon General Hospital, University of Medicine (1) kn-affil= affil-num=2 en-affil=Department of Plastic, Maxillofacial and Oral Surgery, Yangon General Hospital, University of Medicine (1) kn-affil= affil-num=3 en-affil=Department of Plastic, Maxillofacial and Oral Surgery, Yangon General Hospital, University of Medicine (1) kn-affil= affil-num=4 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Plastic and Reconstructive Surgery, Monash Health kn-affil= en-keyword=microsurgery kn-keyword=microsurgery en-keyword=educational programs kn-keyword=educational programs en-keyword=challenges of microsurgical free flaps kn-keyword=challenges of microsurgical free flaps en-keyword=reoperation kn-keyword=reoperation en-keyword=flap salvageable rate kn-keyword=flap salvageable rate END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=4 article-no= start-page=307 end-page=313 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201908 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Impact of Disease Complexity on Cardiovascular Events after the Transition to an Adult Congenital Heart Disease Specialized Medical Unit en-subtitle= kn-subtitle= en-abstract= kn-abstract= The follow-up of patients with adult congenital heart disease (ACHD) at a specialized medical unit is necessary for the patients’ appropriate medical care. However, limited information is available about cardiovascular events among ACHD patients. Here we investigated the type and frequency of cardiovascular events in ACHD patients in relation to disease complexity. We retrospectively analyzed the cases of 535 patients (median age 35 years) referred to our ACHD center between 2014 and 2017. We divided the patients into 3 groups based on their disease complexity. To evaluate the relationship between disease complexity and cardiovascular events, we performed univariate and multivariate survival analyses. The Simple, moderate, and complex disease groups accounted for 62%, 19%, and 19% of the patients, respectively. Apart from events related to atrial septal defect (ASD) trans-catheter treatment, the frequency of cardiovascular events was dependent on the disease complexity (event-free survival rates at 3 years were 85%, 65%, and 58%, respectively). The hazard ratios were 4.0 and 5.1 in the moderate and complex groups, respectively. With the exception of scheduled transcatheter intervention, cardiovascular events were strongly related to the disease complexity of original heart disease. However, cardiovascular events were not rare even in the simple ACHD group. en-copyright= kn-copyright= en-aut-name=TakahashiSho en-aut-sei=Takahashi en-aut-mei=Sho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AkagiTeiji en-aut-sei=Akagi en-aut-mei=Teiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TohNorihisa en-aut-sei=Toh en-aut-mei=Norihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakayaYoichi en-aut-sei=Takaya en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakagawaKoji en-aut-sei=Nakagawa en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NishiiNobuhiro en-aut-sei=Nishii en-aut-mei=Nobuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ItoHiroshi en-aut-sei=Ito en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=congenital heart defect kn-keyword=congenital heart defect en-keyword=congenital in adults kn-keyword=congenital in adults en-keyword=hospitalization kn-keyword=hospitalization en-keyword=cardiovascular event kn-keyword=cardiovascular event END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=3 article-no= start-page=255 end-page=262 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Improvement of Open Bite and Stomatognathic Function in an Axenfeld- Rieger Syndrome Patient by Orthodontic Sectional Arch Mechanics: Clinical Considerations and the Risk of Orthodontic Tooth Movement en-subtitle= kn-subtitle= en-abstract= kn-abstract= Orthodontists need to understand the orthodontic risks associated with systemic disorders. Axenfeld-Rieger syndrome (ARS) is a rare autosomal dominant disorder with genetic and morphological variability. The risks of orthodontic treatment in ARS patients have been unclear. Here we describe the correction of an anterior open bite in a 15-year-old Japanese female ARS patient by molar intrusion using sectional archwires with miniscrew implants. An undesirable development of external apical root resorption (EARR) was observed in all intrusive force-applied posterior teeth during the patient’s orthodontic treatment, suggesting that ARS patients have a higher risk of EARR than the general population. en-copyright= kn-copyright= en-aut-name=SekiDaisuke en-aut-sei=Seki en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakeshitaNobuo en-aut-sei=Takeshita en-aut-mei=Nobuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SeiryuMasahiro en-aut-sei=Seiryu en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DeguchiToru en-aut-sei=Deguchi en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=Takano-YamamotoTeruko en-aut-sei=Takano-Yamamoto en-aut-mei=Teruko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry kn-affil= affil-num=2 en-affil=Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry kn-affil= affil-num=3 en-affil=Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry kn-affil= affil-num=4 en-affil=Division of Orthodontics, The Ohio State University College of Dentistry kn-affil= affil-num=5 en-affil=Department of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University kn-affil= en-keyword=Axenfeld-Rieger syndrome kn-keyword=Axenfeld-Rieger syndrome en-keyword=external apical root resorption kn-keyword=external apical root resorption en-keyword=miniscrew implant kn-keyword=miniscrew implant en-keyword=anterior open bite kn-keyword=anterior open bite END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=3 article-no= start-page=235 end-page=240 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prevalence of and Risk Factors for the Progression of Upper Cervical Lesions in Patients with Rheumatoid Arthritis en-subtitle= kn-subtitle= en-abstract= kn-abstract= We investigated the prevalence of and risk factors for the progression of upper cervical lesions (UCLs) in patients with rheumatoid arthritis (RA). A retrospective analysis of 49 patients with RA (4 males, 45 females) was conducted. The UCLs included atlanto-axial subluxation and vertical subluxation. We investigated the clinical factors including the Disease Activity Score 28 based on C-reactive protein (DAS28-CRP) and the modified Health Assessment Questionnaire-Disability Index as well as radiographic changes between the baseline (at May 2010 to April 2013) and final follow-up. Forty patients (81.6%) were classified as the non-progressive group, and the other 9 patients (18.4%) comprised the progressive group. The progressive group’s final CRP values, baseline or final MMP-3 levels, DAS28-CRP, and rate of pre-existing lesions at baseline were all significantly higher than those of the non-progressive group (p=0.017, p=0.043, p=0.002, p=0.008, p<0.001, and p=0.008 respectively). A multivariate logistic regression analysis demonstrated that DAS28-CRP at baseline was a risk factor for radiographic progression (p=0.018, odds ratio: 2.54, 95% confidence interval: 1.17-5.51). Our findings indicate that higher disease activity might influence the progression of UCLs in patients with RA. en-copyright= kn-copyright= en-aut-name=HoritaMasahiro en-aut-sei=Horita en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishidaKeiichiro en-aut-sei=Nishida en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HashizumeKenzo en-aut-sei=Hashizume en-aut-mei=Kenzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SugimotoYoshihisa en-aut-sei=Sugimoto en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NasuYoshihisa en-aut-sei=Nasu en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakaharaRyuichi en-aut-sei=Nakahara en-aut-mei=Ryuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HaradaRyozo en-aut-sei=Harada en-aut-mei=Ryozo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Rehabilitation, Japan Labour Health and Walfare Organization, Okayama Rosai Hospital kn-affil= affil-num=4 en-affil=Department of Orthopaedic Surgery, Okayama City Hospital kn-affil= affil-num=5 en-affil=Department of Medical Materials for Musculoskeletal Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Intelligent Orthopaedic ystem, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=rheumatoid arthritis kn-keyword=rheumatoid arthritis en-keyword=upper cervical spine lesion kn-keyword=upper cervical spine lesion en-keyword=risk factor kn-keyword=risk factor en-keyword=radiological progression kn-keyword=radiological progression END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=3 article-no= start-page=213 end-page=221 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Spiral Trajectory Modulation of Rheotaxic Motile Human Sperm in Cylindrical Microfluidic Channels of Different Inner Diameters en-subtitle= kn-subtitle= en-abstract= kn-abstract= We investigated the relationship between human sperm rheotaxis and motile sperm trajectories by using poly-(dimethylsiloxane) (PDMS)-based cylindrical microfluidic channels with inner diameters of 100 μm, 50 μm, and 70 μm, which corresponded to the inner diameter of the human isthmus, the length of a sperm and a diameter intermediate between the two, respectively. We counted the number of rheotaxic sperm and sperm with spiral motion. We also analyzed motile sperm trajectories. As the cylindrical channel diameter was decreased, the percentage of sperm cells exhibiting rheotaxis, the percentage of sperm cells exhibiting spiral motion, the frequency-to-diameter ratio of the sperm cells’ spiral trajectories, and the surface area of the microfluidic channel increased, while the flagellar motion at the channel wall decreased. The percentage of sperm exhibiting a spiral trajectory and the frequency-to-diameter ratio of the sperm cells’ spiral trajectories were thus affected by the channel diameter. Our findings suggest that the oviduct structure affects the swimming properties of sperm cells, guiding them from the uterus to the ampulla for egg fertilization. These results could contribute to the development of motile sperm-sorting microfluidic devices for assisted reproductive technologies. en-copyright= kn-copyright= en-aut-name=NishinaSaori en-aut-sei=Nishina en-aut-mei=Saori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuuraKoji en-aut-sei=Matsuura en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NaruseKeiji en-aut-sei=Naruse en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Biomedical Engineering, Faculty of Engineering, Okayama University of Science kn-affil= affil-num=3 en-affil=Cardiovascular Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=sperm motility kn-keyword=sperm motility en-keyword=trajectory kn-keyword=trajectory en-keyword=microfluidic channel kn-keyword=microfluidic channel en-keyword=rheotaxis kn-keyword=rheotaxis en-keyword=oviduct structure kn-keyword=oviduct structure END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=1 article-no= start-page=71 end-page=76 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Efficacy of Oral Care Provided by Interprofessional Collaboration for a Patient with Esophageal Cancer Associated with Post-polio Syndrome during Neoadjuvant Chemotherapy en-subtitle= kn-subtitle= en-abstract= kn-abstract= Preoperative oral care is helpful to prevent postoperative complications in patients who are undergoing esophagectomy. Here, we report the case of an 81-year-old Japanese man with an upper limb disability caused by post-polio syndrome who was receiving neoadjuvant chemotherapy for esophageal cancer. He had poor oral health status and developed oral complications as a side effect of chemotherapy. He could not brush his teeth by himself. However, infection control by oral care provided by an interprofessional collaboration successfully improved his oral hygiene, and his follow-up involved no severe complications. Interprofessional collaboration is useful especially for patients with upper limb disability. en-copyright= kn-copyright= en-aut-name=Takahashi-ArimasaKeiko en-aut-sei=Takahashi-Arimasa en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=Kohno-YamanakaReiko en-aut-sei=Kohno-Yamanaka en-aut-mei=Reiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SogaYoshihiko en-aut-sei=Soga en-aut-mei=Yoshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiuraRumi en-aut-sei=Miura en-aut-mei=Rumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MoritaManabu en-aut-sei=Morita en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Dental Hygienist Team, Division of Medical Technology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Division of Hospital Dentistry, Central Clinical Department, Okayama University Hospital kn-affil= affil-num=3 en-affil=Division of Hospital Dentistry, Central Clinical Department, Okayama University Hospital kn-affil= affil-num=4 en-affil=Dental Hygienist Team, Division of Medical Technology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=esophageal cancer kn-keyword=esophageal cancer en-keyword=preoperative oral care kn-keyword=preoperative oral care en-keyword=post-polio syndrome kn-keyword=post-polio syndrome en-keyword=neoadjuvant chemotherapy kn-keyword=neoadjuvant chemotherapy en-keyword=oral mucositis kn-keyword=oral mucositis END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=1 article-no= start-page=67 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Congenital Multiple Ocular Motor Nerve Palsy Complicated by Splitting of the Lateral Rectus Muscle en-subtitle= kn-subtitle= en-abstract= kn-abstract= We report a case of congenital multiple ocular motor nerve palsy combined with splitting of the lateral rectus muscle (LR). A 59-year-old Japanese female was investigated for worsening esotropia after corrective surgery. She presented with left hypertropia (35Δ) and esotropia (45-50Δ). Orbital magnetic resonance imaging (MRI) showed reduced belly sizes in the superior rectus, inferior rectus, and superior oblique muscles and splitting of the LR, extending from the origin to the belly, in the left eye. Splitting of the LR belly was detected on MRI in a case of congenital multiple ocular motor nerve palsy. en-copyright= kn-copyright= en-aut-name=KonoReika en-aut-sei=Kono en-aut-mei=Reika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimizuTakehiro en-aut-sei=Shimizu en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OhtsukiHiroshi en-aut-sei=Ohtsuki en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HamasakiIchiro en-aut-sei=Hamasaki en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShibataKiyo en-aut-sei=Shibata en-aut-mei=Kiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KishimotoFumiko en-aut-sei=Kishimoto en-aut-mei=Fumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MorizaneYuki en-aut-sei=Morizane en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShiragaFumio en-aut-sei=Shiraga en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Ophthalmology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Division of Ophthalmology, Okayama Saiseikai General Hospital kn-affil= affil-num=4 en-affil=Department of Ophthalmology, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Ophthalmology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Division of Ophthalmology, Ibara City Hospital kn-affil= affil-num=7 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=multiple ocular motor nerve palsy kn-keyword=multiple ocular motor nerve palsy en-keyword=congenital cranial dysinnervation disorder kn-keyword=congenital cranial dysinnervation disorder en-keyword=lateral rectus muscle splitting kn-keyword=lateral rectus muscle splitting en-keyword=orbital connective tissue kn-keyword=orbital connective tissue en-keyword=magnetic resonance imaging kn-keyword=magnetic resonance imaging END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue=6 article-no= start-page=2024 end-page=2032 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170509 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Induction of IL-17 production from human peripheral blood CD4+ cells by asbestos exposure en-subtitle= kn-subtitle= en-abstract= kn-abstract= We have previously reported that chronic, recurrent and low-dose exposure to asbestos fibers causes a reduction in antitumor immunity. Investigation of natural killer (NK) cells using an in vitro cell line model and comprising in vitro activation using freshly isolated NK cells co-cultured with chrysotile fibers, as well as NK cells derived from asbestos-exposed patients with pleural plaque (PP) or malignant mesothelioma (MM), revealed decreased expression of NK cell activating receptors such as NKG2D, 2B4 and NKp46. An in vitro differentiation and clonal expansion model for CD8+ cytotoxic T lymphocytes (CTLs) showed reduced cytotoxicity with decreased levels of cytotoxic molecules such as granzyme B and perforin, as well as suppressed proliferation of CTLs. Additionally, analysis of T helper cells showed that surface CXCR3, chemokine receptor, and the productive potential of interferon (IFN)γ were reduced following asbestos exposure in an in vitro cell line model and in peripheral CD4+ cells of asbestos-exposed patients. Moreover, experiments revealed that asbestos exposure enhanced regulatory T cell (Treg) function. This study also focused on CXCR3 expression and the Th-17 cell fraction. Following activation with T-cell receptor and co-culture with various concentrations of chrysotile fibers using freshly isolated CD4+ surface CXCR3 positive and negative fractions, the intracellular expression of CXCR3, IFNγ and IL-17 remained unchanged when co-cultured with chrysotile. However, subsequent re-stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin resulted in enhanced IL-17 production and expression, particularly in CD4+ surface CXCR3 positive cells. These results indicated that the balance and polarization between Treg and Th-17 fractions play an important role with respect to the immunological effects of asbestos and the associated reduction in antitumor immunity. en-copyright= kn-copyright= en-aut-name=MaedaMegumi en-aut-sei=Maeda en-aut-mei=Megumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ChenYing en-aut-sei=Chen en-aut-mei=Ying kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=LeeSuni en-aut-sei=Lee en-aut-mei=Suni kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=Kumagai-TakeiNaoko en-aut-sei=Kumagai-Takei en-aut-mei=Naoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YoshitomeKei en-aut-sei=Yoshitome en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsuzakiHidenori en-aut-sei=Matsuzaki en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamamotoShoko en-aut-sei=Yamamoto en-aut-mei=Shoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HatayamaTamayo en-aut-sei=Hatayama en-aut-mei=Tamayo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IkedaMiho en-aut-sei=Ikeda en-aut-mei=Miho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NishimuraYasumitsu en-aut-sei=Nishimura en-aut-mei=Yasumitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OtsukiTakemi en-aut-sei=Otsuki en-aut-mei=Takemi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Biofunctional Chemistry, Division of Bioscience, Okayama University Graduate School of Natural Science and Technology kn-affil= affil-num=2 en-affil= Department of Hygiene, Kawasaki Medical School kn-affil= affil-num=3 en-affil= Department of Hygiene, Kawasaki Medical School kn-affil= affil-num=4 en-affil= Department of Hygiene, Kawasaki Medical School kn-affil= affil-num=5 en-affil= Department of Hygiene, Kawasaki Medical School kn-affil= affil-num=6 en-affil= Department of Hygiene, Kawasaki Medical School kn-affil= affil-num=7 en-affil= Department of Hygiene, Kawasaki Medical School kn-affil= affil-num=8 en-affil= Department of Hygiene, Kawasaki Medical School kn-affil= affil-num=9 en-affil= Department of Hygiene, Kawasaki Medical School kn-affil= affil-num=10 en-affil= Department of Hygiene, Kawasaki Medical School kn-affil= affil-num=11 en-affil= Department of Hygiene, Kawasaki Medical School kn-affil= END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=201 end-page=205 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ectopic sebaceous glands in the esophagus that became evident over a three-year span kn-title=3 年間の内視鏡所見の変化を観察できた食道異所性皮脂腺の1 例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= A 43-year-old Japanese woman was diagnosed with ectopic sebaceous glands in the esophagus by esophagogastroduodenoscopy and biopsy. At the age of 46, typical ectopic sebaceous glands were recognized in the upper esophagus, whereas yellowish white granules were faintly observed in the lower esophagus. Esophagogastroduodenoscopy examinations were repeated when she was 47 and again at 50 years old, and the lesions in the lower esophagus had become more evident over the ensuing 3 years. Esophageal ectopic sebaceous glands are relatively infrequent, and there have been few case reports describing the progression of the endoscopic features. We also report the clinical and endoscopic features of the five similar cases with pathologically proven ectopic sebaceous glands in the esophagus. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=岩室雅也 kn-aut-sei=岩室 kn-aut-mei=雅也 aut-affil-num=1 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=2 ORCID= en-aut-name=HaradaKeita en-aut-sei=Harada en-aut-mei=Keita kn-aut-name=原田馨太 kn-aut-sei=原田 kn-aut-mei=馨太 aut-affil-num=3 ORCID= en-aut-name=KanzakiHiromitsu en-aut-sei=Kanzaki en-aut-mei=Hiromitsu kn-aut-name=神崎洋光 kn-aut-sei=神崎 kn-aut-mei=洋光 aut-affil-num=4 ORCID= en-aut-name=HoriKeisuke en-aut-sei=Hori en-aut-mei=Keisuke kn-aut-name=堀圭介 kn-aut-sei=堀 kn-aut-mei=圭介 aut-affil-num=5 ORCID= en-aut-name=KitaMasahide en-aut-sei=Kita en-aut-mei=Masahide kn-aut-name=喜多雅英 kn-aut-sei=喜多 kn-aut-mei=雅英 aut-affil-num=6 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=川野誠司 kn-aut-sei=川野 kn-aut-mei=誠司 aut-affil-num=7 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name=河原祥朗 kn-aut-sei=河原 kn-aut-mei=祥朗 aut-affil-num=8 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name=田中健大 kn-aut-sei=田中 kn-aut-mei=健大 aut-affil-num=9 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=山本和秀 kn-aut-sei=山本 kn-aut-mei=和秀 aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=3 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=7 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=8 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=9 en-affil=Department of Pathology, Okayama University Hospital kn-affil=岡山大学病院　病理診断科 affil-num=10 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 en-keyword=食道異所性脂腺（ectopic sebaceous glands in the esophagus） kn-keyword=食道異所性脂腺（ectopic sebaceous glands in the esophagus） en-keyword=粘膜下腫瘍（submucosal tumor） kn-keyword=粘膜下腫瘍（submucosal tumor） en-keyword=食道黄色腫（esophageal xanthoma） kn-keyword=食道黄色腫（esophageal xanthoma） END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=197 end-page=199 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Neuropathic pain due to metastatic invasive cancer successfully treated with intravenous lidocaine hydrochloride after failure of oral pregabalin kn-title=プレガバリン内服困難となった後にリドカイン塩酸塩静注が奏功した 転移性癌浸潤による神経障害性疼痛の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= The concomitant administration of adjuvant analgesics is recommended for neuropathic pain due to metastatic invasive cancer, because such pain may respond poorly to analgesic agents such as non-opioid analgesics and opioids. We report the case of a 44-year-old female patient with severe pain caused by a lumbosacral plexus injury associated with a failure of oral pregabalin（ 200 mg daily for 2 weeks）. We administered lidocaine hydrochloride（ drip infusion 960 mg/day）, which successfully relieved the pain. en-copyright= kn-copyright= en-aut-name=KunisueMitsuhisa en-aut-sei=Kunisue en-aut-mei=Mitsuhisa kn-aut-name=國末充央 kn-aut-sei=國末 kn-aut-mei=充央 aut-affil-num=1 ORCID= affil-num=1 en-affil=Tsubasa Clinic Okayama kn-affil=つばさクリニック岡山 en-keyword=緩和（palliative care） kn-keyword=緩和（palliative care） en-keyword=癌性疼痛（cancer pain） kn-keyword=癌性疼痛（cancer pain） en-keyword=腰仙骨神経叢障害（lumbosacral plexus disorders） kn-keyword=腰仙骨神経叢障害（lumbosacral plexus disorders） en-keyword=経口摂取困難（dysphagia） kn-keyword=経口摂取困難（dysphagia） en-keyword=リドカイン（lidocaine） kn-keyword=リドカイン（lidocaine） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=非小細胞肺癌細胞は代替受容体チロシンキナーゼの活性化によってALK阻害剤アレクチニブに耐性を獲得する kn-title=Non–Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IsozakiHideko en-aut-sei=Isozaki en-aut-mei=Hideko kn-aut-name=磯崎英子 kn-aut-sei=磯崎 kn-aut-mei=英子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=2 article-no= start-page=111 end-page=116 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Magnified observation of spontaneous morphological changes of duodenal follicular lymphoma kn-title=拡大内視鏡検査にて形態変化を観察しえた十二指腸濾胞性リンパ腫の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 63-year-old Japanese woman was diagnosed with duodenal follicular lymphoma. The initial esophagogastroduodenoscopic examination with magnifying observation revealed opaque white spots and enlarged whitish villi. Nine months later, esophagogastroduodenoscopy showed that the size of the lymphoma lesion decreased, and only opaque white spots were visible. The histological analysis of biopsy samples obtained during the initial endoscopy examination showed both neoplastic follicles and an inter-follicular infiltration of lymphoma cells, whereas the biopsy samples obtained at the endoscopy performed 9 months later showed only neoplastic follicle formation. These results suggest that the magnifying endoscopic features may reflect the underlying pathological mechanisms : enlarged whitish villi are probably due to lymphoma cell infiltration in the inter-follicular area, and opaque white spots are probably caused by neoplastic follicle formation. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=岩室雅也 kn-aut-sei=岩室 kn-aut-mei=雅也 aut-affil-num=1 ORCID= en-aut-name=TakataKatsuyoshi en-aut-sei=Takata en-aut-mei=Katsuyoshi kn-aut-name=高田尚良 kn-aut-sei=高田 kn-aut-mei=尚良 aut-affil-num=2 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=川野誠司 kn-aut-sei=川野 kn-aut-mei=誠司 aut-affil-num=3 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name=河原祥朗 kn-aut-sei=河原 kn-aut-mei=祥朗 aut-affil-num=4 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name=吉野正 kn-aut-sei=吉野 kn-aut-mei=正 aut-affil-num=5 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=2 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） affil-num=3 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院 光学医療診療部 affil-num=4 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院 光学医療診療部 affil-num=5 en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 en-keyword=消化管原発濾胞性リンパ腫（primary gastrointestinal follicular lymphoma） kn-keyword=消化管原発濾胞性リンパ腫（primary gastrointestinal follicular lymphoma） en-keyword=悪性リンパ腫（malignant lymphoma） kn-keyword=悪性リンパ腫（malignant lymphoma） en-keyword=拡大内視鏡検査（magnifying endoscopy） kn-keyword=拡大内視鏡検査（magnifying endoscopy） END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue= article-no= start-page=41 end-page=102 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=「土産写真帖」に見る植民地「ビルマ」のイメージ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeYoshinari en-aut-sei=Watanabe en-aut-mei=Yoshinari kn-aut-name=渡邊佳成 kn-aut-sei=渡邊 kn-aut-mei=佳成 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院社会文化科学研究科 END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue= article-no= start-page=15 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=出現するほとけ―密教経企軌の記載を中心に en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SasakiMoritoshi en-aut-sei=Sasaki en-aut-mei=Moritoshi kn-aut-name=佐々木守俊 kn-aut-sei=佐々木 kn-aut-mei=守俊 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院社会文化科学研究科 END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=3 article-no= start-page=205 end-page=211 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201606 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Structure of a New Palatal Plate and the Artificial Tongue for Articulation Disorder in a Patient with Subtotal Glossectomy en-subtitle= kn-subtitle= en-abstract= kn-abstract=A palatal augmentation prosthesis (PAP) is used to facilitate improvement in the speech and swallowing functions of patients with tongue resection or tongue movement disorders. However, a PAPʼs effect is limited in cases where articulation disorder is severe due to wide glossectomy and/or segmental mandibulectomy. In this paper, we describe speech outcomes of a patient with an articulation disorder following glossectomy and segmental mandibulectomy. We used a palatal plate (PP) based on a PAP, along with an artificial tongue (KAT). Speech improvement was evaluated by a standardized speech intelligibility test consisting of 100 syllables. The speech intelligibility score was significantly higher when the patient wore both the PP and KAT than when he wore neither (p＝0.013). The conversational intelligibility score was significantly improved with the PP and KAT than without PP and KAT (p＝0.024). These results suggest that speech function can be improved in patients with hard tissue defects with segmental mandibulectomy using both a PP and a KAT. The nature of the design of the PP and that of the KAT will allow these prostheses to address a wide range of tissue defects. en-copyright= kn-copyright= en-aut-name=KozakiKen-ichi en-aut-sei=Kozaki en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawakamiShigehisa en-aut-sei=Kawakami en-aut-mei=Shigehisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KonishiTakayuki en-aut-sei=Konishi en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhtaKeiji en-aut-sei=Ohta en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YanoJitsuro en-aut-sei=Yano en-aut-mei=Jitsuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OnodaTomoo en-aut-sei=Onoda en-aut-mei=Tomoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatsumotoHiroshi en-aut-sei=Matsumoto en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MizukawaNobuyoshi en-aut-sei=Mizukawa en-aut-mei=Nobuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NishizakiKazunori en-aut-sei=Nishizaki en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IidaSeiji en-aut-sei=Iida en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=GofukuAkio en-aut-sei=Gofuku en-aut-mei=Akio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=AbeMasanobu en-aut-sei=Abe en-aut-mei=Masanobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MinagiShogo en-aut-sei=Minagi en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=Okayama Dream Speech Project en-aut-sei=Okayama Dream Speech Project en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil=Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Division of Physical Medicine and Rehabilitation, Okayama University Hospital kn-affil= affil-num=4 en-affil=Dental Laboratory Division, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Otolaryngology-Head and Neck Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Otolaryngology-Head and Neck Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=13 en-affil=Department of Computer Science, Okayama University kn-affil= affil-num=14 en-affil=Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil= kn-affil= en-keyword=palatal augmentation prosthesis kn-keyword=palatal augmentation prosthesis en-keyword=artificial tongue kn-keyword=artificial tongue en-keyword=articulation disorder kn-keyword=articulation disorder en-keyword=glossectomy kn-keyword=glossectomy en-keyword=mandibulectomy kn-keyword=mandibulectomy END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=球面自己組織化マップを用いたマイクロアレイデータ解析による細胞表面マーカーの同定 kn-title=Identification of cell surface markers from multidimensional microarray data utilizing spherical Self Organizing Maps en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SugiiYu en-aut-sei=Sugii en-aut-mei=Yu kn-aut-name=杉井裕 kn-aut-sei=杉井 kn-aut-mei=裕 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=好中球エラスターゼ阻害薬は体外肺灌流システム中の肺機能を改善する kn-title=A neutrophil elastase inhibitor improves lung function during ex vivo lung perfusion en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HaradaMasaki en-aut-sei=Harada en-aut-mei=Masaki kn-aut-name=原田昌明 kn-aut-sei=原田 kn-aut-mei=昌明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒアルロン酸はIL-1β産生およびこれによるNF-κBの活性化を阻害することにより、ヒト軟骨細胞においてメカニカルストレスにより誘導される異化酵素の発現を抑制する kn-title=Hyaluronan suppresses mechanical stress-induced expression of catabolic enzymes by human chondrocytes via inhibition of IL-1β production and subsequent NF-κB activation en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OzawaMasatsugu en-aut-sei=Ozawa en-aut-mei=Masatsugu kn-aut-name=小澤正嗣 kn-aut-sei=小澤 kn-aut-mei=正嗣 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=2 article-no= start-page=91 end-page=94 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150803 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 2014 Incentive Award of the Okayama Medical Association in Cancer Research (2014 Hayashibara Prize and Yamada Prize) kn-title=平成26年度岡山医学会賞 がん研究奨励賞（林原賞・山田賞） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YanoShuya en-aut-sei=Yano en-aut-mei=Shuya kn-aut-name=矢野修也 kn-aut-sei=矢野 kn-aut-mei=修也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=22-2 cd-vols= no-issue= article-no= start-page=27 end-page=72 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=旅行記・戦記に見る「ミャンマー（ビルマ）」の風景　-18世紀後半～19世紀前半のイギリス人の記述を中心として- en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeYoshinari en-aut-sei=Watanabe en-aut-mei=Yoshinari kn-aut-name=渡邊佳成 kn-aut-sei=渡邊 kn-aut-mei=佳成 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=1 article-no= start-page=25 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laparoscopic total colectomy with lymph node dissection for familial adenomatous polyposis with multiple colorectal cancers kn-title=家族性大腸腺腫症（FAP）に合併した同時性５多発大腸癌に対してリンパ節郭清を伴う腹腔鏡下大腸全摘術を施行した１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 49-year-old Japanese man visited our hospital with chief complaints of difficulty with and bleeding during defecation. After a detailed examination, he was diagnosed with familial adenomatous polyposis (FAP) with multiple (five) colorectal cancers. The tumors were located in the right-sided, left-sided, and sigmoid colon, and the lower rectum. Regional lymph node involvement was observed, but no metastasis to other organs was detected. We, therefore, performed a laparoscopic total colectomy with superior mesenteric artery (SMA) and inferior mesenteric artery (IMA) lymph node dissection. We were able to perform minimally invasive and cosmetically acceptable surgery using laparoscopy instead of highly-invasive open abdominal surgery. Our search of the literature revealed no reported cases of laparoscopic total colectomy with lymph node dissection for FAP with multiple colorectal cancers, making the present case the first to be reported in the literature. en-copyright= kn-copyright= en-aut-name=KatoHiroshi en-aut-sei=Kato en-aut-mei=Hiroshi kn-aut-name=加藤大 kn-aut-sei=加藤 kn-aut-mei=大 aut-affil-num=1 ORCID= en-aut-name=OishiMasahiro en-aut-sei=Oishi en-aut-mei=Masahiro kn-aut-name=大石正博 kn-aut-sei=大石 kn-aut-mei=正博 aut-affil-num=2 ORCID= en-aut-name=KoderaMasahito en-aut-sei=Kodera en-aut-mei=Masahito kn-aut-name=小寺正人 kn-aut-sei=小寺 kn-aut-mei=正人 aut-affil-num=3 ORCID= en-aut-name=YamamuraMasao en-aut-sei=Yamamura en-aut-mei=Masao kn-aut-name=山村方夫 kn-aut-sei=山村 kn-aut-mei=方夫 aut-affil-num=4 ORCID= en-aut-name=IkedaHideaki en-aut-sei=Ikeda en-aut-mei=Hideaki kn-aut-name=池田秀明 kn-aut-sei=池田 kn-aut-mei=秀明 aut-affil-num=5 ORCID= en-aut-name=MizunoKenji en-aut-sei=Mizuno en-aut-mei=Kenji kn-aut-name=水野憲治 kn-aut-sei=水野 kn-aut-mei=憲治 aut-affil-num=6 ORCID= en-aut-name=YamashitaYutaka en-aut-sei=Yamashita en-aut-mei=Yutaka kn-aut-name=山下裕 kn-aut-sei=山下 kn-aut-mei=裕 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=鳥取市立病院　外科 affil-num=2 en-affil= kn-affil=鳥取市立病院　外科 affil-num=3 en-affil= kn-affil=鳥取市立病院　外科 affil-num=4 en-affil= kn-affil=鳥取市立病院　外科 affil-num=5 en-affil= kn-affil=鳥取市立病院　外科 affil-num=6 en-affil= kn-affil=鳥取市立病院　外科 affil-num=7 en-affil= kn-affil=鳥取市立病院　外科 en-keyword=家族性大腸腺腫症（FAP）（familial adenomatous polyposis） kn-keyword=家族性大腸腺腫症（FAP）（familial adenomatous polyposis） en-keyword=同時性多発大腸癌（synchronous colorectal cancer） kn-keyword=同時性多発大腸癌（synchronous colorectal cancer） en-keyword=大腸全摘術（colorectal surgery） kn-keyword=大腸全摘術（colorectal surgery） en-keyword=腹腔鏡下手術（laparoscopic surgery） kn-keyword=腹腔鏡下手術（laparoscopic surgery） END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=1 article-no= start-page=13 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Okayama University Survey of the current situation of community-based medical facilities supported by part-time work by physicians kn-title=岡山大学勤務医師による非常勤勤務を通した地域医療支援の現状調査 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　We investigated the situation of how physicians at Okayama University support local medical institutions by serving as a part-time worker, and analyzed the difference between the five medical districts of Okayama prefecture and other prefectures. Many physicians (actual number of physicians, full-time equivalent number of physicians) served in the southeastern region of the Okayama prefecture (339, 82.2). On the other hand, fewer physicians (42, 11.4) served in Takahashi・Niimi in the northwestern region of Okayama. Many physicians also served in Hiroshima prefecture (193, 48.8), Hyogo prefecture (109, 26.7), and the four prefectures of Shikoku Island (81, 23.6). 　It has been clarified that many physicians at Okayama University are working on a part-time basis to support local and community medical institutions in the wide area of Okayama prefecture, Hiroshima prefecture, Hyogo prefecture and the four prefectures of Shikoku Island. en-copyright= kn-copyright= en-aut-name=TeshigawaraSanae en-aut-sei=Teshigawara en-aut-mei=Sanae kn-aut-name=勅使川早苗 kn-aut-sei=勅使川 kn-aut-mei=早苗 aut-affil-num=1 ORCID= en-aut-name=IwaseToshihide en-aut-sei=Iwase en-aut-mei=Toshihide kn-aut-name=岩瀬敏秀 kn-aut-sei=岩瀬 kn-aut-mei=敏秀 aut-affil-num=2 ORCID= en-aut-name=KanamoriTatsuya en-aut-sei=Kanamori en-aut-mei=Tatsuya kn-aut-name=金森達也 kn-aut-sei=金森 kn-aut-mei=達也 aut-affil-num=3 ORCID= en-aut-name=KawabataTomoko en-aut-sei=Kawabata en-aut-mei=Tomoko kn-aut-name=川畑智子 kn-aut-sei=川畑 kn-aut-mei=智子 aut-affil-num=4 ORCID= en-aut-name=SatoMasaru en-aut-sei=Sato en-aut-mei=Masaru kn-aut-name=佐藤勝 kn-aut-sei=佐藤 kn-aut-mei=勝 aut-affil-num=5 ORCID= en-aut-name=Usui KataokaHitomi en-aut-sei=Usui Kataoka en-aut-mei=Hitomi kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 affil-num=2 en-affil= kn-affil=岡山県地域医療支援センター　岡山大学支部 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　地域医療人材育成 en-keyword=岡山大学勤務医師（physicians at Okayama University） kn-keyword=岡山大学勤務医師（physicians at Okayama University） en-keyword=非常勤勤務（part-time worker） kn-keyword=非常勤勤務（part-time worker） en-keyword=地域医療機関支援（community-based medical facilities） kn-keyword=地域医療機関支援（community-based medical facilities） END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=3 article-no= start-page=227 end-page=230 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20141201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Molecular target therapies in rheumatic diseases kn-title=リウマチ性疾患における分子標的治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WakabayashiHiroshi en-aut-sei=Wakabayashi en-aut-mei=Hiroshi kn-aut-name=若林宏 kn-aut-sei=若林 kn-aut-mei=宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 en-keyword=リウマチ性疾患 kn-keyword=リウマチ性疾患 en-keyword=自己免疫疾患 kn-keyword=自己免疫疾患 en-keyword=生物学的製剤 kn-keyword=生物学的製剤 en-keyword=分子標的薬 kn-keyword=分子標的薬 END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3 article-no= start-page=634 end-page=626 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080305 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Kaiyan Homi Kaikobad, Interpretation and Revision of International Boundary Decisions (Cambridge University Press, 2007, ⅩⅩvi + 364 pp.) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TamadaD. en-aut-sei=Tamada en-aut-mei=D. kn-aut-name=玉田大 kn-aut-sei=玉田 kn-aut-mei=大 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学社会文化科学研究科 END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=2 article-no= start-page=332 end-page=326 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Aïda Azar, L'exécution des décisions de la Cour internationale de justice (Bruylant, Université de Bruxelles, 2003, xx + 329 pp.) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TamadaD. en-aut-sei=Tamada en-aut-mei=D. kn-aut-name=玉田大 kn-aut-sei=玉田 kn-aut-mei=大 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学法学部 END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=1 article-no= start-page=190 end-page=181 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Leonardo Nemer Caldeira Brant, L'autorité de la chose jugée en droit international public (L.G.D.J., 2003, xi + 396 pp.) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TamadaD. en-aut-sei=Tamada en-aut-mei=D. kn-aut-name=玉田大 kn-aut-sei=玉田 kn-aut-mei=大 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学法学部 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=2 article-no= start-page=103 end-page=107 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B cell characteristics kn-title=十二指腸濾胞性リンパ腫はAIDの発現を欠くがBACH2の発現を有しmemoryB細胞としての性質を有する en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakataKatsuyoshi en-aut-sei=Takata en-aut-mei=Katsuyoshi kn-aut-name=高田尚良 kn-aut-sei=高田 kn-aut-mei=尚良 aut-affil-num=1 ORCID= en-aut-name=SatoYasuharu en-aut-sei=Sato en-aut-mei=Yasuharu kn-aut-name=佐藤康晴 kn-aut-sei=佐藤 kn-aut-mei=康晴 aut-affil-num=2 ORCID= en-aut-name=NakamuraNaoya en-aut-sei=Nakamura en-aut-mei=Naoya kn-aut-name=中村直哉 kn-aut-sei=中村 kn-aut-mei=直哉 aut-affil-num=3 ORCID= en-aut-name=TokunakaMami en-aut-sei=Tokunaka en-aut-mei=Mami kn-aut-name=徳中摩美 kn-aut-sei=徳中 kn-aut-mei=摩美 aut-affil-num=4 ORCID= en-aut-name=MikiYukari en-aut-sei=Miki en-aut-mei=Yukari kn-aut-name=三木由香里 kn-aut-sei=三木 kn-aut-mei=由香里 aut-affil-num=5 ORCID= en-aut-name=KikutiYara Yukie en-aut-sei=Kikuti en-aut-mei=Yara Yukie kn-aut-name=菊池イアーラ幸江 kn-aut-sei=菊池 kn-aut-mei=イアーラ幸江 aut-affil-num=6 ORCID= en-aut-name=IgarashiKazuhiko en-aut-sei=Igarashi en-aut-mei=Kazuhiko kn-aut-name=五十嵐和彦 kn-aut-sei=五十嵐 kn-aut-mei=和彦 aut-affil-num=7 ORCID= en-aut-name=ItoEtsuro en-aut-sei=Ito en-aut-mei=Etsuro kn-aut-name=伊藤悦郎 kn-aut-sei=伊藤 kn-aut-mei=悦郎 aut-affil-num=8 ORCID= en-aut-name=HarigaeHideo en-aut-sei=Harigae en-aut-mei=Hideo kn-aut-name=張替秀雄 kn-aut-sei=張替 kn-aut-mei=秀雄 aut-affil-num=9 ORCID= en-aut-name=KatoSeiichi en-aut-sei=Kato en-aut-mei=Seiichi kn-aut-name=加藤省一 kn-aut-sei=加藤 kn-aut-mei=省一 aut-affil-num=10 ORCID= en-aut-name=HayashiEiko en-aut-sei=Hayashi en-aut-mei=Eiko kn-aut-name=林詠子 kn-aut-sei=林 kn-aut-mei=詠子 aut-affil-num=11 ORCID= en-aut-name=OkaTakashi en-aut-sei=Oka en-aut-mei=Takashi kn-aut-name=岡剛史 kn-aut-sei=岡 kn-aut-mei=剛史 aut-affil-num=12 ORCID= en-aut-name=HoshiiYoshinobu en-aut-sei=Hoshii en-aut-mei=Yoshinobu kn-aut-name=星井嘉信 kn-aut-sei=星井 kn-aut-mei=嘉信 aut-affil-num=13 ORCID= en-aut-name=TariAkira en-aut-sei=Tari en-aut-mei=Akira kn-aut-name=田利晶 kn-aut-sei=田利 kn-aut-mei=晶 aut-affil-num=14 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=15 ORCID= en-aut-name=MohamadoABD Alkader Lamia en-aut-sei=Mohamado en-aut-mei=ABD Alkader Lamia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name=前田嘉信 kn-aut-sei=前田 kn-aut-mei=嘉信 aut-affil-num=17 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=18 ORCID= en-aut-name=KinoshitaTomohiro en-aut-sei=Kinoshita en-aut-mei=Tomohiro kn-aut-name=木下朝博 kn-aut-sei=木下 kn-aut-mei=朝博 aut-affil-num=19 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name=吉野正 kn-aut-sei=吉野 kn-aut-mei=正 aut-affil-num=20 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科病理学（腫瘍病理） affil-num=3 en-affil= kn-affil=東海大学医学部　病理診断学講座 affil-num=4 en-affil= kn-affil=東海大学医学部　病理診断学講座 affil-num=5 en-affil= kn-affil=香川保健医療短期大学 affil-num=6 en-affil= kn-affil=東海大学医学部　病理診断学講座 affil-num=7 en-affil= kn-affil=東北大学大学院医学系研究科 生物化学分野 affil-num=8 en-affil= kn-affil=弘前大学医学部　小児科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・免疫病学分野 affil-num=10 en-affil= kn-affil=名古屋大学病院　病理部 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） affil-num=13 en-affil= kn-affil=山口大学医学部　病理学 affil-num=14 en-affil= kn-affil=広島赤十字・原爆病院　消化器内科 affil-num=15 en-affil= kn-affil=岡山大学病院　光学診療部 affil-num=16 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） affil-num=17 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科血液・腫瘍・呼吸器内科学 affil-num=18 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科血液・腫瘍・呼吸器内科学 affil-num=19 en-affil= kn-affil=愛知がんセンター　血液細胞療法部 affil-num=20 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理学（腫瘍病理） en-keyword=follicular lymphoma kn-keyword=follicular lymphoma en-keyword=gastrointestinal tract kn-keyword=gastrointestinal tract en-keyword=BACH2 kn-keyword=BACH2 en-keyword=memory B cell kn-keyword=memory B cell END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=空気圧アクチュエータを用いた腰部パワーアシストウェアの開発 kn-title=Design of Wearable Power Assist Wear for Low Back Support Using Pneumatic Actuators en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=LiXiangpan en-aut-sei=Li en-aut-mei=Xiangpan kn-aut-name=李向攀 kn-aut-sei=李 kn-aut-mei=向攀 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=57 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lung cancer and molecular targeted drugs kn-title=肺癌と分子標的薬 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name=木浦勝行 kn-aut-sei=木浦 kn-aut-mei=勝行 aut-affil-num=1 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　呼吸器・アレルギー内科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 en-keyword=肺癌 kn-keyword=肺癌 en-keyword=分子プロファイリング kn-keyword=分子プロファイリング en-keyword=分子標的薬 kn-keyword=分子標的薬 en-keyword=EGFR遺伝子変異 kn-keyword=EGFR遺伝子変異 en-keyword=ALK融合遺伝子 kn-keyword=ALK融合遺伝子 END start-ver=1.4 cd-journal=joma no-vol=156 cd-vols= no-issue=1 article-no= start-page=20 end-page=28 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=201105 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comprehensive Sequence Analysis of 24,783 Barley Full-Length cDNAs Derived from 12 Clone Libraries en-subtitle= kn-subtitle= en-abstract= kn-abstract=Full-length cDNA (FLcDNA) libraries consisting of 172,000 clones were constructed from a two-row malting barley cultivar (Hordeum vulgare 'Haruna Nijo') under normal and stressed conditions. After sequencing the clones from both ends and clustering the sequences, a total of 24,783 complete sequences were produced. By removing duplicates between these and publicly available sequences, 22,651 representative sequences were obtained: 17,773 were novel barley FLcDNAs, and 1,699 were barley specific. Highly conserved genes were found in the barley FLcDNA sequences for 721 of 881 rice (Oryza sativa) trait genes with 50% or greater identity. These FLcDNA resources from our Haruna Nijo cDNA libraries and the full-length sequences of representative clones will improve our understanding of the biological functions of genes in barley, which is the cereal crop with the fourth highest production in the world, and will provide a powerful tool for annotating the barley genome sequences that will become available in the near future. en-copyright= kn-copyright= en-aut-name=MatsumotoTakashi en-aut-sei=Matsumoto en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaTsuyoshi en-aut-sei=Tanaka en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SakaiHiroaki en-aut-sei=Sakai en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AmanoNaoki en-aut-sei=Amano en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KanamoriHiroyuki en-aut-sei=Kanamori en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KuritaKanako en-aut-sei=Kurita en-aut-mei=Kanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KikutaAri en-aut-sei=Kikuta en-aut-mei=Ari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KamiyaKozue en-aut-sei=Kamiya en-aut-mei=Kozue kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamamotoMayu en-aut-sei=Yamamoto en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IkawaHiroshi en-aut-sei=Ikawa en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FujiiNobuyuki en-aut-sei=Fujii en-aut-mei=Nobuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=HoriKiyosumi en-aut-sei=Hori en-aut-mei=Kiyosumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=ItohTakeshi en-aut-sei=Itoh en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=SatoKazuhiro en-aut-sei=Sato en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=Natl Inst Agrobiol Sci affil-num=2 en-affil= kn-affil=Natl Inst Agrobiol Sci affil-num=3 en-affil= kn-affil=Natl Inst Agrobiol Sci affil-num=4 en-affil= kn-affil=Natl Inst Agrobiol Sci affil-num=5 en-affil= kn-affil=Inst Soc Techno Innovat Agr Forestry & Fisheries affil-num=6 en-affil= kn-affil=Inst Soc Techno Innovat Agr Forestry & Fisheries affil-num=7 en-affil= kn-affil=Inst Soc Techno Innovat Agr Forestry & Fisheries affil-num=8 en-affil= kn-affil=Inst Soc Techno Innovat Agr Forestry & Fisheries affil-num=9 en-affil= kn-affil=Inst Soc Techno Innovat Agr Forestry & Fisheries affil-num=10 en-affil= kn-affil=Inst Soc Techno Innovat Agr Forestry & Fisheries affil-num=11 en-affil= kn-affil=Hitachi Govt & Publ Corp Syst Engn Ltd affil-num=12 en-affil= kn-affil=Natl Inst Agrobiol Sci affil-num=13 en-affil= kn-affil=Natl Inst Agrobiol Sci affil-num=14 en-affil= kn-affil=Okayama Univ END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=3 article-no= start-page=265 end-page=267 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20121203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Medical care after catastrophic events kn-title=大規模災害における災害医療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=DoiHiroyuki en-aut-sei=Doi en-aut-mei=Hiroyuki kn-aut-name=土居弘幸 kn-aut-sei=土居 kn-aut-mei=弘幸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　疫学・衛生学 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=3 article-no= start-page=197 end-page=201 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20121203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by downregulating Th1 and Th17 kn-title=合成レチノイドAm80はTh1とTh17を抑制することにより慢性移植片対宿主病を改善する en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NishimoriHisakazu en-aut-sei=Nishimori en-aut-mei=Hisakazu kn-aut-name=西森久和 kn-aut-sei=西森 kn-aut-mei=久和 aut-affil-num=1 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name=前田嘉信 kn-aut-sei=前田 kn-aut-mei=嘉信 aut-affil-num=2 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 en-keyword=慢性移植片対宿主病 kn-keyword=慢性移植片対宿主病 en-keyword=同種造血幹細胞移植 kn-keyword=同種造血幹細胞移植 en-keyword=Th17細胞 kn-keyword=Th17細胞 en-keyword=Th1細胞 kn-keyword=Th1細胞 en-keyword=Am80 kn-keyword=Am80 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=2 article-no= start-page=167 end-page=173 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction (24. drug-drug interactions in intensive care unit) kn-title=薬物相互作用(24―ICUでの注意すべき薬物相互作用） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NishimiyaYusuke en-aut-sei=Nishimiya en-aut-mei=Yusuke kn-aut-name=西宮祐輔 kn-aut-sei=西宮 kn-aut-mei=祐輔 aut-affil-num=1 ORCID= en-aut-name=KonumaToshimitsu en-aut-sei=Konuma en-aut-mei=Toshimitsu kn-aut-name=小沼利光 kn-aut-sei=小沼 kn-aut-mei=利光 aut-affil-num=2 ORCID= en-aut-name=TasakaKen en-aut-sei=Tasaka en-aut-mei=Ken kn-aut-name=田坂健 kn-aut-sei=田坂 kn-aut-mei=健 aut-affil-num=3 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=2 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=3 en-affil= kn-affil=岡山大学病院　薬剤部 affil-num=4 en-affil= kn-affil=岡山大学病院　薬剤部 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=1 article-no= start-page=47 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical study of the prognostic factors in colorectal cancer patients with synchronous liver metastasis kn-title=当院における大腸癌同時性肝転移症例の臨床病理学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study was aimed to clarify the prognostic factors in colorectal cancer patients with synchronous liver metastasis. Fifty-four patients were assessed to evaluate prognoses according to various clinico-pathological factors and therapeutic procedures. The patients' survival was significantly related to extrahepatic distant metastasis and therapeutic procedures. Regarding therapeutic procedures, the liver resection group showed significantly improved survival compared with the chemotherapy group, especially in liver metastasis Grade B. For colorectal liver metastases, it is clear that liver resection is the most effective treatment at present. Further improvement of patient prognoses is expected to be achieved by future research on combination chemotherapy. en-copyright= kn-copyright= en-aut-name=MiyasouHideaki en-aut-sei=Miyasou en-aut-mei=Hideaki kn-aut-name=宮宗秀明 kn-aut-sei=宮宗 kn-aut-mei=秀明 aut-affil-num=1 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=岩川和秀 kn-aut-sei=岩川 kn-aut-mei=和秀 aut-affil-num=2 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=3 ORCID= en-aut-name=KimuraYuuji en-aut-sei=Kimura en-aut-mei=Yuuji kn-aut-name=木村祐司 kn-aut-sei=木村 kn-aut-mei=祐司 aut-affil-num=4 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=5 ORCID= en-aut-name=HamanoRyousuke en-aut-sei=Hamano en-aut-mei=Ryousuke kn-aut-name=濱野亮輔 kn-aut-sei=濱野 kn-aut-mei=亮輔 aut-affil-num=6 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=徳永尚之 kn-aut-sei=徳永 kn-aut-mei=尚之 aut-affil-num=7 ORCID= en-aut-name=TunemitsuYousuke en-aut-sei=Tunemitsu en-aut-mei=Yousuke kn-aut-name=常光洋輔 kn-aut-sei=常光 kn-aut-mei=洋輔 aut-affil-num=8 ORCID= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=大塚眞哉 kn-aut-sei=大塚 kn-aut-mei=眞哉 aut-affil-num=9 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=6 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=7 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=8 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=9 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=10 en-affil= kn-affil=国立病院機構福山医療センター　外科 en-keyword=大腸癌 (colorectal cancer) kn-keyword=大腸癌 (colorectal cancer) en-keyword=同時性肝転移 (synchronous liver metastasis) kn-keyword=同時性肝転移 (synchronous liver metastasis) en-keyword=肝切除 (liver resection) kn-keyword=肝切除 (liver resection) en-keyword=化学療法 (chemotherapy) kn-keyword=化学療法 (chemotherapy) END start-ver=1.4 cd-journal=joma no-vol=2005 cd-vols= no-issue=94 article-no= start-page=123 end-page=130 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Construction of Compositional Lexical Database Based on Lexical Conceptual Structure kn-title=分類の根拠を明示した動詞語彙概念構造辞書の構築 en-subtitle= kn-subtitle= en-abstract=This paper presents our ongoing research for constructing a Japanese verb lexicon which is founded on the theory of lexical conceptual structure (LCS). LCS provides a framework for capturing the relation between syntactic behaviors of lexical items and their semantic properties, which is useful for a range of NLP tasks including translation, paraphrasing and summarization. We discuss design issues involved in LCS dictionary development, and present an overview of the current specification of the lexicon, which is designed to allow successive future refinements. kn-abstract=本研究では語彙概念構造を利用した動詞の辞書データベースを構築する．語彙概念構造は構文上での語の振る舞いを基に意味構造を記述するもので，こうした辞書データは言語処理において特に言語生成，例えば翻訳や言い換え，要約といった応用に必須となる言語資源である．提案する辞書データは語彙概念構造のみを記述するのではなく，語彙概念構造の分析で明らかにする語の振る舞い，ならびに分析の基となる統語テストを記述するため，分類根拠がわかりやすく透明性の高い辞書データとなることが期待できる． en-copyright= kn-copyright= en-aut-name=TakeuchiKoichi en-aut-sei=Takeuchi en-aut-mei=Koichi kn-aut-name=竹内孔一 kn-aut-sei=竹内 kn-aut-mei=孔一 aut-affil-num=1 ORCID= en-aut-name=InuiKentaro en-aut-sei=Inui en-aut-mei=Kentaro kn-aut-name=乾健太郎 kn-aut-sei=乾 kn-aut-mei=健太郎 aut-affil-num=2 ORCID= en-aut-name=FujitaAtsushi en-aut-sei=Fujita en-aut-mei=Atsushi kn-aut-name=藤田篤 kn-aut-sei=藤田 kn-aut-mei=篤 aut-affil-num=3 ORCID= en-aut-name=TakeuchiNao en-aut-sei=Takeuchi en-aut-mei=Nao kn-aut-name=竹内奈央 kn-aut-sei=竹内 kn-aut-mei=奈央 aut-affil-num=4 ORCID= en-aut-name=AbeShuya en-aut-sei=Abe en-aut-mei=Shuya kn-aut-name=阿部修也 kn-aut-sei=阿部 kn-aut-mei=修也 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=2 en-affil= kn-affil=奈良先端科学技術大学院大学 affil-num=3 en-affil= kn-affil=京都大学情報学研究科 affil-num=4 en-affil= kn-affil= affil-num=5 en-affil= kn-affil=奈良先端科学技術大学院大学 END start-ver=1.4 cd-journal=joma no-vol=2006 cd-vols= no-issue=94 article-no= start-page=13 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Construction of rule-based model for semantic role labeling with the EDR thesaurus and an LCS dictionary kn-title=名詞の概念体系を利用した規則に基づく意味役割付与モデルの構築 en-subtitle= kn-subtitle= en-abstract=We present a rule-based model for semantic role labelingbecause semantic role labels should be assigned by means of metoric relationsips between mouns and vers. The purpose of this resarch is to reveal the this resarch is to reveal the restritional and preference rules between nouns and verbs. Our model uses the EDR thesaurus as semantics of nouns, and a lexical conceptual structure dictionary as verb semantics. Experimental results show that dealing with systemantic nominal categorization is the key to improve the accuracy of semantic role labeling. kn-abstract=本稿では名詞の概念体系辞書と述語のもつ語の概念構造を用いた規則ベースの意味役割付与モデルの構築を提案する．意味役割は名詞と述語との関係から決定されることから,本研究では述語の持つイベント構造と述語がとる名詞との間にどのようなメカニズムが存在するのかを明らかにすることを目標とする.新聞コーバスを対象とした評価実験から,名詞間の概念の類似度を正しく計ること,機能語の単位を正しく取り出すことが精度向上へのポイントであることが明らかになった． en-copyright= kn-copyright= en-aut-name=ShimomuraTakuya en-aut-sei=Shimomura en-aut-mei=Takuya kn-aut-name=下村拓也 kn-aut-sei=下村 kn-aut-mei=拓也 aut-affil-num=1 ORCID= en-aut-name=TakeuchiKoichi en-aut-sei=Takeuchi en-aut-mei=Koichi kn-aut-name=竹内孔一 kn-aut-sei=竹内 kn-aut-mei=孔一 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院自然科学研究科 END start-ver=1.4 cd-journal=joma no-vol=2006 cd-vols= no-issue=94 article-no= start-page=35 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Web Search Result Clustering Based on Structure of Compound Nouns kn-title=複合名詞に着目したWeb検索結果のクラスタリング en-subtitle= kn-subtitle= en-abstract=In this paper, we propose a aclustering method based on structure of compound nouns. Japanese compound nouns usually provide concrete concepts, thus we can assume that compound nouns must be a good clue to index documents for Web document clustering. The other benefit of using compound nouns is their compositional structure that can ve divided into sub concepts. This indicates that we can construct hierarchical Web document clustering based on their strcture. From the practical experiments of constructing hierarchical clusters on the results of a Web search engine, we succeeded in showing that the clearly lusterized web documents with understandable hierarchical indexes of compound nouns. kn-abstract=本稿では複合名詞に着目したWeb検索結果のクラスタリング手法を提案する．本手法では検索結果のタイトルと要約を利用し，階層的で一つの検索結果が複数のクラスタに含まれることを認めるクラスタリングを行う．本手法は次の２つの仮説に基づいている．1)複合名詞は固有の概念を表すため，文書を特徴付けやすい．2)複合名詞間の語構成関係を利用して，部分複合による類概念，および上位下位関係のクラスラベルを作成することで見通しの良いＷｅｂ文書の分類ができる．実験の結果，複合名詞の構造は分かりやすいクラスタ構造の形成に利用でき，また自然なラベル付けに有効であった．このことから，複合名詞は検索結果全体を見渡すためのよいインデックスであると言える． en-copyright= kn-copyright= en-aut-name=HiraoKazuki en-aut-sei=Hirao en-aut-mei=Kazuki kn-aut-name=平尾一樹 kn-aut-sei=平尾 kn-aut-mei=一樹 aut-affil-num=1 ORCID= en-aut-name=TakeuchiKoichi en-aut-sei=Takeuchi en-aut-mei=Koichi kn-aut-name=竹内孔一 kn-aut-sei=竹内 kn-aut-mei=孔一 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院自然科学研究科 affil-num=2 en-affil= kn-affil=岡山大学大学院自然科学研究科 END start-ver=1.4 cd-journal=joma no-vol=2008 cd-vols= no-issue=4 article-no= start-page=87 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080122 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An evaluation of document set similarity based on morpheme occurence patterns kn-title=用語クラスタリングに基づく部分研究領域推定と用語分類 en-subtitle= kn-subtitle= en-abstract=Term classification associate to research sub-domain is an important approach for systematized classification of term candidates extracted from text corpora. The authors have developed a method which identify some of the important research sub-domains in research abstract corpora. The authors also proved that relatively frequent term candidates extracted from the corpus can be related to identified sub-domains. kn-abstract=研究抄録テキストコーパスから抽出された用語候補を体系的に整理する一つの有力な方法として、部分研究領域に関連付けた用語の分類を考えることができる。本研究では、動詞概念との共起に基づく用語クラスタリングによって、特定研究分野のいくつかの部分研究領域が同定できることを示すとともに、同定された部分領域との関連により、テキストコーパスから抽出された用語候補の分類が可能であることを示す。 en-copyright= kn-copyright= en-aut-name=KoyamaTeruo en-aut-sei=Koyama en-aut-mei=Teruo kn-aut-name=小山照夫 kn-aut-sei=小山 kn-aut-mei=照夫 aut-affil-num=1 ORCID= en-aut-name=TakeuchiKoichi en-aut-sei=Takeuchi en-aut-mei=Koichi kn-aut-name=竹内孔一 kn-aut-sei=竹内 kn-aut-mei=孔一 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=国立情報学研究所 affil-num=2 en-affil= kn-affil=岡山大学大学院自然科学研究科 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=3 article-no= start-page=253 end-page=257 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Miki Commemorative Award in 2011 : An outline of my research and two big graduates of our medical school kn-title=私の研究概略と岡山大学医学部の２人の大先輩―2011年度三木記念賞を受賞して― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NambaMasayoshi en-aut-sei=Namba en-aut-mei=Masayoshi kn-aut-name=難波正義 kn-aut-sei=難波 kn-aut-mei=正義 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=新見公立大学，岡山医学振興会 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=3 article-no= start-page=231 end-page=235 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Japanese guidelines for the diagnosis and management of soft tissue tumor kn-title=軟部腫瘍診療ガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MorimotoYuki en-aut-sei=Morimoto en-aut-mei=Yuki kn-aut-name=森本裕樹 kn-aut-sei=森本 kn-aut-mei=裕樹 aut-affil-num=1 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name=尾﨑敏文 kn-aut-sei=尾﨑 kn-aut-mei=敏文 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　整形外科 affil-num=2 en-affil= kn-affil=岡山大学病院　整形外科 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=3 article-no= start-page=185 end-page=189 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20111201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Anti-HMGB1 mAb protects the blood-brain barrier from ischemia-induced disruption in rats kn-title=ラット中大脳動脈閉塞・再灌流モデルにおける抗HMGB1単クローン抗体の血液―脳関門の保護効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ZhangJiyong en-aut-sei=Zhang en-aut-mei=Jiyong kn-aut-name=張継勇 kn-aut-sei=張 kn-aut-mei=継勇 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　薬理学 en-keyword=脳梗塞 kn-keyword=脳梗塞 en-keyword=血液脳関門 kn-keyword=血液脳関門 en-keyword=炎症 kn-keyword=炎症 en-keyword=HMGB1 kn-keyword=HMGB1 en-keyword=抗体医薬 kn-keyword=抗体医薬 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=91 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A long-term follow-up study of Dravet syndrome up to adulthood kn-title=成人期に達したDravet症候群の長期経過に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AkiyamaMari en-aut-sei=Akiyama en-aut-mei=Mari kn-aut-name=秋山麻里 kn-aut-sei=秋山 kn-aut-mei=麻里 aut-affil-num=1 ORCID= en-aut-name=KobayashiKatsuhiro en-aut-sei=Kobayashi en-aut-mei=Katsuhiro kn-aut-name=小林勝弘 kn-aut-sei=小林 kn-aut-mei=勝弘 aut-affil-num=2 ORCID= en-aut-name=YoshinagaHarumi en-aut-sei=Yoshinaga en-aut-mei=Harumi kn-aut-name=吉永治美 kn-aut-sei=吉永 kn-aut-mei=治美 aut-affil-num=3 ORCID= en-aut-name=OhtsukaYoko en-aut-sei=Ohtsuka en-aut-mei=Yoko kn-aut-name=大塚頌子 kn-aut-sei=大塚 kn-aut-mei=頌子 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　発達神経病態学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　発達神経病態学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　発達神経病態学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　発達神経病態学 en-keyword=Dravet症候群 kn-keyword=Dravet症候群 en-keyword=乳児重症ミオクロニーてんかん kn-keyword=乳児重症ミオクロニーてんかん en-keyword=予後 kn-keyword=予後 en-keyword=けいれん性てんかん重積状態 kn-keyword=けいれん性てんかん重積状態 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=2 article-no= start-page=143 end-page=149 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=201104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=For Vol. 64, No. 1 pp 27-31 Prognostic Factors Influencing Survival after ephroureterectomy for Transitional Cell Carcinoma of the Upper Urinary Tract en-subtitle= kn-subtitle= en-abstract= kn-abstract=We analyzed the prognostic factors influencing survival after surgeries for upper urinary tract urothelial carcinoma (UUT-UC) with longer follow-up periods than in previous studies. Between January 2000 and December 2004, 386 patients underwent nephroureterectomy for UUT-UC. The data for the 221 patients with UUT-UC were retrospectively reviewed. Nine variables were evaluated for association with the survival outcomes of cause-specific survival. The prognostic significance was tested univariately with the log-rank test. The simultaneous effects of multiple prognostic factors were estimated by multiple regression analysis using the Cox proportional hazards model. The median follow-up was 38.4 months. The 5-year over all survival was 62.3%. Significant prognostic factors for disease-specific survival rate on univariate analysis were pathological stage (p0.0001), tumor grade (p0.0324), and venous invasion (p0.0001). Multivariate analysis revealed that only venous invasion was significant for disease-specific survival rate (p0.0205). Venous invasion was the only independent prognostic factor in pathologically localized UUT-UC. en-copyright= kn-copyright= en-aut-name=KobayashiYasuyuki en-aut-sei=Kobayashi en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SaikaTakashi en-aut-sei=Saika en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ManabeDaisuke en-aut-sei=Manabe en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NasuYasutomo en-aut-sei=Nasu en-aut-mei=Yasutomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KumonHiromi en-aut-sei=Kumon en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=nephroureterectomy kn-keyword=nephroureterectomy en-keyword=transitional cell carcinoma kn-keyword=transitional cell carcinoma en-keyword=upper urinary tract kn-keyword=upper urinary tract END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue=3 article-no= start-page=227 end-page=234 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=19891130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hiroshi Nakamura, History of the Funds Flow Statement kn-title=中村　宏著 『資金計算史論』 森山書店，昭和61年（pp. v, 197.） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SatohMichimasa en-aut-sei=Satoh en-aut-mei=Michimasa kn-aut-name=佐藤倫正 kn-aut-sei=佐藤 kn-aut-mei=倫正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=4 article-no= start-page=215 end-page=230 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On "The Seto Ohashi Bridge and Regional Economic Environmental Problems" edited by Prof. C. Sakamoto and Prof. R. Nakamura kn-title=坂本忠次・中村良平編著 『瀬戸大橋と地域経済・環境問題』 （山陽新聞社刊．pp．239．1992年3月25日）―瀬戸大橋架橋の社会経済的影響に関する包括的な総括への接近― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HashimotoRyoichi en-aut-sei=Hashimoto en-aut-mei=Ryoichi kn-aut-name=橋本了一 kn-aut-sei=橋本 kn-aut-mei=了一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=四国学院大学 END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue=2 article-no= start-page=255 end-page=263 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960828 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Amos Golan, George Judge and Douglas Miller, MAXIMUM ENTROPY ECONOMETRICS : ROBUST ESTIMATION WITH LIMITED DATA John Wiley and Sons, Chichester, 1996, pp. xvi +307 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FujimotoToshimi en-aut-sei=Fujimoto en-aut-mei=Toshimi kn-aut-name=藤本利躬 kn-aut-sei=藤本 kn-aut-mei=利躬 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue=2 article-no= start-page=239 end-page=242 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960828 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Age of Urban Choice kn-title=中村良平　著 『いま都市が選ばれる―競争と連携の時代へ―』 （山陽新聞社） 1995年11月　pp．245 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HashimotoYoshizō en-aut-sei=Hashimoto en-aut-mei=Yoshizō kn-aut-name=橋本介三 kn-aut-sei=橋本 kn-aut-mei=介三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=3-4 article-no= start-page=435 end-page=452 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The cardiovascular system and catecholamine concentration in blood during simple deep hypothermia with high dose fentanyl kn-title=大量フェンタニールによる単純超低体温麻酔時の循環動態と血中カテコラミン濃度に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Six adult dogs were anesthetized by deep hypothermia with a combination high dose fentanyl and PGE1 (F group). The circulatory system and blood catecholamine concentration were determined. Another 6 adult dogs were anesthetized by deep hypothermia with a combination ether and PEG1 (E group) for a comparison with the F group. Before cooling under anesthesia, the PAP, PVRI and Pp/Ps showed a significant difference in the E group. During cooling, the MAP was 74% and 56% of the control values in the F and E groups, respectively and there were significant differences between the F and E groups. The peak dp/dt/IP was significantly different between the F and E groups at the lowest temperature (46% and 27% of the conrol values, respectively). The CI was 34% and 25% of control values at the lowest temperature in both groups. EP or NE did not significantly increase during cooling or rewarming in the F group. The EP had a tendency to increase during rewarming and NE significantly increased in comparison with the control values during cooling and warming in the E group. Combination anesthesia with high dose fentanyl and PGE1 inhibits the circulatory systems to a lesser degree, resulting in easier maintenance of the circulatory system. This combination system is also more stable than that with ether and PGE1 or with ether and TFP. en-copyright= kn-copyright= en-aut-name=WakeMikiko en-aut-sei=Wake en-aut-mei=Mikiko kn-aut-name=和気幹子 kn-aut-sei=和気 kn-aut-mei=幹子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部麻酔・蘇生学教室 en-keyword=大量フェンタニール kn-keyword=大量フェンタニール en-keyword=単純超低体温麻酔 kn-keyword=単純超低体温麻酔 en-keyword=循環動態 kn-keyword=循環動態 en-keyword=血中カテコラミン濃度 kn-keyword=血中カテコラミン濃度 END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=3 article-no= start-page=265 end-page=267 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Carotid artery stenosis kn-title=頸部頸動脈狭窄症 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkumaYu en-aut-sei=Okuma en-aut-mei=Yu kn-aut-name=大熊佑 kn-aut-sei=大熊 kn-aut-mei=佑 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科学 END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=2 article-no= start-page=189 end-page=194 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A clinicopathological study of distal bile duct carcinoma at Fukuyama Medical Center kn-title=当院における下部胆管癌手術症例の治療成績 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced 20 patients with distal bile duct carcinoma from May, 1997 to December, 2007. The male/female ratio was 11/9 and the average age was 69.6 years. The operative procedures were as follows：pancreaticoduodenectomy (PD), 9；pyrolus preserving pancreaticoduodenectomy (PPPD), 8；subtotal stomach preserving pancreaticoduodenectomy (SSPPD), 2 and hepatico-jejunostomy without resection, 1. We performed a clinicopathological study on 16 patients with distal bile duct carcinoma, excluding 3 operation-related deaths and 1 unresectable case. The cumulative survival rate was 70% at 3 years and 11% at 5 years. The 3-year survival rates at fStageⅡ, fStageⅣa and fStageⅣb were 100%, 80% and 0%, respectively. Log-rank analysis revealed that pathological pancreatic and duodenal invasion and curative resectability may be prognostic factors, while lymph node metastasis and perineural and stump invasion did not affect prognosis. Six recurrences in the 11 curative resection cases (54.5%) were observed；therefore, postoperative systemic chemotherapy is warranted to curtail recurrence in advanced distal bile duct carcinoma. en-copyright= kn-copyright= en-aut-name=HamanoRyosuke en-aut-sei=Hamano en-aut-mei=Ryosuke kn-aut-name=濱野亮輔 kn-aut-sei=濱野 kn-aut-mei=亮輔 aut-affil-num=1 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=2 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=3 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=徳永尚之 kn-aut-sei=徳永 kn-aut-mei=尚之 aut-affil-num=4 ORCID= en-aut-name=TsunemitsuYosuke en-aut-sei=Tsunemitsu en-aut-mei=Yosuke kn-aut-name=常光洋輔 kn-aut-sei=常光 kn-aut-mei=洋輔 aut-affil-num=5 ORCID= en-aut-name=OhtsukaShinya en-aut-sei=Ohtsuka en-aut-mei=Shinya kn-aut-name=大塚眞哉 kn-aut-sei=大塚 kn-aut-mei=眞哉 aut-affil-num=6 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=岩川和秀 kn-aut-sei=岩川 kn-aut-mei=和秀 aut-affil-num=7 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=8 ORCID= en-aut-name=SonobeHiroshi en-aut-sei=Sonobe en-aut-mei=Hiroshi kn-aut-name=園部宏 kn-aut-sei=園部 kn-aut-mei=宏 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=6 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=7 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=8 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=9 en-affil= kn-affil=中国中央病院　臨床検査科 en-keyword=下部胆管癌 (distal bile duct carcinoma) kn-keyword=下部胆管癌 (distal bile duct carcinoma) en-keyword=手術 (operation) kn-keyword=手術 (operation) en-keyword=予後規定因子 (independent prognostic factors) kn-keyword=予後規定因子 (independent prognostic factors) END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=2 article-no= start-page=107 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of fecal DNA methylation to detect gastrointestinal neoplasia kn-title=便中メチル化DNA検出による消化器がんスクリーニング：消化器がんを非侵襲的にスクリーニングすることは可能か？ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NagasakaTakeshi en-aut-sei=Nagasaka en-aut-mei=Takeshi kn-aut-name=永坂岳司 kn-aut-sei=永坂 kn-aut-mei=岳司 aut-affil-num=1 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=2 ORCID= en-aut-name=SunDong-Sheng en-aut-sei=Sun en-aut-mei=Dong-Sheng kn-aut-name=孫冬生 kn-aut-sei=孫 kn-aut-mei=冬生 aut-affil-num=3 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=4 ORCID= en-aut-name=MastubaraNagahide en-aut-sei=Mastubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=5 ORCID= en-aut-name=YagiTakahito en-aut-sei=Yagi en-aut-mei=Takahito kn-aut-name=八木孝仁 kn-aut-sei=八木 kn-aut-mei=孝仁 aut-affil-num=6 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬総合研究科　消化器・腫瘍外科学 affil-num=2 en-affil= kn-affil=鳥取市立病院 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬総合研究科　消化器・腫瘍外科学 affil-num=4 en-affil= kn-affil=川崎医科大学附属病院　外科 affil-num=5 en-affil= kn-affil=兵庫医科大学　外科 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬総合研究科　消化器・腫瘍外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬総合研究科　消化器・腫瘍外科学 en-keyword=methylation kn-keyword=methylation en-keyword=stool kn-keyword=stool en-keyword=colorectal cancer kn-keyword=colorectal cancer en-keyword=gastric cancer kn-keyword=gastric cancer en-keyword=screening kn-keyword=screening END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=4 article-no= start-page=1111 end-page=1114 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evidence for new beta 1-3 galactosyltransferase activity involved in biosynthesis of unusual N-glycan harboring T-antigen in Apis mellifera en-subtitle= kn-subtitle= en-abstract= kn-abstract=In a previous study (Y. Kimura et al., Biosci. Biotechnol Biochem., 70, 2583-2587, 2006), we found that new complex type N-glycans harboring Thomsen-Friedenreich antigen (Ga1 beta 1-3GalNAc) unit occur on royal jelly glycoproteins, suggesting the involvement of a new beta 1-3galactosyltransferase in the synthesis of the unusual complex type N-glycans. So far, such beta 1-3galactosyltransferase activity, which can transfer galactosyl residues with the beta 1-3 linkage to beta 1-4 GalNAc residues in N-glycan, has not been found among any eucaryotic cells. But using GalNAc(2)GlcNAc(2)Man(3)-GlcNAc(2)-PA as acceptor N-glycan, we detected the beta 1-3 galactosyltransferase activity in membrane fraction prepared from honeybee cephalic portions. This result indicates that honeybee expresses a unique beta 1-3 galactosyltransferase involved in biosynthesis of the unusual N-glycan containing a tumor related antigen in the hypopharyngeal gland. en-copyright= kn-copyright= en-aut-name=KimuraYoshinobu en-aut-sei=Kimura en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakamuraSho en-aut-sei=Sakamura en-aut-mei=Sho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UshijimaTakayuki en-aut-sei=Ushijima en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HamaYoichiro en-aut-sei=Hama en-aut-mei=Yoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KajiuraHiroyuki en-aut-sei=Kajiura en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FujiyamaKazuhito en-aut-sei=Fujiyama en-aut-mei=Kazuhito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkiharaKiyoshi en-aut-sei=Okihara en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HashimotoKen en-aut-sei=Hashimoto en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SugimotoHiroyuki en-aut-sei=Sugimoto en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamadaHideo en-aut-sei=Yamada en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Department of Biofunctional Chemistry, Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Department of Applied Biological Sciences, Faculty of Agriculture, Saga University affil-num=5 en-affil= kn-affil=The International Center for Biotechnology, Osaka University affil-num=6 en-affil= kn-affil=The International Center for Biotechnology, Osaka University affil-num=7 en-affil= kn-affil=Yamada Apiculture Center, Inc. affil-num=8 en-affil= kn-affil=Yamada Apiculture Center, Inc. affil-num=9 en-affil= kn-affil=Yamada Apiculture Center, Inc. affil-num=10 en-affil= kn-affil=Yamada Apiculture Center, Inc. en-keyword=royal jelly glycoprotein; N-glycan kn-keyword=royal jelly glycoprotein; N-glycan en-keyword=Thomsen-Friedenreich antigen (Gal beta 1-3GalNAc) kn-keyword=Thomsen-Friedenreich antigen (Gal beta 1-3GalNAc) en-keyword=beta 1-3 galactosyltransferase kn-keyword=beta 1-3 galactosyltransferase en-keyword=Apis mellifera kn-keyword=Apis mellifera END start-ver=1.4 cd-journal=joma no-vol=366 cd-vols= no-issue=1 article-no= start-page=110 end-page=116 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Inhibition of tumor-stromal interaction through HGF/Met signaling by valproic acid en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hepatocyte growth factor (HGF), which is produced by surrounding stromal cells, including fibroblasts and endothelial cells, has been shown to be a significant factor responsible for cancer cell invasion mediated by tumor-stromal interactions. We found in this study that the anti-tumor agent valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, strongly inhibited tumor-stromal interaction. VPA inhibited HGF production in fibroblasts induced by epidermal growth factor (EGF), platelet-derived growth factor, basic fibroblast growth factor, phorbol 12-myristate 13-acetate (PMA) and prostaglandin E-2 without any appreciable cytotoxic effect. Other HDAC inhibitors, including butyric acid and trichostatin A (TSA), showed similar inhibitory effects on HGF production stimulated by various inducers. Up-regulations of HGF gene expression induced by PMA and EGF were also suppressed by VPA and TSA. Furthermore, VPA significantly inhibited HGF-induced invasion of HepG2 hepatocellular carcinoma cells. VPA, however, did not affect the increases in phosphorylation of MAPK and Akt in HGF-treated HepG2 cells. These results demonstrated that VPA inhibited two critical processes of tumor-stromal interaction, induction of fibroblastic HGF production and HGF-induced invasion of HepG2 cells, and suggest that those activities serve for other anti-tumor mechanisms of VPA besides causing proliferation arrest, differentiation, and/or apoptosis of tumor cells. en-copyright= kn-copyright= en-aut-name=MatsumotoYohsuke en-aut-sei=Matsumoto en-aut-mei=Yohsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MotokiTakahiro en-aut-sei=Motoki en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KubotaSatoshi en-aut-sei=Kubota en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakigawaMasaharu en-aut-sei=Takigawa en-aut-mei=Masaharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TsubouchiHirohito en-aut-sei=Tsubouchi en-aut-mei=Hirohito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=GohdaEiichi en-aut-sei=Gohda en-aut-mei=Eiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Immunochemistry, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Immunochemistry, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Biochemistry and Molecular Dentistry, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Digestive Disease and Life-style Related Disease, Health Research Human and Environmental Sciences, Kagoshima University, Graduate School of Medicine and Dental Sciences affil-num=6 en-affil= kn-affil=Department of Immunochemistry, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=hepatocyte growth factor kn-keyword=hepatocyte growth factor en-keyword=valproic acid kn-keyword=valproic acid en-keyword=histone deacetylase inhibitor kn-keyword=histone deacetylase inhibitor en-keyword=butyric acid kn-keyword=butyric acid en-keyword=trichostatin A kn-keyword=trichostatin A en-keyword=induction kn-keyword=induction en-keyword=tumor invasion kn-keyword=tumor invasion en-keyword=dermal fibroblast kn-keyword=dermal fibroblast END start-ver=1.4 cd-journal=joma no-vol=279 cd-vols= no-issue=3 article-no= start-page=303 end-page=312 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Modulation of defense signal transduction by flagellin-induced WRKY41 transcription factor in Arabidopsis thaliana en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Flagellin, a component of the flagellar filament of Pseudomonas syringae pv. tabaci 6605 (Pta), induces hypersensitive reaction in its non-host Arabidopsis thaliana. We identified the WRKY41 gene, which belongs to a multigene family encoding WRKY plant-specific transcription factors, as one of the flagellin-inducible genes in A. thaliana. Expression of WRKY41 is induced by inoculation with the incompatible pathogen P. syringae pv. tomato DC3000 (Pto) possessing AvrRpt2 and the non-host pathogens Pta within 6-h after inoculation, but not by inoculation with the compatible Pto. Expression of WRKY41 was also induced by inoculation of A. thaliana with an hrp-type three secretion system (T3SS)-defective mutant of Pto, indicating that effectors produced by T3SS in the Pto wild-type suppress the activation of WRKY41. Arabidopsis overexpressing WRKY41 showed enhanced resistance to the Pto wild-type but increased susceptibility to Erwinia carotovora EC1. WRKY41-overexpressing Arabidopsis constitutively expresses the PR5 gene, but suppresses the methyl jasmonate-induced PDF1.2 gene expression. These results demonstrate that WRKY41 may be a key regulator in the cross talk of salicylic acid and jasmonic acid pathways.

en-copyright= kn-copyright= en-aut-name=HigashiKuniaki en-aut-sei=Higashi en-aut-mei=Kuniaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IshigaYasuhiro en-aut-sei=Ishiga en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InagakiYoshishige en-aut-sei=Inagaki en-aut-mei=Yoshishige kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ToyodaKazuhiro en-aut-sei=Toyoda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShiraishiTomonori en-aut-sei=Shiraishi en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=6 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University en-keyword=flagellin kn-keyword=flagellin en-keyword=flg22 kn-keyword=flg22 en-keyword=FLS2 kn-keyword=FLS2 en-keyword=MAMP signaling pathway kn-keyword=MAMP signaling pathway en-keyword=WRKY41 kn-keyword=WRKY41 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=4 article-no= start-page=1086 end-page=1089 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Three antinematodal diterpenes from Euphorbia kansui en-subtitle= kn-subtitle= en-abstract= kn-abstract=Three compounds, 20-O-acetyl-[3-O-(2'E,4'Z)-deca-dienoyl]-ingenol (1), 20-O-acetyl-[5-O-(2'E,4'Z)-decadienoyl]-ingenol (2) and 3-O-(2'E,4'Z)-decadienoylingenol (3), were isolated from Euphorbia kansui under the bioassay-guided method. Each compound showed the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 mu g/cotton ball. en-copyright= kn-copyright= en-aut-name=ShiJian-Xiao en-aut-sei=Shi en-aut-mei=Jian-Xiao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=LiZhi-Xuan en-aut-sei=Li en-aut-mei=Zhi-Xuan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NitodaTeruhiko en-aut-sei=Nitoda en-aut-mei=Teruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IzumiMinoru en-aut-sei=Izumi en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KanzakiHiroshi en-aut-sei=Kanzaki en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=BabaNaomichi en-aut-sei=Baba en-aut-mei=Naomichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawazuKazuyoshi en-aut-sei=Kawazu en-aut-mei=Kazuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakajimaShuhei en-aut-sei=Nakajima en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=College of Life Science, Northwest University affil-num=2 en-affil= kn-affil=College of Life Science, Northwest University affil-num=3 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Department of Biofunctional Chemistry, Laboratory of Applied Natural Products Chemistry, Okayama University affil-num=4 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Department of Biofunctional Chemistry, Laboratory of Applied Natural Products Chemistry, Okayama University affil-num=5 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Department of Biofunctional Chemistry, Laboratory of Applied Natural Products Chemistry, Okayama University affil-num=6 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Department of Biofunctional Chemistry, Laboratory of Applied Natural Products Chemistry, Okayama University affil-num=7 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Department of Biofunctional Chemistry, Laboratory of Applied Natural Products Chemistry, Okayama University affil-num=8 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Department of Biofunctional Chemistry, Laboratory of Applied Natural Products Chemistry, Okayama University en-keyword=antinematodal activity kn-keyword=antinematodal activity en-keyword=Bursaphelenchus xylophilus kn-keyword=Bursaphelenchus xylophilus en-keyword=diterpenoid kn-keyword=diterpenoid en-keyword=ingenane kn-keyword=ingenane en-keyword=Euphorbia kansui kn-keyword=Euphorbia kansui END start-ver=1.4 cd-journal=joma no-vol=143 cd-vols= no-issue=4 article-no= start-page=467 end-page=473 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080626 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Selenite Assimilation into Formate Dehydrogenase H Depends on Thioredoxin Reductase in Escherichia coli en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Escherichia coli growing under anaerobic conditions produce H-2 and CO2 by the enzymatic cleavage of formate that is produced from pyruvate at the end of glycolysis. Selenium is an integral part of formate dehydrogenase H (FDHH), which catalyses the first step in the formate hydrogen lyase (FHL) system. The genes of FHL system are transcribed only under anaerobic conditions, in the presence of a sigma(54)-dependent transcriptional activator Fh1A that binds formate as an effector molecule. Although the formate addition to the nutrient media has been an established procedure for inducing high FDHH activity, we have identified a low-salt nutrient medium containing <0.1% NaCl enabled constitutive, high expression of FDHH even without formate and D-glucose added to the medium. The novel conditions allowed us to study the effects of disrupting genes like trxB (thioredoxin reductase) or gor (glutathione reductase) on the production of FDHH activity and also reductive assimilation of selenite (SeO32-) into the selenoprotein. Despite the widely accepted hypothesis that selenite is reduced by glutathione reductase-dependent system, it was demonstrated that trxB gene was essential for FDHH production and for labelling the FDHH polypeptide with Se-75-selenite. Our present study reports for the first time the physiological involvement of thioredoxin reductase in the reductive assimilation of selenite in E. coli.

en-copyright= kn-copyright= en-aut-name=TakahataMuneaki en-aut-sei=Takahata en-aut-mei=Muneaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TamuraTakashi en-aut-sei=Tamura en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AbeKatsumasa en-aut-sei=Abe en-aut-mei=Katsumasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiharaHisaaki en-aut-sei=Mihara en-aut-mei=Hisaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KurokawaSuguru en-aut-sei=Kurokawa en-aut-mei=Suguru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamamotoYoshihiro en-aut-sei=Yamamoto en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakanoRyuhei en-aut-sei=Nakano en-aut-mei=Ryuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=EsakiNobuyoshi en-aut-sei=Esaki en-aut-mei=Nobuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=InagakiKenji en-aut-sei=Inagaki en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Laboratory of Molecular Microbial Science, Institute for Chemical Research, Kyoto University affil-num=4 en-affil= kn-affil=Laboratory of Molecular Microbial Science, Institute for Chemical Research, Kyoto University affil-num=5 en-affil= kn-affil=Laboratory of Molecular Microbial Science, Institute for Chemical Research, Kyoto University affil-num=6 en-affil= kn-affil=Department of Genetics, Hyogo College of Medicine affil-num=7 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=8 en-affil= kn-affil=Department of Genetics, Hyogo College of Medicine affil-num=9 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University en-keyword=formate dehydrogenase H kn-keyword=formate dehydrogenase H en-keyword=selenite assimilation kn-keyword=selenite assimilation en-keyword=thioredoxin reductase kn-keyword=thioredoxin reductase END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=3 article-no= start-page=826 end-page=829 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200703 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Glucosylation of Sucrose Laurate with Cyclodextrin Glucanotransferase en-subtitle= kn-subtitle= en-abstract= kn-abstract=Sucrose monolauroyl esters were found to serve as substrates for cyclodextrin glucanotransferase (CGTase)-catalyzed transglucosidation reactions, affording new sucrose esters that have an additional 1-3 glucose residues on the pyranose ring of the sucrose moiety in the ester. en-copyright= kn-copyright= en-aut-name=OkadaKatsuhide en-aut-sei=Okada en-aut-mei=Katsuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ZhaoHaisuo en-aut-sei=Zhao en-aut-mei=Haisuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IzumiMinoru en-aut-sei=Izumi en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakajimaShuhei en-aut-sei=Nakajima en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=BabaNaomichi en-aut-sei=Baba en-aut-mei=Naomichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Research & Development Center, Hayashibara Biochemical Laboratories, Inc. affil-num=2 en-affil= kn-affil=Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Division of Bioscience, Graduate School of Natural Science and Technology, Okayama University en-keyword=cyclodextrin glucanotransferase kn-keyword=cyclodextrin glucanotransferase en-keyword=CGTase kn-keyword=CGTase en-keyword=sucrose monolaurate kn-keyword=sucrose monolaurate en-keyword=surfactant kn-keyword=surfactant END start-ver=1.4 cd-journal=joma no-vol=279 cd-vols= no-issue=4 article-no= start-page=313 end-page=322 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Gac two-component system in Pseudomonas syringae pv. tabaci is required for virulence but not for hypersensitive reaction en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Pseudomonas syringae pv. tabaci 6605 causes wildfire disease on host tobacco plants. To investigate the regulatory mechanism of the expression of virulence, Gac two-Component system-defective mutants, Delta gacA and Delta gacS, and a double mutant, Delta gacA Delta gacS, were generated. These mutants produced smaller amounts of N-acyl homoserine lactones required for quorum sensing, had lost swarming motility, and had reduced expression of virulence-related hrp genes and the algT gene required for exopolysaccharide production. The ability of the mutants to cause disease symptoms in their host tobacco plant was remarkably reduced, while they retained the ability to induce hypersensitive reaction (HR) in the nonhost plants. These results indicated that the Gac two-component system of P. syringae pv. tabaci 6605 is indispensable for virulence on the host plant, but not for HR induction in the nonhost plants.

en-copyright= kn-copyright= en-aut-name=MarutaniMizuri en-aut-sei=Marutani en-aut-mei=Mizuri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TaguchiFumiko en-aut-sei=Taguchi en-aut-mei=Fumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OgawaYujiro en-aut-sei=Ogawa en-aut-mei=Yujiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HossainMijan Md. en-aut-sei=Hossain en-aut-mei=Mijan Md. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YoshishigeInagaki en-aut-sei=Yoshishige en-aut-mei=Inagaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ToyodaKazuhiro en-aut-sei=Toyoda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShiraishiTomonori en-aut-sei=Shiraishi en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=6 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=7 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=8 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University en-keyword=GacA kn-keyword=GacA en-keyword=GacS kn-keyword=GacS en-keyword=Pseudomonas syringae pv. tabaci kn-keyword=Pseudomonas syringae pv. tabaci en-keyword=quorum sensing kn-keyword=quorum sensing en-keyword=two-component system kn-keyword=two-component system END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=24 article-no= start-page=8739 end-page=8747 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080706 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Drosophila blimp-1 is a transient transcriptional repressor that controls timing of the ecdysone-induced developmental pathway en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Regulatory mechanisms controlling the timing of developmental events are crucial for proper development to occur. ftz-fl is expressed in a temporally regulated manner following pulses of ecdysteroid and this precise expression is necessary for the development of Drosophila melanogaster. To understand how insect hormone ecdysteroids regulate the timing of FTZ-F1 expression, we purified a DNA binding regulator of ftz-fl. Mass spectroscopy analysis revealed this protein to be a fly homolog of mammalian B lymphocyte-induced maturation protein 1 (Blimp-1). Drosophila Blimp-1 (dBlimp-1) is induced directly by 20-hydroxyecdysone, and its product exists during high-ecdysteroid periods and turns over rapidly. Forced expression of dBlimp-1 and RNA interference analysis indicate that dBlimp-1 acts as a repressor and controls the timing of FTZ-F1 expression. Furthermore, its prolonged expression results in delay of pupation timing. These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway.

en-copyright= kn-copyright= en-aut-name=AgawaYasuo en-aut-sei=Agawa en-aut-mei=Yasuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SarhanMoustafa en-aut-sei=Sarhan en-aut-mei=Moustafa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KageyamaYuji en-aut-sei=Kageyama en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AkagiKazutaka en-aut-sei=Akagi en-aut-mei=Kazutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakaiMasayoshi en-aut-sei=Takai en-aut-mei=Masayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HashiyamaKazuya en-aut-sei=Hashiyama en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WadaTadashi en-aut-sei=Wada en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HandaHiroshi en-aut-sei=Handa en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IwamatsuAkihiro en-aut-sei=Iwamatsu en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HiroseSusumu en-aut-sei=Hirose en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=UedaHitoshi en-aut-sei=Ueda en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=Department of Developmental Genetics, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies affil-num=2 en-affil= kn-affil=The Graduate School of Natural Science and Technology and Department of Biology, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Developmental Genetics, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies affil-num=4 en-affil= kn-affil=The Graduate School of Natural Science and Technology and Department of Biology, Faculty of Science, Okayama University affil-num=5 en-affil= kn-affil=The Graduate School of Natural Science and Technology and Department of Biology, Faculty of Science, Okayama University affil-num=6 en-affil= kn-affil=Department of Developmental Genetics, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies affil-num=7 en-affil= kn-affil=Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology affil-num=8 en-affil= kn-affil=Integrated Research Institute, Tokyo Institute of Technology affil-num=9 en-affil= kn-affil=Protein Research Network, Inc. affil-num=10 en-affil= kn-affil=Department of Developmental Genetics, National Institute of Genetics and Department of Genetics, The Graduate University for Advanced Studies affil-num=11 en-affil= kn-affil=The Graduate School of Natural Science and Technology and Department of Biology, Faculty of Science, Okayama University en-keyword=SEQUENTIAL GENE ACTIVATION kn-keyword=SEQUENTIAL GENE ACTIVATION en-keyword=MATURATION PROTEIN-1 BLIMP-1 kn-keyword=MATURATION PROTEIN-1 BLIMP-1 en-keyword=STEROID-RECEPTOR SUPERFAMILY kn-keyword=STEROID-RECEPTOR SUPERFAMILY en-keyword=POLYTENE CHROMOSOMES kn-keyword=POLYTENE CHROMOSOMES en-keyword=SALIVARY-GLAND kn-keyword=SALIVARY-GLAND en-keyword=FUSHI-TARAZU kn-keyword=FUSHI-TARAZU en-keyword=EMBRYONIC-DEVELOPMENT kn-keyword=EMBRYONIC-DEVELOPMENT en-keyword=MOLECULAR-MECHANISM kn-keyword=MOLECULAR-MECHANISM en-keyword=TEMPORAL REGULATION kn-keyword=TEMPORAL REGULATION en-keyword=STAGE SPECIFICITY kn-keyword=STAGE SPECIFICITY END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=4 article-no= start-page=1078 end-page=1082 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of lipid derivatives of pyrrole polyamide and their biological activity en-subtitle= kn-subtitle= en-abstract= kn-abstract=Novel fatty acyl and phospholipid derivatives of pyrrole polyamide were synthesized. Their cytotoxicity against a cancer cell line of MT-4 cells and those infected by human immunodeficiency virus (HIV) was examined. Although no anti-HIV activity was found, their cytotoxicitty against the cancer cells was significantly enhanced by introducing a lipophilic group into the pyrrole polyamide. en-copyright= kn-copyright= en-aut-name=YamamotoMasahiko en-aut-sei=Yamamoto en-aut-mei=Masahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ZhuChangjin en-aut-sei=Zhu en-aut-mei=Changjin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YiLui en-aut-sei=Yi en-aut-mei=Lui kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=RongZheng en-aut-sei=Rong en-aut-mei=Zheng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiuraYoshie en-aut-sei=Miura en-aut-mei=Yoshie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IzumiMinoru en-aut-sei=Izumi en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakajimaShuhei en-aut-sei=Nakajima en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TanamotoKen-ichi en-aut-sei=Tanamoto en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ShimizuSakayu en-aut-sei=Shimizu en-aut-mei=Sakayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=BabaNaomichi en-aut-sei=Baba en-aut-mei=Naomichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=School of Chemical Engineering & Environment, Beijing Institute of Technology affil-num=3 en-affil= kn-affil=School of Chemical Engineering & Environment, Beijing Institute of Technology affil-num=4 en-affil= kn-affil=School of Chemical Engineering & Environment, Beijing Institute of Technology affil-num=5 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=6 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=7 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=8 en-affil= kn-affil=National Institute of Health Sciences, Division of Food Additives affil-num=9 en-affil= kn-affil=Department of Applied Bioscience, Graduate School of Agriculture, Kyoto University affil-num=10 en-affil= kn-affil=Department of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University en-keyword=pyrrole polyamide kn-keyword=pyrrole polyamide en-keyword=lipid kn-keyword=lipid en-keyword=phospholipid kn-keyword=phospholipid en-keyword=cancer cell kn-keyword=cancer cell en-keyword=human immunodeficiency virus (HIV)-II kn-keyword=human immunodeficiency virus (HIV)-II END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=3 article-no= start-page=134 end-page=139 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association of elevated plasma B-type natriuretic peptide levels with paroxysmal atrial fibrillation in patients with nonobstructive hypertrophic cardiomyopathy en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Objectives: To investigate the relationship between the plasma B-type natriuretic peptide (BNP) level and the occurrence of atrial fibrillation (AF) in nonobstructive hypertrophic cardiomyopathy (HCM) patients.
Methods: Patients (n=97) were classified into chronic AF (CAF; n=14), paroxysmal AF (PAF; n=18) and normal sinus rhythm (NSR; n=65) groups. The plasma BNP values were analyzed with logarithmic transformation.
Results: The PAF group showed significantly higher plasma BNP levels than the NSR group [mean (range; -1 SD and +1 SD); 248.3 (143.5, 429.5) vs. 78.2 (27.9, 218.8 ng/L), p<0.0001]. The CAF group also showed significantly higher plasma BNP levels than the NSR group [291.1 (161.4, 524.8 ng/L), p<0.0001]. Multivariate analysis with other clinical factors selected association of PAF as one of the factors that increased the plasma BNP level.
Conclusions: The present study indicated that plasma BNP level is clinically useful for identification of nonobstructive HCM patients who have a risk of PAF.

en-copyright= kn-copyright= en-aut-name=MatsuuraHiroko en-aut-sei=Matsuura en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MurakamiTakashi en-aut-sei=Murakami en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HinaKazuyoshi en-aut-sei=Hina en-aut-mei=Kazuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamamotoKeizo en-aut-sei=Yamamoto en-aut-mei=Keizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawamuraHiroshi en-aut-sei=Kawamura en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SogoTaiji en-aut-sei=Sogo en-aut-mei=Taiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShinohataRyoko en-aut-sei=Shinohata en-aut-mei=Ryoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=UsuiShinichi en-aut-sei=Usui en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NinomiyaYoshifumi en-aut-sei=Ninomiya en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KusachiShozo en-aut-sei=Kusachi en-aut-mei=Shozo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Cardiology, Cardiovascular Center, Sakakibara Hospital affil-num=3 en-affil= kn-affil=Department of Cardiology, Cardiovascular Center, Sakakibara Hospital affil-num=4 en-affil= kn-affil=Department of Cardiology, Cardiovascular Center, Sakakibara Hospital affil-num=5 en-affil= kn-affil=Department of Cardiology, Cardiovascular Center, Sakakibara Hospital affil-num=6 en-affil= kn-affil=Department of Cardiovascular Medicine, Takamatsu Red Cross Hospital affil-num=7 en-affil= kn-affil=Department of Medical Technology, Okayama University Graduate School of Health Sciences affil-num=8 en-affil= kn-affil=Department of Medical Technology, Okayama University Graduate School of Health Sciences affil-num=9 en-affil= kn-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=10 en-affil= kn-affil=Department of Medical Technology, Okayama University Graduate School of Health Sciences en-keyword=clinical study kn-keyword=clinical study en-keyword=cardiomyopathy kn-keyword=cardiomyopathy en-keyword=tachyarrhythmia kn-keyword=tachyarrhythmia en-keyword=enzyme immunoassay kn-keyword=enzyme immunoassay en-keyword=peptide kn-keyword=peptide en-keyword=sensitivity and specificity kn-keyword=sensitivity and specificity END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=3 article-no= start-page=427 end-page=429 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080622 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Immunological factors have been involved in the pathogenesis of dilated cardiomyopathy (DCM). The cytotoxic action of macrophages is one of the main factors causing cardiac myocyte damage. Monocyte chemoattractant protein-1 (MCP-1) is a major signal for the accumulation of monocytes/macrophages. We examined whether MCP-1 was expressed in the myocardium of DCM patients and whether the expression level was correlated with the degree of impairment of cardiac function. The expression of MCP-1 in the myocardium was determined by immunohistochemistry in endomyocardial biopsy samples from 13 patients. The expression of MCP-1 was found in all myocardial samples from DCM patients but not in those from control subjects. Positive staining for MCP-1 was distinct in cardiac myocytes, interstitium and infiltrating cells. Semi-quantitative analysis revealed that the expression of MCP-1 was inversely correlated with left ventricular ejection fraction. In conclusion, the expression level of MCP-1 in the myocardium was correlated with the degree of impairment of cardiac function in patients with DCM.

en-copyright= kn-copyright= en-aut-name=KobayashiMakoto en-aut-sei=Kobayashi en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakamuraKazufumi en-aut-sei=Nakamura en-aut-mei=Kazufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KusanoKengo Fukushima en-aut-sei=Kusano en-aut-mei=Kengo Fukushima kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakamuraYoichi en-aut-sei=Nakamura en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=Ohta-OgoKeiko en-aut-sei=Ohta-Ogo en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NagaseSatoshi en-aut-sei=Nagase en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SakuragiSatoru en-aut-sei=Sakuragi en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OheTohru en-aut-sei=Ohe en-aut-mei=Tohru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=aDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=aDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=cardiomyopathy kn-keyword=cardiomyopathy en-keyword=immunohistochemistry kn-keyword=immunohistochemistry en-keyword=monocyte kn-keyword=monocyte END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=5 article-no= start-page=648 end-page=652 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200805 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Radioactivity and radon emanation fraction of the granites sampled at Misasa and Badgastein en-subtitle= kn-subtitle= en-abstract= kn-abstract=The chemical composition was analyzed and the radioactivity, radon exhalation rate and emanation fraction were measured to investigate the characteristics of the granites sampled at Misasa and Badgastein, world famous for radon therapy. The Misasa granite was probably composed of quartz, albite and microcline. The Badgastein granite was probably composed of quartz and muscovite. The radon exhalation rates and emanation fractions of the Misasa granite were much higher than those of the Badgastein granite, regardless of the Ra-226 activity concentrations. en-copyright= kn-copyright= en-aut-name=SakodaAkihiro en-aut-sei=Sakoda en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HanamotoKatsumi en-aut-sei=Hanamoto en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IshimoriYu en-aut-sei=Ishimori en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NagamatsuTomohiro en-aut-sei=Nagamatsu en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamaokaKiyonori en-aut-sei=Yamaoka en-aut-mei=Kiyonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency affil-num=4 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University en-keyword=radioactivity kn-keyword=radioactivity en-keyword=radon emanation fraction kn-keyword=radon emanation fraction en-keyword=granite kn-keyword=granite en-keyword=Misasa kn-keyword=Misasa en-keyword=Badgastein kn-keyword=Badgastein END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=24 article-no= start-page=5800 end-page=5807 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080623 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=RhCl3/amine-catalyzed [2+2+2] cyclization of alkynes en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The RhCl3-3H(2)O/i-Pr2NEt-catalyzed [2+2+2] cyclotrimerization of alkynes has been achieved. The reaction can be widely used for various alkynes and provides tri- OF hexa-substituted benzenes regioselectively in high yields. The [2+2+2] cycloaddition of diynes and alkynes is also developed, and it affords benzene derivatives in moderate to high yields.

en-copyright= kn-copyright= en-aut-name=YoshidaKenta en-aut-sei=Yoshida en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MorimotoIchiro en-aut-sei=Morimoto en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MitsudoKoichi en-aut-sei=Mitsudo en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaHideo en-aut-sei=Tanaka en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, affil-num=2 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University en-keyword=Rh/amine catalyst kn-keyword=Rh/amine catalyst en-keyword=cyclotrimerization kn-keyword=cyclotrimerization en-keyword=hexa-substituted benzene kn-keyword=hexa-substituted benzene END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue=24 article-no= start-page=4167 end-page=4179 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis and regioselective N- and O-alkylation of 1H- or 3H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7(4H,6H)-diones (8-azaxanthines) and transformation of their 3-alkyl derivatives into 1-alkyl isomers en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Several alkylating agents, for example alkyl halides and dimethyl sulfate, were employed in aprotic Solvents Under a variety of conditions for the alkylation of mono- and disubstituted 1H- or 3H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7(4H,6H)-diones, which were prepared by cyclization of the appropriate 5,6-diaminouracils with nitrous acid. The alkylation on the triazole ring in the presence of anhydrous potassium carbonate took place simultaneously at the 1- and 2-positions, with alkylation at the 2-position taking priority. Similar alkylation on the pyrimidine ring with an equivalent alkylating reagent took place only at the 4-position. The alkylation of 3,6-disubstituted derivatives at room temperature led to 5-O-alkylation accompanied by 4-N-alkylation, but at high temperature only 4-N-alkylation took place. Reaction of 3,4,6-trisubstituted derivatives with excess alkylating agent at high temperature leads to the formation of 1,4,6-trisubstituted derivatives with elimination of the 3-substituent.

en-copyright= kn-copyright= en-aut-name=IslamRafiqul en-aut-sei=Islam en-aut-mei=Rafiqul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NagamatsuTomohisa en-aut-sei=Nagamatsu en-aut-mei=Tomohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Drug Discovery and Development, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry, and Pharmaceutica­l Sciences, Okayama University affil-num=2 en-affil= kn-affil=Department of Drug Discovery and Development, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry, and Pharmaceutica­l Sciences, Okayama University en-keyword=8-azaxanthines kn-keyword=8-azaxanthines en-keyword=triazolopyrimidines kn-keyword=triazolopyrimidines en-keyword=regioselectivity kn-keyword=regioselectivity en-keyword=alkylations kn-keyword=alkylations en-keyword=heterocycles kn-keyword=heterocycles END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=2 article-no= start-page=922 end-page=940 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Antitumor studies. Part 4: Design, synthesis, antitumor activity, and molecular docking study of novel 2-substituted 2-deoxoflavin-5-oxides, 2-deoxoalloxazine-5-oxides, and their 5-deaza analogs en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various novel 10-alkyl-2-deoxo-2-methylthioflavin-5-oxides and their 2-alkylamino derivatives were prepared by facile nitrosative cyclization of 6-(N-alkylanilino)-2-methylthiopyrimidin-4(3H)-ones followed by nucleophilic replacement of the 2-methylthio moiety by different amines, and acidic hydrolysis of the 2-methylthio moiety afforded the corresponding flavin derivatives. 2-Deoxo-2-methylthio-5-deazaalloxazines and 2-deoxo-2-methylthioalloxazine-5-oxides were also prepared by Vilsmeier reaction and by nitrosation of 6-anilino-2-methylthiopyrimidin-4(3H)-ones, respectively. Then, they were subjected to nucleophilic replacement with appropriate amines to produce the corresponding 2-alkylamino derivatives. Regiospecific N-3-alkylation of 2-deoxo-2-methylthioalloxazine-5-oxides was carried out with various alkylating agents in the usual way, The antitumor activities against CCRF-HSB-2 and KB tumor cells have been investigated in vitro, and many compounds showed promising antitumor activities. Furthermore, AutoDock molecular docking into PTK (PDB: 1t46) has been done for lead optimization of the aforementioned compounds as potential PTK inhibitors. en-copyright= kn-copyright= en-aut-name=AliHamed I. en-aut-sei=Ali en-aut-mei=Hamed I. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AshidaNoriyuki en-aut-sei=Ashida en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NagamatsuTomohisa en-aut-sei=Nagamatsu en-aut-mei=Tomohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Drug Discovery and Development, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Biology Laboratory, Research and Development Division, Yamasa Shoyu Co. affil-num=3 en-affil= kn-affil=Department of Drug Discovery and Development, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=antitumor activity kn-keyword=antitumor activity en-keyword=flavin-5-oxide kn-keyword=flavin-5-oxide en-keyword=alloxazine-5-oxide kn-keyword=alloxazine-5-oxide en-keyword=AutoDock kn-keyword=AutoDock END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue= article-no= start-page=3643 end-page=3647 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080619 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A cross-metathesis approach to the stereocontrolled synthesis of the AB ring segment of ciguatoxin en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Synthesis of the AB ring segments of ciguatoxin is described. The present synthesis includes a Lewis acid mediated cyclization of allylstannane with aldehyde, cross-metathesis reaction introducing the side chain, and Grieco-Nishizawa dehydration on the A ring.

en-copyright= kn-copyright= en-aut-name=KadotaIsao en-aut-sei=Kadota en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeTakashi en-aut-sei=Abe en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UniMiyuki en-aut-sei=Uni en-aut-mei=Miyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakamuraHiroyoshi en-aut-sei=Takamura en-aut-mei=Hiroyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamamotoYoshinori en-aut-sei=Yamamoto en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Graduate School of Science, Tohoku University affil-num=3 en-affil= kn-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Department of Chemistry, Graduate School of Science, Tohoku University en-keyword=POLYCYCLIC ETHERS kn-keyword=POLYCYCLIC ETHERS en-keyword=ABSOLUTE-CONFIGURATION kn-keyword=ABSOLUTE-CONFIGURATION en-keyword=HYDROXY GROUP kn-keyword=HYDROXY GROUP en-keyword=MOIETY kn-keyword=MOIETY en-keyword=FRAGMENT kn-keyword=FRAGMENT en-keyword=SYSTEM kn-keyword=SYSTEM en-keyword=ROUTE kn-keyword=ROUTE en-keyword=CTX3C kn-keyword=CTX3C END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=15 article-no= start-page=2363 end-page=2365 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Facile synthetic procedure for and electrochemical properties of hexa(2-thienyl)benzenes directed toward electroactive materials en-subtitle= kn-subtitle= en-abstract= kn-abstract=

In the presence of RhCl3 center dot 3H(2)O and i-Pr2NEt, the cyclotrimerization of di(2-thienyl)acetylenes proceeded smoothly to afford hexa(2-thienyl)benzenes. CV analysis of the hexa(2-thienyl)benzenes showed that they may be useful as electroactive materials.

en-copyright= kn-copyright= en-aut-name=YoshidaKenta en-aut-sei=Yoshida en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MorimotoIchiro en-aut-sei=Morimoto en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MitsudoKoichi en-aut-sei=Mitsudo en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TanakaHideo en-aut-sei=Tanaka en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University en-keyword=Rh/amine catalyst kn-keyword=Rh/amine catalyst en-keyword=cyclotrimerization kn-keyword=cyclotrimerization en-keyword=hexa(2-thienyl)benzene kn-keyword=hexa(2-thienyl)benzene en-keyword=electroactive material kn-keyword=electroactive material END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=242 end-page=256 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Antitumor studies. Part 1: Design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents en-subtitle= kn-subtitle= en-abstract= kn-abstract=Novel 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides were prepared as a new class of antitumor agents and showed significant antitumor activities against NCI-H 460, HCT 116, A 431, CCRF-HSB-2, and KB cell lines. In vivo investigation, 2-deoxo-10-methyl-2-phenyl-5-deazaflavin exhibited the effective antitumor activity against A 431 human adenocarcinoma cells transplanted subcutaneously into nude mouse. Furthermore, AutoDock study has been done by binding of the flavin analogs into PTK pp60(c-src), where a good correlation between their IC50 and AutoDock binding free energy was exhibited. In particular, 2-deoxo-2-phenylflavin-5-oxides exhibited the highest potential binding affinity within the binding pocket of PTK. en-copyright= kn-copyright= en-aut-name=AliHamed I.. en-aut-sei=Ali en-aut-mei=Hamed I.. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TomitaKeiichiro en-aut-sei=Tomita en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AkahoEiichi en-aut-sei=Akaho en-aut-mei=Eiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KambaraHiroto en-aut-sei=Kambara en-aut-mei=Hiroto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiuraShinji en-aut-sei=Miura en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HayakawaHiroyuki en-aut-sei=Hayakawa en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AshidaNoriyuki en-aut-sei=Ashida en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawashimaYutaka en-aut-sei=Kawashima en-aut-mei=Yutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamagishiTakehiro en-aut-sei=Yamagishi en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IkeyaHisao en-aut-sei=Ikeya en-aut-mei=Hisao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YonedaFumio en-aut-sei=Yoneda en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NagamatsuTomohisa en-aut-sei=Nagamatsu en-aut-mei=Tomohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=3 en-affil= kn-affil=Faculty of Pharmaceutical Sciences, High Technology Research Center (Life Science Center), and Center for Area Research and Development, Kobe Gakuin University affil-num=4 en-affil= kn-affil=Faculty of Pharmaceutical Sciences, High Technology Research Center (Life Science Center), and Center for Area Research and Development, Kobe Gakuin University affil-num=5 en-affil= kn-affil=Biology Laboratory, Research and Development Division, Yamasa Shoyu Co. affil-num=6 en-affil= kn-affil=Biology Laboratory, Research and Development Division, Yamasa Shoyu Co. affil-num=7 en-affil= kn-affil=Biology Laboratory, Research and Development Division, Yamasa Shoyu Co. affil-num=8 en-affil= kn-affil=Medicinal Research Laboratories, Taisho Pharmaceutical Co. affil-num=9 en-affil= kn-affil=Medicinal Research Laboratories, Taisho Pharmaceutical Co. affil-num=10 en-affil= kn-affil=Medicinal Research Laboratories, Taisho Pharmaceutical Co. affil-num=11 en-affil= kn-affil=Faculty of Pharmaceutical Sciences, Kyoto University affil-num=12 en-affil= kn-affil=Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=antitumor activity kn-keyword=antitumor activity en-keyword=Flavin analog kn-keyword=Flavin analog en-keyword=AutoDock kn-keyword=AutoDock en-keyword=protein tyrosine kinase kn-keyword=protein tyrosine kinase END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue= article-no= start-page=595 end-page=605 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080703 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=New dimeric flavans from gambir, an extract of Uncaria gambir en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Three new dimeric flavans, catechin-(4 alpha -> 8)-ent-epicatechin (7), gambirflavan D1 (8), and gambirflavan D2 (9), were isolated from gambir (an extract from the leaves and young twigs of Uncaria gambir), and their structures were determined based on spectroscopic and chemical data.

en-copyright= kn-copyright= en-aut-name=TaniguchiShoko en-aut-sei=Taniguchi en-aut-mei=Shoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KurodaKayo en-aut-sei=Kuroda en-aut-mei=Kayo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YoshikadoNaomi en-aut-sei=Yoshikado en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DoiKou-ichi en-aut-sei=Doi en-aut-mei=Kou-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanabeMasahiro en-aut-sei=Tanabe en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShibataTakashi en-aut-sei=Shibata en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YoshidaTakashi en-aut-sei=Yoshida en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HatanoTsutomu en-aut-sei=Hatano en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=2 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=3 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=4 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=5 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=6 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=7 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University affil-num=8 en-affil= kn-affil=Faculty of Pharmaceutical Science, Okayama University en-keyword=PROCYANIDINS kn-keyword=PROCYANIDINS END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=19 article-no= start-page=6336 end-page=6352 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Antitumor studies. Part 3: Design, synthesis, antitumor activity, and molecular docking study of novel 2-methylthio-, 2-amino-, and 2-(N-substituted amino)-10-alkyl-2-deoxo-5-deazaflavins en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various novel 10-alkyl-2-deoxo-2-methylthio-5-deazaflavins have been synthesized by reaction of 6-(N-alkylanilino)-2-methylthiopyrimidin-4(3H)-ones with Vilsmeier reagent. The similar 2-(N-substituted amino) derivatives were prepared by nucleophilic replacement reaction of the 2-methylthio moiety by appropriate amines. The 2-oxo derivatives (i.e., 5-deazaflavins) were obtained by acidic hydrolysis of the 2-methylthio derivatives. The antitumor activities against CCRF-HSB-2 and KB cells and the antiviral activities against HSV-1 and HSV-2 have been investigated in vitro, and many compounds showed promising antitumor activities. Furthermore, AutoDock molecular docking into PTK has been done for lead optimization of these compounds as potential PTK inhibitors. Whereas, the designed 2-deoxo-5-deazaflavins connected with amino acids at the 2-position exhibited the good binding affinities into PTK with more hydrogen bonds. en-copyright= kn-copyright= en-aut-name=AliHamed I. en-aut-sei=Ali en-aut-mei=Hamed I. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AshidaNoriyuki en-aut-sei=Ashida en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NagamatsuTomohisa en-aut-sei=Nagamatsu en-aut-mei=Tomohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Drug Discovery and Development, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Biology Laboratory, Research and Development Division, Yamasa Shoyu Co. affil-num=3 en-affil= kn-affil=aDepartment of Drug Discovery and Development, Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=antitumor activity kn-keyword=antitumor activity en-keyword=5-deazaflavin kn-keyword=5-deazaflavin en-keyword=AutoDock kn-keyword=AutoDock en-keyword=protein tyrosine kn-keyword=protein tyrosine en-keyword=kinase kn-keyword=kinase END start-ver=1.4 cd-journal=joma no-vol=149 cd-vols= no-issue=6 article-no= start-page=2816 end-page=2825 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080625 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Aldosterone breakthrough caused by chronic blockage of angiotensin II type 1 receptors in human adrenocortical cells: Possible involvement of bone morphogenetic protein-6 actions en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Circulating aldosterone concentrations occasionally increase after initial suppression with angiotensin II (Ang II) converting enzyme inhibitors or Ang II type 1 receptor blockers (ARBs), a phenomenon referred to as aldosterone breakthrough. However, the underlying mechanism causing the aldosterone breakthrough remains unknown. Here we investigated whether aldosterone breakthrough occurs in human adrenocortical H295R cells in vitro. We recently reported that bone morphogenetic protein (BMP)-6, which is expressed in adrenocortical cells, enhances Ang II-but not potassium-induced aldosterone production in human adrenocortical cells. Accordingly, we examined the roles of BMP-6 in aldosterone breakthrough induced by long-term treatment with ARB. Ang II stimulated aldosterone production by adrenocortical cells. This Ang II stimulation was blocked by an ARB, candesartan. Interestingly, the candesartan effects on Ang II-induced aldosterone synthesis and CYP11B2 expression were attenuated in a course of candesartan treatment for 15 d. The impairment of candesartan effects on Ang II-induced aldosterone production was also observed in Ang II- or candesartanpretreated cells. Levels of Ang II type 1 receptor mRNA were not changed by chronic candesartan treatment. However, BMP-6 enhancement of Ang II- induced ERK1/2 signaling was resistant to candesartan. The BMP-6-induced Smad1, -5, and -8 phosphorylation, and BRE-Luc activity was augmented in the presence of Ang II and candesartan in the chronic phase. Chronic Ang II exposure decreased cellular expression levels of BMP-6 and its receptors activin receptor-like kinase-2 and activin type II receptor mRNAs. Cotreatment with candesartan reversed the inhibitory effects of Ang II on the expression levels of these mRNAs. The breakthrough phenomenon was attenuated by neutralization of endogenous BMP-6 and activin receptor-like kinase-2. Collectively, these data suggest that changes in BMP-6 availability and response may be involved in the occurrence of cellular escape from aldosterone suppression under chronic treatment with ARB.

en-copyright= kn-copyright= en-aut-name=OtaniHiroyuki en-aut-sei=Otani en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InagakiKenichi en-aut-sei=Inagaki en-aut-mei=Kenichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SuzukiJiro en-aut-sei=Suzuki en-aut-mei=Jiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyoshiTomoko en-aut-sei=Miyoshi en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KanoYoshihiro en-aut-sei=Kano en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=GotoJunko en-aut-sei=Goto en-aut-mei=Junko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OguraToshio en-aut-sei=Ogura en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences affil-num=9 en-affil= kn-affil=Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences en-keyword=ENZYME-INHIBITOR THERAPY kn-keyword=ENZYME-INHIBITOR THERAPY en-keyword=CHRONIC HEART-FAILURE kn-keyword=CHRONIC HEART-FAILURE en-keyword=CONVERTING ENZYME kn-keyword=CONVERTING ENZYME en-keyword=HYPERTENSIVE PATIENTS kn-keyword=HYPERTENSIVE PATIENTS en-keyword=PLASMA-ALDOSTERONE kn-keyword=PLASMA-ALDOSTERONE en-keyword=GRANULOSA-CELLS kn-keyword=GRANULOSA-CELLS en-keyword=SYSTEM kn-keyword=SYSTEM en-keyword=SECRETION kn-keyword=SECRETION en-keyword=NEPHROPATHY kn-keyword=NEPHROPATHY en-keyword=HYPERTROPHY kn-keyword=HYPERTROPHY END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=8 article-no= start-page=2120 end-page=2124 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=200907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The use of graphite oxide to produce mesoporous carbon supporting Pt, Ru, or Pd nanoparticles en-subtitle= kn-subtitle= en-abstract= kn-abstract=Mesoporous carbon having platinum, ruthenium or palladium nanoparticles on exfoliated graphene sheets were produced from graphite oxide (GO) and metal complexes. The Pt included carbon was made by heating of the intercalation compound including tetraammineplatinum (II) chloride monohydrate. Samples having Ru or Pd are producible by heating in nitrogen gas atmosphere using hexaammineruthenium (III) chloride or tetraamminepalladium (II) chloride monohydrate instead of Pt complex. The particle sizes of platinum, ruthenium, and palladium were, respectively, 1–3, 1–2, and 3–7 nm. The platinum- or palladium-containing sample showed catalytic activity for oxygen reduction. en-copyright= kn-copyright= en-aut-name=GotohKazuma en-aut-sei=Gotoh en-aut-mei=Kazuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawabataKoji en-aut-sei=Kawabata en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiiEiji en-aut-sei=Fujii en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MorishigeKunimitsu en-aut-sei=Morishige en-aut-mei=Kunimitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KinumotoTaro en-aut-sei=Kinumoto en-aut-mei=Taro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyazakiYuki en-aut-sei=Miyazaki en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IshidaHiroyuki en-aut-sei=Ishida en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Industrial Technology Center of Okayama Prefecture affil-num=3 en-affil= kn-affil=Industrial Technology Center of Okayama Prefecture affil-num=4 en-affil= kn-affil=Okayama University of Science affil-num=5 en-affil= kn-affil=Faculty of Engineering, Oita University affil-num=6 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=7 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University END start-ver=1.4 cd-journal=joma no-vol=456 cd-vols= no-issue=4 article-no= start-page=687 end-page=691 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080626 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Barley plasma membrane intrinsic proteins (PIP aquaporins) as water and CO2 transporters en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We identified barley aquaporins and demonstrated that one, HvPIP2;1, transports water and CO2. Regarding water homeostasis in plants, regulations of aquaporin expression were observed in many plants under several environmental stresses. Under salt stress, a number of plasma membrane-type aquaporins were down-regulated, which can prevent continuous dehydration resulting in cell death. The leaves of transgenic rice plants that expressed the largest amount of HvPIP2;1 showed a 40% increase in internal CO2 conductance compared with leaves of wild-type rice plants. The rate of CO2 assimilation also increased in the transgenic plants. The goal of our plant aquaporin research is to determine the key aquaporin species responsible for water and CO2 transport, and to improve plant water relations, stress tolerance, CO2 uptake or assimilation, and plant productivity via molecular breeding of aquaporins.

en-copyright= kn-copyright= en-aut-name=KatsuharaMaki en-aut-sei=Katsuhara en-aut-mei=Maki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HanbaYuko T. en-aut-sei=Hanba en-aut-mei=Yuko T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Research Institute for Bioresources, Okayama University affil-num=2 en-affil= kn-affil=Center for Bioresource Field Science, Kyoto Institute of Technology en-keyword=barley kn-keyword=barley en-keyword=CO2 kn-keyword=CO2 en-keyword=plant aquaporins kn-keyword=plant aquaporins en-keyword=salt stress kn-keyword=salt stress en-keyword=water transport kn-keyword=water transport END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=3 article-no= start-page=508 end-page=513 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Induction of cytolytic activity and interferon-gamma production in murine natural killer cells by polymyxins B and E en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Natural killer (NK) cells are the primary effector cells of the innate immune system and have well-established roles in tumor rejection and resistance to viruses, bacteria and certain parasites. There is a need for more specific immune modulators of NK cell activity that tack the wide-ranging side effects of NK cell-stimulatory interleukins. The polycationic antibiotic polymyxin B (PMB) has been shown to have a unique ability to enhance activities of some immune cells, independent of its antibiotic properties. Here we report that both PMB and its analog potymyxin E (PME) markedly enhanced the activity of NK cells enriched from the murine spleen. Maximal activation of NK cell activity was obtained after 24 h of incubation with PMB at a dose of 300 mu g/ml. PMB nonapeptide, one of the two PMB domains, and PME methanesulfonate, the negatively charged derivative of PME, had little effect on NK cell activity. PMB induced interferon (IFN)-gamma and tumor necrosis factor-a production in NK cells. Proliferation of NK cells in vitro was significantly stimulated by being incubated with PMB. Administration of PMB to mice for 7 consecutive days stimulated splenic NK cell activity and increased NK cell populations in the spleen. These results suggest that the polycationic antibiotics PMB and PME may up-regulate innate and adaptive immune responses by induction of NK cell activity and IFN-gamma production.

en-copyright= kn-copyright= en-aut-name=ZhongMing en-aut-sei=Zhong en-aut-mei=Ming kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KadotaYusuke en-aut-sei=Kadota en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShimizuYoshio en-aut-sei=Shimizu en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GohdaEiichi en-aut-sei=Gohda en-aut-mei=Eiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Bizen Chemical Co., Ltd affil-num=4 en-affil= kn-affil=Department of Immunochemistry, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=polymyxin B (PMB) kn-keyword=polymyxin B (PMB) en-keyword=polymyxin E (PME) kn-keyword=polymyxin E (PME) en-keyword=NK cells kn-keyword=NK cells en-keyword=IFN-gamma kn-keyword=IFN-gamma END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=22 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20056 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Metallic phase in the metal-intercalated higher fullerene Rb8.8(7)C84 en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A new material of higher fullerene, RbxC84, was synthesized by intercalating Rb metal into C-84 crystals. The RbxC(84) crystals showed a simple cubic (sc) structure with lattice constant, a, of 16.82 (2) angstrom at 6.5 K, and 16.87 (2) angstrom at 295 K. The Rietveld refinements were achieved with the space group, Pa (3) over bar, based on a model that the C-2 axis of D2d-C84 aligned along [111]. The sample composition was determined to be Rb-8.8(7) C-84. The ESR spectrum at 303 K was composed of a broad peak with peak-to-peak linewidth Delta H-pp of 220 G, and a narrow peak with Delta H-pp of 24 G. Temperature dependence of the broad peak clearly showed a metallic behavior. The metallic behavior was discussed based on a theoretical calculation. This finding of new metallic phase in a higher fullerene is the first step for a development of new types of fullerene materials with novel physical properties such as superconductivity.

en-copyright= kn-copyright= en-aut-name=RikiishiYoshie en-aut-sei=Rikiishi en-aut-mei=Yoshie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KashinoYoko en-aut-sei=Kashino en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KusaiHaruka en-aut-sei=Kusai en-aut-mei=Haruka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakabayashiYasuhiro en-aut-sei=Takabayashi en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KuwaharaEiji en-aut-sei=Kuwahara en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KambeTakashi en-aut-sei=Kambe en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakenobuTaishi en-aut-sei=Takenobu en-aut-mei=Taishi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IwasaYoshihiro en-aut-sei=Iwasa en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MizorogiNaomi en-aut-sei=Mizorogi en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=NagaseShigeru en-aut-sei=Nagase en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=OkadaSusumu en-aut-sei=Okada en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=5 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=6 en-affil= kn-affil=Department of Chemistry, Okayama University affil-num=7 en-affil= kn-affil=Department of Physics, Okayama University affil-num=8 en-affil= kn-affil=CREST, Japan Science and Technology Agency affil-num=9 en-affil= kn-affil=CREST, Japan Science and Technology Agency affil-num=10 en-affil= kn-affil=Institute for Molecular Science affil-num=11 en-affil= kn-affil=Institute for Molecular Science affil-num=12 en-affil= kn-affil=Institute of Physics and Center for Computational Science, University of Tsukuba END start-ver=1.4 cd-journal=joma no-vol=401 cd-vols= no-issue= article-no= start-page=218 end-page=221 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Formation of low-resistivity region in p-Si substrate of SiGe/Si episystem by remote-hydrogen plasma treatment en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We have studied effects of hydrogen treatment on the resistivity profile of the SiGe/Si episystem by spreading resistance (SR) method. In this paper, we present experimental findings that hydrogen treatment reduces the resistivity at a specific part in the Si substrate region. This position was confirmed to be under the interface between SiGe and Si that emerged on the bevel surface during hydrogen treatment. We investigated the depth of resistivity-reduced regions which was formed by various hydrogenating conditions and found that the region was extended to the same depth as the penetration depth of hydrogen. We concluded that the low-resistivity region was formed under the influence of hydrogen introduced from bevel surface. We attributed this resistivity reduction to formation of some defects which originally existed at the interface and diffused into Si substrate with hydrogen.

en-copyright= kn-copyright= en-aut-name=YamashitaYoshifumi en-aut-sei=Yamashita en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakamotoYoshifumi en-aut-sei=Sakamoto en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KamiuraYoichi en-aut-sei=Kamiura en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IshiyamaTakeshi en-aut-sei=Ishiyama en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=The Graduate School of Natural Science and Technology, Okayama University en-keyword=SiGe/Si kn-keyword=SiGe/Si en-keyword=Hydroge. Resistivity reduction kn-keyword=Hydroge. Resistivity reduction en-keyword=Interface kn-keyword=Interface END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The evaluation of control measures against Schistosoma mekongi in Cambodia by a mathematical model en-subtitle= kn-subtitle= en-abstract= kn-abstract=

We constructed a mathematical model for the transmission of Schistosoma mekongi in Cambodia. The simulation of the model will be instrumental in planning schistosomiasis control measures. The model includes two definitive hosts, humans and dogs, as animal reservoirs. Dogs are recognized to play an important role in schistosomiasis transmission in Cambodia. For the purpose of dealing with age-specific prevalence and intensity of infection, the human population was classified into eight age categories in the model. To describe the seasonal fluctuation of the intermediate host population of S. mekongi, the "Post-Spate Survival" hypothesis was adopted for the population dynamics of Neotricula aperta present in the Mekong River. We carried out simulations to evaluate the effect of universal treatment (UT) and targeted mass treatment (TT) with praziquantel on the reduction in prevalence of S. mekongi. The simulations indicated that biyearly UT for 8 years or yearly TT for 5 years after three courses of yearly UT could reduce the prevalence to below 5% when a UT or TT coverage of 85% of inhabitants was achieved. The simulation suggested that the suppression of S. mekongi in Cambodia would be possible by UT or TT with a high coverage rate.

en-copyright= kn-copyright= en-aut-name=HisakaneNaoto en-aut-sei=Hisakane en-aut-mei=Naoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KirinokiMasashi en-aut-sei=Kirinoki en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ChigusaYuichi en-aut-sei=Chigusa en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SinuonMuth en-aut-sei=Sinuon en-aut-mei=Muth kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SocheatDuong en-aut-sei=Socheat en-aut-mei=Duong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsudaHajime en-aut-sei=Matsuda en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IshikawaHirofumi en-aut-sei=Ishikawa en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Human Ecology, Graduate School of Environmental Science, Okayama University affil-num=2 en-affil= kn-affil=Center for Tropical Medicine and Parasitology, Dokkyo Medical University School of Medicine affil-num=3 en-affil= kn-affil=Center for Tropical Medicine and Parasitology, Dokkyo Medical University School of Medicine affil-num=4 en-affil= kn-affil=National Center for Parasitology, Entomology and Malaria Control, Ministry of Health affil-num=5 en-affil= kn-affil=National Center for Parasitology, Entomology and Malaria Control, Ministry of Health affil-num=6 en-affil= kn-affil=Institute of International Education and Research, Dokkyo Medical University School of Medicine affil-num=7 en-affil= kn-affil=Department of Human Ecology, Graduate School of Environmental Science, Okayama University, en-keyword=Schistosoma mekongi kn-keyword=Schistosoma mekongi en-keyword=Cambodia kn-keyword=Cambodia en-keyword=mathematical model kn-keyword=mathematical model en-keyword=Neotricula aperta kn-keyword=Neotricula aperta en-keyword=Mekong River kn-keyword=Mekong River END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=4 article-no= start-page=281 end-page=285 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070705 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=N-terminal domain including conserved flg22 is required for flagellin-induced hypersensitive cell death in Arabidopsis thaliana en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Flagellin in Pseudomonas syringae is a potent elicitor of defense responses including hypersensitive cell death in dicot plants. The oligopeptides flg22 consisting of 22 conserved amino acids near the N-terminus of flagellins is reported to induce plant defense responses. Because glycosylation of the central domain of flagellin affects its elicitor activity, we investigated whether any peptide sequence in addition to flg22 is required for flagellin-induced hypersensitive reaction. A study of recombinant flagellin polypeptides indicated that the N-terminal domain including the conserved flg22 is required for flagellin-induced hypersensitive cell death in Arabidopsis thaliana.

en-copyright= kn-copyright= en-aut-name=KanaNaito en-aut-sei=Kana en-aut-mei=Naito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YasuhiroIshiga en-aut-sei=Yasuhiro en-aut-mei=Ishiga kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KazuhiroToyoda en-aut-sei=Kazuhiro en-aut-mei=Toyoda kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TomonoriShiraishi en-aut-sei=Tomonori en-aut-mei=Shiraishi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YukiIchinose en-aut-sei=Yuki en-aut-mei=Ichinose kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Laboratory of Plant Pathology and Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University en-keyword=Arabidopsis thaliana kn-keyword=Arabidopsis thaliana en-keyword=Flagellin kn-keyword=Flagellin en-keyword=Flg22 kn-keyword=Flg22 en-keyword=FLS2 kn-keyword=FLS2 en-keyword=HR cell death kn-keyword=HR cell death END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mathematical modeling of Echinococcus multilocularis transmission en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A mathematical model for the transmission cycle of Echinococcus multilocularis would be useful for estimating its prevalence, and the model simulation can be instrumental in designing various control strategies. This review focuses on the epidemiological factors in the E. multilocularis transmission cycle and the recent advances of mathematical models for E. multilocularis transmission.

en-copyright= kn-copyright= en-aut-name=IshikawaHirofumi en-aut-sei=Ishikawa en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University en-keyword=Echinococcus multilocularis kn-keyword=Echinococcus multilocularis en-keyword=fox kn-keyword=fox en-keyword=mathematical model kn-keyword=mathematical model en-keyword=vole kn-keyword=vole END start-ver=1.4 cd-journal=joma no-vol=18 cd-vols= no-issue=2 article-no= start-page=152 end-page=159 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Elicitin-responsive lectin-like receptor kinase genes in BY-2 cells en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The inhibition of elicitor-induced plant defense responses by the protein kinase inhibitors K252a and staurosporine indicates that defense responses require protein phosphorylation. We isolated a cDNA clone encoding Nicotiana tabacum lectin-like receptor protein kinase 1 ( NtlecRK1), an elicitor-responsive gene; in tobacco bright yellow ( BY-2) cells by a differential display method. NtlecRK forms a gene family with at least three members in tobacco. All three NtlecRK genes potentially encode the N-terminal legume lectin domain, transmembrane domain and C-terminal Ser/Thr-type protein kinase domain. Green fluorescent protein ( GFP) fusion showed that the NtlecRK1 protein was located on the plasma membrane. In addition, NtlecRK1 and 3 were responsive to INF1 elicitin and the bacterial elicitor harpin. These results indicate that NtlecRKs are membrane-located protein kinases that are induced during defense responses in BY-2 cells.

en-copyright= kn-copyright= en-aut-name=SasabeMichiko en-aut-sei=Sasabe en-aut-mei=Michiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NaitoKana en-aut-sei=Naito en-aut-mei=Kana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuenagaHiroko en-aut-sei=Suenaga en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IkedaTakako en-aut-sei=Ikeda en-aut-mei=Takako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ToyodaKazuhiro en-aut-sei=Toyoda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=InagakiYoshishige en-aut-sei=Inagaki en-aut-mei=Yoshishige kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShiraishiTomonori en-aut-sei=Shiraishi en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=3 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=6 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=7 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University affil-num=8 en-affil= kn-affil=Laboratory of Plant Pathology & Genetic Engineering, Graduate School of Natural Science and Technology, Okayama University en-keyword=defense response kn-keyword=defense response en-keyword=elicitin kn-keyword=elicitin en-keyword=lectin kn-keyword=lectin en-keyword=receptor-like kinase kn-keyword=receptor-like kinase en-keyword=tobacco BY-2 kn-keyword=tobacco BY-2 END start-ver=1.4 cd-journal=joma no-vol=190 cd-vols= no-issue=2 article-no= start-page=764 end-page=768 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of glycosylation on swimming ability and flagellar polymorphic transformation in Pseudomonas syringae pv. tabaci 6605 en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The role of flagellin glycosylation on motility was investigated in Pseudomonas syringae pv. tabaci. The swimming activity of glycosylation-defective mutants was prominently decreased in a highly viscous medium. The mutants showed differences in polymorphic transitions and in the bundle formation of flagella, indicating that glycosylation stabilizes the filament structure and lubricates the rotation of the bundle.

en-copyright= kn-copyright= en-aut-name=TaguchiFumiko en-aut-sei=Taguchi en-aut-mei=Fumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShibataSatoshi en-aut-sei=Shibata en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuzukiTomoko en-aut-sei=Suzuki en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OgawaYujiro en-aut-sei=Ogawa en-aut-mei=Yujiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AizawaShin-Ichi en-aut-sei=Aizawa en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakeuchiKasumi en-aut-sei=Takeuchi en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=2 en-affil= kn-affil=Department of Life Science, Prefectural University of Hiroshima affil-num=3 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University affil-num=5 en-affil= kn-affil=Department of Life Science, Prefectural University of Hiroshima affil-num=6 en-affil= kn-affil=National Institute of Agrobiological Sciences affil-num=7 en-affil= kn-affil=Graduate School of Natural Science and Technology, Okayama University END start-ver=1.4 cd-journal=joma no-vol=133 cd-vols= no-issue=2 article-no= start-page=538 end-page=542 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Analysis of response mechanism of a proton-pumping gate FET hydrogen gas sensor in air en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Two different types of hydrogen response signals (DC and AC) of a proton-pumping gate FET with triple layer gate structure (Pd/proton conducting polymer/Pt) were obtained. The proton-pumping gate FET showed good selectivity against other gases (CH4, C2H6, NH3, and O2). For practical use, the hydrogen response characteristics of the proton-pumping gate FET were investigated in air (a gaseous mixture of oxygen and nitrogen). The proton-pumping gate FET showed different hydrogen response characteristics in nitrogen as well as in air, despite the lack of oxygen interference independently. To clarify the response mechanism of the proton-pumping gate FET, a hydrogen response measurement was performed, using a gas flow system and electrochemical impedance spectroscopy. Consequently, the difference in response between nitrogen and air was found to be due to the hydrogen dissociation reaction and the interference with the proton transfer caused by the adsorbed oxygen on the upper Pd gate electrode

en-copyright= kn-copyright= en-aut-name=YamaguchiTomiharu en-aut-sei=Yamaguchi en-aut-mei=Tomiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakisawaMasanori en-aut-sei=Takisawa en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KiwaToshihiko en-aut-sei=Kiwa en-aut-mei=Toshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamadaHironobu en-aut-sei=Yamada en-aut-mei=Hironobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TsukadaKeiji en-aut-sei=Tsukada en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Department of Electrical and Electronic Engineering, Okayama University affil-num=4 en-affil= kn-affil=Department of Electrical and Electronic Engineering, Okayama University affil-num=5 en-affil= kn-affil=Department of Electrical and Electronic Engineering, Okayama University en-keyword=Field effect transistor (FET) kn-keyword=Field effect transistor (FET) en-keyword=Hydrogen sensor kn-keyword=Hydrogen sensor en-keyword=Proton-pumping gate kn-keyword=Proton-pumping gate en-keyword=Oxygen kn-keyword=Oxygen en-keyword=Electrochemical impedance spectroscopy (EIS) kn-keyword=Electrochemical impedance spectroscopy (EIS) END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue=2 article-no= start-page=185 end-page=189 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=195303 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Quelques Généralisations des Théorémes Concernant aux Produits Directs Des Espaces Linéaires Localement Convexes en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Les deux théorèmes, qui sont établis dans "Sur les espaces linéaires localement convexes" par O. Takenouchi (qui a paru dans ce même Journal, tom. 2, n°1, pp. 57-84), et qui insistent que le produit direct des espaces de chacune de deux espèces c.-à-d. "bornologique" et "tonnelé" est encore l'un de la même espèce, sont vrais sous les conditions moins restrictives. À savoir, Concernant au théorème 14: La restriction d'être complet n'est pas nécessaire. Concernant au théorème 15: La puissance d'ensemble des composants du produit peut être tenue encore plus grand.

en-copyright= kn-copyright= en-aut-name=AmemiyaIchiro en-aut-sei=Amemiya en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=3 article-no= start-page=951 end-page=956 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050811 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Kinetic-spectrophotometric method for the determination of trace amounts of bromide in seawater en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A novel simple, sensitive and rapid kinetic-spectrophotornetric method is proposed for the determination of trace amounts of bromide. The method is based on its catalytic effect on the oxidation of methylene blue (MB) by hydrogen peroxide in strongly acidic solution. The oxidation reaction is activated by large amounts of chloride and can be monitored spectrophotometrically by measuring the decrease in the absorbance of MB at 746 run. The determination of bromide is performed by a fixed-time method at the first 100 s from the initiation of the reaction. Unlike other kinetic-spectrophotornetric methods for the determination of bromide, the proposed method does not require heating the solution. Bromide can be determined in the range from 80 to 960 mu g l(-1) with the detection limit of 35 mu g l(-1). The relative standard deviation of ten replicate determination of 480 mu g l(-1) bromide was 1.4%. The influence of potential interfering ions was studied. The proposed method was satisfactorily applied to the determination of bromide in seawater without interfering effect from chloride ion.

en-copyright= kn-copyright= en-aut-name=UraisinKanchana en-aut-sei=Uraisin en-aut-mei=Kanchana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakayanagiToshio en-aut-sei=Takayanagi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=NacaprichaDuangjai en-aut-sei=Nacapricha en-aut-mei=Duangjai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Mahidol University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Kinetic-spectrophotometry kn-keyword=Kinetic-spectrophotometry en-keyword=Methylene blue kn-keyword=Methylene blue en-keyword=Bromide kn-keyword=Bromide en-keyword=Seawater kn-keyword=Seawater END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=2 article-no= start-page=388 end-page=393 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20051013 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=On-line preconcentration using dual mini-columns for the speciation of chromium(III) and chromium(VI) and its application to water samples as studied by inductively coupled plasma-atomic emission spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=

On-line preconcentration system for the selective, sensitive and simultaneous determination of chromium species was investigated. Dual minicolumns containing chelating resin were utilized for the speciation and preconcentration of Cr(III) and Cr(VI) in water samples. In this system, Cr(III) was collected on first column packed with iminodiacetate resin. Cr(VI) in the effluent from the first column was reduced to Cr(III), which was collected on the second column packed with iminodiacetate resin. Hydroxyammonium chloride was examined as a potential reducing agent for Cr(VI) to Cr(III). The effects of pH, sample flow rate, column length, and interfering ions on the recoveries of Cr(III) were carefully studied. Five millilitres of a sample solution was introduced into the system. The collected species were then sequentially washed by 1 M ammonium acetate, eluted by 2 M nitric acid and measured by ICP-AES. The detection limit for Cr(III) and Cr(VI) was 0.08 and 0.15 mu g l-1, respectively. The total analysis time was about 9.4 min. The developed method was successfully applied to the speciation of chromium in river, tap water and wastewater samples with satisfied results.

en-copyright= kn-copyright= en-aut-name=SumidaTakashi en-aut-sei=Sumida en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IkenoueTamami en-aut-sei=Ikenoue en-aut-mei=Tamami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HamadaKazuhide en-aut-sei=Hamada en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=5 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Industrial Technology Center of Kochi Prefecture affil-num=2 en-affil= kn-affil=Industrial Technology Center of Kochi Prefecture affil-num=3 en-affil= kn-affil=Industrial Technology Center of Kochi Prefecture affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=6 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=speciation kn-keyword=speciation en-keyword=chromium kn-keyword=chromium en-keyword=on-line preconcentration kn-keyword=on-line preconcentration en-keyword=ICP-AES kn-keyword=ICP-AES en-keyword=chelating resin kn-keyword=chelating resin END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=2 article-no= start-page=274 end-page=280 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Determination of trace amounts of bromide by flow injection/stopped-flow detection technique using kinetic-spectrophotometric method en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A simple, sensitive and selective method for the determination of bromide in seawater by using a flow injection/stopped-flow detection technique was examined. The detection system was developed for a new kinetic-spectrophotometric determination of bromide in the presence of chloride matrix without any extraction and/or separation. The detection was based on the kinetic effect of bromide on the oxidation of methylene blue (MB) with hydrogen peroxide in a strongly acidic solution. Large amounts of chloride could enhance the sensitivity of the method as an activator. The decolorisation of the blue color of MB was used for the spectrophotometric determination of bromide at 746 nm. A stopped-flow approach was used to improve the sensitivity of the measurement and provide good linearity of the calibration over the range of 0-3.2 p,g ml(-1) of bromide. The relative standard deviation was 0.74% for the determination of 2.4 jig ml(-1) bromide (n=5). The detection limit (3 sigma) was 0.1 mu g ml(-1) with a sampling frequency of 12 h(-1). The influence of potential interfering ions was studied. The proposed method was applied to the determination of bromide in seawater samples and provided satisfactory results.

en-copyright= kn-copyright= en-aut-name=UraisinK. en-aut-sei=Uraisin en-aut-mei=K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NacaprichaD. en-aut-sei=Nacapricha en-aut-mei=D. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=LapanantnoppakhunS. en-aut-sei=Lapanantnoppakhun en-aut-mei=S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GrudpanK. en-aut-sei=Grudpan en-aut-mei=K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Mahidol University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chiang Mai University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chiang Mai University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Stopped-flow injection kn-keyword=Stopped-flow injection en-keyword=Kinetic spectrophotometry kn-keyword=Kinetic spectrophotometry en-keyword=Methylene blue kn-keyword=Methylene blue en-keyword=Bromide kn-keyword=Bromide en-keyword=Seawater kn-keyword=Seawater END start-ver=1.4 cd-journal=joma no-vol=558 cd-vols= no-issue=1-2 article-no= start-page=246 end-page=253 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of a chitosan-based chelating resin and its application to the selective concentration and ultratrace determination of silver in environmental water samples en-subtitle= kn-subtitle= en-abstract= kn-abstract=A novel chelating resin using chitosan as a base material, ethylenediamine-type chitosan, has been synthesized for the first time in the present study, and applied to the collection/concentration of ultratrace amounts of silver in environmental water samples. In the present study, ultratrace amounts of silver collected on the resin were eluted and determined by ICP-MS. The resin packed in a 1 mL mini column could adsorb silver selectively and quantitatively at a flow rate of 2 mL min(-1) in the wide pH range from 1 to 8, and silver adsorbed on the resin could be easily recovered by passing 1 M nitric acid as an eluent into the column. High adsorption capacity for silver at pH 5, 0.37 mmol mL(-1) of the resin, was achieved, and t(1/2) of the adsorption is less than 5 min. The effect of chloride on the collection of silver was examined by varying chloride concentrations from 10(-4) to 0.75 M; the results showed that the present resin can be used for the collection/concentration of ultratrace amounts of silver in natural waters, as well as seawater. To ensure the accuracy and the precision of the method, CASS-4 near shore seawater reference material from the NRCC has been analyzed. This is not a certified SRM for silver, but has been used for comparative silver analysis by several groups, who report very similar results to those that are reported here. The developed method using ethylenediamine-type chitosan resin gives 0.7 pg mL(-1) of the detection limit when 50-fold enrichment was used. The proposed method was successfully applied to the determination of silver in tap, river, and seawater samples. en-copyright= kn-copyright= en-aut-name=KatarinaRosi Ketrin en-aut-sei=Katarina en-aut-mei=Rosi Ketrin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakayanagiToshio en-aut-sei=Takayanagi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Chelating resin kn-keyword=Chelating resin en-keyword=Chitosan kn-keyword=Chitosan en-keyword=Determination of silver kn-keyword=Determination of silver en-keyword=Environmental water samples kn-keyword=Environmental water samples en-keyword=ICP-MS kn-keyword=ICP-MS END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue=3 article-no= start-page=263 end-page=268 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200503 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Trace and ultratrace analysis of purified water samples and hydrogen peroxide solutions for phosphorus by flow-injection method en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A highly sensitive fluorescence-quenching method for the determination of phosphorus based on the formation of an ion associate between molybdophosphate and Rhodamine B (RB) was developed. A simple flow-injection system coupled with a fluorescence detector was used to measure the fluorescence intensity at 560 nm and 580 nm as an excitation and an emission wavelength, respectively. The calibration graph for phosphorus showed a good linearity in the range of (0-1) x 10(-7) M (1 M = 1 mol L-1), and a detection limit of I x 10(-9) M (SIN = 3). The proposed method was successfully applied to the determination of ultratrace amounts of phosphorus in ultrapurified and purified water samples, and to the determination of trace amounts of phosphorus in commercially-available hydrogen peroxide solutions with satisfactory results. en-copyright= kn-copyright= en-aut-name=LiZenhai en-aut-sei=Li en-aut-mei=Zenhai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=2 ORCID= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=6 article-no= start-page=1277 end-page=1285 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030829 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Novel flow injection-fluorometric method for the determination of trace silicate and its application to ultrapurified water analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A highly sensitive fluorescence quenching method for the determination of silicate based on the formation of an ion associate between molybdosilicate and Rhodamine B (RB) in nitric acid medium was developed. A flow injection system coupled with a fluorescence detector was used for the measurement of fluorescence intensity at 560 and 580 nm as excitation and emission wavelengths, respectively. The calibration graph for Si showed a linear range of 0.1-5 ng cm(-3) with correlation coefficient of 0.9999, and the detection limit of 0.06 ng cm(-3). The proposed method was successfully applied to the determination of silicate in ultrapurified water with satisfactory results.

en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=2 ORCID= en-aut-name=IshiiNaoe en-aut-sei=Ishii en-aut-mei=Naoe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Laboratory Water Division, Nihon Millipore Ltd affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=ultrapurified water kn-keyword=ultrapurified water en-keyword=ion associate kn-keyword=ion associate en-keyword=molybdosilicate kn-keyword=molybdosilicate en-keyword=rhodamine B kn-keyword=rhodamine B en-keyword=flow injection kn-keyword=flow injection en-keyword=fluorescence quenching kn-keyword=fluorescence quenching END start-ver=1.4 cd-journal=joma no-vol=581 cd-vols= no-issue=2 article-no= start-page=214 end-page=220 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070109 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Functionalization of chitosan with 3,4-dihydroxybenzoic acid for the adsorption/collection of uranium in water samples and its determination by inductively coupled plasma-mass spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=A chitosan resin derivatized with 3,4-dihydroxybenzoic acid moiety (CCTS-DHBA resin) was newly synthesized for the collection/concentration of trace uranium by using cross-linked chitosan (CCTS) as base material, and the adsorption behavior of uranium as well as 60 elements on the resin was examined by passing the sample solutions through a mini-column packed with the resin. After the elution of the collected elements on the resin with 1M HNO3, the eluates were measured by inductively coupled plasma-mass spectrometry (ICP-MS). The CCTS-DHBA resin can adsorb several metal cations and several oxoanionic elements at appropriate pH. Among these metal ions, uranium shows an excellent adsorption behavior on this resin. Uranium as UO22+ species can be adsorbed on the resin by chelating mechanism with adsorption capacity of 330 mg g(-1) resin. Through the column treatment, the complete removal of large amounts of alkali and alkaline earth matrices without any loss of adsorption efficiency over prolonged usage were achieved with this resin. The CCTS-DHBA resin was applied to the adsorption/collection of uranium in tap water, river water and seawater samples with satisfactory results. The validation of the proposed method was carried out by analyzing uranium in the standard reference materials of SLRS-4, CASS-4, and NASS-5 after passing through the CCTS-DHBA resin, and the results showed good agreement with the certified values. en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=2 ORCID= en-aut-name=TakayanagiToshio en-aut-sei=Takayanagi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HakimLukman en-aut-sei=Hakim en-aut-mei=Lukman kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=GaoYun Hua en-aut-sei=Gao en-aut-mei=Yun Hua kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=5 en-affil= kn-affil=Department of International Conservation Studies, Faculty of International and Industrial Studies, Kibi International University affil-num=6 en-affil= kn-affil=Technical Institute of Physics and Chemistry, Chinese Academy of Sciences affil-num=7 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Chitosan resin kn-keyword=Chitosan resin en-keyword=3,4-dihydroxybenzoic acid kn-keyword=3,4-dihydroxybenzoic acid en-keyword=Uranium kn-keyword=Uranium en-keyword=Adsorption kn-keyword=Adsorption en-keyword=Water kn-keyword=Water en-keyword=Inductively coupled plasma-mass spectrometry kn-keyword=Inductively coupled plasma-mass spectrometry END start-ver=1.4 cd-journal=joma no-vol=588 cd-vols= no-issue=1 article-no= start-page=73 end-page=81 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of novel chitosan resin derivatized with serine diacetic acid moiety and its application to on-line collection/concentration of trace elements and their determination using inductively coupled plasma-atomic emission spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=A novel chelating resin functionalized with serine diacetic acid moiety was synthesized by using chitosan as base material, and applied to the collection/concentration of trace elements in environmental water samples, followed by the determination using inductively coupled plasma-atomic emission spectrometer (ICP-AES). The synthesized resin, crosslinked chitosan serine diacetic acid (CCTS-SDA), showed good adsorption behavior toward trace amounts of Cd, Pb, Cu, Ni, V, Ga, Sc, In, and Th in a wide pH range. Additionally, rare earth elements also can be retained on the resin at neutral pH region. The adsorbed elements can be easily eluted with 1 mol L-1 of nitric acid, and their recoveries were found to be 90-100%. The CCTS-SDA was packed in a mini-column, which was then installed in a cornputer-controlled auto-pretreatment system (Auto-Pret System) for on-line trace elements collection and determination with ICP-AES. Experimental parameters which related to the improvement of sensitivity and reproducibility were optimized. The limits of detection (LOD) for 13 elements were found to be in sub-ppb level. The proposed method with CCTS-SDA resin was successfully applied to the determination of trace elements in river water samples. The method was validated by determining a certified reference material of river water, SLRS-4. en-copyright= kn-copyright= en-aut-name=LukmanHakim en-aut-sei=Lukman en-aut-mei=Hakim kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=chelating resin kn-keyword=chelating resin en-keyword=chitosan kn-keyword=chitosan en-keyword=serine diacetic acid moiety kn-keyword=serine diacetic acid moiety en-keyword=trace elements kn-keyword=trace elements en-keyword=on-line pretreatment kn-keyword=on-line pretreatment en-keyword=computer control kn-keyword=computer control en-keyword=inductively coupled plasma-atomic emission spectrometry kn-keyword=inductively coupled plasma-atomic emission spectrometry en-keyword=SLRS-4 kn-keyword=SLRS-4 END start-ver=1.4 cd-journal=joma no-vol=532 cd-vols= no-issue=1 article-no= start-page=27 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050507 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Slope comparison method (SCM) for the determination of trace amounts of silicate in ultrapurified water en-subtitle= kn-subtitle= en-abstract= kn-abstract=A sensitive analytical method for the determination of trace amounts of silicate in ultrapurified water was developed. The method is based on the formation of an ion associate of molybdosilicate with malachite green (MG) and the collection of the ion associate on a tiny membrane filter (diameter: 5 mm, and effective filtering diameter: 1 mm). The ion associate formed on the membrane filter is dissolved together with the membrane filter in 1 ml of methyl cellosolve (MC) and the absorbance of MC solution is measured at 627 nm by a flow injection-spectrophotometric detection technique. In this method, silicate in the original sample (ultrapurified water) is concentrated as the ion associate into a small volume of MC to get high sensitivity. As sample concentration takes place, the small amounts of silicate contained in the reagents used also become concentrated as the ion associate into MC. The original sample volumes are varied and evaporated to an identical volume. Therefore, the reagent added is fixed to the same volume. The absorbance increase linearly with increase in the original sample volume will be due only to silicate in the original samples (ultrapurified water). The resulting slopes obtained by varying the sample volumes are compared with the slope of the calibration graph, and thus named the slope comparison method (SCM). The SCM facilitates a more sensitive and accurate evaluation of silicate concentration in the samples than either common calibration method (CCM) or standard addition method (SAM) because it compensates for the influence of trace amounts of silicate contained in chemicals, reagent solution and solvent used. The calibration graph was constructed from 0 to 0.25 ng ml(-1) of Si and the detection limit was 10 pg ml(-1) (ppt) when 30 ml of samples was used. The standard deviation and relative standard deviation from six measurements of the reagent blanks were 0.0012 and 3.5%, respectively. en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=2 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=slope comparison method kn-keyword=slope comparison method en-keyword=ultrapurified water kn-keyword=ultrapurified water en-keyword=ion associate kn-keyword=ion associate en-keyword=molybdosilicate kn-keyword=molybdosilicate en-keyword=malachite green kn-keyword=malachite green en-keyword=membrane filter kn-keyword=membrane filter END start-ver=1.4 cd-journal=joma no-vol=542 cd-vols= no-issue=2 article-no= start-page=207 end-page=215 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of chitosan resin possessing 3,4-diamino benzoic acid moiety for the collection/concentration of arsenic and selenium in water samples and their measurement by inductively coupled plasma-mass spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=A chitosan resin functionalized with 3,4-diamino benzoic acid (CCTS-DBA resin) was newly synthesized by using a cross-linked chitosan (CCTS) as base material. The adsorption behavior of trace amounts of elements on the CCTS-DBA resin was examined by the pretreatment with a mini-column and measurement of the elements by inductively coupled plasma-Mass spectrometry (ICP-MS). Arsenic(V) could be retained on the CCTS-DBA resin at pH 3 as an oxoanion of H(2)ASO(4)(-). Selenium(VI) is strongly adsorbed at pH 2 and pH 3 as an oxoanion of SeO42-. while selenium(IV) as HSeO3- is adsorbed on the resin at pH 3. The sorption capacities are 82, 64, and 88 mg g(-1) resin for As(V), Se(IV), and Se(VI), respectively. The effect of common anions and cations on the adsorption of As(V), Se(IV), and Se(VI) were studied; there was no interference from such anionic matrices as chloride, sulfate, phosphate, and nitrate up to 20 ppm, as well as from such artificial river water matrices as Na, K, Mg, and Ca after passing samples through the mini-column containing the resin. The CCTS-DBA resin was applied to the collection of arsenic and selenium species in bottled drinking water, tap water, and river water. en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Cross-linked chitosan kn-keyword=Cross-linked chitosan en-keyword=3,4-diamino benzoic acid kn-keyword=3,4-diamino benzoic acid en-keyword=Arsenic kn-keyword=Arsenic en-keyword=Selenium kn-keyword=Selenium en-keyword=ICP-MS kn-keyword=ICP-MS END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5 article-no= start-page=1675 end-page=1680 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Flow-Injection Spectrofluorometric Determination of Trace Amounts of Formaldehyde in Water after Derivatization with Acetoacetanilide en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A novel fluorophotometric method for formaldehyde determination in environmental waters was developed: the method does not require any enrichment procedures. A flow-injection analysis method for the spectrofluorometric determination of formaldehyde in waters, which is based on the reaction of formaldehyde with acetoacetanilide and ammonia, is proposed. The proposed method shows a good linearity from 0.50 to 40 x 10(-7) M, and the limit of detection (LOD) of 3 x 10(-9) M (0.09 ppb) is achievable. The sample throughput is 15 h(-1). One of the main advantages in the proposed method is that the reaction can be carried out at room temperature without any heating system. The effect of various interferences possibly present in the real water samples was investigated. Most cations and anions, as well as organic compounds, do not interfere with the determination of formaldehyde in environmental water samples. The proposed method is very simple, rapid, less expensive, and highly sensitive, and can be applied to the environmental water samples, such as rain, tap water and river water, at low concentration levels without any enrichment procedure.

en-copyright= kn-copyright= en-aut-name=LiQiong en-aut-sei=Li en-aut-mei=Qiong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=2 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Spectrofluorometric kn-keyword=Spectrofluorometric en-keyword=Water samples kn-keyword=Water samples en-keyword=Flow-injection kn-keyword=Flow-injection en-keyword=Formaldehyde determination kn-keyword=Formaldehyde determination en-keyword=Acetoacetanilide kn-keyword=Acetoacetanilide END start-ver=1.4 cd-journal=joma no-vol=579 cd-vols= no-issue=1 article-no= start-page=33 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20061002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A membraneless gas diffusion unit: Design and its application to determination of ethanol in liquors by spectrophotometric flow injection en-subtitle= kn-subtitle= en-abstract= kn-abstract=This work presents new design of a gas diffusion unit, called 'membraneless gas diffusion (MGD) unit', which, unlike a conventional gas diffusion (GD) unit, allows selective detection of volatile compounds to be made without the need of a hydrophobic membrane. A flow injection method was developed employing the MGD unit to determine ethanol in alcoholic drinks based on the reduction of dichromate by ethanol vapor. Results clearly demonstrated that the MGD unit was suitable for determination of ethanol in beer, wine and distilled liquors. Detection limit (3S/N) of MGD unit was lower than the GD unit (GD: 0.68%, v/v; MGD: 0.27%, v/v). The MGD design makes the system more sensitive as mass transfer is more efficient than that of GD and thus, MGD can perfectly replace membrane-based designs. en-copyright= kn-copyright= en-aut-name=ChoengchanN. en-aut-sei=Choengchan en-aut-mei=N. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MantimT. en-aut-sei=Mantim en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WilairatP. en-aut-sei=Wilairat en-aut-mei=P. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DasguptaP. K. en-aut-sei=Dasgupta en-aut-mei=P. K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=5 ORCID= en-aut-name=NacaprichaD. en-aut-sei=Nacapricha en-aut-mei=D. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Flow Innovation-Research for Science and Technology Laboratories, Department of Chemistry, Faculty of Science, Mahidol University affil-num=2 en-affil= kn-affil=Flow Innovation-Research for Science and Technology Laboratories, Department of Chemistry, Faculty of Science, Mahidol University affil-num=3 en-affil= kn-affil=Flow Innovation-Research for Science and Technology Laboratories, Department of Chemistry, Faculty of Science, Mahidol University affil-num=4 en-affil= kn-affil=Department of Chemistry and Biochemistry, Texas Tech University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=6 en-affil= kn-affil=Flow Innovation-Research for Science and Technology Laboratories, Department of Chemistry, Faculty of Science, Mahidol University en-keyword=membraneless gas diffusion kn-keyword=membraneless gas diffusion en-keyword=flow injection kn-keyword=flow injection en-keyword=ethanol determination kn-keyword=ethanol determination en-keyword=liquor kn-keyword=liquor en-keyword=spectrophotometry kn-keyword=spectrophotometry END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=5 article-no= start-page=1256 end-page=1260 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080523 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of chitosan-based resins modified with tris(2-aminoethyl)amine moiety and its application to collection/concentration and determination of trace mercury by inductively coupled plasma atomic emission spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A novel chitosan-based chelating resin modified with tris(2-aminoethyl)amine moiety (CCTS-TAA) was synthesized. and its characteristics in the collection/concentration of mercury was examined. The synthesized resin showed good adsorption toward mercury in a wide pH range, and the adsorbed mercury can be easily eluted by using 2 M HNO3 without any addition of complexing agent. The resin was then packed in a mini-column and the mini-column was installed on a computer-controlled automated-pretreatment (Auto-Pret) system coupled with inductively coupled plasma-atomic emission spectroscopy (ICP-AES) for on-line mercury collection and determination at trace level.

en-copyright= kn-copyright= en-aut-name=HakimLukman en-aut-sei=Hakim en-aut-mei=Lukman kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=resin kn-keyword=resin en-keyword=chitosan kn-keyword=chitosan en-keyword=tris(2-aminoethyl)amine moiety kn-keyword=tris(2-aminoethyl)amine moiety en-keyword=mercury kn-keyword=mercury en-keyword=on-line pretreatment kn-keyword=on-line pretreatment en-keyword=computer control kn-keyword=computer control en-keyword=inductively coupled plasma-atomic kn-keyword=inductively coupled plasma-atomic en-keyword=emission spectrometry kn-keyword=emission spectrometry END start-ver=1.4 cd-journal=joma no-vol=1069 cd-vols= no-issue=2 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050502 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Capillary zone electrophoretic studies of ion association between inorganic anions and tetraalkylammonium ions in aqueous-dioxane media en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Ion association between inorganic anions and symmetrical tetraalkylammonium ions, R4N+ (R = Me, Et, Pr, n-Bu, n-Am, and 2-methyl butyl {isoamyl = iAm}) was investigated using ordinary silica capillary by capillary zone electrophoresis. An improved version of the Williams-Vigh method was used for the first time to measure the mobilities of the inorganic anions. Plots of log K-ass against log dielectric constant in various media, revealed a smaller change in K-ass compared to dielectric constant. These plots suggest that the Bjerrum's equation is inadequate in accounting for the associations of ions in a CZE setup.

en-copyright= kn-copyright= en-aut-name=MbunaJulius en-aut-sei=Mbuna en-aut-mei=Julius kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakayanagiToshio en-aut-sei=Takayanagi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=aqueous-dioxane media kn-keyword=aqueous-dioxane media en-keyword=Williams-Vigh method kn-keyword=Williams-Vigh method en-keyword=ion association kn-keyword=ion association en-keyword=capillary zone electrophoresis kn-keyword=capillary zone electrophoresis END start-ver=1.4 cd-journal=joma no-vol=620 cd-vols= no-issue=1-2 article-no= start-page=50 end-page=54 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080714 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A caffeine-sensitive membrane electrode: Previous misleading report and present approach en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although a previous study [S.S.M. Hassan, M.A. Ahmed, M.M. Saoudi, Anal. Chem. 57 (1985) 1126] had shown that a caffeine-sensitive electrode made with picrylsulfonate and 1-octanol as a cation-exchanger and a solvent mediator, respectively, had a wide working pH range (5.5-9.5) and exhibited a Nernstian response, we could not find such response in this electrode. The present result was reasonable, because the pK, value of caffeinium ion was reported to be around 0.7 and the neutral form of caffeine was predominant in the pH range examined. Thus, we reinvestigated the response characteristics of a caffeine electrode, taking into consideration the pKa value, and constructed a new electrode with a combination of the lipophilic cation-exchanger, tetrakis[3,5-bis(2-methoxyhexafluoro-2-propyl)phenyl]borate (HFPB), and the solvent mediator with high degree of dielectric constant, 2-fluoro-2'-nitrodiphenyl ether (FNDPE). This electrode showed a pH-dependent response to caffeinium ion and gave a detection limit of 50 mu M with a slope of 55 mV per concentration decade at pH 2. The use of other solvent mediators was less effective than that of FNDPE. The electrode was applied for the determination of caffeine in some central stimulants. en-copyright= kn-copyright= en-aut-name=KatsuTakashi en-aut-sei=Katsu en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsunamotoYumi en-aut-sei=Tsunamoto en-aut-mei=Yumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HaniokaNobumitsu en-aut-sei=Hanioka en-aut-mei=Nobumitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KomagoeKeiko en-aut-sei=Komagoe en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MasudaKazufumi en-aut-sei=Masuda en-aut-mei=Kazufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NarimatsuShizuo en-aut-sei=Narimatsu en-aut-mei=Shizuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=6 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=ion-selective electrode kn-keyword=ion-selective electrode en-keyword=caffeinium ion kn-keyword=caffeinium ion en-keyword=solvent mediator kn-keyword=solvent mediator en-keyword=2-fluoro-2 '-nitrodiphenyl ether kn-keyword=2-fluoro-2 '-nitrodiphenyl ether en-keyword=caffeine determination kn-keyword=caffeine determination END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=4 article-no= start-page=977 end-page=985 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070819 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of cross-linked chitosan functionalized with threonine moiety and its application to on-line collection/concentration and determination of Mo, V and Cu en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A novel chitosan-based resin functionalized with threonine moiety was synthesized, and applied to the collection/concentration of Mo, V and Cu in environmental water samples, followed by their determination using inductively coupled plasma-atomic emission spectrometer (ICP-AES). The synthesized resin, cross-linked chitosan-threonine (CCTS-Thr), showed good adsorption behavior toward trace amounts of Mo, V and Cu in a wide pH range. The adsorbed elements can be easily eluted using 2 mol L-1 of nitric acid, and their recoveries were found to be 90-100%. The CCTS-Thr was packed in a mini-column, which was then installed in a computer-controlled auto-pretreatment system (Auto-Pret System) for on-line trace elements collection and determination by ICP-AES. Experimental parameters related to the improvement of sensitivity and reproducibility were optimized. The limits of detection (LODs) for target metals were found to be in sub-ppb level. The proposed method with CCTS-Thr resin was successfully applied to the determination of Mo, V and Cu in environmental water samples. The recovery test showed that common matrices which exist in environmental water samples did not interfere with the determination.

en-copyright= kn-copyright= en-aut-name=HakimLukman en-aut-sei=Hakim en-aut-mei=Lukman kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=resin kn-keyword=resin en-keyword=chitosan kn-keyword=chitosan en-keyword=threonine moiety kn-keyword=threonine moiety en-keyword=molybdenum kn-keyword=molybdenum en-keyword=vanadium kn-keyword=vanadium en-keyword=copper kn-keyword=copper en-keyword=on-line pretreatment kn-keyword=on-line pretreatment en-keyword=computer control kn-keyword=computer control en-keyword=inductively coupled plasma-atomic emission spectrometry kn-keyword=inductively coupled plasma-atomic emission spectrometry END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=5 article-no= start-page=831 end-page=837 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070522 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Functionalization of chitosan with 3-nitro-4-amino benzoic acid moiety and its application to the collection/concentration of molybdenum in environmental water samples en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A chitosan resin functionalized with 3-nitro-4-amino benzoic acid moiety (CCTS-NABA resin) was newly synthesized for the collection/concentration of trace molybdenum by using cross-linked chitosan (CCTS) as base material. The carboxyl group of the moiety was chemically attached to amino group of cross-linked chitosan through amide bond formation. The adsorption behavior of molybdenum as well as other 60 elements on the resin was examined by passing the sample solutions through a mini-column packed with the resin. After the elution of the elements collected on the resin with 1 M HNO3, the eluates were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) and atomic emission spectrometry (ICP-AES).
The CCTS-NABA resin can adsorb several metal ions, such as vanadium, gallium, arsenic, selenium, silver, bismuth, thorium, tungsten, tin, tellurium, copper, and molybdenum at appropriate pHs. Among these metal ions, only molybdenum could be adsorbed almost completely on the resin at acidic regions. An excellent selectivity toward molybdenum could be obtained at pH 3-4. The adsorption capacity of CCTS-NABA resin for Mo(VI) was 380 mg g(-1) resin. Through the column pretreatment, alkali and alkaline earth metals in river water and seawater samples were successfully removed.
The CCTS-NABA resin was applied to the adsorption/collection of molybdenum in river water and seawater samples. The concentrations of molybdenum in river water samples were found in the range of 0.84 and 0.95 ppb (ng g(-1)), whereas molybdenum in seawater was about 9 ppb. The validation of the proposed method was carried out by determining molybdenum in the certified reference materials of SLRS-4, CASS-4, and NASS-5 after passing through the CCTS-NABA resin; the results showed good agreement with the certified-values.

en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=2 ORCID= en-aut-name=NoguchiOsamu en-aut-sei=Noguchi en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Brawijaya University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=chitosan resin kn-keyword=chitosan resin en-keyword=3-nitro-4-amino benzoic acid kn-keyword=3-nitro-4-amino benzoic acid en-keyword=molybdenum kn-keyword=molybdenum en-keyword=adsorption behavior kn-keyword=adsorption behavior en-keyword=water and seawater kn-keyword=water and seawater en-keyword=ICP-MS kn-keyword=ICP-MS en-keyword=ICP-AES kn-keyword=ICP-AES en-keyword=certified reference materials kn-keyword=certified reference materials END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=5 article-no= start-page=1259 end-page=1265 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041215 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Simple flow-injection system for the simultaneous determination of nitrite and nitrate in water samples en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A novel spectrophotometric reaction system was developed for the determination of nitrite as well as nitrate in water samples, and was applied to a flow-injection analysis (FIA). The spectrophotometric flow-injection system coupled with a copperised cadmium reductor column was proposed. The detection was based on the nitrosation reaction between nitrite ion and phloroglucinol (1,3,5-trihydroxybenzene), a commercially available phenolic compound. Sample injected into a carrier stream was split into two streams at the Y-shaped connector. One of the streams merged directly and reacted with the reagent stream: nitrite ion in the samples was detected. The other stream was passed through the copperised cadmium reductor column, where the reduction of nitrate to nitrite occurred, and the sample zone was then mixed with the reagent stream and passed through the detector: the sum of nitrate and nitrite was detected. The optimised conditions allow a linear calibration range of 0.03-0.30 mug NO2--N ml(-1) and 0.10-1.00 mug NO3--N ml(-1). The detection limits for nitrite and nitrate, defined as three times the standard deviation of measured blanks are 2.9 ng NO2--N ml(-1) and 2.3 ng NO3--N ml(-1), respectively. Up to 20 samples can be analyzed per hour with a relative standard deviation of less than 1.5%. The proposed method could be applied successfully to the simultaneous determination of nitrite and nitrate in water samples.

en-copyright= kn-copyright= en-aut-name=BurakhamRodjana en-aut-sei=Burakham en-aut-mei=Rodjana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=2 ORCID= en-aut-name=GrudpanKate en-aut-sei=Grudpan en-aut-mei=Kate kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chiang Mai University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Chiang Mai University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Flow-injection analysis kn-keyword=Flow-injection analysis en-keyword=Phloroglucinol kn-keyword=Phloroglucinol en-keyword=Nitrite kn-keyword=Nitrite en-keyword=Nitrate kn-keyword=Nitrate en-keyword=Simultaneous determination kn-keyword=Simultaneous determination END start-ver=1.4 cd-journal=joma no-vol=387 cd-vols= no-issue=6 article-no= start-page=2057 end-page=2064 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200703 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=S,S,S-Tris(2-ethylhexyl) phosphorotrithioate as an effective solvent mediator for a mexiletine-sensitive membrane electrode en-subtitle= kn-subtitle= en-abstract= kn-abstract=S,S,S-Tris(2-ethylhexyl) phosphorotrithioate proved to be an effective solvent mediator for constructing a mexiletine-sensitive membrane electrode in combination with an ion-exchanger, sodium tetrakis[3,5-bis(2-methoxyhexafluoro-2-propyl)phenyl]borate. Among a series of phosphorus compounds containing phosphoryl (P=O) groups, this solvent mediator showed the highest sensitivity to mexiletine in phosphate-buffered physiological saline containing 0.15 mol L-1 NaCl and 0.01 mol L-1 NaH2PO4/Na2HPO4 (pH 7.4), giving a detection limit of 2 x 10(-6) mol L-1 with a slope of 58.8 mV decade(-1). This is the best reported detection limit of any mexiletine-sensitive electrode developed to date. Owing to its high selectivity toward inorganic cations, the electrode was used to determine the level of mexiletine in saliva, the monitoring of which is quite effective for controlling the dose of this drug noninvasively. The mexiletine concentrations determined with the mexiletine-sensitive electrode compared favorably with those determined by high-performance liquid chromatography. en-copyright= kn-copyright= en-aut-name=KatsuTakashi en-aut-sei=Katsu en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsunamotoYumi en-aut-sei=Tsunamoto en-aut-mei=Yumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HaniokaNobumitsu en-aut-sei=Hanioka en-aut-mei=Nobumitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KomagoeKeiko en-aut-sei=Komagoe en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MasudaKazufumi en-aut-sei=Masuda en-aut-mei=Kazufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NarimatsuShizuo en-aut-sei=Narimatsu en-aut-mei=Shizuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=5 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=6 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University en-keyword=Ion-selective electrode kn-keyword=Ion-selective electrode en-keyword=Mexiletine determination kn-keyword=Mexiletine determination en-keyword=S,S,S-Tris(2-ethylhexyl) phosphorotrithioate kn-keyword=S,S,S-Tris(2-ethylhexyl) phosphorotrithioate en-keyword=Solvent mediator kn-keyword=Solvent mediator en-keyword=Drug monitoring kn-keyword=Drug monitoring END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5 article-no= start-page=1609 end-page=1617 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070118 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Sequential-injection on-line preconcentration using chitosan resin functionalized with 2-amino-5-hydroxy benzoic acid for the determination of trace elements in environmental water samples by inductively coupled plasma-atomic emission spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A new chelating resin using chitosan as a base material was synthesized. Functional moiety of 2-amino-5-hydroxy benzoic acid (AHBA) was chemically bonded to the amino group of cross-linked chitosan (CCTS) through the arm of chloromethyloxirane (CCTS-AHBA resin). Several elements, such as Ag, Be, Cd, Co, Cu, Ni, Ph, U, V, and rare earth elements (REEs), could be adsorbed on the resin. To use the resin for on-line pretreatment, the resin was packed in a mini-column and installed into a sequential-injection/automated pretreatment system (Auto-Pret System) coupled with inductively coupled plasma-atomic emission spectrometry (ICP-AES). The sequential-injection/automated pretreatment system was a laboratory-assembled, and the program was written using Visual Basic software. This system can provide easy operation procedures, less reagent consumption, as well as less waste production. Experimental variables considered as effective factors in the improvement sensitivity, such as an eluent concentration, a sample and an eluent flow rate, pH of samples, and air-sandwiched eluent were carefully optimized. The proposed system provides excellent on-line collection efficiency, as well as high concentration factors of analytes in water samples, which results in highly sensitive detection of ultra-trace and trace analysis. Under the optimal conditions, the detection limits of 24 elements examined are in the range from ppt to sub-ppb levels. The proposed method was validated by using the standard reference material of a river water, SLRS-4, and the applicability was further demonstrated to the on-line collection/concentration of trace elements, such as Ag, Be, Cd, Co, Cu, Ni, Ph, U, V, and REEs in water samples.

en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=LenghorNarong en-aut-sei=Lenghor en-aut-mei=Narong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=HakimLukman en-aut-sei=Hakim en-aut-mei=Lukman kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakayanagiToshio en-aut-sei=Takayanagi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=GaoYun-Hua en-aut-sei=Gao en-aut-mei=Yun-Hua kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=6 en-affil= kn-affil=Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS) affil-num=7 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=sequential-injection kn-keyword=sequential-injection en-keyword=on-line preconcentration kn-keyword=on-line preconcentration en-keyword=trace elements kn-keyword=trace elements en-keyword=ICP-AES kn-keyword=ICP-AES en-keyword=chitosan resin kn-keyword=chitosan resin END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=12 article-no= start-page=1431 end-page=1434 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071211 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Adsorption behavior of cationic and anionic species on chitosan resins possessing amino acid moieties en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Chitosan resins modified with amino acids, such as glycine, valine, leucine, and serine, were synthesized for investigating the adsorption behavior of cationic and anionic species, and showed good abilities for the adsorption of trace elements in aquatic media as follows: glycine for lanthanoids at pH 7, leucine for molybdenum at pH 1 - 5, serine for uranium at pH 2 - 7, and amino acids for bismuth at pH 1 - 7. Cationic and anionic species could be adsorbed by a chelating mechanism and an anion-exchange mechanism.

en-copyright= kn-copyright= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakayanagiToshio en-aut-sei=Takayanagi en-aut-mei=Toshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of International Conservation Studies for Cultural Properties, Faculty of Cultural Properties, Kibi International University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=CHEMICALLY-MODIFIED CHITOSAN kn-keyword=CHEMICALLY-MODIFIED CHITOSAN en-keyword=SELECTIVE ADSORPTION kn-keyword=SELECTIVE ADSORPTION en-keyword=ICP-MS kn-keyword=ICP-MS en-keyword=COLUMN COLLECTION/CONCENTRATION kn-keyword=COLUMN COLLECTION/CONCENTRATION en-keyword=COMPLEXANE TYPES kn-keyword=COMPLEXANE TYPES en-keyword=PRECIOUS METALS kn-keyword=PRECIOUS METALS en-keyword=DERIVATIVES kn-keyword=DERIVATIVES en-keyword=ION kn-keyword=ION en-keyword=COPRECIPITATION kn-keyword=COPRECIPITATION en-keyword=COPPER(II) kn-keyword=COPPER(II) END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=10 article-no= start-page=1203 end-page=1208 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20071010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of cross-linked chitosan modified with the glycine moiety for the collection/concentration of bismuth in aquatic samples for ICP-MS determination en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A chelating resin, cross-linked chitosan modified with the glycine moiety (glycine-type chitosan resin), was developed for the collection and concentration of bismuth in aquatic samples for ICP-MS measurements. The adsorption behavior of bismuth and 55 elements on glycine-type chitosan resin was systematically examined by passing a sample solution containing 56 elements through a mini-column packed with the resin (wet volume; I ml). After eluting the elements adsorbed on the resin with nitric acid, the eluates were measured by ICP-MS. The glycine-type chitosan resin could adsorb several cations by a chelating mechanism and several oxoanions by an anion-exchange mechanism. Especially, the resin could adsorb almost 100% Bi(III) over a wide pH region from pH 2 to 6. Bismuth could be strongly adsorbed at pH 3, and eluted quantitatively with 10 ml of 3 M nitric acid. A column pretreatment method with the glycine-type chitosan resin was used prior to removal of high concentrations of matrices in a seawater sample and the preconcentration of trace bismuth in river water samples for ICP-MS measurements. The column pretreatment method was also applied to the determination of bismuth in real samples by ICP-MS. The LOD of bismuth was 0.1 pg ml(-1) by 10-fold column preconcentration for ICP-MS measurements. The analytical results for bismuth in sea and river water samples by ICP-MS were 22.9 +/- 0.5 pg ml(-1) (RSD, 2.2%) and 2.08 +/- 0.05 pg ml(-1) (RSD, 2.4%), respectively.

en-copyright= kn-copyright= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NoguchiOsamu en-aut-sei=Noguchi en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of International Conservation Studies for Cultural Properties, Faculty of Cultural Properties, Kibi International University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue=6 article-no= start-page=669 end-page=682 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20061201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Automated online preconcentration system for the determination of trace amounts of lead using Pb-selective resin and inductively coupled plasma-atomic emission spectrometry en-subtitle= kn-subtitle= en-abstract= kn-abstract=

An automated sequential-injection online preconcentration system was developed for the determination of lead by inductively coupled plasma - atomic emission spectrometry (ICP-AES). The preconcentration of lead was performed with a minicolumn containing a lead-selective resin, Analig Pb-01, which was installed between a selection and a switching valve. In an acidic condition ( pH 1), lead could be adsorbed on the resin. The concentrated lead was afterward eluted with 25 mu L of 0.06 M nitrilotriacetic acid (NTA) solution ( pH 9) and was subsequently transported into the nebulizer of ICP-AES for quantification. The selectivity of the resin toward lead was examined using a solution containing a mixture of 61 elements. When a sample volume of 5 mL was used, the quantitative collection of lead ( >= 97%) was achieved, along with an enrichment factor of 19, a sampling frequency of 12 samples hr(-1), a detection limit of 70 pg mL(-1), and a lowest quantification limit of 100 pg mL(-1). The linear dynamic range was 0.1 to 5 ng mL(-1), and the relative standard deviation (n = 9) was 0.5% at a 5 ng mL(-1) Pb level. The detection limit of 30 pg mL(-1) and lowest quantification limit of 50 pg mL(-1) could be achieved when 10 mL of sample volume was used. The accuracy of the proposed method was validated by determining lead in the standard reference material of river water (SLRS-4), and its applicability to the determination of lead in environmental river water samples was demonstrated.

en-copyright= kn-copyright= en-aut-name=SabarudinA. en-aut-sei=Sabarudin en-aut-mei=A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=LenghorN. en-aut-sei=Lenghor en-aut-mei=N. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=LipingY. en-aut-sei=Liping en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FurushoY. en-aut-sei=Furusho en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Center Laboratory, Faculty of Science, JiangXi Agricultural University affil-num=4 en-affil= kn-affil=GL Sciences, Inc. affil-num=5 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=nline prdetermination of lead kn-keyword=nline prdetermination of lead en-keyword=ICP-AES kn-keyword=ICP-AES en-keyword=oeconcentration kn-keyword=oeconcentration en-keyword=Pb-selective resin kn-keyword=Pb-selective resin en-keyword=sequential injection kn-keyword=sequential injection END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=1 article-no= start-page=136 end-page=144 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of cross-linked chitosan possessing N-methyl-D-glucamine moiety (CCTS-NMDG) for adsorption/concentration of boron in water samples and its accurate measurement by ICP-MS and ICP-AES en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A chitosan resin derivatized with N-methyl-(D)-glucamine (CCTS-NMDG) was synthesized by using a cross-linked chitosan (CCTS) as base material. The N-methyl-D-glucamine (NMDG) moiety was attached to the amino group of CCTS through the arm of chloromethyloxirane. The adsorption behavior of 59 elements on the synthesized resin was systematically examined by using the resin packed in a mini-column, passing water samples through it and measuring the adsorbed elements in eluates by ICP-MS. The CCTS-NMDG resin shows high ability in boron sorption with the capacity of 0.61 mmol ml(-1) (= 2.1 mmol g(-1)). The sorption kinetics of this resin was faster than that of the commercially available resins. Other advantages of the synthesized resin are: (1) quantitative collection of boron at neutral pH regions; (2) complete removal of large amounts of matrices; (3) no loss of efficiency over prolonged usage; (4) effective collection of boron in wide range concentration using a mini column containing 1 ml resin; (5) complete elution of boron with 1 mol 1(-1) nitric acid. The resin was applied to the collection/concentration of boron in water samples. Boron in tap water and river water was found to be in the range of 6-8 mu g 1(-1). The limit of detection (LOD) of boron after pretreatment with CCTS-NMDG resin and measurement by ICP-MS was 0.07 mu g 1(-1) and the limit of quantification (LOQ) was 0. 14 mu g 1(-1) when the volume of each sample and eluent was 10 ml.

en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OshitaKoji en-aut-sei=Oshita en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=chitosan resin kn-keyword=chitosan resin en-keyword=N-methyl-D-glucamine kn-keyword=N-methyl-D-glucamine en-keyword=boron kn-keyword=boron en-keyword=adsorption kn-keyword=adsorption en-keyword=ICP-MS/AES kn-keyword=ICP-MS/AES END start-ver=1.4 cd-journal=joma no-vol=612 cd-vols= no-issue=2 article-no= start-page=165 end-page=172 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Development of novel detection reagent for simple and sensitive determination of trace amounts of formaldehyde and its application to flow injection spectrophotometric analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this paper, a novel detection reagent for formaldehyde determination is proposed, and is applied to a simple and highly sensitive flow injection method for the spectrophotometric determination of formaldehyde. The method is based on the reaction of formaldehyde with methyl acetoacetate in the presence of ammonia. The increase in the absorbance of the reaction product was measured at 375 nm. An inexpensive light emitting diode (LED)based UV detector (375 nm) was, for the first time, used. Under the optimized experimental conditions, formaldehyde in an aqueous solution was determined over the concentration range from 0.25 to 20.0 x 10(-6) M with a liner calibration graph; the limit of detection (LOD) of 5 x 10(-8) M (1.5 mu g L-1) was possible. The relative standard deviation of 12 replicate measurements of 5 X 10(-6) M formaldehyde was 1.2%. Maximum sampling throughput was about 21 samples/h. The effect of potential interferences such as metals, organic compounds and other aldehyde was also examined. The analytical performance for formaldehyde determination was compared with those obtained by the conventional acetylacetone method, which uses visible absorption spectrophotometry. Finally, the proposed method was successfully applied to the determination of formaldehyde in natural water samples. en-copyright= kn-copyright= en-aut-name=LiQiong en-aut-sei=Li en-aut-mei=Qiong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SritharathikhumPiyanete en-aut-sei=Sritharathikhum en-aut-mei=Piyanete kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OshimaMitsuko en-aut-sei=Oshima en-aut-mei=Mitsuko kn-aut-name=大島光子 kn-aut-sei=大島 kn-aut-mei=光子 aut-affil-num=3 ORCID= en-aut-name=MotomizuShoji en-aut-sei=Motomizu en-aut-mei=Shoji kn-aut-name=本水昌二 kn-aut-sei=本水 kn-aut-mei=昌二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University affil-num=4 en-affil= kn-affil=Department of Chemistry, Faculty of Science, Okayama University en-keyword=Flow injection kn-keyword=Flow injection en-keyword=Formaldehyde determination kn-keyword=Formaldehyde determination en-keyword=Spectrophotometry kn-keyword=Spectrophotometry en-keyword=Methyl acetoacetate kn-keyword=Methyl acetoacetate en-keyword=UV-light emitting diode (LED) kn-keyword=UV-light emitting diode (LED) END