result 23443 件
| JaLCDOI | 10.18926/15119 |
|---|---|
| Title Alternative | 気管支喘息患者の気管支肺胞細胞からのヒスタミンとロイコトリエンC4遊離 ―アトピー性喘息におけるヒスタミンの役割について― |
| FullText URL | 066_014_020.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | To clarify the main humoral triggering factor (histamine and/or leukotriene) of the early stage of asthma attacks, the release of histamine and leukotriene C4 (LTC4) from bronchoalveolar lavage (BAL) cells stimulated with Ca ionophore A23187 was examined in 7 patients with atopic asthma, and the results were compared to those in 7 nonatopic asthma patients. 1. The proportion of BAL basophilic cells was significantly higher in atopic patients than in nonatopic patients (p<0.05). 2. The content of histamine in BAL fluid was significantly higher in atopic (2.3mcg/mℓ) comparted to that in nonatopic patients (0mcg/mℓ)(p<0.001). The content of LTC4 was high in nonatopic (2.4ng/mℓ) than in atopic patients (0.5ng/ mℓ), however, this was not significant. 3. The release of histamine from BAL cells was 32.6% in atopic and 0% in nonatopic patients, and this was significant (p<0.001). The release of LTC4 from BAL cells was significantly higher in nonatopic (11.3ng/10(6)cell) than in atopic (3.5ng/10(6)cell)(p<0.02). The results demonstrate that histamine play more important role in atopic patients as a main triggering factor of attacks than LTC4. In contrast, in nonatopic patients, LTC4 is more predominant than histamine during early stage of asthma attacks. |
| Keywords | Histamine LTC4 BAL cells atopic asthma |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 14 |
| End Page | 20 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307251 |
| JaLCDOI | 10.18926/15118 |
|---|---|
| Title Alternative | ステロイド依存性重症難治性気管支喘息患者の血清コルチゾールに対する温泉療法の影響 |
| FullText URL | 066_008_013.pdf |
| Author | Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| |
| Abstract | Serum cortisol levels before and after spa therapy were compared in 30 patients with steroid-dependent intractable asthma (SDIA) in relation to clinical asthma types. 1. The mean level of serum cortisol in patients with type la-1 asthma was 2.0±0.7mcg/dℓ before spa therapy, and significantly increased to 9.0±3.1mcg/dℓ (p<0.001). The serum cortisol level of patients with type la-2 also significantly increased from 3.3±1.5mcg/dℓ before spa therapy to 5.9±3.1 mcg/dℓ after the therapy (p<0.05). 2. The level of serum cortisol in patients with type Ib increased from 4.0±1.6mcg/dℓ to 7.8±1.4mcg/ dℓ after spa therapy (p<0.001). In contrast, the serum cortisol levels in patients with type II were not significantly different before (2.7±1.3mcg/dℓ) and after spa therapy (3.5±3.0mcg/dℓ). The results showed that an increase in the levels of serum cortisol by spa therapy was more clearly observed in patients with type la-1 asthma compared to that in type la-2 or type Ib, and that, in contrast, the serum cortisol levels in patients with type II asthma did not significantly increase by spa therapy, since their asthma attacks were always severe and chronic in spite of long-term glucocorticoid regimen. |
| Keywords | Serum cortisol level (血清コルチゾール値) SDIA (ステロイド依存性重症難治性気管支喘息) clinical asthma type (気管支喘息臨床病型) spa therapy (温泉療法) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 8 |
| End Page | 13 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307485 |
| JaLCDOI | 10.18926/15117 |
|---|---|
| Title Alternative | ダニ喘息における気道遊走細胞からのヒスタミン遊離の加齢による減少 |
| FullText URL | 066_001_007.pdf |
| Author | Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa| |
| Abstract | Histamine release from bronchoalveolar cells induced by house dust mite (HDm) was compared in patients with atopic asthma sensitive to HDm in relation to age. 1. Total cell number in bronchoalveolar lavage (BAL) fluid was larger in patients over the age of 40 years (9.10×10(6)) than in those aged between 20 and 39 years (6.25×10(6)), however, this was not significant. 2. Number of BAL eosinophils was not significantly different between the two age groups. 3. Number of BAL basophilic cells was significantly higher in younger patients (20-39 years) (1.85±1.03×10(2)/mℓ) than in older patients (40+ years) (0.39±0.24×10(2)/mℓ) (p<0.001). 4. Histamine release from BAL cells induced by HDm was significantly higher in younger patients (38.1±24.8%) than in older patients (0%) (p<0.001). These results suggest that histamine release from BAL cells in patients with HDm allergy decreases with aging. |
| Keywords | Bronchial asthma House dust allergy Histamine release Bronchoalveolar cells |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1995-09 |
| Volume | volume66 |
| Start Page | 1 |
| End Page | 7 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307845 |
| Author | Matsubara, Fumie| lnoue, Taeko| Mifune, Takashi| Tanizaki, Yoshiro| |
|---|---|
| Published Date | 1996-11 |
| Publication Title | 岡大三朝分院研究報告 |
| Volume | volume67 |
| Content Type | Data or Dataset |
| JaLCDOI | 10.18926/OER/15114 |
|---|---|
| FullText URL | 41_1_053_072.pdf |
| Author | 西垣 鳴人| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2009-06-10 |
| Volume | volume41 |
| Issue | issue1 |
| Start Page | 53 |
| End Page | 72 |
| ISSN | 0386-3069 |
| Related Url | http://www.e.okayama-u.ac.jp/~shiryou/gakkaishi.htm |
| language | Japanese |
| Copyright Holders | 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120002307440 |
| JaLCDOI | 10.18926/OER/15113 |
|---|---|
| FullText URL | 41_1_031_052.pdf |
| Author | Matsuda, Yoichi| 郭 琳| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2009-06-10 |
| Volume | volume41 |
| Issue | issue1 |
| Start Page | 31 |
| End Page | 52 |
| ISSN | 0386-3069 |
| Related Url | http://www.e.okayama-u.ac.jp/~shiryou/gakkaishi.htm |
| language | Japanese |
| Copyright Holders | 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120002307458 |
| JaLCDOI | 10.18926/OER/15112 |
|---|---|
| Title Alternative | Study on retirement program of Japanese Companies : Interview for employee's work contribution. |
| FullText URL | 41_1_001_029.pdf |
| Author | Wu, rina| Matsuda, Yoichi| |
| Abstract | This paper examines to what degrees employees' work contribution to Japanese companies is currently reflected in their retirement program, by using interview as research method (July−Dec., 2008 ; on eight companies and two public offices). It also examines the content of the programs, such as social environment surrounding the system, company policies, and problems and solutions involved in the operation, as well as the transition of the system after Meiji era. Major findings include the followings. Firstly despite some changes occurred in the system as a result of diversification of employment types and styles and also alteration of company policies, the system itself will be maintained in the future. Secondly, although many companies modified conventional seniority−based salary systems for a retirement program that reflect employees' work contribution more clearly through an adoption of 'point system' and other measures, they still find some problems in new systems in their operation and practicality. |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2009-06-10 |
| Volume | volume41 |
| Issue | issue1 |
| Start Page | 1 |
| End Page | 29 |
| ISSN | 0386-3069 |
| Related Url | http://www.e.okayama-u.ac.jp/~shiryou/gakkaishi.htm |
| language | Japanese |
| Copyright Holders | 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120002307792 |
| JaLCDOI | 10.18926/15111 |
|---|---|
| FullText URL | 067_134_146.pdf |
| Author | 寺崎 佳代| 山田 修子| 坂本 香須美| |
| Abstract | 私達はロイ看護モデルで事例を看護過程にそって展開することにした｡急性疾患では生命の危険があるものも少なくはなく,早期に治療とフォローが必要とされる｡それに加えて重要なことは患者自身病気に対し,恐怖にも近い不安を持つ｡患者は個人の中にある調節器対処機制と認知器対処機制によって環境の変化に対処していく｡対処した行動が適応行動か非効果的行動かは,四つの適応様式,つまり生理的,自己概念,役割機能,相互依存によって示される｡患者は自分に必要な行動を認知し,様々な環境に適応していかなければならない｡看護婦は効果的なコミュニケーションを用いて急性期の患者の行動をアセスメントし,適応行動か非効果的行動かを判定する｡その結果として四つの適応様式,それぞれに個人的特徴が強く現れる｡成人期の患者は個人の人生目標もあり,人生経験もある｡あるいは治療中に死に至ることもある｡そこで心理,社会的様式のアセスメントは特に個人の背景や価値観を理解した上でされなければならない｡患者の四つの適応様式,各々の適応を促進するために必要な介助を行うことは看護婦の役割であり,その人の健康や生活の質に貢献することができるものである｡ |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 134 |
| End Page | 146 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307386 |
| JaLCDOI | 10.18926/15109 |
|---|---|
| Title Alternative | A case of multiple pancreatic cysts with K-ras point mutation in pure pancreatic juice |
| FullText URL | 067_121_125.pdf |
| Author | Yamamoto, Ryoichi| Ochi, Koji| Matsumura, Naoki| Tanaka, Juntaro| Kato, Tadahiro| Mizushima, Takaaki| Chowdhury Riaz| Harada, Hideo| Hasuoka, Hideaki| Yokota, Satoshi| Tanizaki, Yoshiro| |
| Abstract | 膵癌の早期診断を行うために,最近の進歩の著しい遺伝子診断を用いて,膵液中のK-ras遺伝子の点突然変異の検討がなされている｡われわれは膵液の細胞診は陰性であるが,K-ras遺伝子の点突然変異を認め,膵全体に多発する膵嚢胞の1例を経験した｡本例は悪性であるとの確診が得られないことや切除するとなれば膵全摘となることなどのために,経過観察を行っているが,18カ月後の現在,嚢胞の増大など認めていない｡膵癌の遺伝子診断の文献的考察を含め,報告する｡ |
| Keywords | 膵嚢胞 (pancreatic cyst) 膵液 (pancreatic juice) K-ras遺伝子 (K-ras oncogene) 点突然変異 (point mutation) 細胞診 (cytology) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 121 |
| End Page | 125 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307457 |
| JaLCDOI | 10.18926/15107 |
|---|---|
| Title Alternative | Meteorological Background on the Eastward Propagating Weather System Learned at the 5th Grade of the Primary School - A Report of a Lecture for Bachelor Students of Faculty of Education - |
| FullText URL | 009_083_096.pdf |
| Author | Kato, Kuranoshin| |
| Abstract | 本論文では,小学校第5学年で学習する｢西から東への天気の移り変わり｣に関する気象学的な背景,｢初等理科内容研究①」でのそれに関する講義の内容,講義の効果や今後の課題について検討した｡中緯度大気大循環の基本的システムとしての日々の現象の実態,特に,東進に伴う高低気圧の発達の様子 を捉えさせるために,典型的な事例を用いて気象衛星画像の動画等の観察や地上天気図への記入作業を行わせた｡また,この単元の学習を春や秋以外の事例で行うことの不都合性に関して,低気圧通過後に冬型になる事例や梅雨前線が停滞する事例を検討させた｡広域の雲分布の振る舞いと大気システム･大 気過程との対応,あるいは日本の天気との関連についての相互関係の理解は不十分と見られるような課題は残ったが,高低気圧の発達を示す幾つかの重要な事実を捉える機会となった点は成果だと考える｡ |
| Keywords | 学生や現職教員への気象教育 (Meteorology Educat ion for Bachelor Students or School Teachers) 中緯度の天気系 (Weather Systems in the Middle Latitudes) 日本の気象・気候 (Weather and Climate around Japan) 気象衛星画像や天気図を活用した気象教材 (Teaching Materials using Meteorological Satellite Pictures and Weather Maps) |
| Publication Title | 岡山大学教育実践総合センター紀要 |
| Published Date | 2009-03-10 |
| Volume | volume9 |
| Issue | issue1 |
| Start Page | 83 |
| End Page | 96 |
| ISSN | 1346-3705 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307462 |
| JaLCDOI | 10.18926/15106 |
|---|---|
| Title Alternative | Teacher education aimed at developing Practical teaching skills : The case of Okayama University Faculty of Education |
| FullText URL | 009_073_082.pdf |
| Author | Ariyoshi, Hideki| |
| Abstract | 近年の社会状況の急激な変化は,教員養成教育のカリキュラムについても大きな変革を求めている｡特に,学校現場が求めているのは,学校が担っている今日的な教育課題を遂行していく実践的な指導力を備えた教員の養成である｡教育職員養成審議会がこれまでの答申の中で提示してきた,教員の養成段階において身につけさせるべき教員の資質能力について参考にし,今日的な教育課題も視野に入れながら,岡山大学教育学部が実践的指導力を育成するため取り組んできた,教育実習の在り方,教員養成カリキュラムの理念と再構築等について考察する｡さらに,中央教育審議会が2006年に提示した｢教職実践演習｣の特徴を検討すると共に,この科目が必修化されることから,本学部では,この科目を4カ年の教員養成カリキュラムの中に,どのように位置づけて,実践的な指導力のいっそうの向上を目指しているか等についても考察していく｡ |
| Keywords | 実践的指導力 (practical teaching skills) 教育実習 (teaching practice) 教員養成教育 (teacher education) 資質能力 (traits and abilities) 教職実践演習 (Senior Seminar for Prospective Teachers) |
| Publication Title | 岡山大学教育実践総合センター紀要 |
| Published Date | 2009-03-10 |
| Volume | volume9 |
| Issue | issue1 |
| Start Page | 73 |
| End Page | 82 |
| ISSN | 1346-3705 |
| language | Japanese |
| File Version | publisher |
| NAID | 40016592502 |
| JaLCDOI | 10.18926/15104 |
|---|---|
| Title Alternative | THE IMPROVEMENT OF SKILL BY SNOWBOADING CLASS OF THE UNIVERSITY GENERAL EDUCATION ATHLETICS |
| FullText URL | 009_057_062.pdf |
| Author | Yamaguchi, Tatsuo| Sugiyama, Kiyoshi| |
| Abstract | 本研究はスノーボード集中授業により初心者の滑走スキルがどの程度向上したかを検討したものである｡実技試験を実施した結果､以下の如くの結果が得られた｡即ち､転倒者の割合は女子班では55.6%､男子班では50.0%と約半数が転倒する状態であった｡男子班は全員､連続ターンが出来ていたが女子班 では出来ないかほとんど出来ない者が約4割であった｡平均ターン回数は男子班が9.8回,女子班が2.9回で女子班の値が小さかった(P<0.1)｡その理由については､男女の体力差や指導方法の違いなどが考えられる｡試技の平均所要時間は男子班が33.0秒で女子班が41.0秒であった｡経験者班を基準にする と男子班は12.6%,女子班は40.0%余分に時間を要している状態であった｡事前のスケートボード練習の有効性は確認できなかった｡理由としては､練習の回数と時間が少な過ぎたことと参加者数が少なかったことによると推察される｡ |
| Keywords | スノーボード (Snowboarding) 大学一般教育体育実技 (university general education athletics) 集中授業 (an intensive class) 実技試験 (a skill test) スキルの向上 (the improvement of the skill) |
| Publication Title | 岡山大学教育実践総合センター紀要 |
| Published Date | 2009-03-10 |
| Volume | volume9 |
| Issue | issue1 |
| Start Page | 57 |
| End Page | 62 |
| ISSN | 1346-3705 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307502 |
| JaLCDOI | 10.18926/15103 |
|---|---|
| Title Alternative | Provision of guidance to students wishing to become teachers (1) : Status of how the Teaching Profession Consultation Office is being used |
| FullText URL | 009_051_056.pdf |
| Author | Matsubara, Yasumichi| Yamawaki, Ken| |
| Abstract | 教職相談室は､開設6年目となるが､本年4月より松原と山脇が前任者である西崎の後を受けつぎ､教員志望の学生の指導に当たっている｡指導の中心は､論作文､個人面接､集団面接､集団討論､模擬授業､場面指導､ロールプレイングなどであるが､その他に進路の相談､ボランティアや講師希望の相談など､学生の不安なこと､挑戦したいことなどの相談に当たった｡来室学生の積極性に我々も刺激を受け､現場の教師として力を発揮できる人間性の向上を中心に考えて､指導､支援した｡その結果､来室者の増加と合格者の増加を達成することができた｡ |
| Keywords | 教員志望学生 (Students wishing to become teachers) 教職相談室 (Teaching Profession Consultation) 指導内容 (content of guidance) 指導効果 (effects of guidance) |
| Publication Title | 岡山大学教育実践総合センター紀要 |
| Published Date | 2009-03-10 |
| Volume | volume9 |
| Issue | issue1 |
| Start Page | 51 |
| End Page | 56 |
| ISSN | 1346-3705 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307420 |
| JaLCDOI | 10.18926/15102 |
|---|---|
| Title Alternative | DEVELOPING THE SOCIAL STUDIES LESSON PLAN OF A JUNIOR HIGH SCHOOL TO MAKE STUDENTS UNDERSTAND THE GLOBALIZATION |
| FullText URL | 009_041_050.pdf |
| Author | Matsumoto, Shinpei| Kuwabara, Toshinori| |
| Abstract | 本研究は,生徒にグローバル化が進んだ現代社会を捉えさせるための中学校社会科の授業構成の原理と方法を提案しようとするものである｡そのために,本研究においては,教材として外国人労働者問題を取り上げ,外国人の労働者が近年なぜ増加しているのかを探究させることを通して,グローバル化の実 態とその原因を把握させる｡教材開発においては,社会学者のサスキア･サッセン氏の論を手がかりに到達目標である概念的説明的知識を抽出し,グローバル化が進んだ世界に対する科学的認識を形成することを目指した｡ |
| Keywords | グローバル化 (globalization) 外国人労働者 (foreign workers) 科学的社会認識 (social recognition) 社会科教育 (social studies education) |
| Publication Title | 岡山大学教育実践総合センター紀要 |
| Published Date | 2009-03-10 |
| Volume | volume9 |
| Issue | issue1 |
| Start Page | 41 |
| End Page | 50 |
| ISSN | 1346-3705 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307853 |
| JaLCDOI | 10.18926/15101 |
|---|---|
| Title Alternative | Promoting social interactions between students with autism and their teachers in various problem solving situations in play - and drama - unit lessons |
| FullText URL | 009_019_030.pdf |
| Author | Onoro, Hiroshi| |
| Abstract | 本研究では,自閉症の児童の学習集団を対象とした授業を通じて,課題意識の変化の様子や人とかかわる力の変化の様子を明示し,変化の背景にある教師の工夫を明らかにすることを目的とした｡対象とした三つの授業では,題材選定や活動展開及び教師のかかわりなどの点において,授業者自身の評価に基づく改善を施していった｡結果では,活動の在り方によって,課題意識をもった主体的な姿に変わっていく様子や,逆に児童の活動が制限される様子,また,児童が明確な課題意識を維持･深化させながら,人とのかかわりもより積極的にしていく様子などが示された｡このような児童の行動の変化から,授業改善において,課題が明確になりやすい題材選択,さらに教師のかかわりにおける課題の修正や焦点化などが,課題解決や人とかかわる力の育成を可能にすることが示唆された｡ |
| Keywords | 人とのかかわり (soacial interaction) 自閉症 (autism) 授業 (lesson) 課題意識 (task engagement) 相談タイム (group problem solving) |
| Publication Title | 岡山大学教育実践総合センター紀要 |
| Published Date | 2009-03-10 |
| Volume | volume9 |
| Issue | issue1 |
| Start Page | 19 |
| End Page | 30 |
| ISSN | 1346-3705 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307120 |
| JaLCDOI | 10.18926/15098 |
|---|---|
| Title Alternative | Influence on Stress Reactions of Social Skill and Cognitive Appraisal in Junior High Students |
| FullText URL | 009_001_008.pdf |
| Author | Nishimura, Hiroki| Tojo, Mitsuhiko| |
| Abstract | 本研究の目的は､中学生を対象に､社会的スキルとストレッサーに対する認知的評価､ストレス反応の関係性を明らかにし､社会的スキルが､認知的評価のストレス反応への影響を調整する効果(調整効果)について検討することであった｡その結果､ストレス反応に対する社会的スキルと認知的評価の影響には男女差が認められ､男子ではストレス反応と｢関係参加行動｣・「関係維持行動｣という基礎的なスキルの間に負の関連が認められた｡一方女子では､それら2つの基礎的なスキルに加え､認知的評価の｢コントロール可能性｣とストレス反応の間にも負の関連が､｢関係向上行動｣とストレス反応との問には正の関連が認められた｡調整効果については､女子において部分的に確認された｡ |
| Keywords | junior high school students social skills cognitive appraisal stress responses |
| Publication Title | 岡山大学教育実践総合センター紀要 |
| Published Date | 2009-03-10 |
| Volume | volume9 |
| Issue | issue1 |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 1346-3705 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307399 |
| JaLCDOI | 10.18926/15096 |
|---|---|
| Title Alternative | 気管支喘息に対する複合温泉療法の作用機序 3.気道炎症反応との関連 |
| FullText URL | 067_099_106.pdf |
| Author | Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | The degree and characteristic of airway inflammation were evaluated by the proportions of bronchoalveolar lavage (BAL) cells. Clinical asthma types such as Ia. simple bronchoconstriction, Ib. bronchoconstriction + hypersecretion, and Ⅱ. bronchiolar obstruction correlate with airway inflammation. The increased proportion BAL neutrophils is characteristic of type Ⅱ asthma, and increase in BAL eosinophil count is often observed in type Ib asthma. Bronchial hyperresponsiveness also correlates with airway inflammation. Action of spa therapy has been speculated to be related to airway inflammation, since the therapy has no action inhibiting IgE-mediated allergic reaction. In fact, spa therapy is more effective in patients with type Ib and type Ⅱ than in those with type Ia showing slight degree of airway inflammation. Bronchial hyperresponsiveness is also improved by spa therapy. From a point of view, the direct action of spa therapy may be to clean airways and improve damaged mucous membrane of the airways, leading to suppression of airway inflammation. |
| Keywords | Spa therapy (温泉療法) Airway inflammation (気道炎症反応) BAL eosinophilia (BAL好酸球増多) BAL neutrophilia (BAL好中球増多) Bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 99 |
| End Page | 106 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307894 |
| JaLCDOI | 10.18926/15095 |
|---|---|
| Title Alternative | Mechanisms of pancreatic fibrosis |
| FullText URL | 067_115_120.pdf |
| Author | Ochi, Koji| Chowdhury, Riaz| Ichimura, Mitsuko| Matsumura, Naoki| Tanaka, Juntaro| Mizushima, Takaaki| Yamamoto, Ryoichi| Harada, Hideo| Yokota, Satoshi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tanizaki, Yoshiro| |
| Abstract | 膵の線維化は慢性膵炎に特徴的な病理組織所見の一つであるが,その発生機序については不明な点か多い｡慢性膵炎はいったん発症すれば,進行性かつ非可逆性であるとされるが,その非可逆性に膵の線維化が関与するとされる｡膵の線維化の発生機序を明らかにし,線維化に対する根本的な治療法の確立が望まれるところである｡そこで,本稿では今後の膵の線維化の研究課題を明らかにする目的で,現在までの膵臓線維化の発生機序に関する知見を整理した｡ |
| Keywords | 膵臓 (pancreas) 線維化 (fibrosis) サイトカイン (cytokine) 慢性膵炎 (chronic pancreatitis) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 115 |
| End Page | 120 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307876 |
| JaLCDOI | 10.18926/15094 |
|---|---|
| Title Alternative | 気管支喘息に対する複合温泉療法の作用機序 2.内分泌･自律神経系および心因的要素に対する効果 |
| FullText URL | 067_092_098.pdf |
| Author | Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Saito, Katsuyoshi| |
| Abstract | Actions of spa therapy on endocrine-autonomic nerve system and psychological factors were analyzed in patients with bronchial asthma. In endocrine function, serum levels of cortisol and ACTH tended to increase after spa therapy. In autonomic nerve system, decrease in concentrations of serum adrenalin and noradrenalin was observed after spa therapy, and the difference between the initial levels before spa therapy and the levels after the therapy was significant in serum levels of adrenalin. However, serum levels of substance P and Bradykinin were not affected by spa therapy. To evaluate the action of spa therapy on mental condition in patients with asthma, four kinds of psychological tests, CMI, SDS, CAl and SD, were carried out. Improvement of mental disorders in patients with asthma is observed after spa therapy in all psychological tests. These results suggest that spa therapy acts effectively on endocrine-autonomic nerve system and improve psychological conditions. |
| Keywords | Bronchial asthma (気管支喘息) Spa therapy (温泉療法) Endocrine-autonomic nerve system (内分泌・自律神経系) Psychological disorders (心的要素) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 92 |
| End Page | 98 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307879 |
| JaLCDOI | 10.18926/15093 |
|---|---|
| Title Alternative | 気管支喘息に対する複合温泉療法の作用機序 1.温泉療法の評価方法との関連 |
| FullText URL | 067_085_091.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Action mechanisms of complex spa therapy (swimming training in a hot spring pool, inhalation with iodine salt solution, and fango therapy) were studied in relation to patient age, clinical asthma type, and airway inflammation. Actions of spa therapy were observed by two clinical effects : direct and indirect effects. Improvement of subjective symptoms, ventilatory function, and bronchial hyperresponsiveness was observed as direct effects of spa therapy, and improvement of suppressed function of adrenocortical glands as indirect effects of the therapy. The clinical effects of spa therapy were higher in patients over the age of 40. Regarding clinical asthma type, the effects were larger in patients with type Ib and type II asthma than in those with type Ia. The efficacy of spa therapy was closely related with airway inflammation in patients with type Ib and type II asthma. |
| Keywords | complex spa therapy (複合温泉療法) clinical asthma type (臨床病型) ventilatory function (換気機能) bronchial hyperresponsiveness (気道過敏性) adrenocortical glands (副腎皮質) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1996-11 |
| Volume | volume67 |
| Start Page | 85 |
| End Page | 91 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307192 |
