result 314 件
| JaLCDOI | 10.18926/AMO/61877 |
|---|---|
| FullText URL | 75_2_115.pdf |
| Author | Hitomi, Nishizaki| Yoshinari, Morimoto| Yamada, Shin-ichi| Kurita, Hiroshi| Tanaka, Akira| Yamaguchi, Akira| Miyata, Masaru| Yoshikawa, Hiromasa | Yanamoto, Souichi| Imai, Yutaka| |
| Abstract | The aim of this study was to investigate the awareness and experience, among dental practitioners, of adverse events resulting from dental treatment of patients undergoing therapy with drugs that affect the immune system [angiogenesis inhibitors, biological agents, immunosuppressants, and disease-modifying anti-rheumatic drugs (DMARDs)]. For this purpose, a nationwide questionnaire survey was conducted. Questionnaires were sent to 2,050 dentists, of which 206 (10.1%) were completed and returned. The results showed that most dentists were aware of complications associated with dental treatment of patients treated with drugs that affect the immune system, and about half had actually experienced such complications. Delayed wound healing, osteonecrosis of the jaw (ONJ), and postoperative infections were reported. Whereas approximately 50% of dentists did not discontinue the drugs during dental treatment, about 18% did. During temporary drug discontinuation, some patients experienced aggravation of the primary disease, such as worsening of rheumatism, growth of tumors, and rejection reactions of transplanted organs. As for medical cooperation, only less than half of the dentists were asked for oral hygiene management by a physician prior to starting the drug treatment. Prospective studies are needed because evidence for dental treatments in patients treated with these drugs remains limited. |
| Keywords | angiogenesis inhibitor biological agent disease-modifying antirheumatic drug (DMARD) immunosuppressant medication-related osteonecrosis of the jaw (MRONJ) |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 115 |
| End Page | 123 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953417 |
| NAID | 120007029906 |
| FullText URL | fulltext20210506_1.pdf |
|---|---|
| Author | Ninomiya, Kiichiro| Teraoka, Shunsuke| Zenke, Yoshitaka| Kenmotsu, Hirotsugu| Nakamura, Yukiko| Okuma, Yusuke| Tamiya, Akihiro| Nosaki, Kaname| Morise, Masahiro| Aokage, Keiju| Oya, Yuko| Kozuki, Toshiyuki| Sakamoto, Tomohiro| Tanaka, Kentaro| Tanaka, Hisashi| Tanizaki, Junko| Miura, Satoru| Mizutani, Hideaki| Miyauchi, Eisaku| Yamaguchi, Ou| Ebi, Noriyuki| Goto, Yasushi| Sasaki, Takaaki| Daga, Haruko| Morita, Satoshi| Yamanaka, Takeharu| Amano, Shinsuke| Hasegawa, Kazuo| Imamura, Chiyo K.| Suzuki, Kenichi| Nakajima, Kazuko| Nishimoto, Hitomi| Oizumi, Satoshi| Hida, Toyoaki| Hotta, Katsuyuki| Takiguchi, Yuichi| |
| Keywords | Non–small cell lung cancer Epidermal growth factor receptor Systematic review Guidelines |
| Published Date | 2021-01-31 |
| Publication Title | JTO Clinical and Research Reports |
| Volume | volume2 |
| Issue | issue1 |
| Publisher | Elsevier |
| Start Page | 100107 |
| ISSN | 26663643 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| DOI | 10.1016/j.jtocrr.2020.100107 |
| NAID | 120007032762 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jtocrr.2020.100107 |
| FullText URL | fulltext20210525_3.pdf |
|---|---|
| Author | Sasaki, Tomoaki| Ogata, Miki| Kajihama, Aya| Nakau, Kouichi| Okizaki, Atsutaka| |
| Keywords | Mucopolysaccharidosis type 2 Dysostosis Cranial hyperostosis |
| Published Date | 2021-03-31 |
| Publication Title | Radiology Case Reports |
| Volume | volume16 |
| Issue | issue3 |
| Publisher | Elsevier |
| Start Page | 656 |
| End Page | 660 |
| ISSN | 19300433 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Authors. |
| File Version | publisher |
| PubMed ID | 33488893 |
| DOI | 10.1016/j.radcr.2021.01.003 |
| Related Url | isVersionOf https://doi.org/10.1016/j.radcr.2021.01.003 |
| FullText URL | fulltext20210530_1.pdf |
|---|---|
| Author | Laukhtina, Ekaterina| Pradere, Benjamin| Mori, Keiichiro| Schuettfort, Victor M.| Quhal, Fahad| Mostafaei, Hadi| Sari Motlangh, Reza| Katayama, Satoshi| Grossmann, Nico C.| Moschini, Marco| Enikeev, Dmitry| Shariat, Shahrokh F.| |
| Keywords | Biomarkers UCB bladder cancer Neoadjuvant systemic therapy NAC systematic review |
| Published Date | 2021-03-31 |
| Publication Title | Urologic Oncology: Seminars and Original Investigations |
| Volume | volume39 |
| Issue | issue3 |
| Publisher | Elsevier |
| Start Page | 180 |
| End Page | 190 |
| ISSN | 10781439 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Authors. |
| File Version | publisher |
| PubMed ID | 33423937 |
| DOI | 10.1016/j.urolonc.2020.12.019 |
| Web of Science KeyUT | 000620260700027 |
| Related Url | isVersionOf https://doi.org/10.1016/j.urolonc.2020.12.019 |
| JaLCDOI | 10.18926/CTED/61581 |
|---|---|
| Title Alternative | A Review of Interventions for Students with Dyscalculia |
| FullText URL | cted_011_293_306.pdf |
| Author | SUEHIRO, Kumiko| Ohmori, Iori| |
| Abstract | 本研究の目的は、中学校通常学級での算数障害生徒への学習支援に関する研究・実践について整理し、支援の方法及び内容と今後の課題を明らかにすることである。中学校・高等学校での学習支援に関する実践論文を中心に文献調査を行い、①学習形態②ICT や教材教具 ③学習内容④学習意欲の４つに焦点をあてて検討した。生徒の障害特性のアセスメントをもとに適切な学習形態や教材を選択すること、支援体制を構築することの重要性が明らかになった。学習内容では、「数と式」領域に個別の支援の実践例が多いこと、学習意欲では、算数障害生徒は心理的サポートが必要であり、生徒の気持ちを尊重しながら支援する必要があることが指摘されていた。ICT を活用した新しい支援方法や内容とその効果の検証、及び算数障害生徒の個々の特性に合わせた学習支援コンテンツの開発が今後の課題であり、生徒の状況に応じた柔軟な支援法を選択していくことが重要であると言える。 |
| Keywords | 算数障害 (Dyscalculia) 学習障害 (learning disability) 学習支援 (learning support) 中学校 (Junior high school) |
| Publication Title | Bulletin of Center for Teacher Education and Development, Okayama University |
| Published Date | 2021-03-22 |
| Volume | volume11 |
| Start Page | 293 |
| End Page | 306 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2021 岡山大学教師教育開発センター |
| File Version | publisher |
| JaLCDOI | 10.18926/AMO/61442 |
|---|---|
| FullText URL | 75_1_95.pdf |
| Author | Minato, Keitaro| Hirano, Toru| Kawashima, Hiroyuki| Yamagishi, Tetsuro| Watanabe, Keigo| Ohashi, Masayuki| Ogose, Akira| Endo, Naoto| |
| Abstract | A 21-year-old man consulted our hospital for treatment of a spinal giant cell tumor (GCT) of Enneking stage III. Lower lumbar-spine tumors and severe spinal canal stenosis are associated with high risk for surgical mor-bidity. Stability was temporarily secured with a percutaneous pedicle screw fixation in combination with deno-sumab, which shrank the tumor. Total en bloc spondylectomy was then performed 6 months after initiation of denosumab, and the patient was followed for 3 years. There was no local recurrence, and bony fusion was obtained. Minimally invasive surgery and denosumab allowed safer and easier treatment of a collapsing lower lumbar extra-compartmental GCT. |
| Keywords | spinal stabilization denosumab spondylectomy giant cell tumor |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 95 |
| End Page | 101 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649620 |
| JaLCDOI | 10.18926/AMO/61437 |
|---|---|
| FullText URL | 75_1_71.pdf |
| Author | Sanki, Tomoaki| Tetsunaga, Tomonori| Furumatsu, Takayuki| Yamada, Kazuki| Kawamura, Yoshi| Ozaki, Toshifumi| |
| Abstract | Intra-operative acetabular fracture is a total hip arthroplasty complication that can occur during cementless cup insertion, especially in osteoporotic patients. We conducted this biomechanical study to investigate the impact resistance of the acetabulum with simulated bones of different density by drop-weight impact testing. Low- and high-density polyurethane foam blocks were used as osteoporotic and healthy bone models, respectively. Polyurethane blocks were used as the acetabular cancellous bone. Composite sheets were used as the acetabu-lum’s medial cortex. The testing revealed that the osteoporotic bone model’s impact resistance was significantly lower than that the healthy bone model’. In the healthy bone model, even thin acetabular cancellous bone with ≥ 1 mm acetabulum medial cortex was less likely to fracture. In the osteoporotic bone model, fracture was pos-sible without ≥ 1 mm medial cortex of the acetabulum and thick acetabular cancellous bone. Although impac-tion resistance differs due to bone quality, the impaction resistance in this osteoporotic bone model was equiv-alent to that healthy bone model’s when a thick medial wall was present. To avoid intra-operative acetabulum fracture, surgeons should consider both the bone quality and the thicknesses of the medial cortex and acetabu-lar cancellous bone. |
| Keywords | intra-operative acetabular fracture drop weight impact testing total hip arthroplasty impact resistance |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 71 |
| End Page | 77 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649616 |
| JaLCDOI | 10.18926/AMO/61428 |
|---|---|
| FullText URL | 75_1_9.pdf |
| Author | Gobara, Hideo| Yamamoto, Akira| Komakic, Toshiyuki| Kitayama, Toshiaki| Sakurai, Jun| Iguchi, Toshihiro| Matsui, Yusuke| Uka, Mayu| Tomita, Koji| Hiraki, Takao| Kanazawa, Susumu| |
| Abstract | To assess the feasibility of needle tract ablation in liver tissue in ex vivo and in vivo animal models using a cryo-probe and electrosurgical device. The experimental device is made by inserting a cryoprobe through an intro-ducer sheath for insulation, with 2-cm of probe tip projecting out. A beagle liver was punctured by the device, and electric current was applied at 30-W with the electrosurgical knife touching the non-insulated device base. The discolored area of cut surface along the device was evaluated in 5 application-time groups (5 , 10 , 15 , 20, or 25 seconds). An ex vivo experiment was performed to determine an ablation algorithm with an appropriate application time by comparison with radiofrequency ablation (RFA) results. Thereafter, an in vivo experiment was performed to verify the algorithm’s feasibility. In the ex vivo model, the cut surface demonstrated different amounts of discolored area according to the application time. The total discolored area in the 20-seconds group was similar to that by RFA. In the in vivo model, the liver did not bleed, the total discolored area was similar to that ex vivo, and coagulation necrosis was confirmed by photomicrograph. Needle tract ablation can be per-formed using the experimental device and electrosurgical device. |
| Keywords | needle tract ablation cryoablation electrosurgical device animal liver |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 9 |
| End Page | 14 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649608 |
| JaLCDOI | 10.18926/61334 |
|---|---|
| Title Alternative | A Review of Literature on Telecommuting and Firmsʼ Innovation |
| FullText URL | hss_50_089.pdf |
| Author | Moriuchi, Yasushi| |
| Publication Title | Journal of Humanities and Social Sciences |
| Published Date | 2021-01-27 |
| Volume | volume50 |
| Start Page | 89 |
| End Page | 103 |
| ISSN | 1881-1671 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2021 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120007004806 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Urata, Haruo| Tanaka, Takehiro| Okada, Hiroyuki| |
| Keywords | Lanthanum carbonate Hyperphosphatemia Gastrointestinal endoscopy Lanthanum phosphate Scanning electron microscopy Energy-dispersive X-ray spectrometry |
| Published Date | 2020-04-07 |
| Publication Title | World Journal of Gastroenterology |
| Volume | volume26 |
| Issue | issue13 |
| Publisher | Baishideng Publishing Group |
| Start Page | 1439 |
| End Page | 1449 |
| ISSN | 1007-9327 |
| NCID | AA11690631 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | ©The Author(s) 2020. |
| File Version | publisher |
| PubMed ID | 32308345 |
| DOI | 10.3748/wjg.v26.i13.1439 |
| Web of Science KeyUT | 000536263200004 |
| Related Url | isVersionOf https://dx.doi.org/10.3748/wjg.v26.i13.1439 |
| Author | Kobayashi, Hiroki| Asada, Noboru| Igawa, Takuro| Abe, Masaya| Meguri, Yusuke| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Nobuharu| Matsuoka, Ken-ichi| Yoshino, Tadashi| Maeda, Yoshinobu| |
|---|---|
| Keywords | adult T-cell leukemia-lymphoma breast involvement positron emission tomography/computed tomography |
| Published Date | 2020-11-01 |
| Publication Title | Internal Medicine |
| Volume | volume59 |
| Issue | issue21 |
| Publisher | 日本内科学会 |
| Start Page | 2757 |
| End Page | 2761 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by The Japanese Society of Internal Medicine |
| File Version | publisher |
| DOI | 10.2169/internalmedicine.5077-20 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.5077-20 |
| JaLCDOI | 10.18926/AMO/61213 |
|---|---|
| FullText URL | 74_6_531.pdf |
| Author | Hashimoto, Kazuhiko| Nishimura, Shunji| Chikugo, Takaaki| Kakinoki, Ryosuke| Akagi, Masao| |
| Abstract | Soft tissue myoepitheliomas are often misdiagnosed due to their rarity. Herein, we describe a case of soft tissue myoepithelioma of the shoulder. A 72-year-old woman had a suspected sarcoma on her shoulder and under-went open biopsy. She was referred to our hospital, where the tumor was widely resected and the diagnosis of myoepithelioma was histologically confirmed. No recurrence has been observed in the 3 years since the sur-gery. Careful and prompt planning is necessary for the effective treatment of myoepithelioma. |
| Keywords | soft tissue myoepithelioma unplanned resection shoulder |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 531 |
| End Page | 535 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361874 |
| Web of Science KeyUT | 000601203600010 |
| NAID | 120006948952 |
| JaLCDOI | 10.18926/AMO/61212 |
|---|---|
| FullText URL | 74_6_525.pdf |
| Author | Aoki, Hideki| Utsumi, Masashi| Kimura, Yuji| Takahashi, Yosuke| Nagahisa, Seiichi| Nishimura, Seitaro| Une, Yuta| Watanabe, Megumi| Taniguchi, Fumitaka| Arata, Takashi| Katsuda, Koh| Tanakaya, Kohji| |
| Abstract | Cardiac metastasis originating from hepatocellular carcinoma (HCC) is a rare condition with a poor prognosis. No therapeutic standards for cardiac metastasis originating from HCC have been established. At 19 months after a curative hepatectomy, a 64-year-old Japanese hepatitis B virus-positive male patient experienced solitary cardiac metastasis originating from HCC. The cardiac tumor was discovered in the right ventricle. The patient received three courses of radiotherapy and chemotherapy and survived > 3 years after the initial diagnosis of cardiac metastasis. His case demonstrates that radiotherapy combined with chemotherapy can be an effective treatment for cardiac metastasis. |
| Keywords | hepatocellular carcinoma cardiac metastasis radiotherapy chemotherapy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 525 |
| End Page | 530 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361873 |
| Web of Science KeyUT | 000601203600009 |
| NAID | 120006948951 |
| JaLCDOI | 10.18926/AMO/61211 |
|---|---|
| FullText URL | 74_6_521.pdf |
| Author | Itazaki, Yujiro| Tsujimoto, Hironori| Sugasawa, Hidekazu| Yaguchi, Yoshihisa| Nomura, Shinsuke| Ito, Nozomi| Harada, Manabu| Sugihara, Takao| Tsuchiya, Satoshi| Ishibashi, Yusuke| Kouzu, Keita| Kishi, Yoji| Ueno, Hideki | |
| Abstract | We report a successful dissection of metastatic posterior thoracic para-aortic lymph node (No. 112aoP) via bilateral thoracoscopic surgery. With the anesthetized patient (a 73-year-old Japanese woman) in the prone position, two working ports were inserted for the left-side approach, and artificial pneumothorax was created. Thoracoscopic examination revealed a swollen LN posterior to the descending aorta. Fat and metastatic LNs posterior to the aorta were dissected from the aortic arch level to the diaphragm while preserving intercostal arteries. For the right-side approach, two working ports were inserted and a routine thoracoscopic esophagec-tomy was performed. Gastric conduit reconstruction was achieved laparoscopically. Operation time for the left thoracic procedure: 54 min; estimated blood loss: almost none. No recurrence was detected 24 months post-operatively. There are several surgical options for approaching No. 112aoP, including transhiatal, left thora-cotomy, and thoracoscopy. Although a wide dissection of the posterior thoracic para-aortic area has not been reported, it may be feasible and safe if the artery of Adamkiewicz and intercostal arteries are preserved. A min-imally invasive bilateral thoracoscopic approach for a thoracoscopic esophagectomy is safe and useful for esophageal cancer patients with solitary No. 112aoP metastasis. |
| Keywords | bilateral approach posterior thoracic para-aortic lymph node thoracoscopic esophagectomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 521 |
| End Page | 524 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361872 |
| Web of Science KeyUT | 000601203600008 |
| NAID | 120006948950 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Oyama, Takanori| Noda, Takuo| Washio, Kana| Shimada, Akira| |
| Keywords | growing teratoma syndrome immature teratoma ovarian tumor pediatric |
| Published Date | 2020-09-18 |
| Publication Title | Medicine |
| Volume | volume99 |
| Issue | issue38 |
| Publisher | Lippincott, Williams & Wilkins |
| Start Page | e22297 |
| ISSN | 0025-7974 |
| NCID | AA00728867 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 the Author(s). |
| File Version | publisher |
| PubMed ID | 32957389 |
| DOI | 10.1097/MD.0000000000022297 |
| Web of Science KeyUT | 000579298600086 |
| Related Url | isVersionOf https://doi.org/10.1097/MD.0000000000022297 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Taniguchi, Kohei| Takada, Shinichi| Omori, Masako| Igawa, Takuro| Nishimura, Midori Filiz| Morito, Toshiaki| Ichimura, Kouichi| Yoshino, Tadashi| |
| Published Date | 2020-07-22 |
| Publication Title | PLoS ONE |
| Volume | volume15 |
| Issue | issue7 |
| Publisher | Public Library of Science |
| Start Page | e0235790 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Taniguchi et al. |
| File Version | publisher |
| PubMed ID | 32697770 |
| DOI | 10.1371/journal.pone.0235790 |
| Web of Science KeyUT | 000575905100006 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0235790 |
| FullText URL | J_Invest_Med_HIgh_Inpact_Case_Rep_8.pdf |
|---|---|
| Author | Matsuo, Toshihiko| Shimizu, Takehiro| Tanaka, Takehiro| Yamamoto, Akira| Takasuka, Hiroki| |
| Keywords | adult T-cell leukemia/lymphoma vitreous opacity vitrectomy aqueous hypopyon aqueous tap cytology pathology Japanese literature review immunostaining |
| Published Date | 2020-10-20 |
| Publication Title | Journal of Investigative Medicine High Impact Case Reports |
| Volume | volume8 |
| Publisher | SAGE Publications |
| Start Page | 2324709620966843 |
| ISSN | 2324-7096 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 American Federation for Medical Research |
| File Version | publisher |
| DOI | 10.1177/2324709620966843 |
| Related Url | isVersionOf https://doi.org/10.1177/2324709620966843 |
| JaLCDOI | 10.18926/AMO/60803 |
|---|---|
| FullText URL | 74_5_427.pdf |
| Author | Hiraoka, Tomohiro| Senoo, Haruka| Yamazaki, Yuka| Suenobu, Kosaku| Tsukahara, Hirokazu| |
| Abstract | Polydactyly is one of the most common foot congenital anomalies. It is often detected immediately after birth, but the diagnosis can sometimes be delayed if the symptoms are less evident. A 2-year-old girl with a complaint of recurrent bleeding from the right toenail was diagnosed with foot polydactyly. She underwent corrective surgery, and her family was satisfied with the outcome. Although the diagnosis of polydactyly may be difficult in cases with minor nail problems, further radiographic evaluation will be needed for the improvement of the patient’s quality of life. |
| Keywords | polydactyly hyperdactyly hexadactyly |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 427 |
| End Page | 429 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106699 |
| Web of Science KeyUT | 000581970100008 |
| NAID | 120006892929 |
| JaLCDOI | 10.18926/AMO/60799 |
|---|---|
| FullText URL | 74_5_401.pdf |
| Author | Tsukioki, Takahiro| Shien, Tadahiko| Ohtani, Yusuke| Fujihara, Miwa| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| |
| Abstract | Differentiated thyroid carcinoma (DTC) in juvenile patients is often an extensive and aggressive disease with a high frequency of recurrence. However, the prognosis is excellent, with a low mortality rate even when advanced disease is present, although prognostic factors and treatment strategy remain uncertain. Between April 2004 and March 2017, 33 juvenile patients (< 30 years old) were diagnosed with DTC and treated at our institution. We retrospectively investigated prognosis and factors including sex, reason for discovery, treatment, pathological factors and treatment progress to clarify the risk factors. All patients underwent curative surgical treatment. Pathologically, lymph node metastasis was identified in 25 patients (75%). Thirteen patients (39%) had bilateral cervical metastasis. In addition, 9 (27%) had more than 10 metastatic lymph nodes. The 2 patients with more than 20 metastatic lymph nodes were treated with radioactive iodine (RAI). Five patients (15%) had local recurrences and received surgery. There have been no further recurrences or deaths. However, no factors were determined to significantly predict the recurrence of juvenile DTC. Local recurrent disease was treated with surgery and/or RAI until remission, and survival was excellent in juvenile DTC. |
| Keywords | differentiated thyroid carcinoma juvenile children |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 401 |
| End Page | 406 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106695 |
| Web of Science KeyUT | 000581970100004 |
| NAID | 120006892925 |
| JaLCDOI | 10.18926/AMO/60796 |
|---|---|
| FullText URL | 74_5_371.pdf |
| Author | Makimoto, Go| Ohashi, Kadoaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Abstract | The prognosis of advanced non-small cell lung cancer (NSCLC) patients has improved in recent decades, especially for patients with an oncogenic driver mutation. Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are effective for patients with the echinoderm microtubule-associated protein-like 4-ALK fusion gene. Several ALK-TKIs have been established: the first-generation ALK-TKI, crizotinib; second-generation ALK-TKIs, alectinib and ceritinib; and third-generation ALK-TKI, lorlatinib. Some ALK-TKIs are effective for tumors that are resistant to other ALK-TKIs; however, as is known in epidermal growth factor receptormutant lung cancer, tumor resistance is inevitable. ALK-positive NSCLCs acquire resistance via various mechanisms, making it a heterogeneous disease. Therefore, it is necessary to develop next-generation treatment strategies, such as the use of next-generation ALK-TKIs for secondary mutations, or combination therapies with ALK-TKIs and other TKIs. In this review, we summarize the development and use of ALK-TKIs, prior pivotal clinical trials, and resistance mechanisms. |
| Keywords | lung cancer anaplastic lymphoma kinase tyrosine kinase inhibitors resistance mechanism |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 371 |
| End Page | 379 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106692 |
| Web of Science KeyUT | 000581970100001 |
| NAID | 120006892922 |
