result 15372 件
| JaLCDOI | 10.18926/AMO/56071 |
|---|---|
| FullText URL | 72_3_257.pdf |
| Author | Asano, Keiichi| Edamatsu, Midori| F. Hatipoglu, Omer| Inagaki, Junko| Ono, Mitsuaki| Ohtsuki, Takashi| Oohashi, Toshitaka| Hirohata, Satoshi| |
| Abstract | Several research groups demonstrated that ‘a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs (ADAMTS)’-family proteases play roles in cancer progression. However, the origins and contributions of these proteases are not known. Here, we demonstrate an association between host-produced ADAMTS4 and early-stage tumor growth. Murine Lewis lung carcinoma (LLC) tumors showed marked expressions of Adamts4 and Adamts5. We examined the contributions and distributions of host-derived Adamts4 and Adamts5 on tumor growth, using Adamts4LacZ/LacZ and Adamts5LacZ/LacZ knockout mice. Interestingly, the Adamts4LacZ/LacZ mice showed enhanced tumor growth compared to wild-type mice at 5-, 10- and 12-days post-inoculation, whereas the Adamts5LacZ/LacZ mice did not show significant differences in tumor growth. We next examined LacZ distribution in LLC tumor-bearing Adamts4LacZ/LacZ mice by β-galactosidase (β-gal) staining. We found that the β-gal-positive signals were strictly localized at the interior areas of the tumor at 10 days post-inoculation. Multiple staining demonstrated that most of the β-gal-positive cells were localized at the tumor vasculature in Adamts4LacZ/LacZ mice. Interestingly, β-gal-positive signals were not co-localized with biglycan after 10 days post-inoculation, excluding the biglycan cleavage by host-derived ADAMTS4. Taken together, these findings illustrate that host-derived ADAMTS4 was expressed at the tumor vessels and was associated with early-stage tumor growth. |
| Keywords | ADAMTS metalloproteinase extracellular matrix tumor microenvironment mouse |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-06 |
| Volume | volume72 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 257 |
| End Page | 266 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29926003 |
| JaLCDOI | 10.18926/AMO/56070 |
|---|---|
| FullText URL | 72_3_249.pdf |
| Author | Nakahara, Takako| Suemori, Shin-ichiro| Tsujioka, Takayuki| Kataoka, Mikio| Kataoka, Hiromi| Shibakura, Misako| Tohyama, Kaoru| |
| Abstract | To investigate megakaryocyte (MK) DNA ploidy in various hematological diseases, fluorescence microscopy imaging system (FMI) can be used to analyze DNA ploidy with cell morphology at the single-cell level by using specialized image-processing software. Here we compared DNA ploidy obtained by FMI measured with that obtained flow cytometry (FCM). With FMI, we could evaluate the DNA ploidy in long-term preserved bone marrow smear samples after staining. We next analyzed the MK DNA ploidy in 42 bone marrow smear samples including 26 myeloid neoplasm cases, and we compared the DNA ploidy and platelet counts in the patients' peripheral blood; the production of platelets was significantly high compared to DNA ploidy in the myeloproliferative neoplasms group. The FMI method revealed that the patients with 5q- syndrome exhibited relatively low DNA ploidy despite high platelet counts, and this result suggested that increased DNA ploidy is not indispensable to abundant platelet production. The FMI method for DNA ploidy will be a useful tool to clarify the relationship between DNA ploidy and platelet production by MKs. |
| Keywords | fluorescence microscopy image analysis DNA ploidy megakaryocytes MDS with isolated del(5q) 5q- syndrome |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-06 |
| Volume | volume72 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 249 |
| End Page | 256 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29926002 |
| JaLCDOI | 10.18926/AMO/56069 |
|---|---|
| FullText URL | 72_3_241.pdf |
| Author | Kambara, Taiki| Tanimoto, Ryuta| Araki, Motoo| Saika, Takashi| Hashimoto, Hideaki| Oeda, Tadashi| Tsushima, Tomoyasu| Hayata, Shunji| Nasu, Yasutomo| Kobayashi, Yasuyuki| |
| Abstract | We retrospectively analyzed the factors related to postoperative cardiovascular (CV) events in patients undergoing partial nephrectomy (PN) or radical nephrectomy (RN) for clinical T1 renal cell carcinoma (RCC). We identified 570 patients who underwent PN or RN for T1 renal cell carcinoma between January 1998 and December 2009 at our institution and related hospitals. We determined the cumulative incidence rate of CV events and overall survival (OS) using Kaplan-Meier survival curves with a log-rank test, and we evaluated the risk for an increase in CV events and OS using Cox proportional hazard regression. Of the 570 patients, 171 underwent PN and 399 underwent RN. The type of surgery was not significantly related with CV events. The only factor that significantly increased the risk of CV events in both the univariate (HR 2.67, p=0.006) and multivariate analyses (HR 2.14, p=0.044) was a postoperative estimated glomerular filtration rate (eGFR) <45 ml/min/1.73 m2. Postoperative eGFR was also a significant risk factor for OS in the univariate analysis (HR 2.38, p=0.0104), but not in the multivariate model. Postoperative renal function was a significant independent predictor of the incidence of subsequent CV events. |
| Keywords | renal cell carcinoma nephrectomy partial nephrectomy renal function |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-06 |
| Volume | volume72 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 241 |
| End Page | 247 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29926001 |
| JaLCDOI | 10.18926/AMO/56068 |
|---|---|
| FullText URL | 72_3_231.pdf |
| Author | Darwinata, Agus Eka| Gotoh, Kazuyoshi| Mima, Takehiko| Yamamoto, Yumiko| Yokota, Kenji| Matsushita, Osamu| |
| Abstract | The bacterium Vibrio alginolyticus, an opportunistic pathogen in humans, has a type III secretion system (T3SS) that is responsible for its cytotoxicity toward eukaryotic cells. The effector of T3SS that is responsible for the cytotoxicity had not been identified. Here we demonstrate that VepA, a homolog of the T3SS effector in V. parahaemolyticus, is required for cytotoxicity in V. alginolyticus. VepA induces lysosomal membrane permeabilization, and it allows the leakage of only small molecules into the cytosol. Our findings revealed that VepA induces cathepsin-independent cell death in mammalian cells. The ferrous ion, one of the small molecules in the lysosome contents, appears to be involved in the cell death caused by V. alginolyticus VepA. |
| Keywords | cell death lysosomal membrane permeability VepA Vibrio alginolyticus |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-06 |
| Volume | volume72 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 231 |
| End Page | 239 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29926000 |
| JaLCDOI | 10.18926/AMO/56067 |
|---|---|
| FullText URL | 72_3_223.pdf |
| Author | Ida, Jun| Kotani, Kazuhiko| Miyoshi, Toru| Nakamura, Kazufumi| Kohno, Kunihisa| Asonuma, Hirohiko| Sakuragi, Satoru| Doi, Masayuki| Miki, Takashi| Koyama, Yasushi| Ito, Hiroshi| |
| Abstract | Lipoprotein(a), or Lp(a), is a low-density lipoprotein-like particle largely independent of known risk factors for, and predictive of, cardiovascular disease (CVD). We investigated the association between baseline Lp(a) levels and the progression of coronary artery calcification (CAC) in patients with hypercholesterolemia undergoing statin therapy. This study was a sub-analysis of a multicenter prospective study that evaluated the annual progression of CAC under intensive and standard pitavastatin treatment with or without eicosapentaenoic acid in patients with an Agatston score of 1 to 999, and hypercholesterolemia treated with statins. We classified the patients into 3 groups according to CAC progression. A total of 147 patients (mean age, 67 years; men, 54%) were analyzed. The proportion of patients with Lp(a) > 30 mg/dL significantly increased as CAC progressed (non-progression; 5.4%, 0 |
| Keywords | lipoprotein(a) coronary artery calcification statins hypercholesterolemia |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-06 |
| Volume | volume72 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 223 |
| End Page | 230 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29925999 |
| JaLCDOI | 10.18926/AMO/56066 |
|---|---|
| FullText URL | 72_3_211.pdf |
| Author | Ikeda, Chikako| Yokota, Osamu| Miki, Tomoko| Takenoshita, Shintaro| Ishizu, Hideki| Terada, Seishi| Yamada, Norihito| |
| Abstract | Neurodegenerative diseases in which tau accumulation plays a cardinal role in the pathogenic process are called tauopathies, and when tau isoforms having four repeats of the microtubule binding sites, four-repeat tau, are selectively accumulated as pathological hallmarks, the term four-repeat tauopathy is used. The major four-repeat tauopathies are progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and argyrophilic grain disease (AGD). Historically, neuronal cytopathologies, e.g., neurofibrillary tangles and ballooned neurons, were emphasized as characteristic lesions in PSP and CBD. Now, however, astrocytic tau pathologies, i.e., tufted astrocytes (TAs) and astrocytic plaques (APs), are considered to be highly disease-specific lesions. Although granular/fuzzy astrocytes (GFAs) frequently develop in the limbic system in AGD cases, the specificity is not conclusive yet. Some AGD cases have a few TAs, and to a lesser frequency, a few APs in the frontal cortex and subcortical nuclei. The number of astrocytic tau pathologies including TAs and GFAs increases with the progression of AGD. In this paper, histopathological features of astrocytic tau pathologies in PSP, CBD, and AGD are first reviewed. Then, recent findings regarding the coexistence of these tauopathies are summarized from a viewpoint of astrocytic tau pathologies. Further biochemical and pathological studies focusing tau-positive astrocytic lesions may be useful to increase understanding of the pathological process in four-repeat tauopathies and to develop novel therapeutic strategies for patients with these diseases. |
| Keywords | astrocytic plaque four-repeat tau globular glial inclusion granular fuzzy astrocyte tufted astrocyte |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-06 |
| Volume | volume72 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 211 |
| End Page | 221 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29925998 |
| FullText URL | 130_47.pdf |
|---|---|
| Author | Okayama Medical Association| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 47 |
| End Page | 49 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| Title Alternative | The 66th Medical Education Development Center, Seminar and Workshop in Okayama University |
|---|---|
| FullText URL | 130_45.pdf |
| Author | Nasu, Yasutomo| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 43 |
| End Page | 44 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.45 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.45 |
| NAID | 130006730883 |
| Title Alternative | The 7th Annual Meeting of Japan Society for Dementia Prevention |
|---|---|
| FullText URL | 130_43.pdf |
| Author | Abe, Koji| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 43 |
| End Page | 44 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.43 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.43 |
| NAID | 130006730882 |
| FullText URL | 130_41.pdf |
|---|---|
| Author | 来住 由樹| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 41 |
| End Page | 42 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| Title Alternative | Migraine treatment using transcatheter closure of a patent foramen ovale |
|---|---|
| FullText URL | 130_37.pdf |
| Author | Akagi, Teiji| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 37 |
| End Page | 39 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.37 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.37 |
| NAID | 130006730885 |
| Title Alternative | Drug interaction (41. Drug interaction in chronic myeloid leukemia therapy) |
|---|---|
| FullText URL | 130_33.pdf |
| Author | Nakamoto, Akihiko| Kajizono, Makoto| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 33 |
| End Page | 36 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.33 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.33 |
| NAID | 130006730884 |
| Title Alternative | Q22 ; Q23 |
|---|---|
| FullText URL | 130_31.pdf |
| Author | Okayama Medical Association| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 31 |
| End Page | 32 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.31 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.31 |
| NAID | 130006730879 |
| Title Alternative | New System of Japanese Medical Specialty : Internal Medicine |
|---|---|
| FullText URL | 130_25.pdf |
| Author | Obika, Mikako| Otsuka, Fumio| Okada, Hiroyuki| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 25 |
| End Page | 30 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.25 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.25 |
| NAID | 130006730864 |
| Title Alternative | Metaplastic carcinoma of the breast : Two cases |
|---|---|
| FullText URL | 130_19.pdf |
| Author | Motoki, Takayuki| Iwamoto, Takayuki| Omori, Masako| Matsuoka, Junji| |
| Abstract | We treated two patients with a rare metaplastic carcinoma of the breast. Patient 1：A 32-year-old woman presented with a rapidly growing mass（ 7cm） in her right breast. We diagnosed cT3N0M0 Stage IIB breast cancer and performed a radical resection. The pathological diagnosis was triple-negative metaplastic carcinoma with a Ki-67 value ＞30%. Postoperative adjuvant chemotherapy and radiotherapy were performed. Patient 2：A 66-year-old postmenopausal woman presented with a left breast mass. We diagnosed cT1N0M0 Stage I breast cancer and performed a radical resection. The pathological diagnosis was triple-negative metaplastic carcinoma with a Ki-67 value ＞30%. Postoperative adjuvant chemotherapy was performed. Patients 1 and 2 have achieved relapse-free survivals of 1 year＋2 months and 10 months, respectively. Metaplastic carcinoma of the breast is a rare tumor, and its prognosis is not favorable. The only available treatment is that used for invasive ductal carcinoma；a more specific treatment has not been established. The accumulation of further similar cases and the development of a novel effective treatment are desired. |
| Keywords | 乳癌（breast cancer） 化生癌（metaplastic carcinoma） 化学療法（chemotherapy） |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 19 |
| End Page | 23 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.13 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.13 |
| NAID | 130006730866 |
| Title Alternative | A case of a mesenteric desmoid tumor preoperatively distinguished from imaging findings |
|---|---|
| FullText URL | 130_13.pdf |
| Author | Kawai, Takashi| Watanabe, Takanori| Nobuhisa, Tetuji| Matumoto, Yusuke| Kai, Kyohei| Sato, Shiso| |
| Abstract | A 73-year-old woman was admitted for closer investigation into an abdominal tumor. Abdominal ultra-sonography, CT, and magnetic resonance imaging showed a discrete abdominal tumor. Especially on MRI, the tumor appeared as a relatively ill-defined whorled soft-tissue thickening within the mesenteric fat, causing angulation or speculation of adjacent bowel mesentery. Surgery was performed under a presumptive diagnosis of a mesojejunum desmoid. The tumor was invading the transverse mesocolon and mesojejunum as well as the third portion of the duodenum and the middle colic artery, and it was close to but apart from the superior mesenteric artery. The tumor was resected, including removal of part of the duodenum and transverse colon. The specimen contained a white solid tumor measuring 14×12×8cm. Pathologic examination showed differentiated fibroblasts and copious collagen fibers. The tumor was negative for CD34, c-kit, S-100, and α-SMA, but positive for β-catenin. On the basis of these findings, we established a diagnosis of mesenteric desmoid tumor of the small intestine. The patient has been followed postoperatively for 2 years, no sign of recurrence, to date. |
| Keywords | 小腸間膜 (mesentery of the small intestine) デスモイド (desomoid) 腸間膜腫瘍 (mesenteric tumor) |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 13 |
| End Page | 18 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.13 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.13 |
| NAID | 130006730865 |
| Title Alternative | Adjuvant chemotherapy for non small-cell lung cancer |
|---|---|
| FullText URL | 130_9.pdf |
| Author | Toyooka, Shinichi| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 9 |
| End Page | 12 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.9 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.9 |
| NAID | 130006730889 |
| Title Alternative | The 2016 Incentive Award of the Okayama Medical Association in Neuroscience (2016 Niimi Prize) |
|---|---|
| FullText URL | 130_5.pdf |
| Author | Sasaki, Tatsuya| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 5 |
| End Page | 7 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.5 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.5 |
| NAID | 130006730888 |
| Title Alternative | The 2016 Incentive Award of the Okayama Medical Association in General Medical Science (2016 Yuuki Prize) |
|---|---|
| FullText URL | 130_1.pdf |
| Author | Okamoto, Sachiyo| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-04-02 |
| Volume | volume130 |
| Issue | issue1 |
| Start Page | 1 |
| End Page | 3 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.1 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.1 |
| NAID | 130006730867 |
| FullText URL | Biochem_Biophy_Res_Comm_201807.pdf |
|---|---|
| Author | Fujiwara, Toshifumi| Eguchi, Takanori| Sogawa, Chiharu| Ono, Kisho| Murakami, Jun| Ibaragi, Soichiro| Asaumi, Jun-ichi| Okamoto, Kuniaki| Calderwood, Stuart K.| Kozaki, Ken-ichi| |
| Keywords | Extracellular vesicles Anti-EGFR antibody therapy Cetuximab Epithelial-to-mesenchymal transition Head and neck squamous cell carcinoma |
| Published Date | 2018-07-13 |
| Publication Title | Biochemical and Biophysical Research Communications A |
| Publisher | Elsevier |
| ISSN | 0006291X |
| NCID | AA00564395 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| File Version | publisher |
| DOI | 10.1016/j.bbrc.2018.07.035 |
| Related Url | isVersionOf https://doi.org/10.1016/j.bbrc.2018.07.035 |
