result 5811 件
| Author | Nakao, Satoshi| Komagoe, Keiko| Inoue, Tsuyoshi| Katsu, Takashi| |
|---|---|
| Published Date | 2011-01 |
| Publication Title | Biochimica et Biophysica Acta (BBA) - Biomembranes |
| Volume | volume1808 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Motose, Hiroyasu| Hamada, Takahiro| Yoshimoto, Kaori| Murata, Takashi| Hasebe, Mitsuyasu| Watanabe, Yuichiro| Hashimoto, Takashi| Sakai, Tatsuya| Takahashi, Taku| |
|---|---|
| Published Date | 2011-09 |
| Publication Title | The Plant Journal |
| Volume | volume67 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Tetsunaga, Tomonori| Furumatsu, Takayuki| Abe, Nobuhiro| Nishida, Keiichiro| Naruse, Keiji| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2009-09-18 |
| Publication Title | Journal of Biomechanics |
| Volume | volume42 |
| Issue | issue13 |
| Content Type | Journal Article |
| Author | Furumatsu, Takayuki| Ozaki, Toshifumi| Asahara, Hiroshi| |
|---|---|
| Published Date | 2009-05 |
| Publication Title | The International Journal of Biochemistry & Cell Biology |
| Volume | volume41 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Furumatsu, Takayuki| Shukunami, Chisa| Amemiya-Kudo, Michiyo| Shimano, Hitoshi| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2010-01 |
| Publication Title | The International Journal of Biochemistry & Cell Biology |
| Volume | volume42 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Furumatsu, Takayuki| Hachioji, Motomi| Saiga, Kenta| Takata, Naoki| Yokoyama, Yusuke| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2010-01-01 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume391 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Saiga, Kenta| Furumatsu, Takayuki| Yoshida, Aki| Masuda, Shin| Takihira, Shota| Abe, Nobuhiro| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2010-11-12 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume402 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kochi, Takeshi| |
|---|---|
| Published Date | 1936-05-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume48 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Ueda, Youki| Mori, Kyoko| Ariumi, Yasuo| Ikeda, Masanori| Kato, Nobuyuki| |
|---|---|
| Published Date | 2011-06-17 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume409 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Miyake, Yoshiaki| Furumatsu, Takayuki| Kubota, Satoshi| Kawata, Kazumi| Ozaki, Toshifumi| Takigawa, Masaharu| |
|---|---|
| Published Date | 2011-06-03 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume409 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Hoen, Yukihiko| |
|---|---|
| Published Date | 1955-02-28 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume66 |
| Issue | issue10 suppl |
| Content Type | Journal Article |
| Author | Akatsuka, Kazuya| Uno, Fumio| Uno, Naomichi| Kuroki, Ikuyo| Yamanishi, Shigeki| Tominaga, Akira| Tsutsui, Kiyoshi| Nii, Shiro| |
|---|---|
| Published Date | 1981-02-28 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume93 |
| Issue | issue1-2 suppl |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/46850 |
|---|---|
| FullText URL | 65_4_247.pdf |
| Author | Watanabe, Naomi| Shikata, Kenichi| Shikata, Yasushi| Sarai, Kei| Omori, Kazuyoshi| Kodera, Ryo| Sato, Chikage| Wada, Jun| Makino, Hirofumi| |
| Abstract | Inflammatory processes are involved in the pathogenesis of diabetic nephropathy. The aim of this study was to clarify the role of mitogen-activated protein kinase (MAPK) pathways for induction of intercellular adhesion molecule-1 (ICAM-1) expression in glomerular endothelial cells under diabetic conditions. We examined the expression of ICAM-1 in the kidneys of experimental diabetic rats. Human glomerular endothelial cells (GE cells) were exposed to normal glucose concentration, high glucose concentration (HG), or high mannitol concentration (HM), and then the expression of the ICAM-1 protein and the phosphorylation of the 3 subfamilies of mitogen-activated protein kinase (MAPK) were determined using Western blot analysis. Next, to evaluate the involvement of MAPKs in HG- or HM-induced ICAM-1 expression, we preincubated GE cells with the inhibitors for ERK, p38 or JNK 1h prior to the application of glucose or mannitol. Expression of ICAM-1 was increased in the glomeruli of diabetic rats. Both HG and HM induced ICAM-1 expression and phosphorylation of ERK1/2, p38 and JNK in GE cells. Expression of ICAM-1 was significantly attenuated by inhibitors of ERK, p38 and JNK. We conclude that activation of ERK1/2, p38 and JNK cascades may be involved in ICAM-1 expression in glomerular endothelial cells under diabetic conditions. |
| Keywords | diabetic nephropathy ICAM-1 ERK p38 MAPK JNK |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-08 |
| Volume | volume65 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 247 |
| End Page | 257 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21860531 |
| Web of Science KeyUT | 000294236700005 |
| Author | Nishina, Shinichi| |
|---|---|
| Published Date | 2011-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Masumoto, Akio| |
|---|---|
| Published Date | 2011-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Morishima, Tsuneo| |
|---|---|
| Published Date | 2011-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nishie, Manabu| Iwakawa, Kazuhide| Hamano, Ryousuke| Tokunaga, Naoyuki| Tunemitsu, Yousuke| Ootsuka, Shinya| Inagaki, Masaru| Iwagaki, Hiromi| Goubaru, Tomohiro| Fujita, Isao| Murakami, Takako| Tomoda, Jun| |
|---|---|
| Published Date | 2011-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nishie, Manabu| Otsuka, Shinya| Tomoda, Jun| Fujiwara, Keishi| |
|---|---|
| Published Date | 2011-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nasu, Yasutomo| |
|---|---|
| Published Date | 2011-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kuroda, Shinji| Fujiwara, Toshiya| Shirakawa, Yasuhiro| Yamasaki, Yasumoto| Yano, Syuya| Uno, Futoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Watanabe, Yuichi| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2011-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue2 |
| Content Type | Journal Article |
