腸管内bilirubinの還元過程に関する研究 第2編 抗生剤内服患者の屎濾液を以てするbilirubinの還元について

The separation of bilirubinoide in the anaerobic cultured solution of bilirubin with the fecal filtrate of the patient taking antibiotics and the cultured solution of the above fecal filrate in the phosphate pepton solution for 24hours under the anaerobic condition was attempted. And the results were as follows. 1. Indirect, direct bilirubin and mesobilirubin were separated at the 12th hour, same products at the 24th hour, dihydromesobilirubin and the above products at the 36th hour and urobilin and the above products at the 48th hour after the action of fecal filtrate to bilirubin, but only urobilin was identified after 72hours. 2. Indirect-, direct bilirubin, dihydromesobilirubin were separated at the 12th hour, indirect bilirubin and mesobilirubin at the 24th hour, dihydromesobilirubin at the 36th hour, and indirect bilirubin, mesobilirubin, dihydromesobilirubin and urobilin at the 48th hour after the anaerobic incubation of bilirubin with the cultured solution of a small amount of fecal filtrate in the phosphate pepton solution, but only urobilin was identified after 72hours. 3. Bilirubin was reduced to urobilinogen pasing though mesobilirubin, dihydromesobilirubin by anaerobic bacterial flora and it's reduction process was same to the reduction process of bilirubin by colloidal palladium, clarified by H. Fischer.