start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=4 article-no= start-page=1769 end-page=1784 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=P53-armed Oncolytic Adenovirus Enhances the Efficacy of PD-1 Blockade in Neuroblastoma by Inducing Immunogenic Cell Death en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background/Aim: Neuroblastoma (NB) is a primary malignant tumor of the peripheral sympathetic nervous system. Although immunotherapy with immune checkpoint inhibitors (ICIs) targeting programmed cell death 1 (PD-1)/PD ligand 1 (PD-L1) has emerged as novel antitumor therapy, high-risk NB tumors are refractory to ICI therapy. Oncolytic virotherapy is expected to potentiate the antitumor immune response by inducing immunogenic cell death (ICD). In the present study, we assessed the therapeutic potential of OBP-301 and OBP-702, telomerase-specific oncolytic adenoviruses, for the induction of ICD and combined effect with PD-1 blockade against NB cells.
Materials and Methods: The cytopathic activity of OBP-301 and OBP-702 was assessed using three human MYCN-amplified NB cell lines (IMR-32, LA-N-5, and NB-1) and a murine non-MYCN-amplified NB cell line (Neuro-2a). Virus-mediated antitumor effect was assessed by analyzing cell viability, secretion of extracellular adenosine triphosphate (ATP) and high-mobility group box protein B1 (HMGB1), apoptosis, autophagy, and PD-L1 levels. A subcutaneous Neuro-2a tumor model was used to evaluate the in vivo antitumor effect of combination therapy with OBP-702 and anti-PD-1 antibody.
Results: OBP-702 exhibited stronger cytopathic activity, inducing ICD with secretion of ATP and HMGB1, compared to OBP-301 in human and murine NB cells. OBP-301 and OBP-702 increased apoptosis, autophagy, and PD-L1 expression in murine NB cells. Moreover, OBP-702 significantly prolonged the survival of tumor-bearing mice compared to monotherapy with PD-1 blockade.
Conclusion: OBP-702 is a promising antitumor strategy to promote the antitumor effect of ICIs by inducing ICD against NB tumors. en-copyright= kn-copyright= en-aut-name=TANIMORIMICHI en-aut-sei=TANI en-aut-mei=MORIMICHI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TAZAWAHIROSHI en-aut-sei=TAZAWA en-aut-mei=HIROSHI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TANIMOTOTERUTAKA en-aut-sei=TANIMOTO en-aut-mei=TERUTAKA kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NOUSOHIROSHI en-aut-sei=NOUSO en-aut-mei=HIROSHI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WATANABEHINAKO en-aut-sei=WATANABE en-aut-mei=HINAKO kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OYAMATAKANORI en-aut-sei=OYAMA en-aut-mei=TAKANORI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=URATAYASUO en-aut-sei=URATA en-aut-mei=YASUO kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KAGAWASHUNSUKE en-aut-sei=KAGAWA en-aut-mei=SHUNSUKE kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NODATAKUO en-aut-sei=NODA en-aut-mei=TAKUO kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KURODASHINJI en-aut-sei=KURODA en-aut-mei=SHINJI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FUJIWARATOSHIYOSHI en-aut-sei=FUJIWARA en-aut-mei=TOSHIYOSHI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Oncolys BioPharma, Inc. kn-affil= affil-num=8 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Neuroblastoma kn-keyword=Neuroblastoma en-keyword=oncolytic adenovirus kn-keyword=oncolytic adenovirus en-keyword=p53 kn-keyword=p53 en-keyword=immunogenic cell death kn-keyword=immunogenic cell death en-keyword=PD-1 kn-keyword=PD-1 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=200403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The seed collection pictorial record of ruins exrcavartion kn-title=ˆâÕoŽm‚ÌŽíŽqW¬}˜^ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ŽR–{‰x¢ kn-aut-sei=ŽR–{ kn-aut-mei=‰x¢ aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Šâú±Žu•Û kn-aut-sei=Šâú± kn-aut-mei=Žu•Û aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰«—zŽq kn-aut-sei=‰« kn-aut-mei=—zŽq aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw–„‘ •¶‰»à’²¸Œ¤‹†ƒZƒ“ƒ^[ affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw–„‘ •¶‰»à’²¸Œ¤‹†ƒZƒ“ƒ^[ affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwŠÂ‹«—HŠw•” END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=24 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ŽZ”‰Èu•”•ª‚ɑ΂·‚é•”•ª‚ÌŠ„‡‚É“–‚½‚é‘å‚«‚³v‚Ì–â‘è‰ðŒˆ‚Ì‚½‚ß‚Ì‘«ê‚ª‚¯ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@¬Šw‚T”N¶Œü‚¯‚̈ꕔ‚ÌŽZ”‰È‹³‰È‘‚Å‚ÍC•”•ª‚ɑ΂·‚é•”•ª‚ÌŠ„‡‚É“–‚½‚é‘å‚«‚³‚ð‹‚ß‚é–â‘肪ˆµ‚í‚ê‚Ä‚¢‚éD‚µ‚©‚µC‚»‚Ì–â‘è‰ðŒˆ‚ͬŠw‚T”N¶‚É‚Í—eˆÕ‚Å‚Í‚È‚¢‚Æl‚¦‚ç‚ê‚éD‚»‚±‚Å–{e‚ÍC‚ǂ̂悤‚ÈŽx‰‡‚ª•”•ª‚ɑ΂·‚é•”•ª‚ÌŠ„‡‚É“–‚½‚é‘å‚«‚³‚ð‹‚ß‚é–â‘è‰ðŒˆ‚É—LŒø‚Å‚ ‚é‚©‚𖾂炩‚É‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚½D‘«ê‚ª‚¯ (Scaffolding) ‚ð—˜_“I˜g‘g‚Ý‚Æ‚µ‚ÄC‹ï‘Ì“I‚È‘«ê‚ª‚¯‚ð\‘z‚µCŽö‹Æ‚ðŽÀ‘H‚µ‚½D‚»‚ÌŒ‹‰ÊCuŠwKŽÒ‚Ì“ª‚Ì’†‚Å‘ÌŒ±“I‚ɃŠƒAƒ‹‚È–â‘è‚Æ‚È‚é‚悤–â‘è‚ðH•v‚·‚邱‚ÆvCuŽ™“¶‚ɃAƒCƒfƒA‚̈ꕔ (‚ǂ̂悤‚È}“I•\Œ»‚ð—p‚¢‚½‚©) ‚ðЉ‚¹‚邱‚ÆvCu}“I•\Œ»‚ð—p‚¢‚é‚悤‘£‚·‚±‚ÆvCuŽ™“¶‚Ì•K—vŠ´‚ɉž‚¶‚ÄCƒyƒA‚⬃Oƒ‹[ƒv‚Ō݂¢‚Ì–â‘è‰ðŒˆ‚ðŒ©‚¹‡‚¤‚±‚ÆvCuŽ™“¶‚ª‹³Žº‘S‘Ì‚ÅŽ©g‚Ì–â‘è‰ðŒˆ‚ð”­•\‚·‚邱‚ÆvCu‹³Žt‚ª–â‘蕶‚Ì‚Ç‚Ìî•ñ‚É’–Ú‚·‚ׂ«‚©‚ðŽwŽ¦‚·‚邱‚ÆvCuŽ™“¶‚ª‘¼‚ÌŽ™“¶‚É–â‘è‰ðŒˆ‚Ì’B¬‚ð–ÚŽw‚µ‚½à–¾‚ð‚·‚é‚±‚Æv‚ªC—LŒø‚È‘«ê‚ª‚¯‚Å‚ ‚邱‚Æ‚ªŽ¦´‚³‚ꂽD‚»‚µ‚ÄC‚»‚ê‚ç‚Ì‘«ê‚ª‚¯‚ÍCŠÖ‚í‚臂¢‹@”\‚³‚¹‚邱‚Æ‚ª—LŒø‚Èê‡‚à‚ ‚邱‚Æ‚ªŽ¦´‚³‚ꂽD en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=΋´ˆêã kn-aut-sei=΋´ kn-aut-mei=ˆêã aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=}Ž® kn-keyword=}Ž® en-keyword=Œ»ŽÀ“I”Šw‹³ˆç kn-keyword=Œ»ŽÀ“I”Šw‹³ˆç en-keyword=ŠwKŽÒŽå‘Ì kn-keyword=ŠwKŽÒŽå‘Ì en-keyword=¬ŠwZ kn-keyword=¬ŠwZ en-keyword=“Œv kn-keyword=“Œv END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Šª“ªŒ¾ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=’†ìªŽ÷ kn-aut-sei=’†ì kn-aut-mei=ªŽ÷ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Suppression of salt-enhanced apoplastic flow by salicylic acid in rice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Salinity enhances apoplastic flow, resulting in an increment of Na+ uptake and a lower K+/Na+ ratio. Salicylic acid (SA) plays an important role in improving salinity tolerance in plants. The effect of exogenous SA on apoplastic flow in salt-treated rice seedlings was studied using an apoplastic tracer, 8-hydroxy-1,3,6-pyrenetrisulphonic acid (PTS) in light. Application of NaCl at 25 mM to the hydroponic solution significantly increased PTS uptake, while 25 mM NaCl did not affect seedling growth. Application of 25 mM NaNO3 increased PTS uptake to the same degree. Salinity significantly increased sodium (Na+) content but had no significant effect on potassium (K+) content, resulting in a lower K+/Na+ ratio. The application of SA at 0.05 mM and 0.1 mM to the hydroponic solution reduced Na-enhanced PTS uptake. Salicylic acid at 0.05 mM and 0.1 mM significantly reduced Na+ content and slightly increased K+ content in the shoots of rice seedlings, resulting in a higher K+/Na+ ratio. However, SA at up to 0.1 mM did not increase SA contents in shoots under salt stress. These results suggest that exogenous SA reduces Na+ uptake by suppressing Na+-enhanced apoplastic flow in rice seedlings. These findings provide insight into modulation of Na+ transport pathways from roots to shoots by SA and may allow us to utilize brackish water for rice cultivation and to improve salt-tolerant rice through suppression of salt-enhanced apoplastic flow by chemicals such as salicylic acid. en-copyright= kn-copyright= en-aut-name=GalibMd. Asadulla Al en-aut-sei=Galib en-aut-mei=Md. Asadulla Al kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ZhaoMaoxiang en-aut-sei=Zhao en-aut-mei=Maoxiang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakamuraToshiyuki en-aut-sei=Nakamura en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakamuraYoshimasa en-aut-sei=Nakamura en-aut-mei=Yoshimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HiraiYoshihiko en-aut-sei=Hirai en-aut-mei=Yoshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakashimaYoshitaka en-aut-sei=Nakashima en-aut-mei=Yoshitaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MunemasaShintaro en-aut-sei=Munemasa en-aut-mei=Shintaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MoriIzumi C. en-aut-sei=Mori en-aut-mei=Izumi C. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MurataYoshiyuki en-aut-sei=Murata en-aut-mei=Yoshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=8 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=9 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= en-keyword=Apoplastic flow kn-keyword=Apoplastic flow en-keyword=Salicylic acid kn-keyword=Salicylic acid en-keyword=Rice kn-keyword=Rice en-keyword=Salinity kn-keyword=Salinity en-keyword=Trisodium-8-hydroxy-1,3,6-pyrenetrisulphonic acid kn-keyword=Trisodium-8-hydroxy-1,3,6-pyrenetrisulphonic acid END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue= article-no= start-page=30309 end-page=30326 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=2026 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Self-Adaptive Framework for Deploying Machine Learning Systems Without Ground-Truth Data at Runtime en-subtitle= kn-subtitle= en-abstract= kn-abstract=In recent years, the practical application of machine learning technology has rapidly progressed, accelerating its adoption across various fields. In this context, studies into the effective operation of machine learning systems in real-world environments have become essential. In actual operational settings, the distribution of input data often changes over time, leading to a significant decline in the predictive performance of models. Additionally, the lack of ground-truth data for test data during operation can sometimes make adaptation through retraining difficult. This study proposes a framework that autonomously adapts to changes in input data distribution, even in environments where ground-truth data for test data is unavailable during operation. This framework analyzes the distribution of input data and selects the appropriate predictive model based on the state of the distribution. To ensure optimal model selection, the framework employs two complementary approaches: 1) dynamically switching between multiple pre-trained models with different feature sets according to environmental changes and 2) building ensemble models based on the distribution of the test data. These approaches enable the framework to autonomously adapt to shifts in data distribution, even in operational settings where ground-truth data is unavailable. Evaluation experiments using both simulated and real-world data assessed the predictive performance of the proposed method through metrics such as R2, RMSE, and MAE. Compared to conventional single model predictions, the proposed method consistently demonstrated higher accuracy. These results indicate that the proposed approach effectively adapts to data distribution shifts in operational environments where ground-truth data is unavailable. en-copyright= kn-copyright= en-aut-name=FurukawaKento en-aut-sei=Furukawa en-aut-mei=Kento kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakagawaHiroyuki en-aut-sei=Nakagawa en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsuchiyaTatsuhiro en-aut-sei=Tsuchiya en-aut-mei=Tatsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Information Science and Technology, Osaka University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Information Science and Technology, Osaka University kn-affil= en-keyword=Self-adaptive systems kn-keyword=Self-adaptive systems en-keyword=frameworks kn-keyword=frameworks en-keyword=machine learning kn-keyword=machine learning END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=438 end-page=410 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on Water Pollution by Persistent Organic PollutantsiPFOSEPFOAj: Focused on Duty of Care in Transactions. kn-title=PFOSEPFOA “™‚ÌŽc—¯«—L‹@‰˜õ•¨Ž¿‚É‚æ‚é…Ž¿‰˜õ‚ÉŠÖ‚·‚éˆêlŽ@ \ Žæˆøã‚Ì‹`–±‚ÌŽ‹“_‚©‚ç\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TsujiH. en-aut-sei=Tsuji en-aut-mei=H. kn-aut-name=’Ò”Ž–¾ kn-aut-sei=’Ò kn-aut-mei=”Ž–¾ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw–¼—_‹³Žö END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=586 end-page=496 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Possibility of a Japanese Approach to Standards of Judicial Review kn-title=“ú–{“ÆŽ©‚̈ጛR¸Šî€˜_‚̉”\« en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ItoT. en-aut-sei=Ito en-aut-mei=T. kn-aut-name=ˆÉ“¡Œ’ kn-aut-sei=ˆÉ“¡ kn-aut-mei=Œ’ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽR‘åŠw‹³ˆç„i‹@\ ‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[‚ÌŠˆ“®ó‹µ‚ÌŠT—v en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=253 end-page=266 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=How Can School Counselors Contribute to Developmentally Supportive Student Guidance: An Examination of Support Expansion Through the Use of Planning Sheets kn-title=ƒXƒN[ƒ‹ƒJƒEƒ“ƒZƒ‰[‚Í”­’BŽxŽ“I¶“kŽw“±‚Ö‚¢‚©‚ÉvŒ£‚Å‚«‚é‚© \ƒvƒ‰ƒ“ƒjƒ“ƒOƒV[ƒg‚ÌŠˆ—p‚ð’Ê‚µ‚½Žx‰‡‚ÌŠg[‚ÉŒü‚¯‚½ŒŸ“¢\ en-subtitle= kn-subtitle= en-abstract=@In the revised Guidelines for Student Guidance (2022), the importance of developmentally supportive student guidance, which aims to foster the growth of all students, is clearly emphasized. However, many challenges to its implementation have been identified in school settings, including teachersf excessive workload and insufficient organizational support systems. Moreover, the support provided by school counselors (SCs) has not yet been sufficiently developed. Therefore, this study examined the potential for expanding SCsf support in developmentally supportive student guidance by reviewing its current status and challenges. Furthermore, through a reanalysis of a practical case using the Planning Sheet (Hara et al., 2024), the study explored the usefulness of this framework in enabling SCs and schools to share educational goals and collaboratively plan their support activities. kn-abstract=@2022”N‚ɉü’ù‚³‚ꂽu¶“kŽw“±’ñ—vv‚Å‚ÍC‚·‚ׂĂ̎™“¶¶“k‚̬’·‚ðŽx‰‡‚·‚é”­’BŽxŽ“I¶“kŽw“±‚Ìd—v«‚ª–¾Šm‚ÉŽ¦‚³‚ê‚Ä‚¢‚éB‚µ‚©‚µC‚»‚Ì’è’…‚É‚ÍC‹³ˆõ‚Ì‘½–Z‰»‚â‘gD“IŽx‰‡‘̧‚Ì•s\•ª‚³‚È‚ÇCŠwZŒ»ê‚É‚¨‚¯‚鑽‚­‚̉ۑ肪Žw“E‚³‚ê‚Ä‚¢‚éB‚³‚ç‚ÉCƒXƒN[ƒ‹ƒJƒEƒ“ƒZƒ‰[iSCj‚É‚æ‚éŽx‰‡‚à\•ª‚É“WŠJ‚³‚ê‚Ä‚¢‚é‚Æ‚ÍŒ¾‚¢“ï‚¢B‚»‚±‚Å–{e‚Å‚ÍC”­’BŽxŽ“I¶“kŽw“±‚É‚¨‚¯‚éSC‚ÌŽx‰‡‚ÌŠg[‰Â”\«‚ðŒŸ“¢‚·‚邽‚ßCŒ»ó‚Ɖۑè‚ð®—‚µ‚½B‚Ü‚½Cƒvƒ‰ƒ“ƒjƒ“ƒOƒV[ƒg‚ðŠˆ—p‚µ‚½ŽÀ‘HŽ–—áiŒ´‘¼, 2024j‚ÌÄ•ªÍ‚ð’Ê‚µ‚ÄCSC‚ÆŠwZ‚ª‹³ˆç–Ú•W‚ð‹¤—L‚µ‚È‚ª‚狦“­“I‚ÉŽx‰‡‚ðŒv‰æ‚·‚é˜g‘g‚Ý‚Ì—L—p«‚ð‹á–¡‚µ‚½B en-copyright= kn-copyright= en-aut-name=HARANoriyuki en-aut-sei=HARA en-aut-mei=Noriyuki kn-aut-name=Œ´”ÍK kn-aut-sei=Œ´ kn-aut-mei=”ÍK aut-affil-num=1 ORCID= en-aut-name=MISAWARyo en-aut-sei=MISAWA en-aut-mei=Ryo kn-aut-name=ŽO‘ò—Ç kn-aut-sei=ŽO‘ò kn-aut-mei=—Ç aut-affil-num=2 ORCID= en-aut-name=AOKITazuko en-aut-sei=AOKI en-aut-mei=Tazuko kn-aut-name=–ؑ½ŽõŽq kn-aut-sei=Â–Ø kn-aut-mei=‘½ŽõŽq aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRŒ§Œö—§ŠwZƒXƒN[ƒ‹ƒJƒEƒ“ƒZƒ‰[ affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=”­’BŽxŽ“I¶“kŽw“± (developmentally supportive student guidance) kn-keyword=”­’BŽxŽ“I¶“kŽw“± (developmentally supportive student guidance) en-keyword=ƒvƒ‰ƒ“ƒjƒ“ƒOƒV[ƒg (Planning Sheet) kn-keyword=ƒvƒ‰ƒ“ƒjƒ“ƒOƒV[ƒg (Planning Sheet) en-keyword=ƒXƒN[ƒ‹ƒJƒEƒ“ƒZƒ‰[ (school counselor) kn-keyword=ƒXƒN[ƒ‹ƒJƒEƒ“ƒZƒ‰[ (school counselor) en-keyword=ƒ`[ƒ€ŠwZ (school as a team) kn-keyword=ƒ`[ƒ€ŠwZ (school as a team) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=237 end-page=251 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Preliminary Consideration on the Introduction of Philosophical Thinking into Special Needs Education: A Methodological Framework Based on the Concepts of Duration, Becoming, and Diffraction kn-title=“Á•ÊŽx‰‡‹³ˆç‚Ö‚Ì“NŠw“IŽvl“±“ü‚ɂ‚¢‚Ä‚Ì—\”õ“IlŽ@ Ž‘±E¶¬•Ï‰»E‰ñÜ‚Ìl‚¦•û‚ÉŠî‚­•û–@“I˜g‘g‚Ý‚ÌŽŽˆÄ en-subtitle= kn-subtitle= en-abstract=This paper presents a theoretical and methodological examination aimed at introducing philosophical thinking into the practice of special needs education in response to contemporary challenges in the field. As its theoretical foundation, the study outlines Bergsonf s theory of memory, Deleuze and Guattarif s philosophy of becoming, Baradf s diffractive methodology, and Blomf s diffractive ethnography. Building upon these theories, it proposes a methodological framework that adopts three interrelated analytical perspectives?gmaterial-discursive practices,h gduration,h and gbecomingh?for reading and interpreting educational practices. These perspectives, situated within the paradigm of post-qualitative research, make it possible to understand educational events as relational and processual phenomena rather than fixed outcomes. Future issues include the theoretical integration of the three lenses, clarification of the distinctions between diffractive methodology and diffractive ethnography, and refinement of analytical methods for connecting multiple practice episodes. kn-abstract=@–{e‚ÍCŒ»‘ã‚Ì“Á•ÊŽx‰‡‹³ˆç‚̉ۑ肩‚çC“Á•ÊŽx‰‡‹³ˆçŽÀ‘H‚É“NŠw“IŽvl‚𓱓ü‚·‚邽‚ß‚Ì—˜_“IE•û–@“IŒŸ“¢‚ðs‚¤‚à‚Ì‚Å‚ ‚éB‚Ü‚¸C—˜_Šî”Õ‚Æ‚µ‚ÄCƒxƒ‹ƒNƒ\ƒ“‚Ìu‹L‰¯—˜_vCƒhƒDƒ‹[ƒY•ƒKƒ^ƒŠ‚Ìu¶¬•Ï‰»‚Ì“NŠwvCBarad‚Ìu‰ñÜ“I•û–@˜_vCBlom‚Ìu‰ñÜ“IƒGƒXƒmƒOƒ‰ƒtƒB[v‚ɂ‚¢‚ÄŠTà‚µ‚½B‚»‚µ‚ÄC—˜_Šî”Õ‚ðŠî‚É•û–@“I˜g‘g‚Ý‚Æ‚µ‚ÄCu•¨Ž¿|Œ¾à“IŽÀ‘HvCuŽ‘±vCu¶¬•Ï‰»v‚ÌŽO‚‚̎‹“_‚ð‹³ˆçŽÀ‘H‚ð“Ç‚Ý‰ð‚­‚½‚ß‚Ì‘ŠŒÝ•âŠ®“I‚È•ªÍŽ‹“_‚Æ‚µ‚ÄÌ—p‚·‚邱‚Æ‚ð’ñˆÄ‚µ‚½B‚±‚ê‚ç‚ÌŽ‹“_‚ÍCƒ|ƒXƒgŽ¿“IŒ¤‹†‚Æ‚µ‚ÄCo—ˆŽ–‚ðŠÖŒW“IE‰ß’ö“I‚É‘¨‚¦‚邱‚Æ‚ð‰Â”\‚É‚·‚é‚à‚Ì‚Å‚ ‚éB¡Œã‚̉ۑè‚Æ‚µ‚ÄCŽO‚‚̃Œƒ“ƒYŠÔ‚Ì—˜_“I®—C‰ñÜ“I•û–@˜_‚ƉñÜ“IƒGƒXƒmƒOƒ‰ƒtƒB[‚Ì·ˆÙ‰»C‚¨‚æ‚Ñ•¡”‚ÌŽÀ‘HƒGƒsƒ\[ƒh‚ðÚ‘±‚µ‚Ä•`‚­‚½‚ß‚Ì•ªÍŽè–@‚̸ãk‰»‚ª‹“‚°‚ç‚ꂽB en-copyright= kn-copyright= en-aut-name=HAMADAYo en-aut-sei=HAMADA en-aut-mei=Yo kn-aut-name=ûM“c—j kn-aut-sei=ûM“c kn-aut-mei=—j aut-affil-num=1 ORCID= en-aut-name=TAKANOMiyuki en-aut-sei=TAKANO en-aut-mei=Miyuki kn-aut-name=ûü–ì”ü—R‹I kn-aut-sei=ûü–ì kn-aut-mei=”ü—R‹I aut-affil-num=2 ORCID= en-aut-name=SATOSatoru en-aut-sei=SATO en-aut-mei=Satoru kn-aut-name=²“¡ú kn-aut-sei=²“¡ kn-aut-mei=ú aut-affil-num=3 ORCID= affil-num=1 en-affil=Okayama Prefectural Okayama Seto Special Needs School kn-affil=‰ªŽRŒ§—§‰ªŽR£ŒË‚“™Žx‰‡ŠwZ affil-num=2 en-affil=Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@ affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=“Á•ÊŽx‰‡‹³ˆç (special needs education) kn-keyword=“Á•ÊŽx‰‡‹³ˆç (special needs education) en-keyword=“NŠw (philosophy) kn-keyword=“NŠw (philosophy) en-keyword=•ªÍŽ‹“_ (analytical perspectives) kn-keyword=•ªÍŽ‹“_ (analytical perspectives) en-keyword=ƒ|ƒXƒgƒqƒ…[ƒ}ƒjƒYƒ€ (posthumanism) kn-keyword=ƒ|ƒXƒgƒqƒ…[ƒ}ƒjƒYƒ€ (posthumanism) en-keyword=Ž¿“IŒ¤‹† (qualitative research) kn-keyword=Ž¿“IŒ¤‹† (qualitative research) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=221 end-page=235 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Designing an Educational Model and Assessing Outcomes for the Graduate Course gLeadership and SDGsh New Directions in Leadership Education through Theory Learning, Peer Review, and Reflective Practice kn-title=‘åŠw‰@‹¤’ʉȖÚwƒŠ[ƒ_[ƒVƒbƒv‚ÆSDGsx‚Ì‹³ˆçƒ‚ƒfƒ‹\’z‚Ƭ‰Ê•ªÍ —˜_ŠwKEƒsƒAƒŒƒrƒ…[EÈŽ@Šˆ“®‚É‚æ‚郊[ƒ_[ƒVƒbƒv‹³ˆç‚ÌV“WŠJ en-subtitle= kn-subtitle= en-abstract=Okayama University's graduate school has developed and implemented a core course, gLeadership and SDGs,h to foster leadership among graduate students. The course focuses on the development of leaders who can contribute to the achievement of the SDGs (Sustainable Development Goals) and combines theoretical study, peer review, reflective practice, and group discussion to encourage mutual learning and self-growth among students. By analyzing learning outcomes across different departments, the study demonstrates that reflective, theory-based learning and collaborative critique activities effectively deepen leadership understanding and personal development. This research clarifies the significance of building and continuously improving an educational model that integrates academic theory and practical activities. kn-abstract=@‰ªŽR‘åŠw‘åŠw‰@‚Å‚ÍA”ŽŽm‰Û’ölނ̃Š[ƒ_[ƒVƒbƒvˆç¬‚ÉŒü‚¯A‹¤’ʉȖÚwƒŠ[ƒ_[ƒVƒbƒv‚ÆSDGsx‚ðÝŒvEŽÀ‘H‚µ‚Ä‚¢‚éB–{‰È–Ú‚ÍSDGs‚ÉvŒ£‚·‚郊[ƒ_[ˆç¬‚ÉŽåŠá‚ð’u‚«A—˜_ŠwKEƒsƒAƒŒƒrƒ…[EÈŽ@EƒOƒ‹[ƒvƒfƒBƒXƒJƒbƒVƒ‡ƒ““™‚ÌŽè–@‚ð‘g‚݇‚킹AŠw¶“¯Žm‚ÌŠw‚ч‚¢EŽ©ŒÈ¬’·‚Ì‘£i‚ð–Ú“I‚Æ‚µ‚Ä‚¢‚éB–{e‚Å‚ÍAŠw•”EŒ¤‹†‰È‚²‚Æ‚ÉŠwK¬‰Ê‚ð•ªÍ‚µA—˜_‚ÉŠî‚­Ȏ@“IŠw‚Ñ‚Æ‹¦“­“I‚È”á•]Šˆ“®‚ªƒŠ[ƒ_[ƒVƒbƒv—‰ð‚⬒·‚É—L—p‚Å‚ ‚邱‚Ƃ𖾂炩‚É‚µ‚½B–{Œ¤‹†‚ÍAŠwp“I—˜_‚ÆŽÀ‘H“IŠˆ“®‚ðD‚èŒð‚º‚½ƒ‚ƒfƒ‹\’z‚ÆA‚»‚ÌŒp‘±“I‰ü‘P‚̈Ӌ`‚ðŽ¦‚µ‚Ä‚¢‚éB en-copyright= kn-copyright= en-aut-name=ISHIDAMamoru en-aut-sei=ISHIDA en-aut-mei=Mamoru kn-aut-name=Γc‰q kn-aut-sei=Γc kn-aut-mei=‰q aut-affil-num=1 ORCID= en-aut-name=OTSUNEShinichi en-aut-sei=OTSUNE en-aut-mei=Shinichi kn-aut-name=‘åí^ˆê kn-aut-sei=‘åí kn-aut-mei=^ˆê aut-affil-num=2 ORCID= en-aut-name=NAKAZAWATakuya en-aut-sei=NAKAZAWA en-aut-mei=Takuya kn-aut-name=’†àV‘ñ–ç kn-aut-sei=’†àV kn-aut-mei=‘ñ–ç aut-affil-num=3 ORCID= affil-num=1 en-affil=Faculty of General Education and Global Studies, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹¤’Ê‹³ˆçEƒOƒ[ƒoƒ‹—̈æ affil-num=2 en-affil=Graduate student, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŠÂ‹«¶–½Ž©‘R‰ÈŠwŒ¤‹†‰È affil-num=3 en-affil=Graduate student, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŒ¤‹†‰È en-keyword=ƒŠ[ƒ_[ƒVƒbƒv‹³ˆç (Leadership Education) kn-keyword=ƒŠ[ƒ_[ƒVƒbƒv‹³ˆç (Leadership Education) en-keyword=ŠwKÝŒv (Learning Design) kn-keyword=ŠwKÝŒv (Learning Design) en-keyword=‚“™‹³ˆç (Higher Education) kn-keyword=‚“™‹³ˆç (Higher Education) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=205 end-page=219 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Tier 1 Support of School-Wide Positive Behavior Support (SWPBS) in the High School Division of a Special Needs School for Students with Intellectual Disabilities: Implementation and Effects of a Campaign-Based Approach kn-title=’m“IáŠQ‚“™“Á•ÊŽx‰‡ŠwZ‚É‚¨‚¯‚é SWPBS ‘æ‚P‘wŽx‰‡ \ƒLƒƒƒ“ƒy[ƒ“•ûŽ®‚Ì“±“ü‚Æ‚»‚ÌŒø‰Ê\ en-subtitle= kn-subtitle= en-abstract=This study examined the effects of a campaign-based intervention implemented as Tier 1 support within School-Wide Positive Behavior Support (SWPBS). It took place at a public upper secondary school for students with mild intellectual disabilities. A gThank-You Campaignh was conducted with 24 students in one grade level. The frequency of predefined target behaviors was analyzed using AB design with follow-ups. A social validity questionnaire was also administered to six teachers of the same grade. Results showed that both the frequency of the target behaviors and the percentage of students engaging in those behaviors increased after the campaign. These increases remained above baseline levels for a certain period after the campaign ended. The intervention also demonstrated a moderate degree of social validity. These findings suggest that campaign-based approaches can be a useful form of Tier 1 support in SWPBS for students with mild intellectual disabilities at the upper secondary level. kn-abstract=@–{Œ¤‹†‚ÍCŒy“x’m“IáŠQ‚Ì‚ ‚éŒãŠú’†“™‹³ˆç’iŠK‚ÌŒö—§’m“IáŠQ‚“™“Á•ÊŽx‰‡ŠwZ‚É‚¨‚¢‚ÄCSWPBS ‘æ1‘wŽx‰‡‚Æ‚µ‚ăLƒƒƒ“ƒy[ƒ“•ûŽ®‚ÌŽx‰‡‚ðŽÀŽ{‚µC‚»‚ÌŒø‰ÊŒŸØ‚ðs‚Á‚½B•û–@‚Æ‚µ‚Ä‚ÍC‚wŠw”N¶“k24–¼‚ɑ΂µ‚Ĉ¥ŽAs“®‚Ì‘£i‚ð‘_‚Á‚½ƒLƒƒƒ“ƒy[ƒ“‚ðŽÀŽ{‚µC–Ú•Ws“®‚̶‹N”‚ɂ‚¢‚ÄABƒtƒHƒ[ƒAƒbƒvƒfƒUƒCƒ“‚ð—p‚¢‚ÄŒŸ“¢‚µ‚½B‚Ü‚½C‚wŠw”N‹³ˆõ6–¼‚ɑ΂µCŽÐ‰ï“I‘Ó–«‚ð•]‰¿‚·‚éƒAƒ“ƒP[ƒg‚ðŽÀŽ{‚µ‚½B‚»‚ÌŒ‹‰ÊCƒLƒƒƒ“ƒy[ƒ“‚̉î“ü’¼Œã‚É–Ú•Ws“®‚̶‹N”‚¨‚æ‚Ñ–Ú•Ws“®‚É]Ž–‚µ‚½¶“k‚ÌŠ„‡‚Ì‘‰Á‚ªŒ©‚ç‚êCƒLƒƒƒ“ƒy[ƒ“I—¹Œã‚àƒx[ƒXƒ‰ƒCƒ“‚Æ”äŠr‚µ‚½‘‰Á‚ªˆê’èŠúŠÔŠm”F‚³‚ꂽB‚Ü‚½Cˆê’è’ö“x‚̎Љï“I‘Ó–«‚àŠm”F‚Å‚«‚½B en-copyright= kn-copyright= en-aut-name=TOKIMITSUHideaki en-aut-sei=TOKIMITSU en-aut-mei=Hideaki kn-aut-name=ŽžŒõG–¾ kn-aut-sei=ŽžŒõ kn-aut-mei=G–¾ aut-affil-num=1 ORCID= en-aut-name=MIYAZAKIYoshio en-aut-sei=MIYAZAKI en-aut-mei=Yoshio kn-aut-name=‹{ú±‘P˜Y kn-aut-sei=‹{ú± kn-aut-mei=‘P˜Y aut-affil-num=2 ORCID= en-aut-name=KOYAMAMadoka en-aut-sei=KOYAMA en-aut-mei=Madoka kn-aut-name=¬ŽR‰~ kn-aut-sei=¬ŽR kn-aut-mei=‰~ aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Education (Professional Degree Course), Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=3 en-affil=Kurashiki Kotoura Special Needs Seni or High School, Okayama Prefecture kn-affil=‰ªŽRŒ§—§‘q•~‹Õ‰Y‚“™Žx‰‡ŠwZ en-keyword=‚“™•” (High school division) kn-keyword=‚“™•” (High school division) en-keyword=Œy“x’m“IáŠQ (Mild intellectual disabilities) kn-keyword=Œy“x’m“IáŠQ (Mild intellectual disabilities) en-keyword=SWPBSiŠwZ‹K–̓|ƒWƒeƒBƒus“®Žx‰‡j(School-Wide Positive Behavior Support (SWPBS)) kn-keyword=SWPBSiŠwZ‹K–̓|ƒWƒeƒBƒus“®Žx‰‡j(School-Wide Positive Behavior Support (SWPBS)) en-keyword=‘æ1‘wŽx‰‡ (Tier 1 support) kn-keyword=‘æ1‘wŽx‰‡ (Tier 1 support) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=191 end-page=203 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Examining a Practical Case of Learning for Community Development ?Focusing on the Changes in Awareness of Junior High School Students During Integrated Studies? kn-title=’¬‚­‚è‚ðl‚¦‚éŽÀ‘HŽ–—á‚ÌŒŸ“¢ \‘‡“I‚ÈŠwK‚ÌŽžŠÔ‚ð’Ê‚¶‚½’†Šw¶‚̈ӎ¯•Ï‰»‚É’…–Ú‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract= This study aims to clarify the effects of junior high school students planning community development through collaboration and interaction with others, and the changes in learners that arise from the results of such practice. It also examines how interactions with others, which are emphasized in dialogic learning, can be applied to junior high school practice and what form this should take. The goal of this practice is to foster a change in students' awareness of their town by having them interpret the future and nature of the town from various perspectives in relation to their interactions with others, and consider sustainable ways of living in the town and forming relationships as their own concern. As a result of the practice, students experienced changes in their perspectives and awareness regarding the town and were able to think about the regional issues involved in town development as their own concern. kn-abstract=@–{Œ¤‹†‚ÍC’†ŠwZ‘‡“I‚ÈŠwK‚ÌŽžŠÔ‚É‚¨‚¯‚é’¬‚­‚è‚É‚¨‚¢‚ÄC‘¼ŽÒ‚Æ‚Ì‹¦“­‚â‘ŠŒÝì—p‚ð’Ê‚¶‚Ä’¬‚­‚è‚ð\‘z‚µCŽÀ‘H‚ÌŒ‹‰Ê¶‚¶‚½ŠwKŽÒ‚̕ω»‚©‚ç‚»‚ÌŒø‰Ê‚𖾂炩‚É‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚Ä‚¢‚éB‚Ü‚½C‘Θb“I‚ÈŠw‚Ñ‚ÅdŽ‹‚³‚ê‚鑼ŽÒ‚Æ‚Ì‘ŠŒÝì—p‚ðC’†ŠwZ‚ÌŽÀ‘H‚É—Ž‚Æ‚µž‚ÝC‚»‚Ì‚ ‚è•û‚ɂ‚¢‚Ä‚àŒŸ“¢‚·‚éB–{ŽÀ‘H‚Ì‚Ë‚ç‚¢‚ÍC‘½—l‚ÈŽ‹“_‚©‚ç’¬‚Ì«—ˆ‚ÌŽp‚â‚ ‚è•û‚ðl‚Æ‚ÌŠÖ‚í‚è‚ɂ‚¢‚ēǂ݉ð‚«CŽ‘±‰Â”\‚È’¬‚Ì‚ ‚è•û‚ɂ‚¢‚ÄŽ©•ªŽ–‚Ɉø‚«Šñ‚¹‚Äl‚¦‚邱‚Æ‚ÅC’¬‚ɑ΂·‚éˆÓŽ¯‚̕ω»‚𑣂·‚±‚Æ‚É‚ ‚éBŽÀ‘H‚ÌŒ‹‰ÊCŠwKŽÒ‚Ì’¬‚ɑ΂·‚錩•û‚âl‚¦•û‚̈ӎ¯•Ï‰»‚ªˆø‚«‹N‚±‚³‚êC’¬‚­‚è‚ÌŽ‚Â’nˆæ‰Û‘è‚ɂ‚¢‚ÄŽ©•ªŽ–‚Ɉø‚«Šñ‚¹‚ÄŽvl‚·‚邱‚Æ‚ª‚Å‚«‚½B en-copyright= kn-copyright= en-aut-name=KAMADAAkemi en-aut-sei=KAMADA en-aut-mei=Akemi kn-aut-name=Š™“c–¾”ü kn-aut-sei=Š™“c kn-aut-mei=–¾”ü aut-affil-num=1 ORCID= en-aut-name=KAJIIKazuaki en-aut-sei=KAJII en-aut-mei=Kazuaki kn-aut-name=Šˆäˆê‹Å kn-aut-sei=Šˆä kn-aut-mei=ˆê‹Å aut-affil-num=2 ORCID= affil-num=1 en-affil=Anan City Anan First Junior High School kn-affil=ˆ¢“ìŽs—§ˆ¢“ì‘æˆê’†ŠwZ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‘‡“I‚ÈŠwK‚ÌŽžŠÔ (the period for integrated studies) kn-keyword=‘‡“I‚ÈŠwK‚ÌŽžŠÔ (the period for integrated studies) en-keyword=’†Šw¶ (junior high school student) kn-keyword=’†Šw¶ (junior high school student) en-keyword=’¬‚­‚è (community development) kn-keyword=’¬‚­‚è (community development) en-keyword=‘Θb“I‚ÈŠw‚Ñ (int eractive lea rning) kn-keyword=‘Θb“I‚ÈŠw‚Ñ (int eractive lea rning) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=167 end-page=180 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Developing High School Civics Lesson Plan Aimed at Improving Understanding of Constitutionalism: Depending on gWe the Peopleh of the Center for Civic Education kn-title=—§Œ›Žå‹`‚ɑ΂·‚é”FŽ¯‚̉ü‘P‚ð–ÚŽw‚µ‚½‚“™ŠwZŒö–¯‰È‚ÌŽö‹ÆŠJ”­Œ¤‹† \•Ä‘Œö–¯‹³ˆçƒZƒ“ƒ^[ŠJ”­w‰ä‚ç‡O‘l–¯x‚ðŽè‚ª‚©‚è‚É‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract=This study aims to develop practicable lessons for high school civics classes that foster an understanding of constitutionalism as the foundation for grasping the Constitution. Traditional Japanese social studies education focused on understanding the Constitution's fundamental principles?popular sovereignty, respect for basic human rights, and pacifism. But, recently, the concept of constitutionalism has gained attention as a means to help students understand what a constitution fundamentally is, and it is now described in textbooks. This study proposes a lesson plan designed to help students appropriately grasp the concept of constitutionalism. In making the lesson plan, we referenced the long-used gWe the Peopleh program developed by the Center for Civic Education in U.S. We adapted materials originally created based on the historical context of the United States to fit the Japanese context, utilizing parts of this program. kn-abstract=@–{Œ¤‹†‚ÍAŒ›–@—‰ð‚ÌŠî–{‚Æ‚µ‚Ä‚Ì—§Œ›Žå‹`‚ɑ΂·‚é”FŽ¯Œ`¬‚ð–Ú•W‚Æ‚·‚éA‚“™ŠwZŒö–¯‰È‚ÅŽÀ‘H‰Â”\‚ÈŽö‹Æ‚ÌŠJ”­‚ð–ÚŽw‚µ‚½‚à‚Ì‚Å‚ ‚éB]—ˆ‚Ì“ú–{‚̎Љï‰È‹³ˆç‚É‚¨‚¢‚Ä‚ÍAŒ›–@—‰ð‚Í“ú–{‘Œ›–@‚ÌŠî–{Œ´‘¥‚Å‚ ‚é‘–¯ŽåŒ AŠî–{“IlŒ ‚Ì‘¸dA•½˜aŽå‹`‚Ì—‰ð‚ðŠî–{‚Æ‚µ‚Ä‚¢‚½‚ªA‹ß”NA‚»‚à‚»‚àŒ›–@‚Ƃ͉½‚©‚ð—‰ð‚³‚¹‚邽‚ß‚ÉA—§Œ›Žå‹`‚ÌŠT”O‚ª’–Ú‚³‚ê‚é‚悤‚É‚È‚èA‹³‰È‘‚É‚à‹Lq‚³‚ê‚Ä‚¢‚éB–{Œ¤‹†‚ÍA‚»‚̂悤‚È—§Œ›Žå‹`‚Æ‚¢‚¤ŠT”O‚ɂ‚¢‚Ķ“k‚É“KØ‚É—‰ð‚³‚¹‚邱‚Æ‚ð–ÚŽw‚µ‚½Žö‹Æ‚Ì’ñˆÄ‚ð‚µ‚æ‚¤‚Æ‚·‚é‚à‚Ì‚Å‚ ‚éBŽö‹ÆŒv‰æ쬂ɂ ‚½‚Á‚Ä‚ÍA•Ä‘‚ÌŒö–¯‹³ˆçƒZƒ“ƒ^[‚ªŠJ”­‚µA’·”NŠˆ—p‚³‚ê‚Ä‚¢‚éw‰ä‚ç‡O‘l–¯iŒ´‘è We the Peoplejx‚ðŽQÆ‚µA‚»‚̈ꕔ‚ðŠˆ—p‚µA•Ä‘‚Ì—ðŽj“I”wŒi‚ÉŠî‚¢‚Äì‚ç‚ꂽ‹³Þ‚ðA“ú–{‚Ì•¶–¬‚É‚»‚Á‚ĉü•Ï‚µ‚½B en-copyright= kn-copyright= en-aut-name=KUWABARAToshinori en-aut-sei=KUWABARA en-aut-mei=Toshinori kn-aut-name=ŒKŒ´•q“T kn-aut-sei=ŒKŒ´ kn-aut-mei=•q“T aut-affil-num=1 ORCID= en-aut-name=MIYAMOTOAyuha en-aut-sei=MIYAMOTO en-aut-mei=Ayuha kn-aut-name=‹{–{‚ ‚ä‚Í kn-aut-sei=‹{–{ kn-aut-mei=‚ ‚ä‚Í aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=2 en-affil=Graduate School of Humanities and Social Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»ŠwŒ¤‹†‰ÈŽÐ‰ï•¶‰»ŠwêU en-keyword=Žö‹ÆŠJ”­Œ¤‹† (Lesson Development Research) kn-keyword=Žö‹ÆŠJ”­Œ¤‹† (Lesson Development Research) en-keyword=Œö–¯‰È (Civic Education) kn-keyword=Œö–¯‰È (Civic Education) en-keyword=Œ›–@ŠwK (Constitutional Studies) kn-keyword=Œ›–@ŠwK (Constitutional Studies) en-keyword=—§Œ›Žå‹` (Constitutionalism) kn-keyword=—§Œ›Žå‹` (Constitutionalism) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=139 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practical Issues on Differences in Hours of Attendance as Seen in an Interview of Initial Appointment Child Care Teachers kn-title=‰”C•Ûˆç‹³—@‚ÌŒê‚è‚ÉŒ©‚鉀Ž™‚Ì݉€ŽžŠÔ‚̈Ⴂ‚É‚æ‚éŽÀ‘Hã‚̉ۑè en-subtitle= kn-subtitle= en-abstract=In this paper, we examined practical issues and responses through interviews with novice childcare teachers with a focus on the differences in the length of kindergarteners' attendance time, which characterizes certified childcare centers. As a result, it became obvious that childcare teachers were aware of eight challenges. In addition to the challenge with respect to the gdevelopment of childcare ensuring the continuity of playh described in the gGuidelines for Education and Childcare for Certified Childcare Centers,h furthermore, a new challenge regarding gunderstanding of kindergarteners in consideration of their various attendance time and lifestylesh not described in it was identified. Differences in attendance time due to certification classification inevitably lead to differences in time schedules, locations, and groups during certified childcare centers life. Therefore, in order to clarify what common experiences should be established in certified childcare centers life, what differences in experience should be utilized, and what kind of childcare should be practiced based on the goals set by childcare teachers, a future challenge is to collect and organize good practice examples that have been accumulated so far in certified nurseries and to clarify indicators. kn-abstract=@–{˜_‚Å‚ÍC—c•Û˜AŒgŒ^”F’肱‚Ç‚à‰€‚Ì“Á’¥‚Å‚ ‚鉀Ž™‚Ì݉€ŽžŠÔ‚̈Ⴂ‚ÉÅ“_‚ð“–‚ÄC‰”C•Ûˆç‹³—@‚Ö‚Ì–ÊÚ’²¸‚É‚æ‚èŽÀ‘Hã‚̉ۑè‚ƑΉž‚ɂ‚¢‚ÄŒŸ“¢‚µ‚½B‚»‚ÌŒ‹‰ÊC•Ûˆç‹³—@‚ª‚W‚‚̉ۑè‚ð”FŽ¯‚µ‚Ä‚¢‚邱‚Æ‚ª–¾‚ç‚©‚É‚È‚Á‚½B‚Ü‚½Cw—c•Û˜AŒgŒ^”F’肱‚Ç‚à‰€‹³ˆçE•Ûˆç—v—Ìx‚É‹Lq‚³‚ê‚Ä‚¢‚éu—V‚т̘A‘±«‚ð•Ûá‚·‚é•Ûˆç‚Ì“WŠJv‚ÉŠÖ‚·‚é‰Û‘è‚ɉÁ‚¦‚ÄC‹Lq‚³‚ê‚Ä‚¢‚È‚¢u‘½—l‚È݉€ŽžŠÔ‚ⶊˆŒ`‘Ô‚ðl—¶‚µ‚½‰€Ž™—‰ðv‚ÉŠÖ‚·‚éV‚½‚ȉۑ肪Œ©o‚³‚ꂽB”F’è‹æ•ª‚É‚æ‚é݉€ŽžŠÔ‚̈Ⴂ‚͉€¶Šˆ‚É‚¨‚¯‚鎞ŠÔ“IƒXƒPƒWƒ…[ƒ‹‚âêŠCW’c‚̈Ⴂ‚ð—]‹V‚È‚­‚³‚ê‚éB‚»‚Ì‚½‚ßC•Ûˆç‹³—@‚ªÝ’è‚·‚é‚Ë‚ç‚¢‚ÉŠî‚¢‚½‰€¶Šˆ‚ʼn½‚ð‹¤’ÊŒoŒ±‚Æ‚·‚ׂ«“à—e‚Æ‚µ‚Äݒ肵C‰½‚ðŒoŒ±·‚Æ‚µ‚ÄŠˆ‚©‚µC‚ǂ̂悤‚È•Ûˆç‚ðŽÀ‘H‚·‚é‚©–¾Šm‚É‚·‚ׂ­C‚±‚ê‚Ü‚Å”F’肱‚Ç‚à‰€‚ÅÏ‚Ýd‚Ë‚ç‚ê‚Ä‚«‚½DŽÀ‘H—á‚ðWÏE®—‚µCŽw•W‚𖾎¦‚·‚邱‚Æ‚ª¡Œã‚̉ۑè‚Å‚ ‚éB en-copyright= kn-copyright= en-aut-name=HASUIKazuya en-aut-sei=HASUI en-aut-mei=Kazuya kn-aut-name=˜@ˆä˜a–ç kn-aut-sei=˜@ˆä kn-aut-mei=˜a–ç aut-affil-num=1 ORCID= en-aut-name=KATAYAMAMika en-aut-sei=KATAYAMA en-aut-mei=Mika kn-aut-name=•ÐŽR”ü kn-aut-sei=•ÐŽR kn-aut-mei=”ü aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Health and WelfareC Kawasaki University of Medical Welfare kn-affil=ìèˆã—ÕŸŽƒ‘åŠwˆã—ÕŸŽƒŠw•” affil-num=2 en-affil=Faculty of Education, Graduate School of Science, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=”F’肱‚Ç‚à‰€ (Certified Children Centers) kn-keyword=”F’肱‚Ç‚à‰€ (Certified Children Centers) en-keyword=݉€ŽžŠÔ‚̈Ⴂ (Differences in Hours of Attendance) kn-keyword=݉€ŽžŠÔ‚̈Ⴂ (Differences in Hours of Attendance) en-keyword=ŽÀ‘Hã‚̉ۑè (Issues in Childcare) kn-keyword=ŽÀ‘Hã‚̉ۑè (Issues in Childcare) en-keyword=‰”C•Ûˆç‹³—@ (Initial Appointment Child Care Teachers) kn-keyword=‰”C•Ûˆç‹³—@ (Initial Appointment Child Care Teachers) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=123 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on the Involvement of Community Wind Bands in the Community Development of Wind Band Activities; Can Community Wind Bands Serve as Key Supporters in Community Development of Club Activities? kn-title=‘tŠyŠˆ“®‚Ì’nˆæ“WŠJ‚É‚¨‚¯‚éŽs–¯‘tŠy’c‚ÌŠÖ‚í‚è‚ÉŠÖ‚·‚錤‹† \Žs–¯‘tŠy’c‚Í’nˆæ“WŠJ‚Ì’S‚¢Žè‚ɂȂ蓾‚é‚©\ en-subtitle= kn-subtitle= en-abstract=In the community development of wind band activities, the shortage of instructors and rehearsal spaces has become an urgent issue. This study investigates whether community wind bands can serve as key supporters of community development of childrenf s wind band activities progresses. Based on interviews with 20 community wind bands in Okayama Prefecture and text mining analysis, the study revealed differences in their awareness toward community development of club activities. More proactive bands tended to view providing musical instruction to children and engaging in joint activities positively. On the other hand, concerns about instructional skills, time constraints, and the burden of responsibility were identified as potential obstacles. Furthermore, the findings suggest that utilizing public school facilities could help address the issues of rehearsal space and financial constraints faced by community wind bands. However, disparities among municipalities were also found in the actual implementation of public school facility use systems. kn-abstract=@‘tŠyŠˆ“®‚Ì’nˆæ“WŠJiˆÈ‰ºA’nˆæ“WŠJj‚É‚¨‚¢‚ÄAŽw“±ŽÒ‚⊈“®êŠ‚Ì•s‘«‚Í‹i‹Ù‚̉ۑè‚Å‚ ‚éB–{Œ¤‹†‚ÍA’nˆæ“WŠJ‚ªi‚Þ’†‚ÅAŽs–¯‘tŠy’c‚ª’nˆæ‚ÌŽq‚Ç‚à’B‚Ì‘tŠyŠˆ“®‚ðŽx‚¦‚é’S‚¢Žè‚ƂȂ蓾‚é‚©‚𒲸EŒŸ“¢‚µ‚½B‰ªŽRŒ§“à‚ÌŽs–¯‘tŠy’c20 ’c‘Ì‚Ö‚Ì•·‚«Žæ‚è’²¸‚ƃeƒLƒXƒgƒ}ƒCƒjƒ“ƒO•ªÍ‚ÌŒ‹‰ÊA’nˆæ“WŠJ‚ւ̈ӎ¯‚É‚Í·‚ª‚Ý‚ç‚êAÏ‹É“I‚È’c‘Ì‚Å‚ÍŽq‚Ç‚à’B‚̉‰‘tŽw“±‚⇓¯‚Å‚ÌŠˆ“®‚ðm’è“I‚É‘¨‚¦‚éŒXŒü‚ªŠm”F‚³‚ꂽBˆê•û‚ÅAŽw“±‹Zp‚⎞ŠÔ“I§–ñAÓ”C•‰’S‚Ö‚Ì•sˆÀ‚ªá•Ç‚Æ‚È‚Á‚Ä‚¢‚é‰Â”\«‚ªŽ¦´‚³‚ꂽB‚Ü‚½AŽs–¯‘tŠy’c‚ª•ø‚¦‚銈“®êŠ‚âà­“I‚ȉۑè‚ɑ΂µ‚ÄŒö—§ŠwZŽ{Ý‚ÌŠˆ—p‚ª‚»‚Ì‰ðŒˆ‚ÉŠñ—^‚µ“¾‚é‰Â”\«‚ªŽ¦´‚³‚ꂽBˆê•û‚ÅAŒö—§ŠwZ‚ÌŽ{ÝŠJ•ú‚ɂ‚¢‚Ä‚ÍAŽÀۂ̧“x‰^—p‚É‚¨‚¢‚ÄŽ©Ž¡‘ÌŠÔ‚ÌŠi·‚ª‘¶Ý‚·‚邱‚Æ‚ª–¾‚ç‚©‚Æ‚È‚Á‚½B en-copyright= kn-copyright= en-aut-name=MAKINOKunihiko en-aut-sei=MAKINO en-aut-mei=Kunihiko kn-aut-name=ê –ì–M•F kn-aut-sei=ê –ì kn-aut-mei=–M•F aut-affil-num=1 ORCID= affil-num=1 en-affil=Center for Teacher Education and DevelopmentAOkayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ ‹³ˆç„i‹@\‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[ en-keyword=’nˆæ“WŠJ (community development of club activities) kn-keyword=’nˆæ“WŠJ (community development of club activities) en-keyword=Žs–¯‘tŠy’c (community wind band) kn-keyword=Žs–¯‘tŠy’c (community wind band) en-keyword=’nˆæƒNƒ‰ƒuŠˆ“® (regional club activities) kn-keyword=’nˆæƒNƒ‰ƒuŠˆ“® (regional club activities) en-keyword=ŠwZŽ{ÝŠJ•ú (community use of school facilities) kn-keyword=ŠwZŽ{ÝŠJ•ú (community use of school facilities) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=91 end-page=105 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practical Research on Nurturing the Next Generation of Classical Japanese Instrument Music that Connects the Local and the Global Community (3) . The Potential for Developing Intercultural Competence through Questionnaire Surveys of Elementary and Junior High School Student. kn-title=’nˆæŽÐ‰ï‚ƃOƒ[ƒoƒ‹‚ð‚‚Ȃ®˜aŠyŠí‰¹ŠyŽŸ¢‘ãˆç¬‚ÌŽÀ‘HŒ¤‹†i‚Rj ¬’†Šw¶‚ÌŽ¿–⎆’²¸‚ÉŒ©‚éuˆÙ•¶‰»ŠÔ”\—Ívˆç¬‚̉”\« en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{Œ¤‹†‚ÍCu‚¨‚©‚â‚Ü‘Û˜aŠyŠíŠw¶ƒtƒFƒXƒeƒBƒoƒ‹v‚ÌŽÀ‘H‚É‚¨‚¯‚éCˆÙ•¶‰»ŠÔ”\—͈笂̉”\«‚ɂ‚¢‚ÄCŽQ‰Á‚µ‚½¬’†Šw¶‚ÌŽ¿–⎆’²¸Œ‹‰Ê‚©‚猟“¢‚µ‚½B
@‚»‚ÌŒ‹‰ÊC‚Pj‘ÌŒ±‚ð’Ê‚µ‚ÄŒ`¬‚³‚ꂽV‚½‚È”FŽ¯‚É‚æ‚èC˜aŠyŠí‰¹Šy•¶‰»‚ÆŽ©ŒÈ‚Æ‚ÌŠÖŒW«‚ðÄ”FŽ¯EÄ\’z‚µC˜aŠyŠí‰¹Šy•¶‰»‚Ö‚ÌÏ‹É“I‚ÈŠÖ—^‚ðŽ¦‚·‰¿’l‚¯EˆÓ–¡‚¯‚ªs‚í‚êC“à݉»‚ª‘£‚³‚ꂽ‚±‚ÆC‚Qj‰z‹«•¶‰»‚Æ‚µ‚Ă̘aŠyŠí‰¹Šy•¶‰»‚ɑ΂µ‚ÄCŠJ•ú“IE‘¸d“I‘Ô“x‚ðŽ¦‚µ‚Ä‚¢‚½‚ªCŽ©ŒÈ‚Ì•¶‰»“IƒAƒCƒfƒ“ƒeƒBƒeƒB‚ðˆÓŽ¯‚·‚éŒ_‹@‚Æ‚È‚Á‚½‚±‚ÆC‚Rj˜aŠyŠí‰¹Šy‚Ì‹¤—L‚ð’Ê‚µ‚Ķ‚¶‚½‹¤Š´‚Ìã‚ÉC‘ŠŒÝ—‰ð‚⋦“­ŠÖŒW‚ª\’z‚³‚ê‚Ä‚¢‚½‚±‚ÆC‚Sju•¶‰»‚Ì‹¤—L‚̉”\«‚ɂ‚¢‚Ä‚Ì”FŽ¯v‚ªŒ`¬‚³‚ê‚é‚È‚ÇCƒtƒFƒXƒeƒBƒoƒ‹‚Å‚ÌŒoŒ±‚ªC•¶‰»ŠÏ‚ÌŒ`¬‚ɉe‹¿‚ð—^‚¦‚éŒ_‹@‚Æ‚È‚Á‚Ä‚¢‚½‚±‚ÆC‚ª–¾‚ç‚©‚É‚È‚Á‚½B en-copyright= kn-copyright= en-aut-name=HAYAKAWARinko en-aut-sei=HAYAKAWA en-aut-mei=Rinko kn-aut-name=‘ì—ÏŽq kn-aut-sei=‘ì kn-aut-mei=—ÏŽq aut-affil-num=1 ORCID= en-aut-name=BEPPUYuko en-aut-sei=BEPPU en-aut-mei=Yuko kn-aut-name=•Ê•{—SŽq kn-aut-sei=•Ê•{ kn-aut-mei=—SŽq aut-affil-num=2 ORCID= en-aut-name=YAMAJIMiho en-aut-sei=YAMAJI en-aut-mei=Miho kn-aut-name=ŽR˜H‚Ý‚Ù kn-aut-sei=ŽR˜H kn-aut-mei=‚Ý‚Ù aut-affil-num=3 ORCID= en-aut-name=HANAKUSAYoko en-aut-sei=HANAKUSA en-aut-mei=Yoko kn-aut-name=‰Ô‘—eŽq kn-aut-sei=‰Ô‘ kn-aut-mei=—eŽq aut-affil-num=4 ORCID= en-aut-name=TAKESHITANoriko en-aut-sei=TAKESHITA en-aut-mei=Noriko kn-aut-name=’|‰º‘¥Žq kn-aut-sei=’|‰º kn-aut-mei=‘¥Žq aut-affil-num=5 ORCID= en-aut-name=TAKASUHiromi en-aut-sei=TAKASU en-aut-mei=Hiromi kn-aut-name=ûü{—T”ü kn-aut-sei=ûü{ kn-aut-mei=—T”ü aut-affil-num=6 ORCID= en-aut-name=MIYOSHIKeiko en-aut-sei=MIYOSHI en-aut-mei=Keiko kn-aut-name=ŽODŒ[Žq kn-aut-sei=ŽOD kn-aut-mei=Œ[Žq aut-affil-num=7 ORCID= en-aut-name=SHIMIZUNaoko en-aut-sei=SHIMIZU en-aut-mei=Naoko kn-aut-name=´…®Žq kn-aut-sei=´… kn-aut-mei=®Žq aut-affil-num=8 ORCID= en-aut-name=TOSAChihiro en-aut-sei=TOSA en-aut-mei=Chihiro kn-aut-name=“y²çh kn-aut-sei=“y² kn-aut-mei=çh aut-affil-num=9 ORCID= en-aut-name=NAKAMURA Ai en-aut-sei=NAKAMURA en-aut-mei=Ai kn-aut-name=’†‘ºˆ¤ kn-aut-sei=’†‘º kn-aut-mei=ˆ¤ aut-affil-num=10 ORCID= en-aut-name=HIGUCHIAki en-aut-sei=HIGUCHI en-aut-mei=Aki kn-aut-name=”óŒûˆŸŠó kn-aut-sei=”óŒû kn-aut-mei=ˆŸŠó aut-affil-num=11 ORCID= affil-num=1 en-affil=Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=2 en-affil=Kurashiki City College kn-affil=‘q•~Žs—§’ZŠú‘åŠw affil-num=3 en-affil=Part-time Lecturer at Okayama University kn-affil=‰ªŽR‘åŠw”ñí‹ÎuŽt affil-num=4 en-affil=Research Student at the Joint Graduate School in Science of School Education Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A‡ŠwZ‹³ˆçŠwŒ¤‹†‰È affil-num=5 en-affil=Biwako-Gakuin University kn-affil=‚т킱Šw‰@‘åŠw’ZŠú‘åŠw•” affil-num=6 en-affil=Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=7 en-affil=Research Student at the Joint Graduate School in Science of School Education Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A‡ŠwZ‹³ˆçŠwŒ¤‹†‰È affil-num=8 en-affil=Doctoral Student at the Joint Graduate School in Science of School Education Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A‡ŠwZ‹³ˆçŠwŒ¤‹†‰È affil-num=9 en-affil=Yamaha Corporation kn-affil=ƒ„ƒ}ƒnŠ”Ž®‰ïŽÐŠyŠíŽ–‹Æ–{•” affil-num=10 en-affil=Doctoral Student at the Joint Graduate School in Science of School Education Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A‡ŠwZ‹³ˆçŠwŒ¤‹†‰È affil-num=11 en-affil=Okayama Prefectural School for the Deaf kn-affil=‰ªŽRŒ§—§‰ªŽR˜WŠwZ en-keyword=˜aŠyŠí‰¹Šy (Classical Japanese instrument) kn-keyword=˜aŠyŠí‰¹Šy (Classical Japanese instrument) en-keyword=ˆÙ•¶‰»ŠÔ”\—Í (eIntercultural Competencef) kn-keyword=ˆÙ•¶‰»ŠÔ”\—Í (eIntercultural Competencef) en-keyword=ŽŸ¢‘ãˆç¬ (the next generation) kn-keyword=ŽŸ¢‘ãˆç¬ (the next generation) en-keyword=Ž¿–⎆’²¸ (questionnaire survey) kn-keyword=Ž¿–⎆’²¸ (questionnaire survey) en-keyword=¬Šw¶E’†Šw¶ (elementary and junior high school students) kn-keyword=¬Šw¶E’†Šw¶ (elementary and junior high school students) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=75 end-page=89 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Summer Climate around Germany and the German Lied gIm Fr?hlingh (In Spring) by F. Schubert: A Report of an Interdisciplinary Lesson Practice at the University Leading to the Understanding of Heterogeneous Others kn-title=ƒhƒCƒc•t‹ß‚̉Ă̋CŒó‚ƃVƒ…[ƒxƒ‹ƒg‚̉̋Èst‚Ét ˆÙŽ¿‚È‘¼ŽÒ‚Æ‚Ìo‰ï‚¢‚𑣂·‘åŠw‚Å‚ÌŠwÛ“IŽö‹Æ‚Ì•ñ en-subtitle= kn-subtitle= en-abstract=An interdisciplinary lesson practice for the university students leading to the understanding of heterogeneous others was made on a topic of summer climate and the seasonal feeling around Germany, as a continuing study of Kato et al. (2025). In the lesson practice, details of the climate and seasonal cycle around Germany were firstly explained and the German lied gIm Fr?hlingh (In spring) composed by F. Schubert was appreciated, paying attention to how the scenes and emotions expressed by the lyrics gall summer longh in the 3rd verse of this song might differ whether we imagine the climate around Germany or that around Japan. It seems that the present activity provided an opportunity for the students to perceive the climate environments and seasonal feelings quite different from those familiar to them . However, how to explore the appreciation activities that focus also on the musical expression itself of that song is an interesting remaining problem, in order for the students to capture the summer scenery and emotions which Schubert himself imagined. kn-abstract=@uˆÙŽ¿‚È‘¼ŽÒv‚Ö‚Ìo‰ï‚¢‚𑣂·Žö‹Æ—á‚ÌX‚È‚é’~Ï‚Ì‚½‚ßCƒhƒCƒc•t‹ß‚Ìu‰Äv‚Ì‹CŒó‚Æ‹Gߊ´‚É’–Ú‚µ‚½‹³‰È‰¡’f“I‚ÈŽö‹Æ‚ð‘åŠw‚ÅŽÀ‘H‚µ‚½BŽö‹Æ‚Å‚ÍCƒhƒCƒc•t‹ß‚Ì‹CŒó‚Æ‹G߃TƒCƒNƒ‹‚Ì’†‚Å‚Ìu‰Äv‚Ì“Á’¥‚ð”cˆ¬‚·‚é‚Æ‹¤‚ÉCƒVƒ…[ƒxƒ‹ƒg‚̉̋Èst‚Ét‚ðŠÓÜ‚µ‚½Bst‚Ét‚Ì3 ”Ô‚Ìu‰Ä‚ÌŠÔ‚¶‚イC‚¸‚Á‚Æv‚Æ‚¢‚¤‰ÌŽŒ‚ʼn̂í‚ê‚Ä‚¢‚éîŒi‚â‚ªCƒhƒCƒc•t‹ß‚Æ“ú–{•t‹ß‚ð‘z’肵‚½ê‡‚É‚Ç‚¤ˆá‚¢“¾‚é‚©C‚ÉŠÖ‚·‚éŽóu¶‚Ì‹Lq‚ð•ªÍ‚µ‚½B‚»‚ÌŒ‹‰ÊC“ú–{‚̉Ă̂‰·‘½Ž¼‚Ȋ‹«‚©‚ç‚ÍŒ´Ž‚Ì‚»‚Ì‚à‚Ì‚ª¬—§‚µ“ï‚¢‚ÆŠ´‚¶‚½Šw¶‚à‚¢‚é‚È‚ÇC–{ŽÀ‘H‚ÍCŽ©•ª‚½‚¿‚Ìu“–‚½‚è‘Ov‚Ƃ͈قȂé‹CŒó‚â‹Gߊ´‚É‚à–Ú‚ðŒü‚¯‚é‹@‰ï‚ɂȂ蓾‚½‚Æ‚¢‚¦‚éBˆê•ûC“ú–{‚Æ‚Í‚©‚È‚èˆá‚¤‹CŒó”wŒi‚Ì’†‚ŃVƒ…[ƒxƒ‹ƒg‚ªŽv‚¢•`‚¢‚½‚Å‚ ‚낤îŒiESî‚ÉŽö‹Æ‚Å[‚­”—‚邽‚ß‚ÌC‰¹Šy•\Œ»Ž©‘Ì‚Ö‚Ì“¥‚Ýž‚Ý•û‚ɂ‚¢‚Ä‚àC¡ŒãŒŸ“¢‚·‚é•K—v«‚ªŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=KATOKuranoshin en-aut-sei=KATO en-aut-mei=Kuranoshin kn-aut-name=‰Á“¡“àåUi kn-aut-sei=‰Á“¡ kn-aut-mei=“àåUi aut-affil-num=1 ORCID= en-aut-name=NAGAOKAIsao en-aut-sei=NAGAOKA en-aut-mei=Isao kn-aut-name=’·‰ªŒ÷ kn-aut-sei=’·‰ª kn-aut-mei=Œ÷ aut-affil-num=2 ORCID= en-aut-name=KATOHaruko en-aut-sei=KATO en-aut-mei=Haruko kn-aut-name=‰Á“¡°Žq kn-aut-sei=‰Á“¡ kn-aut-mei=°Žq aut-affil-num=3 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=3 en-affil=Faculty of Education, Gufu Shotoku Gakuen University (Former affiliation) kn-affil=Œ³@Šò•Œ¹“¿Šw‰€‘åŠw‹³ˆçŠw•” en-keyword=‹CŒó‚Ɖ¹Šy kn-keyword=‹CŒó‚Ɖ¹Šy en-keyword=ƒhƒCƒc•t‹ß‚̉Ă̋CŒó‚Æ‹Gߊ´ kn-keyword=ƒhƒCƒc•t‹ß‚̉Ă̋CŒó‚Æ‹Gߊ´ en-keyword=‹CŒó‚Æ•¶‰»—‰ð‚ÌŠwÛ“IESD‹³Žt‹³ˆç kn-keyword=‹CŒó‚Æ•¶‰»—‰ð‚ÌŠwÛ“IESD‹³Žt‹³ˆç en-keyword=ˆÙŽ¿‚È‘¼ŽÒ‚Ö‚Ì—‰ð kn-keyword=ˆÙŽ¿‚È‘¼ŽÒ‚Ö‚Ì—‰ð END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=61 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Physical Activity Levels During Soccer Matches Among Junior High School Students Focusing on Position and Physical/Fitness Characteristics kn-title=’†Šw¶‚ð‘ÎÛ‚Æ‚µ‚½ƒTƒbƒJ[ŽŽ‡’†‚Ìg‘ÌŠˆ“®—Ê‚ÉŠÖ‚·‚錤‹† `ƒ|ƒWƒVƒ‡ƒ“‚Æg‘ÌE‘Ì—Í“Á«‚É’…–Ú‚µ‚Ä` en-subtitle= kn-subtitle= en-abstract=We compared physical and fitness characteristics by soccer position using results from the New Physical Fitness Test administered to 30 junior high school students. Additionally, we compared differences in physical activity levels by position during soccer matches while wearing LC devices. The results showed no significant differences in physical or fitness characteristics between positions. However, significant differences were observed between positions in step count and the proportion of time spent in physical activity by intensity level. This revealed that physical activity levels during soccer matches differ between positions even among junior high school students, clarifying position-specific characteristics in soccer. It also suggested the usefulness of evaluating physical activity levels during matches over time. kn-abstract=@’†Šw¶34l‚ð‘ÎÛ‚Æ‚µCg‘ÌE‘Ì—Í“Á«‚ƃTƒbƒJ[ŽŽ‡’†‚Ìg‘ÌŠˆ“®—ʂɂ‚¢‚ÄCƒ|ƒWƒVƒ‡ƒ“‚É’…–Ú‚µ‚Ä”äŠrEŒŸ“¢‚µ‚½D‚»‚ÌŒ‹‰ÊCg‘ÌE‘Ì—Í“Á«‚ɂ‚¢‚Ă̓|ƒWƒVƒ‡ƒ“ŠÔ‚É—LˆÓ‚È·‚Í”F‚ß‚ç‚ê‚È‚©‚Á‚½D•à”‚ł̓|ƒWƒVƒ‡ƒ“ŠÔ‚Å—LˆÓ·‚ª”F‚ß‚ç‚êCƒ‰ƒCƒgƒTƒCƒhƒoƒbƒN‚ª­‚È‚­CƒZƒ“ƒ^[ƒ~ƒbƒhƒtƒBƒ‹ƒ_[‚ª‚‚©‚Á‚½D‹­“x•Êg‘ÌŠˆ“®—ÊŽžŠÔ‚ÌŠ„‡‚ł̓|ƒWƒVƒ‡ƒ“ŠÔ‚Å—LˆÓ·‚ª”F‚ß‚ç‚êCƒ‰ƒCƒgƒTƒCƒhƒoƒbƒN‚ª’á‚­CƒZƒ“ƒ^[ƒ~ƒbƒhƒtƒBƒ‹ƒ_[‚ª‚‚©‚Á‚½DˆÈã‚Ì‚±‚Æ‚©‚çC–{Œ¤‹†‚Ì‘ÎÛ’†Šw¶‚ł̓|ƒWƒVƒ‡ƒ“ŠÔ‚Åg‘ÌE‘Ì—Í“Á«‚É‚Í—LˆÓ·‚ª”F‚ß‚ç‚ê‚È‚¢‚ªCƒTƒbƒJ[ŽŽ‡’†‚Ìg‘ÌŠˆ“®—ʂł̓|ƒWƒVƒ‡ƒ“ŠÔ‚Å·‚ª¶‚¶‚邱‚Æ‚ªŽ¦´‚³‚ꂽD en-copyright= kn-copyright= en-aut-name=NATSUMEDATakaaki en-aut-sei=NATSUMEDA en-aut-mei=Takaaki kn-aut-name=ž¥“c‘¸‹M kn-aut-sei=ž¥“c kn-aut-mei=‘¸‹M aut-affil-num=1 ORCID= en-aut-name=ADACHIMinoru en-aut-sei=ADACHI en-aut-mei=Minoru kn-aut-name=‘«—§–« kn-aut-sei=‘«—§ kn-aut-mei=–« aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È affil-num=2 en-affil=Okayama University Graduate School of Education kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=ƒTƒbƒJ[ (Soccer) kn-keyword=ƒTƒbƒJ[ (Soccer) en-keyword=’†Šw¶ (Junior High School Students) kn-keyword=’†Šw¶ (Junior High School Students) en-keyword=‰Á‘¬“xŒv (Accelerometer) kn-keyword=‰Á‘¬“xŒv (Accelerometer) en-keyword=V‘̗̓eƒXƒg (New Physical Fitness Test) kn-keyword=V‘̗̓eƒXƒg (New Physical Fitness Test) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=15 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Critical Reading Instruction of Expository Text that Promotes Reflecting: Practice for First-year Student at High School kn-title=à–¾“I•¶Í‚ÌŽw“±‚É‚¨‚¯‚éu“àÈv‚𑣂·”á”»“I“Ç‚Ý \‚“™ŠwZ‚P”N¶‚ð‘ÎÛ‚Æ‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract=@Critical reading is an essential skill at present time and is included in government guidelines for teaching. Although recent research on teaching critical reading has been conducted, there have been criticisms that lack of consideration of content value and understanding context within society. There are also calls for critical reading that focuses on the perspective of greflecth . Therefore, this paper developed a lesson that encourages students not only critically read the text, but also critically consider (reflect on) their own ideas. As a measure to achieve this, incorporated activities such as comparing two teaching materials that contained multiple social perceptions, exchanging opinions from opposing perspectives, writing an evaluation of the materials, and having the students themselves evaluate their own writing (their own reading). Analysis of the studentsf writings shows that, while some students didnf t reach conscious reflection, about 60% of studentsf writings showed changes. And then it suggests that the methods used were effective. kn-abstract=@”á”»“I“Ç‚Ý‚ÍCŒ»‘ã‚Å‚ÍŒ‡‚©‚¹‚È‚¢”\—Í‚Å‚ ‚èCŠwKŽw“±—v—Ì‚É‚à–¾‹L‚³‚ê‚Ä‚¢‚éB‹ß”NC”á”»“I“Ç‚Ý‚ÌŽw“±‚ÉŠÖ‚·‚錤‹†‚ª‚È‚³‚ê‚Ä‚¢‚é‚à‚Ì‚ÌC“à—e“I‚ȉ¿’l‚ÌŒŸ“¢‚âŽÐ‰ï“I‚È•¶–¬‚Ì‚È‚©‚Å‘¨‚¦‚邱‚Æ‚ªŠó”–‚¾‚Æ‚·‚éŽw“E‚âCu”½È«v‚Æ‚¢‚¤ŠÏ“_‚É’…–Ú‚µ‚½”á”»“I“Ç‚Ý‚ð‹‚ß‚éº‚à‚ ‚éB‚»‚±‚ÅC–{e‚Å‚ÍC•¶Í‚»‚Ì‚à‚Ì‚ð”á”»“I‚É“Ç‚Þ‚¾‚¯‚Å‚È‚­CŽ©g‚ÌŽ‚Á‚Ä‚¢‚él‚¦‚ð‚à”á”»“I‚É‘¨‚¦‚éi“àÈ‚·‚éj‚±‚Ƃ𑣂·Žö‹Æ‚ðŠJ”­‚µ‚½B‚»‚ÌŽè—§‚Ä‚Æ‚µ‚ÄC•¡”‚̎Љï”FŽ¯‚ª‘¶Ý‚·‚é“ñ‚‚̋³Þ‚Ì“Ç‚Ý”ä‚ׂ½‚¤‚¦‚ÅC‘Η§‚·‚闧ꂩ‚ç‚̈ӌ©ŒðŠ·‚ðs‚¤‚±‚Æ‚âC‹³Þ‚ɑ΂·‚é•]‰¿‚Ì‹LqC‚»‚Ì‹LqiŽ©ŒÈ‚Ì“Ç‚Ýj‚ðŠwKŽÒŽ©g‚ª•]‰¿‚·‚é‚Æ‚¢‚Á‚½Šˆ“®‚ðŽæ‚è“ü‚ꂽBŠwKŽÒ‚Ì‹Lq‚Ì•ªÍ‚©‚ç‚ÍCˆÓŽ¯“I‚È“àÈ‚ÉŽŠ‚ç‚È‚©‚Á‚½ŠwKŽÒ‚àŒ©Žó‚¯‚ç‚ꂽ‚à‚Ì‚ÌC–ñ‚UŠ„‚ÌŠwKŽÒ‚Ì‹Lq‚É‚Í•Ï—e‚ªŒ©‚ç‚êC—p‚¢‚½Žè—§‚Ä‚ÍŒø‰Ê‚ª‚ ‚Á‚½‚Æ„‘ª‚Å‚«‚邱‚Æ‚ðŽw“E‚µ‚½B en-copyright= kn-copyright= en-aut-name=SAISHOYumi en-aut-sei=SAISHO en-aut-mei=Yumi kn-aut-name=Å‘Š—L–¢ kn-aut-sei=Å‘Š kn-aut-mei=—L–¢ aut-affil-num=1 ORCID= en-aut-name=IKEDAMasafumi en-aut-sei=IKEDA en-aut-mei=Masafumi kn-aut-name=’r“c‹§Žj kn-aut-sei=’r“c kn-aut-mei=‹§Žj aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education (Professional Degree Corse), Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=”½È« (reflectiveness) kn-keyword=”½È« (reflectiveness) en-keyword=îˆÓ“I«Œü (affective disposition) kn-keyword=îˆÓ“I«Œü (affective disposition) en-keyword=•¡”ƒeƒNƒXƒg (multiple texts) kn-keyword=•¡”ƒeƒNƒXƒg (multiple texts) en-keyword=uŒ»‘ã‚Ì‘Œêv (gContemporary Japanese Languageh) kn-keyword=uŒ»‘ã‚Ì‘Œêv (gContemporary Japanese Languageh) en-keyword=¶•¨‘½—l« (biodiversity) kn-keyword=¶•¨‘½—l« (biodiversity) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=1 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Preschool Teachersf Strategies and Practical Challenges in Supporting the School Enrollment of Foreign Children kn-title=ŠO‘l—cŽ™‚ÌAŠwŽx‰‡‚É‚¨‚¯‚é•ÛˆçŽm‚ÌH•v‚ÆŽÀ‘H“I‰Û‘è en-subtitle= kn-subtitle= en-abstract=This study aimed to clarify the specific practices and challenges faced by preschool teachers in supporting foreign children at the time of school enrollment. Semi-structured interviews were conducted with two preschool teachers who had experience in supporting foreign children, and qualitative analysis using SCAT was applied to organize the support provided to both children and their parents. The results revealed that, in terms of language support, teachers utilized visual aids and simplified Japanese, while in cultural support they sought to balance family culture with the culture of the preschool. Regarding developmental support, the importance of fostering non-cognitive skills and collaborating with medical institutions was highlighted. In parent support, participatory involvement and careful explanations were practiced; however, challenges remained in providing institutional information and establishing collaboration with local governments. Based on these findings, it is necessary to establish a regional collaborative system that can provide institutional support for families with multicultural backgrounds, standardize the provision of information, and build practical mechanisms to connect with Japanese language education resources, so that support does not rely solely on the individual efforts of preschool teachers. kn-abstract=@–{Œ¤‹†‚ÍCŠO‘l—cŽ™‚ªAŠwŠú‚É’¼–Ê‚·‚颓ï‚ɑΉž‚·‚邽‚ßC•ÛˆçŽm‚ªs‚Á‚Ä‚¢‚é‹ï‘Ì“I‚È•ÛˆçŽÀ‘H‚É‚¨‚¯‚éŽx‰‡‚ÌH•v‚Ɖۑè‚𖾂炩‚É‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚½BŠO‘l—cŽ™‚ÌŽx‰‡ŒoŒ±‚ð—L‚·‚é•ÛˆçŽm2 –¼‚É”¼\‘¢‰»ƒCƒ“ƒ^ƒrƒ…[‚ðs‚¢CSCAT ‚ð—p‚¢‚½Ž¿“I•ªÍ‚É‚æ‚èC—cŽ™‚¨‚æ‚Ñ•ÛŒìŽÒ‚Ö‚ÌŽx‰‡“à—e‚ð®—‚µ‚½B‚»‚ÌŒ‹‰ÊCŒ¾Œê–Ê‚Å‚ÍŽ‹Šo“IŽx‰‡‚â‚₳‚µ‚¢“ú–{Œê‚ðŠˆ—p‚µC•¶‰»–ʂł͉ƒ땶‰»‚Æ“ú–{‚̉€•¶‰»‚Ì’²®‚ªs‚í‚ê‚Ä‚¢‚½B”­’BŽx‰‡‚É‚¨‚¢‚Ä‚ÍC”ñ”F’m“IƒXƒLƒ‹‚̈笂âˆã—Ë@ŠÖ‚Ƃ̘AŒg‚Ì•K—v«‚ªŽw“E‚³‚ꂽB•ÛŒìŽÒŽx‰‡‚Å‚ÍCŽQ‰ÁŒ^‚ÌŠÖ‚í‚è‚â’š”J‚Èà–¾‚ªŽÀ‘H‚³‚ê‚Ä‚¢‚½‚ªC§“xî•ñ‚Ì’ñ‹Ÿ‚âs­‚Ƃ̘AŒg‚ɂ͉ۑ肪Žc‚³‚ꂽB‚±‚ê‚ç‚ÌŒ‹‰Ê‚𓥂܂¦C¡Œã‚Í•ÛˆçŽm‚̌•ʓI“w—͂Ɉˑ¶‚µ‚È‚¢‚½‚ß‚É‚àC‘½•¶‰»”wŒi‚ð‚à‚‰ƒë‚Ö‚ÌŽx‰‡‚ð§“x“I‚ÉŽx‚¦‚é’nˆæ˜AŒg‘̧‚Ì®”õ‚âCî•ñ’ñ‹Ÿ‚Ì•W€‰»C“ú–{Œê‹³ˆçŽ‘Œ¹‚Æ‚ÌÚ‘±‚ð}‚éŽÀ‘H“IŽd‘g‚Ý‚Ì\’z‚ª‹‚ß‚ç‚ê‚éB en-copyright= kn-copyright= en-aut-name=CHENYiwen en-aut-sei=CHEN en-aut-mei=Yiwen kn-aut-name=’ˆ˕¶ kn-aut-sei=’ kn-aut-mei=ˆË•¶ aut-affil-num=1 ORCID= en-aut-name=YANAGISAWAKazuki en-aut-sei=YANAGISAWA en-aut-mei=Kazuki kn-aut-name=–öàV‰ÀŒŽ kn-aut-sei=–öàV kn-aut-mei=‰ÀŒŽ aut-affil-num=2 ORCID= en-aut-name=REN Xinyu en-aut-sei=REN en-aut-mei= Xinyu kn-aut-name=”Cc˜° kn-aut-sei=”C kn-aut-mei=c˜° aut-affil-num=3 ORCID= en-aut-name=YOSHITOSHIMunehisa en-aut-sei=YOSHITOSHI en-aut-mei=Munehisa kn-aut-name=‹g—˜@‹v kn-aut-sei=‹g—˜ kn-aut-mei=@‹v aut-affil-num=4 ORCID= affil-num=1 en-affil=The Joint Graduate School (Ph.D. Program) in Science of School Education, Hyogo University of Teacher, Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A‡ŠwZ‹³ˆçŠwŒ¤‹†‰È”ŽŽm‰Û’ö affil-num=2 en-affil=Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È affil-num=3 en-affil=Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È affil-num=4 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=ŠO‘l—cŽ™ (foreign preschool children) kn-keyword=ŠO‘l—cŽ™ (foreign preschool children) en-keyword=AŠw (school enrollment) kn-keyword=AŠw (school enrollment) en-keyword=•ÛˆçŽm (preschool teachers) kn-keyword=•ÛˆçŽm (preschool teachers) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽR‘åŠw‹³ˆç„i‹@\ ‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[‹I—v ‘æ16† ‘S•¶iˆêŠ‡ƒ_ƒEƒ“ƒ[ƒh—pj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=3 article-no= start-page=55 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Low Temperature Formation of Dense Yttria-Stabilized Zirconia Layer Using Hot Isostatic Pressing kn-title=”MŠÔÃ…ˆ³‰Áˆ³–@‚ð—p‚¢‚½ƒCƒbƒgƒŠƒAˆÀ’艻ƒWƒ‹ƒRƒjƒAãk–§‘w‚̒ቷŒ`¬ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The sintering conditions using hot isostatic press (HIP) of yttria-stabilized zirconia (YSZ) were investigated to obtain a dense YSZ layer at low sintering temperature such as 1000‹C for an electrolyte of metal-supported solid oxide fuel cell. It was found that a dense YSZ pellet with relative density of 93% could be obtained under a sintering condition of 1000‹C-10 hours with HIP in 195 MPa. On the other hand, in X-ray diffraction analysis of the dense YSZ pellet, peaks of the monoclinic phase were slightly detected in addition to peaks of the cubic phase. From energy dispersive X-ray spectroscopy analysis, a small amount of boron was detected in the dense YSZ pellet. It is considered that the YSZ crystalline phase transformation of cubic to monoclinic phase was occurred by the boron diffusion from the diffusion barrier coating of metal foil capsule used for the HIP. en-copyright= kn-copyright= en-aut-name=MANABEKyohei en-aut-sei=MANABE en-aut-mei=Kyohei kn-aut-name=^“ç‹•½ kn-aut-sei=^“ç kn-aut-mei=‹•½ aut-affil-num=1 ORCID= en-aut-name=ECHIGOMitsuaki en-aut-sei=ECHIGO en-aut-mei=Mitsuaki kn-aut-name=‰zŒã–žH kn-aut-sei=‰zŒã kn-aut-mei=–žH aut-affil-num=2 ORCID= en-aut-name=KISHIMOTOAkira en-aut-sei=KISHIMOTO en-aut-mei=Akira kn-aut-name=ŠÝ–{º kn-aut-sei=ŠÝ–{ kn-aut-mei=º aut-affil-num=3 ORCID= affil-num=1 en-affil=Osaka Gas Co. Ltd. kn-affil=‘åãƒKƒXiŠ”j affil-num=2 en-affil=Osaka Gas Co. Ltd. kn-affil=‘åãƒKƒXiŠ”j affil-num=3 en-affil=Institute of Academic and Research, Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŠÂ‹«¶–½Ž©‘R‰ÈŠwŠwˆæ en-keyword=dense yttria-stabilized zirconia kn-keyword=dense yttria-stabilized zirconia en-keyword=hot isostatic press kn-keyword=hot isostatic press en-keyword=low sintering temperature kn-keyword=low sintering temperature en-keyword=electrolyte kn-keyword=electrolyte en-keyword=metal-supported solid oxide fuel cell kn-keyword=metal-supported solid oxide fuel cell END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page=75 end-page=78 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Ž‘—¿ : 2023”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page=13 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰^‰c : 2023”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page=7 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ŽŽŒ±Œ¤‹† : 2023”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page=i end-page=i dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=˜ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ˆÀꌒˆê˜Y kn-aut-sei=ˆÀê kn-aut-mei=Œ’ˆê˜Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw”_Šw•”•‘®ŽR—zŒ—ƒtƒB[ƒ‹ƒh‰ÈŠwƒZƒ“ƒ^[ END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=1 article-no= start-page=bbag021 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=SGCRNA: spectral clustering-guided co-expression network analysis without scale-free constraints for multi-omic data en-subtitle= kn-subtitle= en-abstract= kn-abstract=Weighted gene co-expression network analysis (WGCNA) is among the most widely employed methods in bioinformatics. WGCNA enables the identification of gene clusters (modules) exhibiting correlated expression patterns, the association of these modules with traits, and the exploration of candidate biomarker genes by focusing on hub genes within the modules. WGCNA has been successfully applied in diverse biological contexts. However, conventional algorithms manifest three principal limitations: the assumption of scale-free topology, the requirement for parameter tuning, and the neglect of regression line slopes. These limitations are addressed by SGCRNA. SGCRNA provides Julia functions for the analysis of co-expression networks derived from various types of biological data, such as gene expression data. The Julia packages and their source code are freely available at https://github.com/C37H41N2O6/SGCRNAs.jl. en-copyright= kn-copyright= en-aut-name=OsoneTatsunori en-aut-sei=Osone en-aut-mei=Tatsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakaoTomoka en-aut-sei=Takao en-aut-mei=Tomoka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OtakeShigeo en-aut-sei=Otake en-aut-mei=Shigeo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakaradaTakeshi en-aut-sei=Takarada en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=co-expression network analysis kn-keyword=co-expression network analysis en-keyword=multi-omics kn-keyword=multi-omics en-keyword=spectral clustering kn-keyword=spectral clustering END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=“Še‹K’öE‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=59 end-page=68 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practical BIZEN Device Design Course Activity Report in Fiscal 2025 kn-title=2025 ”N“xŽŸ¢‘ãˆã—Ë@ŠíŠJ”­lވ笃vƒƒOƒ‰ƒ€ BIZEN ƒfƒoƒCƒXƒfƒUƒCƒ“ƒR[ƒX‚ÌŽæ‚è‘g‚Ý en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TSUZUKITsuneaki en-aut-sei=TSUZUKI en-aut-mei=Tsuneaki kn-aut-name=“s’zí–¾ kn-aut-sei=“s’z kn-aut-mei=í–¾ aut-affil-num=1 ORCID= en-aut-name=UCHIDADaisuke en-aut-sei=UCHIDA en-aut-mei=Daisuke kn-aut-name=“à“c‘å•ã kn-aut-sei=“à“c kn-aut-mei=‘å•ã aut-affil-num=2 ORCID= en-aut-name=KISHIMOTOToshio en-aut-sei=KISHIMOTO en-aut-mei=Toshio kn-aut-name=ŠÝ–{r•v kn-aut-sei=ŠÝ–{ kn-aut-mei=r•v aut-affil-num=3 ORCID= en-aut-name=SENGOKUYoshinari en-aut-sei=SENGOKU en-aut-mei=Yoshinari kn-aut-name=åΊì–ç kn-aut-sei=åÎ kn-aut-mei=Šì–ç aut-affil-num=4 ORCID= en-aut-name=KORENAGAToshio en-aut-sei=KORENAGA en-aut-mei=Toshio kn-aut-name=ˆÉ‰ir—Y kn-aut-sei=ˆÉ‰i kn-aut-mei=r—Y aut-affil-num=5 ORCID= en-aut-name=HITOBEYu en-aut-sei=HITOBE en-aut-mei=Yu kn-aut-name=l•”—F kn-aut-sei=l•” kn-aut-mei=—F aut-affil-num=6 ORCID= en-aut-name=YOSHIBAYasuyuki en-aut-sei=YOSHIBA en-aut-mei=Yasuyuki kn-aut-name=‹g—t‹±s kn-aut-sei=‹g—t kn-aut-mei=‹±s aut-affil-num=7 ORCID= en-aut-name=SAKURAIJun en-aut-sei=SAKURAI en-aut-mei=Jun kn-aut-name=ŸNˆä~ kn-aut-sei=ŸNˆä kn-aut-mei=~ aut-affil-num=8 ORCID= affil-num=1 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=2 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=3 en-affil=Organization for Research and Innovation Strategy, Okayama University kn-affil=‰ªŽR‘åŠw Œ¤‹†EƒCƒmƒx[ƒVƒ‡ƒ“‹¤‘n‹@\ affil-num=4 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=5 en-affil=Organization for Research and Innovation Strategy, Okayama University kn-affil=‰ªŽR‘åŠw Œ¤‹†EƒCƒmƒx[ƒVƒ‡ƒ“‹¤‘n‹@\ affil-num=6 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=7 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=8 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=49 end-page=57 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Advanced Hospital Training Activities in Fiscal 2025 kn-title=2025 ”N“x‚É‚¨‚¯‚éuæi•a‰@ŽÀKv‚ÌŽæ‚è‘g‚Ý en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MORITAMizuki en-aut-sei=MORITA en-aut-mei=Mizuki kn-aut-name=X“cŽ÷ kn-aut-sei=X“c kn-aut-mei=Ž÷ aut-affil-num=1 ORCID= en-aut-name=MAGARIMasaki en-aut-sei=MAGARI en-aut-mei=Masaki kn-aut-name=‹È³Ž÷ kn-aut-sei=‹È kn-aut-mei=³Ž÷ aut-affil-num=2 ORCID= en-aut-name=WangJin en-aut-sei=Wang en-aut-mei=Jin kn-aut-name=‰¤? kn-aut-sei=‰¤ kn-aut-mei=? aut-affil-num=3 ORCID= en-aut-name=WATANABEToyohiko en-aut-sei=WATANABE en-aut-mei=Toyohiko kn-aut-name=“nç³–L•F kn-aut-sei=“nç³ kn-aut-mei=–L•F aut-affil-num=4 ORCID= en-aut-name=OITAMasataka en-aut-sei=OITA en-aut-mei=Masataka kn-aut-name=‹ˆ“c«c kn-aut-sei=‹ˆ“c kn-aut-mei=«c aut-affil-num=5 ORCID= en-aut-name=HARADANahoko en-aut-sei=HARADA en-aut-mei=Nahoko kn-aut-name=Œ´“c“Þ•äŽq kn-aut-sei=Œ´“c kn-aut-mei=“Þ•äŽq aut-affil-num=6 ORCID= en-aut-name=SHISHIDOKeisuke en-aut-sei=SHISHIDO en-aut-mei=Keisuke kn-aut-name=Ž³ŒËŒ\‰î kn-aut-sei=Ž³ŒË kn-aut-mei=Œ\‰î aut-affil-num=7 ORCID= affil-num=1 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=2 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=3 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=4 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=5 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=6 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=7 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=39 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Narrative Review on Motivation and Evaluation of Community Residents regarding Advance Care Planning in Japan kn-title=‚킪‘‚̃Aƒhƒoƒ“ƒXEƒPƒAEƒvƒ‰ƒ“ƒjƒ“ƒO‚É‚¨‚¯‚é’nˆæZ–¯‚Ö‚Ì“®‹@‚¯‚Æ•]‰¿‚ɂ‚¢‚Ẵiƒ‰ƒeƒBƒuEƒŒƒrƒ…[ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HASUITakako en-aut-sei=HASUI en-aut-mei=Takako kn-aut-name=˜@ˆä‹MŽq kn-aut-sei=˜@ˆä kn-aut-mei=‹MŽq aut-affil-num=1 ORCID= en-aut-name=NAKAYAMANaoko en-aut-sei=NAKAYAMA en-aut-mei=Naoko kn-aut-name=’†ŽR’¼Žq kn-aut-sei=’†ŽR kn-aut-mei=’¼Žq aut-affil-num=2 ORCID= affil-num=1 en-affil=Japanese Red Cross Hokkaido College of Nursing kn-affil=“ú–{Ô\Žš–kŠC“¹ŠÅŒì‘åŠw affil-num=2 en-affil=Kanagawa University of Human Services kn-affil=_“Þ쌧—§•ÛŒ’•ŸŽƒ‘åŠw END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=17 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Patient Participation in Shared Decision-Making: A Consideration of Aspects and Challenges kn-title=Shared Decision Making ‚É‚¨‚¯‚銳ŽÒŽQ‰Á‚Ì”‘Š‚Ɖۑè‚ÌlŽ@ en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper traces the historical development of decision-making models in healthcare while exploring the meaning and practical significance of gpatient participationh within the shared decision-making (SDM) framework. SDM is a recommended approach to clinical decision-making that emphasizes mutual information sharing and deliberation between physicians and patients. Traditional models often assume that patients can clearly articulate their values, preferences, and treatment goals. However, in actual clinical settings, particularly in cases of serious illness or life-threatening situations, patients frequently face emotional distress and psychological burdens, which can hinder their active participation in decision-making and the expression of their preferences. Based on SDM theory and practice reports, this study argues that SDM should not be viewed merely as a process that promotes patient choice. Even when patients choose not to actively participate and ultimately delegate decisions to healthcare providers or family members, such a choice can represent autonomous decision-making if it arises through meaningful communication and mutual understanding. This perspective calls for a more comprehensive and flexible interpretation of patient participation in SDM practice. en-copyright= kn-copyright= en-aut-name=YOSHIDAMiho en-aut-sei=YOSHIDA en-aut-mei=Miho kn-aut-name=‹g“c”ü•ä kn-aut-sei=‹g“c kn-aut-mei=”ü•ä aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems Okayama University kn-affil=‘—§‘åŠw–@l‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŒ¤‹†Šwˆæ en-keyword=Shared Decision-Making kn-keyword=Shared Decision-Making en-keyword=Patient Participation kn-keyword=Patient Participation en-keyword=Physician?Patient Relationship kn-keyword=Physician?Patient Relationship END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=7 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Preliminary Study on Nursing Care Technology: A Case Study of Elderly Care kn-title=‰îŒì‹Zp˜_ŽŽ˜_\‚—îŽÒ‰îŒì‚ðŽ–—á‚Æ‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the first part of this paper, it was confirmed that the term gkaigoh (nursing care) was coined and its meaning defined during discussions on enacting social welfare legislation accompanying societal aging, as the care aspect was being gdifferentiatedh from the gfamilyfs health and welfare functions.h The paper also examined how the term gkaigo gijutsuh(nursing care technique) has been defined and used. In the latter part, based on the authorfs own definition of gkaigo gijutsuh(nursing care technology), an attempt was made to analyze examples of technology utilization in nursing care settings, focusing on papers published in specialized welfare and nursing care technology journals. Through this preliminary study, it was shown that the authorfs definition of gnursing care technologyh clearly distinguishes between the means for care activities?such as welfare equipment?and the care recipients and caregivers who make use of them, and that this definition is useful for grasping the essence of challenges in nursing care settings. en-copyright= kn-copyright= en-aut-name=YOSHIBAYasuyuki en-aut-sei=YOSHIBA en-aut-mei=Yasuyuki kn-aut-name=‹g—t‹±s kn-aut-sei=‹g—t kn-aut-mei=‹±s aut-affil-num=1 ORCID= affil-num=1 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ en-keyword=Nursing Care Technology kn-keyword=Nursing Care Technology en-keyword=Elderly Care kn-keyword=Elderly Care en-keyword=welfare equipment kn-keyword=welfare equipment END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=1 article-no= start-page=8840 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260317 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Tribolium castaneum with longer duration of tonic immobility have more variations corresponding to the human Parkinsonfs disease genomic region en-subtitle= kn-subtitle= en-abstract= kn-abstract=Parkinsonfs disease (PD) is a common neurodegenerative syndrome characterized by the loss of dopaminergic neurons and is also a progressive neurodegenerative disorder that is characterized by dopamine deficiency. We established strains artificially selected for longer and shorter durations of tonic immobility, an antipredator behavior that has received much attention recently, in the red flour beetle, Tribolium castaneum, a model insect species for molecular analyses different from Drosophila melanogaster. Previous studies have shown that the long strains (L-strain) have significantly lower levels of dopamine expression in the brain than the short strains (S-strain) and that they have an abnormal pattern of locomotor activity. Furthermore, previous studies have shown that administering dopamine to L-strain beetles reduces the duration of tonic immobility. Transcriptome analysis of brain and thorax of the L- and S-strains also showed differences in mRNA expression of genes involved in dopamine synthesis and tyrosine metabolism. These results indicate that the phenotype and molecular basis of the L-strain are similar to those of Parkinsonfs syndrome symptoms. In order to establish a link between T. castaneum and PD, we compared the DNA sequences of the L- and S-strains to human genes affecting dopaminergic pathways. The DNA comparison revealed many mutated regions in these genes in the L-strain. We discuss the relationship between dopaminergic pathway genes and PD-like phenotypes across humans, Drosophila, and the red flour beetle. en-copyright= kn-copyright= en-aut-name=TanakaKeisuke en-aut-sei=Tanaka en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SasakiKen en-aut-sei=Sasaki en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YajimaShunsuke en-aut-sei=Yajima en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyatakeTakahisa en-aut-sei=Miyatake en-aut-mei=Takahisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=NODAI Genome Research Center, Tokyo University of Agriculture kn-affil= affil-num=2 en-affil=Graduate School of Agriculture, Tamagawa University kn-affil= affil-num=3 en-affil=NODAI Genome Research Center, Tokyo University of Agriculture kn-affil= affil-num=4 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=1 article-no= start-page=42 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=2026 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Biosensing method of growth diagnosis in the forced culture of strawberries \Development of crop-identification algorithms\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=An image-processing algorithm for identifying individual crops is developed for labor-savings and time-series biological information collection. Information including the leaf development frequency are diagnostic indicators of strawberry growth. The algorithm is designed for drones in greenhouses that cannot acquire location information using the global navigation satellite system (GNSS). Drones fly over crop rows and sequentially assign identification numbers (IDs) to crops. Object-detection artificial intelligence (AI) is used to estimate the crop zone, and the ID is based on the crops number difference between frames. The previous misdetection rate was 1.06 %, failing to identify crops, which decreases to 0.31 % using the proposed algorithm. Furthermore, because there are no failures in consecutive frames, IDs are assigned to all crops correctly. en-copyright= kn-copyright= en-aut-name=TSUBOTAShogo en-aut-sei=TSUBOTA en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NAMBAKazuhiko en-aut-sei=NAMBA en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KASEIShota en-aut-sei=KASEI en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FUKATSUTokihiro en-aut-sei=FUKATSU en-aut-mei=Tokihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Institute of Agricultural Machinery, National Agriculture and Food Research Organization kn-affil= affil-num=2 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Institute of Agricultural Machinery, National Agriculture and Food Research Organization kn-affil= affil-num=4 en-affil=Institute of Agricultural Machinery, National Agriculture and Food Research Organization kn-affil= en-keyword=strawberry kn-keyword=strawberry en-keyword=forcing culture kn-keyword=forcing culture en-keyword=image-processing kn-keyword=image-processing en-keyword=object-detection kn-keyword=object-detection en-keyword=identification of individual crops kn-keyword=identification of individual crops en-keyword=drones kn-keyword=drones END start-ver=1.4 cd-journal=joma no-vol=18 cd-vols= no-issue= article-no= start-page=102828 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202511 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Development of FTase inhibitors inspired by the structures of andrastins en-subtitle= kn-subtitle= en-abstract= kn-abstract=We designed and synthesized structurally simple farnesyl transferase (FTase) inhibitors (1a?1d) by leveraging andrastin, a natural product with FTase inhibitory activity. 1a?1d possess a cyclopentane-1,3-dione core, which is critical for FTase recognition; a farnesyl moiety, which is a simplified motif of A to C rings of andrastin; and a carboxylic acid or methoxycarbonyl group, which enables multipoint hydrogen bonding interactions with FTase. Competitive inhibition experiments revealed that 1d has the most potent FTase inhibitory activity. Docking simulation analysis of 1a?1d with FTase suggested that the multipoint hydrogen bonding interactions between the cyclopentane-1,3-dione moiety and the carboxyl group play an important role in FTase recognition. en-copyright= kn-copyright= en-aut-name=KitamuraFumino en-aut-sei=Kitamura en-aut-mei=Fumino kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TaniokaMasaru en-aut-sei=Tanioka en-aut-mei=Masaru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KosakaAyano en-aut-sei=Kosaka en-aut-mei=Ayano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsuzawaNao en-aut-sei=Matsuzawa en-aut-mei=Nao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ObitaTakayuki en-aut-sei=Obita en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SakajiriYuko en-aut-sei=Sakajiri en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShibataTomokazu en-aut-sei=Shibata en-aut-mei=Tomokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SawadaRyusuke en-aut-sei=Sawada en-aut-mei=Ryusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YokoyamaTakeshi en-aut-sei=Yokoyama en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KohyamaAki en-aut-sei=Kohyama en-aut-mei=Aki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YamadaTsuyoshi en-aut-sei=Yamada en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YamanishiYoshihiro en-aut-sei=Yamanishi en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MizuguchiMineyuki en-aut-sei=Mizuguchi en-aut-mei=Mineyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MatsuyaYuji en-aut-sei=Matsuya en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=2 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=3 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=4 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=5 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=6 en-affil= kn-affil= affil-num=7 en-affil=Department of Complex Systems Science, Graduate School of Informatics, Nagoya University kn-affil= affil-num=8 en-affil=Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=10 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=11 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=12 en-affil=Department of Complex Systems Science, Graduate School of Informatics, Nagoya University kn-affil= affil-num=13 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=14 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= en-keyword=Andrastin analogs kn-keyword=Andrastin analogs en-keyword=Farnesyl transferase (FTase) inhibitor kn-keyword=Farnesyl transferase (FTase) inhibitor en-keyword=Hydrogen bonding interactions kn-keyword=Hydrogen bonding interactions en-keyword=Cyclopentane-1,3-dione kn-keyword=Cyclopentane-1,3-dione en-keyword=Molecular docking kn-keyword=Molecular docking END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page=33 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Large-scale rainfall characteristics at the heavy rainfall event around the western Japan during 5?7 July 2018 kn-title=2018”N7ŒŽ5“ú?7“ú‚̼“ú–{‹‰J‚É‚¨‚¯‚éLˆæ~…“Á« en-subtitle= kn-subtitle= en-abstract= kn-abstract=@Large-scale rainfall characteristics at the heavy rainfall event around the western Japan for 5?7 July 2018 were analyzed with use of the 10-mimute precipitation data at the surface meteorological observation stations of the Japan Meteorological Agency, and so on. In this case, the area with 3 days total precipitation of near or more than 300 mm was distributed widely from northern Kyushu to Shiga and Fukui Prefectures. As in the many heavy rainfall events around Kyushu District in the mature stage of the Baiu season, contribution of the intense rainfall with more than 4 mm/10-minute (24 mm/h) attained about one third of the areal mean total precipitation. However, it is noted that the "not so intense rain" with less than 2 mm/10-minute (12 mm/h) also contributed to about one third of the huge total precipitation in the wide area. In short, this case could be characterized by the mixture of the western Japan type heavy rainfall event and the eastern Japan type one. en-copyright= kn-copyright= en-aut-name=KATOKuranoshin en-aut-sei=KATO en-aut-mei=Kuranoshin kn-aut-name=‰Á“¡“àåUi kn-aut-sei=‰Á“¡ kn-aut-mei=“àåUi aut-affil-num=1 ORCID= en-aut-name=MATSUMOTOKengo en-aut-sei=MATSUMOTO en-aut-mei=Kengo kn-aut-name=¼–{Œ’Œá kn-aut-sei=¼–{ kn-aut-mei=Œ’Œá aut-affil-num=2 ORCID= en-aut-name=OTANIKazuo en-aut-sei=OTANI en-aut-mei=Kazuo kn-aut-name=‘å’J˜a’j kn-aut-sei=‘å’J kn-aut-mei=˜a’j aut-affil-num=3 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæi—‰Èj affil-num=2 en-affil=Okayama Gakugeikan High School kn-affil=‰ªŽRŠwŒ|ŠÙ‚“™ŠwZ affil-num=3 en-affil=TV Setouchi Broadcasting Co., LTD. kn-affil=ƒeƒŒƒr‚¹‚Æ‚¤‚¿(Š”) en-keyword=western Japan heavy rainfall in July 2018 kn-keyword=western Japan heavy rainfall in July 2018 en-keyword=10-minute precipitation data kn-keyword=10-minute precipitation data en-keyword=east-west difference of the Baiu precipitation kn-keyword=east-west difference of the Baiu precipitation END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page=21 end-page=31 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A trial of lesson practice at the university on the variety of heavy rainfall characteristics based on the 10-minute precipitation data toward promoting the meteorological disaster prevention literacy kn-title=10•ªŠÔ~…—Ê‚©‚ç‘å‰J‚Ì“Á’¥‚Ì‘½—l«‚𑨂¦‚é‘åŠw‚Å‚ÌŽö‹Æ‚ÌŽŽ‚Ýi–hЋCÛƒŠƒeƒ‰ƒV[ˆç¬‚ÖŒü‚¯‚Äj en-subtitle= kn-subtitle= en-abstract= kn-abstract=@In the disaster prevention education on the heavy rainfall around Japan, it is also important to promote the meteorological literacy on the seasonal and regional differences of their rainfall characteristics such as the convective rain or stratiform rain, together with their total amount of precipitation and their occurrence frequency. As the first step toward the above purpose, the present study made a lesson practice for the university students by utilizing the 10-minute precipitation data for the four heavy rainfall events, in which the types of the heavy rainfall (although all the cases examined in the lesson are relating to the deep convective clouds) are rather different from each other, such as the differences of the rainfall intensity at the peak time, short-period variation of the rainfall intensity and the persistency of the rainfall including the "not so intense rainfall". The reports by the students seem to perceive the different features among these events briefly, but the students' attention to how long the intense rainfall with short-period variation or "not so intense rainfall" lasted was not so sufficient. en-copyright= kn-copyright= en-aut-name=KATOKuranoshin en-aut-sei=KATO en-aut-mei=Kuranoshin kn-aut-name=‰Á“¡“àåUi kn-aut-sei=‰Á“¡ kn-aut-mei=“àåUi aut-affil-num=1 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæi—‰Èj en-keyword=disaster prevention education kn-keyword=disaster prevention education en-keyword=variety of the heavy rainfall characteristics kn-keyword=variety of the heavy rainfall characteristics en-keyword=meteorological disaster prevention literacy kn-keyword=meteorological disaster prevention literacy en-keyword=use of the 10-minute precipitation data kn-keyword=use of the 10-minute precipitation data END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page=9 end-page=19 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Petrological study of Sue ware from the Sabukaze kiln site, Okayama Prefecture kn-title=Š¦•—ŒÃ—qÕŒQ{ŒbŠí‚ÌŠâΊw“IŒ¤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract=@The Sabukaze kiln site, a representative ancient tunnel-kiln site in the Kibi region, worked during the Asuka period (from early 7th century to early 8th century) to produce Sue ware including jars, cups, coffins, and ornamental tiles. To determine the provenance of the materials used for the Sue ware, we carried out petrological analyses of 13 Sue sherds, including optical microscopy, X-ray diffractometry, X-ray fluorescence spectroscopy, Raman spectroscopy, and electron-probe analysis. In spite of the difference of production time, all the Sue sherds show close similarities in modal proportion of mineral inclusions with dominant quartz and feldspar, and minor volcanic glass, in chemical compositions of feldspar and interstitial matrix, and in whole-sherd chemical composition. These similarities suggest that the paste materials of the Sabukaze Sue ware were commonly derived from weathered rhyolitic rocks and obtained from the same or neighboring mining site(s) located near the kiln site. en-copyright= kn-copyright= en-aut-name=ANAMITaiji en-aut-sei=ANAMI en-aut-mei=Taiji kn-aut-name=ˆ¢“쑾Žm kn-aut-sei=ˆ¢“ì kn-aut-mei=‘¾Žm aut-affil-num=1 ORCID= en-aut-name=NOZAKAToshio en-aut-sei=NOZAKA en-aut-mei=Toshio kn-aut-name=–ìâr•v kn-aut-sei=–ìâ kn-aut-mei=r•v aut-affil-num=2 ORCID= en-aut-name=KIMURAOsamu en-aut-sei=KIMURA en-aut-mei=Osamu kn-aut-name=–Ø‘º— kn-aut-sei=–Ø‘º kn-aut-mei=— aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Earth Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŠÂ‹«¶–½Ž©‘R‰ÈŠwŒ¤‹†‰È affil-num=2 en-affil=Department of Earth Sciences, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŠÂ‹«¶–½Ž©‘R‰ÈŠwŠwˆæ affil-num=3 en-affil=Department of Archaeology, Osaka University kn-affil=‘åã‘åŠwlŒÃŠwŒ¤‹†Žº en-keyword=Sabukaze kiln site kn-keyword=Sabukaze kiln site en-keyword=Sue ware kn-keyword=Sue ware en-keyword=provenance kn-keyword=provenance en-keyword=petrology kn-keyword=petrology END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Microtremor exploration in Kojima Bay area, Okayama Plain kn-title=‰ªŽR•½–쎙“‡˜pŠÝ•”‚Å‚Ì”÷“®ƒAƒŒƒC’T¸ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@This report describes microtremor array observations conducted at two sites for deep exploration and three sites for shallow exploration around Kojima Bay area in the southern Okayama Plain. Based on these records, the ground velocity structures were estimated. The results yielded solutions indicating the depth of the top of the seismic base layer (equivalent to 3 km/s layer) ranges from 140 to 300 m, while the depth of the top of the engineering basement layer (equivalent to 0.6 km/s layer) is approximately about 13?14 m. The shallow exploration results also suggested the possible presence of an inversion layer. These estimated velocity structure models provided a reasonable explanation for the observed phase velocities. en-copyright= kn-copyright= en-aut-name=YAMADANobuyuki en-aut-sei=YAMADA en-aut-mei=Nobuyuki kn-aut-name=ŽR“cL”V kn-aut-sei=ŽR“c kn-aut-mei=L”V aut-affil-num=1 ORCID= en-aut-name=TAKENAKAHiroshi en-aut-sei=TAKENAKA en-aut-mei=Hiroshi kn-aut-name=’|’†”ŽŽm kn-aut-sei=’|’† kn-aut-mei=”ŽŽm aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Science and Technology, Kochi University kn-affil=‚’m‘åŠw—HŠw•”’n‹…ŠÂ‹«–hЊw‰È affil-num=2 en-affil=Department of Earth Sciences, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŠÂ‹«¶–½Ž©‘R‰ÈŠwŠwˆæ en-keyword=Okayama Plain kn-keyword=Okayama Plain en-keyword=Kojima Bay kn-keyword=Kojima Bay en-keyword=Microtremor array exploration kn-keyword=Microtremor array exploration en-keyword=S-wave velocity structure model kn-keyword=S-wave velocity structure model END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=155 end-page=174 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Does Environmental Spending Reduce Firm Risk? Evidence from Japanese Companies kn-title=ŠÂ‹«Žxo‚ÍŠé‹ÆƒŠƒXƒN‚ðŒyŒ¸‚·‚é‚Ì‚©H“ú–{Šé‹Æ‚ÌŽÀØ•ªÍ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@This study examines how environmental conservation costs (ECC) affects firm risk, using changes in leverage ratios and earnings volatility as stand-ins for risk. This study evaluates the direct impact of ECC and its relationship to profitability (ROA) using panel data of Japanese companies from 2010 to 2022 and Pooled OLS regression models. The results demonstrate the risk-mitigating function of sustainability investments by showing that, although independent ECC have little direct significance, their interaction with firm profitability dramatically lowers earnings volatility and leverage instability. These findings underscore the economic value of environmental strategies, suggesting that incorporating profitability considerations into sustainability practices enhances operational stability and reduces risk exposure. To help policymakers, investors, and corporate managers strike a balance between sustainability and financial performance, this study contributes to the growing body of research on the relationship between the environment and finance. en-copyright= kn-copyright= en-aut-name=NAZIRYUSRA en-aut-sei=NAZIR en-aut-mei=YUSRA kn-aut-name=ƒiƒW[ƒ‹ƒ†ƒXƒ‰ kn-aut-sei=ƒiƒW[ƒ‹ kn-aut-mei=ƒ†ƒXƒ‰ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È en-keyword=Environmental Accounting kn-keyword=Environmental Accounting en-keyword=Environmental Conservation Costs kn-keyword=Environmental Conservation Costs en-keyword=Firm Risk kn-keyword=Firm Risk en-keyword=Earnings Volatility kn-keyword=Earnings Volatility en-keyword=ESG kn-keyword=ESG en-keyword=and Risk Management Leverage Ratio kn-keyword=and Risk Management Leverage Ratio en-keyword=Sustainability kn-keyword=Sustainability en-keyword=Panel Data kn-keyword=Panel Data en-keyword=Japanese Companies kn-keyword=Japanese Companies END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=101 end-page=120 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Relationships between Gender Role, Ambivalent Sexism and Vocational Motivation kn-title=«–ðŠ„‚Æ—¼–ʉ¿’l“I«·•ÊŽå‹`‚É‚¨‚¯‚éA‹Æ“®‹@‚Æ‚ÌŠÖ˜A en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HAPPOSuzuha en-aut-sei=HAPPO en-aut-mei=Suzuha kn-aut-name=”ª•û—Á—t kn-aut-sei=”ª•û kn-aut-mei=—Á—t aut-affil-num=1 ORCID= en-aut-name=SUMIOKAKyoko en-aut-sei=SUMIOKA en-aut-mei=Kyoko kn-aut-name=Z‰ª‹±Žq kn-aut-sei=Z‰ª kn-aut-mei=‹±Žq aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=85 end-page=99 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Economic Value Generated by Innovations in Photographic Technology kn-title=ŽÊ^‹Zp‚̃Cƒmƒx[ƒVƒ‡ƒ“‚ª‘no‚·‚éŒoω¿’l en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MIYAZAKISatoru en-aut-sei=MIYAZAKI en-aut-mei=Satoru kn-aut-name=‹{èŒå kn-aut-sei=‹{è kn-aut-mei=Œå aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=47 end-page=63 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Psychological changes in Japanese students who experienced interruption of their study abroad due to the COVID-19 pandemic: Analysis of the process of reinterpretation using TEM diagrams kn-title=ƒRƒƒi‰Ð‚ÅŒ»’n—¯Šw’†’f‘ÌŒ±‚ð‚µ‚½“ú–{lŠw¶‚É‚¨‚¯‚éS—“I•Ï—e \ TEM }‚ð—p‚¢‚½‘ÌŒ±‚̂Ƃ炦’¼‚µ‰ß’ö‚Ì•ªÍ \ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SAKOKoyuri en-aut-sei=SAKO en-aut-mei=Koyuri kn-aut-name=”—‚±‚ä‚è kn-aut-sei=”— kn-aut-mei=‚±‚ä‚è aut-affil-num=1 ORCID= en-aut-name=TANAKATomoko en-aut-sei=TANAKA en-aut-mei=Tomoko kn-aut-name=“c’†‹¤Žq kn-aut-sei=“c’† kn-aut-mei=‹¤Žq aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=31 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Current Status and Challenges in Reproductive Health and Rights in South Australia:Insights from Adelaide kn-title=“ìƒI[ƒXƒgƒ‰ƒŠƒABiƒAƒfƒŒ[ƒhj‚̃Šƒvƒƒ_ƒNƒeƒBƒuEƒwƒ‹ƒX•ƒ‰ƒCƒc‚ð‚ß‚®‚錻ó‚Ɖۑè en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SAITOKeisuke en-aut-sei=SAITO en-aut-mei=Keisuke kn-aut-name=âV“¡Œ\‰î kn-aut-sei=âV“¡ kn-aut-mei=Œ\‰î aut-affil-num=1 ORCID= en-aut-name=SUGANOSetsuko en-aut-sei=SUGANO en-aut-mei=Setsuko kn-aut-name=›–ìÛŽq kn-aut-sei=›–ì kn-aut-mei=ÛŽq aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È affil-num=2 en-affil= kn-affil=“Œ‹ž‰ÈŠw‘åŠwŽÐ‰ï˜AŒgEDE&I–{•” END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=1 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Student Perceptions of Group Work in Multicultural Collaborative Learning : A Case Study in an Area Studies Class Using GIS Software kn-title=‘½•¶‰»‹¤C‚Ì‚½‚߂̃Oƒ‹[ƒvƒ[ƒN‚©‚çŠw¶‚͉½‚ðŠ´‚¶‚½‚Ì‚©H \ GIS ƒ\ƒtƒg‚ðŽg—p‚µ‚½’nˆæŒ¤‹†Žö‹Æ‚©‚ç‚̈êlŽ@ \ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=INAMORITakao en-aut-sei=INAMORI en-aut-mei=Takao kn-aut-name=ˆîXŠx‰› kn-aut-sei=ˆîX kn-aut-mei=Šx‰› aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹¤’Ê‹³ˆçEƒOƒ[ƒoƒ‹—̈æ END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž† en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽRŽsŒüêE•Z‹u—˂̈âÕ‘ª—Ê’²¸ŠT—v•ñ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Œõ–{‡ kn-aut-sei=Œõ–{ kn-aut-mei=‡ aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=쌎 kn-aut-sei=쌎 kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=â–ì•É“l kn-aut-sei=â–ì kn-aut-mei=•É“l aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3 article-no= start-page=41 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Re-theorizing Consumer Behavior in the Age of Human?AI Coexistence: The AIBCBM Framework kn-title=AI ‹¤¶Žž‘ã‚É‚¨‚¯‚éÁ”ïŽÒs“®‚ÌÄ—˜_‰»\AIBCBM ƒtƒŒ[ƒ€ƒ[ƒN\ en-subtitle= kn-subtitle= en-abstract=@This study aims to construct and present the AI-Based Consumer Behavior ModeliAIBCBMj as a theoretical framework that systematically explains the tripartite interaction among companies, consumers, and AI in environments where AI intervenes from the pre-decision stage. First, it identifies the critical theoretical limitations of existing consumer behavior models, which fail to adequately address contemporary phenomena such as algorithmic exposure, recursive learning loops, and AI-mediated social influence. Building upon this, the study presents the AIBCBM iAI-Based Consumer Behavior Modelj, which conceptualizes consumer behavior in the era of AI symbiosis as a tripartite cyclical structure involvingg business?AI?consumer.h
@In constructing the model, rather than oversimplifying complex reality, theoretical clarity and analytical tractability are ensured by separating it into a tripartite co-evolutionary structure model iFigure 2j, a behavioral process model illustrating the dynamics of behavior generationiTable 3j, a conceptual structure modeliFigure 3j, and a behavioral typology modeliFigure 4j. The theoretical contributions of this study are summarized in five points:
i1j redefining System 1 as a behavioral generation mechanism;
i2j redefining decision-making agents and power structures;
i3j theoretically modeling nonlinear, high-speed feedback loops in consumer behavior;
i4j Theoretical redefinition of non-consumption and JOMO as strategic behaviors grounded in well-being and human agency.
i5j reconceptualizing consumer behavior from a "decision-making model" to a "behavior generation model."
@Moreover, the duality highlighted in this study?where algorithm-driven utility enhancement and autonomy impairment can coexist?provides a new normative and theoretical evaluation framework for marketing strategies and policy design in the AI era. AIBCBM functions as a theoretical platform that integrates these perspectives, serving as a foundation for future theoretical development and empirical validation. In particular, AIBCBM is distinctive in positioning JOMO and non-consumption not as passive withdrawal from algorithmic environments, but as strategic behaviors through which consumers intentionally calibrate their distance from AI-constructed choice architectures to preserve human agency, well-being, and human-likeness.
@Finally, the proposed model serves as a theoretical coordinate framework that systematically connects firm-side AI design, algorithmic dynamics, and consumer agency and well-being, thereby bridging empirical inquiry and normative design in the age of AI co-existence. kn-abstract=@–{Œ¤‹†‚ÍCAI‚ªˆÓŽvŒˆ’è‚Ì‘O’iŠK‚©‚ç‰î“ü‚·‚éŠÂ‹«‚É‚¨‚¢‚ÄCŠé‹ÆEÁ”ïŽÒEAI‚ÌŽOŽÒ‘ŠŒÝì—p‚ð‘ÌŒn“I‚Éà–¾‚·‚é—˜_˜g‘g‚Ý‚Æ‚µ‚ÄCArtificial Intelligence-Based Consumer Behavior ModeliAIBCBMj‚ð\’z‚µC’ñŽ¦‚·‚邱‚Æ‚ð–Ú“I‚Æ‚·‚éB‚Ü‚¸CŠù‘¶‚ÌÁ”ïŽÒs“®ƒ‚ƒfƒ‹‚ªCƒAƒ‹ƒSƒŠƒYƒ€˜IoCÄ‹A“IŠwKƒ‹[ƒvCAI”}‰îŒ^ŽÐ‰ï“I‰e‹¿iAlgorithmic Social Influencej‚Æ‚¢‚Á‚½Œ»‘ã“IŒ»Û‚ð\•ª‚Ɉµ‚¦‚È‚¢‚Æ‚¢‚¤Œˆ’è“I‚È—˜_“IŒÀŠE‚𖾂炩‚É‚·‚éB‚»‚Ì‚¤‚¦‚ÅCAI‹¤¶Žž‘ã‚É‚¨‚¯‚éÁ”ïŽÒs“®‚ðCuŠé‹Æ|AI|Á”ïŽÒv‚ÌŽOŽÒzŠÂ\‘¢‚Æ‚µ‚Ä‘¨‚¦‚éAIBCBM‚ð’ñŽ¦‚·‚éB
@ƒ‚ƒfƒ‹\’z‚ÉÛ‚µ‚Ä‚ÍC•¡ŽG‚ÈŒ»ŽÀ‚ð‰ß“x‚É’Pƒ‰»‚·‚é‚Ì‚Å‚Í‚È‚­CŽOŽÒ‹¤i‰»\‘¢ƒ‚ƒfƒ‹i}‚QjCs“®¶¬‚Ì“®‘Ô‚ðŽ¦‚·s“®ƒvƒƒZƒXƒ‚ƒfƒ‹i•\‚RjCŠT”O\‘¢ƒ‚ƒfƒ‹i}‚RjCs“®—ÞŒ^ƒ‚ƒfƒ‹i}‚Sj‚É•ª—£‚·‚邱‚Æ‚ÅC—˜_“I–¾—Ä«‚Æ•ªÍ‰Â”\«‚ðŠm•Û‚µ‚½B–{Œ¤‹†‚Ì—˜_“IvŒ£‚ÍC‡@System ‚P‚ðs“®¶¬ƒƒJƒjƒYƒ€‚Æ‚µ‚ÄÄ’è‹`‚µ‚½“_C‡AˆÓŽvŒˆ’èŽå‘Ì‚ÆŒ —Í\‘¢‚ðÄ’è‹`‚µ‚½“_C‡BÁ”ïŽÒs“®‚É‚¨‚¯‚é”ñüŒ`E‚‘¬ƒtƒB[ƒhƒoƒbƒNƒ‹[ƒv‚ð—˜_‰»‚µ‚½“_C‡C”ñÁ”ï‚âJOMO‚ðCK•Ÿ‚ÆŽå‘Ì«‚ɪ‚´‚µ‚½í—ª“Is“®‚Æ‚µ‚Ä—˜_“I‚ÉÄ’è‹`‚µ‚½“_C‡DÁ”ïŽÒs“®‚ðuˆÓŽvŒˆ’胂ƒfƒ‹v‚©‚çus“®¶¬ƒ‚ƒfƒ‹v‚Ö—˜_“I‚É“]Š·‚µ‚½“_‚ÉW–ñ‚³‚ê‚éB‚³‚ç‚ÉC–{Œ¤‹†‚ª’ñŽ¦‚·‚éCƒAƒ‹ƒSƒŠƒYƒ€‚É‚æ‚éŒø—p‚ÌŒüã‚ÆŽ©—¥«‚̚ʑ¹‚ª•¹‘¶‚µ‚¤‚é‚Æ‚¢‚¤“ñ–Ê«‚ÍCAIŽž‘ã‚É‚¨‚¯‚éƒ}[ƒPƒeƒBƒ“ƒOí—ª‚¨‚æ‚Ñ­ôÝŒv‚ɑ΂µ‚ÄC‹K”Í“I‚©‚—˜_“I‚ÈV‚½‚È•]‰¿Ž²‚ð’ñ‹Ÿ‚·‚éBAIBCBM‚ÍC‚±‚ê‚ç‚ÌŽ‹À‚𓇂·‚é—˜_“Iƒvƒ‰ƒbƒgƒtƒH[ƒ€‚Æ‚µ‚ÄC¡Œã‚ÌŽÀØŒ¤‹†‚ÉŒü‚¯‚½Šî”Õ‚Æ‚µ‚Ä‹@”\‚·‚éB‚Æ‚è‚킯C AIBCBM‚ÍCJOMO‚â”ñÁ”ïs“®‚ðCƒAƒ‹ƒSƒŠƒYƒ€ŠÂ‹«‚©‚ç‚ÌŽó“®“I“P‘Þ‚Å‚Í‚È‚­CAI‚É‚æ‚Á‚Ä\’z‚³‚ꂽ‘I‘ðŠÂ‹«‚Æ‚Ì‹——£‚ðˆÓ}“I‚É’²®‚µClŠÔ‚炵‚³ilŠÔ‚Æ‚µ‚Ä‚ÌŽå‘Ì«‚âƒEƒFƒ‹ƒr[ƒCƒ“ƒOj‚ð•ÛŽ‚·‚邽‚ß‚Ìí—ª“Is“®‚Æ‚µ‚Ĉʒu‚¯‚é“_‚É“ÆŽ©«‚ð—L‚·‚éB‚³‚ç‚É–{ƒ‚ƒfƒ‹‚ÍCAIÝŒviŠé‹Æ‘¤jEƒAƒ‹ƒSƒŠƒYƒ€“®‘ÔiAI‘¤jEŽå‘Ì«‚ƃEƒFƒ‹ƒr[ƒCƒ“ƒOiWell-beingjiÁ”ïŽÒ‘¤j‚𓯈ê˜g‘g‚Ý‚ÅÚ‘±‚·‚邱‚Æ‚ÅCAI‹¤¶Žž‘ã‚ÌŽÀØŒ¤‹†‚Æ‹K”ÍÝŒv‚ð‰Ë‹´‚·‚é—˜_“IÀ•WŽ²‚ðŠm—§‚·‚éB en-copyright= kn-copyright= en-aut-name=ShazadigulSawut en-aut-sei=Shazadigul en-aut-mei=Sawut kn-aut-name=‰ÄH’ñŒÃ?¹Œá’ñ kn-aut-sei=‰ÄH’ñŒÃ? kn-aut-mei=¹Œá’ñ aut-affil-num=1 ORCID= affil-num=1 en-affil=Faculty of Humanities and Social Sciences, Okayama University kn-affil= en-keyword=s“®¶¬ƒ‚ƒfƒ‹ (Behavior Generation Model) kn-keyword=s“®¶¬ƒ‚ƒfƒ‹ (Behavior Generation Model) en-keyword=lŠÔ|AI‚Ì‹¤“¯Žå‘Ì« (Human-AI Co-agency/Shared Agency) kn-keyword=lŠÔ|AI‚Ì‹¤“¯Žå‘Ì« (Human-AI Co-agency/Shared Agency) en-keyword=ƒAƒ‹ƒSƒŠƒYƒ€“I‘I‘ðŠÂ‹« (Algorithmic Choice Architecture) kn-keyword=ƒAƒ‹ƒSƒŠƒYƒ€“I‘I‘ðŠÂ‹« (Algorithmic Choice Architecture) en-keyword=”ñÁ”ï^ˆÓ}“I‚È”ñŽg—p (Non-consumption/Intentional Non-use) kn-keyword=”ñÁ”ï^ˆÓ}“I‚È”ñŽg—p (Non-consumption/Intentional Non-use) en-keyword=Ä‹A“IŠwKƒ‹[ƒv (Recursive Learning Loops) kn-keyword=Ä‹A“IŠwKƒ‹[ƒv (Recursive Learning Loops) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3 article-no= start-page=11 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Network Analysis of Interregional Information Exchange: A Study in the Takahashi River Basin Area kn-title=’nˆæŠÔ‚Å‚Ìî•ñŒð—¬‚ÉŠÖ‚·‚éƒlƒbƒgƒ[ƒN•ªÍF‚—Àì—¬ˆæŒ—‚Å‚Ì’²¸‚É‚æ‚é en-subtitle= kn-subtitle= en-abstract=@This paper conducted network analysis focusing on information exchange among participating entities in the "Takahashi River Basin Economic Growth Strategy Council," operating within Okayama Prefecture's "Takahashi River Basin Core City Area." The Takahashi River Basin Collaborative Core City Areai Takahashi River Basin Areajis a collaborative core city area encompassing ten municipalities located around the Takahashi River in Okayama Prefecture: Niimi City, Takahashi City, Soja City, Hayashima Town, Kurashiki City, Yakage Town, Ibara City, Asakuchi City, Satosho Town, and Kasaoka City. For the network analysis within the Takahashi River Basin Area, projects implemented within the area were classified into eight categories. A questionnaire survey was conducted regarding information exchange among participating entities for each project. Network metrics included calculating centrality indicesi degree centrality and betweenness centralityj for each project, along with density, transitivity, and reciprocity. By project type, tourism projects exhibited the densest network structure for information exchange. From a network perspective, tourism projects can be considered the most actively pursued initiative within the Takahashi River Basin area. Furthermore, across all projects, centrality indicators for specific administrative bodies and regional economic organizations, such as chambers of commerce and industry, generally showed high values. This clearly indicates their function as hubs for information exchange and as entities concentrating or dispersing information within the network. Based on the results of network analysis, two recommendations for future regional development in the Takahashi River Basin were proposed from a network perspective. The first is to aim for dense networks across all businesses by sharing the roles of information exchange hubs and information concentration/distribution entities among the entities involved, depending on the business. The second is to aim for a dense network overall by eliminating entities that are not participating at all in the Takahashi River Basin's information exchange network. kn-abstract=@–{e‚Å‚ÍC‰ªŽRŒ§‚Ìu‚—Àì—¬ˆæ˜AŒg’†•“sŽsŒ—v‚Å2014”N‚©‚çŠJ³‚ê‚Ä‚¢‚éu‚—Àì—¬ˆæŒoϬ’·í—ª‰ï‹cv‚É‚¨‚¯‚éŽQ‰ÁŽå‘ÌŠÔ‚Ìî•ñŒð—¬‚ɂ‚¢‚Ẵlƒbƒgƒ[ƒN•ªÍ‚ðs‚Á‚½B‚—Àì—¬ˆæ˜AŒg’†•“sŽsŒ—i‚—Àì—¬ˆæŒ—j‚Æ‚ÍC‰ªŽRŒ§‚—ÀìŽü•Ó‚Ɉʒu‚·‚錻݂ÌVŒ©ŽsC‚—ÀŽsC‘ŽÐŽsC‘“‡’¬C‘q•~ŽsC–îŠ|’¬CˆäŒ´ŽsCóŒûŽsC—¢¯’¬CŠ}‰ªŽs‚Ì10Ž©Ž¡‘Ì‚ªŽQ‰Á‚µ‚Ä‚¢‚é˜AŒg’†•“sŽsŒ—‚Å‚ ‚éB‚—Àì—¬ˆæŒ—‚É‚¨‚¯‚éƒlƒbƒgƒ[ƒN•ªÍ‚ÉÛ‚µ‚Ä‚ÍC“¯Œ—ˆæ“à‚Å“WŠJ‚³‚ê‚Ä‚¢‚鎖‹Æ‚ð‚W‚‚ɕª—Þ‚µC‚»‚ꂼ‚ê‚ÌŽ–‹Æ‚ÉŠÖ‚·‚éŽQ‰ÁŽå‘ÌŠÔ‚Ìî•ñŒð—¬‚ɂ‚¢‚ăAƒ“ƒP[ƒg’²¸‚ðs‚Á‚½Bƒlƒbƒgƒ[ƒNŽw•W‚ɂ‚¢‚Ä‚ÍŽ–‹Æ‚²‚Æ‚ÉŽŸ”’†S«‚Æ”}‰î’†S«‚Ì’†S«Žw•W‚ðC‚Ü‚½Ž–‹Æ•Ê‚É–§“xC„ˆÚ«C‘ŠŒÝ«‚ðŽZo‚µ‚½BŽ–‹Æ•Ê‚É‚Ý‚é‚ÆCŠÏŒõŽ–‹Æ‚ɂ‚¢‚Ä‚Ìî•ñŒð—¬‚ªÅ‚à–§‚ȃlƒbƒgƒ[ƒN\‘¢‚ð‚µ‚Ä‚¨‚èCƒlƒbƒgƒ[ƒN‚ÌŽ‹“_‚Å‚ÍŠÏŒõŽ–‹Æ‚ª‚—Àì—¬ˆæŒ—“à‚Åłਗ͓I‚És‚í‚ê‚Ä‚¢‚鎖‹Æ‚Æ‚¢‚¦‚éB‚Ü‚½‘SŽ–‹Æ‚É‚¨‚¢‚Ä“Á’è‚Ìs­Žå‘Ì‚â¤H‰ï‹cŠ‚ð‚Í‚¶‚ß‚Æ‚·‚é’nˆæŒoÏ’c‘Ì“™‚Ì’†S«Žw•W‚ª‘S‘Ì“I‚É‘å‚«‚È’l‚ð‚Æ‚Á‚Ä‚¨‚èCƒlƒbƒgƒ[ƒN‚É‚¨‚¢‚Äî•ñŒð—¬‚̃nƒu‚âî•ñ‚ÌW’†E•ªŽUŽå‘Ì‚Æ‚µ‚Ä‹@”\‚µ‚Ä‚¢‚邱‚Æ‚ª–¾‚ç‚©‚É‚È‚Á‚½B•ªÍŒ‹‰Ê‚𓥂܂¦Cƒlƒbƒgƒ[ƒN‚ÌŽ‹“_‚©‚ç‚—Àì—¬ˆæŒ—‚Ì¡“x‚Ì’nˆæU‹»‚ɂ‚¢‚Ä‚Q“_’ñŒ¾‚µ‚½B‚P‚‚͎–‹Æ‚É‚æ‚Á‚Äî•ñŒð—¬‚̃nƒu‚âî•ñ‚ÌW’†E•ªŽUŽå‘Ì‚ðŽå‘ÌŠÔ‚Å•ª’S‚·‚邱‚Æ‚É‚æ‚Á‚ÄC‚·‚ׂĂ̎–‹Æ‚Å–§‚ȃlƒbƒgƒ[ƒN‚ð’z‚­‚±‚Æ‚ð–ÚŽw‚·‚±‚Æ‚Å‚ ‚éB‚à‚¤‚P‚‚͂—Àì—¬ˆæŒ—‚Ìî•ñŒð—¬ƒlƒbƒgƒ[ƒN‚É‘S‚­ŽQ‰Á‚µ‚Ä‚¢‚È‚¢Žå‘Ì‚ð‚È‚­‚·‚±‚Æ‚ÅC‘S‘Ì“I‚É–§‚ȃlƒbƒgƒ[ƒN‚ð–ÚŽw‚·‚±‚Æ‚Å‚ ‚éB en-copyright= kn-copyright= en-aut-name=NakamuraRyohei en-aut-sei=Nakamura en-aut-mei=Ryohei kn-aut-name=’†‘º—Ç•½ kn-aut-sei=’†‘º kn-aut-mei=—Ç•½ aut-affil-num=1 ORCID= en-aut-name=YokotaNatsumi en-aut-sei=Yokota en-aut-mei=Natsumi kn-aut-name=‰¡“c‰ÄŽÀ kn-aut-sei=‰¡“c kn-aut-mei=‰ÄŽÀ aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw affil-num=2 en-affil= kn-affil=‰ºŠÖŽs–ðŠ END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3 article-no= start-page=1 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 1998 Amendment to the Foreign Exchange and Foreign Trade Control Act and the Classification of Income from Gains and Losses on Foreign Currency Transactions: How Did the Amendment of 1998 Affect Income Classification? kn-title=1998”N‚ÌŠO‘ˆ×‘Ö‹y‚ÑŠO‘–fˆÕŠÇ—–@‰ü³‚Æ ŠO‘’ʉ݂Ì÷“n‚É‚æ‚鑹‰v‚ÌŠ“¾‹æ•ª \1998”N‚Ì–@‰ü³‚ÍŠ“¾‹æ•ª‚ɂǂ̂悤‚ȉe‹¿‚ð—^‚¦‚½‚Ì‚©\ en-subtitle= kn-subtitle= en-abstract=@The 1998 amendment to the Foreign Exchange and Foreign Trade Control Acti subsequently renamed the Foreign Exchange and Foreign Trade Actj liberalized foreign exchange transactions, which had previously been restricted in principle to authorized foreign exchange banks. This amendment allowed all companies and individuals to freely conduct such transactions.
@This paper first examines the basis for the tax authorities' view that "gains or losses from foreign currency transfers constitute miscellaneous income," drawing from government witness testimony in the Diet and the Tokyo District Court judgement of March 9, 2023. Then it concludes that the 1998 legal amendment, by enabling anyone to freely conduct foreign currency transactions both internationally and domestically, transformed foreign currency into a means of payment functioning as a measure of value. Consequently, it became impossible to conceptualize foreign currency as an asset subject to appreciation or depreciation, leading to the reclassification of income from its transfer from capital gains to miscellaneous income. kn-abstract=@1998”N‚ÌŠO‘ˆ×‘Ö‹y‚ÑŠO‘–fˆÕŠÇ—–@‚̉ü³iˆÈ~CŠO‘ˆ×‘Ö‹y‚ÑŠO‘–fˆÕ–@‚ɉü–¼j‚É‚æ‚èC‚»‚ê‚Ü‚ÅŠO‘ˆ×‘ÖŒö”F‹âs‚ÉŒ´‘¥‚Æ‚µ‚ÄŒÀ‚ç‚ê‚Ä‚¢‚½ŠO‘ˆ×‘ÖŽæˆø‚ªC‚ ‚ç‚ä‚éŠé‹Æ‹y‚ÑŒÂl‚ɉð•ú‚³‚êCŽ©—R‚És‚¤‚±‚Æ‚ª‚Å‚«‚é‚悤‚É‚È‚Á‚½B
@–{e‚ÍC‚Ü‚¸‰ÛÅ“–‹Ç‚ÌuŠO‘’ʉ݂Ì÷“n‚É‚æ‚鑹‰v‚ÍŽGŠ“¾‚ÉŠY“–‚·‚év‚Æ‚ÌŒ©‰ð‚Ì”»’fª‹’‚ðC‘‰ï‚É‚¨‚¯‚é­•{ŽQll“š•Ù‹y‚Ñ“Œ‹ž’nٗߘa‚T”N‚RŒŽ‚X“ú”»Œˆ‚©‚ç“ǂ݉ð‚«C‚»‚Ì‚¤‚¦‚ÅC1998”N‚Ì–@‰ü³‚É‚æ‚èŠO‘’ʉݎæˆø‚ª‘ΊO‹y‚Ñ‘“à‚É‚¨‚¢‚ĉ½l‚àŽ©—R‚És‚¤‚±‚Æ‚ª‚Å‚«‚é‚悤‚É‚È‚Á‚½‚±‚Æ‚©‚çCŠO‘’ʉ݂͎x•¥Žè’i‚Æ‚µ‚ÄŒ¾‚í‚Ή¿’l‚ÌŽÚ“x‚Æ‚µ‚Ä‹@”\‚·‚é‚悤‚É‚È‚èCŽ‘ŽY‚Ì’lオ‚èC’l‰º‚ª‚è‚ðŠÏ”O‚·‚邱‚Æ‚ª‚Å‚«‚È‚­‚È‚Á‚½Œ‹‰Ê‚Æ‚µ‚ÄC‚»‚Ì÷“n‚É‚æ‚銓¾‹æ•ª‚ª÷“nŠ“¾‚©‚çŽGŠ“¾‚ւƕω»‚µ‚½‚Æ‚ÌŒ‹˜_‚𓱂­‚à‚Ì‚Å‚ ‚éB en-copyright= kn-copyright= en-aut-name=NakagawaYoshiyuki en-aut-sei=Nakagawa en-aut-mei=Yoshiyuki kn-aut-name=’†ì‹g”V kn-aut-sei=’†ì kn-aut-mei=‹g”V aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=1 article-no= start-page=146 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=MMP-3 cleavage of Lamin A induces pro-migratory nuclear deformity, nucleophagy, and their autophagic secretion with extracellular vesicles in metastatic cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract=Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targets. MMPs have also been found in extracellular vesicles (EVs), such as exosomes. MMP-3 promotes tumor growth, epithelial-to-mesenchymal transition, genome instability, migration, invasion, and metastasis of cancer cells, and nuclear MMP-3 controls gene transcription. Intranuclear proteolysis by MMPs may significantly alter cancer progression. However, the nuclear substrates of MMP-3 have not been well investigated. In this study, we performed proteomic analyses to identify the nuclear substrates and EV proteins regulated by MMP-3. While rabidly metastatic colon cancer (LuM1) three-dimensionally cultured tumoroids secreted EVs containing 30 protein types, including Lamin A (LMNA), MMP-3, fibronectin (FN1), HSPA8 (Hsc70), ƒÀ-actin (ACTB), and vimentin (VIM), CRISPR/Cas9-based knockout of MMP-3 reduced the secretion of these proteins in EVs. Notably, EV-bound cleaved Lamin secretion was confirmed by immunoelectron microscopy. Also, MMP-3 formed proteolytic dimers via its hemopexin-like repeat domains in nuclei. Many nuclear MMP-3-binding proteins, including Lamin A/C, histones, topoisomerases, and hnRNPs, were screened by co-immunoprecipitation followed by proteomics. Proteolytic MMP-3 overexpression generated a C-terminal 30-kDa fragment of Lamin A, whose cleavage site was defined via structural analysis. MMP-3 digestion of Lamin A induced nuclear deformity (atypia) required for cell migration in confined space. The cleaved Lamin A and MMP-3 were transported with autophagosomes (LC3B+), nucleophagosomes, and amphisomes (CD63?+?LC3B+) and co-secreted with EVs. Proteolytic MMP-3 also induced nuclear speckles of Lamin A, suggesting their roles in transcription and splicing. Clinical analysis revealed that high expressions of MMP3 and LMNA were significantly seen in head and neck squamous cell carcinoma (HNSC) than in the other 16 cancer types, and predicted poor prognosis of patients suffering from HNSC, pancreatic, rectum and lung adenocarcinomas at specific stages. Immunohistochemistry revealed that nuclear MMP-3 and cleaved Lamin were significantly higher expressed in stage IV metastatic HNSC cases than in stage I non-metastatic cases. Taken together, MMP3-cleavage of Lamin A induces nuclear deformity, nucleophagy, and their autophagic co-secretion with EVs in metastatic cancer. Also, high expression of MMP-3 and secretion of Lamin A can predict poor prognosis in multiple cancer types at specific stages. en-copyright= kn-copyright= en-aut-name=EguchiTakanori en-aut-sei=Eguchi en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TahaEman A. en-aut-sei=Taha en-aut-mei=Eman A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakanoKeisuke en-aut-sei=Nakano en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TiwariVikas en-aut-sei=Tiwari en-aut-mei=Vikas kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakebeKatsuki en-aut-sei=Takebe en-aut-mei=Katsuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=InoueTomohiro en-aut-sei=Inoue en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=XingLizi en-aut-sei=Xing en-aut-mei=Lizi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SogawaChiharu en-aut-sei=Sogawa en-aut-mei=Chiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OkamotoKuniaki en-aut-sei=Okamoto en-aut-mei=Kuniaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=CalderwoodStuart K. en-aut-sei=Calderwood en-aut-mei=Stuart K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Biochemistry, Faculty of Science, Ain Shams University kn-affil= affil-num=3 en-affil=Department of Oral Pathology and Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Council of Scientific & Industrial Research-Indian Institute of Toxicological Research kn-affil= affil-num=5 en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Food and Health Sciences, Faculty of Environmental Studies, Hiroshima Institute of Technology kn-affil= affil-num=9 en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Division of Molecular and Cellular Biology, Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School kn-affil= en-keyword=Lamin A (LMNA) kn-keyword=Lamin A (LMNA) en-keyword=Matrix metalloprotease (MMP) kn-keyword=Matrix metalloprotease (MMP) en-keyword=Proteolysis kn-keyword=Proteolysis en-keyword=Extracellular vesicle (EV) kn-keyword=Extracellular vesicle (EV) en-keyword=Exosome kn-keyword=Exosome en-keyword=Autophagy kn-keyword=Autophagy en-keyword=Amphisome kn-keyword=Amphisome en-keyword=Proteome kn-keyword=Proteome en-keyword=Nuclear deformity kn-keyword=Nuclear deformity en-keyword=Migration kn-keyword=Migration en-keyword=Metastatic cancer kn-keyword=Metastatic cancer en-keyword=Head and neck squamous cell carcinoma kn-keyword=Head and neck squamous cell carcinoma en-keyword=Colorectal cancer kn-keyword=Colorectal cancer END start-ver=1.4 cd-journal=joma no-vol=165 cd-vols= no-issue= article-no= start-page=105344 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202503 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Local immune response induced by intra-fin antigen injection in Japanese medaka (Oryzias latipes) is a useful model for immunological studies en-subtitle= kn-subtitle= en-abstract= kn-abstract=Teleost fishes play a pivotal role in advancing our understanding of immune system evolution because they retain the ancient characteristics of vertebrate immunity, encompassing both innate and adaptive immune systems. Among these, innate immunity plays a critical role in fish as the first line of defense, coordinating rapid responses to pathogen infections. However, the lack of fish-specific immunological methodologies has limited progress in elucidating fish immune mechanisms. To better understand how the innate immune response develops and resolves in fish, detailed observation and integrative analysis of leukocytes at multiple time points is necessary. In the present study, an intra-fin injection method for observing local immune responses in Japanese medaka (Oryzias latipes) was tested and optimized to analyze the progression of zymosan-induced innate immune responses. Zymosan-injected medaka showed a rapid immune response characterized by leukocyte recruitment and phagocytosis. Using TG(FmpxP:mCherry) transgenic medaka with mCherry fluorescence driven by myeloperoxidase (mpx) promoter, granulocyte chemotaxis towards the site of zymosan entry was successfully visualized. The rapid increase in tumor necrosis factor ƒ¿ (tnfa), interleukin-1ƒÀ (il1b), interleukin-6 (il6), and CXC motif chemokine ligand 8 (cxcl8) expressions in zymosan-injected anal fins provided a molecular basis for the visualized tissue-specific cellular response. Our study underscores the dynamic orchestration of immune components during the innate immune response in Japanese medaka and highlights their potential as a promising model for immunological research. en-copyright= kn-copyright= en-aut-name=RyuTsukasa en-aut-sei=Ryu en-aut-mei=Tsukasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshinoMizuki en-aut-sei=Yoshino en-aut-mei=Mizuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TseWilliam Ka Fai en-aut-sei=Tse en-aut-mei=William Ka Fai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AnsaiSatoshi en-aut-sei=Ansai en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IguchiTaisen en-aut-sei=Iguchi en-aut-mei=Taisen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KumarAnu en-aut-sei=Kumar en-aut-mei=Anu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SomamotoTomonori en-aut-sei=Somamoto en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakaoMiki en-aut-sei=Nakao en-aut-mei=Miki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OginoYukiko en-aut-sei=Ogino en-aut-mei=Yukiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Graduate School of Bioresource and Bioenvironmental Sciences, Laboratory of Marine Biochemistry, Kyushu University kn-affil= affil-num=2 en-affil=Graduate School of Bioresource and Bioenvironmental Sciences, Laboratory of Marine Biology, Kyushu University kn-affil= affil-num=3 en-affil=Graduate School of Bioresource and Bioenvironmental Sciences, Laboratory of Developmental Disorders and Toxicology, Kyushu University kn-affil= affil-num=4 en-affil=Ushimado Marine Institute, Faculty of Science, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Nanobioscience, Yokohama City University kn-affil= affil-num=6 en-affil=Commonwealth Scientific and Industrial Research Organisation, CSIRO Environment kn-affil= affil-num=7 en-affil=Graduate School of Bioresource and Bioenvironmental Sciences, Laboratory of Marine Biochemistry, Kyushu University kn-affil= affil-num=8 en-affil=Graduate School of Bioresource and Bioenvironmental Sciences, Laboratory of Marine Biochemistry, Kyushu University kn-affil= affil-num=9 en-affil=Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University kn-affil= en-keyword=Chemotaxis kn-keyword=Chemotaxis en-keyword=Local immunity kn-keyword=Local immunity en-keyword=Inflammation kn-keyword=Inflammation en-keyword=Innate immunity kn-keyword=Innate immunity en-keyword=Phagocytosis kn-keyword=Phagocytosis en-keyword=Zymosan kn-keyword=Zymosan END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue= article-no= start-page=63 end-page=77 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Academic Contribution of the Teaching Staff of the Faculty of Letters, Okayama Universityi2024j kn-title=•¶Šw•”‹³ˆõŒ¤‹†Šˆ“®ˆê——i2024”N“xj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue= article-no= start-page=39 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Inheritance and Changes of Accents in the Hiroshima City Dialecti1j: Generational Variation in One-, Two-, and Three-Mora Nouns kn-title=L“‡Žs•ûŒ¾‚É‚¨‚¯‚éƒAƒNƒZƒ“ƒg‚ÌŒp³‚Æ•Ï—ei1j„Ÿ 1 ”E2 ”E3 ”–¼ŽŒ‚̃AƒNƒZƒ“ƒg‚Ì¢‘ã“I“®‘Ô „Ÿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NAKATOYasue en-aut-sei=NAKATO en-aut-mei=Yasue kn-aut-name=’†“Œ–õŒb kn-aut-sei=’†“Œ kn-aut-mei=–õŒb aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END 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en-keyword=NITS kn-keyword=NITS en-keyword=ê–åE‚Æ‚µ‚Ä‚Ì‹³Eˆõ kn-keyword=ê–åE‚Æ‚µ‚Ä‚Ì‹³Eˆõ END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=5 article-no= start-page=25-00095 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Examining OpenFOAM-based LES analysis in terms of inviscid energy conservation and viscous turbulence decay en-subtitle= kn-subtitle= en-abstract= kn-abstract=The present study examines an OpenFOAM-based LES analysis from the viewpoints of inviscid energy conservation and viscous turbulence decay. The Smagorinsky model is employed as the sub-grid scale (SGS) model, and a two-dimensional periodic analytical solution and a three-dimensional periodic Taylor-Green vortex (TGV) are employed to represent inviscid flows. The analytical relationship for the kinetic energy K, dK/dt = 0, with t as the dimensionless time, is utilized to validate the OpenFOAM results. For the viscous flow case, the TGV flow in a three-dimensional periodic cubic domain is adopted, and its turbulence kinetic energy distribution is compared with that obtained by a spectral method to examine the analysis. The OpenFOAM-based analysis exhibits energy conservation error in flows that should ideally conserve energy. For the two-dimensional flow, this error decreases with increasing grid resolution N. However, in the three-dimensional flow, the error does not improve even with higher N. In the three-dimensional TGV flow, the turbulence kinetic energy predicted by OpenFOAM exhibits a strong agreement with that from the spectral method when a standard constant value of the Smagorinsky model is employed and the mesh is sufficiently refined. Conversely, for a condition of relatively coarse mesh, the decay characteristics of turbulent kinetic energy deviate from those of the spectral method, and a higher constant value of the Smagorinsky model than the default value becomes necessary to reproduce comparable results. These results suggests that even in LES simulations where highly accurate conservation laws are not satisfied, adjusting the model constants so that the predicted values match experimental or numerical reference data can improve the apparent reliability of the turbulent kinetic energy in the decaying turbulence. en-copyright= kn-copyright= en-aut-name=SUZUKIHiroki en-aut-sei=SUZUKI en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TANAKAKento en-aut-sei=TANAKA en-aut-mei=Kento kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KOUCHIToshinori en-aut-sei=KOUCHI en-aut-mei=Toshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Turbulent flows kn-keyword=Turbulent flows en-keyword=Numerical simulation kn-keyword=Numerical simulation en-keyword=Large-eddy simulation kn-keyword=Large-eddy simulation en-keyword=Energy conservation kn-keyword=Energy conservation en-keyword=Decaying turbulence kn-keyword=Decaying turbulence END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260219 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Tabtoxin biosynthetic gene cluster in Pseudomonas syringae pv. tabaci 6605 genomic island 1 (GI-1Pta6605) is required for severe disease symptoms en-subtitle= kn-subtitle= en-abstract= kn-abstract=One of the genomic islands in Pseudomonas syringae pv. tabaci 6605 (GI-1Pta6605) has been identified as a pathogenicity island required for virulence because the deletion almost completely eliminated disease symptoms in inoculation tests at 4?~?105 CFU/ml. GI-1Pta6605 contains four cargo regions (CRs) named CR-1 to CR-4. The ?CR-4 mutant did not produce tabtoxin like ?GI-1 and disease symptoms did not develop in tobacco. However, it grew, although to a lesser extent than the wild-type strain. These results indicate that the tabtoxin biosynthetic gene cluster in GI-1 is required for virulence but not for establishment of compatibility. en-copyright= kn-copyright= en-aut-name=KunishiKotomi en-aut-sei=Kunishi en-aut-mei=Kotomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujisawaNorika en-aut-sei=Fujisawa en-aut-mei=Norika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsuiHidenori en-aut-sei=Matsui en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakataNanami en-aut-sei=Sakata en-aut-mei=Nanami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NoutoshiYoshiteru en-aut-sei=Noutoshi en-aut-mei=Yoshiteru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ToyodaKazuhiro en-aut-sei=Toyoda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=The Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=The Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=The Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=The Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=The Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=The Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=7 en-affil=The Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=GI-1Pta6605 kn-keyword=GI-1Pta6605 en-keyword=Pathogenicity island kn-keyword=Pathogenicity island en-keyword=Pseudomonas syringae kn-keyword=Pseudomonas syringae en-keyword=Tabtoxin kn-keyword=Tabtoxin END start-ver=1.4 cd-journal=joma no-vol=183 cd-vols= no-issue= article-no= start-page=111902 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202605 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Monitoring postharvest water loss in eggplants (Solanum melongena L.) using UV-induced fluorescence imaging and multivariate analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eggplant (Solanum melongena L.) is susceptible to significant postharvest losses primarily due to water loss during storage, which affects market quality by causing texture and glossiness degradation. We investigated whether UV-induced fluorescence imaging and EEM (Excitation-Emission Matrix) fluorescence spectroscopy can non-destructively monitor WL under four storage regimes (10 ‹C/95 % RH, 20 ‹C/95 % RH, 20 ‹C/75 % RH, 10 ‹C/75 % RH). EEMs exhibited three regions; a 365/420 nm blue emission increased most under warm, low-humidity storage and is consistent with phenolic/lignin-related fluorescence. Side-view fluorescence (FL) images showed progressive blue-white emission and surface textural changes that tracked gravimetric water loss (WL). A PLSR model using combined color and texture features from FL and reflectance (CL) images achieved R2CV = 0.88 (RMSECV = 3.47 %) with only six features. To test a minimal predictor, we fit an Analysis of Covariance (ANCOVA) using Day-1 FL MeanBlue as a covariate and storage category as a factor with Leave One Out Cross-validation (LOOCV); this forecasted cumulative WL with R2LOOCV = 0.92 and MAE = 1.88 %. Importantly, this ANCOVA model using Day-1 blue-band fluorescence as a covariate was predictive only under 20 ‹C/75 % RH; under the other conditions, its contribution was weak. Linear Discriminant Analysis (LDA) and Support Vector Machine (SVM) models achieved accuracies of 94.4 % and 85.2 %, respectively, in differentiating storage conditions. These results support low-cost FL imaging as a practical tool to monitor WL and storage stress. en-copyright= kn-copyright= en-aut-name=RotichVincent en-aut-sei=Rotich en-aut-mei=Vincent kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=GaoTianqi en-aut-sei=Gao en-aut-mei=Tianqi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=PrempreePanintorn en-aut-sei=Prempree en-aut-mei=Panintorn kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HayashiTakahiro en-aut-sei=Hayashi en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NambaKazuhiko en-aut-sei=Namba en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MontaMitsuji en-aut-sei=Monta en-aut-mei=Mitsuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NishimotoMotomi en-aut-sei=Nishimoto en-aut-mei=Motomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KondoNaoshi en-aut-sei=Kondo en-aut-mei=Naoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Laboratory of Biosensing Engineering, Graduate School of Agriculture, Kyoto University kn-affil= affil-num=2 en-affil=Laboratory of Biosensing Engineering, Graduate School of Agriculture, Kyoto University kn-affil= affil-num=3 en-affil=Laboratory of Biosensing Engineering, Graduate School of Agriculture, Kyoto University kn-affil= affil-num=4 en-affil=Laboratory of Biosensing Engineering, Graduate School of Agriculture, Kyoto University kn-affil= affil-num=5 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=7 en-affil=Technology and Innovation Center, Daikin Industries, Ltd. kn-affil= affil-num=8 en-affil=Laboratory of Biosensing Engineering, Graduate School of Agriculture, Kyoto University kn-affil= en-keyword=Eggplant kn-keyword=Eggplant en-keyword=Fluorescence spectroscopy kn-keyword=Fluorescence spectroscopy en-keyword=UV-Induced imaging kn-keyword=UV-Induced imaging en-keyword=Water loss kn-keyword=Water loss en-keyword=Postharvest quality kn-keyword=Postharvest quality en-keyword=Non-destructive assessment kn-keyword=Non-destructive assessment END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=713 article-no= start-page=13 end-page=21 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=2026 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=wŒõ‚ªŒ©‚¦‚éxlH–Ô–Œ‚̉”\« \ —L‹@F‘f•ªŽq‚ð•”Þ‚Æ‚·‚颊E‰‚̈ã—Ë@ŠíuŒõ“d•ÏŠ·F‘f”––ŒŒ^lH–Ô–ŒOURePv en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–Ô–ŒF‘f•Ï«‚â‰Á—”Á•Ï«‚Å‚ÍAŒõ‚ð×–E–Œ“dˆÊ‚É•ÏŠ·‚·‚é–Ô–ŒŽ‹×–E‚ªŽ€‚ñ‚Å‚¢‚邪AŽ‹_Œo‚Æ‚µ‚Ä”]‚ɘA—‚·‚é_Œoß×–E‚Ͷ‚«Žc‚Á‚Ä‚¢‚éBlH–Ô–Œ‚ÍŽ‹×–E‚ð‘ã‘Ö‚·‚élH•¨‚ÅAŒõ‚ðŽó‚¯“d—¬‚ðo—Í‚·‚é“d‹ÉƒAƒŒƒCŒ^‚ªŽå—¬‚Å‚ ‚邪A“d—¬‚ÍŠgŽU‚·‚邽‚߉𑜓xŒüオ“‚¢B‚»‚±‚ÅlH–Ô–Œ‚̉𑜓xŒüã‚ð–ÚŽw‚µ‚ÄAŒõ‚ð“dˆÊ·‚É•ÏŠ·‚·‚éŒõ“d•ÏŠ·F‘f•ªŽq‚ð≑̂̃|ƒŠƒGƒ`ƒŒƒ“”––Œ•\–Ê‚É‹¤—LŒ‹‡‚µ‚½Œõ“d•ÏŠ·F‘f”––ŒŒ^‚ÌlH–Ô–ŒOUReP‚ðŠJ”­‚µ‚Ä‚«‚½B‚±‚ÌlH–Ô–ŒOUReP‚ÍŒõŽó—e‚Æ“dˆÊo—͂̈ê‘ÌŒ^‚ÅŠO•”‹N“d—Í‚Í•s—vAŽèp‚Å‚Í”––Œ‚ðçõ‚ÅØ‚Á‚ÄŠá“à‚ÉAž‚Þ‘å‚«‚³‚ðŽ©—R‚É‘I‚ׂéBŽg‚¢ŽÌ‚ăCƒ“ƒWƒFƒNƒ^‚ðŽg‚Á‚Ä”––Œ‚ðŠÛ‚ߊዅ‚Ì–Ô–Œ‰º‚ÉÉŽq‘ÌŽèp‚ÅAž‚ÝA–Ô–Œ‰º‚ÉAž‚ñ‚¾lH–Ô–ŒOUReP‚ÍŒõ‚ðŽó‚¯‚Ä“dˆÊ·‚ðo—Í‚µ—×Ú‚·‚é–Ô–Œ‘gD‚Ì_Œo×–E‚ÌŠˆ“®“dˆÊ‚ð—U”­‚·‚éBƒNƒŠ[ƒ“ƒ‹[ƒ€‚Å»‘¢•iŽ¿ŠÇ—‚ðs‚¢AˆÀ‘S«‚Æ—LŒø«‚ðØ–¾‚µ‚ÄAˆãŽtŽå“±Ž¡Œ±‚ð€”õ‚µ‚Ä‚¢‚éB¡ŒãA“ú–{‚Ì‘–¯ŠF•ÛŒ¯‚ªˆÛŽ‚Å‚«‚é‚悤”äŠrˆÀ‰¿‚È“K³‰¿Ši‚ÌlH–Ô–ŒŽ¡—Âð’ñ‹Ÿ‚µ‚½‚¢B en-copyright= kn-copyright= en-aut-name=MatsuoToshihiko en-aut-sei=Matsuo en-aut-mei=Toshihiko kn-aut-name=¼”ör•F kn-aut-sei=¼”ö kn-aut-mei=r•F aut-affil-num=1 ORCID= en-aut-name=UchidaTetsuya en-aut-sei=Uchida en-aut-mei=Tetsuya kn-aut-name=“à“c“N–ç kn-aut-sei=“à“c kn-aut-mei=“N–ç aut-affil-num=2 ORCID= en-aut-name=IshikaneHiroshi en-aut-sei=Ishikane en-aut-mei=Hiroshi kn-aut-name=΋à_Žj kn-aut-sei=΋à kn-aut-mei=_Žj aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŠÂ‹«¶–½Ž©‘R‰ÈŠwŠwˆæ affil-num=3 en-affil= kn-affil=êC‘åŠwlŠÔ‰ÈŠw•”S—Šw‰È en-keyword=lH–Ô–Œ kn-keyword=lH–Ô–Œ en-keyword=Œõ“d•ÏŠ·F‘f kn-keyword=Œõ“d•ÏŠ·F‘f en-keyword=ˆãŽtŽå“±Ž¡Œ± kn-keyword=ˆãŽtŽå“±Ž¡Œ± en-keyword=–Ô–ŒŠˆ“®“dˆÊ kn-keyword=–Ô–ŒŠˆ“®“dˆÊ en-keyword=»‘¢•iŽ¿ŠÇ— kn-keyword=»‘¢•iŽ¿ŠÇ— END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue=1 article-no= start-page=pgaf393 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251222 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Chloroplast heat shock protein cpHsc70-1 interacts with thylakoid membrane remodeling protein VIPP1 C-terminal tail and controls VIPP1 oligomer assembly en-subtitle= kn-subtitle= en-abstract= kn-abstract=Oxygenic photosynthetic organisms depend on the thylakoid membranes (TMs) for light-driven energy conversion. Recent studies on TM homeostasis (thylakostasis) have highlighted the essential role of the TM remodeling protein vesicle-inducing protein in plastid 1 (VIPP1). As a member of the endosomal sorting complexes required for transport-III (ESCRT-III)/phage shock protein A (PspA)/VIPP1 superfamily, VIPP1 forms large ring- and filament-like homo-oligomeric structures that exhibit a membrane remodeling activity. The oligomerization status was proposed to be modulated by the intrinsically disordered C-terminal tail (Vc), whereas its functional role remained unclear. Notably, this Vc region is conserved not only in photosynthetic VIPP1 but also in the PspA proteins of extremophilic species, implicating its role in membrane stress responses. To investigate the role of the Vc region in VIPP1 assembly, we performed coimmunoprecipitation assays in Arabidopsis chloroplasts and identified chloroplast-localized HSP70 proteins (cpHsc70) as major interactors. Among the two isoforms, cpHsc70-1 was found to be specifically required for modulating VIPP1 oligomeric assembly and dynamics in response to heat stress. Genetic analyses revealed that cpHsc70-1 facilitates the disassembly of VIPP1 oligomers, similarly to Vps4 ATPase in ESCRT-III; loss of either the Vc region or cpHsc70-1-impaired VIPP1 disassembly, resulting in more static oligomeric structures. Furthermore, cpHsc70-1 exhibited a broader role in chloroplast proteostasis, as the cphsc70-1 mutant showed impaired accumulation of green fluorescent protein (GFP)-fusion proteins. Together, our findings uncover a crucial crosstalk between proteostasis and thylakostasis in chloroplasts, coordinated by cpHsc70-1 and VIPP1 in response to membrane stress. en-copyright= kn-copyright= en-aut-name=LiDi en-aut-sei=Li en-aut-mei=Di kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=GachieSarah Wanjiru en-aut-sei=Gachie en-aut-mei=Sarah Wanjiru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OzawaShin-ichiro en-aut-sei=Ozawa en-aut-mei=Shin-ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ScholzMartin en-aut-sei=Scholz en-aut-mei=Martin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HipplerMichael en-aut-sei=Hippler en-aut-mei=Michael kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SakamotoWataru en-aut-sei=Sakamoto en-aut-mei=Wataru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=2 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=3 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=4 en-affil=Institute of Plant Biology and Biotechnology, University of M?nster kn-affil= affil-num=5 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=6 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= en-keyword=Arabidopsis thaliana kn-keyword=Arabidopsis thaliana en-keyword=chloroplast kn-keyword=chloroplast en-keyword=heat shock protein kn-keyword=heat shock protein en-keyword=photosynthesis kn-keyword=photosynthesis en-keyword=thylakoid membrane remodeling kn-keyword=thylakoid membrane remodeling END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=2 article-no= start-page=444 end-page=451 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202602 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Interactive Effects of Maximum Daytime and Minimum Nighttime Temperatures on Spinach Growth and Physiological Characteristics en-subtitle= kn-subtitle= en-abstract= kn-abstract=High temperatures restrict spinach growth, and the plantfs growth and physiological responses to heat remain poorly understood. It remains unclear whether high daytime or elevated nighttime temperatures have a more negative impact on spinach growth. In addition, the interaction effect of maximum daytime and minimum nighttime temperatures on spinach growth remains unknown. This study was conducted to address these issues. Spinach was grown in controlled environments under four temperature treatments: 30 and 20 ‹C (T30/20), 30 and 25 ‹C (T30/25), 35 and 20 ‹C (T35/20), and 35 and 25 ‹C (T35/25). These treatments represent the maximum daytime temperature and minimum nighttime temperature, respectively, and were maintained for 45 days. Plant growth characteristics were monitored, and the physiological responses to temperature regimes were assessed. The results show that compared with T30/20, dry matter production decreased by 15.4% with increased nighttime temperature (T30/25), decreased by 42.3% with increased daytime temperature (T35/20), and decreased by 57.7% when both daytime and nighttime temperatures were increased (T35/25). However, there was no statistically significant interaction effect (P > 0.05) between daytime maximum and nighttime minimum temperatures on plant biomass production variables. In comparison with T30/20, the T35/25 treatment increased significantly plant stomatal conductance, stomatal apertures, transpiration rate, and leaf temperature during heat waves. The T35/25 treatment also decreased the quantum efficiency in light compared with the other treatments. Plant biomass production did not improve with the T35/20 and T35/25 treatments, likely as a result of a decoupling of photosynthesis and stomatal conductance during heat waves. Overall, these results reveal that maximum daytime and minimum nighttime temperatures exert additive effects on spinach growth. en-copyright= kn-copyright= en-aut-name=SambaNethone en-aut-sei=Samba en-aut-mei=Nethone kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AkasakaHisao en-aut-sei=Akasaka en-aut-mei=Hisao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YasubaKen-ichiro en-aut-sei=Yasuba en-aut-mei=Ken-ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GotoTanjuro en-aut-sei=Goto en-aut-mei=Tanjuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=Hikawa-EndoMinori en-aut-sei=Hikawa-Endo en-aut-mei=Minori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyamaYoko en-aut-sei=Miyama en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Faculty of Food and Agricultural Sciences, Fukushima University kn-affil= affil-num=2 en-affil=The United Graduate School of Agricultural Sciences, Iwate University, Iwate, 020-8550, Japan; and Iwate Agricultural Research Center, Kenpoku Agricultural Research Institute kn-affil= affil-num=3 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=6 en-affil=Faculty of Food and Agricultural Sciences, Fukushima University, Fukushima, 960-1296, Japan; and The United Graduate School of Agricultural Sciences, Iwate University kn-affil= en-keyword=photosynthesis kn-keyword=photosynthesis en-keyword=quantum efficiency kn-keyword=quantum efficiency en-keyword=stomatal aperture kn-keyword=stomatal aperture en-keyword=stomatal conductance kn-keyword=stomatal conductance en-keyword=transpiration kn-keyword=transpiration END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=4 article-no= start-page=522 end-page=529 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of Intermittent Low-temperature Storage Duration and Cycle on the Bolting and Flowering of Delphinium elatum in Summer en-subtitle= kn-subtitle= en-abstract= kn-abstract=Early-bolting in summer is a major problem when growing delphinium seedlings in summer to produce cut flowers that will be shipped in autumn and winter. In this study, an intermittent low-temperature storage (ILTS) treatment that induces flower bud differentiation in strawberry and prevents rosette formation in Eustoma significantly increased the Delphinium elatum cut flower length. Moreover, ILTS was as effective as growing seedlings under cool conditions at preventing early-bolting. We analyzed the effects of six ILTS treatments that differed regarding the treatment temperature (5 and 10‹C) and treatment cycle (3 days/3 days, 6 days/6 days, and 12 days/12 days; ambient conditions/cool and dark). Cut flowers were significantly longer with the 6 days/6 days treatment at 10‹C than for the control treatment. Furthermore, repeating the ILTS treatment cycle (6 days ambient conditions/6 days at 10‹C) a total of four times produced high-quality cut flowers regardless of the cultivar. Therefore, this ILTS treatment may be ideal for preventing early-bolting in D. elatum. en-copyright= kn-copyright= en-aut-name=KawaiMika en-aut-sei=Kawai en-aut-mei=Mika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukuyasuMiwa en-aut-sei=Fukuyasu en-aut-mei=Miwa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaYoshiyuki en-aut-sei=Tanaka en-aut-mei=Yoshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KitamuraYoshikuni en-aut-sei=Kitamura en-aut-mei=Yoshikuni kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YasubaKen-ichiro en-aut-sei=Yasuba en-aut-mei=Ken-ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YoshidaYuichi en-aut-sei=Yoshida en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=GotoTanjuro en-aut-sei=Goto en-aut-mei=Tanjuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Agriculture, Kyoto University kn-affil= affil-num=4 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=cool storage kn-keyword=cool storage en-keyword=cut flower quality kn-keyword=cut flower quality en-keyword=high ambient temperature kn-keyword=high ambient temperature en-keyword=long day kn-keyword=long day en-keyword=Ranunculaceae kn-keyword=Ranunculaceae END start-ver=1.4 cd-journal=joma no-vol=95 cd-vols= no-issue=1 article-no= start-page=10 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=2026 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comparison of Fruit Development, Ripening, and Transcriptome Dynamics in Taiwanese and Japanese Cultivars of Japanese Apricot (Prunus mume Sieb. et Zucc.) en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this study, we compared changes in traits associated with fruit development and ripening in Taiwanese and Japanese cultivars of Japanese apricot (Prunus mume Sieb. et Zucc.). We also analyzed transcriptome profiles to comprehensively examine different fruit development and ripening patterns between the two groups in terms of fruit characteristics and gene expression. Early fruit development in Taiwanese cultivars eSTf and eEllchingf and the Japanese cultivar eHakuof was ahead of that in other three Japanese cultivars (P1). From late April to early May, around the stone-hardening stage, the developmental differences decreased to the same level. Thereafter, Japanese cultivars showed rapid growth, whereas Taiwanese cultivars showed slower growth, reversing the developmental differences between these lines (P2). Ethylene production was not detected until the full ripening stage and was detected for the first time at this stage in five cultivars, except for eEllchingf (P3). In contrast, no ethylene production was observed during the entire duration of fruit development in eEllchingf. A multidimensional scaling plot showed that the overall transcriptome profile changed according to the three stages (P1?P3) of fruit development and ripening. At P1, gene ontologies (GOs) related to cell division, such as the cell cycle and regulation of cyclin-dependent protein serine/threonine kinase activity, were enriched for differentially expressed genes downregulated in Taiwanese cultivars as compared with their expression in Japanese cultivars. At P2, GOs related to fruit development were not enriched, but some genes related to phytohormones, such as auxin, abscisic acid, and cytokinin, which are associated with fruit development and ripening, were differentially expressed. At P3, the expression of genes such as ACS, ACO, and PG, which are involved in ethylene biosynthesis, increased in response to increased ethylene production, but not in eEllchingf, which showed no ethylene production. Expression analysis of 115 NAC (NAM-ATAF1/2-CUC2) family genes, which are related to fruit ripening and ripening date in other fruit species, in the eEllchingf genome revealed changes in expression of NAC056 and NAC073 corresponding to fruit development and ripening in Taiwanese and Japanese cultivars. We discuss the differences in fruit development and ripening behaviors between Taiwanese and Japanese cultivars in terms of physiological and transcriptome changes. en-copyright= kn-copyright= en-aut-name=KashiwamotoTomoaki en-aut-sei=Kashiwamoto en-aut-mei=Tomoaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KawaiTakashi en-aut-sei=Kawai en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OeTakaaki en-aut-sei=Oe en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NumaguchiKoji en-aut-sei=Numaguchi en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KitamuraYuto en-aut-sei=Kitamura en-aut-mei=Yuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KuboYasutaka en-aut-sei=Kubo en-aut-mei=Yasutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FukudaFumio en-aut-sei=Fukuda en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=UshijimaKoichiro en-aut-sei=Ushijima en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Japanese Apricot Laboratory, Wakayama Fruit Tree Experiment Station kn-affil= affil-num=4 en-affil=Japanese Apricot Laboratory, Wakayama Fruit Tree Experiment Station kn-affil= affil-num=5 en-affil=Faculty of Agriculture, Setsunan University kn-affil= affil-num=6 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=8 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= en-keyword=cell division kn-keyword=cell division en-keyword=ethylene production kn-keyword=ethylene production en-keyword=NAC kn-keyword=NAC en-keyword=phytohormone kn-keyword=phytohormone en-keyword=stone hardening kn-keyword=stone hardening END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue= article-no= start-page=53 end-page=64 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Sixteen-Year Chronicle of Service as Mayor of Setouchi City kn-title=£ŒË“àŽs’·‚Æ‚µ‚Ä‚Ì16”NŠÔ‚Ì‚ ‚ä‚Ý \ Žs’·‚̈ӎvŒˆ’è \ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TAKEHISAAkinari en-aut-sei=TAKEHISA en-aut-mei=Akinari kn-aut-name=•‹vŒ°–ç kn-aut-sei=•‹v kn-aut-mei=Œ°–ç aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‘O£ŒË“àŽs’· END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue= article-no= start-page=1 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Current situation and issues of core organization in Adult Gurdianship System kn-title=¬”NŒãŒ©§“x@`’†Šj‹@ŠÖ‚ÌŒ»ó‚Ɖۑè` en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NISHIDAKazuhiro en-aut-sei=NISHIDA en-aut-mei=Kazuhiro kn-aut-name=¼“c˜aO kn-aut-sei=¼“c kn-aut-mei=˜aO aut-affil-num=1 ORCID= en-aut-name=NISHIYAMAMika en-aut-sei=NISHIYAMA en-aut-mei=Mika kn-aut-name=¼ŽRŽO‰À kn-aut-sei=¼ŽR kn-aut-mei=ŽO‰À aut-affil-num=2 ORCID= en-aut-name=NAGASHIOAyaka en-aut-sei=NAGASHIO en-aut-mei=Ayaka kn-aut-name=’·‰–Ê kn-aut-sei=’·‰– kn-aut-mei=Ê aut-affil-num=3 ORCID= en-aut-name=YOSHIOKAKyosuke en-aut-sei=YOSHIOKA en-aut-mei=Kyosuke kn-aut-name=‹g‰ª‹œ—S kn-aut-sei=‹g‰ª kn-aut-mei=‹œ—S aut-affil-num=4 ORCID= en-aut-name=IMAITomono en-aut-sei=IMAI en-aut-mei=Tomono kn-aut-name=¡ˆä—F”T kn-aut-sei=¡ˆä kn-aut-mei=—F”T aut-affil-num=5 ORCID= en-aut-name=MIZUTAYuji en-aut-sei=MIZUTA en-aut-mei=Yuji kn-aut-name=…“c—Y“ñ kn-aut-sei=…“c kn-aut-mei=—Y“ñ aut-affil-num=6 ORCID= en-aut-name=UCHIDADaisuke en-aut-sei=UCHIDA en-aut-mei=Daisuke kn-aut-name=“à“c‘å‰î kn-aut-sei=“à“c kn-aut-mei=‘å‰î aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@–@–±Œ¤‹†‰È affil-num=2 en-affil=Okayama City Adult Gurdianship Center Case kn-affil=‰ªŽRŽsŽÐ‰ï•ŸŽƒ‹¦‹c‰ï‰ªŽRŽs¬”NŒãŒ©ƒZƒ“ƒ^[ affil-num=3 en-affil=Okayama City Adult Gurdianship Center Case kn-affil=‰ªŽRŽsŽÐ‰ï•ŸŽƒ‹¦‹c‰ï‰ªŽRŽs¬”NŒãŒ©ƒZƒ“ƒ^[ affil-num=4 en-affil=Soja City Case kn-affil=‘ŽÐŽsŽÐ‰ï•ŸŽƒ‹¦‹c‰ï affil-num=5 en-affil=Chita Area Avocacy Center Case kn-affil=’m‘½’nˆæŒ —˜—iŒìŽx‰‡ƒZƒ“ƒ^[ affil-num=6 en-affil=Oda City Case kn-affil=‘å“cŽsŽÐ‰ï•ŸŽƒ‹¦‹c‰ï‘å“cŽs¬”NŒãŒ©ƒZƒ“ƒ^[ affil-num=7 en-affil=Oda City Case kn-affil=‘å“cŽs‰îŒì•ÛŒ¯‰Û END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue= article-no= start-page=13 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The List of Published by Members of the Faculty From January to December 2025. kn-title=Œö•\Šwp˜_•¶“™ƒŠƒXƒg@2025 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue= article-no= start-page=9 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260301 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Soil nitrogen dynamics affected by the fine roots of canopy trees in Eastern Hokkaido, Japan kn-title=–kŠC“¹“Œ•”‚ÌX—Ñ‚É‚¨‚¢‚Ä—ÑŠ¥–Ø‚Ìת‚ª“yë’‚‘f“®‘Ô‚É—^‚¦‚é‰e‹¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@Plants release mixtures of labile organic matter from their fine roots (root exudates) into the surrounding soil (rhizosphere). Partly due to the release of root exudates, microbial community structures and their activities within the rhizosphere differ significantly from those in other soil areas (bulk soil). Consequently, nutrient cycling processes, including nitrogen mineralization, are accelerated in the rhizosphere, facilitating nutrient acquisition by plants. This phenomenon, known as the rhizosphere effect, has been repeatedly reported in studies of herbaceous plants; however, the impact of canopy tree fine roots on soil nitrogen dynamics through the effect in forest ecosystems remains largely unknown. Here, I introduce our research investigating the root exudates and rhizosphere effects of the fine roots of canopy trees, Quercus crispula, and how these fine roots affect soil nitrogen dynamics. The quantity of root exudates varied daily rather than seasonally, with solar radiation having a strong and positive effect on the amounts. However, even after leaf fall, root exudation was observed. In the rhizosphere, specific bacterial communities were present regardless of season, while ectomycorrhizal fungal populations were higher than in the bulk soil only in summer. Extracellular enzymatic activity relating to nitrogen cycling was higher in the rhizosphere than in the bulk soil across seasons. Nitrogen uptake by the tree was likely lower in winter and spring, leading to labile nitrogen accumulation in the rhizosphere during these periods. On an annual basis, however, the impact of fine roots on apparent inorganic nitrogen dynamics was minor. These results suggest that the canopy tree, Q. crispula, accelerates soil nitrogen cycling through root exudation and rhizosphere effects, regardless of season, while the acceleration of the cycle and the utilization of available nitrogen are well-balanced annually, thereby avoiding unnecessary carbon investment. en-copyright= kn-copyright= en-aut-name=NakayamaMasataka en-aut-sei=Nakayama en-aut-mei=Masataka kn-aut-name=’†ŽR—’q kn-aut-sei=’†ŽR kn-aut-mei=—’q aut-affil-num=1 ORCID= affil-num=1 en-affil=Course of Environmental Ecology kn-affil=ŠÂ‹«¶‘ÔŠwƒR[ƒX en-keyword=Quercus crispula kn-keyword=Quercus crispula en-keyword=root exudates kn-keyword=root exudates en-keyword=rhizosphere effect kn-keyword=rhizosphere effect en-keyword=nitrogen dynamics kn-keyword=nitrogen dynamics en-keyword=nitrogen uptake kn-keyword=nitrogen uptake END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue= article-no= start-page=145 end-page=154 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260220 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Chi no Tanken (Inquiries of Knowledge) meets Multicultural Collaborative LearningFTransforming a Japanese Online Course for Global Learners kn-title=u’m‚Ì’TŒ¤v~ ‘½•¶‰»‹¤C \ƒIƒ“ƒ‰ƒCƒ“Žö‹ÆÄ\’z‚ÌŽŽ‚Ý\ en-subtitle= kn-subtitle= en-abstract=Okayama University launched a new undergraduate curriculum in April 2025. As part of this reform, Chi no Tanken, a general education course required for incoming students, was introduced. This paper reports on the first-year implementation of the course, offered in English as Inquiries of Knowledge, for students in the Discovery Program for Global Learners, many of whom are international students. Reconstructing the on-demand online course from a multicultural collaborative learning perspective required more than simply translating the materials into English. It also necessitated developing pedagogical strategies to foster collaborative learning in the online environment and to integrate linguistic and cultural considerations. kn-abstract=‰ªŽR‘åŠw‚Å‚Í2025”N4ŒŽ“üŠw¶‚©‚çVƒJƒŠƒLƒ…ƒ‰ƒ€‚ªƒXƒ^[ƒg‚µ‚½BŠwŽm‰Û’ö‰üŠv‚̈êŠÂ‚Æ‚µ‚Ä“±“ü‚³‚ꂽ‚Ì‚ª‘SŠw‹¤’ÊE‰Û‘è’T‹†‰È–Úu’m‚Ì’TŒ¤v‚Å‚ ‚éB–{e‚Å‚ÍCV“ü¶‘ÎۉȖڂł ‚éu’m‚Ì’TŒ¤v‚ðCŠCŠO¶‚ðŠÜ‚ÞƒOƒ[ƒoƒ‹EƒfƒBƒXƒJƒoƒŠ[EƒvƒƒOƒ‰ƒ€¶Œü‚¯‚ɉpŒê‚Å gInquiries of Knowledgeh ‚Æ‚µ‚ÄŠJu‚µ‚½‰”N“x‚ÌŽæ‚è‘g‚Ý‚ð•ñ‚·‚éB‚Æ‚è‚킯ƒIƒ“ƒfƒ}ƒ“ƒhŒ^ƒIƒ“ƒ‰ƒCƒ“Žö‹Æ‚ð, –{Šw‚ª„i‚·‚鑽•¶‰»‹¤C‚ÌŽ‹“_‚ÅÄ\’z‚·‚é‚É‚ ‚½‚èC‹³Þ‚ð’P‚ɉp–ó‚·‚é‚Ì‚Å‚Í‚È‚­, ƒIƒ“ƒ‰ƒCƒ“ŠÂ‹«‚É‚¨‚¢‚Ä‚à‹¦“­ŠwK‚ðŽÀŒ»‚·‚éH•v‚âCŒ¾Œê“IE•¶‰»“I”z—¶‚Ì“‡‚ª•s‰ÂŒ‡‚Å‚ ‚邱‚Ƃ𖾂炩‚É‚·‚éB en-copyright= kn-copyright= en-aut-name=YAMAMOTOYumiko en-aut-sei=YAMAMOTO en-aut-mei=Yumiko kn-aut-name=ŽR–{—R”üŽq kn-aut-sei=ŽR–{ kn-aut-mei=—R”üŽq aut-affil-num=1 ORCID= en-aut-name=NGUYENKha Manh en-aut-sei=NGUYEN en-aut-mei=Kha Manh kn-aut-name=ƒOƒGƒ“?ƒJ?ƒ}ƒ“ kn-aut-sei=ƒOƒGƒ“? kn-aut-mei=ƒJ?ƒ}ƒ“ aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of General and Global Studies (GDP), Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ ‹¤’Ê‹³ˆçEƒOƒ[ƒoƒ‹—̈æiGDPj affil-num=2 en-affil=Discovery Program for Global Learners, Okayama University kn-affil=‰ªŽR‘åŠwƒOƒ[ƒoƒ‹EƒfƒBƒXƒJƒoƒŠ[EƒvƒƒOƒ‰ƒ€ en-keyword=‘½•¶‰»‹¤C kn-keyword=‘½•¶‰»‹¤C en-keyword=‹¦“­ŠwK kn-keyword=‹¦“­ŠwK en-keyword=’T‹†Œ^ŠwK kn-keyword=’T‹†Œ^ŠwK en-keyword=ƒIƒ“ƒfƒ}ƒ“ƒhŒ^ƒIƒ“ƒ‰ƒCƒ“Žö‹Æ kn-keyword=ƒIƒ“ƒfƒ}ƒ“ƒhŒ^ƒIƒ“ƒ‰ƒCƒ“Žö‹Æ END start-ver=1.4 cd-journal=joma no-vol=779 cd-vols= no-issue= article-no= start-page=110775 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202605 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comparison of bioavailability of quercetin and its structural analogs in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Flavonoids are thought to provide beneficial effects on health. However, there are still uncertainties regarding their bioavailability. In this study, we investigated the bioavailability of 6 flavonoids, galangin, kaempferol, quercetin, myricetin, fisetin, and luteolin, by oral administration to mice. Analysis of plasma concentrations of free flavonoids after deconjugation by LC-MS/MS revealed that all flavonoids were rapidly absorbed after administration. Among 6 flavonoids, kaempferol and fisetin showed high absorbed amounts in blood plasma. With the LogP value of the two flavonoids as the maximum value, the amount absorbed decreased for both lower and higher LogP values. The results of the tissue distribution of galangin, kaempferol, and quercetin suggested that the order of fastest movement from the stomach to the small intestine was kaempferol?>?quercetin?>?galangin. In addition, the amount of kaempferol and quercetin distributed in the liver was greater than that of galangin. These results suggest that the bioavailability of flavonoids varies with the slight structural differences, possibly due to differences in their rapid accessibility to the small intestine that is the primary site of absorption and metabolism within the body. en-copyright= kn-copyright= en-aut-name=MaedaNozomi en-aut-sei=Maeda en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HashimotoAtsushi en-aut-sei=Hashimoto en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MoritaRyosei en-aut-sei=Morita en-aut-mei=Ryosei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MunemasaShintaro en-aut-sei=Munemasa en-aut-mei=Shintaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MurataYoshiyuki en-aut-sei=Murata en-aut-mei=Yoshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakamuraYoshimasa en-aut-sei=Nakamura en-aut-mei=Yoshimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakamuraToshiyuki en-aut-sei=Nakamura en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= en-keyword=Flavonoid kn-keyword=Flavonoid en-keyword=Bioavailability kn-keyword=Bioavailability en-keyword=Distribution kn-keyword=Distribution END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=1 article-no= start-page=11 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260105 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association of Wet-Bulb Globe Temperature with heat-related illness hospitalizations in Japan: a time-stratified, case-crossover study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background Heat-related illnesses are a serious public health concern and are exacerbated by global warming. Wet-Bulb Globe Temperature (WBGT) is widely used as a heat stress indicator, but its clinical impact remains unclear. This study aimed to investigate the association between hourly variations in WBGT and the incidence of hospitalizations for heat-related illness in Japan using a nationwide database. By incorporating individual-level clinical data and performing stratified analyses, we sought to provide a more granular understanding of how heat exposure affects the risk of heat-related illness requiring hospitalization.
Methods We conducted a time-stratified, case-crossover study using data collected from July to September in 2020 and 2021 in the Heatstroke STUDY registry. The inclusion criteria were patients registered in the Heatstroke STUDY registry, specifically hospitalized patients with heat-related illness who were transported to participating hospitals during the study period. Hourly WBGT values were assigned based on the nearest monitoring station to each hospital. Conditional logistic regression and distributed lag models were used to estimate associations between WBGT and the risk of hospitalization.
Results A total of 1,653 heat-related illness hospitalizations were analyzed. The mean patient age was 67.9 years; 67.6% were male. Each 1 ‹C increase in WBGT at onset (hospital arrival) was associated with a significantly increased risk of hospitalization (OR 1.10, 95% CI: 1.05?1.15). The cumulative effect over the prior six hours was also significant (OR 1.56, 95% CI: 1.50?1.62). Compared with WBGT? Conclusions Higher WBGT levels were associated with an increased risk of heat-related hospitalization. Although the effect appeared greater in some subgroups, only patients with mental disorders demonstrated statistically significant effect modification, suggesting elevated WBGT confers risk broadly. en-copyright= kn-copyright= en-aut-name=YamamuraYuka en-aut-sei=Yamamura en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HongoTakashi en-aut-sei=Hongo en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YumotoTetsuya en-aut-sei=Yumoto en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SasaiFumiya en-aut-sei=Sasai en-aut-mei=Fumiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TokiokaKohei en-aut-sei=Tokioka en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ObaraTakafumi en-aut-sei=Obara en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NojimaTsuyoshi en-aut-sei=Nojima en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KandaJun en-aut-sei=Kanda en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YokoboriShoji en-aut-sei=Yokobori en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Department of Epidemiology, Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Epidemiology, Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Emergency and Critical Care Medicine, Nippon Medical School Musashikosugi Hospital kn-affil= affil-num=9 en-affil=Department of Emergency and Critical Care Medicine, Nippon Medical School kn-affil= affil-num=10 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Epidemiology, Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=Wet-Bulb Globe Temperature kn-keyword=Wet-Bulb Globe Temperature en-keyword=Heat stroke kn-keyword=Heat stroke en-keyword=Heat related illness kn-keyword=Heat related illness en-keyword=Global warming kn-keyword=Global warming END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260219 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Induction of IL-9-producing CD8+ T cells by ascochlorin derivatives en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background and Purpose: Ascochlorin (ASC) is an antiviral antibiotic from the fermented broth of Ascochyta viciae which exerts an inhibitory effect to cancers. Its impact on immune cells has not been examined. In this study, we obtained ASC derivatives with less cytotoxicity and determined whether they affected T cells, indicating possible immune-mediated antitumour effects.
Experimental Approach: Newly synthesised ASC derivatives were screened for inhibitory effects on T-cell antigen receptor (TCR)-stimulated proliferative responses using murine CD4+ and CD8+ T cells. Two compounds were identified that exhibited >10-fold less toxicity compared with ASC. N184, the less toxic of the two, was analysed for its in vivo antitumour effects, and in vitro effects on CD8+ T-cell proliferation, survival, cytokine production and exhaustion, using microscopy, qPCR and flow cytometry.
Key Results: N184 induced limited IL-9 production in CD8+ T cells following TCR stimulation, thereby improving cell survival. It also enhanced cytokine production in the late phase of proliferation and suppressed the induction of exhaustion. N184 suppressed tumour growth in mice in a CD8+ T cell-dependent manner. The effect was partially prevented by an IL-9-neutralising antibody.
Conclusion and Implications: N184 induces differentiation of IL-9-producing CD8+ T cells in vitro and elicits antitumour immunity in an IL-9-dependent manner. en-copyright= kn-copyright= en-aut-name=ImanoNatsumi en-aut-sei=Imano en-aut-mei=Natsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishidaMikako en-aut-sei=Nishida en-aut-mei=Mikako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TokumasuMiho en-aut-sei=Tokumasu en-aut-mei=Miho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ZhaoWeiyang en-aut-sei=Zhao en-aut-mei=Weiyang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamashitaNahoko en-aut-sei=Yamashita en-aut-mei=Nahoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UdonoHeiichiro en-aut-sei=Udono en-aut-mei=Heiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Immunology, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Metabolic Immune Regulation, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Immunology, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Immunology, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Metabolic Immune Regulation, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Metabolic Immune Regulation, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=ascochlorin derivative kn-keyword=ascochlorin derivative en-keyword=CD8 positive T lymphocytes kn-keyword=CD8 positive T lymphocytes en-keyword=cell survival kn-keyword=cell survival en-keyword=IFN-ƒÁ kn-keyword=IFN-ƒÁ en-keyword=interleukin-9 kn-keyword=interleukin-9 en-keyword=Tc9 kn-keyword=Tc9 en-keyword=tumour immunity kn-keyword=tumour immunity END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=286 end-page=288 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=David Graeber Pirate enlightment, or the real Libertalia kn-title=ƒfƒ”ƒBƒbƒhEƒOƒŒ[ƒo[ ’˜ Žðˆä—²Žj –ówŒ[–Ö‚ÌŠC‘¯‚½‚¿@‚ ‚é‚¢‚ÍŽÀÝ‚µ‚½ƒŠƒoƒ^ƒŠƒA‚Ì•¨Œêx en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SAWAYAMAMikako en-aut-sei=SAWAYAMA en-aut-mei=Mikako kn-aut-name=‘òŽR”ü‰ÊŽq kn-aut-sei=‘òŽR kn-aut-mei=”ü‰ÊŽq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw•¶–¾“®‘ÔŠwŒ¤‹†Š END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=279 end-page=285 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=OCHI Seiko Quantitative analysis of Northern Wei history kn-title=‘å’m¹Žq’˜wŒv—Ê“I•ªÍ‚ð—p‚¢‚½–ké°ŽjŒ¤‹†x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HASEGAWAHirokazu en-aut-sei=HASEGAWA en-aut-mei=Hirokazu kn-aut-name=’·’Jì‘å˜a kn-aut-sei=’·’Jì kn-aut-mei=‘å˜a aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=163 end-page=169 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Supplement: History and generative AI kn-title=•â˜_F—ðŽjŠw‚ƶ¬AI en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OCHISeiko en-aut-sei=OCHI en-aut-mei=Seiko kn-aut-name=‘å’m¹Žq kn-aut-sei=‘å’m kn-aut-mei=¹Žq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=–¼é‘åŠw—HŠw•” END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=54 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The trajectory of rural field research and modernization discourse in American area studies: The Intersection of the University of Michiganfs Center for Japanese Studies Okayama Field Station, J. W. Hall, and the Seto Inland Sea Cultural Research Group kn-title=Area Studies ‚Ì‚È‚©‚Ìu’nˆæŽjvŒ¤‹† [—ðŽjŒ¤‹†ŽÒAJEWEƒz[ƒ‹‚©‚猩‚éƒ~ƒVƒKƒ“‘剪ŽR•ªŽº‚Æ£ŒË“àŠC‘‡Œ¤‹†‰ï[ en-subtitle= kn-subtitle= en-abstract= kn-abstract=During the late Allied occupation and the 1950s, the University of Michiganfs Center for Japanese Studies established a field station in Okayama, where American scholars conducted rural research. This article examines the challenges of academic research under occupation and analyzes how such research was organized through specific actors and institutional arrangements, with particular attention to its intersection with the academic knowledge of the host institution, Okayama University. Focusing on the historian John W. Hall, it traces the activities of the Michigan field station and explores its interactions with Okayama University and the Seto Inland Sea Cultural Research Group. The article argues that while archival research?understood as a form of fieldwork?facilitated collaborative research, differing conceptions of rural society constituted a critical point of divergence in the production of scholarly knowledge. en-copyright= kn-copyright= en-aut-name=OSAShizue en-aut-sei=OSA en-aut-mei=Shizue kn-aut-name=’·ŽuŽìŠG kn-aut-sei=’· kn-aut-mei=ŽuŽìŠG aut-affil-num=1 ORCID= affil-num=1 en-affil=Kobe University kn-affil= en-keyword=Michigan CJS Okayama Field Station kn-keyword=Michigan CJS Okayama Field Station en-keyword=John W. Hall kn-keyword=John W. Hall en-keyword=the Seto Inland Sea Cultural Research Group kn-keyword=the Seto Inland Sea Cultural Research Group en-keyword=Sumio Taniguchi kn-keyword=Sumio Taniguchi en-keyword=Rural Field Research kn-keyword=Rural Field Research en-keyword=Modernization Discourse kn-keyword=Modernization Discourse END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=1 end-page=19 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The gRussian Fluh pandemic in Japan, 1889-1891: A social-historical perspective kn-title=“ú–{‚É‚¨‚¯‚éuƒƒVƒA‚©‚ºv—¬s‚̎ЉïŽj“I•ªÍ \1889 -1891 ”Nƒpƒ“ƒfƒ~ƒbƒN‚Æ“ú–{ŽÐ‰ï\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study offers a social-historical analysis of the gRussian fluh pandemic in Japan (1889?1891). Due to scarce statistical data, the study relies primarily on contemporary newspapers and magazines. It identifies two distinct epidemic waves: the first in spring-summer 1890, and the second from late 1890 to spring 1891. The first wave, though widespread, was overshadowed by a concurrent cholera epidemic and caused relatively few deaths, whereas the second wave was far more lethal and generated widespread fear. At the time, influenza remained an gunknown diseaseh, with unclear etiology and no established treatments. People responded with diverse measures, from purchasing patent medicines and using folk remedies to symbolic practices such as "disease naming" (osome-kaze). The crisis also renewed attention to historical records of earlier influenza-like epidemics in Japan. In contrast, by the time of the later gSpanish fluh pandemic, advances in bacteriology had already rendered influenza a medically defined disease. This comparison highlights how shifting medical knowledge shaped societal responses. The findings not only corroborate previous excess-mortality analyses but also provide new historical insights into how societies have historically confronted pandemics. en-copyright= kn-copyright= en-aut-name=KAWAUCHIAtsushi en-aut-sei=KAWAUCHI en-aut-mei=Atsushi kn-aut-name=ì“à~Žj kn-aut-sei=ì“à kn-aut-mei=~Žj aut-affil-num=1 ORCID= affil-num=1 en-affil=Uehiro Disaster Risk Reduction Research Division, International Research Institute of Disaster Science (IRIDeS), TOHOKU UNIVERSITY kn-affil= en-keyword=Russian flu kn-keyword=Russian flu en-keyword=influenza pandemic kn-keyword=influenza pandemic en-keyword=epidemic waves kn-keyword=epidemic waves en-keyword=social history kn-keyword=social history en-keyword=unknown disease kn-keyword=unknown disease en-keyword=modern Japan kn-keyword=modern Japan END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=02 article-no= start-page=113 end-page=125 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=2026 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical genetics in comitant strabismus and idiopathic superior oblique muscle palsy kn-title=ŽÎŽ‹‚̈â“`ŽqŒ¤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract=‹¤“¯«ŽÎŽ‹‚͈â“`—vˆö‚Ɗ‹«—vˆö‚©‚ç‚Ȃ鑽ˆöŽqŽ¾Š³‚ÅA“àŽÎŽ‹‚ÆŠOŽÎŽ‹‚É‘å•Ê‚³‚ê‚éBˆâ“`—vˆö‚͉Ƒ°—ðAˆê—‘«‘o¶Ž™‚Ì•\Œ»Œ^ˆê’v—¦‚©‚焒肳‚êAŠÂ‹«—vˆö‚É‚Í”DPE•ª•ØŽž‚Ì’áŽ_‘fó‘Ô‚ª‚ ‚éBˆê•ûAˆâ“`—vˆö‚ª‚ ‚é”ñ‹¤“¯«i–ƒáƒ«jŽÎŽ‹‚Æ‚µ‚ÄãŽÎ‹ØäF’áŒ`¬‚ð’æ‚·‚é“Á”­«ãŽÎ‹Ø–ƒáƒ‚ª‚ ‚éBˆâ“`“ŒvŠw‚̘A½‰ðÍ‚ðŽg‚Á‚ÄA“àŽÎŽ‹‚ÆŠOŽÎŽ‹‚̬‰ÆŒnŒQ‚Å4”ÔõF‘ÌMGST2‚ðŽ¾Š³Š´Žó«ˆâ“`ŽqŒó•â‚Æ“¯’肵AMGST2ƒmƒbƒNƒAƒEƒgƒ}ƒEƒX‚ð쬂µ‚½B¬“®•¨—pMRI‚ʼnðÍ‚·‚é‚ÆA‚»‚̃zƒ‚Ú‡‘̂ł͖춌^‚Æ”ä‚ׂĊዅŒ`󂪗LˆÓ‚ɉ¡’·‚Å‘ÌÏ‚ª‘å‚«‚¢‚±‚Æ‚ðŒ©o‚µ‚½BŽŸ‚¢‚ňâ“`“ŒvŠw•Ê–@‚Ì‘SƒQƒmƒ€ŠÖ˜A‰ðÍ‚ð“àŽÎŽ‹AŠOŽÎŽ‹A“Á”­«ãŽÎ‹Ø–ƒáƒ‚ð‘ÎÛ‚Æ‚µ‚Äs‚Á‚½BInfinium Asian Screening Array-24 v1.0‚ÅSNP‚ðŒˆ‚ß‚½“àŽÎŽ‹253ŒŸ‘ÌAŠOŽÎŽ‹356ŒŸ‘ÌAãŽÎ‹Ø–ƒáƒ102ŒŸ‘Ì‚ðŽ¾Š³ŒQ‚Æ‚µ‚½B‘ÎÆW’c‚Æ‚µ‚Ä‚ÍAƒoƒCƒIƒoƒ“ƒNƒWƒƒƒpƒ“ (BBJ) ‚ÌŽ¾Š³ŒQ‚Ƃ͈ႤƒAƒŒƒC(OmniExpress)‚ÅSNP‚ðŒˆ‚ß‚½182,476ŒŸ‘ÌuBBJ (180K)vAŽ¾Š³ŒQ‚Æ“¯‚¶ƒAƒŒƒC‚ÅSNP‚ðŒˆ‚ß‚½BBJ‚Ì53409ŒŸ‘ÌuBBJ (ASA)v‚¨‚æ‚Ñ’·•lƒRƒz[ƒg3570ŒŸ‘Ì‚ðŽg‚Á‚½B‚R‘ÎÆW’c‚Æ‚Ì”äŠr‚Å‹¤’Ê‚µ‚ÄŒŸo‚³‚ꂽˆâ“`Žq‚ÍAãŽÎ‹Ø–ƒáƒŒQ‚Å_Œo×–EˆÚ“®‚ÉŠÖ—^‚·‚éDAB1‚Å‚ ‚Á‚½BÅ‚à‘å‚«‚¢‘ÎÆW’cuBBJ (180K)v‚Æ‚Ì”äŠr‚Å‚Í“àŽÎŽ‹AŠOŽÎŽ‹AãŽÎ‹Ø–ƒáƒ‚ðŠÜ‚ÞŽ¾Š³ŒQ‘S‘Ì‚ÅŠá”­¶‚ÉŠÖ—^‚·‚éRARB (retinoic acid receptor ƒÀ) ‚ªŒŸo‚³‚ꂽBŽÎŽ‹ŠÖ˜Aˆâ“`Žq‚ÍŠá‹…Œ`‘Ô‚ÉŠÖ—^‚·‚é‰Â”\«‚ª‚ ‚éB“Á”­«ãŽÎ‹Ø–ƒáƒ‚Í‹¤“¯«ŽÎŽ‹‚Æ‚Í“Æ—§‚µ‚½Ž¾Š³‚Æ—‰ð‚³‚ê‚邪A‹¤’ʂ̈â“`Šî”Õ‚à‚ ‚é‚©‚à‚µ‚ê‚È‚¢B en-copyright= kn-copyright= en-aut-name=MatsuoToshihiko en-aut-sei=Matsuo en-aut-mei=Toshihiko kn-aut-name=¼”ör•F kn-aut-sei=¼”ö kn-aut-mei=r•F aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ en-keyword=‘o¶Ž™’²¸ kn-keyword=‘o¶Ž™’²¸ en-keyword=ŽÎŽ‹•p“x kn-keyword=ŽÎŽ‹•p“x en-keyword=‰Æ‘°—ð kn-keyword=‰Æ‘°—ð en-keyword=‘SƒQƒmƒ€ŠÖ˜A‰ðÍ kn-keyword=‘SƒQƒmƒ€ŠÖ˜A‰ðÍ en-keyword=˜A½‰ðÍ kn-keyword=˜A½‰ðÍ END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=4 article-no= start-page=201045 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202512 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Collagen depletion by pirfenidone enhances antitumor effect of oncolytic adenovirus against peritoneal metastases of gastric cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cancer-associated fibroblasts (CAFs) play a crucial role in collagen accumulation, which develops and promotes peritoneal metastasis (PM) in gastric cancer (GC). In addition, the abundant stromal collagens in the tumor microenvironment function as a physical barrier against penetration of antitumor drugs and oncolytic viruses. This study investigated whether collagen depletion by pirfenidone (PFD), an antifibrotic drug, enhances the antitumor effects of oncolytic adenoviruses. Analysis of the clinical samples revealed a significant association of high expression of collagen 1 and ƒ¿-smooth muscle actin (ƒ¿-SMA) with PM development and poor prognosis of advanced GC. Human and murine GC cells enhanced collagen production by fibroblasts, which was suppressed by PFD. Abundant fibroblasts and collagen inhibited the penetration of OBP-702, which reduced the antitumor effects of OBP-702 in the spheroid model. Intraperitoneal co-injection of GC cells and fibroblasts promoted the development of collagen-rich PM and reduced the antitumor effects of OBP-702 in vivo model. PFD suppressed collagen production in PM and improved viral penetration into the tumors, which enhanced the antitumor effects of OBP-702 against PM of GC. Collagen depletion by PFD enhances the penetration of OBP-702 into PM of GC, in turn enhancing the antitumor effects of OBP-702 against PM of GC. en-copyright= kn-copyright= en-aut-name=OkuraTomohiro en-aut-sei=Okura en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KikuchiSatoru en-aut-sei=Kikuchi en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TazawaHiroshi en-aut-sei=Tazawa en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MikaneYu en-aut-sei=Mikane en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KanayaNobuhiko en-aut-sei=Kanaya en-aut-mei=Nobuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MitsuiEma en-aut-sei=Mitsui en-aut-mei=Ema kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=UneYuta en-aut-sei=Une en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShigeyasuKunitoshi en-aut-sei=Shigeyasu en-aut-mei=Kunitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OharaToshiaki en-aut-sei=Ohara en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KurodaShinji en-aut-sei=Kuroda en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=NomaKazuhiro en-aut-sei=Noma en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=OhtsukaJunko en-aut-sei=Ohtsuka en-aut-mei=Junko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=OhkiRieko en-aut-sei=Ohki en-aut-mei=Rieko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KagawaShunsuke en-aut-sei=Kagawa en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=UrataYasuo en-aut-sei=Urata en-aut-mei=Yasuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Laboratory of Fundamental Oncology, National Cancer Center Research Institute kn-affil= affil-num=13 en-affil=Laboratory of Fundamental Oncology, National Cancer Center Research Institute kn-affil= affil-num=14 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil= Oncolys BioPharma, Inc. kn-affil= affil-num=16 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=MT: Regular Issue kn-keyword=MT: Regular Issue en-keyword=oncolytic virotherapy kn-keyword=oncolytic virotherapy en-keyword=peritoneal metastasis kn-keyword=peritoneal metastasis en-keyword=gastric cancer kn-keyword=gastric cancer en-keyword=collagen kn-keyword=collagen en-keyword=pirfenidone kn-keyword=pirfenidone END start-ver=1.4 cd-journal=joma no-vol=178 cd-vols= no-issue=1 article-no= start-page=e70775 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Reactive Carbonyl Species Mediate Isothiocyanate Signaling Pathway in Arabidopsis thaliana Guard Cells en-subtitle= kn-subtitle= en-abstract= kn-abstract=Our previous results demonstrated that depletion of glutathione (GSH) rather than elevation of levels of reactive oxygen species (ROS) is highly correlated with the decrease in stomatal aperture induced by isothiocyanates (ITCs), although ROS is considered a key second messenger in stomatal closure, suggesting that another signal component regulates stomatal apertures along with GSH depletion. This study, using Arabidopsis, clarified that reactive carbonyl species (RCS), especially acrolein and 4-hydroxy-(E)-2-nonenal, are determinants of stomatal aperture responses to ITCs. All tested ITCs, allyl isothiocyanate (AITC), sulforaphane (SFN), benzyl isothiocyanate (BITC), and phenethyl isothiocyanate (PEITC), significantly induced stomatal closure, which was inhibited by the RCS scavengers, carnosine and pyridoxamine. The RCS scavengers suppressed ITC-induced depletion of GSH but not elevation of ROS levels. All tested ITCs (AITC, SFN, BITC, and PEITC) increased levels of RCS and non-RCS aldehydes in the epidermal tissues. However, acrolein, 4-hydroxy-(E)-2-nonenal, crotonaldehyde, and (E)-2-pentenal induced stomatal closure at 10 and 100?ƒÊM, whereas propionaldehyde, butyraldehyde, and n-pentanal did not at concentrations up to 100?ƒÊM. Acrolein and 4-hydroxy-(E)-2-nonenal more effectively induced stomatal closure and GSH depletion than crotonaldehyde and (E)-2-pentenal did. The contents of RCS were more strongly correlated with GSH levels and stomatal closure than with ROS levels. These results suggest that RCS, especially acrolein and 4-hydroxy-(E)-2-nonenal, acts as key regulators of stomatal closure in guard cells in response to ITCs. en-copyright= kn-copyright= en-aut-name=FarzanaSumaiya en-aut-sei=Farzana en-aut-mei=Sumaiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IslamMd. Moshiul en-aut-sei=Islam en-aut-mei=Md. Moshiul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakamuraToshiyuki en-aut-sei=Nakamura en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakamuraYoshimasa en-aut-sei=Nakamura en-aut-mei=Yoshimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MunemasaShintaro en-aut-sei=Munemasa en-aut-mei=Shintaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ManoJun'ichi en-aut-sei=Mano en-aut-mei=Jun'ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MurataYoshiyuki en-aut-sei=Murata en-aut-mei=Yoshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=6 en-affil=Science Research Center, Yamaguchi University kn-affil= affil-num=7 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= en-keyword=arabidopsis kn-keyword=arabidopsis en-keyword=GSH depletion kn-keyword=GSH depletion en-keyword=isothiocyanate kn-keyword=isothiocyanate en-keyword=reactive carbonyl species kn-keyword=reactive carbonyl species en-keyword=reactive oxygen species kn-keyword=reactive oxygen species END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=12 article-no= start-page=5742 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250615 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Specific Heat-Killed Lactic Acid Bacteria Enhance Mucosal Aminopeptidase N Activity in the Small Intestine of Aged Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Aminopeptidase N (APN), an enzyme expressed in the small intestinal mucosa, is involved in dietary protein digestion. Previous studies have shown that oral administration of fermented milk containing lactic acid bacteria (LAB) enhances mucosal APN activity in young mice. This study aimed to investigate whether LAB strains stimulate mucosal APN activity in aged mice and to evaluate its relevance to age-related changes in body composition. The underlying molecular mechanisms were also explored in vitro. Experiment 1: Aged C57BL/6J mice were fed diets supplemented with heat-killed LAB strains?Enterococcus faecalis OU-23 (EF), Leuconostoc mesenteroides OU-03 (LM), or Lactiplantibacillus plantarum SNK12 (LP). Compared to the aged Control group, the ileal APN activity was significantly higher in the LP group. LP administration also elevated serum Gla-osteocalcin levels and decreased serum CTX-1 levels. Experiment 2: IEC-6 cells were co-cultured with LP that had been treated with RNase, DNase, or lysozyme. APN activity was significantly lower in cells co-cultured with DNase- or lysozyme-treated LP compared to those co-cultured with untreated LP. A specific LAB strain may enhance mucosal APN activity in the aged intestine, potentially contributing to improved bone metabolism. This effect may be mediated by bacterial DNA and peptidoglycan. en-copyright= kn-copyright= en-aut-name=TsurutaTakeshi en-aut-sei=Tsuruta en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WakisakaMami en-aut-sei=Wakisaka en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WatanabeTakumi en-aut-sei=Watanabe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NishijimaAoi en-aut-sei=Nishijima en-aut-mei=Aoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IkedaAkihito en-aut-sei=Ikeda en-aut-mei=Akihito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TeraokaMao en-aut-sei=Teraoka en-aut-mei=Mao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WangTianyang en-aut-sei=Wang en-aut-mei=Tianyang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ChenKuiyi en-aut-sei=Chen en-aut-mei=Kuiyi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NishinoNaoki en-aut-sei=Nishino en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Bio-Lab Co., Ltd. kn-affil= affil-num=4 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=7 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=8 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=9 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=aging kn-keyword=aging en-keyword=aminopeptidase N kn-keyword=aminopeptidase N en-keyword=bone metabolism kn-keyword=bone metabolism en-keyword=lactic acid bacteria kn-keyword=lactic acid bacteria en-keyword=small intestine kn-keyword=small intestine END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=245 end-page=260 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development and Evaluation of the Reliability and Validity of a Japanese Version of the Passive Aggression Scale kn-title=“ú–{Œê”Å The Passive Aggression Scale‚Ì쬂¨‚æ‚ÑM—Š«‚ƑÓ–«‚ÌŒŸ“¢ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SHIGETOUAyaka en-aut-sei=SHIGETOU en-aut-mei=Ayaka kn-aut-name=d“¡Ê‰¾ kn-aut-sei=d“¡ kn-aut-mei=ʉ¾ aut-affil-num=1 ORCID= en-aut-name=LimYoung-Ok en-aut-sei=Lim en-aut-mei=Young-Ok kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuhKyung-Hyun en-aut-sei=Suh en-aut-mei=Kyung-Hyun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SUMIOKAKyoko en-aut-sei=SUMIOKA en-aut-mei=Kyoko kn-aut-name=Z‰ª‹±Žq kn-aut-sei=Z‰ª kn-aut-mei=‹±Žq aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È affil-num=2 en-affil= kn-affil=Department of Counseling Psychology, Sahmyook University affil-num=3 en-affil= kn-affil=Department of Counseling Psychology, Sahmyook University affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=187 end-page=204 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Hortative Sentences in Japanese Seen from the Collocation of "jaa" ? Focusing on Discourse Structure ? kn-title=u‚¶‚á‚ v‚Æ‚Ì‹¤‹N‚©‚猩‚½“ú–{Œê‚ÌŠ©—U•¶\ ’k˜b\‘¢‚É’…–Ú‚µ‚Ä \ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=XINGLizhong en-aut-sei=XING en-aut-mei=Lizhong kn-aut-name=?—§’† kn-aut-sei=? kn-aut-mei=—§’† aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=169 end-page=185 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Others Who Bear Science: An Analysis of Kinship and Mirror Representations in Late Qing Science Fiction kn-title=‰ÈŠw‚ð’S‚¤‘¼ŽÒ‚½‚¿F´––‰ÈŠw¬à‚É‚¨‚¯‚ée‰‚Æ‹¾‘œ‚Ì•\Û•ªÍ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WUXIAOXUAN en-aut-sei=WU en-aut-mei=XIAOXUAN kn-aut-name=•¬Šž kn-aut-sei=• kn-aut-mei=¬Šž aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=109 end-page=128 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Career Development and the Meaning of Japanese Language Learning for Foreign Technical Intern Trainees: Narratives of Vietnamese Trainees Continuing Their Careers in Japan kn-title=ŠO‘l‹Z”\ŽÀK¶‚̃LƒƒƒŠƒAŒ`¬‚Æ“ú–{ŒêŠwK‚̈Ӗ¡•t‚¯\ “ú–{‚ŃLƒƒƒŠƒA‚ðŒp‘±‚·‚éƒxƒgƒiƒ€l‹Z”\ŽÀK¶‚ÌŒê‚è‚©‚ç \ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HOANGNgoc Bich Tran en-aut-sei=HOANG en-aut-mei=Ngoc Bich Tran kn-aut-name=ƒzƒAƒ“ƒSƒbƒN ƒrƒbƒNƒ`ƒƒƒ“ kn-aut-sei=ƒzƒAƒ“ƒSƒbƒN ƒrƒbƒNƒ`ƒƒƒ“ kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=89 end-page=107 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Filler Usage of 'De' in Modern Japanese Conversation kn-title=Œ»‘ã“ú–{Œê‚̉ï˜b‚É‚¨‚¯‚éu‚Åv‚̃tƒBƒ‰[“I‚ÈŽg—p‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=LIUYANG en-aut-sei=LIU en-aut-mei=YANG kn-aut-name=—«—m kn-aut-sei=—« kn-aut-mei=—m aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=71 end-page=88 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On Tough Sentences with the Agent of the Action as the Subject kn-title=“®ì‚ÌŽå‘Ì‚ðŽåŒê‚Æ‚·‚é“ïˆÕ•¶‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SUNHUIXIN en-aut-sei=SUN en-aut-mei=HUIXIN kn-aut-name=‘·Œd? kn-aut-sei=‘· kn-aut-mei=Œd? aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=31 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Leibniz on Human beings from his Table of Definitions kn-title=ƒ‰ƒCƒvƒjƒbƒc‚ÌulŠÔŠwv\w’è‹`Wx‚Ì–q‚ð’†S‚É\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MATSUDATsuyoshi en-aut-sei=MATSUDA en-aut-mei=Tsuyoshi kn-aut-name=¼“c‹B kn-aut-sei=¼“c kn-aut-mei=‹B aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=1 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Descriptions and Materials on the Local Government Histories of Okayama and Hiroshima prefectures kn-title=‘å“cA‚Ì•ª•z‚ÆŽí—Þ‚ÉŠÖ‚·‚錟“¢i3j\‰ªŽRŒ§EL“‡Œ§‚ÌŽ©Ž¡‘ÌŽj“™‚É‚¨‚¯‚é‹LqEŽ‘—¿\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TAKANOHiroshi en-aut-sei=TAKANO en-aut-mei=Hiroshi kn-aut-name=ûü–ìG kn-aut-sei=ûü–ì kn-aut-mei=G aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=6 article-no= start-page=e2518136123 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260204 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A nuclear CobW/WW-domain factor represses the CO2-concentrating mechanism in the green alga Chlamydomonas reinhardtii en-subtitle= kn-subtitle= en-abstract= kn-abstract=Microalgae induce a CO2-concentrating mechanism (CCM) to maintain photosynthesis when CO2 is limited. Because this system consumes a substantial portion of photosynthetically generated ATP, its suppression when CO2 levels rise is critical for energy balance, yet the underlying mechanism remains unclear. Here, we identify a nuclear repressor of the CCM in the green alga Chlamydomonas reinhardtii. A pull-down screen for interacting partners of the master activator CCM1/CIA5 revealed an uncharacterized protein that tightly associates with CCM1. This protein, CCM1-binding protein 1 (CBP1), combines a CobW/CobW_C GTP-binding metallochaperone module with a WW-domain characteristic of protein?protein interactions. CBP1 colocalizes and interacts with CCM1 in the nucleus regardless of CO2 conditions. Disruption of CBP1 does not affect growth or CCM induction under CO2 limitation but derepresses 27 of 41 CCM1-dependent low-CO2 inducible genes under high-CO2 conditions. These include the periplasmic and intracellular carbonic anhydrases (CAH1 and LCIB) and inorganic carbon transporters/channels (LCIA, LCI1, BST1, and BST3). Consistently, cbp1 mutants accumulate CAH1 and LCIB proteins and exhibit 40% higher inorganic carbon affinity under high-CO2 conditions; this phenotype is rescued by CBP1 complementation or by acetazolamide treatment. Crucially, cbp1 mutants exhibit significant growth delays under high-CO2 conditions, especially when light is limiting, providing direct evidence that CBP1-mediated repression is essential for energy conservation. Thus, CBP1 prevents unnecessary CCM activity when CO2 is abundant, acting upstream of both transporter/channel and carbonic anhydrase modules. Our findings suggest a regulatory mechanism potentially linking zinc-dependent protein chemistry to CCM gene repression, providing insights into energy-efficient CO2 sensing in aquatic photosynthetic organisms. en-copyright= kn-copyright= en-aut-name=ShimamuraDaisuke en-aut-sei=Shimamura en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YasudaJunko en-aut-sei=Yasuda en-aut-mei=Junko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamaharaYosuke en-aut-sei=Yamahara en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakanoHirobumi en-aut-sei=Nakano en-aut-mei=Hirobumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OzawaShin-Ichiro en-aut-sei=Ozawa en-aut-mei=Shin-Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TokutsuRyutaro en-aut-sei=Tokutsu en-aut-mei=Ryutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamagamiAyumi en-aut-sei=Yamagami en-aut-mei=Ayumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MatsushitaTomonao en-aut-sei=Matsushita en-aut-mei=Tomonao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TakahashiYuichiro en-aut-sei=Takahashi en-aut-mei=Yuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NakanoTakeshi en-aut-sei=Nakano en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FukuzawaHideya en-aut-sei=Fukuzawa en-aut-mei=Hideya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YamanoTakashi en-aut-sei=Yamano en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Graduate School of Biostudies, Division of Integrated Life Science, Kyoto University kn-affil= affil-num=2 en-affil=Graduate School of Biostudies, Division of Integrated Life Science, Kyoto University kn-affil= affil-num=3 en-affil=Graduate School of Biostudies, Division of Integrated Life Science, Kyoto University kn-affil= affil-num=4 en-affil=Graduate School of Biostudies, Division of Integrated Life Science, Kyoto University kn-affil= affil-num=5 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Science, Division of Biological Sciences, Kyoto University kn-affil= affil-num=7 en-affil=Graduate School of Biostudies, Division of Integrated Life Science, Kyoto University kn-affil= affil-num=8 en-affil=Graduate School of Science, Division of Biological Sciences, Kyoto University kn-affil= affil-num=9 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=10 en-affil=Graduate School of Biostudies, Division of Integrated Life Science, Kyoto University kn-affil= affil-num=11 en-affil=Graduate School of Biostudies, Division of Integrated Life Science, Kyoto University kn-affil= affil-num=12 en-affil=Graduate School of Biostudies, Division of Integrated Life Science, Kyoto University kn-affil= en-keyword=carbonic anhydrase kn-keyword=carbonic anhydrase en-keyword=Chlamydomonas reinhardtii kn-keyword=Chlamydomonas reinhardtii en-keyword=CO2-concentrating mechanism kn-keyword=CO2-concentrating mechanism en-keyword=photosynthesis kn-keyword=photosynthesis en-keyword=pyrenoid kn-keyword=pyrenoid END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=3 article-no= start-page=369 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260123 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Impact of the July 2018 Heavy Rain Disaster on the Endangered Nagoya Daruma Pond Frog (Pelophylax porosus brevipodus) in Rice Fields of Mabi Town, Kurashiki City, Western Japan: Changes in Population Structure over Five Years en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rice paddy fields (referred to below as rice fields) are important not only for food production, but also as habitats for various species. The Nagoya Daruma Pond Frog (Pelophylax porosus brevipodus) is an endangered frog species endemic to Japan, mainly living in and around rice field areas. In July 2018, heavy rainfall caused severe flooding in Mabi Town of Okayama Prefecture, western Japan, submerging numerous rice fields and affecting local frog populations, including P. porosus brevipodus. To clarify whether the population structure of P. porosus brevipodus changed following the flood disaster in the rice fields of Mabi Town, we conducted quantitative field surveys in a rice fallow field in mid-October before (2017) and after (2018, 2020?2022, excluding 2019) the flood. The number of frogs declined sharply after the 2018 flood, reaching only a few individuals by 2020, but showed a substantial recovery in 2021 following the resumption of rice cultivation, although numbers decreased again in 2022. This recovery, despite fluctuations, indicates that habitat restoration through rice farming played a key role in enabling the population to rebound. Our findings underscore the importance of maintaining and restoring rice field environments after natural disasters for the survival and long-term recovery of P. porosus brevipodus. en-copyright= kn-copyright= en-aut-name=NakajimaRyo en-aut-sei=Nakajima en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AzumiDaisuke en-aut-sei=Azumi en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TadaMasakazu en-aut-sei=Tada en-aut-mei=Masakazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakaichiJunya en-aut-sei=Nakaichi en-aut-mei=Junya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KatsuharaKoki R. en-aut-sei=Katsuhara en-aut-mei=Koki R. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakataKazuyoshi en-aut-sei=Nakata en-aut-mei=Kazuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Okayama Prefectural Public Interest Incorporated Foundation for Environmental Conservation kn-affil= affil-num=4 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=agroecosystem kn-keyword=agroecosystem en-keyword=conservation ecology kn-keyword=conservation ecology en-keyword=endangered amphibian kn-keyword=endangered amphibian en-keyword=paddy field kn-keyword=paddy field en-keyword=post-disaster habitat recovery kn-keyword=post-disaster habitat recovery END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=1 article-no= start-page=116781 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Immunopeptidomics combined with full-length transcriptomics uncovers diverse neoantigens en-subtitle= kn-subtitle= en-abstract= kn-abstract=Neoantigens are crucial for antitumor immunity and immune checkpoint inhibitor (ICI) efficacy by triggering strong immune responses. However, conventional methods for identifying neoantigens, such as whole-exon sequencing and short-read RNA sequencing (RNA-seq), appear to be insufficient, and the tumor mutational burden cannot sufficiently predict ICI efficacy. In this study, we employed a proteogenomic approach using long-read RNA-seq with Pacific Biosciences Single-Molecule Real-Time Sequencing technology to analyze full-length transcripts in combination with the human leukocyte antigen ligandome. As a result, many neoantigen candidates were identified, which were unregistered in a comprehensive database, including those from non-coding regions. Additionally, we validated the responses of specific T cell receptors (TCRs) to these candidates and identified several pairs of TCRs and neoantigens. These findings highlight the presence of more diverse neoantigens than expected that cannot be identified by conventional methods. en-copyright= kn-copyright= en-aut-name=IshinoTakamasa en-aut-sei=Ishino en-aut-mei=Takamasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WatanabeTomofumi en-aut-sei=Watanabe en-aut-mei=Tomofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TokitaSerina en-aut-sei=Tokita en-aut-mei=Serina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UedaYouki en-aut-sei=Ueda en-aut-mei=Youki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KawaseKatsushige en-aut-sei=Kawase en-aut-mei=Katsushige kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakanoYuka en-aut-sei=Takano en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ThuYin Min en-aut-sei=Thu en-aut-mei=Yin Min kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SuzukiYuta en-aut-sei=Suzuki en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OwaChie en-aut-sei=Owa en-aut-mei=Chie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=InozumeTakashi en-aut-sei=Inozume en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=ZhouWenhao en-aut-sei=Zhou en-aut-mei=Wenhao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NagasakiJoji en-aut-sei=Nagasaki en-aut-mei=Joji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KochinVitaly en-aut-sei=Kochin en-aut-mei=Vitaly kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=UenoToshihide en-aut-sei=Ueno en-aut-mei=Toshihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=KojimaShinya en-aut-sei=Kojima en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=Honobe-TabuchiAkiko en-aut-sei=Honobe-Tabuchi en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=KawamuraTatsuyoshi en-aut-sei=Kawamura en-aut-mei=Tatsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=OhnumaTakehiro en-aut-sei=Ohnuma en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=MatsuzawaTakamitsu en-aut-sei=Matsuzawa en-aut-mei=Takamitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=KawaharaYu en-aut-sei=Kawahara en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=YamashitaKazuo en-aut-sei=Yamashita en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=LinJason en-aut-sei=Lin en-aut-mei=Jason kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=KosekiJun en-aut-sei=Koseki en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=NishikawaHiroyoshi en-aut-sei=Nishikawa en-aut-mei=Hiroyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= en-aut-name=KatoNaoya en-aut-sei=Kato en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=26 ORCID= en-aut-name=ShimamuraTeppei en-aut-sei=Shimamura en-aut-mei=Teppei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=27 ORCID= en-aut-name=MorishitaShinichi en-aut-sei=Morishita en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=28 ORCID= en-aut-name=SuzukiYutaka en-aut-sei=Suzuki en-aut-mei=Yutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=29 ORCID= en-aut-name=ManoHiroyuki en-aut-sei=Mano en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=30 ORCID= en-aut-name=TorigoeToshihiko en-aut-sei=Torigoe en-aut-mei=Toshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=31 ORCID= en-aut-name=KanasekiTakayuki en-aut-sei=Kanaseki en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=32 ORCID= en-aut-name=KawazuMasahito en-aut-sei=Kawazu en-aut-mei=Masahito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=33 ORCID= en-aut-name=TogashiYosuke en-aut-sei=Togashi en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=34 ORCID= affil-num=1 en-affil=Department of Tumor Microenvironment, Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Tumor Microenvironment, Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Division of Cancer Immunology, Graduate School of Medical and Dental Sciences, Niigata University kn-affil= affil-num=4 en-affil=Department of Tumor Microenvironment, Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute kn-affil= affil-num=6 en-affil=Department of Tumor Microenvironment, Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Tumor Microenvironment, Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Computational Biology and Medical Sciences, The University of Tokyo kn-affil= affil-num=9 en-affil=Department of Computational Biology and Medical Sciences, The University of Tokyo kn-affil= affil-num=10 en-affil=Department of Dermatology, Chiba University Graduate School of Medicine kn-affil= affil-num=11 en-affil=Department of Tumor Microenvironment, Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Tumor Microenvironment, Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Immunology, Nagoya University Graduate School of Medicine kn-affil= affil-num=14 en-affil=Division of Cellular Signaling, National Cancer Center Research Institute kn-affil= affil-num=15 en-affil=Division of Cellular Signaling, National Cancer Center Research Institute kn-affil= affil-num=16 en-affil=Department of Dermatology, University of Yamanashi kn-affil= affil-num=17 en-affil=Department of Dermatology, University of Yamanashi kn-affil= affil-num=18 en-affil=Department of Dermatology, Kumamoto Kenhoku Hospital kn-affil= affil-num=19 en-affil=Department of Dermatology, Chiba University Graduate School of Medicine kn-affil= affil-num=20 en-affil=Department of Dermatology, Chiba University Graduate School of Medicine kn-affil= affil-num=21 en-affil=KOTAI Biotechnologies, Inc kn-affil= affil-num=22 en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute kn-affil= affil-num=23 en-affil=Division of Systems Biology, Nagoya University Graduate School of Medicine kn-affil= affil-num=24 en-affil=Department of Immunology, Nagoya University Graduate School of Medicine kn-affil= affil-num=25 en-affil=Department of Urology, Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=26 en-affil=Department of Gastroenterology, Graduate School of Medicine, Chiba University kn-affil= affil-num=27 en-affil=Division of Systems Biology, Nagoya University Graduate School of Medicine kn-affil= affil-num=28 en-affil=Department of Computational Biology and Medical Sciences, The University of Tokyo kn-affil= affil-num=29 en-affil=Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo kn-affil= affil-num=30 en-affil=Division of Cellular Signaling, National Cancer Center Research Institute kn-affil= affil-num=31 en-affil= kn-affil= affil-num=32 en-affil=Division of Cancer Immunology, Graduate School of Medical and Dental Sciences, Niigata University kn-affil= affil-num=33 en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute kn-affil= affil-num=34 en-affil=Department of Tumor Microenvironment, Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=cancer immunology kn-keyword=cancer immunology en-keyword=neoantigen kn-keyword=neoantigen en-keyword=long-read RNA sequencing kn-keyword=long-read RNA sequencing en-keyword=HLA ligandome kn-keyword=HLA ligandome en-keyword=single-cell RNA sequencing kn-keyword=single-cell RNA sequencing en-keyword=single-cell TCR sequencing kn-keyword=single-cell TCR sequencing en-keyword=exhausted T cell kn-keyword=exhausted T cell END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=2 article-no= start-page=E82 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Crystal structure of tris[4-(3,4-dimethoxythiophen-2-yl)phenyl]amine en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the title compound tris?[4-(3,4-di?meth?oxy?thio?phen-2-yl)phen?yl]amine (DMOT-TPA), C36H33NO6S3, the central nitro?gen atom shows no pyramidalization, with the three para-phenyl?ene rings arranged in a propeller-like geometry. Each thio?phene ring is twisted by about 25?29‹ relative to the adjacent phenyl?ene ring, giving a distorted ƒÎ-conjugated framework. In the crystal, mol?ecules are linked through multiple C?H?ƒÎ inter?actions into two-dimensional sheets, which extend into a three-dimensional network. A Cambridge Structural Database survey revealed no prior examples of tri?phenyl?amines bearing 3,4-di?meth?oxy?thio?phen units at the para positions. This unique structure provides new insights into the design of redox-active organic materials. en-copyright= kn-copyright= en-aut-name=YanoMasafumi en-aut-sei=Yano en-aut-mei=Masafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KashiwagiYukiyasu en-aut-sei=Kashiwagi en-aut-mei=Yukiyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OishiKoki en-aut-sei=Oishi en-aut-mei=Koki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YanoMinori en-aut-sei=Yano en-aut-mei=Minori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MitsudoKoichi en-aut-sei=Mitsudo en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Kansai University kn-affil= affil-num=2 en-affil=Osaka Research Institute of Industrial Science and Technology kn-affil= affil-num=3 en-affil=Kansai University kn-affil= affil-num=4 en-affil=Kansai University kn-affil= affil-num=5 en-affil=Okayama University kn-affil= en-keyword=crystal structure kn-keyword=crystal structure en-keyword=infrared absorption dye kn-keyword=infrared absorption dye en-keyword=one-electron oxidation kn-keyword=one-electron oxidation END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251117 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Daytime Bladder Control Status in Toddlerhood Is Associated With Subsequent Bedwetting in Preschool Years: A Nationwide Cohort Study of Over 30?000 Japanese Children en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objectives: Nocturnal enuresis is common in early childhood. While daytime bladder control typically precedes nighttime continence, the temporal relationship between early daytime bladder control and subsequent bedwetting remains unclear. We investigated whether daytime bladder control status at age 2.5?years?as indicated by diaper use?is associated with bedwetting at age 4.5?years in a Japanese nationwide cohort.
Methods: We analyzed data from the Japanese Longitudinal Survey of Newborns in the 21st Century (2010 cohort). Daytime bladder control was assessed at age 2.5?years through caregiver-reported diaper use, and bedwetting frequency at age 4.5?years through parental questionnaires. Modified Poisson regression estimated risk ratios (RRs), adjusting for birth-related factors, socioeconomic status, daycare attendance, and developmental milestones.
Results: Among 32?168 children, 26?651 (82.8%) still used diapers at 2.5?years. Bedwetting prevalence at 4.5?years was 42.2%: 34.5% in children who achieved daytime bladder control at 2.5?years versus 43.9% in those still using diapers. After multivariable adjustment, incomplete daytime bladder control at 2.5?years was associated with higher bedwetting risk (adjusted RR 1.25; 95% CI, 1.20?1.31). Multinomial regression revealed dose?response relationships: odds ratios 1.41 (95% CI, 1.30?1.52) for gsometimesh and 1.58 (95% CI, 1.42?1.77) for goftenh bedwetting.
Conclusions: Daytime bladder control status at 2.5?years was associated with a 25% increased bedwetting risk at 4.5?years. This association likely reflects individual differences in bladder control maturation rather than causal effects. While daytime bladder control may serve as a developmental marker, its validity as an intervention target remains unestablished. en-copyright= kn-copyright= en-aut-name=MoriwakeTakatoshi en-aut-sei=Moriwake en-aut-mei=Takatoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoNaomi en-aut-sei=Matsumoto en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TominagaYusuke en-aut-sei=Tominaga en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UraguchiKensuke en-aut-sei=Uraguchi en-aut-mei=Kensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KobayashiTomoko en-aut-sei=Kobayashi en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TsuboiIchiro en-aut-sei=Tsuboi en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YoshinagaKasumi en-aut-sei=Yoshinaga en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamanoiTomoaki en-aut-sei=Yamanoi en-aut-mei=Tomoaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KawadaTatsushi en-aut-sei=Kawada en-aut-mei=Tatsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=SadahiraTakuya en-aut-sei=Sadahira en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KatayamaSatoshi en-aut-sei=Katayama en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=IwataTakehiro en-aut-sei=Iwata en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NishimuraShingo en-aut-sei=Nishimura en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=BekkuKensuke en-aut-sei=Bekku en-aut-mei=Kensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=EdamuraKohei en-aut-sei=Edamura en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=TakaoSoshi en-aut-sei=Takao en-aut-mei=Soshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= affil-num=1 en-affil=Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Urology Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Okayama Japan kn-affil= affil-num=10 en-affil=Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=15 en-affil=Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=16 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=17 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=18 en-affil=Department of Urology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=bedwetting kn-keyword=bedwetting en-keyword=cohort study kn-keyword=cohort study en-keyword=daytime bladder control kn-keyword=daytime bladder control en-keyword=nocturnal enuresis kn-keyword=nocturnal enuresis END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=376 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Oral Health-Related Quality of Life and Self-Reported Oral Health Status Are Associated with Change in Self-Reported Depression Status: A Cohort Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background/Objectives: Oral health-related quality of life (OHRQoL) may influence mental health outcomes, yet longitudinal evidence on its association with depression remains limited. This study aimed to examine whether oral health status and OHRQoL are associated with a change in self-reported depression status among adults in Japan. Methods: We analyzed data from the Japan COVID-19 and Society Internet Survey (JACSIS), conducted in 2022 and 2023. A total of 15,068 participants aged ?20 years without depression at baseline were included. Depression status was identified by self-reported measures between the two survey waves. Logistic regression models estimated odds ratios (ORs) and 95% confidence intervals (CIs) for change in self-reported depression status in relation to OHRQoL and oral health status, adjusting for sociodemographic and behavioral factors. Results: During follow-up, 218 participants (1.45%) reported a change in self-reported depression status. Poorer OHRQoL was significantly associated with a change in self-reported depression status (OR: 1.018; 95% CI: 1.001?1.036; p = 0.039). Additional risk factors included younger age (OR: 0.974; 95% CI: 0.964?0.985), participation in hobbies and cultural activities (OR: 2.224; 95% CI: 1.498?3.302), habitual use of sleeping pills or anxiolytics (current use OR: 3.512; 95% CI: 2.267?5.442), increased loneliness (OR: 1.217; 95% CI: 1.140?1.299), lower life satisfaction (OR: 0.900; 95% CI: 0.836?0.969), and poor self-rated health (OR: 2.921; 95% CI: 1.810?4.715). Conclusions: Impaired OHRQoL was associated with a change in self-reported depression status, potentially through psychosocial mechanisms. These findings suggest that oral health and OHRQoL may be relevant factors to consider in integrated oral and mental health approaches in clinical practice. en-copyright= kn-copyright= en-aut-name=TakeuchiNoriko en-aut-sei=Takeuchi en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MaruyamaTakayuki en-aut-sei=Maruyama en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ToyamaNaoki en-aut-sei=Toyama en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KatsubeYuzuki en-aut-sei=Katsube en-aut-mei=Yuzuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TabuchiTakahiro en-aut-sei=Tabuchi en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=EkuniDaisuke en-aut-sei=Ekuni en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Preventive Dentistry, Division of Dentistry, Medical Development Field, Okayama University kn-affil= affil-num=2 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Dental School, Okayama University kn-affil= affil-num=5 en-affil=Division of Epidemiology, School of Public Health, Tohoku University Graduate School of Medicine kn-affil= affil-num=6 en-affil=Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=oral health-related quality of life kn-keyword=oral health-related quality of life en-keyword=depression status kn-keyword=depression status en-keyword=cohort study kn-keyword=cohort study END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue=5 article-no= start-page=e70094 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202510 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Seaweed Extracts Improve Salinity Tolerance in Cereal Crops?A Meta]Analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Seaweeds are considered an essential component of the blue economy. Because seaweed extracts are rich in bioactive compounds that enhance plant stress resilience, exploiting this resource could offer a sustainable solution for crop production. Salinity is a major abiotic challenge that significantly impacts crop yield and food security. Through meta-analysis, we explored whether the exogenous application of seaweed extracts improves the salt tolerance of cereal crops. All the studies chosen for this study utilized aqueous seaweed extracts as foliar sprays. A multi-level meta-analysis with a mixed effects model was performed to determine the effect size. This meta-analysis demonstrated that applying aqueous seaweed extracts enhanced the shoot and root biomass under normal and salinity stress conditions, suggesting that seaweed extract can help improve crop stress tolerance. The seaweeds studied belonged to three classes: Phaeophyceae, Rhodophyta, and Chlorophyta, with extracts from Chlorophyta and Phaeophyceae significantly enhancing biomass production under salinity conditions. Applying aqueous seaweed extracts effectively improved salinity tolerance at both 34.2?100?mM and 101?400?mM NaCl equivalent salinity stress. Moreover, exogenous foliar application of ??25% aqueous seaweed extracts was most effective for improving salinity tolerance in cereals. The impact of seaweed extracts on cereal crop yields has not been extensively reported; therefore, further studies should focus on this aspect. en-copyright= kn-copyright= en-aut-name=NuruzzamanMd. en-aut-sei=Nuruzzaman en-aut-mei=Md. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=Tahjib]Ul]ArifMd. en-aut-sei=Tahjib]Ul]Arif en-aut-mei=Md. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HannanMd. Abdul en-aut-sei=Hannan en-aut-mei=Md. Abdul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MurataYoshiyuki en-aut-sei=Murata en-aut-mei=Yoshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HossainM. Afzal en-aut-sei=Hossain en-aut-mei=M. Afzal kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Plant Resources, College of Industrial Sciences, Kongju National University kn-affil= affil-num=2 en-affil=Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University kn-affil= affil-num=3 en-affil=Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University kn-affil= affil-num=4 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University kn-affil= en-keyword=abiotic stress kn-keyword=abiotic stress en-keyword=crop tolerance kn-keyword=crop tolerance en-keyword=marine algae kn-keyword=marine algae en-keyword=plant growth kn-keyword=plant growth en-keyword=salt stress kn-keyword=salt stress en-keyword=sustainable agriculture kn-keyword=sustainable agriculture END start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=3 article-no= start-page=118 end-page=125 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The results of COVID-19 antibody testing studies in Bizen, Japan kn-title=”õ‘OŽs‚É‚¨‚¯‚éVŒ^ƒRƒƒiƒEƒCƒ‹ƒXŠ´õÇ‚ÌR‘ÌŒŸ¸‚ÉŠÖ‚·‚錤‹†‚̬‰Ê•ñ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@We conducted two prospective cohort studies (June 2022?March 2023 and Nov 2023?Jan 2024) of 1,899 and 445 residents and other individuals who are affiliated with institutions in the city of Bizen in Japan's Okayama prefecture (population 32,320 as of 2020). We measured the subjects' titers of antibodies against SARS-CoV-2, evaluated changes in their antibody titers, and assessed the associations of the titers with the subjects' vaccination status, infection, and COVID-19 status/severity. This report summarizes the two studies' findings. These prospective studies based on a wide age range in a general population provide information that can be used to determine the appropriate timing of vaccination during a pandemic. en-copyright= kn-copyright= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name=—Š“¡‹MŽu kn-aut-sei=—Š“¡ kn-aut-mei=‹MŽu aut-affil-num=1 ORCID= en-aut-name=SasakiAyako en-aut-sei=Sasaki en-aut-mei=Ayako kn-aut-name=²X–؈»Žq kn-aut-sei=²X–Ø kn-aut-mei=ˆ»Žq aut-affil-num=2 ORCID= en-aut-name=MatsumotoNaomi en-aut-sei=Matsumoto en-aut-mei=Naomi kn-aut-name=¼–{®”ü kn-aut-sei=¼–{ kn-aut-mei=®”ü aut-affil-num=3 ORCID= en-aut-name=KadowakiTomoka en-aut-sei=Kadowaki en-aut-mei=Tomoka kn-aut-name=–å˜e’m‰Ô kn-aut-sei=–å˜e kn-aut-mei=’m‰Ô aut-affil-num=4 ORCID= en-aut-name=MitsuhashiToshiharu en-aut-sei=Mitsuhashi en-aut-mei=Toshiharu kn-aut-name=ŽO‹´—˜° kn-aut-sei=ŽO‹´ kn-aut-mei=—˜° aut-affil-num=5 ORCID= en-aut-name=TakaoSoshi en-aut-sei=Takao en-aut-mei=Soshi kn-aut-name=‚”ö‘Ži kn-aut-sei=‚”ö kn-aut-mei=‘Ži aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Science, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ˆãŽ•–òŠwˆæ@‰uŠwE‰q¶Šw affil-num=2 en-affil=Kurashiki City Public Health Center kn-affil=‘q•~Žs•ÛŒ’Š affil-num=3 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Science, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ˆãŽ•–òŠwˆæ@‰uŠwE‰q¶Šw affil-num=4 en-affil=Center for Public Health Action in Applied Epidemiology, National Institute of Infectious Diseases kn-affil=‘—§Š´õÇŒ¤‹†Š@‰ž—p‰uŠwŒ¤‹†ƒZƒ“ƒ^[ affil-num=5 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=6 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Science, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ˆãŽ•–òŠwˆæ@‰uŠwE‰q¶Šw en-keyword=COVID-19 kn-keyword=COVID-19 en-keyword=ƒƒNƒ`ƒ“ (vaccination) kn-keyword=ƒƒNƒ`ƒ“ (vaccination) en-keyword=R‘̉¿ (antibody titer) kn-keyword=R‘̉¿ (antibody titer) en-keyword=Š´õ (infection) kn-keyword=Š´õ (infection) END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3 article-no= start-page=168 end-page=178 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Polyphyletic domestication and inter-lineage hybridization magnified genetic diversity of cultivated melon, Cucumis melo L. en-subtitle= kn-subtitle= en-abstract= kn-abstract=Melon accessions with diverse geographical origins were classified into large and small seed-types by length of seed at the boundary of 9?mm, and into five populations based on polymorphisms in the nuclear genome. They were further divided into three maternal lineages, Ia, Ib, and Ic, by polymorphisms in the chloroplast genome. By combining these three classifications, the Europe/US subsp. melo and the East Asian subsp. agrestis were characterized as [large seed, Ib, PopA1 or A2] and [small seed, Ia, PopB1 or B2], respectively, indicating nearly perfect divergence. In South Asia, in addition to the Europe/US and East Asian types, recombinant types between the two types were detected and accounted for 34.8% of South Asian melon. The finding of such an intermixed structure of genetic variation supported the Indian origin of Ia and Ib types. As to Momordica popular in South Asia, seed length was intermediate between the large and small seed-types, and chloroplast type was a mixture of Ia and Ib, suggesting its origin from the recombinant type. In Africa, three lineages of melon were distributed allopatrically and showed distinct divergence. Subsp. agrestis of the Ic type proved to be endemic to Africa, indicating its African origin. en-copyright= kn-copyright= en-aut-name=TanakaKatsunori en-aut-sei=Tanaka en-aut-mei=Katsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShigitaGentaro en-aut-sei=Shigita en-aut-mei=Gentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=DungTran Phuong en-aut-sei=Dung en-aut-mei=Tran Phuong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NhiPhan Thi Phuong en-aut-sei=Nhi en-aut-mei=Phan Thi Phuong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakahashiMami en-aut-sei=Takahashi en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MondenYuki en-aut-sei=Monden en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NishidaHidetaka en-aut-sei=Nishida en-aut-mei=Hidetaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IshikawaRyuji en-aut-sei=Ishikawa en-aut-mei=Ryuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KatoKenji en-aut-sei=Kato en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Faculty of Agriculture and Life Science, Hirosaki University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=4 en-affil=University of Agriculture and Forestry, Hue University kn-affil= affil-num=5 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=8 en-affil=Faculty of Agriculture and Life Science, Hirosaki University kn-affil= affil-num=9 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=chloroplast genome kn-keyword=chloroplast genome en-keyword=Cucumis melo kn-keyword=Cucumis melo en-keyword=domestication kn-keyword=domestication en-keyword=genetic diversity kn-keyword=genetic diversity en-keyword=melon kn-keyword=melon en-keyword=molecular polymorphism kn-keyword=molecular polymorphism en-keyword=seed size kn-keyword=seed size END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=1 article-no= start-page=69 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=P53-Armed Oncolytic Virotherapy Promotes the Efficacy of PD1 Blockade in Murine Osteosarcoma Tumors en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background/Aim: Osteosarcoma (OS) is refractory to immune checkpoint inhibitors targeting programmed cell death 1 (PD1)/PD ligand 1 (PD-L1) due to poor immune response. We previously developed telomerase-specific, replication-competent oncolytic adenoviruses non-armed OBP-301 and P53-armed OBP-702 that exert antitumor efficacy against human OS cells. Recently, we demonstrated that P53-armed OBP-702 induces more profound immunogenic cell death and antitumor immune response against human and murine OS cells than does non-armed OBP-301. In the present study, we assessed the combined efficacy of PD1 blockade and P53-armed OBP-702 against murine OS cells.
Materials and Methods: Three murine OS cell lines (K7M2, NHOS, NHOS-LM4) were used to assess the cytopathic effect of non-armed OBP-301 and P53-armed OBP-702 by XTT assay. Virus-induced immunogenic cell death was assessed by analyzing the levels of extracellular adenosine triphosphate and high-mobility group box protein B1. The expression of PD-L1 and PD-L2 was analyzed by flow cytometry. The malignant potential of NHOS-LM4 cells was analyzed by a migration and invasion assay. An orthotopic NHOS-LM4 tumor model was used to evaluate the antitumor efficacy of combination therapy with P53-armed OBP-702 and anti-PD1.
Results: P53-armed OBP-702 exhibited antitumor potential for the induction of immunogenic cell death, apoptosis, autophagy, and PD-L1/2 upregulation in K7M2 and NHOS cells. NHOS-LM4 cells showed increased migratory and invasive ability compared to NHOS cells. P53-armed OBP-702 significantly suppressed the malignant potential of NHOS-LM4 cells. Combination dosing showed that P53-armed OBP-702 significantly promoted the antitumor effect of PD1 blockade against NHOS-LM4 tumors.
Conclusion: Our results suggest that P53-armed OBP-702 is a promising agent for improving the antitumor effect of PD1 blockade in treating invasive OS. en-copyright= kn-copyright= en-aut-name=KUREMIHO en-aut-sei=KURE en-aut-mei=MIHO kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TAZAWAHIROSHI en-aut-sei=TAZAWA en-aut-mei=HIROSHI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=DEMIYAKOJI en-aut-sei=DEMIYA en-aut-mei=KOJI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KONDOHIROYA en-aut-sei=KONDO en-aut-mei=HIROYA kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MOCHIZUKIYUSUKE en-aut-sei=MOCHIZUKI en-aut-mei=YUSUKE kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KOMATSUBARATADASHI en-aut-sei=KOMATSUBARA en-aut-mei=TADASHI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YOSHIDAAKI en-aut-sei=YOSHIDA en-aut-mei=AKI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=UOTANIKOJI en-aut-sei=UOTANI en-aut-mei=KOJI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HASEIJOE en-aut-sei=HASEI en-aut-mei=JOE kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=FUJIWARATOMOHIRO en-aut-sei=FUJIWARA en-aut-mei=TOMOHIRO kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KUNISADATOSHIYUKI en-aut-sei=KUNISADA en-aut-mei=TOSHIYUKI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=URATAYASUO en-aut-sei=URATA en-aut-mei=YASUO kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KAGAWASHUNSUKE en-aut-sei=KAGAWA en-aut-mei=SHUNSUKE kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=OZAKITOSHIFUMI en-aut-sei=OZAKI en-aut-mei=TOSHIFUMI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=FUJIWARATOSHIYOSHI en-aut-sei=FUJIWARA en-aut-mei=TOSHIYOSHI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=14 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Osteosarcoma kn-keyword=Osteosarcoma en-keyword=oncolytic adenovirus kn-keyword=oncolytic adenovirus en-keyword=P53 kn-keyword=P53 en-keyword=immunogenic cell death kn-keyword=immunogenic cell death en-keyword=PD1 kn-keyword=PD1 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251222 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Suppression of Na+ Uptake Via Apoplastic Flow by Chitosan in Rice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose: Chitosan enhances tolerance to salinity in rice. Apoplastic flow plays a crucial role in the accumulation of sodium (Na+) in rice under salinity. This study investigated the effects of exogenous chitosan on apoplastic flow and Na+ uptake in NaCl-treated rice seedlings. Methods: We employed an apoplastic tracer, trisodium salt of 8-hydroxy-1,3,6-pyrenetrisulphonic acid (PTS), in order to evaluate apoplastic flow in rice (Oryza sativa L., cv. Nipponbare) seedlings that were hydroponically grown in the solution containing NaCl (0 and 25 mM), and chitosan (0 mg L??1, 10 mg L??1, and 50 mg L??1). Results: Application of 25 mM NaCl significantly increased PTS uptake and Na+ content in shoots but did not affect K+ content, resulting in a lower K+/Na+ ratio although 25 mM NaCl did not affect the seedling growth. The application of chitosan suppressed Na+-enhanced PTS uptake and Na+ accumulation in shoots without affecting the K+ content, which led to a higher K+/Na+ ratio. Moreover, chitosan did not affect the reducing sugar content or electrical conductivity in the solution containing NaCl. Conclusions: These results suggest that application of chitosan suppressed Na+-enhanced apoplastic flow to reduce Na+ uptake in rice seedlings. en-copyright= kn-copyright= en-aut-name=ZhaoMaoxiang en-aut-sei=Zhao en-aut-mei=Maoxiang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=GalibMd. Asadulla Al en-aut-sei=Galib en-aut-mei=Md. Asadulla Al kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakamuraToshiyuki en-aut-sei=Nakamura en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakamuraYoshimasa en-aut-sei=Nakamura en-aut-mei=Yoshimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HiraiYoshihiko en-aut-sei=Hirai en-aut-mei=Yoshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakashimaYoshitaka en-aut-sei=Nakashima en-aut-mei=Yoshitaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MunemasaShintaro en-aut-sei=Munemasa en-aut-mei=Shintaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MoriIzumi C. en-aut-sei=Mori en-aut-mei=Izumi C. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MurataYoshiyuki en-aut-sei=Murata en-aut-mei=Yoshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=6 en-affil= kn-affil= affil-num=7 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=8 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=9 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= en-keyword=Rice ? Salinity kn-keyword=Rice ? Salinity en-keyword=Apoplastic flow kn-keyword=Apoplastic flow en-keyword=Trisodium-8-hydroxy-1,3,6-pyrenetrisulphonic acid kn-keyword=Trisodium-8-hydroxy-1,3,6-pyrenetrisulphonic acid en-keyword=Chitosan kn-keyword=Chitosan END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=11 article-no= start-page=e43440 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202506 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Suppression of defect in plated film on AMed metal products by electron beam polishing en-subtitle= kn-subtitle= en-abstract= kn-abstract=Additively manufactured (AMed) metal products with high shape accuracy can be produced by laser powder bed fusion (LPBF). However, the AMed metal products have large surface roughness due to the arrangement of bead shape. Surface irregularities such as spatter and small cavity are also generated on the surface. Furthermore, elemental composition of AMed metal products may be changed from that of original metal powder due to oxidation of surface. On the other hand, electroless plating has been applied to improvement of surface functions. However, defect is often generated in the plated film due to surface irregularities and oxidation of base material. Therefore, surface smoothing methods are required for suppression of defect in plated film.
In this study, surface smoothing and surface repairing of AMed aluminum (Al) alloy were performed by electron beam (EB) polishing with large-area EB. After the EB polishing, electroless plating was conducted on the AMed Al alloy, and suppression of defect in plated film was proposed. Experimental results show that surface smoothing, surface repairing and removal of oxidization layer of AMed Al alloy can be done simultaneously by the EB polishing. Furthermore, the plated film without defect can be successfully formed on the EB polished Al alloy. en-copyright= kn-copyright= en-aut-name=ShinonagaTogo en-aut-sei=Shinonaga en-aut-mei=Togo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsudaYuki en-aut-sei=Matsuda en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkadaAkira en-aut-sei=Okada en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Additive manufacturing kn-keyword=Additive manufacturing en-keyword=Electron beam kn-keyword=Electron beam en-keyword=Surface smoothing kn-keyword=Surface smoothing en-keyword=Surface repairing kn-keyword=Surface repairing en-keyword=Electroless plating kn-keyword=Electroless plating en-keyword=Defect kn-keyword=Defect END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue= article-no= start-page=RP99936 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250811 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Redistribution of fragmented mitochondria ensures symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes en-subtitle= kn-subtitle= en-abstract= kn-abstract=In cleavage-stage embryos, preexisting organelles partition evenly into daughter blastomeres without signi?cant cell growth after symmetric cell division. The presence of mitochondrial DNA within mitochondria and its restricted replication during preimplantation development makes their inheritance particularly important. While chromosomes are precisely segregated by the mitotic spindle, the mechanisms controlling mitochondrial partitioning remain poorly understood. In this study, we investigate the mechanism by which Dynamin-related protein 1 (Drp1) controls the mitochondrial redistribution and partitioning during embryonic cleavage. Depletion of Drp1 in mouse zygotes causes marked mitochondrial aggregation, and the majority of embryos arrest at the 2 cell stage. Clumped mitochondria are located in the center of mitotic Drp1-depleted zygotes with less uniform distribution, thereby preventing their symmetric partitioning. Asymmetric mitochondrial inheritance is accompanied by functionally inequivalent blastomeres with biased ATP and endoplasmic reticulum Ca2+ levels. We also find that marked mitochondrial centration in Drp1-depleted zygotes prevents the assembly of parental chromosomes, resulting in chromosome segregation defects and binucleation. Thus, mitochondrial fragmentation mediated by Drp1 ensures proper organelle positioning and partitioning into functional daughters during the first embryonic cleavage. en-copyright= kn-copyright= en-aut-name=GekkoHaruna en-aut-sei=Gekko en-aut-mei=Haruna kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NomuraRuri en-aut-sei=Nomura en-aut-mei=Ruri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KuzuharaDaiki en-aut-sei=Kuzuhara en-aut-mei=Daiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KaneyasuMasato en-aut-sei=Kaneyasu en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KosekiGenpei en-aut-sei=Koseki en-aut-mei=Genpei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AdhikariDeepak en-aut-sei=Adhikari en-aut-mei=Deepak kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MioYasuyuki en-aut-sei=Mio en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=CarrollJohn en-aut-sei=Carroll en-aut-mei=John kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KonoTomohiro en-aut-sei=Kono en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=FunahashiHiroaki en-aut-sei=Funahashi en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=WakaiTakuya en-aut-sei=Wakai en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Animal Science, Graduate School of Environment and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Department of Animal Science, Graduate School of Environment and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Reproductive Centre, Mio Fertility Clinic kn-affil= affil-num=4 en-affil=Department of Animal Science, Graduate School of Environment and Life Science, Okayama University kn-affil= affil-num=5 en-affil=Department of Animal Science, Graduate School of Environment and Life Science, Okayama University kn-affil= affil-num=6 en-affil=Development and Stem Cell Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University kn-affil= affil-num=7 en-affil=Reproductive Centre, Mio Fertility Clinic kn-affil= affil-num=8 en-affil=Development and Stem Cell Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University kn-affil= affil-num=9 en-affil=Department of Bioscience, Tokyo University of Agriculture kn-affil= affil-num=10 en-affil=Department of Animal Science, Graduate School of Environment and Life Science, Okayama University kn-affil= affil-num=11 en-affil=Department of Animal Science, Graduate School of Environment and Life Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=24 article-no= start-page=e195776 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251222 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Enhancement of drug delivery through fibroblast activation protein?targeted near-infrared photoimmunotherapy en-subtitle= kn-subtitle= en-abstract= kn-abstract=The tumor microenvironment plays a key role in cancer progression and therapy resistance, with cancer-associated fibroblasts (CAFs) contributing to desmoplasia, extracellular matrix (ECM) remodeling, and elevated interstitial fluid pressure, all of which hinder drug delivery. We investigated fibroblast activation protein?targeted (FAP-targeted) near-infrared photoimmunotherapy (NIR-PIT) as a strategy to improve drug penetration in CAF-rich tumors. In clinical esophageal cancer samples, FAP expression strongly correlated with increased collagen I, hyaluronic acid, and microvascular collapse. CAF-rich 3D spheroids demonstrated elevated ECM deposition and significantly impaired drug uptake compared with CAF-poor models. FAP-targeted NIR-PIT selectively reduced CAFs, reduced ECM components, and restored drug permeability. In vivo, FAP-targeted NIR-PIT enhanced the accumulation of panitumumab and Abraxane in CAF-rich tumors and improved antitumor efficacy when combined with chemotherapy. These findings highlight FAP-targeted NIR-PIT as a promising therapeutic approach to remodel the tumor stroma and overcome drug resistance in desmoplastic solid tumors. en-copyright= kn-copyright= en-aut-name=NishimuraSeitaro en-aut-sei=Nishimura en-aut-mei=Seitaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NomaKazuhiro en-aut-sei=Noma en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsumotoTasuku en-aut-sei=Matsumoto en-aut-mei=Tasuku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakedaYasushige en-aut-sei=Takeda en-aut-mei=Yasushige kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakahashiTatsuya en-aut-sei=Takahashi en-aut-mei=Tatsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsumotoHijiri en-aut-sei=Matsumoto en-aut-mei=Hijiri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawasakiKento en-aut-sei=Kawasaki en-aut-mei=Kento kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawaiHotaka en-aut-sei=Kawai en-aut-mei=Hotaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KunitomoTomoyoshi en-aut-sei=Kunitomo en-aut-mei=Tomoyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=AkaiMasaaki en-aut-sei=Akai en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KobayashiTeruki en-aut-sei=Kobayashi en-aut-mei=Teruki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NishiwakiNoriyuki en-aut-sei=Nishiwaki en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KashimaHajime en-aut-sei=Kashima en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KatoTakuya en-aut-sei=Kato en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=KikuchiSatoru en-aut-sei=Kikuchi en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=TanabeShunsuke en-aut-sei=Tanabe en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=OharaToshiaki en-aut-sei=Ohara en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=TazawaHiroshi en-aut-sei=Tazawa en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=ChoykePeter L. en-aut-sei=Choyke en-aut-mei=Peter L. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=KobayashiHisataka en-aut-sei=Kobayashi en-aut-mei=Hisataka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=3 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=4 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=5 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=6 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=7 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=8 en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=9 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=10 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=11 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=12 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=13 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=14 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=15 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=16 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=17 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=18 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=19 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= affil-num=20 en-affil=Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH kn-affil= affil-num=21 en-affil=Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH kn-affil= affil-num=22 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science kn-affil= END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=6 article-no= start-page=872 end-page=875 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=PNGase activity and free N-glycans in phloem fluid prepared from Nerium oleander (oleander tree) en-subtitle= kn-subtitle= en-abstract= kn-abstract=Free N-glycans (FNGs) occur ubiquitously in growing plants. Recently, it was reported that these FNGs interact with auxin. In this study, we investigated whether PNGase activity responsible for producing the FNGs occurs in the extracellular fluid, where auxin is present during its polar transfer. Here, we report the occurrences of PNGase activity and FNGs in the phloem fluid. en-copyright= kn-copyright= en-aut-name=OtaguroFuki en-aut-sei=Otaguro en-aut-mei=Fuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KimuraYoshinobu en-aut-sei=Kimura en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MaedaMegumi en-aut-sei=Maeda en-aut-mei=Megumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=free N-glycans kn-keyword=free N-glycans en-keyword=phloem fluid kn-keyword=phloem fluid en-keyword=Nerium oleander kn-keyword=Nerium oleander en-keyword=PNGase kn-keyword=PNGase END start-ver=1.4 cd-journal=joma no-vol=237 cd-vols= no-issue= article-no= start-page=113001 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202512 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Impact of different X-ray tube positions on actual dose measurements during CT examinations -An effect of patient physique- en-subtitle= kn-subtitle= en-abstract= kn-abstract=Dose management of patients is very important during X-ray Computed Tomography (CT) examinations, but because the patient's surface dose is inhomogeneous, it is difficult to measure the most probable value using a small passive-type dosimeter, lent to the patient. To solve this problem, our research group developed a precise dose analysis procedure in which a systematic uncertainty related to the X-ray incident direction (ƒÆin) is reduced. ƒÆin information was analyzed from CT images. However, the applicability of our procedure to actual patients with various physiques has not been examined. This study aims to propose a dose analysis procedure that can be applied to patients with various physiques, and to show its impact on dose measurement. Clinical data of 198 patients with Body Mass Index (BMI) values between 15 and 40 kg/m2 (mean value: 23.1 } 3.8 kg/m2) who underwent chest CT scans were analyzed after dividing them into three groups based on BMI values. The absorbed dose was measured with a small-type Optically Stimulated Luminescence (OSL) dosimeter. To derive correction factors related to ƒÆin, the dependence of the actually-measured dose values of various patients on ƒÆin was analyzed. The correction coefficients were determined independently for the three groups classified by BMI values. By correcting the effect of ƒÆin, the systematic uncertainty element could be reduced, resulting in 30 % reduction of the uncertainty. Furthermore, it was found that our analysis procedure makes it possible to visualize outliers. In comparison with the expected dose values based on Computed Tomography Dose Index (CTDI) values, most of the data fell within the range of }1.34 mGy (=1ƒÐ). However, 7 % of the data showed large deviations larger than 2ƒÐ. In conclusion, our research group has developed a procedure for measuring patient surface doses that can be applied to patients having various physiques, in which the effects of X-ray incident direction were accurately corrected. The procedure could be one solution to the problems with actual dose measurements during CT examinations, and will be useful for dose management based on the small-type dosimeter. en-copyright= kn-copyright= en-aut-name=HayashiHiroaki en-aut-sei=Hayashi en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MaedaTatsuya en-aut-sei=Maeda en-aut-mei=Tatsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakegamiKazuki en-aut-sei=Takegami en-aut-mei=Kazuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GotoSota en-aut-sei=Goto en-aut-mei=Sota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AsaharaTakashi en-aut-sei=Asahara en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KimotoNatsumi en-aut-sei=Kimoto en-aut-mei=Natsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NishigamiRina en-aut-sei=Nishigami en-aut-mei=Rina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KobayashiDaiki en-aut-sei=Kobayashi en-aut-mei=Daiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KanazawaYuki en-aut-sei=Kanazawa en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamashitaKazuta en-aut-sei=Yamashita en-aut-mei=Kazuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KonishiTakeshi en-aut-sei=Konishi en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MakiMotochika en-aut-sei=Maki en-aut-mei=Motochika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=College of Transdisciplinary Sciences for Innovation, Kanazawa University kn-affil= affil-num=2 en-affil=Graduate School of Medical Sciences, Kanazawa University kn-affil= affil-num=3 en-affil=Department of Radiological Technology, Yamaguchi University Hospital kn-affil= affil-num=4 en-affil=Faculty of Health Sciences, Kobe Tokiwa University kn-affil= affil-num=5 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Radiological Science, Faculty of Health Sciences, Junshin Gakuen University kn-affil= affil-num=7 en-affil=Graduate School of Medical Sciences, Kanazawa University kn-affil= affil-num=8 en-affil=Graduate School of Medical Sciences, Kanazawa University kn-affil= affil-num=9 en-affil=Faculty of Life Science, Kumamoto University kn-affil= affil-num=10 en-affil=Department of Orthopedics, School of Medicine, Tokushima University kn-affil= affil-num=11 en-affil=MEDITEC JAPAN Co., Ltd. kn-affil= affil-num=12 en-affil=MEDITEC JAPAN Co., Ltd. kn-affil= en-keyword=Patient dosimetry kn-keyword=Patient dosimetry en-keyword=Medical diagnosis kn-keyword=Medical diagnosis en-keyword=OSL dosimeter kn-keyword=OSL dosimeter en-keyword=X-ray CT kn-keyword=X-ray CT en-keyword=Passive type radiation dosimeter kn-keyword=Passive type radiation dosimeter en-keyword=BMI kn-keyword=BMI END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=3 article-no= start-page=401 end-page=407 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of Storage Temperature and a Sugar-ester Edible Coating on Postharvest Quality and Storage Life of eFuyuf Persimmon (Diospyros kaki Thunb.) en-subtitle= kn-subtitle= en-abstract= kn-abstract=In eFuyuf persimmons (Diospyros kaki Thunb.), crunchiness is a preferred postharvest attribute among both distributors and consumers. The present study first examined softening characteristics during storage at 0, 5, 10, 15, 20, and 25‹C. Fruit stored at 0‹C remained firm for 84 d, while that stored at 5‹C had a 100% softening rate within 35 d. At 10 and 15‹C, over 70% of fruit softened within 49 d and 63 d, respectively. The softening rate was relatively slower at 20 and 25‹C, with only 27% softened fruit after 56 d at 25‹C. The potential of a newly developed sugar-ester (SE) edible coating to delay fruit softening and maintain postharvest quality was then assessed during storage at 0 and 25‹C. Uncoated fruit stored at 0‹C for 56 d developed chilling injury (CI) symptoms (rapid fruit softening and peel browning) within 2 d of rewarming at 20‹C. These CI symptoms were notably mitigated in SE-coated fruit. At 25‹C, SE coating also delayed fruit softening and peel color change in addition to reducing fruit shrinkage. In conclusion, in eFuyuf persimmons ambient temperature (20?25‹C) storage in combination with an edible SE coating is recommended for the high demand Christmas and new year seasons and 0‹C storage with an edible SE coating is suitable for longer storage and distribution. en-copyright= kn-copyright= en-aut-name=MuqadasMaqsood en-aut-sei=Muqadas en-aut-mei=Maqsood kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MitaloOscar W. en-aut-sei=Mitalo en-aut-mei=Oscar W. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OhashiKyohei en-aut-sei=Ohashi en-aut-mei=Kyohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OtsukiTakumi en-aut-sei=Otsuki en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YanoChikara en-aut-sei=Yano en-aut-mei=Chikara kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HejaziZiaurrahman en-aut-sei=Hejazi en-aut-mei=Ziaurrahman kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HiraNatsuki en-aut-sei=Hira en-aut-mei=Natsuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=UshijimaKoichiro en-aut-sei=Ushijima en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KuboYasutaka en-aut-sei=Kubo en-aut-mei=Yasutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life Science, Natural Science and Technology Okayama University kn-affil= affil-num=2 en-affil=Faculty of Life and Environmental Sciences, University of Tsukuba kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life Science, Natural Science and Technology Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental, Life Science, Natural Science and Technology Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental, Life Science, Natural Science and Technology Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Agriculture, University of Miyazaki kn-affil= affil-num=7 en-affil=Shiga R&D Center, Mitsubishi Chemical Corporation kn-affil= affil-num=8 en-affil=Graduate School of Environmental, Life Science, Natural Science and Technology Okayama University kn-affil= affil-num=9 en-affil=Graduate School of Environmental, Life Science, Natural Science and Technology Okayama University kn-affil= en-keyword=chilling injury kn-keyword=chilling injury en-keyword=long-term storage kn-keyword=long-term storage en-keyword=postharvest life kn-keyword=postharvest life en-keyword=shrinkage kn-keyword=shrinkage en-keyword=softening kn-keyword=softening END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=2 article-no= start-page=346 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251223 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Judicial Doctrine on Freedom of Occupation in Japan kn-title=E‹Æ‘I‘ð‚ÌŽ©—R‚ÉŠÖ‚·‚é”»—á–@— en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ItoT. en-aut-sei=Ito en-aut-mei=T. kn-aut-name=ˆÉ“¡Œ’ kn-aut-sei=ˆÉ“¡ kn-aut-mei=Œ’ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue= article-no= start-page=100624 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Assessing water resources availability and crop performance under climate change in Kenya's Bura irrigation scheme using SWAT and AquaCrop en-subtitle= kn-subtitle= en-abstract= kn-abstract=The current study focused on Tana River Basin in Kenya, home to the Bura irrigation scheme (BIS). The BIS faces water supply shortages during critical months of crop development. This study aimed to evaluate the available water resources and crop performance using the Soil and Water Assessment Tool (SWAT) and AquaCrop, respectively, under historical and future shared socioeconomic pathways (SSPs) at the BIS. SWAT estimated the total available flows (TAF) at the BIS intake, whereas AquaCrop estimated crop water requirements (CWR), yields, and water productivity (Wpet) of rice and maize at various carbon (IV) oxide (CO2) levels. The study suggested that the TAF will remain relatively low during the early critical crop development stages in the main cropping season, August-October. Maize yields remained steady over the two cropping seasons under both constant and elevated CO2 levels in the historical and future periods, as opposed to those of rice. Elevated CO2 levels led to diminishing CWR. Moreover, rice showed a stronger response to elevated CO2 than maize. As a result, maize which is less affected by variations in CO2 and temperatures and has less crop water requirements will be better suited than rice for cultivation in the BIS under climate change. To ensure a sustainable water supply in the scheme, the government should increase rainwater harvesting during periods of high TAF. Moreover, there should be a focus on introducing crops that are tolerant to water and temperature stresses and that can reap the most from the elevated CO2 levels. en-copyright= kn-copyright= en-aut-name=WambuaDaniel Mwendwa en-aut-sei=Wambua en-aut-mei=Daniel Mwendwa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SomuraHiroaki en-aut-sei=Somura en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MoroizumiToshitsugu en-aut-sei=Moroizumi en-aut-mei=Toshitsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MaedaMorihiro en-aut-sei=Maeda en-aut-mei=Morihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= en-keyword=Climate change kn-keyword=Climate change en-keyword=Shared socioeconomic pathways kn-keyword=Shared socioeconomic pathways en-keyword=Sustainable water management kn-keyword=Sustainable water management en-keyword=Temperature stress days kn-keyword=Temperature stress days en-keyword=Water stress days kn-keyword=Water stress days en-keyword=Water productivity kn-keyword=Water productivity en-keyword=Yields kn-keyword=Yields END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=76 end-page=90 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240814 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=OsHAK4 functions in retrieving sodium from the phloem at the reproductive stage of rice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Soil salinity significantly limits rice productivity, but it is poorly understood how excess sodium (Na+) is delivered to the grains at the reproductive stage. Here, we functionally characterized OsHAK4, a member of the clade IV HAK/KUP/KT transporter subfamily in rice. OsHAK4 was localized to the plasma membrane and exhibited influx transport activity for Na+, but not for K+. Analysis of organ- and growth stage-dependent expression patterns showed that very low expression levels of OsHAK4 were detected at the vegetative growth stage, but its high expression in uppermost node I, peduncle, and rachis was found at the reproductive stage. Immunostaining indicated OsHAK4 localization in the phloem region of node I, peduncle, and rachis. Knockout of OsHAK4 did not affect the growth and Na+ accumulation at the vegetative stage. However, at the reproductive stage, the hak4 mutants accumulated higher Na+ in the peduncle, rachis, husk, and brown rice compared to the wild-type rice. Element imaging revealed higher Na+ accumulation at the phloem region of the peduncle in the mutants. These results indicate that OsHAK4 plays a crucial role in retrieving Na+ from the phloem in the upper nodes, peduncle, and rachis, thereby preventing Na+ distribution to the grains at the reproductive stage of rice. en-copyright= kn-copyright= en-aut-name=CheJing en-aut-sei=Che en-aut-mei=Jing kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamajiNaoki en-aut-sei=Yamaji en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WangShao Fei en-aut-sei=Wang en-aut-mei=Shao Fei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=XiaYue en-aut-sei=Xia en-aut-mei=Yue kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YangShun Ying en-aut-sei=Yang en-aut-mei=Shun Ying kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SuYan Hua en-aut-sei=Su en-aut-mei=Yan Hua kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShenRen Fang en-aut-sei=Shen en-aut-mei=Ren Fang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MaJian Feng en-aut-sei=Ma en-aut-mei=Jian Feng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=2 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=3 en-affil=Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences kn-affil= affil-num=4 en-affil=Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences kn-affil= affil-num=5 en-affil=Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences kn-affil= affil-num=6 en-affil=Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences kn-affil= affil-num=7 en-affil=Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences kn-affil= affil-num=8 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= en-keyword=rice kn-keyword=rice en-keyword=Oryza sativa kn-keyword=Oryza sativa en-keyword=salinity kn-keyword=salinity en-keyword=HAK transporter kn-keyword=HAK transporter en-keyword=phloem unloading kn-keyword=phloem unloading en-keyword=node kn-keyword=node END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=1773 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251216 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Single-cell and spatial transcriptomic characterization of pulmonary pleomorphic carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract=Pulmonary pleomorphic carcinoma (PPC) is a rare subtype of lung cancer that comprises both epithelial and sarcomatoid components. The molecular basis of PPC, including the cellular dynamics of its components, remains largely unknown. To elucidate potential therapeutic targets for PPC, we perform a multi-omics analysis incorporating digital spatial profiling and single-cell RNA sequencing (scRNA-seq). PPC exhibits diverse driver gene alterations, including MET exon 14 skipping mutation (METex14) and ALK fusion. In spatial transcriptomics, MET gene and protein are overexpressed exclusively within the epithelial component and not in the sarcomatoid component, even in patients harboring METex14. Epithelial-mesenchymal transition (EMT)-related transcriptional changes, along with extracellular matrix (ECM) remodeling between the epithelial and sarcomatoid components, are observed. scRNA-seq identifies cell populations within the epithelial component that contribute to the malignant transformation and differentiation of the sarcomatoid component. They are characterized by an intermediate EMT state with ECM remodeling signature, suggesting their potential as novel therapeutic targets for PPC. en-copyright= kn-copyright= en-aut-name=MatsuokaAtsushi en-aut-sei=Matsuoka en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShienKazuhiko en-aut-sei=Shien en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TomidaShuta en-aut-sei=Tomida en-aut-mei=Shuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhkiMasayoshi en-aut-sei=Ohki en-aut-mei=Masayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HisamatsuKazuya en-aut-sei=Hisamatsu en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FujiwaraRyota en-aut-sei=Fujiwara en-aut-mei=Ryota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IshimuraKosei en-aut-sei=Ishimura en-aut-mei=Kosei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FujiiRyunosuke en-aut-sei=Fujii en-aut-mei=Ryunosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HigashiharaTomoaki en-aut-sei=Higashihara en-aut-mei=Tomoaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HayashiNaohiro en-aut-sei=Hayashi en-aut-mei=Naohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OkadaKazuhiro en-aut-sei=Okada en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YoshichikaRyo en-aut-sei=Yoshichika en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MukoharaFumiaki en-aut-sei=Mukohara en-aut-mei=Fumiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YoshikawaMao en-aut-sei=Yoshikawa en-aut-mei=Mao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=FukumotoYuma en-aut-sei=Fukumoto en-aut-mei=Yuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=SuzawaKen en-aut-sei=Suzawa en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=TomiokaYasuaki en-aut-sei=Tomioka en-aut-mei=Yasuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=TanakaShin en-aut-sei=Tanaka en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=MiyoshiKentaroh en-aut-sei=Miyoshi en-aut-mei=Kentaroh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=OkazakiMikio en-aut-sei=Okazaki en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=SugimotoSeiichiro en-aut-sei=Sugimoto en-aut-mei=Seiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=OtaniYusuke en-aut-sei=Otani en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=TanakaAtsushi en-aut-sei=Tanaka en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=InoueHirofumi en-aut-sei=Inoue en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=TogashiYosuke en-aut-sei=Togashi en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= en-aut-name=YamamotoHidetaka en-aut-sei=Yamamoto en-aut-mei=Hidetaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=26 ORCID= en-aut-name=EnnishiDaisuke en-aut-sei=Ennishi en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=27 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=28 ORCID= affil-num=1 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil= kn-affil= affil-num=4 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=14 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=16 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=17 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=18 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=19 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=20 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=21 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=22 en-affil=Department of Pathology, Beth Israel Deaconess Medical Center kn-affil= affil-num=23 en-affil=Department of Pathology, Beth Israel Deaconess Medical Center kn-affil= affil-num=24 en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital kn-affil= affil-num=25 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=26 en-affil=Department of Pathology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=27 en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital kn-affil= affil-num=28 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=3 article-no= start-page=e70091 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202505 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Autoclaved lightweight aerated concrete suppressed N2O and CO2 emissions from paddy soil en-subtitle= kn-subtitle= en-abstract= kn-abstract=Autoclaved lightweight aerated concrete (AAC), a construction waste that is utilized as a soil amendment, can influence terrestrial carbon dioxide (CO2) emissions. Still, no evidence exists regarding its impact on the emission of nitrous oxide (N2O), which has a higher global warming potential. This study examined effects of AAC on CO2 and N2O emissions from paddy soil under compacted and non-compacted conditions, under 60% and 100% water-holding capacity (WHC). Samples were incubated in glass vials (25‹C) for 21 days. Emissions of CO2 and N2O were measured on days 0, 1, 3, 7, 14, and 21 using gas chromatography. The results revealed that AAC significantly (p < 0.05) lowered N2O emission rate during the whole period of incubation, while it suppressed CO2 emission rate only at the early stages (?7 days) of incubation. In compacted soil, the emissions of CO2 were significantly lower, while N2O was significantly higher than that in non-compacted soil, showing the influence of soil physical conditions. The emissions of CO2 and N2O were significantly lower at 100% WHC than those at 60% WHC. AAC suppressed both CO2 and N2O emissions under both compaction and WHC levels. The results confirm that AAC supports suppressing terrestrial emission of both CO2 and N2O, indicating that AAC has a potential as a sustainable soil amendment that enhances the climate change resilience. en-copyright= kn-copyright= en-aut-name=RathnayakeNagoda R. R. W. S. en-aut-sei=Rathnayake en-aut-mei=Nagoda R. R. W. S. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MaedaMorihiro en-aut-sei=Maeda en-aut-mei=Morihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=LeelamanieDewpura A. L. en-aut-sei=Leelamanie en-aut-mei=Dewpura A. L. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YatagaiAtsushi en-aut-sei=Yatagai en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Soil Science, Faculty of Agriculture, University of Ruhuna kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Department of Soil Science, Faculty of Agriculture, University of Ruhuna kn-affil= affil-num=4 en-affil=Clion Co. Ltd kn-affil= END start-ver=1.4 cd-journal=joma no-vol=22 cd-vols= no-issue=3 article-no= start-page=e220018 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Origin of the unique topology of the triangular water cluster in <i>Rubrobacter xylanophilus</i> rhodopsin en-subtitle= kn-subtitle= en-abstract= kn-abstract=The crystal structure of Rubrobacter xylanophilus rhodopsin (RxR) reveals a triangular cluster of three water molecules (W413, W415, and W419) at the extracellular proton-release site, near Glu187 and Glu197. Using a quantum mechanical/molecular mechanical approach, we identified the structural nature of this unique water cluster. The triangular shape is best reproduced when all three water molecules are neutral H2O with protonated Glu187 and deprotonated Glu197. Attempts to place H3O+ at any of these water molecules result in spontaneous proton transfer to one of the acidic residues and significant distortion from the crystal structure. The plane defined by the triangular water cluster extends into the guanidinium plane of Arg71, with both aligned along the W413...W419 axis. This extended plane lies nearly perpendicular to a five-membered, ring-like H-bond network involving two carboxyl oxygen atoms from Glu187 and one from Glu197. The resulting bipartite planar architecture, defined by the water triangle, Arg71, and the Glu187/Glu197 network may reflect the exceptional thermal stability in RxR. en-copyright= kn-copyright= en-aut-name=NojiTomoyasu en-aut-sei=Noji en-aut-mei=Tomoyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsujimuraMasaki en-aut-sei=Tsujimura en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SaitoKeisuke en-aut-sei=Saito en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KojimaKeiichi en-aut-sei=Kojima en-aut-mei=Keiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SudoYuki en-aut-sei=Sudo en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IshikitaHiroshi en-aut-sei=Ishikita en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo kn-affil= affil-num=2 en-affil=Department of Advanced Interdisciplinary Studies, The University of Tokyo kn-affil= affil-num=3 en-affil=Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo kn-affil= affil-num=4 en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo kn-affil= en-keyword=microbial rhodopsin kn-keyword=microbial rhodopsin en-keyword=proton transfer pathway kn-keyword=proton transfer pathway en-keyword=H3O+ kn-keyword=H3O+ en-keyword=pKa kn-keyword=pKa en-keyword=proton release group kn-keyword=proton release group END start-ver=1.4 cd-journal=joma no-vol=187 cd-vols= no-issue= article-no= start-page=106403 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202508 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Nitrogen distribution and nitrogen isotope fractionation in synthetic 2:1 phyllosilicates under hydrothermal conditions at 200?‹C and saturated vapor pressure en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study investigates nitrogen distribution and isotope fractionation within synthetic 2:1 phyllosilicates, simulating submarine hydrothermal environments at 200 ‹C and saturated vapor pressure. XRD and EDS results revealed the potential coexistence of multiple cations in the interlayer of synthetic 2:1 phyllosilicate, concurrently suggesting cation substitution in the tetrahedral and/or octahedral sheets. Meanwhile, the iron-enriched 25-5 sample exhibited restricted interlayer expansibility. NH4+ absorptions were identified in the NH4-stretching (3200?2800 cm?1) and NH4-bending (1450?1400 cm?1) regions, with wavenumber shifts indicating the influence of interlayer water removal. At pH 10.56, over 95% of nitrogen was released into the gas phase, while at pH 8.88, nitrogen proportions in the liquid and gas phases were comparable (average 48?49%). Experiments with iron at pH ?8.80 showed that the nitrogen proportion in the gas phase (average 28%) was more than twofold lower than that in the liquid phase (average 68%). Equilibrium isotope fractionation factors indicated discernible preference for heavier nitrogen isotopes in the solid phase (ƒ¿solid-liquid = 1.009?1.021 and ƒ¿solid-gas = 1.011?1.027). The ƒ¿liquid-gas range for sample 25?2 was 1.001?1.008, while that for the iron-enriched composite 25?5 was 0.997?1.010. Our experimental studies have confirmed that, in the absence of exchange interactions with external substances possessing different nitrogen isotope ratios, nitrogen isotope fractionation between ammonium and ammonia, controlled by variations in temperature and pH during mineralization, plays a crucial role in the variation of nitrogen isotope ratios. Additionally, we confirmed that metal-amines influence nitrogen isotope fractionation by modulating ammonia gas emission. These findings enhance our understanding of nitrogen cycling across the gas, liquid, and solid phases in submarine hydrothermal systems. en-copyright= kn-copyright= en-aut-name=JoJaeguk en-aut-sei=Jo en-aut-mei=Jaeguk kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamanakaToshiro en-aut-sei=Yamanaka en-aut-mei=Toshiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MiyoshiYouko en-aut-sei=Miyoshi en-aut-mei=Youko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SuzukiMasaya en-aut-sei=Suzuki en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KuwaharaYoshihiro en-aut-sei=Kuwahara en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KadotaIsao en-aut-sei=Kadota en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ChibaHitoshi en-aut-sei=Chiba en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=LeeBum Han en-aut-sei=Lee en-aut-mei=Bum Han kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Research Institute for Geo-Resources and Environment, Geological Survey of Japan, National Institute of Advanced Industrial Science and Technology (AIST) kn-affil= affil-num=4 en-affil=Research Institute for Geo-Resources and Environment, Geological Survey of Japan, National Institute of Advanced Industrial Science and Technology (AIST) kn-affil= affil-num=5 en-affil=Department of Environmental Changes, Faculty of Social and Cultural Studies, Kyushu University kn-affil= affil-num=6 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=8 en-affil=Critical Minerals Research Center, Korea Institute of Geoscience & Mineral Resources (KIGAM) kn-affil= en-keyword=Synthetic 2:1 phyllosilicates kn-keyword=Synthetic 2:1 phyllosilicates en-keyword=Nitrogen distribution kn-keyword=Nitrogen distribution en-keyword=Nitrogen isotope fractionation kn-keyword=Nitrogen isotope fractionation en-keyword=Hydrothermal system kn-keyword=Hydrothermal system END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=13 article-no= start-page=e202419624 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250129 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Conduction Band and Defect Engineering for the Prominent Visible]Light Responsive Photocatalysts en-subtitle= kn-subtitle= en-abstract= kn-abstract=Controlling trap depth is crucial to improve photocatalytic activity, but designing such crystal structures has been challenging. In this study, we discovered that in 2D materials like BiOCl and Bi4NbO8Cl, composed of interleaved [Bi2O2]2+ and Cl- slabs, the trap depth can be controlled by manipulating the slab stacking structure. In BiOCl, oxygen vacancies (VO) create deep electron traps, while chlorine vacancies (VCl) produce shallow traps. The depth is determined by the coordination around anion vacancies: VO forms strong ƒÐ bonds with Bi-6p dangling bonds below the conduction band minimum (CBM), while those around Cl are parallel, forming weak ƒÎ-bonding. The strong re-hybridization makes the trap depth deeper. In Bi4NbO8Cl, VCl also creates shallow traps, but VO does not produce deep traps although Bi-6p orbitals are also forming strong ƒÐ bonding. This difference is attributed to the difference of the energy level of CBM. In both cases, the CBM consists of Bi-6p orbitals extending into the Cl layers. However, these orbitals are isolated in BiOCl, but those in Bi4NbO8Cl are bonded with each other between neighboring [Bi2O2]2+ layers. This unique bonding-based CBM prevents the formation of deep electron traps, and significantly enhances H2 evolution activity by prolonging the lifetime of highly reactive free electrons. en-copyright= kn-copyright= en-aut-name=YamakataAkira en-aut-sei=Yamakata en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KatoKosaku en-aut-sei=Kato en-aut-mei=Kosaku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OgawaTakafumi en-aut-sei=Ogawa en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OgawaKanta en-aut-sei=Ogawa en-aut-mei=Kanta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OgawaMakoto en-aut-sei=Ogawa en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KatoDaichi en-aut-sei=Kato en-aut-mei=Daichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ZhongChengchao en-aut-sei=Zhong en-aut-mei=Chengchao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KuwabaraAkihide en-aut-sei=Kuwabara en-aut-mei=Akihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=AbeRyu en-aut-sei=Abe en-aut-mei=Ryu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KageyamaHiroshi en-aut-sei=Kageyama en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Nanostructures Research Laboratory, Japan Fine Ceramics Center kn-affil= affil-num=4 en-affil=Department of Energy and Hydrocarbon Chemistry Graduate School of Engineering, Kyoto University kn-affil= affil-num=5 en-affil=Department of Energy and Hydrocarbon Chemistry Graduate School of Engineering, Kyoto University kn-affil= affil-num=6 en-affil=Department of Energy and Hydrocarbon Chemistry Graduate School of Engineering, Kyoto University kn-affil= affil-num=7 en-affil=Department of Energy and Hydrocarbon Chemistry Graduate School of Engineering, Kyoto University kn-affil= affil-num=8 en-affil=Nanostructures Research Laboratory, Japan Fine Ceramics Center kn-affil= affil-num=9 en-affil=Department of Energy and Hydrocarbon Chemistry Graduate School of Engineering, Kyoto University kn-affil= affil-num=10 en-affil=Department of Energy and Hydrocarbon Chemistry Graduate School of Engineering, Kyoto University kn-affil= en-keyword=photocatalysis kn-keyword=photocatalysis en-keyword=defects kn-keyword=defects en-keyword=charge trapping kn-keyword=charge trapping en-keyword=recombination kn-keyword=recombination en-keyword=time-resolved spectroscopy kn-keyword=time-resolved spectroscopy END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=18 article-no= start-page=5359 end-page=5365 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Deoxygenative dual CO2 conversions: methylenation and switchable N-formylation/N-methylation of tryptamines en-subtitle= kn-subtitle= en-abstract= kn-abstract=The unprecedented one-pot synthesis of N-formyl/N-methyltryptolines from tryptamines was achieved via phenylsilane-assisted deoxygenative dual CO2 conversions. Two CO2 molecules acted as different synthons and were converted into methylene and N-formyl/N-methyl groups. The CO2 reduction step was catalyzed by a pentanuclear zinc complex at atmospheric pressure under solvent-free conditions. The N-formyl/N-methyl products could be switched by changing the amount of phenylsilane, and the amounts of in situ generated bis(silyl)acetals and silyl formates were key to the chemoselectivity. Methylenation, N-formylation, and N-methylation proceeded via the Pictet?Spengler reaction, amine?acid condensation, and the Eschweiler?Clarke reaction, respectively. The CO2 reduction with phenylsilane could also be applied to the one-pot three-step synthesis of spiro[oxindole-pyrrolidine]s. en-copyright= kn-copyright= en-aut-name=TakaishiKazuto en-aut-sei=Takaishi en-aut-mei=Kazuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MorishitaHajime en-aut-sei=Morishita en-aut-mei=Hajime kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IwakiKosuke en-aut-sei=Iwaki en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=EmaTadashi en-aut-sei=Ema en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Division of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Division of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue=4 article-no= start-page=116 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251216 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Drip Fertigation in Greenhouse Eggplant Cultivation: Reducing N2O Emissions and Nitrate Leaching en-subtitle= kn-subtitle= en-abstract= kn-abstract=Drip fertigation (DF) is a sustainable agricultural management technique that optimizes water and nutrient usage, enhances crop productivity, and reduces environmental impact. Herein, we compared the effects of DF and conventional fertilization (CF) with a basal fertilizer on yield, soil inorganic nitrogen dynamics, N2O emissions, and nitrogen leaching during facility-grown eggplant cultivation. The experiment was conducted in a greenhouse from September 2023 to May 2024, with treatments arranged in three rows and three replicates. Soil, gas, and water samples were collected and analyzed throughout the growing season. The results revealed that the DF treatment produced yields comparable to those obtained with the CF treatment while significantly reducing nitrogen and phosphorus inputs. DF effectively prevented excessive nitrogen accumulation in the soil and reduced nitrogen loss through leaching and gas emissions. N2O emissions were significantly lower by more than 60% under DF than under CF. Precise nutrient management in DF suppressed nitrification and denitrification processes, mitigating N2O emissions. DF also significantly reduced nitrogen leaching by more than 70% compared with that in CF. These findings demonstrate that DF effectively enhances agricultural sustainability by improving nutrient use efficiency, reducing greenhouse gas emissions, and minimizing nitrogen leaching during the cultivation of facility-grown eggplant. en-copyright= kn-copyright= en-aut-name=ShiraishiWataru en-aut-sei=Shiraishi en-aut-mei=Wataru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishimuraShion en-aut-sei=Nishimura en-aut-mei=Shion kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MaedaMorihiro en-aut-sei=Maeda en-aut-mei=Morihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UenoHideto en-aut-sei=Ueno en-aut-mei=Hideto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Kochi Prefectural Agricultural Research Center kn-affil= affil-num=2 en-affil=Department of Bioresource Production Science, United Graduate School of Agriculture, Ehime University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Department of Bioresource Production Science, United Graduate School of Agriculture, Ehime University kn-affil= en-keyword=drip fertigation kn-keyword=drip fertigation en-keyword=eggplant kn-keyword=eggplant en-keyword=greenhouse cultivation kn-keyword=greenhouse cultivation en-keyword=nitrogen leaching kn-keyword=nitrogen leaching en-keyword=nitrogen use efficiency kn-keyword=nitrogen use efficiency en-keyword=nitrous oxide emissions kn-keyword=nitrous oxide emissions END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=1 article-no= start-page=1387 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Tumor marker?guided precision BNCT for CA19-9?positive cancers: a new paradigm in molecularly targeted chemoradiation therapy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Boron neutron capture therapy (BNCT) is a molecularly targeted chemoradiation modality that relies on boron delivery agents such as p-borophenylalanine (BPA), which require LAT1 (L-type amino acid transporter 1) for tumor uptake. However, the limited efficacy of BPA in LAT1-low tumors restricts its therapeutic scope. To address this limitation, we developed a tumor marker?guided BNCT strategy targeting cancers overexpressing the clinically validated glycan biomarker CA19-9.
Methods: We conducted transcriptomic analyses using The Cancer Genome Atlas (TCGA) datasets to identify LAT1-low cancers with high CA19-9 expression. These analyses revealed elevated expression of fucosyltransferase 3 (FUT3), which underlies CA19-9 biosynthesis, in pancreatic, biliary, and ovarian malignancies. Based on this, we synthesized a novel boron compound, fucose-BSH, designed to selectively accumulate in CA19-9?positive tumors. We evaluated its physicochemical properties, pharmacokinetics, biodistribution, and antitumor efficacy in cell lines and xenograft models, comparing its performance to that of BPA.
Results: Fucose-BSH demonstrated significantly greater boron uptake in CA19-9?positive cell lines (AsPC-1, Panc 04.03, HuCCT-1, HSKTC, OVISE) compared to CA19-9?negative PANC-1. In HuCCT-1 xenografts, boron accumulation reached 36.2 ppm with a tumor/normal tissue ratio of 2.1, outperforming BPA. Upon neutron irradiation, fucose-BSH?mediated BNCT achieved?>?80% tumor growth inhibition. Notably, fucose-BSH retained therapeutic efficacy in LAT1-deficient models where BPA was ineffective, confirming LAT1-independent targeting.
Conclusions: This study establishes a novel precision BNCT approach by leveraging CA19-9 as a tumor-selective glycan marker for boron delivery. Fucose-BSH offers a promising platform for expanding BNCT to previously inaccessible LAT1-low malignancies, including pancreatic, biliary, and ovarian cancers. These findings provide a clinically actionable strategy for tumor marker?driven chemoradiation and lay the foundation for translational application in BNCT. This strategy has the potential to support companion diagnostic development and precision stratification in ongoing and future BNCT clinical trials.
Translational Relevance: Malignancies with elevated CA19-9 expression, such as pancreatic, biliary, and ovarian cancers, are associated with poor prognosis and limited response to current therapies. This study presents a tumor marker?guided strategy for boron neutron capture therapy (BNCT) by leveraging CA19-9 glycan biology to enable selective tumor targeting via fucose-BSH, a novel boron compound. Through transcriptomic data mining and preclinical validation, fucose-BSH demonstrated LAT1-independent boron delivery, potent BNCT-mediated cytotoxicity, and tumor-specific accumulation in CA19-9?positive models. These findings support a precision chemoradiation approach that addresses a critical gap in BNCT applicability, offering a clinically actionable pathway for patient stratification and therapeutic development in CA19-9?expressing cancers. en-copyright= kn-copyright= en-aut-name=KanehiraNoriyuki en-aut-sei=Kanehira en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TeraishiFuminori en-aut-sei=Teraishi en-aut-mei=Fuminori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TajimaTomoyuki en-aut-sei=Tajima en-aut-mei=Tomoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OsoneTatsunori en-aut-sei=Osone en-aut-mei=Tatsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=GotohKazuyoshi en-aut-sei=Gotoh en-aut-mei=Kazuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FujimotoTakuya en-aut-sei=Fujimoto en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SakuraiYoshinori en-aut-sei=Sakurai en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KondoNatsuko en-aut-sei=Kondo en-aut-mei=Natsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NagahisaNarikazu en-aut-sei=Nagahisa en-aut-mei=Narikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KameiKaoru en-aut-sei=Kamei en-aut-mei=Kaoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FujitaTaiga en-aut-sei=Fujita en-aut-mei=Taiga kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MoriharaAkira en-aut-sei=Morihara en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=TakaguchiYutaka en-aut-sei=Takaguchi en-aut-mei=Yutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KitamatsuMizuki en-aut-sei=Kitamatsu en-aut-mei=Mizuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TakaradaTakeshi en-aut-sei=Takarada en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=ShigeyasuKunitoshi en-aut-sei=Shigeyasu en-aut-mei=Kunitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=SuzukiMinoru en-aut-sei=Suzuki en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=MichiueHiroyuki en-aut-sei=Michiue en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Medical Laboratory Science, Okayama University Graduate School of Health Sciences kn-affil= affil-num=6 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Institute for Integrated Radiation and Nuclear Science, Kyoto University kn-affil= affil-num=8 en-affil=Institute for Integrated Radiation and Nuclear Science, Kyoto University kn-affil= affil-num=9 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=11 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=12 en-affil=Graduate School of Environmental, Life Science, Okayama University kn-affil= affil-num=13 en-affil=Faculty of Sustainable Design, Department of Material Design and Engineering, University of Toyama kn-affil= affil-num=14 en-affil=Department of Applied Chemistry, Kindai University kn-affil= affil-num=15 en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=16 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=17 en-affil=Institute for Integrated Radiation and Nuclear Science, Kyoto University kn-affil= affil-num=18 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=19 en-affil=Neutron Therapy Research Center, Okayama University kn-affil= en-keyword=Boron neutron capture therapy (BNCT) kn-keyword=Boron neutron capture therapy (BNCT) en-keyword=Precision BNCT kn-keyword=Precision BNCT en-keyword=Fucose-conjugated medicine kn-keyword=Fucose-conjugated medicine en-keyword=CA19-9 kn-keyword=CA19-9 en-keyword=Drug discovery kn-keyword=Drug discovery END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=10 article-no= start-page=1714 end-page=1722 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250829 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Osmotic pressure]induced calcium response states en-subtitle= kn-subtitle= en-abstract= kn-abstract=Osmotic pressure is essential for maintaining cellular homeostasis; however, the mechanisms by which cells sense and respond to acute osmotic stress remain incompletely understood. Here, we applied rapid osmotic pressure stimulation to cultured HEK293T cells and observed dynamic intracellular calcium responses. Acute hypotonic stimulation evoked calcium response patterns, whereas hypertonic and isotonic stress did not elicit similar effects. Mechanistically, these calcium signals originated from the endoplasmic reticulum via ryanodine receptor 2 and propagated to neighboring cells through Connexin 43-mediated gap junctions. These findings reveal a previously unrecognized role for calcium signaling in the acute cellular response to osmotic stress, providing new insights into the mechanisms of intercellular communication during osmotic adaptation. en-copyright= kn-copyright= en-aut-name=GaoZidan en-aut-sei=Gao en-aut-mei=Zidan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NaruseKeiji en-aut-sei=Naruse en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MorimatsuMasatoshi en-aut-sei=Morimatsu en-aut-mei=Masatoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Cardiovascular Physiology, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Okayama Japan kn-affil= affil-num=3 en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Okayama Japan kn-affil= en-keyword=calcium wave kn-keyword=calcium wave en-keyword=Connexin 43 kn-keyword=Connexin 43 en-keyword=hypotonic pressure kn-keyword=hypotonic pressure en-keyword=osmotic pressure kn-keyword=osmotic pressure en-keyword=ryanodine receptor kn-keyword=ryanodine receptor END start-ver=1.4 cd-journal=joma no-vol=133 cd-vols= no-issue=7 article-no= start-page=393 end-page=399 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250701 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Underwater superoleophobic NaNbO3-based photocatalyst thin films prepared on bare soda-lime glass by sol?gel process en-subtitle= kn-subtitle= en-abstract= kn-abstract=A self-cleaning flat transparent thin photocatalyst film was prepared on a bare soda-lime glass by a simple method using niobium alkoxide solution, which is a common coating solution for the sol?gel method. The film consisted of crystalline NaNbO3 and Na2Nb2O6?H2O phases. It was suggested that NaNbO3 and Na2Nb2O6?H2O were directly formed between the soda-lime glass and the niobium alkoxide coating solution during the heat treatment. Under UV irradiation, the film surface exhibited low photocatalytic oxidation activity and excellent photo-induced hydrophilicity. The hydrophilic state of the sample was maintained for 1 month in the dark, while the hydrophilicity of TiO2 sample prepared by a sol?gel method was decreased within 5 days in the dark. Additionally, the surface demonstrated excellent underwater oil repellency toward n-hexadecane and oleic acid and the ability to remove the adsorbed oily contaminant in water. These properties were also superior to those of the TiO2 surface. en-copyright= kn-copyright= en-aut-name=NishimotoShunsuke en-aut-sei=Nishimoto en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KageyamaKazuya en-aut-sei=Kageyama en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=EgusaShusuke en-aut-sei=Egusa en-aut-mei=Shusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KameshimaYoshikazu en-aut-sei=Kameshima en-aut-mei=Yoshikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=NaNbO3 photocatalyst kn-keyword=NaNbO3 photocatalyst en-keyword=Wettability kn-keyword=Wettability en-keyword=Self-cleaning kn-keyword=Self-cleaning en-keyword=Superhydrophilicity kn-keyword=Superhydrophilicity en-keyword=Underwater superoleophobicity kn-keyword=Underwater superoleophobicity END start-ver=1.4 cd-journal=joma no-vol=177 cd-vols= no-issue= article-no= start-page=113652 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202508 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Long-term effects of forest growth dynamics and climate change on groundwater recharge and evapotranspiration in a steep catchment of western Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=Growing water demand for human and environmental needs has led to increased reliance on groundwater resources. However, groundwater is a finite resource, and its sustainability is closely linked to recharge processes, which are influenced by forest growth dynamics as well as climate change. Evapotranspiration, largely driven by vegetation cover and climatic conditions, represents a major component of terrestrial water loss that can reduce groundwater recharge. In this study, forest growth trends, reflecting the complete developmental stages from juvenile to post-maturity of a representative species, were reconstructed using remote sensing data, forest inventories, and field studies, and incorporated into the SWAT model to evaluate their impacts on groundwater recharge and evapotranspiration as indicators of forest hydrological function and ecosystem health. The modelfs vegetation growth simulation was enhanced and uncertainty reduced by dynamically updating it with MODIS-derived leaf area index (LAI) at 5-year intervals. Groundwater recharge estimates were further improved through multi-variable calibration using Penman?Monteith?Leuning evapotranspiration (V2) and streamflow data to ensure water budget closure. Results showed that evergreen conifer growth from planting to maturity significantly reduced groundwater recharge (?4.7 mm/year) and increased evapotranspiration (+7.6 mm/year). In contrast, natural and mature deciduous broadleaf forests showed more stable recharge and evapotranspiration trends. Rising temperatures were identified as a key climatic driver of reduced recharge and increased evapotranspiration, reflecting broader global warming impacts. This study demonstrates that forest growth dynamics, especially during the critical transition from planting to maturity, alongside climate change, play a crucial role in shaping the catchmentfs water balance and offer valuable insights for sustainable groundwater management, particularly in transitional forest ecosystems. en-copyright= kn-copyright= en-aut-name=GuyoRendilicha Halake en-aut-sei=Guyo en-aut-mei=Rendilicha Halake kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WangKunyang en-aut-sei=Wang en-aut-mei=Kunyang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OnoderaShin-ichi en-aut-sei=Onodera en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SaitoMitsuyo en-aut-sei=Saito en-aut-mei=Mitsuyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MoroizumiToshitsugu en-aut-sei=Moroizumi en-aut-mei=Toshitsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Advanced Science and Engineering, Hiroshima University kn-affil= affil-num=3 en-affil=Graduate School of Advanced Science and Engineering, Hiroshima University kn-affil= affil-num=4 en-affil=Graduate School of Advanced Science and Engineering, Hiroshima University kn-affil= affil-num=5 en-affil= Graduate School of Environmental and Life Science, Okayama University kn-affil= en-keyword=Forest growth kn-keyword=Forest growth en-keyword=SWAT kn-keyword=SWAT en-keyword=Groundwater recharge kn-keyword=Groundwater recharge en-keyword=Evapotranspiration kn-keyword=Evapotranspiration en-keyword=MODIS LAI kn-keyword=MODIS LAI en-keyword=PML_V2 kn-keyword=PML_V2 en-keyword=Climate change kn-keyword=Climate change END start-ver=1.4 cd-journal=joma no-vol=163 cd-vols= no-issue=19 article-no= start-page=191101 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251120 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Interplay of coil?globule transitions and aggregation in homopolymer aqueous solutions: Simulation and topological insights en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigate the structural and topological properties of hydrophobic homopolymer chains in aqueous solutions using molecular dynamics simulations and circuit topology (CT) analysis. By combining geometric observables, such as the radius of gyration and the degree of aggregation, with CT data, we capture the relationship between coil?globule and aggregation transitions, resolving the systemfs structural changes with temperature. Our results reveal a temperature-driven collective transition from isolated coiled chains to globular aggregates. At a characteristic transition temperature Tc, each chain in multichain systems undergoes a rapid coil?globule collapse, coinciding with aggregation, in contrast to the gradual collapse observed in single-chain systems at infinite dilution. This collective transition is reflected in geometric descriptors and a reorganization of CT motifs, shifting from intrachain-dominated motifs at low temperatures to a diverse ensemble of multichain motifs at higher temperatures. CT motif enumeration provides contact statistics while offering a topologically detailed view of polymer organization. These findings highlight CTfs utility as a structural descriptor for polymer systems and suggest applications for biopolymer aggregation and folding. en-copyright= kn-copyright= en-aut-name=KomatsuJunichi en-aut-sei=Komatsu en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=BerxJonas en-aut-sei=Berx en-aut-mei=Jonas kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=2 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=3 en-affil=Niels Bohr International Academy, Niels Bohr Institute, University of Copenhagen kn-affil= END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue=1 article-no= start-page=ycaf192 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Proliferation of a bloom-forming phytoplankton via uptake of polyphosphate-accumulating bacteria under phosphate-limiting conditions en-subtitle= kn-subtitle= en-abstract= kn-abstract=Harmful algal blooms negatively impact the ecosystem and fisheries in affected areas. Eutrophication is a major factor contributing to bloom occurrence, and phosphorus is particularly important in limiting the growth of bloom-forming algae. Although algae efficiently utilize orthophosphate (Pi) as a phosphorous source over other molecular forms, Pi is often limited in the marine environment. While uptake and utilization of soluble inorganic and organic phosphorous by bloom-forming algae has been extensively studied, the details of geochemical and biological phosphorous cycling remain to be elucidated. Here, we report for the first time that the bloom-forming alga Heterosigma akashiwo can phagocytose bacteria and grow under phosphate-depleted conditions. The addition of Vibrio comitans to Pi-depleted H. akashiwo enabled the alga propagate to high cell densities, whereas other bacterial strains had only a minor effect. Importantly, V. comitans accumulates polyphosphate?a linear polymer of Pi?at high levels. The extent of algal proliferation induced by the addition of Vibrio species and polyphosphate-accumulating Escherichia coli correlated strongly with their polyphosphate content, indicating that bacterial polyphosphate served as an alternative PO43? source for H. akashiwo. The direct uptake of polyphosphate-accumulating bacteria through algal phagocytosis may represent a novel biological phosphorous-cycling pathway in marine ecosystems. The role of polyphosphate-accumulating marine bacteria as a hidden phosphorous source required for bloom formation warrants further investigation. en-copyright= kn-copyright= en-aut-name=FukuyamaSeiya en-aut-sei=Fukuyama en-aut-mei=Seiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UsamiFumiko en-aut-sei=Usami en-aut-mei=Fumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HirotaRyuichi en-aut-sei=Hirota en-aut-mei=Ryuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SatohAyano en-aut-sei=Satoh en-aut-mei=Ayano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OharaShizuka en-aut-sei=Ohara en-aut-mei=Shizuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KondoKen en-aut-sei=Kondo en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=GomibuchiYuki en-aut-sei=Gomibuchi en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YasunagaTakuo en-aut-sei=Yasunaga en-aut-mei=Takuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OndukaToshimitsu en-aut-sei=Onduka en-aut-mei=Toshimitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KurodaAkio en-aut-sei=Kuroda en-aut-mei=Akio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KoikeKazuhiko en-aut-sei=Koike en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=UekiShoko en-aut-sei=Ueki en-aut-mei=Shoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=2 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Integrated Sciences for Life, Hiroshima University kn-affil= affil-num=4 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Integrated Sciences for Life, Hiroshima University kn-affil= affil-num=6 en-affil=Research Institute of Environment, Agriculture and Fisheries , Osaka Prefecture kn-affil= affil-num=7 en-affil=Department of Physics and Information Technology, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology kn-affil= affil-num=8 en-affil=Department of Physics and Information Technology, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology kn-affil= affil-num=9 en-affil=Hatsukaichi Branch, Fisheries Technology Institute , Fisheries Research and Education Agency kn-affil= affil-num=10 en-affil=Graduate School of Integrated Sciences for Life, Hiroshima University kn-affil= affil-num=11 en-affil=Graduate School of Integrated Sciences for Life, Hiroshima University kn-affil= affil-num=12 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue= article-no= start-page=101145 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202511 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Characteristics of out-of-hospital cardiac arrest due to cerebrovascular disorders: a nationwide, retrospective, observational study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Data on out-of-hospital cardiac arrest (OHCA) due to cerebrovascular disorders is limited. This study aimed to describe the characteristics, outcomes, and annual trends of outcomes for OHCA originating from cerebrovascular disorders.
Methods: This study was a retrospective analysis using an Utstein-style Japanese National Registry. Adult patients with OHCA due to cerebrovascular disorders and transported to the hospital between 2005 and 2021 were included. The primary outcome was a favorable neurological outcome at 30-day. We analyzed factors associated with outcomes using a multivariable logistic regression model, then evaluated annual trends of outcomes for cerebrovascular-induced OHCA.
Results: Among 2,081,023 OHCA patients, 52,969 had cerebrovascular-induced cardiac arrest. Of these, 1903 (3.5 %) achieved a favorable neurological outcome. In the multivariable logistic regression model, male sex (adjusted odds ratio [aOR] 1.41, 95 % confidence interval [CI] 1.20?1.61), initial shockable rhythm (aOR 3.10, 95 % CI 2.18?4.40), witnessed cardiac arrest (aOR 1.92, 95 % CI: 1.57?2.34), and prehospital return of spontaneous circulation (ROSC) (aOR 11.1, 95 % CI: 9.09?13.5) were associated with favorable neurological outcomes. Prehospital adrenaline administration was negatively associated with favorable neurological outcomes (aOR 0.22, 95 % CI: 0.16?0.30). The proportion of patients with favorable neurological outcomes increased over time, rising from 3.14 % in 2005 to 4.12 % in 2021.
Conclusions: Although OHCA due to cerebrovascular disorders is generally associated with poor neurological outcomes, 3.5 % of the patients with cerebrovascular-induced OHCA in this study had favorable neurological outcomes, with a yearly trend improving over decades. Patient characteristics associated with a higher likelihood of a favorable neurological outcome included prehospital ROSC, initial shockable rhythm, and witnessed cardiac arrest. en-copyright= kn-copyright= en-aut-name=UedaYoshiyuki en-aut-sei=Ueda en-aut-mei=Yoshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NojimaTsuyoshi en-aut-sei=Nojima en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ObaraTakafumi en-aut-sei=Obara en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HongoTakashi en-aut-sei=Hongo en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YumotoTetsuya en-aut-sei=Yumoto en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TsukaharaKohei en-aut-sei=Tsukahara en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Emergency, Critical Care, and Disaster Medicine kn-affil= affil-num=2 en-affil=Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Emergency, Critical Care, and Disaster Medicine kn-affil= affil-num=3 en-affil=Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Emergency, Critical Care, and Disaster Medicine kn-affil= affil-num=4 en-affil=Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Emergency, Critical Care, and Disaster Medicine kn-affil= affil-num=5 en-affil=Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Emergency, Critical Care, and Disaster Medicine kn-affil= affil-num=6 en-affil=Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Emergency, Critical Care, and Disaster Medicine kn-affil= affil-num=7 en-affil=Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Epidemiology kn-affil= affil-num=8 en-affil=Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Emergency, Critical Care, and Disaster Medicine kn-affil= affil-num=9 en-affil=Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Emergency, Critical Care, and Disaster Medicine kn-affil= en-keyword=Cardiac arrest kn-keyword=Cardiac arrest en-keyword=Cardiopulmonary resuscitation kn-keyword=Cardiopulmonary resuscitation en-keyword=Cerebral hemorrhage kn-keyword=Cerebral hemorrhage en-keyword=Stroke kn-keyword=Stroke en-keyword=Subarachnoid hemorrhage kn-keyword=Subarachnoid hemorrhage END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=e21664 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251014 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Biologically-Architected Wear and Damage-Resistant Nanoparticle Coating From the Radular Teeth of Cryptochiton stelleri en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nature utilizes simple building blocks to construct mechanically robust materials that demonstrate superior performance under extreme conditions. These exquisite structures result from the controlled synthesis and hierarchical assembly of nanoscale organic and mineral components that have provided critical evolutionary advantages to ensure survival. One such example is the ultrahard radular teeth found in mollusks, which are used to scrape against rock to feed on algae. Here, it is reported that the leading edges of these teeth consist of a wear-resistant coating that is comprised of densely packed ?65 nm magnetic nanoparticles integrated within an organic matrix of chitin and protein. These mesocrystalline magnetite-based structures are assembled from smaller, highly aligned nanocrystals with inter/intracrystalline organics introduced during the crystallization process. Nanomechanical testing reveals that this multi-scale, nano-architected coating has a combination of increased hardness and a slight decrease in modulus versus geologic magnetite provides the surface of the chiton tooth with superior abrasion resistance. The mesocrystalline structures fracture at primary domain interfaces, corroborated by computational models, providing significant toughening to the tooth under extreme contact stresses. The design features revealed provide insight for the design and fabrication of next-generation advanced wear- and impact-resistant coatings for tooling, machinery, wind turbines, armor, etc. en-copyright= kn-copyright= en-aut-name=WangTaifeng en-aut-sei=Wang en-aut-mei=Taifeng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ChenYu en-aut-sei=Chen en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SarmientoEzra en-aut-sei=Sarmiento en-aut-mei=Ezra kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HaoTaige en-aut-sei=Hao en-aut-mei=Taige kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ArakakiAtsushi en-aut-sei=Arakaki en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NemotoMichiko en-aut-sei=Nemoto en-aut-mei=Michiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ZavattieriPablo en-aut-sei=Zavattieri en-aut-mei=Pablo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KisailusDavid en-aut-sei=Kisailus en-aut-mei=David kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Materials Science and Engineering, University of California kn-affil= affil-num=2 en-affil=Lyles School of Civil and Construction Engineering, Purdue University kn-affil= affil-num=3 en-affil=Department of Materials Science and Engineering, University of California kn-affil= affil-num=4 en-affil=Materials and Manufacturing Technologies Program, University of California kn-affil= affil-num=5 en-affil=Division of Biotechnology and Life Science, Institute of Engineering, Tokyo University of Agriculture and Technology kn-affil= affil-num=6 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=7 en-affil=Lyles School of Civil and Construction Engineering, Purdue University kn-affil= affil-num=8 en-affil=Department of Materials Science and Engineering, University of California kn-affil= en-keyword=biomineralization kn-keyword=biomineralization en-keyword=coatings kn-keyword=coatings en-keyword=damage tolerance kn-keyword=damage tolerance en-keyword=magnetite kn-keyword=magnetite en-keyword=mesocrystals kn-keyword=mesocrystals END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=40608 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251118 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association between gestational age and child health and neurodevelopment in twins from a nationwide longitudinal survey in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=Despite previous research, evidence on the relationship between gestational age and long-term health and neurodevelopmental outcomes among twins remains limited. Using data from the Longitudinal Survey of Babies in the 21st Century, we analyzed 549 twins born in Japan in 2010. The twins were grouped by gestational age: <32 weeks (very preterm), 32?36 weeks (moderately and late preterm), and 37?38 weeks (early term). The health status was evaluated by hospitalization between 0.5 and 5.5 years, and behavioral development was assessed using questionnaires at 2.5 and 5.5 years. Binomial log-linear regression with generalized estimating equations accounted for within-pair correlations and adjusted for child and parental variables. Moderately and late preterm children showed a higher risk of all-cause hospitalization during infancy than early-term children (adjusted risk ratio, 1.7; 95% CI, 1.0?2.6). Very preterm children showed a higher point estimate of the risk ratio, but a wide CI (risk ratio, 2.3; 95% CI, 0.8?6.8). Behavioral delays were more common in preterm groups at 2.5 years but not at 5.5 years. Preterm twins have a higher risk of hospitalization during infancy and developmental delay at 2.5 years than early-term twins. These risks show an increasing trend as gestational age decreases. en-copyright= kn-copyright= en-aut-name=TamaiKei en-aut-sei=Tamai en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoNaomi en-aut-sei=Matsumoto en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakeuchiAkihito en-aut-sei=Takeuchi en-aut-mei=Akihito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakamuraMakoto en-aut-sei=Nakamura en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KageyamaMisao en-aut-sei=Kageyama en-aut-mei=Misao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Division of Neonatology, NHO Okayama Medical Center kn-affil= affil-num=4 en-affil=Division of Neonatology, NHO Okayama Medical Center kn-affil= affil-num=5 en-affil=Division of Neonatology, NHO Okayama Medical Center kn-affil= affil-num=6 en-affil=Department of Epidemiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Behavioral development kn-keyword=Behavioral development en-keyword=Child health kn-keyword=Child health en-keyword=Early term kn-keyword=Early term en-keyword=Gestational age kn-keyword=Gestational age en-keyword=Hospitalization kn-keyword=Hospitalization en-keyword=Multiple births kn-keyword=Multiple births END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=10 article-no= start-page=e95695 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251029 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Association of Use of GRADE, Protocol Registration, and Journal Impact Factor With Reporting and Methodological Quality of Systematic Reviews Published in Rehabilitation Journals: A Meta-Epidemiological Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study aimed to identify factors associated with the reporting and methodological quality of systematic reviews (SRs) published in rehabilitation journals. We conducted a meta-epidemiological study as a secondary analysis of a previous study. The study protocol was registered in the Open Science Framework. We analyzed 219 SRs from rehabilitation journals published since 2020. We assessed reporting quality using the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) 2020 and methodological quality using A MeaSurement Tool to Assess systematic Reviews (AMSTAR) 2. Multiple linear regression and Spearman's correlation were used to identify factors associated with quality, including Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach and the Journal Impact Factor (JIF). Multivariate analysis revealed PRISMA 2020 adherence was significantly associated with use of GRADE (ƒÀ = 4.33; 95% confidence interval (CI): 3.24-5.42), protocol registration (ƒÀ = 3.40; 95% CI: 2.32-4.47), and the JIF (2023) (ƒÀ = 0.69; 95% CI: 0.42-0.95). AMSTAR 2 adherence was also significantly associated with use of GRADE (ƒÀ = 2.52; 95% CI: 1.88-3.17), protocol registration (ƒÀ = 2.07; 95% CI: 1.44-2.70), and the JIF (2023) (ƒÀ = 0.29; 95% CI: 0.14-0.45). Weak positive correlations were observed between the JIF (2023) and both PRISMA 2020 and AMSTAR 2 adherence (ƒÏ = 0.27 and ƒÏ = 0.22, respectively; both P < 0.01). It should be noted that these findings reflect associations and do not imply causality. To enhance the quality of SRs in rehabilitation, researchers should prioritize adherence to PRISMA 2020, particularly the use of GRADE and protocol registration, which this study identified as key associated factors. en-copyright= kn-copyright= en-aut-name=TsugeTakahiro en-aut-sei=Tsuge en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamamotoNorio en-aut-sei=Yamamoto en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TomitaYosuke en-aut-sei=Tomita en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HagiyamaAkikazu en-aut-sei=Hagiyama en-aut-mei=Akikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ShiratsuchiDaijo en-aut-sei=Shiratsuchi en-aut-mei=Daijo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkamuraMasatsugu en-aut-sei=Okamura en-aut-mei=Masatsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KanekoTakao en-aut-sei=Kaneko en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SuzukiKosuke en-aut-sei=Suzuki en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NakashimaYuki en-aut-sei=Nakashima en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TaitoShunsuke en-aut-sei=Taito en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Systematic Reviewers, Scientific Research WorkS Peer Support Group (SRWS-PSG) kn-affil= affil-num=3 en-affil=Physical Therapy, Faculty of Health Care, Takasaki University of Health and Welfare kn-affil= affil-num=4 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University kn-affil= affil-num=6 en-affil=Systematic Reviewers, Scientific Research WorkS Peer Support Group (SRWS-PSG) kn-affil= affil-num=7 en-affil=Rehabilitation, Yamagata Prefectural Central Hospital kn-affil= affil-num=8 en-affil=Rehabilitation, Yamagata Saisei Hospital kn-affil= affil-num=9 en-affil=Systematic Reviewers, Scientific Research WorkS Peer Support Group (SRWS-PSG) kn-affil= affil-num=10 en-affil=Systematic Reviewers, Scientific Research WorkS Peer Support Group (SRWS-PSG) kn-affil= affil-num=11 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=citation kn-keyword=citation en-keyword=grade kn-keyword=grade en-keyword=journal impact factor kn-keyword=journal impact factor en-keyword=methodological and reporting quality kn-keyword=methodological and reporting quality en-keyword=prisma kn-keyword=prisma END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1 article-no= start-page=100720 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202602 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Dynamin 2 is involved in osteoblast migration by regulating the organization of F-actin en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objectives: Dynamin, a GTPase that regulates membrane dynamics, has recently been implicated in actin cytoskeletal remodeling. This study aimed to elucidate the role of dynamin in osteoblast migration by examining the effects of dynamin inhibition on the localization and organization of F-actin and dynamin 2 in MC3T3-E1 cells.
Methods: MC3T3-E1 cells were treated with dynamin inhibitors (Dyngo 4a and Dynole 34-2), and cell migration was assessed using a wound-healing assay. Fluorescent staining was performed to analyze the intracellular localization of F-actin and dynamin 2.
Results: Dynamin inhibition significantly reduced the migration of MC3T3-E1 cells. Fluorescence analysis revealed a marked decrease in the accumulation and colocalization of F-actin and dynamin 2 at the protrusion edge. Additionally, dynamin inhibition suppressed the formation of lamellipodia and stress fibers while promoting the appearance of abnormal F-actin clusters in the cytoplasm.
Conclusions: These findings suggest that dynamin plays an essential role in osteoblast migration by regulating actin cytoskeletal remodeling, particularly through the formation of lamellipodia and stress fibers. en-copyright= kn-copyright= en-aut-name=MoriyaTakumi en-aut-sei=Moriya en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SurongA. en-aut-sei=Surong en-aut-mei=A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TatsumiNanami en-aut-sei=Tatsumi en-aut-mei=Nanami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamadaHiroshi en-aut-sei=Yamada en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakemotoFumiko en-aut-sei=Takemoto en-aut-mei=Fumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KamiokaHiroshi en-aut-sei=Kamioka en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkamuraHirohiko en-aut-sei=Okamura en-aut-mei=Hirohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IkegameMika en-aut-sei=Ikegame en-aut-mei=Mika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Orthodontics, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical 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