result 404 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sera, Yasuaki| Ueda, Takahiro| Adachi, Hiroto| Ichioka, Masanori| |
| Keywords | unconventional superconductivity pairing symmetry vortex states non-magnetic impurity scattering |
| Published Date | 2020-01-18 |
| Publication Title | Symmetry |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | MDPI |
| Start Page | 175 |
| ISSN | 2073-8994 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| DOI | 10.3390/sym12010175 |
| Web of Science KeyUT | 000516823700175 |
| Related Url | isVersionOf https://doi.org/10.3390/sym12010175 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kato, Koji| Shinoda, Toshiyuki| Nagao, Ryo| Akimoto, Seiji| Suzuki, Takehiro| Dohmae, Naoshi| Chen, Min| Allakhverdiev, Suleyman I.| Shen, Jian-Ren| Akita, Fusamichi| Miyazaki, Naoyuki| Tomo, Tatsuya| |
| Published Date | 2020-01-13 |
| Publication Title | Nature Communications |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 238 |
| ISSN | 2041-1723 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 31932639 |
| DOI | 10.1038/s41467-019-13898-5 |
| Web of Science KeyUT | 000511916800016 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-019-13898-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Oltmanns, Anne| Hoepfner, Lara| Scholz, Martin| Zinzius, Karen| Schulze, Stefan| Hippler, Michael| |
| Keywords | C. reinhardtii N-glycosylation xylosyltransferase fucosyltransferase mass spectrometry post-translational modification secretory pathway |
| Published Date | 2020-01-15 |
| Publication Title | Frontiers in Plant Science |
| Volume | volume10 |
| Publisher | Frontiers Media |
| Start Page | 1686 |
| ISSN | 1664-462X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Oltmanns, Hoepfner, Scholz, Zinzius, Schulze and Hippler. |
| File Version | publisher |
| PubMed ID | 32010168 |
| DOI | 10.3389/fpls.2019.01686 |
| Web of Science KeyUT | 000510647400001 |
| Related Url | isVersionOf https://doi.org/10.3389/fpls.2019.01686 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yu, Yinghua| Huber, Laurentius| Yang, Jiajia| Jangraw, David C.| Handwerker, Daniel A.| Molfese, Peter J.| Chen, Gang| Ejima, Yoshimichi| Wu, Jinglong| Bandettini, Peter A.| |
| Published Date | 2019-05-01 |
| Publication Title | Science Advances |
| Volume | volume5 |
| Issue | issue5 |
| Publisher | American Association for the Advancement of Science |
| Start Page | eaav9053 |
| ISSN | 2375-2548 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors |
| File Version | publisher |
| PubMed ID | 31106273 |
| DOI | 10.1126/sciadv.aav9053 |
| Web of Science KeyUT | 000470125000084 |
| Related Url | isVersionOf https://doi.org/10.1126/sciadv.aav9053 |
| JaLCDOI | 10.18926/OER/58070 |
|---|---|
| Title Alternative | The Development Strategies of Poland and the Engine of Polish Economic Growth |
| FullText URL | oer_051_2-3_015_037.pdf |
| Author | Taguchi, Masahiro| Okazaki, Taku| |
| Abstract | In this paper, authors analyze the changes in the national development strategies of the Polish government since the First World War, the state investment that became the driving force of economic development, the trends and positions of foreign capital, and the changes in the economic environment surrounding the Polish economy. In the Second Republic, economic liberalism was a widely supported philosophy in the business world and academic society. However, in order to support very weak economic fundamentals, the government seized the key industry and tried to rebuild the economy. Although foreign capital played a very important role in economic development, Polish people’s distrust in foreign capital was strong. After the Great Depression, the Central Industrial District（ CUP） was built under the leadership of the government. However, with the outbreak of World War II, the formation of a strong core industrial base was suspended. After the Second World War, the government initially aimed to build a Peoples Democracy system based on pluralism. However, when the Cold War sharpened, rapid industrialization and collectivization of agriculture were forced. The Stalinist economic development strategy failed in a few years. Nevertheless, from the end of the 1950s, mining development and industrialization based on the mechanical and chemical industries were carried out again. This industrialization of capital goods sector-oriented production has distorted the people’s consumer life. However, in the long run, it cannot be denied that the industrialization of that time became the basis for the formation of the wide promising fields of the Polish industry. Since 1970, an open economic strategy has been adopted. Modernization was attempted by introducing licenses from the west. However, new investments did not lead to expansion of export, and cumulative debt increased. During the economic crisis, the“ Solidarity” movement quickly grew into a national movement, but this did not lead to a fundamental economic system change. Economic reform was also attempted in the 1980s. However, the socialist economic system was unable to adapt to the new global economic system driven by innovation. The inflexible system lost its growth potential. After the collapse of socialist system in 1989, radical liberalization policies drastically improved economic imbalances, and the economic policy enabled high growth. During the transition period, foreign capital greatly contributed to growth. The automobile industry is a good example. This industry is associated with wide parts production. Many domestic intermediate goods manufacturers increased their orders, and their technical capabilities were rapidly improved through the guidance of foreign capital. In addition, export has improved significantly due to the expansion of production by foreign-affiliated companies. In contrast to the Second Republic, foreign capital played a major role in nurturing domestic industries. By the end of the 1990s, the Russian economy had had no effect on the Polish economy. At the transition period, the Polish industry shifted rapidly to the EU. At the same time, since the manufacturing field was the foundation of Polish growth, the impact of the 2007 global financial crisis wasn’t serious. Not only that, Poland maintained positive growth in 2008 as most countries in Europe fell into negative Currently, low-wage, low-value-added production based on FDI inflows and abundant labor force is the driving force for growth. In the medium and long term, the Polish economy cannot grow if it stays in the current subcontract production status of industrialized countries. The key to Poland’s escape from the “middle-income trap” is how to develop“ new Polish companies” that produce high-value-added products and services under global competition. |
| Publication Title | Okayama Economic Review |
| Published Date | 2020-03-19 |
| Volume | volume51 |
| Issue | issue2-3 |
| Start Page | 15 |
| End Page | 37 |
| ISSN | 2433-4146 |
| language | Japanese |
| Copyright Holders | Copyright © 2020 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120006812123 |
| Title Alternative | Mathematical analysis of copy number variation of 2 μ-based plasmids in yeast cells |
|---|---|
| FullText URL | srfa_109_007_011.pdf |
| Author | Saeki, Nozomu| Moriya, Hisao| |
| Abstract | Plasmids with the 2 μ plasmid origin are commonly-used in the genetic engineering of the budding yeast Saccharomyces cerevisiae. Intracellular copy numbers of 2 μ plasmids are different depending on the genes inserted into the plasmids. This difference is thought to occur from the difference in the growth efficiency （fitness） produced by the positive- and negative-selection biases of genes inserted in the plasmid. In this study, we made a mathematical model based on this assumption. Computational simulations of the model validated that copy numbers of the plasmids are rapidly settled depending on the fitness created by the gene on the plasmid. The copy number of a plasmid only contains a bias to keep the plasmid in a single copy became average 20copies per cell when the plasmid is randomly distributed, suggesting that no positive distribution mechanism is required for a plasmid to become multicopy. |
| Keywords | yeast 2 μ plasmid mathematical model |
| Publication Title | Scientific Reports of the Faculty of Agriculture, Okayama University |
| Published Date | 2020-02-01 |
| Volume | volume109 |
| Start Page | 7 |
| End Page | 11 |
| ISSN | 2186-7755 |
| language | Japanese |
| File Version | publisher |
| FullText URL | SR9_1_5186.pdf |
|---|---|
| Author | Sumi, Tomonari| Koga, Kenichiro| |
| Published Date | 2019-3-26 |
| Publication Title | Scientific Reports |
| Volume | volume9 |
| Publisher | Nature Publishing Group |
| Start Page | 5186 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2019 |
| File Version | publisher |
| PubMed ID | 30914684 |
| DOI | 10.1038/s41598-019-41518-1 |
| Web of Science KeyUT | 000462298600073 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-41518-1 |
| FullText URL | SR9_1_8866.pdf |
|---|---|
| Author | Abe-Kanoh, Naomi| Kunisue, Narumi| Myojin, Takumi| Chino, Ayako| Munemasa, Shintaro| Murata, Yoshiyuki| Satoh, Ayano| Moriya, Hisao| Nakamura, Yoshimasa| |
| Published Date | 2019-6-20 |
| Publication Title | Scientific Reports |
| Volume | volume9 |
| Publisher | Nature Publishing Group |
| Start Page | 8866 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2019 |
| File Version | publisher |
| PubMed ID | 31222108 |
| DOI | 10.1038/s41598-019-45248-2 |
| Web of Science KeyUT | 000472136900040 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-45248-2 |
| FullText URL | AmeMineral_103_8_1271.pdf |
|---|---|
| Author | Gomi, Hitoshi| Fei, Yingwei| Yoshino, Takashi| |
| Keywords | FeHx ferromagnetism chemical disorder equation of states KKR-CPA |
| Published Date | 2018-08-01 |
| Publication Title | American Mineralogist |
| Volume | volume103 |
| Issue | issue8 |
| Publisher | Mineralogical Society of America |
| Start Page | 1271 |
| End Page | 1281 |
| ISSN | 0003-004X |
| NCID | AA00521712 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.2138/am-2018-6295 |
| Web of Science KeyUT | 000440466900009 |
| Related Url | isVersionOf https://doi.org/10.2138/am-2018-6295 |
| FullText URL | FES_6_217.pdf |
|---|---|
| Author | Gomi, Hitoshi| Yoshino, Takashi| |
| Keywords | band structure density of states electrical resistivity thermal conductivity Linde's rule KKR-CPA |
| Published Date | 2018-11-29 |
| Publication Title | Frontiers in Earth Science |
| Volume | volume6 |
| Publisher | FRONTIERS MEDIA SA |
| Start Page | 217 |
| ISSN | 2296-6463 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright © 2018 Gomi and Yoshino. |
| File Version | publisher |
| DOI | 10.3389/feart.2018.00217 |
| Web of Science KeyUT | 000454098500001 |
| Related Url | isVersionOf https://doi.org/10.3389/feart.2018.00217 |
| FullText URL | JGPP_2019.pdf |
|---|---|
| Author | Ichinose, Yuki| Tasaka, Yousuke| Yamamoto, Satoru| Inoue, Yuko| Takata, Motohiro| Nakatsu, Yukiko| Taguchi, Fumiko| Yamamoto, Mikihiro| Toyoda, Kazuhiro| Noutoshi, Yoshiteru| Matsui, Hidenori| |
| Keywords | AHL PsyI PsyR Quorum sensing |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Journal of General Plant Pathology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10327-019-00893-3.| |
| Published Date | 2019-11-11 |
| Publication Title | Journal of General Plant Pathology |
| Volume | volume86 |
| Publisher | Springer |
| Start Page | 124 |
| End Page | 133 |
| ISSN | 13452630 |
| NCID | AA11449093 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1007/s10327-019-00893-3 |
| Web of Science KeyUT | 000495768600001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10327-019-00893-3 |
| FullText URL | DevBiol_452_104.pdf |
|---|---|
| Author | Saito, Nanami| Nishimura, Koki| Makanae, Aki| Satoh, Akira| |
| Keywords | Blastema induction Bmp Fgf Gill regeneration Nerve Organ regeneration |
| Published Date | 2019-08-15 |
| Publication Title | Developmental Biology |
| Volume | volume452 |
| Publisher | Elsevier |
| Start Page | 104 |
| End Page | 113 |
| ISSN | 00121606 |
| NCID | AA00627848 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. Published by Elsevier Inc. |
| File Version | publisher |
| PubMed ID | 31034835 |
| DOI | 10.1016/j.ydbio.2019.04.011 |
| Web of Science KeyUT | 000473375100005 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ydbio.2019.04.011 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hashimoto, Hideki| Muramatsu, Yusuke| Nishina, Yuta| Asoh, Hidetaka| |
| Keywords | Graphite Graphene Graphene oxide Electrochemical exfoliation Anode Bipolar electrochemistry |
| Published Date | 2019-07-31 |
| Publication Title | Electrochemistry Communications |
| Volume | volume104 |
| Publisher | Elsevier |
| Start Page | 106475 |
| ISSN | 13882481 |
| NCID | AA11324699 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. Published by Elsevier B.V. |
| File Version | publisher |
| DOI | 10.1016/j.elecom.2019.06.001 |
| Web of Science KeyUT | 000480667900012 |
| Related Url | isVersionOf https://doi.org/10.1016/j.elecom.2019.06.001 |
| FullText URL | SciRep_9_1_5186.pdf |
|---|---|
| Author | Sumi, Tomonari| Koga, Kenichiro| |
| Published Date | 2019-03 |
| Publication Title | Scientific Reports |
| Volume | volume9 |
| Issue | issue1 |
| Publisher | Nature Publishing Group |
| Start Page | 5186 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 30914684 |
| DOI | 10.1038/s41598-019-41518-1 |
| Web of Science KeyUT | 000462298600073 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-41518-1 |
| JaLCDOI | 10.18926/AMO/56937 |
|---|---|
| FullText URL | 73_4_349.pdf |
| Author | Isozaki, Hiroshi| Yamamoto, Yasuhisa| Murakami, Shigeki| Matsumoto, Sasau| Takama, Takehiro| |
| Abstract | To clarify the surgical outcomes of breast cancer patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) by core needle biopsy (CNB) (abbreviated as CNBDCIS), we retrospectively analyzed the cases of 131 patients with CNBDCIS who underwent surgery at Oomoto Hospital (32 total mastectomies, 99 conservative mastectomies). Our analysis of underestimation and predictors of invasive breast cancer of CNBDCIS revealed that the underestimation rate of CNBDCIS was 40.5% (53/131). A logistic regression analysis revealed that palpable tumors (yes to no, odds ratio [OR] 3.25), mammography (MMG) category group (category 4 or 5 to categories 1 , 2, or 3, OR 4.69) and MMG microcalcifications (no to yes, OR 0.24) were significant predictive factors for CNBDCIS invasion. In our analysis of the predictors of positive margins during CNBDCIS surgery, 36 (27.5%) of the 131 patients had positive margins after postoperative pathological examination. A logistic regression analysis revealed that the operative procedure (conservative surgery to total mastectomy, OR 21.4) and MMG microcalcifications (yes to no, OR 3.35) were significant factors related to positive margins during CNBDCIS surgery. Thus, MMG microcalcifications are a negative predictor of upgrading of CNBDCIS and a positive predictor of positive surgical margins for CNBDCIS. |
| Keywords | ductal carcinoma in situ core needle biopsy underestimation positive margins microcalcifications on mammography |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 349 |
| End Page | 356 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439958 |
| JaLCDOI | 10.18926/AMO/56933 |
|---|---|
| FullText URL | 73_4_315.pdf |
| Author | Ono, Shintaro| Nakayama, Masaaki| Tachibana, Masato| Abu Saleh Muhammad Shahriar| Heling, Wang| Takashiba, Shogo| Ohara, Naoya| |
| Abstract | The periodontal pathogen Porphyromonas gingivalis shows colonial pigmentation on blood agar and produces gingipains (Kgp, RgpA, and RgpB), cysteine proteases involved in an organism’s virulence and pigmentation. We showed previously that deletion of the PGN_0300 gene abolished the pigmentation activity and reduced the proteolytic activity of gingipains. The role of the PGN_0297 gene, which consists of an operon with the PGN_0300 gene, is unclear. Herein we examined the effect of PGN_0297 gene deletion on the pigmentation and proteolytic activities and transcriptional levels of gingipains. A PGN_0297 gene deletion mutant (ΔPGN_0297) did not exhibit the pigmentation. The proteolytic activity of the gingipains was decreased in the culture supernatant and on the cell surface of ΔPGN_0297. The mutant ΔPGN_0297 failed to attenuate Akt phosphorylation at Thr308 and Ser473, but both phosphorylations were attenuated in the wild-type and its complementation strain. The deletion of PGN_0297 gene did not substantially affect the transcriptional levels of the gingipain genes kgp, rgpA, and rgpB. Taken together, these results indicate that PGN_0297 is closely involved in the secretion and maturation of gingipains. |
| Keywords | periodontitis Porphyromonas gingivalis gingipain C-terminal domain secretion system |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 315 |
| End Page | 323 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439954 |
| JaLCDOI | 10.18926/OER/56909 |
|---|---|
| Title Alternative | The Revolutionary Forces in Marx’s Theory and Marxism : Development? or Distortion? |
| FullText URL | oer_051_1_001_018.pdf |
| Author | Ota , Yoshiki| |
| Abstract | 1. Diffusion of Marxism and inflation of the concept “proletariat” The concept of “proletariat” is the central concept of Marxism. However, its content varies according to times and regions. For Marx and Engels, proletarias are workers who work in the capitalist large industries, they overthrow the rule of capitalists through the revolution and are the subjects of the construction of society in the future. Kautsky put workers in small factories and small farmers into the category of proletariat. Lenin overestimated capitalist development in Russia and included farmers without horses into proletariat. In Mao Zedong, agricultural workers, rumpen, handmade workers, peasants, clerks and peddlers are also allowed to participate in the revolution. The concept of proletariat is inflated. As the region moves away from the center of the world system, the scope of participants in the revolution has been expanded. 2. “Proletariat” in Marx’s view on social development In Marx, proletariat is given a privileged position as a revolutionary subject in the capitalist society. In the “formulation” of historical materialism, modern bourgeois society is given a privileged position in human history. Proletariat is privileged in dual sense. In this formulation, there is no social antagonism in the future society that Marx believes. This future society should be called a “community without law and state”. It is recognized that the development of capitalist production increases the number of workers and the ordinary electoral system increases possibilities of acquiring a working-class regime. Still, Capital insists that the revolution is inevitable. Marx and Engels never abandoned “revolutionism” throughout their lives. 3. Marx’s revolutionary strategy and British working class For Marx and Engels, England is a typical country of capitalistic development, giving models to other countries.However, the English working class in the mid-19th century was not “revolutionary”. The English labor movement during this period had been internalized under the guidance of the “labor aristocrat”. Working class was integrated as “nation”. While cooperating with the reformists politically, Marx was argueing revolutionism in scientific books. While cooperating with the reformists politically, Marx was advocating revolutionism in Capital. In modern bourgeois society, it is usual that labor classes are integrated into a system as “nation” and labor movement is to become reformistic, but Marx could not analyze this situation as a problem of upper structure of capitalism in general. In England Marx cooperated with the reformist labor movement, but could not abandon his revolutionism. 4. Reform Movement and Revolutionism: German Revisionism Controversy and Russian Party Organization Controversy At the German Social Democratic Party, there was coexistence of reformistic practice and ideology of revolutionism. Kautsky was a personal expression of this coexistence. He adhered to revolutionism, but acknowledged that socialist consciousness was brought into labor movement from the outside historically. Bernstein claimed that revolutionism is an obstacle to workers’ reform movement. In the controversy concerning the organization of the Russian Social Democratic Party, from the standpoint of revolutionalism, Lenin argued that “external injection” is necessary because the workers’ reform movement and the revolutionary socialist movement are not directly connected. The revolutionary forces are not necessarily the product of the capitalist big industry. Those who have abilities to resist the capitalist system, they can participate in the socialist revolution through the “external injection” of the revolutionary party. It can be said that the logic of “external injection” made it possible to disseminate Marxism to the semi-periphery and periphery. 5. Conclusion The Marxist revolution theory is understood as the theory of “revolution of developed countryies”. This is because it assumes the proletariat produced by the capitalist big industry as the revolutionary subject. In the case of Marx, its understanding is correct. However, the successful acquisition of the regime by the Marxist was in “backward countries”. It can be said that the key to solving this paradox was in the unreality of the concept of “proletariat” at the core of Marx’s revolutionism. Marx’s “proletariat” has no realities in the working class in center of modern capitalit world system （“developed capitalist countries”）. On the other hand, various anti-systemic forces were formed as a revolutionary subject entity or “proletariat” by “external injection” of the revolutionary parties in semi-periphery and periphery （the “backward areas”）. Rosa Luxemburg called as “clique management （Cliquenwirtschaft）” the regime that such forces could aquire. Under the “clique management” system, people remained in the object of governance and never became the subject. |
| Publication Title | Okayama Economic Review |
| Published Date | 2019-07-16 |
| Volume | volume51 |
| Issue | issue1 |
| Start Page | 1 |
| End Page | 18 |
| ISSN | 2433-4146 |
| language | Japanese |
| Copyright Holders | Copyright © 2019 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120006652408 |
| JaLCDOI | 10.18926/AMO/56457 |
|---|---|
| FullText URL | 73_1_43.pdf |
| Author | Ikeda, Ailee| Takaki, Akinobu| Yasunaka, Tetsuya| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Onishi, Hideki| Ikeda, Fusao| Shiraha, Hidenori| Yoshida, Kazuhiro| Kuise, Takashi| Nobuoka, Daisuke| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Fujiwara, Toshiyoshi| Okada, Hiroyuki| |
| Abstract | Post-orthotopic liver transplantation (OLT) hepatitis B recurrence is well-controlled with a nucleos(t)ide analogue and hepatitis B immunoglobulin (HBIG) combination, but the high cost and the potential risk of unknown infection associated with HBIG remain unresolved issues. Low-cost recombinant hepatitis B virus (HBV) vaccine administration is a potential solution to these problems. We retrospectively analyzed the rate and predictive factors of HBV vaccine success in 49 post-OLT patients: liver cirrhosis-type B (LC-B), n=28 patients; acute liver failure-type B (ALF-B), n=8; and non-HBV-related end-stage liver disease (non-B ESLD) who received a liver from anti-hepatitis B core antibody-positive donors, n=13. A positive anti-hepatitis B surface antibody response was achieved in 29% (8/28) of the LC-B group, 88% (7/8) of the ALF-B group, and 44% (4/9) of the adult non-B ESLD group. All four non-B ESLD infants showed vaccine success. The predictive factors for a good response in LC-B were young age, marital donor, and high donor age. ALF-B and non-B ESLD infants are thus good vaccination candidates. LC-B patients with marital donors are also good candidates, perhaps because the donated liver maintains an efficient immune memory to HBV, as the donors had already been infected in adulthood and showed adequate anti-HBV immune responses. |
| Keywords | acute liver failure hepatitis B hepatitis B vaccine liver cirrhosis liver transplantation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 41 |
| End Page | 50 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820053 |
| FullText URL | PhysRevB_97_134507.pdf |
|---|---|
| Author | Tanaka, Kenta K.| Ichioka, Masanori| Onari, Seiichiro| |
| Note | This is an article published by American Physical Society| |
| Published Date | 2018-04-10 |
| Publication Title | Physical Review B |
| Volume | volume97 |
| Publisher | American Physical Society |
| Start Page | 134507 |
| ISSN | 2469-9950 |
| NCID | AA11187113 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| DOI | 10.1103/PhysRevB.97.134507 |
| Web of Science KeyUT | 000429524500002 |
| Related Url | isVersionOf https://doi.org/10.1103/PhysRevB.97.134507 |
| JaLCDOI | 10.18926/AMO/56178 |
|---|---|
| FullText URL | 72_4_401.pdf |
| Author | Wada, Nozomu| Ikeda, Fusao| Mori, Chizuru| Takaguchi, Koichi| Fujioka, Shin-ichi| Kobashi, Haruhiko| Morimoto, Yoichi| Kariyama, Kazuya| Sakaguchi, Kosaku| Hashimoto, Noriaki| Moriya, Akio| Kawaguchi, Mitsuhiko| Miyatake, Hirokazu| Hagihara, Hiroaki| Kubota, Junichi| Takayama, Hiroki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Takaki, Akinobu| Iwasaki, Yoshiaki| Okada, Hiroyuki| |
| Abstract | Daclatasvir (DCV) + asunaprevir (ASV) combination therapy has become available for patients with hepatitis C virus (HCV) serogroup 1 infection. We studied the efficacy of this therapy by focusing on the factors associated with sustained virological responses (SVR) including resistance-associated variants (RAVs) and mixed infection of different HCV genotypes. We enrolled 951 HCV serogroup 1-positive patients who received this combination therapy at our hospital or affiliated hospitals. The presence of RAVs in non-structural (NS) regions 3 and 5A was analyzed by direct sequencing. HCV genotypes were determined by PCR with genotype-specific primers targeting HCV core and NS5B regions. SVR was achieved in 91.1% of patients. Female sex, age > 70 years, and RAVs were significantly associated with non-SVR (p<0.01 for all). Propensity score-matching results among the patients without RAVs regarding sex, age, and fibrosis revealed that mixed HCV infection determined by HCV NS5B genotyping showed significantly lower SVR rates than 1B-mono infection (p=0.02). Female sex and RAVs were significant factors associated with treatment failure of this combination therapy for patients with HCV serogroup 1 infection. Mixed HCV infection other than 1B-mono infection would be useful for predicting treatment failure. |
| Keywords | mixed genotype daclatasvir asunaprevir HCV serogrouping 1 infection |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-08 |
| Volume | volume72 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 401 |
| End Page | 406 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30140089 |
