| ID | 14116 |
| Eprint ID | 14116
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| FullText URL | |
| Title Alternative | Endothelium-derived nitric oxide and adenosine in functional myocardial hyperemia
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| Author |
Maekawa, Kiyoaki
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| Abstract | To investigate the role of endothelium-derived nitric oxide (EDNO) and adenosine in functional myocardial hyperemia, we examined the effect of N(G)-nitro-L-arginine (NNLA) and 8-p-sulfophenyl-theophyllin (8-ST) on coronary vasodilation in response to increased myocardial oxygen consumption (MVO(2)) in anesthesized dogs. NNLA significantly attenuated the increase in coronary conductance from 28±6% to 16±2% with atrial pacing, from 69±5% to 36±6% with isoproterenol and from 25±6% to 9±4% with constriction of the aorta. The combined administration of NNLA and 8-ST did not further change coronary conductance. It appears that EDNO may play an important role in functional hyperemia. EDNO and adenosine may interact to produce coronary vasodilation when MVO(2) increases.
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| Keywords | endothelium-derived nitric oxide
adenosine
coronary conductance
functional hyperemia
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| Note | 原著
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| Published Date | 1994
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume106
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| Issue | issue5-6
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 613
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| End Page | 620
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/106/5-6/106_5-6_613/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/
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| language |
Japanese
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| Copyright Holders | Copyright© 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
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