result 23280 件
| Author | Doi, Hiroyuki| |
|---|---|
| Published Date | 2008-01-04 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Miyazaki, Ikuko| Asanuma, Masato| Francisco J. Diaz-Corrales| Miyoshi, Ko| Ogawa, Norio| |
|---|---|
| Published Date | 2008-01-04 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue3 |
| Content Type | Journal Article |
| Title Alternative | Adenoviral p53 gene therapy for lung cancer |
|---|---|
| FullText URL | 119_229.pdf |
| Author | Fujiwara, Toshiyoshi| Tanaka, Noriaki| |
| Abstract | To determine the feasibility, safety, humoral immune response, and biological activity of multiple intratumoral injections of Ad5CMV-p53, and to characterize the pharmacokinetics of Ad5CMV-p53 in patients with advanced non-small cell lung cancer (NSCLC). Fifteen patients with histologically confirmed NSCLC and p53 mutations were enrolled into this phase I trial. Nine patients received escalating dose levels of Ad5CMV-p53 (1 × 109 to 1 × 1011 plaque-forming units[PFU]) as monotherapy once every 4 weeks. Six patients were treated on a 28-day schedule with Ad5CMV-p53 in combination with intravenous administration of cisplatin (80 mg/m2). Patients were monitored for toxicity, vector distribution, antibody formation, and tumor response. Fifteen patients received a total of 63 intratumoral injections of Ad5CMV-p53 without dose-limiting toxicity. The most common treatment-related toxicity was a transient fever. Specific p53 transgene expression was detected using reverse-transcriptase polymerase chain reaction in biopsied tumor tissues throughout the period of treatment despite of the presence of neutralizing anti-adenovirus antibody. Distribution studies revealed that the vector was detected in the gargle and plasma, but rarely in the urine. Thirteen of 15 patients were assessable for efficacy; one patient had a partial response (squamous cell carcinoma at the carina), 10 patients had stable disease, with three lasting ≥9 months, and 2 patients had progressive disease. Multiple courses of intratumoral Ad5CMV-p53 injection alone or in combination with intravenous administration of cisplatin were feasible and well tolerated in advanced NSCLC patients, and appeared to provide clinical benefit. |
| Keywords | p53 遺伝子 アデノウイルスベクター (adenovirus vector) 肺癌 (lung cancer) 臨床試験 (clinical trial) |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2008-01-04 |
| Volume | volume119 |
| Issue | issue3 |
| Start Page | 229 |
| End Page | 234 |
| ISSN | 00301558 |
| language | Japanese |
| Copyright Holders | 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.119.229 |
| NAID | 10020282723 |
| Author | Sunahori, Katsue| Yamamura, Masahiro| Yamana, Jiro| Takasugi, Koji| Makino, Hirofumi| |
|---|---|
| Published Date | 2008-01-04 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | 岡山医学会| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Others |
| Author | Otsuka, Fumio| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Article |
| Author | Ishizu, Hideo| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Article |
| Author | 村下 純二| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Article |
| Author | 難波 義夫| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Article |
| Author | Higashi, Toshihiro| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Sato, Tomoaki| Ueshima, Satoshi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Hiramatsu, Yuji| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kataoka, Hitomi| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Matsuoka, Junji| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Fujiwara, Satoko| Sendo, Toshiaki| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nishimoto, Hitomi| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Doihara, Hiroyoshi| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kawakita, Norifumi| Miyatake, Nobuyuki| Takigawa, Tomoko| Wang, Da-Hong| Ogino, Keiki| Numata, Takeyuki| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Ikeguchi, Gosen T.| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Jin, Yingji| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
